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https://www.readbyqxmd.com/read/28426715/acute-hypoxia-influences-collagen-and-matrix-metalloproteinase-expression-by-human-keratoconus-cells-in-vitro
#1
Tina B McKay, Jesper Hjortdal, Shrestha Priyadarsini, Dimitrios Karamichos
Keratoconus (KC) is a progressive corneal ectasia linked to thinning of the central cornea. Hard contact lenses, rigid gas permeable lenses, and scleral lenses are the primary treatment modalities for early to mid- stages of KC to correct refractive error and astigmatism that develops as a result of an irregular corneal structure. These treatments are associated with significant drawbacks, including reduced availability of the tear film and oxygen to the corneal epithelium and stroma. However, it remains unknown whether hypoxia affects corneal integrity in the KC pathobiology...
2017: PloS One
https://www.readbyqxmd.com/read/28410728/corneal-collagen-crosslinking-and-pigment-dispersion-syndrome
#2
Benjamin R LaHood, Sacha Moore
We describe the case of a keratoconus patient with pigment dispersion syndrome (PDS) who was treated for progressive corneal ectasia with corneal collagen crosslinking (CXL). Pigment dispersion syndrome has been shown to have associated morphologic changes of the corneal endothelium. Corneal CXL has the potential to cause toxicity to the corneal endothelium, and adjacent pigment might increase the likelihood of damage. In this case, the presence of PDS had no detrimental effect on the outcome of treatment, and no complications were observed at 12 months follow-up, indicating that it may be safe to perform corneal CXL in the setting of PDS...
March 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28407827/-values-of-neutrophil-lymphocyte-ratio-and-platelet-lymphocyte-ratio-in-predicting-sensitivity-to-intravenous-immunoglobulin-in-kawasaki-disease
#3
Ying-Di Yuan, Jun Sun, Peng-Fei Li, Chun-Lei Wei, Yan-Hui Yu
OBJECTIVE: To study the values of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in predicting the sensitivity to intravenous immunoglobulin (IVIG) in Kawasaki disease (KD). METHODS: A retrospective cohort study was conducted in 404 children with newly diagnosed KD. The data on routine blood tests, NLR, and PLR were collected before and after IVIG treatment. The receiver operating characteristic (ROC) curve was used to determine the cut-off values of NLR and PLR in predicting the insensitivity to IVIG...
April 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28399067/role-of-the-corneal-epithelium-measurements-in-keratorefractive-surgery
#4
Marcella Q Salomão, Ana Luisa Hofling-Lima, Bernardo T Lopes, Ana Laura C Canedo, Daniel G Dawson, Rui Carneiro-Freitas, Renato Ambrósio
PURPOSE OF REVIEW: Refractive surgery has stimulated considerable progress in corneal and anterior segment imaging, and optical characterization of the eye. From front surface corneal topography, we evolved to three-dimensional corneal tomography with limbus to limbus characterization of the front and back corneal surfaces and pachymetric mapping. Corneal anatomical evaluation has further evolved to layered or segmental tomography with the ability to characterize corneal epithelial thickness profile and the elevation of stromal front surface...
April 8, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28382079/the-relationship-between-vitamin-d-and-coronary-artery-ectasia-in-subjects-with-a-normal-c-reactive-protein-level
#5
Goksel Cagirci, Selcuk Kucukseymen, Isa Oner Yuksel, Nermin Bayar, Erkan Koklu, Ramazan Guven, Sakir Arslan
BACKGROUND AND OBJECTIVES: Vitamin D is generally known to be closely related to inflammation. The effects of vitamin D on coronary artery disease (CAD) are not fully explained. Nowadays, coronary artery ectasia (CAE) cases are common and are regarded as being a kind of CAD. We aimed to investigate, in a case-control study, the relationship between vitamin D and CAE without an associated inflammatory process. SUBJECTS AND METHODS: This study population included 201 patients (CAE group, 121 males; mean age, 61...
March 2017: Korean Circulation Journal
https://www.readbyqxmd.com/read/28379654/corneal-collagen-crosslinking-for-post-lasik-ectasia-an-australian-study
#6
Jessica Y Tong, Deepa Viswanathan, Christopher Hodge, Gerard Sutton, Colin Chan, John J Males
PURPOSE: Post laser-assisted in situ keratomileusis (LASIK) ectasia is a rare and unpredictable complication after LASIK. Corneal collagen crosslinking (CXL) has emerged as a promising technique to address this complication. Our study evaluates the long-term efficacy of CXL for post-LASIK ectasia in an Australian setting. DESIGN: Retrospective review of post-LASIK ectasia patients referred to and treated at 3 corneal refractive surgery institutions in Sydney, Australia...
