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https://www.readbyqxmd.com/read/28183830/diagnosis-and-management-of-secondary-epipapillary-retinoblastoma
#1
Ido Didi Fabian, Francesco Puccinelli, Marie-Claire Gaillard, Maja Beck-Popovic, Francis L Munier
BACKGROUND: Reports on retinoblastoma relapse at the optic nerve head (ONH) are anecdotal and include only treatments by external beam radiotherapy (EBRT) or enucleation. We aimed to describe such cases, termed secondary epipapillary retinoblastoma, diagnosed and monitored with the assistance of hand-held spectral domain optical coherence tomography (HHSD-OCT) and treated with intraophthalmic artery chemotherapy (IAC) and/or intravitreous chemotherapy (IViC). METHODS: A retrospective analysis of secondary epipapillary retinoblastoma cases treated conservatively...
February 9, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28174676/a-digital-staining-algorithm-for-optical-coherence-tomography-images-of-the-optic-nerve-head
#2
Jean-Martial Mari, Tin Aung, Ching-Yu Cheng, Nicholas G Strouthidis, Michaël J A Girard
PURPOSE: To digitally stain spectral-domain optical coherence tomography (OCT) images of the optic nerve head (ONH), and highlight either connective or neural tissues. METHODS: OCT volumes of the ONH were acquired from one eye of 10 healthy subjects. We processed all volumes with adaptive compensation to remove shadows and enhance deep tissue visibility. For each ONH, we identified the four most dissimilar pixel-intensity histograms, each of which was assumed to represent a tissue group...
February 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28169924/retrograde-maculopathy-in-patients-with-glaucoma
#3
Jacqueline Brazerol, Milko E Iliev, René Höhn, Stephan Fränkl, Hilary Grabe, Mathias Abegg
PURPOSE: Macular optical coherence tomography (OCT) analysis can be used for quantitative measures of optic nerve atrophy at a location far from the optic nerve head. This recently led to the finding of microcystic macular edema (MME), that is vacuolar inclusions in the macular inner nuclear layer, in some glaucoma patients. The involvement of individual retinal layers is yet unclear in glaucoma. In this study we systematically investigated glaucoma-induced changes in macular layers to evaluate whether glaucoma-associated damage extends beyond the macular ganglion cell layer...
February 6, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28152070/retinal-vessel-density-from-optical-coherence-tomography-angiography-to-differentiate-early-glaucoma-pre-perimetric-glaucoma-and-normal-eyes
#4
Handan Akil, Alex S Huang, Brian A Francis, Sirinivas R Sadda, Vikas Chopra
PURPOSE: To evaluate optic nerve vascular density using swept source optical coherence tomography angiography (OCTA) in patients with early primary open angle glaucoma (POAG), pre-perimetric glaucoma and normal eyes. METHODS: This is a prospective, observational study including 56 eyes in total and divided into 3 groups; 20 eyes with mild POAG, 20 pre-perimetric glaucoma eyes, and 16 age-matched normal eyes as controls. The optic disc region was imaged by a 1050-nm-wavelength swept-source OCT system (DRI OCT Triton, TOPCON)...
2017: PloS One
https://www.readbyqxmd.com/read/28150426/reproducibility-and-repeatability-of-optical-coherence-tomography-imaging-of-the-optic-nerve-head-in-normal-beagle-eyes
#5
Alexandra M Bemis, Christopher G Pirie, Alexander J LoPinto, Louise Maranda
OBJECTIVE: To assess the reproducibility and repeatability of an optical coherence tomography (OCT) device for imaging the optic nerve region of normal canines. ANIMALS STUDIED: Twelve clinically healthy beagles. PROCEDURES: All animals were anesthetized, and an OCT device was used to image the optic disk region. Total disk area and retinal nerve fiber layer (NFL) thickness in eight segments were obtained from each image. Images were collected by two operators in succession and each operator took five scans, repositioning the device between measurements...
