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https://www.readbyqxmd.com/read/28806189/the-use-of-optical-coherence-tomography-in-neuro-ophthalmology
#1
Noel C Y Chan, Carmen K M Chan
PURPOSE OF REVIEW: In the last decade, with the advances of optical coherence tomography (OCT) technology, different imaging protocols and analysis algorithms have been introduced to maximize the potential of this diagnostic tool in the evaluation of different eye diseases. This review aims to provide an update on these additional features, with respect to the management of a diverse range of neuro-ophthalmologic conditions. RECENT FINDINGS: Macular ganglion cell complex (mGCC) analysis has been shown to be superior to peripapillary retinal nerve fiber layer (pRNFL) analysis in certain settings, such as differentiating Leber's hereditary optic neuropathy from functional visual loss; monitoring neurodegenerative diseases or multiple sclerosis; and predicting visual loss in nonarteritic ischemic optic neuropathy...
August 12, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28777226/is-the-optic-nerve-head-structure-impacted-by-a-diagnostic-lumbar-puncture-in-humans
#2
Muriel Poli, Philippe Denis, Eric Sellem, Ludwig-Serge Aho-Glélé, Alain M Bron
PURPOSE: To assess in vivo whether diagnostic lumbar puncture (LP) is followed by optic nerve head (ONH) and parapapillary anatomical changes in normal human eyes. METHODS: Prospective, single-center, observational case series. ONH structures (prelaminar tissue surface, anterior surface of the lamina cribrosa, central retinal vessels) and parapapillary structures (internal limiting membrane, posterior surfaces of retinal nerve fiber layer and Bruch membrane/retinal pigment epithelium complex, Bruch membrane opening, posterior surface of the choroid) were quantitatively evaluated by means of swept-source OCT (Triton Ver...
August 2, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28774935/comparing-optical-coherence-tomography-radial-and-cube-scan-patterns-for-measuring-bruch-s-membrane-opening-minimum-rim-width-bmo-mrw-in-glaucoma-and-healthy-eyes-cross-sectional-and-longitudinal-analysis
#3
Sami W Kabbara, Linda M Zangwill, Rusdeep Mundae, Naama Hammel, Christopher Bowd, Felipe A Medeiros, Robert N Weinreb, Akram Belghith
AIM: To compare the cube and radial scan patterns of the spectral domain optical coherence tomography (SD-OCT) for quantifying the Bruch's membrane opening minimum rim width (BMO-MRW). METHODS: Sixty healthy eyes and 189 glaucomatous eyes were included. The optic nerve head cube and radial pattern scans were acquired using Spectralis SD-OCT. BMO-MRWs were automatically delineated using the San Diego Automated Layer Segmentation Algorithm. The BMO-MRW diagnostic accuracy for glaucoma detection and rates of change derived from the two scan patterns were compared...
August 3, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28757693/effect-of-phacoemulsification-on-measurement-of-retinal-nerve-fiber-layer-and-optic-nerve-head-parameters-using-spectral-domain-optical-coherence-tomography
#4
Bhaskar Jha, Reetika Sharma, Murugesan Vanathi, Tushar Agarwal, Talvir Sidhu, Ankit Tomar, Tanuj Dada
PURPOSE: The purpose of this study is to determine the effect of phacoemulsification cataract extraction on measurement of retinal nerve fiber layer and optic nerve head parameters using spectral domain optical coherence tomography. MATERIAL AND METHODS: A prospective, hospital-based study of 100 patients of 40 years of age and above, with no other ocular morbidity except cataract and planned for phacoemulsification with IOL implantation (SN60WF) at a tertiary centre at AIIMS, New Delhi, India...
May 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/28750413/in-vivo-imaging-of-retinal-hypoxia-using-hypox-4-dependent-fluorescence-in-a-mouse-model-of-laser-induced-retinal-vein-occlusion-rvo
#5
Md Imam Uddin, Ashwath Jayagopal, Gary W McCollum, Rong Yang, John S Penn
Purpose: To demonstrate the utility of a novel in vivo molecular imaging probe, HYPOX-4, to detect and image retinal hypoxia in real time, in a mouse model of retinal vein occlusion (RVO). Methods: Retinal vein occlusion was achieved in adult mice by photodynamic retinal vein thrombosis (PRVT). One or two major retinal vein(s) was/were occluded in close proximity to the optic nerve head (ONH). In vivo imaging of retinal hypoxia was performed using, HYPOX-4, an imaging probe developed by our laboratory...
