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Surface ablation

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https://www.readbyqxmd.com/read/28441823/-evaluation-of-a-low-dose-imaging-protocol-on-radiation-exposure-reduction-in-pediatric-supraventricular-tachycardia-ablation-procedure
#1
F Wang, Y Lu, C Yuan, J R Bai, H S Yang, L Wu
Objective: To evaluate the feasibility and efficiency of a low dose imaging protocol on reducing X-ray dose level in pediatric supraventricular tachycardia (SVT) ablation procedure. Method: Data were collected from 103 patients who underwent catheter ablation for SVT in Children's Hospital of Fudan University from January 2014 to October 2016 in terms of body weight, body surface area (BSA), SVT types, accessory pathway location, fluoroscopy time and the radiation dose (including AIR KERMA and dose area product) in a case observational study...
April 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28441214/the-osteo-odonto-keratoprosthesis
#2
Mehran Zarei-Ghanavati, Venkata Avadhanam, Alfonso Vasquez Perez, Christopher Liu
PURPOSE OF REVIEW: To describe the practice of and recent developments in the osteo-odonto-keratoprosthesis. RECENT FINDINGS: Formal psychological assessment and support have been described. A sub-aqua system for fashioning the osteo-odonto-keratoprosthesis lamina; adoption of thicker laminae; use of bisphosphonate drugs; advances in laminar imaging; and use of bone augmentation and bone morphogenetic protein have been described for prevention, detection, and management of laminar resorption...
April 24, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28435216/pain-perception-description-after-advanced-surface-ablation
#3
Eva M Sobas, Sebastián Videla, Amanda Vázquez, Itziar Fernández, Miguel J Maldonado, José-Carlos Pastor
PURPOSE: The objective of this study was to characterize the evolution of ocular pain after advanced surface ablation (ASA) to improve strategies in postoperative pain management. METHODS: This was a multicenter, prospective, descriptive, cohort study. The inclusion criteria were healthy individuals ≥18 years old receiving bilateral alcohol-assisted surface ablation with epithelial removal. Pain intensity was evaluated with the visual analog scale (VAS) and the numeric pain rating scale before and after surgery...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28434449/electrical-superior-vena-cava-isolation-using-a-novel-pace-and-ablate-technique-under-diaphragmatic-electromyography-monitoring
#4
Shinsuke Miyazaki, Shigeki Kusa, Hitoshi Hachiya, Hiroshi Taniguchi, Takayuki Niida, Sadamitsu Ichijo, Kenzo Hirao, Yoshito Iesaka
BACKGROUND: Diaphragmatic compound motor action potential (CMAP) amplitude monitoring is a standard technique to anticipate phrenic nerve injury during cryoballoon ablation. OBJECTIVE: The purpose of this study was to evaluate the feasibility of a novel superior vena cava isolation (SVCI) technique using simultaneous pacing and ablation through the tip of a single mapping/ablation catheter. METHODS: Fifty-four patients with atrial fibrillation were included...
May 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28424266/disease-associated-extracellular-loop-mutations-in-the-adhesion-g-protein-coupled-receptor-g1-adgrg1-gpr56-differentially-regulate-downstream-signaling
#5
Ayush Kishore, Randy A Hall
Mutations to the adhesion G protein-coupled receptor ADGRG1 (G1; also known as GPR56) underlie the neurological disorder bilateral frontoparietal polymicrogyria (BFPP). Disease-associated mutations in G1 studied to date are believed to induce complete loss of receptor function, either through disruption of receptor trafficking or signaling activity. Given that N-terminal truncation of G1 and other adhesion G protein-coupled receptors has been shown to significantly increase the receptors' constitutive signaling, we examined two different BFPP-inducing extracellular loop mutations (R565W and L640R) in the context of both full-length and N-terminally truncated (deltaNT) G1...
April 19, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28422479/on-demand-gas-to-liquid-process-to-fabricate-thermoresponsive-antimicrobial-nanocomposites-and-coatings
#6
Bijay Kumar Poudel, Jae Hong Park, Jeong Hoon Byeon
Antimicrobial material is emerging as a major component of the mitigation strategy against microbial growth on abiotic surfaces. In this work, a newly designed process is proposed to fabricate thermoresponsive antimicrobial nanocomposites (TANs) and coatings (TACs) as an on-demand system. Thermoresponsive polymer (TRP)-incorporated silver (Ag) nanocomposites with silica nanoparticles (SNPs) or carbon nanotubes (CNTs; Ag-SNP@TRP or Ag-CNT@TRP) were produced by a single-pass gas-to-liquid process. The SNPs or CNTs were first produced by spark ablation and successively injected for dispersal in a liquid cell containing polydimethylsiloxane, poly(N-isopropylacrylamide), and silver nitrate under ultrasound irradiation...