February 1, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28141872/factors-associated-with-the-retinal-nerve-fiber-layer-loss-after-acute-primary-angle-closure-a-prospective-edi-oct-study
#6
Eun Ji Lee, Tae-Woo Kim, Kyoung Min Lee, Seung Hyen Lee, Hyunjoong Kim
PURPOSE: To determine the factors associated with retinal nerve fiber layer (RNFL) loss in eyes with acute primary angle-closure (APAC), particularly focusing on the influence of the change in the anterior lamina cribrosa surface depth (LCD). METHODS: After the initial presentation, 30 eyes with unilateral APAC were followed up at the following specific time points over a 12-month period: 1 week, 1~2 months, 2~3 months, 5~6 months, and 11~12 months. These follow-ups involved intraocular pressure measurements, enhanced depth-imaging spectral-domain optical coherence tomography (SD-OCT) scanning of the optic disc, and measurements of the circumpapillary RNFL thickness...
2017: PloS One
https://www.readbyqxmd.com/read/28098726/assessment-of-retinal-blood-flow-in-diabetic-retinopathy-using-doppler-fourier-domain-optical-coherence-tomography
#7
Sowmya Srinivas, Ou Tan, Muneeswar G Nittala, Jennifer L Wu, Amani A Fazwi, David Huang, SriniVas R Sadda
PURPOSE: To evaluate retinal blood flow measurements in normal eyes and eyes with varying levels of diabetic retinopathy (DR) using Doppler Fourier-domain optical coherence tomography (FD-OCT). METHODS: Twenty-two eyes of 19 subjects, 10 with severe nonproliferative DR (NPDR) and 12 with proliferative DR (PDR), were compared with 44 eyes of 40 healthy control subjects. All eyes were scanned by RTvue FD-OCT. Color disk photographs and cube/volume scans of the optic nerve head were obtained...
January 16, 2017: Retina
https://www.readbyqxmd.com/read/28040526/the-effect-of-treatment-of-idiopathic-intracranial-hypertension-on-prevalence-of-retinal-and-choroidal-folds
#8
Mark J Kupersmith, Patrick A Sibony, Steven E Feldon, Jui-Kai Wang, Mona Garvin, Randy Kardon
PURPOSE: We described 3 types of folds in the retina and a crease in the outer retina associated with papilledema due to idiopathic intracranial hypertension (IIH) at presentation. We report the change in folds relative to treatment of IIH over the six months. Design/Study Subjects: Substudy of a randomized clinical trial. METHODS: Study eyes of subjects assigned to acetazolamide (ACZ, n=44) or placebo (PLB, n=43) had spectral domain optical coherence tomography (SDOCT) images of the optic disc and macula regions at baseline, 3 and 6 months...
December 28, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28032805/nerve-fiber-layer-thickness-and-characteristics-associated-with-glaucoma-in-community-living-older-adults-prelude-to-a-screening-trial
#9
Barbara E K Klein, Chris A Johnson, Stacy M Meuer, Kyungmoo Lee, Andreas Wahle, Kristine E Lee, Amruta Kulkarni, Milan Sonka, Michael D Abràmoff, Ronald Klein
PURPOSE: To examine the associations of nerve fiber layer (NFL) thickness with other ocular characteristics in older adults. METHODS: Participants in the Beaver Dam Eye Study (2008-2010) underwent spectral domain optical coherence tomography (SD-OCT) scans of the optic nerve head, imaging of optic discs, frequency doubling technology (FDT) perimetry, measurement of intraocular pressure (IOP), and an interview concerning their history of glaucoma and use of drops to lower eye pressure...
December 29, 2016: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28009408/peripapillary-choroidal-thickness-by-enhanced-depth-imaging-optical-coherence-tomography-the-impact-of-metabolic-syndrome
#10
Mónica Loureiro, Ana Cristina Braga, Dália Meira, Paula Sepúlveda, Luís Agrelos, Paulo Torres
PURPOSE: To assess the impact of metabolic syndrome (MetS) on the peripapillary choroidal thickness (PPCT) and to characterize the PPCT in a Portuguese population. METHODS: This prospective study included 104 eyes. Detailed medical and ophthalmic examinations were performed; the PPCT was measured by spectral-domain optical coherence tomography (SD-OCT) using enhanced depth imaging (EDI) modality. The PPCT changes with MetS, as well as with other clinical and demographic factors, were investigated...