July 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28742840/glaucomatous-changes-in-lamina-pores-shape-within-the-lamina-cribrosa-using-wide-bandwidth-femtosecond-mode-locked-laser-oct
#6
Takuhei Shoji, Hiroto Kuroda, Masayuki Suzuki, Hisashi Ibuki, Makoto Araie, Shin Yoneya
PURPOSE: The lamina cribrosa (LC) is known to play a critical role in the pathogenesis of glaucoma. Although it has been reported that striae-shaped or slit-shaped lamina pores are more frequent in eyes with primary open angle glaucoma (POAG), this observation is based only on fundus photography. The primary object of this study is to perform layer-by-layer comparisons of the shape of lamina pores within the LC in vivo. DESIGN: Cross-sectional study. METHODS: Optic nerve head B-scans were obtained using custom-made broad-wavelength optical coherence tomography with a mode-locked laser...
2017: PloS One
https://www.readbyqxmd.com/read/28738419/posterior-staphylomas-in-pathologic-myopia-imaged-by-widefield-optical-coherence-tomography
#7
Kosei Shinohara, Noriaki Shimada, Muka Moriyama, Takeshi Yoshida, Jost B Jonas, Nagahisa Yoshimura, Kyoko Ohno-Matsui
Purpose: To examine posterior staphylomas by widefield optical coherence tomography (WF-OCT) and three-dimensional magnetic resonance imaging (3D-MRI). Methods: Highly myopic patients (myopic refractive error >8.0 diopters or axial length >26.5 mm) who had previously undergone orbital 3D-MRI were examined by WF-OCT. Results: The study included 100 eyes of 57 patients with a mean age of 67.9 ± 10.7 years (range, 44-85 years) and mean axial length of 30...
July 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28732589/accuracy-of-diagnostic-imaging-modalities-for-classifying-pediatric-eyes-as-papilledema-versus-pseudopapilledema
#8
Melinda Y Chang, Federico G Velez, Joseph L Demer, Laura Bonelli, Peter A Quiros, Anthony C Arnold, Alfredo A Sadun, Stacy L Pineles
PURPOSE: To identify the most accurate diagnostic imaging modality for classifying pediatric eyes as papilledema (PE) or pseudopapilledema (PPE). DESIGN: Prospective observational study. SUBJECTS: Nineteen children between the ages of 5 and 18 years were recruited. Five children (10 eyes) with PE, 11 children (19 eyes) with PPE owing to suspected buried optic disc drusen (ODD), and 3 children (6 eyes) with PPE owing to superficial ODD were included...
July 18, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28732047/in-vivo-analysis-of-glaucoma-related-features-within-the-optic-nerve-head-using-enhanced-depth-imaging-optical-coherence-tomography
#9
Tiago S Prata, Flavio S Lopes, Vitor G Prado, Izabela Almeida, Igor Matsubara, Syril Dorairaj, Rafael L Furlanetto, Roberto M Vessani, Augusto Paranhos
Structural differences between optic nerve head (ONH) parameters in glaucomatous and non-glaucomatous eyes has been documented, however the association between such parameters in patients with different disease stages is yet to be elucidated. We investigated the relationship between different laminar and prelaminar ONH structures using enhanced depth imaging spectral-domain optical coherence tomography (EDI OCT) in a population with and without glaucoma. In this observational case-control study, we prospectively enrolled healthy individuals and glaucomatous patients with different disease stages...
