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https://www.readbyqxmd.com/read/29769654/morphological-and-functional-changes-in-the-rat-retina-associated-with-2-months-of-intermittent-moderate-intraocular-pressure-elevation
#1
Bingyao Tan, Akshay Gurdita, Vivian Choh, Karen M Joos, Ratna Prasad, Kostadinka Bizheva
Morphological and functional changes in the rat retina and optic nerve head (ONH), associated with 8 weeks of intermittent moderately elevated intraocular pressure (IOP) were measured with a combined ultrahigh resolution optical coherence tomography (UHR-OCT) and electroretinography (ERG) system. The IOP of male Sprague-Dawley rats was raised in one eye to ~35 mmHg for 1 hour/day on 6 days each week using vascular loops. Single-flash ERG traces and volumetric UHR-OCT images of the ONH were acquired from both eyes before, during and after IOP elevations at weeks 1, 5 and 9 of the study...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29757019/optical-coherence-tomography-angiography-in-glaucoma-care
#2
Sunee Chansangpetch, Shan C Lin
Rapid improvements in optical coherence tomography (OCT) technology have allowed for enhancement of both image resolution and scanning speed, and the development of vascular assessment modality. Optical coherence tomography angiography (OCTA) is the non-invasive in vivo imaging of the vasculature located within the retina and optic nerve head area. The principle of OCTA is to use the variations in OCT signals caused by moving particles as the contrast mechanism for imaging of flow. Several algorithms which aim to maximize the contrast signal and minimize the noise have been developed including the phase-based techniques, intensity-based techniques (e...
May 14, 2018: Current Eye Research
https://www.readbyqxmd.com/read/29750949/automated-beta-zone-parapapillary-area-measurement-to-differentiate-between-healthy-and-glaucoma-eyes
#3
Patricia Isabel C Manalastas, Akram Belghith, Robert N Weinreb, Jost B Jonas, Min Hee Suh, Adeleh Yarmohammadi, Felipe A Medeiros, Christopher A Girkin, Jeffrey M Liebmann, Linda M Zangwill
PURPOSE: To evaluate whether automated assessment of beta-zone parapapillary atrophy (ßPPA) area can differentiate between glaucomatous and healthy eyes of varying axial lengths (AL). DESIGN: Cross-sectional study. METHODS: ßPPA was automatically identified in glaucoma and healthy eyes with enhanced depth imaging optical coherence tomography (OCT) optic nerve head (ONH) radial B-scans. Associations with AL and the presence of glaucoma were assessed...
May 8, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29750713/valsalva-maneuver-and-peripapillary-oct-angiography-vessel-density
#4
Gábor Holló
PURPOSE: To investigate the potential influence of breath holding on the results of peripapillary vessel density (VD) measurement with optical coherence tomography angiography (OCTA). METHODS: Three peripapillary VD measurements were made at 2-minute intervals on the right eye of 12 healthy young volunteers using the Angiovue/RTvue-XR OCT (software version 2017.1, Phase 7 update) without changing the head and body positions. During the first 2 measurements the volunteers were breathing normally...
May 10, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29739027/-uveitic-secondary-glaucoma
#5
Claudia Lommatzsch, Carsten Heinz
An intraocular pressure increase with development of glaucomatous damage is a common complication of uveitis. The prevalence has a wide range depending on various factors such as the underlying uveitis type and the duration of the disease. Pathogenetically, a distinction must be made between a secondary angle closure component and the more frequently occurring open-angle glaucoma. In diagnostics, in addition to the clinical optic nerve head assessment, perimetry and tonometry, the use of imaging examination equipment, such as OCT and HRT, are recommended...