November 21, 2016: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28005675/swept-source-optical-coherence-tomography-angiography-of-the-optic-disk-in-optic-neuropathy
#11
Khalil Ghasemi Falavarjani, Jack J Tian, Handan Akil, Giancarlo A Garcia, Srinivas R Sadda, Alfredo A Sadun
PURPOSE: To evaluate the optic nerve head microvasculature in eyes with acute and chronic optic neuropathies using swept-source optical coherence tomography angiography. METHODS: In this cross-sectional, observational study, optical coherence tomography angiography images were obtained from the optic nerve heads of 21 eyes of 12 patients with optic disk edema, pseudoedema and atrophy, and 12 eyes of 6 healthy subjects using a 1,050-nm optical coherence tomography angiography (Topcon DRI OCT; Triton)...
December 2016: Retina
https://www.readbyqxmd.com/read/27928413/a-rare-case-of-unilateral-progressive-vision-loss-and-pachymeningitis
#12
Reuben Mari Valenzuela, Bonnie Keung, John H Pula, Jorge C Kattah
We describe a 32-year-old man with presumed Vogt-Koyanagi Harada (VKH) syndrome, whose presenting symptoms were headache and progressive loss of vision in the right eye. Neuro-ophthalmic examination showed anterior and posterior uveitis, and retinal detachment in the right eye. Ocular coherence tomography (OCT) showed extensive submacular fluid in the right eye, while the fundus fluorescein angiogram (FFA) confirmed perifoveal retinal pigment epithelium (RPE) disruption and multifocal fluorescein leakage in the right eye...
October 2016: Neuro-ophthalmology
https://www.readbyqxmd.com/read/27920413/retinal-nerve-fiber-layer-thickness-in-a-healthy-turkish-population-measured-by-optical-coherence-tomography
#13
Mehmet Cubuk, Nedime Sahinoglu-Keskek, Sakir Ozgur Keskek
BACKGROUND: Normative optical coherence tomography (OCT) data is required for different subsets of the population as ethnic differences in retinal nerve fiber layer (RNFL) thickness have been reported. An OCT database for the normal Turkish population is not commercially available. OBJECTIVES: Quantify peripapillary RNFL thickness in a Turkish population. DESIGN: Cross-sectional, descriptive study. SETTING: Numune Training and Research Hospital, Adana, Turkey...
November 2016: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/27916682/adaptive-optics-optical-coherence-tomography-in-glaucoma
#14
REVIEW
Zachary M Dong, Gadi Wollstein, Bo Wang, Joel S Schuman
Since the introduction of commercial optical coherence tomography (OCT) systems, the ophthalmic imaging modality has rapidly expanded and it has since changed the paradigm of visualization of the retina and revolutionized the management and diagnosis of neuro-retinal diseases, including glaucoma. OCT remains a dynamic and evolving imaging modality, growing from time-domain OCT to the improved spectral-domain OCT, adapting novel image analysis and processing methods, and onto the newer swept-source OCT and the implementation of adaptive optics (AO) into OCT...
December 1, 2016: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/27914988/imaging-of-macrophage-dynamics-with-optical-coherence-tomography-in-anterior-ischemic-optic-neuropathy
#15
Despina Kokona, Nathanael U Häner, Andreas Ebneter, Martin S Zinkernagel
Anterior ischemic optic neuropathy (AION) is a relatively common cause of visual loss and results from hypoperfusion of the small arteries of the anterior portion of the optic nerve. AION is the leading cause of sudden optic nerve related vision loss with approximately 10 cases per 100'000 in the population over 50 years. To date there is no established treatment for AION and therefore a better understanding of the events occurring at the level of the optic nerve head (ONH) would be important to design future therapeutic strategies...