April 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28415208/x-ray-shadow-imprint-of-hydrodynamic-instabilities-on-the-surface-of-inertial-confinement-fusion-capsules-by-the-fuel-fill-tube
#7
A G MacPhee, D T Casey, D S Clark, S Felker, J E Field, S W Haan, B A Hammel, J Kroll, O L Landen, D A Martinez, P Michel, J Milovich, A Moore, A Nikroo, N Rice, H F Robey, V A Smalyuk, M Stadermann, C R Weber
Measurements of hydrodynamic instability growth for a high-density carbon ablator for indirectly driven inertial confinement fusion implosions on the National Ignition Facility are reported. We observe significant unexpected features on the capsule surface created by shadows of the capsule fill tube, as illuminated by laser-irradiated x-ray spots on the hohlraum wall. These shadows increase the spatial size and shape of the fill tube perturbation in a way that can significantly degrade performance in layered implosions compared to previous expectations...
March 2017: Physical Review. E
https://www.readbyqxmd.com/read/28411450/activatable-near-infrared-dye-conjugated-hyaluronic-acid-based-nanoparticles-as-a-targeted-theranostic-agent-for-enhanced-fluorescence-ct-photoacoustic-imaging-guided-photothermal-therapy
#8
Xiaolong Liang, Lei Fang, Xiaoda Li, Xu Zhang, Fan Wang
Targeted theranostic nano-system integrating functions of both diagnosis and therapy shows great potential for improving diagnosis and therapeutic efficacy. Herein, multifunctional nanoparticle based on activatable hyaluronic acid (HA) conjugating two near-infrared (NIR) dyes of Cy5.5 and IR825 was successfully designed and fabricated, and simultaneously used as a carrier for encapsulating perfluorooctylbromide (PFOB). In this system, PFOB showed good capability to absorb the X-rays, Cy5.5 on the outer surface acted as a fluorescent dye activatable by hyaluronidases (Hyals) in the tumor, and IR825 in the core as a photothermal agent...
July 2017: Biomaterials
https://www.readbyqxmd.com/read/28405494/overcoming-resistance-to-her2-targeted-therapy-with-a-novel-her2-cd3-bispecific-antibody
#9
Andres Lopez-Albaitero, Hong Xu, Hongfen Guo, Linlin Wang, Zhihao Wu, Hoa Tran, Sarat Chandarlapaty, Maurizio Scaltriti, Yelena Janjigian, Elisa de Stanchina, Nai-Kong V Cheung
T-cell-based therapies have emerged as one of the most clinically effective ways to target solid and non-solid tumors. HER2 is responsible for the oncogenesis and treatment resistance of several human solid tumors. As a member of the HER family of tyrosine kinase receptors, its over-activity confers unfavorable clinical outcome. Targeted therapies directed at this receptor have achieved responses, although development of resistance is common. We explored a novel HER2/CD3 bispecific antibody (HER2-BsAb) platform that while preserving the anti-proliferative effects of trastuzumab, it recruits and activates non-specific circulating T-cells, promoting T cell tumor infiltration and ablating HER2(+) tumors, even when these are resistant to standard HER2-targeted therapies...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28403523/autologous-cell-suspension-grafting-in-segmental-vitiligo-and-piebaldism-a-randomised-controlled-trial-comparing-full-surface-and-fractional-co2-laser-recipient-site-preparations
#10
J E Lommerts, A A Meesters, L Komen, M W Bekkenk, M A de Rie, R M Luiten, A Wolkerstorfer
BACKGROUND: Autologous non-cultured cell suspension transplantation is an effective treatment for repigmentation in segmental vitiligo and piebaldism. Full surface laser ablation is frequently used to prepare the recipient site before cell suspension transplantation, even though optimal laser settings and ablation depth are unknown. OBJECTIVES: To assess the efficacy and safety of less invasive recipient site preparations. METHODS: In a randomised, observer-blinded, controlled trial we compared different recipient site preparations before cell suspension transplantation in segmental vitiligo and piebaldism...
