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https://www.readbyqxmd.com/read/29150885/recognizing-the-haystack-is-the-task-of-the-primary-care-physician
#1
N A Kukutsch, G Argenziano, W Bergman
In a reply to our letter Ferrandiz and colleagues wondered why dermoscopy experts did not already fully embrace teledermoscopy (TD) for suspicious pigmented skin lesions.(1) Our study showed that the structure of the health systems that were investigated differed, with countries where primary care physicians (PCP) hold a gate keeper function and others with direct access to a dermatologist. Significant differences in waiting time and travel distance were observed.(2) Since we believe that there is enough evidence that the addition of high quality dermoscopic pictures to a teleconsultation leads to higher accuracy of the diagnosis we did not investigate this question in our survey...
November 17, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29145030/the-use-of-econsults-to-improve-access-to-specialty-care-in-thrombosis-medicine
#2
Leslie Skeith, Medina Mohamed, Alan Karovitch, Clare Liddy, Amir Afkham, Douglas Archibald, Erin Keely
INTRODUCTION: Electronic consultations (eConsults) are asynchronous, consultative electronic-based communications that are aimed to improve efficient and timely access to specialist advice. Our study aim was to evaluate the use and impact of the Canadian Champlain BASE™ (Building Access to Specialists through eConsultation) eConsult service in the specialty of thrombosis medicine. METHODS: We conducted a cross-sectional study that included descriptive statistics of provider and patient demographic information and consultative-specific data...
November 7, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/29145004/effects-of-primary-care-physician-density-urologist-presence-and-insurance-status-on-stage-of-diagnosis-for-urologic-malignancies
#3
Kristy D Nguyen, Zain Z Hyder, Marshall D Shaw, Sarah B Maness, Michael S Cookson, Sanjay G Patel, Kelly L Stratton
OBJECTIVE: To evaluate effects of PCP density, insurance status, and urologist presence on stage of diagnosis for urologic malignancies. Cancer stage at diagnosis is an important outcome predictor. Studies have shown an inverse relationship to primary care physician (PCP) density and insurance coverage with stage of cancer diagnosis. METHODS: Data was obtained from OK2Share, an Oklahoma Central Cancer Registry, for bladder, kidney, and prostate cancer from 2000 to 2010...
November 13, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/29138020/moyamoya-syndrome-in-a-pediatric-patient-with-congenital-human-immunodeficiency-virus-type-1-infection-resulting-in-intracranial-hemorrhage
#4
Junko Yamanaka, Ikuma Nozaki, Mizue Tanaka, Hideko Uryuu, Noriko Sato, Takeji Matsushita, Hiroyuki Shichino
In the era of Antiretroviral Therapy (ART) in which human immunodeficiency virus type 1 (HIV-1) infection affected children can expect a better prognosis, the importance of careful follow up of pediatric HIV-1 cases for neurological complications has been growing. We present a case of hemorrhagic Moyamoya syndrome in a child with congenital HIV-1 infection. A 10-year-old girl was referred to our hospital for the treatment of Pneumocystis Jirovecii Pneumonia (PCP: Pneumocystis pneumonia). Her HIV-1 control was poor and Moyamoya syndrome was found during the opportunistic infection screening at admission...
November 11, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29135400/-the-comparison-of-microscopy-and-real-time-polymerase-chain-reaction-methods-for-the-diagnosis-of-pneumocystis-jirovecii-pneumonia-evaluation-of-clinical-parameters
#5
Seray Töz, Cumhur Gündüz, Aslı Tetik, Meltem Taşbakan, Hüsnü Pullukçu, Feza Bacakoğlu, Mehmet Sezai Taşbakan, Figen Gülen, Ayşegül Ünver, Nevin Turgay
Introduction: Pneumocystis jirovecii pneumonia (PCP) causes serious infections, especially in patients with immunosuppressive diseases. In this study, it was aimed to evaluate the results of samples obtained from PCP suspected patients using two different methods together with clinical data. Materials and Methods: Microscopy and real time polymerase chain reaction (real time PCR) methods were performed with bronchoalveolar lavage (BAL) samples sended to Ege University Medical Faculty Direct Parasitology Diagnostic Laboratory between March 2009 and June 2010...
