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OCT Nerve head

Kyoung Min Lee, Ho-Kyung Choung, Martha Kim, Sohee Oh, Seok Hwan Kim
PURPOSE: To investigate the positional change of central retinal vasculature and vascular trunk to deduce the change in the lamina cribrosa (LC) during axial elongation. DESIGN: Prospective cohort study. PARTICIPANTS: Twenty-three healthy myopic children (46 eyes). METHODS: Participants had undergone a full ophthalmologic examination and axial length measurement every 6 months for 2 years. Using spectral-domain OCT, circle scans centered around the optic disc in the glaucoma progression analysis mode, which enabled capturing of the same positions throughout the entire study period, and enhanced depth imaging of the deep optic nerve head complex were performed...
March 12, 2018: Ophthalmology
Kai Yu, Fei Shi, Enting Gao, Weifang Zhu, Haoyu Chen, Xinjian Chen
Optic nerve head (ONH) is a crucial region for glaucoma detection and tracking based on spectral domain optical coherence tomography (SD-OCT) images. In this region, the existence of a "hole" structure makes retinal layer segmentation and analysis very challenging. To improve retinal layer segmentation, we propose a 3D method for ONH centered SD-OCT image segmentation, which is based on a modified graph search algorithm with a shared-hole and locally adaptive constraints. With the proposed method, both the optic disc boundary and nine retinal surfaces can be accurately segmented in SD-OCT images...
March 1, 2018: Biomedical Optics Express
Hae-Young Lopilly Park, Jin Woo Kim, Chan Kee Park
OBJECTIVE: We used OCT angiography (OCT-A) to investigate parapapillary choroidal microvasculature dropout (MvD) in glaucomatous eyes with or without disc hemorrhage (DH), and the association with changes in retinal nerve fiber layer (RNFL) thickness. DESIGN: An observational case-control study. PARTICIPANTS: Eighty-two open-angle glaucoma (OAG) eyes with DH and 68 OAG eyes without DH that underwent at least 4 serial OCT examinations were included...
February 24, 2018: Ophthalmology
Andrijana Kopić, Dubravka Biuk, Josip Barać, Maja Vinković, Tvrtka Benašić, Vlatko Kopić
Over the past decade, intravitreal injections of anti-VEGF agents have been widely used and intensively developed as a treatment option for many ophthalmological indications. Due to its availability and low cost, the most frequently used anti-VEGF agent is bevacizumab. This type of therapy is often indicated in patients with exudative age-related macular degeneration (ARMD) and diabetic macular edema (DME). If, in addition to these two conditions, patients have a diagnosis of primary open angle glaucoma (POAG), they also present with optic nerve head (ONH) retinal nerve fiber layer (RNFL) thinning...
September 2017: Acta Clinica Croatica
Masoud Aghsaei Fard, Sara Okhravi, Sasan Moghimi, Prem S Subramanian
BACKGROUND: To compare macular and optic nerve head optical coherence tomography (OCT) measurements in mild to moderate papilledema and pseudopapilledema. METHODS: One hundred nineteen eyes of 61 patients with mild to moderate papilledema, 84 eyes of 48 patients with pseudopapilledema, and 60 eyes of 60 healthy normal individuals were enrolled in this cross-sectional study. Using Spectralis SD-OCT, macular scans with macular ganglion cell-inner plexiform layer (GCIPL) and macular retinal nerve fiber layer (RNFL) segmentation were performed and divided into 2 regions (inner and outer, with a diameter of 3 and 6 mm, respectively); in addition, Bruch membrane opening (BMO) area and peripapillary RNFL thickness were obtained...
February 22, 2018: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
Kaweh Mansouri, Harsha L Rao, Kirsten Hoskens, Elisa D'Alessandro, Elsa M Flores-Reyes, André Mermoud, Robert N Weinreb
PURPOSE: To investigate the diurnal variation in peripapillary and macular vessel density (VD) measurements using optical coherence tomography angiography (OCT-A) and its correlation to intraocular pressure (IOP) changes in glaucoma patients. METHODS: Prospective, observational cross-sectional study including 37 patients (74 eyes; age, 63.8±12.9▒y) with open angle glaucoma. OCT-A imaging and IOP measurements were performed at 08:00, 11:00, 14:00, and 16:00 on a single day...
February 16, 2018: Journal of Glaucoma
Marie-Claire Gaillard, Susan Houghton, Christina Stathopoulos, Francis L Munier
PURPOSE: Retinoblastoma (Rb) tumor recurrence in the papillary or macular region is a threat to life and visual prognosis respectively, making early detection indispensable. This study demonstrates the value of optical coherence tomography (OCT) in the early detection of subclinical tumor recurrence. METHODS: Since June 2012, hand-held SD-OCT (spectral domain Optical Coherence Tomography) of retro-equatorial foci, the optic head nerve and macula, is systematically performed under anesthesia in children treated and followed for Rb...
