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https://www.readbyqxmd.com/read/29779005/hbv-and-hcv-test-uptake-and-correlates-among-men-who-have-sex-with-men-in-china-a-nationwide-cross-sectional-online-survey
#1
Thomas Fitzpatrick, Stephen W Pan, Weiming Tang, Wilson Guo, Joseph D Tucker
OBJECTIVES: Hepatitis B virus (HBV) and hepatitis C virus (HCV) cause substantial morbidity and mortality in low-income and middle-income countries, including China. WHO guidelines recommend men who have sex with men (MSM) receive HBV and HCV screening. The purpose of this study was to determine the proportion of MSM in China who have HBV and HCV tested and identify correlates of test uptake. METHODS: We conducted an online cross-sectional survey of young MSM in China...
May 19, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29778223/circadian-and-irradiance-effects-on-expression-of-antenna-protein-genes-and-pigment-contents-in-dinoflagellate-prorocentrum-donghaiense-dinophycae
#2
Xinguo Shi, Ling Li, Senjie Lin
PCP and acpPC are the two major antennae proteins that bind pigments in peridinin-containing dinoflagellates. The relationship between antennae proteins and cellular pigments at molecular level is still poorly understood. Here we identified and characterized the two antennae protein genes in dinoflagellate Prorocentrum donghaiense under different light conditions. The mature PCP protein was 32 kDa, while acpPC was a polyprotein each of 19 kDa. Both genes showed higher expression under low light than under high light, suggesting their possible role in a low light adaptation mechanism...
May 2018: Harmful Algae
https://www.readbyqxmd.com/read/29775079/improved-glycemic-control-with-minimal-change-in-medication-regimen-complexity-in-a-pharmacist-endocrinologist-diabetes-intense-medical-management-dimm-tune-up-clinic
#3
Candis M Morello, Taylor Rotunno, John Khoan, Jan D Hirsch
BACKGROUND: Gaining glycemic control in patients with type 2 diabetes (T2D) usually requires more complicated medication regimens. Increased medication regimen complexity (MRC) negatively impacts adherence and clinical outcomes. OBJECTIVE: Compare MRC change in patients with uncontrolled T2D referred to a collaborative pharmacist-endocrinologist Diabetes Intense Medical Management (DIMM) clinic "tune up" model versus similar patients receiving usual primary care provider (PCP) care over 6 months...
May 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29774644/storage-of-co%C3%A2-into-porous-coordination-polymer-controlled-by-molecular-rotor-dynamics
#4
Munehiro Inukai, Masanori Tamura, Satoshi Horike, Masakazu Higuchi, Susumu Kitagawa, Koichi Nakamura
Design to store gas molecules, such as CO₂, H₂, and CH₄, under low pressure is one of the most important challenges in chemistry and materials science. Herein, we describe the storage of CO₂ in the cavities of a porous coordination polymer (PCP) using molecular rotor dynamics. Owing to the narrow pore windows of PCP, CO₂ was not adsorbed at 195 K. As the temperature increased, the rotors exhibited rotational modes; such rotations dynamically expanded the size of the windows, leading to CO₂ adsorption...
May 18, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29772239/small-gtpase-r-ras-participates-in-neural-tube-formation-in-zebrafish-embryonic-spinal-cord
#5
Shinya Ohata, Hideko Uga, Hitoshi Okamoto, Toshiaki Katada
Ras related (R-Ras), a small GTPase, is involved in the maintenance of apico-basal polarity in neuroepithelial cells of the zebrafish hindbrain, axonal collapse in cultured murine hippocampal neurons, and maturation of blood vessels in adult mice. However, the role of R-Ras in neural tube formation remains unknown. Using antisense morpholino oligonucleotides (AMOs), we found that in the spinal cord of zebrafish embryos, the lumen was formed bilaterally in rras morphants, whereas it was formed at the midline in control embryos...
