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https://www.readbyqxmd.com/read/28937876/pilot-study-of-the-pulsatile-neuro-peripapillary-retinal-deformation-in-glaucoma-and-its-relationship-with-glaucoma-risk-factors
#1
Maribel Hidalgo-Aguirre, Santiago Costantino, Mark Richard Lesk
PURPOSE: To perform a pilot study of the neuro-peripapillary retinal tissue deformation during the cardiac cycle among healthy eyes, ocular hypertensive (OHT), open angle glaucoma suspect (OAG-S), and early open angle glaucoma (EOAG) patients using video rate optical coherence tomography (OCT) image series. METHODS: OCT line scan sequences of the same region of the optic nerve head (ONH) were obtained from 15 EOAG, 6 OHT, 10 OAG-S, and 10 healthy age-matched eyes...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28937859/choroidal-thickness-in-traumatic-optic-neuropathy
#2
Ju-Yeun Lee, Doo-Ri Eo, Kyung-Ah Park, Sei Yeul Oh
PURPOSE: To examine the choroidal thickness in patients with indirect traumatic optic neuropathy (TON) Methods: Patients with unilateral traumatic optic neuropathy over a period of 4 years were included in this study. Horizontal and vertical enhanced-depth imaging (EDI) from spectral-domain optical coherence tomography (SD-OCT) scans of the fovea were obtained in patients with unilateral TON within 2 weeks of injury. The main outcome measure was the choroidal thickness at nine locations...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28931299/-steroid-induced-glaucoma-as-a-complication-of-atopic-eczema-local-treatment
#3
T Řeháková, A Stepanov, N Jirásková
The authors present case reports of two young women, who visited the outpatient Department of Ophthalmology clinic, University Hospital in Hradec Králové with lacklustre subjective eye complaints lasting over few weeks. It the beginning high values of intraocular pressure in both eyes and severe glaucomatous damage of the optic nerve head were find out, which was confirm using perimetry and OCT (optical coherence tomography). The anamnesis has shown that both patients have been treated for atopic eczema since their childhood...
2017: Ceská a Slovenská Oftalmologie
https://www.readbyqxmd.com/read/28928966/optical-coherence-tomography-angiography-in-glaucoma-a-mini-review
#4
REVIEW
Kelvin H Wan, Christopher K S Leung
The advent of optical coherence tomography angiography (OCT-A) provides a new opportunity to visualize the retinal vasculature in a non-invasive and dye-free manner which may help identify vascular abnormalities in glaucoma. While a reduction in retinal and optic nerve head vessel densities and blood flow indexes measured by OCT-A has been demonstrated in patients with glaucoma in many studies, it is unclear whether OCT-A provides additional information for the detection and monitoring of glaucoma compared with OCT measurements such as retinal nerve fiber layer thickness, neuroretinal rim width, and ganglion cell inner plexiform layer thickness...
2017: F1000Research
https://www.readbyqxmd.com/read/28922031/optic-nerve-head-characteristics-in-chronic-angle-closure-glaucoma-detected-by-swept-source-oct
#5
Dejiao Li, Taibo Li, Eleftherios I Paschalis, Haobing Wang, Elise V Taniguchi, Zi-Ning Choo, Marissa K Shoji, Scott H Greenstein, Stacey C Brauner, Angela V Turalba, Louis R Pasquale, Lucy Q Shen
PURPOSE: To compare structural features in prelaminar and laminar tissues of the optic nerve head (ONH) in chronic angle closure glaucoma (CACG), primary open angle glaucoma (POAG), and control subjects. MATERIALS AND METHODS: ONH imaging was performed using swept-source optical coherence tomography (SS-OCT) for measurements of minimum rim width at Bruch's membrane opening (BMO-MRW), horizontal, and vertical lamina cribrosa depth (LCD). Prelaminar defects, categorized as hole and wedge, and lamina cribrosa (LC) defects were identified...
September 18, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28910159/glaucoma-diagnostic-ability-of-the-optical-coherence-tomography-angiography-vessel-density-parameters
#6
Jae Keun Chung, Young Hoon Hwang, Jae Min Wi, Mijin Kim, Jong Jin Jung
PURPOSE: To investigate the glaucoma diagnostic abilities of vessel density parameters as determined by optical coherence tomography (OCT) angiography in different stages of glaucoma. MATERIALS AND METHODS: A total of 113 healthy eyes and 140 glaucomatous eyes were enrolled. Diagnostic abilities of the OCT vessel density parameters in the optic nerve head (ONH), peripapillary, and macular regions were evaluated by calculating the area under the receiver operation characteristic curves (AUCs)...