March 29, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28378434/presentation-of-missed-childhood-kawasaki-disease-in-adults-experience-from-a-tertiary-care-center-in-north-india
#7
Rajesh Vijayvergiya, Sagar Bhattad, Subhash Varma, Manphool Singhal, John Gordon, Surjit Singh
AIM: Kawasaki disease (KD) is the most common cause of acquired heart disease in children in Japan, North America and Europe. Undiagnosed and untreated KD can have clinically significant consequences later in life. The clinical spectrum of missed childhood KD is frequently being recognized during adulthood. We report four adult cases of acute coronary events, in which coronary angiography was suggestive of sequelae of KD. METHODS: Four adults who presented with acute coronary events, had coronary angiography for evaluation...
April 5, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28367587/radiofrequency-ablation-for-gastric-antral-vascular-ectasia-and-radiation-proctitis
#8
Pave Markos, Branko Bilic, Hrvoje Ivekovic, Nadan Rustemovic
Gastric antral vascular ectasia (GAVE) and chronic radiation proctitis (CRP) are well-known causes of repeated gastrointestinal bleeding and iron deficiency anemia. Argon plasma coagulation (APC) is the most common endoscopic therapy used, but some patients need multiple APC sessions. Radiofrequency ablation (RFA) is recently used in GAVE and CRP treatment with promising results. In this case series, we analyzed data for 15 patients with GAVE and 5 patients with CRP that had multiple prior APC treatment. They were treated with RFA HALO 90 catheter (HALO90 Ablation Catheter System; Covidien, GI Solutions, Sunnyvale, CA) in our tertiary referral center...
April 3, 2017: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/28366677/change-in-vault-during-scleral-lens-trials-assessed-with-anterior-segment-optical-coherence-tomography
#9
Varsha M Rathi, Preeji S Mandathara, Srikanth Dumpati, Virender S Sangwan
PURPOSE: To assess the change in vault during scleral lens fitting with anterior segment optical coherence tomography (AS-OCT). METHODS: This study comprised of patients who had AS-OCT performed after 1h and 4h of scleral lens wear (PROSE, prosthetic replacement of the ocular surface ecosystem, Boston Foundation for Sight, Needham Heights, MA, USA). Vault was measured on AS-OCT as the distance between the front surface of the cornea in the center and the back surface of the scleral lens...
March 30, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28359622/-corneal-ectasia-complicating-a-lime-burn
#10
O R Matsanga, O Lezrek, N Boutimzine, A Jait, A K Ntoutoume Rolande, M Laghmari, O Cherkaoui
No abstract text is available yet for this article.
April 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28355171/glaucoma-mini-shunt-implantation-after-keratoplasty
#11
Jasbeth Ledesma-Gil, María de Los Ángeles García-Rodríguez, Lulu U Gurria, Enrique O Graue-Hernández, Alejandro Navas
PURPOSE: To report the outcomes of patients who underwent miniature glaucoma shunt implantation after secondary glaucoma due to keratoplasty. MATERIALS AND METHODS: Prospective study of consecutive clinical cases who underwent mini-glaucoma shunt implantation following keratoplasty. In brief, a fornix-based conjunctival flap was performed, approximately 50% thickness scleral flap. Mitomycin C 0.025% placed under Tenon's capsule. A 25-G needle created entry for mini-shunt...
April 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28350559/interventional-spine-considerations-for-dural-ectasia-in-a-patient-with-marfan-syndrome
#12
David J Kohns
For patients with Marfan syndrome who present with radicular low back pain, interventional spine providers should be familiar with dural ectasia with variable diffuse thinning of the posterior wall of the lumbar spine and sacrum. Providers should carefully weigh the risks and benefits of offering elective procedures because altered anatomy may put these patients at higher risk of dural puncture. Patient selection is essential because hydrostatic pressures and/or neural tension should also be considered as potential pain generators that may not be relieved by steroid injections...
March 27, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28349371/intraoral-salivary-duct-cyst-clinical-and-histopathologic-features-of-177-cases
#13
Ivan J Stojanov, Umer A Malik, Sook-Bin Woo
The salivary duct cyst (SDC) is a reactive ductal ectasia most frequently seen in major salivary glands, and likely caused by obstruction. The aim of this study is to define the clinical and histopathologic spectrum of intraoral SDCs. Cases were retrieved from the archives of Harvard School of Dental Medicine/StrataDx, Inc. from January 2012 to August 2014. There were 177 cases of which 103 (58.2%) occurred in females, with a median age of 56 (range 2-95). Approximately half of cases (45.8%) presented in the area of the buccal mucosa, lower lip mucosa, or mandibular vestibule, and 23...
March 27, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28331753/retrospective-analysis-of-women-with-only-mastalgia
#14
Mehmet Arslan, Halime Seda Küçükerdem, Hüseyin Can, Ercüment Tarcan
OBJECTIVE: Mastalgia is the most common symptom in women, who has gone under breast imaging. 70% of women face with mastalgia at least once in their lifetime. In our study, we aimed to investigate the examinations and the results of the females referred to our outpatient clinics with mastalgia and to determine the frequency of malignancy. MATERIALS AND METHODS: Files of all women patients referred to General Surgery Outpatient Clinics between 01.06.2014-31.05.2015 has been investigated retrospectively...