September 2017: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/29131950/cooperative-bond-scission-in-a-soft-porous-crystal-enables-discriminatory-gate-opening-for-ethylene-over-ethane
#6
Susan Sen, Nobuhiko Hosono, Jia-Jia Zheng, Shinpei Kusaka, Ryotaro Matsuda, Shigeyoshi Sakaki, Susumu Kitagawa
Here we report a soft porous crystal possessing hemilabile crosslinks in its framework that exhibits exclusive gate opening for ethylene, enabling the discriminatory adsorption of ethylene over ethane. A Co-based porous coordination polymer (PCP) bearing vinylogous tetrathiafulvalene (VTTF) ligands, [Co(VTTF)], forms Co-S bonds as intermolecular crosslinks in its framework in the evacuated closed state. The PCP recognizes ethylene via d-π complexation on the accessible metal site that displaces and cleaves the Co-S bond to "unlock" the closed structure...
November 13, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29131897/comparison-of-hospital-resource-use-and-outcomes-among-hospitalists-primary-care-physicians-and-other-generalists
#7
Jennifer P Stevens, David J Nyweide, Sha Maresh, Laura A Hatfield, Michael D Howell, Bruce E Landon
Importance: A physician's prior experience caring for a patient may be associated with patient outcomes and care patterns during and after hospitalization. Objective: To examine differences in the use of health care resources and outcomes among hospitalized patients cared for by hospitalists, their own primary care physicians (PCPs), or other generalists. Design, Setting, and participants: This retrospective study analyzed admissions for the 20 most common medical diagnoses among elderly fee-for-service Medicare patients from January 1 through December 31, 2013...
November 13, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29128144/the-antipsychotic-drug-brexpiprazole-reverses-phencyclidine-induced-disruptions-of-thalamocortical-networks
#8
Hanna E van den Munkhof, Jørn Arnt, Pau Celada, Francesc Artigas
Brexpiprazole (BREX), a recently approved antipsychotic drug in the US and Canada, improves cognitive dysfunction in animal models, by still largely unknown mechanisms. BREX is a partial agonist at 5-HT1A and D2 receptors and antagonist at α1B- and α2C-adrenergic and 5-HT2A receptors all with a similar potency. The NMDA receptor antagonist phencyclidine (PCP), used as pharmacological model of schizophrenia, activates thalamocortical networks and decreases low frequency oscillations (LFO; <4 Hz). These effects are reversed by antipsychotics...
November 8, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29127932/the-effects-of-different-types-of-crop-straw-on-the-transformation-of-pentachlorophenol-in-flooded-paddy-soil
#9
Jiajiang Lin, Jun Meng, Yan He, Jianming Xu, Zuliang Chen, Philip C Brookes
The incorporation of various types of crop straw to agricultural soils has long been practiced to improve soil fertility. However, the effects of crop straw on the fate of organo-chlorine pesticides in flooded paddy soils are not well understood. The dechlorination of pentachlorophenol (PCP) in four vertical profiles (0-10, 10-20, 20-30, 30-50 mm depth) of two flooded paddy soils, a Plinthudult (Soil 1) and a Tropudult (Soil 2) was investigated following the application of four crop straws (rice, wheat, rape and Chinese milk vetch) to them...
November 8, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29126916/how-well-are-u-s-primary-care-providers-assessing-whether-their-male-patients-have-male-sex-partners
#10
Pollyanna R G Chávez, Laura G Wesolowski, Philip J Peters, Christopher H Johnson, Muazzam Nasrullah, Emeka Oraka, Euna M August, Elizabeth DiNenno
Identifying patients at-risk for HIV infection, such as men who have sex with men (MSM), is an important step in providing HIV testing and prevention interventions. It is unknown how primary care providers (PCPs) assess MSM status and related HIV-risk factors. We analyzed data from a panel-derived web-based survey for healthcare providers conducted in 2014 to describe how PCPs in the U.S. determined their patients' MSM status. We calculated adjusted prevalence ratios (aPR) and 95% confidence intervals (CI) to describe PCP characteristics associated with systematically determining MSM status (i...
