keyword
https://read.qxmd.com/read/38509432/treatment-of-multisystem-inflammatory-syndrome-in-children
#1
REVIEW
Tong Tong, Yi-Hua Jin, Min Wang, Fang-Qi Gong
BACKGROUND: Multisystem inflammatory syndrome in children (MIS-C), a relatively uncommon but severe pediatric complication, is associated with coronavirus disease 2019 (COVID-19). A variety of treatment approaches, including intravenous immunoglobulins (IVIGs), glucocorticoids (GCs) and biologic agents, such as anakinra and infliximab, have been described for the management of COVID-19-related MIS-C. Anticoagulant therapy is also important. However, a well-developed treatment system has not been established, and many issues remain controversial...
March 21, 2024: World Journal of Pediatrics: WJP
https://read.qxmd.com/read/38508571/different-dose-aspirin-plus-immunoglobulin-dapi-for-prevention-of-coronary-artery-abnormalities-in-kawasaki-disease-study-protocol-for-a-multi-centre-prospective-randomized-open-label-blinded-end-point-non-inferiority-trial
#2
JOURNAL ARTICLE
Yujian Wu, Lin Hu, Xiaofei Xie, Wei Li, Yanfei Wang, Li Zhang, Ping Huang, Fengxiang Li, Jianbin Li, Shuliang Xia, Jia Yuan, Ming Li, Zhouping Wang, Xu Zhang
BACKGROUND: Kawasaki disease is a pediatric acute systemic vasculitis that specifically involves the coronary arteries. Timely initiation of immunoglobulin plus aspirin is necessary for diminishing the incidence of coronary artery abnormalities (CAAs). The optimal dose of aspirin, however, remains controversial. The trial aims to evaluate if low-dose aspirin is non-inferior to moderate-dose in reducing the risk of CAAs during the initial treatment of Kawasaki disease. METHODS: This is a multi-centre, prospective, randomized, open-label, blinded endpoint, non-inferiority trial to be conducted in China...
March 18, 2024: American Heart Journal
https://read.qxmd.com/read/38503318/drugs-and-natural-products-for-the-treatment-of-covid-19-during-2020-the-first-year-of-the-pandemic
#3
JOURNAL ARTICLE
Elia G Jaimes-Castelán, Claudia González-Espinosa, Gil A Magos-Guerrero, Isabel Arrieta-Cruz, Manuel Jiménez-Estrada, Ricardo Reyes-Chilpa, Jorge I Castillo-Arellano
This work aimed to show which treatments showed efficacy against coronavirus disease 2019 (COVID-19); therefore, the results of 37 clinical trials started in 2020 and completed in 2021 are reviewed and discussed here. These were selected from databases, excluding vaccines, computational studies, in silico, in vitro, and those with hyperimmune sera from recovered patients. We found 34 drugs, one vitamin, and one herbal remedy with pharmacological activity against symptomatic COVID-19. They reduced mortality, disease progression, or recovery time...
2024: Boletín Médico del Hospital Infantil de México
https://read.qxmd.com/read/38489091/aspirin-responsiveness-in-a-cohort-of-pediatric-patients-with-right-ventricle-to-pulmonary-artery-conduits-and-transcatheter-valve-replacement-systems
#4
JOURNAL ARTICLE
Sean T Kelleher, Irene E Regan, Dermot Cox, Kathryn Shaw, Orla Franklin, Damien P Kenny, Kevin P Walsh, Colin J McMahon
The aim of this study was to determine the rate of aspirin responsiveness in a cohort of pediatric patients with in situ xenograft valved right ventricle to pulmonary artery (RV-PA) conduits and/or transcatheter valve replacements (TVR). Aspirin is routinely prescribed to these patients. Optimizing anti-platelet therapy could promote valve longevity and reduce the risk of infective endocarditis in this at-risk group. This was a prospective, observational study. Patients were recruited from both ward and outpatient settings...
March 15, 2024: Pediatric Cardiology
https://read.qxmd.com/read/38488239/biologic-therapy-in-pediatric-chronic-rhinosinusitis-a-systematic-review
#5
REVIEW
Sara Rahavi-Ezabadi, Sheng Zhou, Stella E Lee, Elisabeth Ference, Anthony Magit, Shelby Leuin, Kawthar Mohamed, Nima Rezaei, Vijay A Patel
OBJECTIVE: Provide clinicians with current evidence for biologic therapy in children with chronic rhinosinusitis with nasal polyposis (CRSwNP). DATA SOURCES: PubMed, MEDLINE, Cochrane, and clinical trial registries. REVIEW METHODS: Key search terms related to biologic therapy in pediatric CRSwNP were identified via a structured query of current medical literature and clinical trial databases. CONCLUSIONS: There is a dearth of active clinical trials and research studies for biologics targeting pediatric CRSwNP...