May 14, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29771337/randomized-trial-of-the-impact-of-empowering-childhood-cancer-survivors-with-survivorship-care-plans
#6
Nina S Kadan-Lottick, Wilhelmenia L Ross, Hannah-Rose Mitchell, Jaime Rotatori, Cary P Gross, Xiaomei Ma
Background: A survivorship care plan (SCP), that is, individualized treatment summary and schedule of off-therapy surveillance, will be mandated by January 2019. It is unclear whether SCPs improve adherence to recommended follow-up care in the community. In this trial, we evaluated the impact of randomly assigning childhood cancer survivors to 1) SCPs to be taken to their primary care physician (PCP) to implement or 2) survivorship clinic (SC) on health care quality measures. Methods: Eligibility included cancer diagnosis younger than age 18 years (2000-2012), cancer free, one or more years off therapy, and no prior survivorship clinic attendance...
May 15, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29769531/myosin1d-is-an-evolutionarily-conserved-regulator-of-animal-left-right-asymmetry
#7
Thomas Juan, Charles Géminard, Jean-Baptiste Coutelis, Delphine Cerezo, Sophie Polès, Stéphane Noselli, Maximilian Fürthauer
The establishment of left-right (LR) asymmetry is fundamental to animal development, but the identification of a unifying mechanism establishing laterality across different phyla has remained elusive. A cilia-driven, directional fluid flow is important for symmetry breaking in numerous vertebrates, including zebrafish. Alternatively, LR asymmetry can be established independently of cilia, notably through the intrinsic chirality of the acto-myosin cytoskeleton. Here, we show that Myosin1D (Myo1D), a previously identified regulator of Drosophila LR asymmetry, is essential for the formation and function of the zebrafish LR organizer (LRO), Kupffer's vesicle (KV)...
May 16, 2018: Nature Communications
https://www.readbyqxmd.com/read/29763762/removal-of-pcdd-fs-pcp-and-mercury-from-sediments-thermal-oxidation-versus-pyrolysis
#8
Moo-Been Chang, Yen-Chen Hsu, Shu-Hao Chang
A continuous pilot-scale system (CPS) equipped with effective air pollution control devices (APCDs) is used for remediating the sediments contaminated with PCDD/Fs, PCP and Hg simultaneously. The removal efficiencies of these three pollutants in sediments collected from seawater pond and river, respectively, are evaluated via thermal treatment processes. PAHs and CBz formed during thermal oxidation and pyrolysis are also analyzed for better understanding the behaviors of chlorinated organic compounds. Experimental results indicate that low-molecular-weight PAHs are closely related to the formation of CBz, PCDD/Fs, and CPs, while low chlorinated PCDD/Fs and CBz are predominant in flue gas with thermal oxidation...
May 7, 2018: Chemosphere
https://www.readbyqxmd.com/read/29763637/neurosteroid-pregnenolone-sulfate-alone-and-as-augmentation-of-lurasidone-or-tandospirone-rescues-phencyclidine-induced-deficits-in-cognitive-function-and-social-interaction
#9
L Rajagopal, D Soni, H Y Meltzer
BACKGROUND: Pregnenolone sulfate (PregS), an endogenous neurosteroid, which negatively and positively modulates gamma amino butyric acid subunit A (GABAA ) and N-methyl D-aspartate (NMDA) receptors (R) respectively, among other potential neuroplastic changes on synaptic processes, has shown some beneficial effects on treating cognitive impairment associated with schizophrenia (CIAS) and negative symptoms. Lurasidone (Lur), an atypical antipsychotic drug (AAPD), and tandospirone (Tan), a 5-HT1A  R partial agonist, have also been reported to improve cognitive or negative symptoms, or both, in some schizophrenia patients...