April 12, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28401348/ultrapulsed-fractional-ablative-carbon-dioxide-laser-treatment-of-hypertrophic-burn-scars-evaluation-of-an-in-patient-controlled-standardized-treatment-approach
#11
Julian Poetschke, Ulf Dornseifer, Matteo Tretti Clementoni, Markus Reinholz, Hannah Schwaiger, Stephanie Steckmeier, Thomas Ruzicka, Gerd G Gauglitz
In this study, we aimed to quantify the effects of fractional ablative carbon dioxide laser therapy in the treatment of widespread hypertrophic burn scars. While many different pilot studies have described the potential of the technology and expert groups and current guidelines, alike, recommend its use, the level of evidence for the efficacy of fractional CO2-laser treatment for burn scars is currently very low. Ten patients (three male, seven female) with hypertrophic burn scars were treated with a single course of fractional CO2-laser therapy in an in-patient controlled setup, using a standardized treatment paradigm...
April 12, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28401265/dynamic-contrast-enhanced-mr-imaging-in-osteoid-osteoma-relationships-with-clinical-and-ct-characteristics
#12
P Pottecher, E Sibileau, S Aho, B Hamze, C Parlier, J D Laredo, V Bousson
OBJECTIVE: To correlate dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) features to clinical and computed tomography (CT) morphological features of osteoid osteoma (OO). MATERIALS AND METHODS: Our institutional review board approved this retrospective study, waiving the need for informed consent. We included the 102 patients treated with interstitial laser ablation for histologically documented OO at our institution in 2008-2013. DCE-MRI variables were the time-enhancement pattern and rising slope (Sloperise) and CT variables were the bone and segment involved (OObone and OOsegment, respectively), OO location relative to the native cortex (OOcortex), nidus surface area, vessel sign, and largest neighboring-vessel diameter (Dmaxvessel)...
April 11, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28399408/eradication-of-tumors-through-simultaneous-ablation-of-cd276-b7-h3-positive-tumor-cells-and-tumor-vasculature
#13
Steven Seaman, Zhongyu Zhu, Saurabh Saha, Xiaoyan M Zhang, Mi Young Yang, Mary Beth Hilton, Karen Morris, Christopher Szot, Holly Morris, Deborah A Swing, Lino Tessarollo, Sean W Smith, Sylvia Degrado, Dmitry Borkin, Nareshkumar Jain, Julia Scheiermann, Yang Feng, Yanping Wang, Jinyu Li, Dean Welsch, Gary DeCrescenzo, Amit Chaudhary, Enrique Zudaire, Kimberly D Klarmann, Jonathan R Keller, Dimiter S Dimitrov, Brad St Croix
Targeting the tumor vasculature with antibody-drug conjugates (ADCs) is a promising anti-cancer strategy that in order to be realized must overcome several obstacles, including identification of suitable targets and optimal warheads. Here, we demonstrate that the cell-surface protein CD276/B7-H3 is broadly overexpressed by multiple tumor types on both cancer cells and tumor-infiltrating blood vessels, making it a potentially ideal dual-compartment therapeutic target. In preclinical studies CD276 ADCs armed with a conventional MMAE warhead destroyed CD276-positive cancer cells, but were ineffective against tumor vasculature...
April 10, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28398713/anti-egfr-antibody-conjugation-of-fucoidan-coated-gold-nanorods-as-novel-photothermal-ablation-agents-for-cancer-therapy
#14
Panchanathan Manivasagan, Subramaniyan Bharathiraja, Madhappan Santha Moorthy, Yun-Ok Oh, Kyeongeun Song, Hansu Seo, Junghwan Oh
The development of novel photothermal ablation agents for cancer nanotheranostics have received a great deal of attention in recent decades. Biocompatible fucoidan (Fu) is used as the coating materials for gold nanorods (AuNRs) and subsequently conjugated with anti-epidermal growth factor receptor monoclonal antibodies (anti-EGFR) as novel photothermal ablation agents for cancer nanotheranostics because of their excellent biocompatibility, biodegradability, nontoxicity, water solubility, photostability, ease of surface modification, strongly enhanced absorption in near-infrared (NIR) regions, target specificity, minimal invasiveness, fast recovery, and prevention of damage to normal tissues...