March 15, 2024: Otolaryngology—Head and Neck Surgery
https://read.qxmd.com/read/38447120/delayed-rewarming-thrombocytopenia-drt-a-suggested-preventable-and-treatable-cause-of-rewarming-deaths
#6
JOURNAL ARTICLE
Ian J Cohen
The lack of a consensus of accepted prognostic factors in hypothermia suggests an additional factor has been overlooked. Delayed rewarming thrombocytopenia (DRT) is a novel candidate for such a role. At body temperature, platelets undergoing a first stage of aggregation are capable of progression to a second irreversible stage of aggregation. However, we have shown that the second stage of aggregation does not occur below 32°C and that this causes the first stage to become augmented (first-stage platelet hyperaggregation)...
March 7, 2024: Journal of Pediatric Hematology/oncology
https://read.qxmd.com/read/38245705/hemolytic-anemia-associated-with-intravenous-immunoglobulin-in-kawasaki-disease
#7
JOURNAL ARTICLE
Eun Jung Cheon, Jun Suk Oh
BACKGROUND: The administration of high-dose intravenous immunoglobulin (IVIG) is a standard treatment for the management of Kawasaki disease (KD). IVIG is known to be a highly effective and safe treatment. CASE PRESENTATION: We report the development of hemolytic anemia in seven children receiving repeated doses of IVIG. The children were aged 3-44 months and included 4 girls and 3 boys. All children received 10% IVIG and a second course of immunoglobulin because they did not respond to the first course of immunoglobulin...
January 20, 2024: BMC Pediatrics
https://read.qxmd.com/read/38240348/thromboembolism-prophylaxis-practices-of-pediatric-and-congenital-electrophysiologists-during-invasive-electrophysiology-studies-a-paces-survey
#8
JOURNAL ARTICLE
Suneet Bhansali, Michael Antonchak, Frank Cecchin, Reina Bianca Tan
BACKGROUND: Thromboembolic events related to invasive electrophysiology studies, while rare, can have devastating consequences. Use of systemic anticoagulation for a pediatric or adult-congenital invasive electrophysiology study is recommended, however there is no established standard of practice in this population. OBJECTIVE: To report on procedural practices for thromboembolism prophylaxis during invasive electrophysiology studies for pediatric patients and adults with congenital heart disease...
January 19, 2024: Pacing and Clinical Electrophysiology: PACE
https://read.qxmd.com/read/38215810/safety-of-same-day-discharge-without-anticoagulation-for-left-sided-radiofrequency-catheter-ablations-in-pediatrics
#9
JOURNAL ARTICLE
Vincent Palmieri, Yijin Xiang, Peter Fischbach, Robert Whitehill
BACKGROUND: For left-sided radiofrequency catheter ablation (LCAs) in pediatrics, significant practice variability exists regarding anticoagulation and discharge practices. Given the lack of data in pediatric patients, the risks and benefits of these practices are not well defined. OBJECTIVE: The purpose of this study was to evaluate the safety of same-day discharge and use of aspirin (ASA) in pediatric patients following LCAs. METHODS: We performed a retrospective cohort study of pediatric patients who underwent a LCA from 2010 to 2020 at our institution...
January 10, 2024: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://read.qxmd.com/read/38169229/multisystem-inflammatory-syndrome-in-children-during-the-covid-19-pandemic-a-review-of-clinical-manifestations-cardiac-complications-and-medical-management
#10
JOURNAL ARTICLE
Maya Pandit, William H Frishman
The SARS-CoV-2 pandemic has led to widespread research on associated clinical syndromes. While pediatric patients were initially deemed as a low-risk population for severe COVID-related disease, an increasing number of case reports have revealed a rare but potentially life-threatening syndrome, multisystem inflammatory syndrome in children (MIS-C). MIS-C is hypothesized to be due to hyperactivation of the immune system via a cytokine storm which leads to end-organ damage via endothelial dysfunction and changes in vascular permeability...