November 7, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/29126084/a-simple-and-highly-selective-molecular-imprinting-polymer-based-methodology-for-propylparaben-monitoring-in-personal-care-products-and-industrial-waste-waters
#11
Ana Vicario, Leslie Aragón, Chien C Wang, Franco Bertolino, María R Gomez
In this work, a novel molecularly imprinted polymer (MIP) proposed as solid phase extraction sorbent was developed for the determination of propylparaben (PP) in diverse cosmetic samples. The use of parabens (PAs) is authorized by regulatory agencies as microbiological preservative; however, recently several studies claim that large-scale use of these preservatives can be a potential health risk and harmful to the environment. Diverse factors that influence on polymer synthesis were studied, including template, functional monomer, porogen and crosslinker used...
November 4, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29124043/activities-of-daily-living-measured-by-the-harvard-automated-phone-task-track-with-cognitive-decline-over-time-in-non-demented-elderly
#12
Gad A Marshall, Sarah L Aghjayan, Maria Dekhtyar, Joseph J Locascio, Kamal Jethwani, Rebecca E Amariglio, Keith A Johnson, Reisa A Sperling, Dorene M Rentz
Background: Impairment in activities of daily living is a major burden to both patients and caregivers. Mild impairment in instrumental activities of daily living is often seen at the stage of mild cognitive impairment. The field of Alzheimer's disease is moving toward earlier diagnosis and intervention and more sensitive and ecologically valid assessments of instrumental or complex activities of daily living are needed. The Harvard Automated Phone Task, a novel performance-based activities of daily living instrument, has the potential to fill this gap...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29122692/blockade-of-platelet-activating-factor-receptor-attenuates-abnormal-behaviors-induced-by-phencyclidine-in-mice-through-down-regulation-of-nf-%C3%AE%C2%BAb
#13
The-Vinh Tran, Se Jin Park, Eun-Joo Shin, Hai-Quyen Tran, Ji Hoon Jeong, Choon-Gon Jang, Yu Jeung Lee, Seung-Yeol Nah, Toshitaka Nabeshima, Hyoung-Chun Kim
Accumulating evidence suggests that neuroinflammation is one of the important etiologic factors of abusive and neuropsychiatric disorders. Platelet-activating factor (PAF) is potent proinflammatory lipid mediat1or and plays a pivotal role in neuroinflammatory disorders through the specific PAF receptor (PAF-R). Phencyclidine (PCP) induces a psychotomimetic state that closely resembles schizophrenia. Here, we investigated the role of PAF-R in the abnormal behaviors induced by PCP in mice. Repeated treatment with PCP resulted in a significant increase in PAF-R gene expression in the prefrontal cortex (PFC) and in the hippocampus...
November 6, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/29118102/phencyclidine-discoordinates-hippocampal-network-activity-but-not-place-fields
#14
Hsin-Yi Kao, Dino Dvořák, EunHye Park, Jana Kenney, Eduard Kelemen, André A Fenton
We used the psychotomimetic phencyclidine (PCP) to investigate the relationships between cognitive behavior, coordinated neural network function and information processing within the hippocampus place cell system. We report in rats that PCP (5mg/kg i.p.) impairs a well-learned hippocampus-dependent place avoidance behavior in rats that requires cognitive control, even when PCP is injected directly into dorsal hippocampus. PCP increases 60-100 Hz medium gamma oscillations in hippocampus CA1 and these increases correlate with the cognitive impairment caused by systemic PCP administration...
November 8, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29116181/leucine-repeat-adaptor-protein-1-interacts-with-dishevelled-to-regulate-gastrulation-cell-movements-in-zebrafish
#15
Xiao-Ning Cheng, Ming Shao, Ji-Tong Li, Yan-Fei Wang, Jing Qi, Zhi-Gang Xu, De-Li Shi
Gastrulation is a fundamental morphogenetic event that requires polarised cell behaviours for coordinated asymmetric cell movements. Wnt/PCP signalling plays a critical role in this process. Dishevelled is an important conserved scaffold protein that relays Wnt/PCP signals from membrane receptors to the modulation of cytoskeleton organisation. However, it remains unclear how its activity is regulated for the activation of downstream effectors. Here, we report that Lurap1 is a Dishevelled-interacting protein that regulates Wnt/PCP signalling in convergence and extension movements during vertebrate gastrulation...