September 14, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28885451/visual-structure-and-function-in-collision-sport-athletes
#7
Danielle Leong, Christina Morettin, Leonard V Messner, Robert J Steinmetz, Yi Pang, Steven L Galetta, Laura J Balcer
BACKGROUND: Vision-based measures have been shown to be useful markers in multiple sclerosis (MS), Alzheimer and Parkinson disease. Therefore, these testing paradigms may have applications to populations explaining repetitive head trauma that has been associated with long-term neurodegenerative sequelae. We investigated retinal structure and visual function in professional collision sport athletes compared to age- and race-matched control participants. METHODS: In this cross-sectional study, participants underwent spectral-domain optical coherence tomography (OCT) measurements of peripapillary retinal nerve fiber layer (RNFL) and macular ganglion cell complex (GCC = ganglion cell + inner plexiform layers) thickness...
September 6, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/28877529/retinal-nerve-fiber-layer-thickness-changes-in-the-pseudoexfoliation-syndrome-a-meta-analysis-of-case-control-studies
#8
Ji-Guo Yu, Qing Huang, Xiao-Fang Zhou, Yi Ding, Jing Li, Yi Xiang
PURPOSE: To evaluate and compare changes in retinal nerve fiber layer (RNFL) thickness in patients with the pseudoexfoliation syndrome (PXS) and healthy controls. METHODS: Case-control studies were selected through an electronic search of the Cochrane Controlled Trials Register, PubMed, and Embase. Results were reviewed to ensure that the included studies met prespecified inclusion/exclusion criteria, and the quality of each study was assessed using the Newcastle-Ottawa Scale...
September 7, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/28875349/variations-in-optic-nerve-head-morphology-by-intraocular-pressure-in-open-angle-glaucoma
#9
Aaron Wong, Kaliopy Matheos, Zak Prime, Helen V Danesh-Meyer
PURPOSE: To compare optic disc topography in eyes in three intraocular pressure (IOP) groups of <15 mmHg, 15-20 mmHg, and ≥21 mmHg using spectral domain optical coherence tomography (SD-OCT) and confocal scanning laser ophthalmoscopy, adjusting for the degree of damage, as measured by retinal nerve fiber layer (RNFL) thickness and average visual field loss. METHODS: A total of 184 eyes of 112 patients with primary open-angle glaucoma were recruited into groups based on baseline untreated intraocular pressure (IOP) of <15 mmHg (normal-tension glaucoma [NTG], very low), 15-20 mmHg (NTG, medium), or ≥21 mmHg (high-tension glaucoma [HTG])...
September 5, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28862734/utility-of-bruch-membrane-opening-based-optic-nerve-head-parameters-in-myopic-subjects
#10
Marina Sastre-Ibañez, Jose M Martinez-de-la-Casa, Gema Rebolleda, Pilar Cifuentes-Canorea, Maria Nieves-Moreno, Laura Morales-Fernandez, Federico Saenz-Frances, Julian Garcia-Feijoo
PURPOSE: To evaluate whether the new rim analysis software with spectral-domain optical coherence tomography (SD-OCT) shows advantages over the retinal nerve fiber layer (RNFL) thickness in patients with moderate myopia. METHODS: In this prospective cross-sectional study, we studied 65 healthy subjects, 37 with spherical refractive errors in the range of -3 to -6 D (moderate, G1) and 28 with less than -3 D (low/non-myopic, G0). All patients were examined with Heidelberg Spectralis SD-OCT, including Glaucoma Premium Module Edition (GPME) software...