February 9, 2018: Ophthalmic Genetics
Patrycja Krzyżanowska-Berkowska, Aleksandra Melińska, Iwona Helemejko, D Robert Iskander
PURPOSE: The purpose of the study is to assess the displacement of lamina cribrosa (LC) and prelaminar tissue area (PTA) changes following trabeculectomy and non-penetrating deep sclerectomy (NPDS) using spectral-domain optical coherence tomography (SD-OCT) with enhanced depth imaging technology. METHODS: A total of 30 patients underwent glaucoma surgery. Sixteen patients underwent trabeculectomy, and 14 patients undertook NPDS. Serial horizontal B-scan images of optic nerve head (ONH) were obtained using SD-OCT preoperatively, and at 2-week, 1-, 3-, and 6-month postoperative visit (6 pv)...
February 8, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Mi Sun Sung, Tae Hee Lee, Hwan Heo, Sang Woo Park
PURPOSE: To evaluate the retinal microvasculature of peripapillary and macular regions in highly myopic eyes and investigate the association between the vascular parameters and optic nerve head (ONH) deformation. DESIGN: Cross-sectional study METHODS: Seventy-one subjects with highly myopic eyes and 26 subjects with emmetropic eyes were included. Horizontal B-scan images of the ONH were obtained using optical coherence tomography (OCT) and horizontal tilt angles were measured...
February 5, 2018: American Journal of Ophthalmology
Fabio Lavinsky, Camila Zanella Benfica, Nédio Castoldi, Anne Elise Cruz do Carmo Chaves, Paulo Augusto de Arruda Mello
Purpose: To evaluate the hypotenuse of the vertical optic nerve head cup (HVOC), measured using the length and depth of the cup obtained with enhanced depth imaging spectral-domain optic coherence tomography (SD-OCT), as a biomarker for glaucoma diagnosis. Methods: This was a prospective cross-sectional study of patients with glaucoma and controls. SD-OCT was performed in all participants to assess average circumpapillary retinal nerve fiber layer (RNFL) thickness...
2018: Clinical Ophthalmology
Nimesh Patel, Faith McAllister, Laura Pardon, Ronald Harwerth
Intraocular pressure (IOP) is an important risk factor for glaucoma, and the response of the ONH and surrounding tissues to elevated IOP are often investigated to better understand pathophysiology. In vivo structure including that of the optic nerve head (ONH) and surrounding tissue of the eye are often assessed using optical coherence tomography (OCT). With advances in OCT technology, both large vessels and capillaries can be imaged non-invasively (OCT Angiography). Because a significant portion of retinal thickness is comprised of vasculature, the purpose of the current study was to investigate OCT structural and vascular changes in healthy non-human primate eyes with systematic graded increases and decreases in IOP...
February 1, 2018: Experimental Eye Research
Sunee Chansangpetch, Guofu Huang, Paul Coh, Catherine Oldenburg, Behzad Amoozgar, Mingguang He, Shan C Lin
PURPOSE: To compare optic nerve head (ONH), peripapillary retinal nerve fiber layer (pRNFL) and ganglion cell complex (GCC) parameters between Caucasian and ethnic Chinese. METHODS: Normal subjects greater than 40 years old and self-identified as being Caucasian and Chinese were recruited. They were evaluated with spectral-domain optical coherence tomography (OCT) (RTVue-100, Optovue, Fremont, CA). Parameters related to the ONH, pRNFL and GCC analysis protocols were acquired...
February 1, 2018: Journal of Glaucoma
Xiaoyu Xu, Hui Xiao, Xinxing Guo, Xiangxi Chen, Linlin Hao, Jingyi Luo, Xing Liu
The purpose is to assess the diagnostic ability for early glaucoma of macular ganglion cell-inner plexiform layer (GCIPL) thickness in a Chinese population including glaucoma suspects.A total of 367 eyes with primary open-angle glaucoma (168 early glaucoma, 78 moderate glaucoma, and 121 advanced glaucoma), 52 eyes with ocular hypertension (OHT), 59 eyes with enlarged cup-to-disc ratio (C/D), and 225 normal eyes were included. GCIPL thickness (average, minimum, superotemporal, superior, superonasal, inferonasal, inferior, and inferotemporal), retinal nerve fiber layer (RNFL) thickness, and optic nerve head (ONH) parameters were measured using Cirrus high-definition optical coherence tomography (OCT) and compared...