May 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29721940/normative-retinal-thicknesses-in-common-animal-models-of-eye-disease-using-spectral-domain-optical-coherence-tomography
#6
Christy L Carpenter, Alice Y Kim, Amir H Kashani
Purpose This study demonstrates a standardized approach to measuring retinal thickness (RT) using spectral domain optical coherence tomography (SD-OCT) in commonly used animal models of disease and reports a normative data set for future use. Materials and Methods Twenty normal eyes of 4 adult animal models (5 rats, 5 rabbits, 5 canines, and 5 mini-pigs) were used. Manual measurements were made on the commercially available Heidelberg Spectralis™ SD-OCT to determine the total, inner, and outer retinal thickness (RT) at fixed distances from the optic nerve head (ONH) (1, 2, 3, 4, 5, and 6 mm away) in order to control for normal variation in retinal thickness...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29719642/oct-based-macular-thickness-in-a-normal-indian-pediatric-population
#7
Bharti Nigam, Pragati Garg, Lubna Ahmad, Ritika Mullick
Purpose: Cirrus optical coherence tomography (OCT) provides high resolution cross-sectional images of the retina, vitreous humor, and optic nerve head with an axial resolution of 5 μm and a reproducibility of 1.6 μm. An integrated normative database is available only for adult subjects ≥18 years of age; the normal reference ranges of the macular thicknesses of pediatric subjects are not available. The purpose of this study was to determine the normal reference range of macular thickness of pediatric...
April 2018: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/29694957/reliability-of-vessel-density-measurements-in-the-peripapillary-retina-and-correlation-with-retinal-nerve-fiber-layer-thickness-in-healthy-subjects-using-optical-coherence-tomography-angiography
#8
Xiangjun She, Jiaxian Guo, Xiaoying Liu, Hong Zhu, Tong Li, Minwen Zhou, Fenghua Wang, Xiaodong Sun
PURPOSE: To evaluate the reliability of vessel density measurements in the peripapillary retina using optical coherence tomography angiography (OCT-A) and to analyze the correlation with retinal nerve fiber layer (RNFL) thickness in healthy subjects. METHOD: Thirty-five healthy volunteers were recruited in the study. The optic disc region was scanned three times with spectral-domain OCT (SD-OCT) and split-spectrum amplitude decorrelation angiography by two skilled examiners...
April 25, 2018: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/29666920/-unusual-coloboma-of-the-optic-disc
#9
J Lenk, L E Pillunat, E Matthé
A twelve-year old girl presented herself for a routine ophthalmologic examination in our clinic. Best-corrected visual acuity (BCVA) was 1.0 on both eyes. On funduscopic examination we saw a yellow round structure inferior to the optic nerve head. In optical coherence tomography (OCT) examination the structure showed cupping and opening of the Bruch membrane and retinal pigment epithelium (RPE). Visual field testing revealed an absolute scotoma right in the area were the abnormal coloboma was localized. We diagnosed a pseudo-doubling of the optic disk, which is a rare condition with just a few reports about it in the literature...
April 17, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29659172/optic-disc-drusen-understanding-an-old-problem-from-a-new-perspective
#10
REVIEW
Steffen Hamann, Lasse Malmqvist, Fiona Costello
Optic disc drusen (ODD) are acellular deposits located in the optic nerve head of up to 2.4% of the population. They may develop as by-products of impaired axonal metabolism in genetically predisposed individuals, in whom a narrow scleral canal is hypothesized to play a role. Although ODD are often considered as benign innocent bystanders, recognized as part of a routine ophthalmological examination, the vast majority of patients with ODD have visual field defects. Optic disc drusen (ODD)-associated complications with severe visual loss, most often due to anterior ischaemic optic neuropathy, are also known to occur...