November 30, 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27914831/optic-nerve-head-drusen-prevalence-and-associated-factors-in-clinically-normal-subjects-measured-using-optical-coherence-tomography
#16
Mark P Ghassibi, Jason L Chien, Ramiz K Abumasmah, Jeffrey M Liebmann, Robert Ritch, Sung Chul Park
OBJECTIVE: To investigate the prevalence of optic nerve head drusen (ONHD) in clinically normal subjects using enhanced depth imaging (EDI) optical coherence tomography (OCT) and to evaluate associated factors. DESIGN: Prospective, cross-sectional, observational study. PARTICIPANTS: Total of 130 clinically normal subjects. METHODS: Serial horizontal and vertical EDI OCT B-scans (interval between scans, ∼30 μm) of the optic nerve head (ONH) were obtained in both eyes of clinically normal subjects...
November 30, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27909833/verification-of-a-virtual-fields-method-to-extract-the-mechanical-properties-of-human-optic-nerve-head-tissues-in-vivo
#17
Liang Zhang, Sri Gowtham Thakku, Meghna R Beotra, Mani Baskaran, Tin Aung, James C H Goh, Nicholas G Strouthidis, Michael J A Girard
We aimed to verify a custom virtual fields method (VFM) to estimate the patient-specific biomechanical properties of human optic nerve head (ONH) tissues, given their full-field deformations induced by intraocular pressure (IOP). To verify the accuracy of VFM, we first generated 'artificial' ONH displacements from predetermined (known) ONH tissue biomechanical properties using finite element analysis. Using such deformations, if we are able to match back the known biomechanical properties, it would indicate that our VFM technique is accurate...
December 1, 2016: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/27906811/measurement-of-radial-peripapillary-capillary-density-in-the-normal-human-retina-using-optical-coherence-tomography-angiography
#18
Tarannum Mansoori, Jayanthi Sivaswamy, Jahnavi Sai Gamalapati, Satish Gooty Agraharam, Nagalla Balakrishna
AIM: To image the radial peripapillary capillary (RPC) network with optical coherence tomography angiography (OCTA) and measure its capillary density (CD) in the normal human retina. MATERIALS AND METHODS: Fifty-two normal participants underwent OCTA imaging with RTVue XR 100 Avanti OCT. The angioflow enface RPCs network was extracted from OCTA and 8 peripapillary sectors with a sector angle of 45 degrees were selected for quantitative analysis: superior nasal, superior temporal, temporal upper, temporal lower, nasal upper, nasal lower, inferior nasal, and inferior temporal...
November 30, 2016: Journal of Glaucoma
https://www.readbyqxmd.com/read/27897119/glaucoma-hot-topics-in-pharmacology
#19
Shiama I Balendra, Parth Arvind Shah, Mishank Jain, Andrzej Grzybowski, Maria Francesca Cordeiro
BACKGROUND: Glaucoma comprises a group of neurodegenerative diseases resulting in retinal ganglion cell death within the optic nerve head. It is projected to affect almost 80 million people worldwide by 2020. The condition's asymptomatic nature translates to over half of glaucoma sufferers being unaware of their condition. By the time of diagnosis, irreversible blindness is likely to have occurred. Prime areas of glaucoma research therefore include identification and optimization of risk factors for the disease, accurate and early diagnostic tools and novel therapeutic methods...
29, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27870778/inter-visit-test-retest-variability-of-oct-in-glaucoma
#20
John Graham Pearce, Ted Maddess
PURPOSE: To determine the inter-visit test-retest variability (TRV) of a spectral domain optical coherence tomograph, the Topcon 3D OCT-2000, in the measurement of optic nerve head topography, peripapillary retinal nerve fiber layer (pRNFL), and macular ganglion cell complex (GCC) parameters in glaucoma patients. We also examine whether TRV with this instrument varies with the extent of glaucomatous damage. METHODS: Twenty-four subjects with varying degrees of glaucoma severity provided 41 eyes with usable results for the study...
November 19, 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
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