August 11, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28861697/optical-coherence-tomography-angiography-in-acute-arteritic-and-non-arteritic-anterior-ischemic-optic-neuropathy
#11
Nicole Balducci, Mariachiara Morara, Chiara Veronese, Piero Barboni, Nicoletta Lelli Casadei, Giacomo Savini, Vincenzo Parisi, Alfredo A Sadun, Antonio Ciardella
PURPOSE: The purpose of our study was to describe the feature of acute non-arteritic or arteritic anterior ischemic optic neuropathy (NA-AION and A-AION) using optical coherence tomography angiography (OCT-A) and to compare it with fluorescein angiography (FA) and indocyanine green angiography (ICGA). METHODS: In this retrospective, observational case-control study four NA-AION patients and one A-AION patient were examined by FA, ICGA and OCT-A within 2 weeks from disease presentation...
August 31, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28858159/reproducibility-of-optical-coherence-tomography-angiography-macular-and-optic-nerve-head-vascular-density-in-glaucoma-and-healthy-eyes
#12
Patricia Isabel C Manalastas, Linda M Zangwill, Luke J Saunders, Kaweh Mansouri, Akram Belghith, Min Hee Suh, Adeleh Yarmohammadi, Rafaella C Penteado, Tadamichi Akagi, Takuhei Shoji, Robert N Weinreb
PURPOSE: Optical coherence tomography angiography (OCT-A) is a non-invasive technology that allows visualization of retinal blood vessels. It is important to determine reproducibility of measurements as low precision can impair its diagnostic capabilities. The purpose of this study is to determine intra-visit and inter-visit reproducibility of optic nerve head (ONH) and macular vessel density measurements with OCT-A. PATIENTS AND METHODS: Fifteen healthy volunteers and fourteen glaucoma patients completed two OCT-A (AngioVue; Optovue Inc...
August 28, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28858153/attenuation-coefficients-from-sd-oct-data-structural-information-beyond-morphology-on-rnfl-integrity-in-glaucoma
#13
Gijs Thepass, Hans G Lemij, Koenraad A Vermeer
PURPOSE: To explore the attenuation coefficient (AC) of the retinal nerve fiber layer (RNFL) in spectral domain optical coherence tomography (OCT) images, in healthy eyes and eyes affected by glaucoma. To assess the relation between RNLF AC, disease severity, RNFL thickness, visual field sensitivity threshold, spatial location and age. PATIENTS AND METHODS: We analyzed peripapillary circle scans of a clinical OCT device (Spectralis OCT, Heidelberg Engineering, Heidelberg, Germany) in 102 glaucoma patients and 90 healthy controls...
August 28, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28857944/volumetric-measurement-of-optic-nerve-head-drusen-using-swept-source-optical-coherence-tomography
#14
Edem Tsikata, Alice C Vercellin Verticchio, Iryna Falkenstein, Linda Yi-Chieh Poon, Stacey Brauner, Ziad Khoueir, John B Miller, Teresa C Chen
PURPOSE: To describe new software tools for quantifying optic nerve head drusen volume using 3-dimensional (3D) swept-source optical coherence tomography (SS-OCT) volumetric scans. MATERIALS AND METHODS: SS-OCT was used to acquire raster volume scans of 8 eyes of 4 patients with bilateral optic nerve head drusen. The scans were manually segmented by 3 graders to identify the drusen borders, and thereafter total drusen volumes were calculated. Linear regression was performed to study the relationships between drusen volume, retinal nerve fiber layer thickness, and Humphrey visual field mean deviation...
September 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28857943/visibility-of-optic-nerve-head-structures-with-spectral-domain-and-swept-source-optical-coherence-tomography
#15
Mónica M Loureiro, Jayme R Vianna, Vishva M Danthurebandara, Glen P Sharpe, Donna M Hutchison, Marcelo T Nicolela, Balwantray C Chauhan
PURPOSE: To compare the visibility of deep optic nerve head (ONH) structures and the visible area of the anterior surface of the lamina cribrosa (ASLC) with spectral-domain optical coherence tomography (SD-OCT) and swept-source OCT (SS-OCT). MATERIALS AND METHODS: In total, 33 glaucoma patients were imaged with SD-OCT (Spectralis, 24 radial B-scans centered on the ONH) and SS-OCT (Atlantis, 12 radial and a horizontal and vertical raster scan pattern containing 5 lines each, centered on the ONH)...