April 16, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29651339/comparison-of-optical-coherence-tomography-angiography-and-laser-speckle-flowgraphy-for-the-diagnosis-of-normal-tension-glaucoma
#11
Asuka Takeyama, Kyoko Ishida, Ayako Anraku, Masahiro Ishida, Goji Tomita
Purpose: To compare optical coherence tomography angiography (OCT-A) and laser speckle flowgraphy (LSFG) for the diagnosis of normal-tension glaucoma (NTG). Methods: Twenty-eight eyes of 28 patients with NTG and 25 eyes of 25 normal subjects matched for age, refractive errors, systemic blood pressure, and central corneal thickness were evaluated. OCT-A was used to measure whole image vessel density, inside disc vessel density, and peripapillary vessel density; using LSFG, mean blur rate (MBR) inside the whole optic nerve head (ONH) area (MBRA ), and MBR of the vessel area (MBRV ) and tissue area (MBRT ) inside the ONH, were determined...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29649006/the-influence-of-volume-and-anatomic-location-of-optic-disc-drusen-on-the-sensitivity-of-autofluorescence
#12
Frederik Cornelius Loft, Lasse Malmqvist, Anne-Sofie Wessel Lindberg, Steffen Hamann
BACKGROUND: Optic disc drusen (ODD) are acellular deposits in the optic nerve head. ODD can be diagnosed using different imaging modalities, including enhanced depth imaging optical coherence tomography (EDI-OCT) and autofluorescence (AF). It is unknown which factors determine the sensitivity of AF. The aim of this study was to investigate the effect of volume and anatomic location of ODD on the sensitivity of AF. METHODS: Cross-sectional study. RESULTS: A total of 38 patients (75 eyes) with ODD were included...
April 11, 2018: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/29627590/exploring-experimental-autoimmune-optic-neuritis-using-multimodal-imaging
#13
Praveena Manogaran, Christine Walker-Egger, Marijana Samardzija, Conny Waschkies, Christian Grimm, Markus Rudin, Sven Schippling
BACKGROUND: Neuro-axonal injury is a key contributor to non-reversible long-term disability in multiple sclerosis (MS). However, the underlying mechanisms are not yet fully understood. Visual impairment is common among MS patients, in which episodes of optic neuritis (ON) are often followed by structural retinal damage and sustained functional impairment. Alterations in the optic nerve and retina have also been described in rodent experimental autoimmune encephalomyelitis (EAE), a model of MS...
April 5, 2018: NeuroImage
https://www.readbyqxmd.com/read/29590684/-morphological-and-quantitative-changes-in-retinal-and-optic-nerve-vessels-in-experimental-glaucoma-model-with-elevated-iop-for-7-weeks
#14
Carolina Mann, Fabian Anders, Hanhan Liu, Katrin Brockhaus, Aiwei Liu, Franz H Grus, Norbert Pfeiffer, Solon Thanos, Verena Prokosch
INTRODUCTION: Glaucoma is characterised by progressive loss of retinal ganglion cells and axons. Experimental research has concentrated on understanding the pathophysiological mechanisms involved in glaucomatous damage. It is still a matter of debate whether neurons or capillaries are primarily damaged by elevated intraocular pressure (IOP). The aim of this study was to detect IOP-induced vascular changes in the vessels of the optic nerve head and the main vessels of the retina in vivo...
March 28, 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29580976/inter-eye-asymmetry-of-optical-coherence-tomography-angiography-vessel-density-in-bilateral-glaucoma-glaucoma-suspect-and-healthy-eyes
#15
Huiyuan Hou, Sasan Moghimi, Linda M Zangwill, Takuhei Shoji, Elham Ghahari, Patricia Isabel C Manalastas, Rafaella C Penteado, Robert N Weinreb
PURPOSE: To investigate inter-eye retinal vessel density asymmetry in healthy, glaucoma suspect, and mild to moderate glaucoma subjects, and its potential utility for early detection of glaucomatous damage. DESIGN: Cross-sectional study. METHODS: 153 subjects including 55 healthy, 32 glaucoma suspect, and 66 glaucoma subjects enrolled in the Diagnostic Innovations in Glaucoma Study(DIGS). Vessel density was obtained from optical coherence tomography angiography (OCT-A) macular and optic nerve head scans...
March 23, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29577172/parafoveal-and-optic-disc-vessel-density-in-patients-with-obstructive-sleep-apnea-syndrome-an-optical-coherence-tomography-angiography-study
#16
Laura Moyal, Esther Blumen-Ohana, Marc Blumen, Cybele Blatrix, Frederic Chabolle, Jean-Philippe Nordmann
AIMS: To compare optic disc perfusion, radial peripapillary capillaries (RPC) and macular vascular density, between normal subjects and subjects with obstructive sleep apnea syndrome (OSAS) using spectral-domain OCT angiography (OCTA). METHODS: Sixteen eyes of patients with mild OSAS, 17 eyes with moderate OSAS, 20 eyes with severe OSAS on polygraphy and 28 controls were evaluated with OCTA RT XR Avanti (AngioVue software, Optovue Inc., Fremont, CA). Optic nerve head (ONH), RPC and macular vessel density were measured...