January 3, 2024: Cardiology in Review
https://read.qxmd.com/read/38166957/a-rare-case-of-coronary-artery-complication-in-a-child-with-systemic-juvenile-idiopathic-arthritis-and-macrophage-activation-syndrome-case-report-and-literature-review
#11
REVIEW
Lian Zhang, Yanwen Wei, Ningjing Zeng, Lianyu Wang, Xinying Chen, Jinghua Yang, Xiaolan Xiao
A rare case of coronary artery involvement in a child with Systemic Juvenile Idiopathic Arthritis (sJIA) complicated by Macrophage Activation Syndrome (MAS) is reported. The patient initially received an inaccurate diagnosis of Kawasaki Disease, sepsis, and mycoplasma infection and showed no improvement after Intravenous Immune Globulin (IVIG) treatment. Upon admission, symptoms included diffuse red rash, swelling of the limbs, lymph node enlargement, and hepatosplenomegaly. Post investigations, a diagnosis of sJIA and MAS was confirmed, and treatment involved a combination of hormones (methylprednisolone) and immunosuppressive drugs (methotrexate)...
January 2, 2024: Pediatric Rheumatology Online Journal
https://read.qxmd.com/read/38153548/analysis-of-platelet-function-testing-in-children-receiving-aspirin-for-antiplatelet-effects
#12
JOURNAL ARTICLE
David M Newland, Michelle M Palmer, Lisa R Knorr, Jennifer L Pak, Erin L Albers, Joshua M Friedland-Little, Borah J Hong, Yuk M Law, Kathryn L Spencer, Mariska S Kemna
Aspirin (ASA) remains the most common antiplatelet agent used in children. VerifyNow Aspirin Test® (VN) assesses platelet response to ASA, with therapeutic effect defined by the manufacturer as ≤ 549 aspirin reaction units (ARU). Single-center, observational, analysis of 195 children (< 18 years-old) who underwent first VN between 2015 and 2020. Primary outcome was proportion of patients with ASA biochemical resistance (> 549 ARU). Secondary outcomes included incidence of new clinical thrombotic and bleeding events during ≤ 6 months from VN in those who received ASA monotherapy (n = 113)...
December 28, 2023: Pediatric Cardiology
https://read.qxmd.com/read/38083854/incomplete-kawasaki-disease-presenting-as-retropharyngeal-abscess-a-case-report-and-review-of-the-literature
#13
JOURNAL ARTICLE
Jun Chen, Yang Wen
Kawasaki disease (KD) is a cryptic and self-limiting vasculitis predominantly seen in children, often posing a diagnostic challenge due to its varied clinical presentations. Among these, the emergence of deep neck infections, particularly retropharyngeal abscesses, stands out as an extremely rare manifestation. Herein, we present a case of a 10-year-old girl who was hospitalized for fever, neck pain, swollen cervical lymph nodes, and increased inflammation markers. Although anti-infective treatment was initiated, her condition remained unchanged...
December 11, 2023: Ear, Nose, & Throat Journal
https://read.qxmd.com/read/38025153/novel-dosing-and-monitoring-of-aspirin-in-infants-with-systemic-to-pulmonary-artery-shunt-physiology-the-soprano-study
#14
JOURNAL ARTICLE
Joshua W Branstetter, Gary Woods, Hania Zaki, Nicole Coolidge, Tawanda Zinyandu, Subhadra Shashidharan, Alaa Aljiffry
OBJECTIVES: Provision of pulmonary blood flow with a systemic-to-pulmonary artery shunt is essential in some patients with cyanotic congenital heart disease. Traditionally, aspirin (ASA) has been used to prevent thrombosis. We evaluated ASA dosing with 2 separate antiplatelet monitoring tests for accuracy and reliability. METHODS: This is a retrospective, pre-post intervention single center study. Two cohorts were evaluated; the pre-intervention group used thromboelastography platelet mapping (TPM) and post-intervention used VerifyNow aspirin reactivity unit (ARU) monitoring...
2023: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://read.qxmd.com/read/37917176/association-between-aspirin-dose-and-outcomes-in-patients-with-acute-kawasaki-disease-a-nationwide-retrospective-cohort-study-in-japan
#15
JOURNAL ARTICLE
Takanori Suzuki, Nobuaki Michihata, Yohei Hashimoto, Tetsushi Yoshikawa, Kazuyoshi Saito, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga
UNLABELLED: This study aimed to identify the appropriate dose of aspirin to be prescribed to patients with acute Kawasaki disease (KD). Using a Japanese national inpatient database, we identified patients with KD treated with intravenous immunoglobulin between 2010 and 2021.The outcomes included the occurrence of coronary artery abnormalities and intravenous immunoglobulin resistance, length of hospital stay, and medical costs. Restricted cubic spline functions were performed to examine the association between aspirin dose and the outcomes...