2017: PloS One
https://www.readbyqxmd.com/read/28730092/parameters-of-ocular-fundus-on-spectral-domain-optical-coherence-tomography-for-glaucoma-diagnosis
#10
REVIEW
Yu-Lin Tao, Li-Ming Tao, Zheng-Xuan Jiang, He-Ting Liu, Kun Liang, Mo-Han Li, Xuan-Sheng Zhu, Yan-Lin Ren, Bing-Jie Cui
In this review, we summarize the progression of several parameters assessed by spectral-domain optical coherence tomography (SD-OCT) in recent years for the detection of glaucoma. Monitoring the progression of defects in the retinal nerve fiber layer (RNFL) thickness is essential. Imaging and analysis of retinal ganglion cells (RGCs) and inner plexiform layer (IPL), respectively, have been of great importance. Optic nerve head (ONH) topography obtained from 3D SD-OCT images is another crucial step. Other important assessments involve locating the Bruch's membrane opening (BMO), estimating the optic disc size and rim area, and measuring the lamina cribrosa displacement...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28729947/associations-between-optic-nerve-head-related-anatomical-parameters-and-refractive-error-over-the-full-range-of-glaucoma-severity
#11
Neda Baniasadi, Mengyu Wang, Hui Wang, Mufeed Mahd, Tobias Elze
PURPOSE: To evaluate the associations between optic disc (OD)-related anatomical parameters (interartery angle [IAA] between superior and inferior temporal retinal arteries, OD tilt [TL], rotation [ROT], and torsion [TO], OD surface curvature [CUR], and central retinal vessel trunk entry point location [CRVTL] on OD) and the spherical equivalent of refractive error (SE), and to assess the impact of glaucoma severity on these relationships. METHODS: Cirrus optical coherence tomography (OCT) fundus images and 24-2 visual fields of 438 patients were included...
July 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28692595/the-quantitative-measurements-of-vascular-density-and-flow-area-of-optic-nerve-head-using-optical-coherence-tomography-angiography
#12
Fatemeh Bazvand, Reza Mirshahi, Kaveh Fadakar, Houshangh Faghihi, Siamak Sabour, Fariba Ghassemi
PURPOSE: The purpose of this study was to evaluate the vascular density (VD) and the flow area on optic nerve head (ONH) and peripapillary area, and the impact of age and sex using optical coherence tomography angiography (OCTA) in healthy human subjects. METHODS: Both eyes of each volunteer were scanned by an RTVue XR Avanti; Optovue with OCTA using the split-spectrum amplitude-decorrelation angiography algorithm technique. Masked graders evaluated enface angiodisc OCTA data...
July 7, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28663838/retinal-oximetry-in-humans-using-visible-light-optical-coherence-tomography-invited
#13
Siyu Chen, Xiao Shu, Peter L Nesper, Wenzhong Liu, Amani A Fawzi, Hao F Zhang
We measured hemoglobin oxygen saturation (sO2) in the retinal circulation in healthy humans using visible-light optical coherence tomography (vis-OCT). The measurements showed clear oxygenation differences between central retinal arteries and veins close to the optic nerve head. Spatial variations at different vascular branching levels were also revealed. In addition, we presented theoretical and experimental results to establish that noises in OCT intensity followed Rice distribution. We used this knowledge to retrieve unbiased estimation of true OCT intensity to improve the accuracy of vis-OCT oximetry, which had inherently lower signal-to-nose ratio from human eyes due to safety and comfort limitations...
March 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28660077/relationship-between-retinal-nerve-fiber-layer-thickness-and-hemoglobin-present-in-the-optic-nerve-head-in-glaucoma
#14
Marta Gonzalez-Hernandez, Jose Sigut Saavedra, Manuel Gonzalez de la Rosa
PURPOSE: To observe the relationship between topographic hemoglobin levels in the optic nerve head (ONH), the rim thickness (BMO-MRW), and retinal nerve fiber layer (RNFL) thickness. METHODS: 96 normal eyes and 82 glaucomas were examined using TOP strategy (Octopus 300 perimeter), SPECTRALIS OCT, and Laguna ONhE program which estimates hemoglobin from conventional color photographs (Horus Scope DEC 200 fundus camera). RESULTS: The correlation between Laguna ONhE glaucoma discriminant function (GDF) and SPECTRALIS BMO-MRW was R = 0...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28650590/intra-and-interobserver-reproducibility-of-bruch-s-membrane-opening-minimum-rim-width-measurements-with-spectral-domain-optical-coherence-tomography
#15
Alexandre S C Reis, Camila E S Zangalli, Ricardo Y Abe, André L Silva, Jayme R Vianna, José Paulo C Vasconcellos, Vital P Costa
PURPOSE: To investigate the reproducibility of Bruch's membrane opening minimum rim width (BMO-MRW) and retinal nerve fibre layer thickness (RNFLT) measurements using spectral domain optical coherence tomography (SD-OCT). Additionally, to investigate the reproducibility of BMO area measurements and fovea to BMO centre (FoBMO) angle. METHODS: Participants were healthy subjects (n = 30) and patients with glaucoma (n = 26). One eye of each participant was scanned to obtain optic nerve head (24 radial B-scans) and peripapillary (one circular B-scan) images by three independent examiners...