May 12, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29760830/patient-and-provider-perspectives-on-adherence-to-and-care-coordination-of-lynch-syndrome-surveillance-recommendations-findings-from-qualitative-interviews
#10
Jennifer L Schneider, Katrina A B Goddard, Kristin R Muessig, James V Davis, Alan F Rope, Jessica E Hunter, Susan K Peterson, Louise S Acheson, Sapna Syngal, Georgia L Wiesner, Jacob A Reiss
Background: Patients with a genetic variant associated with Lynch syndrome (LS) are recommended to undergo frequent and repeated cancer surveillance activities to minimize cancer-related morbidity and mortality. Little is known about how patients and primary care providers (PCPs) track and manage these recommendations. We conducted a small exploratory study of patient and PCP experiences with recommended LS surveillance activities and communication with family members in an integrated health care system...
2018: Hereditary Cancer in Clinical Practice
https://www.readbyqxmd.com/read/29760142/-in-vitro-and-in-vivo-activity-of-peptidomimetic-compounds-that-target-the-periodontal-pathogen-porphyromonas-gingivalis
#11
Jinlian Tan, Pravin C Patil, Frederick A Luzzio, Donald R Demuth
The interaction of the periodontal pathogen Porphyromonas gingivalis with oral streptococci is important for initial colonization of the oral cavity by P. gingivalis and is mediated by a discrete motif of the streptococcal antigen I/II protein. A synthetic peptide encompassing this motif functions as a potent inhibitor of P. gingivalis adherence but the use of peptides as topically applied therapeutic agents in the oral cavity has limitations arising from the relatively high cost of peptide synthesis and their susceptibility to degradation by proteases expressed by oral organisms...
May 14, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29758044/prickle-is-phosphorylated-by-nemo-and-targeted-for-degradation-to-maintain-prickle-spiny-legs-isoform-balance-during-planar-cell-polarity-establishment
#12
Giovanna M Collu, Andreas Jenny, Konstantin Gaengel, Ivana Mirkovic, Mei-Ling Chin, Ursula Weber, Michael J Smith, Marek Mlodzik
Planar cell polarity (PCP) instructs tissue patterning in a wide range of organisms from fruit flies to humans. PCP signaling coordinates cell behavior across tissues and is integrated by cells to couple cell fate identity with position in a developing tissue. In the fly eye, PCP signaling is required for the specification of R3 and R4 photoreceptors based upon their positioning relative to the dorso-ventral axis. The 'core' PCP pathway involves the asymmetric localization of two distinct membrane-bound complexes, one containing Frizzled (Fz, required in R3) and the other Van Gogh (Vang, required in R4)...
May 14, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29757843/strategies-used-to-facilitate-the-discussion-of-advance-care-planning-with-older-adults-in-primary-care-settings-a-literature-review
#13
Guillermina R Solis, Bibiana M Mancera, Megan Johnson Shen
BACKGROUND AND PURPOSE: The purpose of this literature review was to evaluate strategies used in primary care settings to initiate advance care planning (ACP) conversations leading to the completion of an advance directive (AD). Approximately 50% of older adults have an AD; few talk to their primary care provider (PCP) about end-of-life wishes. The Institute of Medicine report and recent changes in Medicare reimbursement policies create opportunities for PCPs to address ACP in primary care settings...
May 2018: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/29756260/membrane-trafficking-in-morphogenesis-and-planar-polarity
#14
REVIEW
Yi Xie, Hui Miao, J Todd Blankenship
Our understanding of how membrane trafficking pathways function to direct morphogenetic movements and the planar polarization of developing tissues is a new and emerging field. While a central focus of developmental biology has been on how protein asymmetries and cytoskeletal force generation direct cell shaping, the role of membrane trafficking in these processes has been less clear. Here, we review recent advances in Drosophila and vertebrate systems in our understanding of how trafficking events are coordinated with planar cytoskeletal function to drive lasting changes in cell and tissue topologies...
May 14, 2018: Traffic
https://www.readbyqxmd.com/read/29756183/effects-of-heavy-metal-species-concentrations-and-speciation-on-pentachlorophenol-sorption-by-river-biofilms
#15
Xiuyi Hua, Liting Wang, Liwen Zhang, Deming Dong, Zhiyong Guo
The sorption of trace organic pollutants at solid/liquid interfaces is one of the most important processes that influence their fate and behaviours in the aquatic environment. Sorption is affected by coexisting contaminants. The process and extent to which coexisting heavy metals affect the sorption of organochlorine pesticides (OCPs), especially acid radical anion heavy metals, are still unclear. Here, the effects of the species, concentrations, and speciation of the heavy metals Cu, Pb, and Cr, and the metalloid As on the sorption of pentachlorophenol (PCP), as a model OCP, by river biofilms were investigated through batch experiments...