November 7, 2017: Nature Communications
https://www.readbyqxmd.com/read/29114213/visually-evoked-visual-auditory-changes-associated-with-auditory-performance-in-children-with-cochlear-implants
#16
Maojin Liang, Junpeng Zhang, Jiahao Liu, Yuebo Chen, Yuexin Cai, Xianjun Wang, Junbo Wang, Xueyuan Zhang, Suijun Chen, Xianghui Li, Ling Chen, Yiqing Zheng
Activation of the auditory cortex by visual stimuli has been reported in deaf children. In cochlear implant (CI) patients, a residual, more intense cortical activation in the frontotemporal areas in response to photo stimuli was found to be positively associated with poor auditory performance. Our study aimed to investigate the mechanism by which visual processing in CI users activates the auditory-associated cortex during the period after cochlear implantation as well as its relation to CI outcomes. Twenty prelingually deaf children with CI were recruited...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29112975/referral-determinants-in-swiss-primary-care-with-a-special-focus-on-managed-care
#17
Ryan Tandjung, Seraina Morell, Andreas Hanhart, Andreas Haefeli, Fabio Valeri, Thomas Rosemann, Oliver Senn
Studies have shown large variation of referral probabilities in different countries, and many influencing factors have been described. This variation is most likely explained by different healthcare systems, particularly to which extent primary care physicians (PCPs) act as gatekeepers. In Switzerland no mandatory gatekeeping system exists, however insurance companies offer voluntary managed care plans with reduced insurance premiums. We aimed at investigating the role of managed care plans as a potential referral determinant in a non-gatekeeping healthcare system...
2017: PloS One
https://www.readbyqxmd.com/read/29111415/the-planar-cell-polarity-vangl2-protein-from-genetics-to-cellular-and-molecular-functions
#18
REVIEW
Eric Bailly, Alexandra Walton, Jean-Paul Borg
Planar cell polarity (PCP) refers to the capacity of a tissue, typically, but not exclusively, an epithelium, to transmit directional information across the tissue plane such that its cellular constituents can differentiate, divide or move in a coordinated manner and along a common axis, generally orthogonal to the apical-basal axis. PCP relies on a core module of highly conserved proteins originally identified in Drosophila which can act intra- and extracellularly. In this review, we focuse on the vertebrate ortholog of one of these core PCP components, namely the Vangl2 protein...
October 27, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29107170/cellular-and-molecular-mechanisms-underlying-planar-cell-polarity-pathway-contributions-to-cancer-malignancy
#19
REVIEW
Kaceauy VanderVorst, Jason Hatakeyama, Anastasia Berg, Hyun Lee, Kermit L Carraway
While the mutational activation of oncogenes drives tumor initiation and growth by promoting cellular transformation and proliferation, increasing evidence suggests that the subsequent re-engagement of largely dormant developmental pathways contributes to cellular phenotypes associated with the malignancy of solid tumors. Genetic studies from a variety of organisms have defined many of the components that maintain epithelial planar cell polarity (PCP), or cellular polarity in the axis orthogonal to the apical-basal axis...
October 26, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29104044/calcitonin-potentiates-the-anticonvulsant-and-antinociceptive-effects-of-valproic-acid-and-pregabalin-in-pentylenetetrazole-kindled-mice
#20
Nada M Hamada, Rehab H Ashour, Amany A Shalaby, Hussien M El-Beltagi
Antiepileptic drugs are the backbone for epilepsy management. Epilepsy may be accompanied by decreased pain threshold. Thus, anticonvulsant agents with antinociceptive properties are of great importance. This study investigated the possible anticonvulsant and antinociceptive effects of calcitonin in combination with either valproic acid or pregabalin and whether these effects might occur through γ-aminobutyric acid (GABA) modulation. Eighty-four male Balb/C mice were divided into 7 groups: control-naïve, pentylenetetrazole (PTZ)-induced seizures, PTZ-calcitonin, PTZ-valproic acid, PTZ-pregabalin, PTZ-calcitonin-valproic acid (PCV) combination, and PTZ-calcitonin-pregabalin (PCP) combination...
November 2, 2017: European Journal of Pharmacology
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