June 26, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28641680/ophthalmological-evaluation-of-integrated-resistance-and-aerobic-training-during-70-day-bed-rest
#16
Giovanni Taibbi, Ronita L Cromwell, Susana B Zanello, Patrice O Yarbough, Robert J Ploutz-Snyder, Bernard F Godley, Gianmarco Vizzeri
INTRODUCTION: We evaluated ophthalmic changes in healthy individuals who underwent integrated resistance and aerobic training (iRAT) during 70-d 6° head-down tilt (HDT) bed rest (BR). METHODS: Participants were selected using NASA standard screening procedures. Standardized NASA BR conditions were implemented. Subjects were randomly assigned to the iRAT protocol or no exercise during HDTBR. Weekly ophthalmic examinations were performed in the sitting (pre/post-BR only) and HDT (BR only) positions...
July 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28637781/detecting-optic-nerve-head-swelling-on-ultrasound-and-optical-coherence-tomography-in-children-and-young-people-an-observational-study
#17
Annegret Hella Dahlmann-Noor, Gillian W Adams, Moritz Claudius Daniel, Alison Davis, Joanne Hancox, Melanie Hingorani, Patricia Ibanez, Becky McPhee, Himanshu Patel, Marie Restori, Clare Roberts, Maria Theodorou, James Acheson
BACKGROUND: Following high-profile cases, referrals for evaluation of 'suspicious optic discs' to eye clinics in the UK have sharply increased, asking ophthalmologists to reliably distinguish between true and pseudopapilloedema. Optic nerve sheath dilatation (ONSD) on ocular ultrasound (US) is considered a reliable sign of true papilloedema, but this test is not widely available. Recently, anterior bowing of Bruch's membrane (BM) and increased retinal nerve fibre layer thickness on optical coherence tomography (OCT) have emerged as indicators of intracranial hypertension, and OCT is widely available...
June 21, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28631244/optical-coherence-tomography-angiography-in-pre-perimetric-open-angle-glaucoma
#18
Gilda Cennamo, Daniela Montorio, Nunzio Velotti, Federica Sparnelli, Michele Reibaldi, Giovanni Cennamo
PURPOSE: To evaluate the diagnostic efficacy of optical coherence tomography (OCT) angiography, in patients with pre-perimetric open-angle glaucoma. METHODS: Thirty-eight consecutive eyes of 26 patients with pre-perimetric open-angle glaucoma and 48 normal eyes of 32 controls were included in this prospective study. We evaluated OCT angiography, spectral-domain OCT and visual fields parameters. Differences between controls and patients and between OCT angiography parameters and traditional glaucoma measurements were evaluated...
June 19, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28622313/optical-coherence-tomography-analysis-of-evolution-of-bruch-s-membrane-features-in-angioid-streaks
#19
A Marchese, M Parravano, A Rabiolo, A Carnevali, E Corbelli, M V Cicinelli, M Battaglia Parodi, L Querques, F Bandello, G Querques
PurposeTo describe optical coherence tomography (OCT) features in the Bruch's membrane (BM) of eyes with angioid streaks (AS) and evaluate their evolution over the follow-up.Patients and methodsPatients with AS presenting between March 2016 and September 2016 at two tertiary referral centers were consecutively recruited in this study. Eligibility criteria included prior spectral domain (SD)-OCT images, taken at least 3 months before at the same referral center, with automated eye tracking and image alignment modules...
June 16, 2017: Eye
https://www.readbyqxmd.com/read/28611153/effects-of-short-term-mild-hypercapnia-during-head-down-tilt-on-intracranial-pressure-and-ocular-structures-in-healthy-human-subjects
#20
Steven S Laurie, Gianmarco Vizzeri, Giovanni Taibbi, Connor R Ferguson, Xiao Hu, Stuart M C Lee, Robert Ploutz-Snyder, Scott M Smith, Sara R Zwart, Michael B Stenger
Many astronauts experience ocular structural and functional changes during long-duration spaceflight, including choroidal folds, optic disc edema, globe flattening, optic nerve sheath diameter (ONSD) distension, retinal nerve fiber layer thickening, and decreased visual acuity. The leading hypothesis suggests that weightlessness-induced cephalad fluid shifts increase intracranial pressure (ICP), which contributes to the ocular structural changes, but elevated ambient CO2 levels on the International Space Station may also be a factor...
June 2017: Physiological Reports
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