April 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28395996/atrial-fibrillation-ablation-guided-by-a-novel-nonfluoroscopic-navigation-system
#15
Gabriel Ballesteros, Pablo Ramos, Renzo Neglia, Diego Menéndez, Ignacio García-Bolao
INTRODUCTION AND OBJECTIVES: Rhythmia is a new nonfluoroscopic navigation system that is able to create high-density electroanatomic maps. The aim of this study was to describe the acute outcomes of atrial fibrillation (AF) ablation guided by this system, to analyze the volume provided by its electroanatomic map, and to describe its ability to locate pulmonary vein (PV) reconnection gaps in redo procedures. METHODS: This observational study included 62 patients who underwent AF ablation with Rhythmia compared with a retrospective cohort who underwent AF ablation with a conventional nonfluoroscopic navigation system (Ensite Velocity)...
April 5, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28391185/bipolar-microsecond-pulses-and-insulated-needle-electrodes-for-reducing-muscle-contractions-during-irreversible-electroporation
#16
Chenguo Yao, Shoulong Dong, Yajun Zhao, Yanpeng Lv, Hongmei Liu, Lingyu Gong, Jianhao Ma, Haifeng Wang, Yinghao Sun
To minimize the effect of muscle contractions during irreversible electroporation (IRE), this paper attempts to research the ablation effect and muscle contractions by applying high-frequency irreversible electroporation (H-FIRE) ablation to liver tissue in vivo. METHODS: Insulated needle electrode was designed by painting insulating-coating on the outer surface of the needle electrode tip. Series experiments were conducted using insulated needle electrodes and traditional needle electrodes to apply H-FIRE pulses and traditional monopolar IRE pulses to rabbit liver tissues...
April 4, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28384723/optimum-laser-beam-characteristics-for-achieving-smoother-ablations-in-laser-vision-correction
#17
Shwetabh Verma, Juergen Hesser, Samuel Arba-Mosquera
Purpose: Controversial opinions exist regarding optimum laser beam characteristics for achieving smoother ablations in laser-based vision correction. The purpose of the study was to outline a rigorous simulation model for simulating shot-by-shot ablation process. The impact of laser beam characteristics like super Gaussian order, truncation radius, spot geometry, spot overlap, and lattice geometry were tested on ablation smoothness. Methods: Given the super Gaussian order, the theoretical beam profile was determined following Lambert-Beer model...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28382246/graphene-functionalised-by-laser-ablated-v2o5-for-a-highly-sensitive-nh3-sensor
#18
Margus Kodu, Artjom Berholts, Tauno Kahro, Mati Kook, Peeter Ritslaid, Helina Seemen, Tea Avarmaa, Harry Alles, Raivo Jaaniso
Graphene has been recognized as a promising gas sensing material. The response of graphene-based sensors can be radically improved by introducing defects in graphene using, for example, metal or metal oxide nanoparticles. We have functionalised CVD grown, single-layer graphene by applying pulsed laser deposition (PLD) of V2O5 which resulted in a thin V2O5 layer on graphene with average thickness of ≈0.6 nm. From Raman spectroscopy, it was concluded that the PLD process also induced defects in graphene. Compared to unmodified graphene, the obtained chemiresistive sensor showed considerable improvement of sensing ammonia at room temperature...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/28379278/directly-embroidered-microtubes-for-fluid-transport-in-wearable-applications
#19
Rahim Rahimi, Wuyang Yu, Manuel Ochoa, Babak Ziaie
We demonstrate, for the first time, a facile and low-cost approach for integrating highly flexible and stretchable microfluidic channels into textile-based substrates. The integration of the microfluidics is accomplished by means of directly embroidering surface-functionalized micro-tubing in a zigzag/meander pattern and subsequently coating it with an elastomer for irreversible bonding. We show the utility of the embroidered micro-tubing by developing robust and stretchable drug-delivery and electronic devices...
April 5, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28371837/characterization-of-the-arrhythmogenic-substrate-in-patients-with-arrhythmogenic-right-ventricular-cardiomyopathy-undergoing-ventricular-tachycardia-ablation
#20
Senthil Kirubakaran, Caterina Bisceglia, John Silberbauer, Teresa Oloriz, Giulia Santagostino, Miki Yamase, Giuseppe Maccabelli, Nicola Trevisi, Paolo Della Bella
Aims: Arrhythmogenic right ventricular (RV) cardiomyopathy (ARVC) is associated with ventricular arrhythmias, even without RV structural disease. We aimed to characterize the RV substrate using electroanatomical mapping and to define outcomes following ventricular tachycardia (VT) ablation in patients with and without RV structural abnormalities. Methods and results: Twenty-nine patients with definite or suspected ARVC undergoing VT ablation were classified as 'electrical' and 'structural' cardiomyopathy based on the absence or presence of major structural criteria...
March 20, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
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