March 25, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29575745/evaluation-of-two-dimensional-bruch-s-membrane-opening-minimum-rim-area-for-glaucoma-diagnostics-in-a-large-patient-cohort
#17
Philip Enders, Werner Adler, David Kiessling, Vincent Weber, Friederike Schaub, Manuel M Hermann, Thomas Dietlein, Claus Cursiefen, Ludwig M Heindl
PURPOSE: To characterize the two-dimensional parameter Bruch's membrane opening minimum rim area (BMO-MRA) in spectral domain optical coherence tomography (SD-OCT) of the optic nerve head (ONH) compared to minimum rim width (BMO-MRW) and retinal nerve fibre layer (RNFL) thickness in a large patient cohort. METHODS: Case-control, cross-sectional study of 705 eyes of 445 participants. A total of 449 eyes with glaucoma, 67 eyes with ocular hypertension and 189 healthy controls, underwent SD-OCT and confocal laser scanning tomography (CSLT), visual field testing and clinical examination...
March 24, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29563952/optic-nerve-head-parameters-measured-with-spectral-domain-optical-coherence-tomography-in-healthy-turkish-children-normal-values-repeatability-and-interocular-symmetry
#18
Ozge Yabas Kiziloglu, Okan Toygar, Baha Toygar, Ali Murat Hacimustafaoglu
To determine normal values, repeatability, and interocular symmetry of optic nerve head measurements, three spectral-domain optical coherence tomography (SD-OCT) scans were obtained from 128 healthy Turkish children aged 5-17 years consecutively and prospectively. The mean disc area, rim area, cup volume, cup to disc area ratio, and vertical and horizontal cup to disc ratios were 2.30 ± 0.42 mm2 , 1.84 ± 0.45 mm2 , 0.09 ± 0.10 mm3 , 0.20 ± 0.13, 0.37 ± 0.17, and 0.45 ± 0.20, respectively. The intraclass correlation coefficients were >0...
April 2018: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29557834/anterior-chamber-angle-tissue-as-an-incidental-optical-coherence-tomography-finding-in-a-large-healthy-caucasian-child-population
#19
José Ignacio Fernández-Vigo, Lucía De-Pablo-Gómez-de-Liaño, Bachar Kudsieh, Cristina Fernández-Vigo, José Ángel Fernández-Vigo, Julián García-Feijóo
PURPOSE: To describe the presence of anterior chamber angle (ACA) tissue as an incidental optical coherence tomography (OCT) finding in healthy children. METHODS: For this cross-sectional study, we reviewed Fourier domain OCT images obtained in 422 children as candidates for inclusion in a prior study who visited our clinic for a routine vision test. The presence of angle tissue was assessed in the nasal and temporal quadrants. On tomographies showing angle tissue, several measurements were made including ACA width and trabecular meshwork (TM) length and size...
March 19, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29550000/longitudinal-changes-of-optic-nerve-head-and-peripapillary-structure-during-childhood-myopia-progression-on-oct-boramae-myopia-cohort-study-report-1
#20
Martha Kim, Ho-Kyung Choung, Kyoung Min Lee, Sohee Oh, Seok Hwan Kim
PURPOSE: To delineate longitudinal changes in the optic nerve head (ONH) and peripapillary structure during myopia progression in childhood using spectral-domain (SD) OCT and to explore the factors associated with myopic ONH and peripapillary changes. DESIGN: Prospective cohort study. PARTICIPANTS: Twenty-three healthy children with myopia (46 eyes). METHODS: The participants underwent fundus photography, SD OCT, and axial length (AXL) measurements every 6 months for 2 years...
March 14, 2018: Ophthalmology
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