November 2, 2023: European Journal of Pediatrics
https://read.qxmd.com/read/37903825/comparative-effectiveness-of-two-intravenous-immunoglobulin-products-in-children-with-kawasaki-disease-a-nationwide-cohort-study
#16
RANDOMIZED CONTROLLED TRIAL
Ni-Chun Kuo, Ching-Heng Lin, Ming-Chih Lin
Kawasaki Disease (KD) is the most common acquired pediatric heart disease in the developed world. Rapid infusion of high-dose intravenous immunoglobulin is the standard therapy. Different manufacturing processes of IVIG may influence their efficacy. This study aims to conduct a head to head comparison of two IVIGs, TBSF and Privigen, from a nationwide perspective. The main data source was the National Health Insurance Research Database (NHIRD) of Taiwan. A total of 3368 KD cases involving children under 2 years of age were enrolled from January 2015 to November 2020...
October 30, 2023: Scientific Reports
https://read.qxmd.com/read/37897455/experience-of-ivig-treatment-in-an-overweight-14-year-old-child-with-kawasaki-disease-a-case-report
#17
JOURNAL ARTICLE
Hui Shi, Jian-Li Qiu, Yan Xu, Lu-Lu Yang
Kawasaki disease, or mucocutaneous lymph node syndrome, is an acute systemic vasculitis involving small and medium-sized vessels. It can be complicated by varying degrees of cardiac damage, especially coronary artery disease. The disease mainly occurs in children aged < 5 years, with rarer cases in older children and adults. Intravenous immunoglobulin combined with aspirin is the widely accepted treatment regimen in the acute phase, but the dosage recommended by the American Heart Association guidelines is not suitable for heavier children...
October 25, 2023: Journal of Pediatric Health Care
https://read.qxmd.com/read/37862698/treatments-and-severe-outcomes-for-patients-diagnosed-with-mis-c-at-four-children-s-hospitals-in-the-united-states-march-16-2020-march-10-2021
#18
JOURNAL ARTICLE
Ami B Shah, Joseph Y Abrams, Shana Godfred-Cato, Amber Kunkel, Teresa A Hammett, Maria A Perez, Hui-Mien Hsiao, Nadine Baida, Christina A Rostad, Wassim Ballan, Kaleo Ede, Federico R Laham, Carol M Kao, Matthew E Oster, Ermias D Belay
BACKGROUND: Clinical management of multisystem inflammatory syndrome in children (MIS-C) has varied over time and by medical institution. METHODS: Data on patients with MIS-C were collected from 4 children's hospitals between March 16, 2020 and March 10, 2021. Relationships between MIS-C treatments and patient demographics, clinical characteristics, and outcomes were described. Propensity score matching was utilized to assess the relative risk of outcomes dependent on early treatment with intravenous immunoglobulin (IVIG) or low-dose steroids, controlling for potential confounding variables...
November 1, 2023: Pediatric Infectious Disease Journal
https://read.qxmd.com/read/37776659/monogenic-causes-of-cerebrovascular-disease-in-childhood-a-case-series
#19
REVIEW
Bridget E L Ostrem, Deena Godfrey, Paul A Caruso, Patricia L Musolino
BACKGROUND: Despite an increase in the number of genes associated with pediatric stroke, imaging phenotypes in children have not been well reported. Guidelines are needed to facilitate the identification and treatment of patients with monogenic causes of cerebrovascular disorders. METHODS: We performed a retrospective review of imaging and medical records of patients aged zero to 21 years with monogenic causes of vascular malformations, small or large vessel disease, transient ischemic attacks, and/or ischemic or hemorrhagic stroke...
December 2023: Pediatric Neurology
https://read.qxmd.com/read/37767178/unexpected-stormy-course-after-uneventful-device-closure-of-atrial-septal-defect-possibly-due-to-post-covid-19-inflammatory-state
#20
Anil Kumar Singhi, Soumya Kanti Mohapatra, Sanjeev S Mukherjee, Soumen Das, Tanumoy Maulick, Arnab De
COVID-19 infection has myriad manifestations from self-limiting illness to stormy multi-organ failure. A 28-year-old woman negative for COVID reverse transcription-polymerase chain reaction underwent an uneventful elective device closure of atrial septal defect on intubation anesthesia. While a brief postprocedural endotracheal bleed was noted, significant hypoxia and respiratory distress ensued after extubation with biventricular dysfunction, pleural effusion, and radiographic evidence of acute respiratory distress syndrome...
2023: Annals of Pediatric Cardiology
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