May 13, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29751779/essential-role-of-atp6ap2-enrichment-in-caveolae-lipid-raft-microdomains-for-the-induction-of-neuronal-differentiation-of-stem-cells
#16
Nehman Makdissy, Katia Haddad, Jeanne D'arc AlBacha, Diana Chaker, Bassel Ismail, Albert Azar, Ghada Oreibi, David Ayoub, Ibrahim Achkar, Didier Quilliot, Ziad Fajloun
BACKGROUND: The subcellular distribution of prorenin receptor and adaptor protein ATP6AP2 may affect neurogenesis. In this study, we hypothesized that ATP6AP2 expression and subcellular relocalization from caveolae/lipid raft microdomains (CLR-Ms) to intracellular sites may correlate with neuronal differentiation (Neu-Dif) of adipose-derived mesenchymal stem cells (ADSCs). METHODS: Human ADSCs isolated from 24 healthy donors and 24 patients with neurological disorders (ND) were cultured and induced for Neu-Dif...
May 11, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29744678/correction-to-seasonal-variations-of-pcdd-fs-in-fishes-inferring-a-hidden-exposure-route-from-na-pcp-application-for-schistosomiasis-control
#17
Yuming Hu, Chuanzhu Yi, Jingguang Li, Xiaohong Shang, Zimin Li, Xiaochen Yin, Bo Chen, Yuechan Zhou, Yinyin Zhang, Yongning Wu
The original version of this article unfortunately contained an error in the affiliation section.
May 7, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29742747/improving-the-signal-to-noise-ratio-when-monitoring-countermovement-jump-performance
#18
Rodney A Kennedy, David Drake
Kennedy, RA and Drake, D. Improving the signal-to-noise ratio when monitoring countermovement jump performance. J Strength Cond Res XX(X): 000-000, 2018-Countermovement jump (CMJ) performance has been routinely used to monitor neuromuscular status. However, the protocol used to establish the criterion score is not well documented. The purpose of this study was to examine how the protocol used would influence of the sensitivity of CMJ variables in rugby union players. Fifteen male (age: 19.7 ± 0.5 years) rugby union players performed 8 CMJs on 2 occasions, separated by 7 days...
May 8, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29739688/resources-to-handle-childhood-asthma-in-spain-the-role-of-plans-and-guides-and-the-participation-of-nurses
#19
M I Úbeda-Sansano, A Cano-Garcinuño, S Rueda-Esteban, M Praena-Crespo
BACKGROUND: Describe the assistance provided to asthmatic patients by Primary Care Paediatricians (PCP) in Spain and the material and human resources available for diagnosis and follow-up. METHODS: A cross-sectional descriptive study using an on-line survey, sent to PCP regarding the availability of diagnostic resources, carrying out programmed and educational activities, collaboration of nursing staff and their relationship with existing institutional plans to care for children with asthma...
May 5, 2018: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29739409/how-health-system-factors-affect-primary-care-practitioners-decisions-to-refer-patients-for-further-investigation-protocol-for-a-pan-european-ecological-study
#20
Michael Harris, Gordon Taylor
BACKGROUND: There is wide variation in the overall one-year relative cancer survival rates across Europe, and this is thought to indicate national variations in stage of disease at diagnosis. However, there is little evidence to explain how different national systems influence a primary care practitioner's (PCP's) referral decisions, and how these relate to the variation in survival rates. This study investigates the health system factors that influence the thinking of PCPs when faced with patients who may have cancer, how they compare across European countries, and how they relate to national one-year relative cancer relative survival rates...
May 8, 2018: BMC Health Services Research
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