December 2017: Medicine (Baltimore)
P Enders, F Schaub, W Adler, M M Hermann, T S Dietlein, C Cursiefen, L M Heindl
PurposeTo compare Bruch's membrane opening (BMO)-based spectral domain optical coherence tomography (SD-OCT) and margin based confocal scanning laser tomography (CSLT) of the optic nerve head (ONH) to visual field function in large optic discs (macrodiscs) and to assess performance for glaucoma detection.MethodsIn a case-control, cross-sectional study, 125 eyes of 125 patients with disc size >2.45 mm2 , thereof 44 glaucoma and 11 ocular hypertension (OHT) patients and 70 healthy controls underwent SD-OCT and CSLT examination, visual field testing and clinical evaluation...
February 2018: Eye
Natalia Ivanovna Kurysheva, Vitaliy Nikiforovich Shlapak, Tamara Yakovlevna Ryabova
Primary vascular dysregulation (PVD) is believed to be a main cause of local vasospasm and impaired autoregulation as a possible contributing factor in the pathogenesis of normal tension glaucoma (NTG). Subjects with PVD respond stronger to psychological stress. Autonomic dysfunction is another reason of instable ocular blood flow and may be studied by means of assessment of heart rate variability (HRV) especially during a hand-cold provocation test (CPT).To compare the shift of HRV parameters in NTG and healthy subjects after a cold provocation test and to assess the relation between structural damage, circulatory parameters and autonomic dysfunction in NTG...
February 2018: Medicine (Baltimore)
Patrick A Sibony, Junchao Wei, Ian A Sigal
PURPOSE: To determine if ocular ductions deform intrapapillary and peripapillary tissues in optic nerve head drusen (ONHD) and to compare these deformations with healthy eyes and eyes with other optic neuropathies. DESIGN: Observational case series. PARTICIPANTS: Twenty patients with ONHD. METHODS: Axial rasters of the optic nerve from a spectral-domain OCT device (Cirrus 5000; Carl Zeiss Meditec, Inc, Dublin, CA) were used to analyze the shape of the peripapillary basement membrane (ppBM) layer in 20 confirmed cases of ONHD...
January 17, 2018: Ophthalmology
Mengyu Wang, Qingying Jin, Hui Wang, Dian Li, Neda Baniasadi, Tobias Elze
Purpose: We quantified the interrelationship between retinal blood vessel (BV) anatomical variation, spherical equivalent (SE) of refractive error, and functional diagnostic parameters in glaucoma to identify optimal parameters for the improvement of optical coherence tomography (OCT) retinal nerve fiber layer thickness (RNFLT) norms. Methods: A trained observer marked the intersections of the main superior/inferior temporal arteries and veins with concentric circles around the optic nerve head (ONH) center on fundus images...
January 2018: Translational Vision Science & Technology
Michael Yapp, George Rennie, Michael P Hennessy, Michael Kalloniatis, Barbara Zangerl
PURPOSE: Optic nerve head (ONH) assessment and its interpretation in healthy patients and those with glaucoma remains a pivotal topic specifically considering rapid advancements in imaging technologies. We undertook a large-scale, mixed cohort, comparative study to assess the correlation of optic disc measurements between different imaging modalities and investigated the impact of patient and disc associated parameters. METHODS: ONH sizes were obtained from one randomly selected eye of each of 209 patients using stereophotography, confocal scanning laser ophthalmoscopy and two different optical coherence tomographers (OCT)...
2018: PloS One
Meghna R Beotra, Xiaofei Wang, Tin A Tun, Liang Zhang, Mani Baskaran, Tin Aung, Nicholas G Strouthidis, Michaël J A Girard
Purpose: To compare in vivo lamina cribrosa (LC) strains (deformations) following acute IOP elevation in healthy, glaucoma, and ocular hypertensive subjects. Methods: There were 20 healthy, 20 high-tension primary open-angle glaucoma (POAG), 16 primary angle-closure glaucoma (PACG), and 20 ocular hypertensive (OHT; with normal visual fields) eyes studied. For each test eye, the optic nerve head was imaged three times (at baseline IOP, following an acute elevation of IOP to approximately 35 then 45 mm Hg using an ophthalmodynamomter) using optical coherence tomography (OCT)...
January 1, 2018: Investigative Ophthalmology & Visual Science
Maged Alnawaiseh, Larissa Lahme, Viktoria Müller, André Rosentreter, Nicole Eter
PURPOSE: To evaluate the correlation between flow density, as measured by optical coherence tomography angiography (OCTA), and structural and functional parameters in patients with open-angle glaucoma. METHODS: Thirty-four eyes of 34 patients with open-angle glaucoma and 35 eyes of 35 healthy subjects were prospectively included in this study. OCTA was performed using RTVue XR Avanti with AngioVue. The macula was imaged with a 3 × 3 mm scan and the optic nerve head (ONH) with a 4...
January 13, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
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