October 2016: Journal of Breast Health (2013)
https://www.readbyqxmd.com/read/28328595/hemorrhage-and-infarction-of-the-conjunctiva-and-orbit-in-essential-thrombocythemia
#15
Jaehoon Na, Soo Youn Choi, Sehyun Baek, Hwa Lee
An 82-year-old woman who had a history of essential thrombocythemia presented with ocular pain, bleeding, and decreased visual acuity of the left eye. Orbital computed tomography revealed a relatively well-defined homogenous mass-like lesion in the left subconjunctival and intraconal space. Conjunctival biopsy showed acute inflammation with necrosis, vascular ectasia with thrombosis and hemorrhage. After the treatment with hydroxyurea and anagrelide, her symptom and lesion were markedly improved. Hematologic disorders like essential thrombocythemia should be considered in patients with severe spontaneous bleeding around the eye...
March 21, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28327939/a-new-classification-for-pathologies-of-spinal-meninges-part-1-dural-cysts-dissections-and-ectasias
#16
Jörg Klekamp
BACKGROUND: The clinical significance of pathologies of the spinal dura is often unclear and their management controversial. OBJECTIVE: To classify spinal dural pathologies analogous to vascular aneurysms, present their symptoms and surgical results. METHODS: Among 1519 patients with spinal space-occupying lesions, 66 patients demonstrated dural pathologies. Neuroradiological and surgical features were reviewed and clinical data analyzed. RESULTS: Saccular dural diverticula (type I, n = 28) caused by defects of both dural layers, dissections between dural layers (type II, n = 29) due to defects of the inner layer, and dural ectasias (type III, n = 9) related to structural changes of the dura were distinguished...
March 17, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28322100/could-neutrophil-lymphocyte-ratio-be-an-indicator-of-coronary-artery-disease-coronary-artery-ectasia-and-coronary-slow-flow
#17
Mücahid Yılmaz, Hasan Korkmaz, Mehmet Nail Bilen, Ökkeş Uku, Ertuğrul Kurtoğlu
Objective To determine whether neutrophil/lymphocyte ratio (NLR) differed between patients with isolated coronary artery disease (CAD), isolated coronary artery ectasia (CAE), coronary slow flow and normal coronary anatomy. Methods Patients who underwent coronary angiography were consecutively enrolled into one of four groups: CAD, coronary slow flow, CAE and normal coronary anatomy. Results The CAD ( n = 40), coronary slow flow ( n = 40), and CAE ( n = 40) groups had similar NLRs (2.51 ± 0...
December 2016: Journal of International Medical Research
https://www.readbyqxmd.com/read/28317679/distinguishing-between-contact-lens-warpage-and-ectasia-usefulness-of-optical-coherence-tomography-epithelial-thickness%C3%A2-mapping
#18
Julie M Schallhorn, Maolong Tang, Yan Li, Derek J Louie, Winston Chamberlain, David Huang
PURPOSE: To distinguish between corneal ectasia and contact lens-related warpage by characteristic patterns on corneal topography and optical coherence tomography (OCT) epithelial thickness maps. SETTING: Casey Eye Institute, Portland, Oregon, USA. DESIGN: Prospective and retrospective case series. METHODS: Axial and mean power maps were obtained on corneal topography systems. Epithelial thickness maps were generated using RTVue OCT...
January 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28317666/transepithelial-crosslinking-retreatment-of-progressive-corneal-ectasia-unresponsive-to-classic-crosslinking
#19
Roy S Rubinfeld, Rachel H Epstein, Parag A Majmudar, Deborah Kim, Michael Choi, Randy J Epstein
A 41-year-old man presented 10 years after uneventful laser in situ keratomileusis (LASIK) with symptomatic post-LASIK ectasia. He had treatment with the classic Dresden epithelium-off technique and presented 4 years later with progression of the ectasia. He was subsequently retreated with conductive keratoplasty (CK) followed by a new proprietary epithelium-on corneal collagen crosslinking (CXL) procedure using a proprietary transepithelial riboflavin formulation and delivery system on the following day...
January 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28315339/elastic-microfibril-distribution-in-the-cornea-differences-between-normal-and-keratoconic-stroma
#20
Tomas L White, Philip N Lewis, Robert D Young, Koji Kitazawa, Tsutomu Inatomi, Shigeru Kinoshita, Keith M Meek
The optical and biomechanical properties of the cornea are largely governed by the collagen-rich stroma, a layer that represents approximately 90% of the total thickness. Within the stroma, the specific arrangement of superimposed lamellae provides the tissue with tensile strength, whilst the spatial arrangement of individual collagen fibrils within the lamellae confers transparency. In keratoconus, this precise stromal arrangement is lost, resulting in ectasia and visual impairment. In the normal cornea, we previously characterised the three-dimensional arrangement of an elastic fiber network spanning the posterior stroma from limbus-to-limbus...
March 14, 2017: Experimental Eye Research
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