September 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28855629/location-of-the-central-retinal-vessel-trunk-in-the-laminar-and-prelaminar-tissue-of-healthy-and-glaucomatous-eyes
#16
Bo Wang, Katie A Lucy, Joel S Schuman, Hiroshi Ishikawa, Richard A Bilonick, Ian A Sigal, Larry Kagemann, Chen Lu, James G Fujimoto, Gadi Wollstein
Glaucoma is a leading cause of blindness that leads to characteristic changes in the optic nerve head (ONH) region, such as nasalization of vessels. It is unknown whether the spatial location of this vessel shift inside the ONH occurs within the lamina cribrosa (LC) or the prelaminar tissue. The purpose of this study was to compare the location of the central retinal vessel trunk (CRVT) in the LC and prelaminar tissue in living healthy and glaucomatous eyes. We acquired 3-dimensional ONH scans from 119 eyes (40 healthy, 29 glaucoma suspect, and 50 glaucoma) using optical coherence tomography (OCT)...
August 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28832670/peripapillary-retinal-splitting-visualized-on-oct-in-glaucoma-and-glaucoma-suspect-patients
#17
Dilraj S Grewal, Daniel J Merlau, Pushpanjali Giri, Marion R Munk, Amani A Fawzi, Lee M Jampol, Angelo P Tanna
PURPOSE: To identify the risk factors for development of peripapillary retinal splitting (schisis) in patients with glaucoma or suspicion of glaucoma. SETTING: Glaucoma Clinic, Department of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, IL. METHODS: In this institutional cross-sectional study, 495 patients (990 eyes) who had undergone spectral-domain optical coherence tomography (OCT Spectralis HRA-OCT, Heidelberg Engineering) optic nerve head (ONH) imaging and did not have identifiable optic nerve pits, pseudopits or coloboma were included...
2017: PloS One
https://www.readbyqxmd.com/read/28828484/presence-of-peripheral-neuropathy-is-associated-with-progressive-thinning-of-retinal-nerve-fiber-layer-in-type-1-diabetes
#18
Cirous Dehghani, Sangeetha Srinivasan, Katie Edwards, Nicola Pritchard, Anthony W Russell, Rayaz A Malik, Nathan Efron
Purpose: Reduced retinal nerve fiber layer (RNFL) thickness has been demonstrated in patients with diabetic peripheral neuropathy (DPN) in cross-sectional studies. This prospective study defines longitudinal alterations to the RNFL thickness in individuals with type 1 diabetes without (DPN-ve) and with (DPN+ve) DPN and in relation to risk factors for nerve damage. Methods: A cohort of 105 individuals with type 1 diabetes (20% DPN+ve) with predominantly mild or no retinopathy and no previous retinal photocoagulation underwent spectral-domain optical coherence tomography (SD-OCT) at baseline, 2 years, and 4 years...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28820625/multimodal-image-analysis-of-the-retina-in-hunter-syndrome-mucopolysaccharidosis-type-ii-case-report
#19
Isadora Darriba Macedo Salvucci, Simone Finzi, Maria Kiyoko Oyamada, Chong Ae Kim, Sérgio Luis Gianotti Pimentel
INTRODUCTION: We report a case of retinal and posterior ocular findings in a 33-year-old man diagnosed with Hunter syndrome (Mucopolysaccharidosis type II) in a multimodal imaging way. CASE PRESENTATION: Our patient was complaining of blurred night vision for the past 3 years. He had not received any systemic treatment for Hunter syndrome. Vision acuity was 20/20 in both eyes and corneas were clear. Fundus examination revealed bilateral crowded and hyperemic optic nerve heads (elevated in the ocular ultrasound) and areas of subretinal hypopigmentation...
August 18, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/28819712/optical-coherence-tomography-to-differentiate-papilledema-from-pseudopapilledema
#20
REVIEW
Gema Rebolleda, Aki Kawasaki, Victoria de Juan, Noelia Oblanca, Francisco Jose Muñoz-Negrete
PURPOSE OF REVIEW: Mild papilledema may be difficult to distinguish by clinical observation from pseudopapilledema. An accurate diagnosis is critical to avoid invasive workup and unwarranted treatment. In this review, we focus on the development and subsequent role of optical coherence tomography (OCT) in detecting and differentiating optic nerve head drusen (ONHD) from papilledema and other causes of acquired swelling of the optic disc. RECENT FINDINGS: Newer OCT technologies which permit deeper penetration to improve detection of ONHD were also reviewed...
August 17, 2017: Current Neurology and Neuroscience Reports
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