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https://www.readbyqxmd.com/read/28646180/sustained-release-from-a-metal-analgesics-entrapped-within-biocidal-silver
#1
Barak Menagen, Rami Pedahzur, David Avnir
Matrices for sustained release of drugs have been based on polymers, biomaterials and oxides. The use of the major family of metals as matrices for sustained release is, to the best of our knowledge, unknown. In this context we describe a new family of bio-composites for sustained release of drugs, namely analgesic drugs entrapped within metallic silver. Synthetic methodologies were developed for the preparation of ibuprofen@Ag, naproxen@Ag, tramadol@Ag and bupivacaine@Ag composites. Detailed kinetic analysis of the release of the drugs from within the metal, is provided, demonstrating that metals can indeed serve as reservoirs for drug release...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28639362/the-effect-of-hospital-biocide-sodium-dichloroisocyanurate-on-the-viability-and-properties-of-clostridium-difficile-spores
#2
Lovleen Tina Joshi, Angelina Welsch, Jennifer Hawkins, Les Baillie
Clostridium difficile is the primary cause of healthcare associated diarrhoea globally and produces spores which are resistant to commonly used biocides and are able persist on contaminated surfaces for months. This study examined the effect of sublethal concentrations of the biocide sodium dichloroisocyanurate (NaDCC) on the viability of spores produced by 21 clinical isolates of C. difficile representing a range of PCR ribotypes. Spores exposed to 500 ppm NaDCC for 10 minutes exhibited between a 4 - 6 log10 reduction in viability which was independent of spore PCR ribotype...
June 22, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/28636352/prevention-of-marine-biofouling-using-the-natural-allelopathic-compound-batatasin-iii-and-synthetic-analogues
#3
Lindon W K Moodie, Rozenn Trepos, Gunnar Cervin, Kari Anne Bråthen, Bente Lindgård, Rigmor Reiersen, Patrick Cahill, Henrik Pavia, Claire Hellio, Johan Svenson
The current study reports the first comprehensive evaluation of a class of allelopathic terrestrial natural products as antifoulants in a marine setting. To investigate the antifouling potential of the natural dihydrostilbene scaffold, a library of 22 synthetic dihydrostilbenes with varying substitution patterns, many of which occur naturally in terrestrial plants, were prepared and assessed for their antifouling capacity. The compounds were evaluated in an extensive screen against 16 fouling marine organisms...
June 21, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28636321/copper-oxide-nanoparticles-induce-lysogenic-bacteriophage-and-metal-resistance-genes-in-pseudomonas-aeruginosa-pao1
#4
Jianhua Guo, Shu-Hong Gao, Ji Lu, Philip L Bond, Willy Verstraete, Zhiguo Yuan
The intensive use of metal-based nanoparticles results in their continuous release into the environment, leading to potential risks for human health and microbial ecosystems. Although previous studies have indicated that nanoparticles may be toxic to microorganisms, there is a scarcity of data available to assess the underlying molecular mechanisms of inhibitory and biocidal effects of nanoparticles on microorganisms. This study used physiological experiments, microscopy, Live/Dead staining and the genome-wide RNA sequencing to investigate the multiple responses of Pseudomonas aeruginosa to the exposure of copper oxide nanoparticles (CuO NPs)...
June 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28622988/organotins-and-new-antifouling-biocides-in-water-and-sediments-from-three-korean-special-management-sea-areas-following-ten-years-of-tributyltin-regulation-contamination-profiles-and-risk-assessment
#5
Nguyen Hoang Lam, Hee-Ho Jeong, Su-Dong Kang, Dae-Jin Kim, Mi-Jo Ju, Toshihiro Horiguchi, Hyeon-Seo Cho
A simultaneous monitoring study on organotins (butyltins and phenyltins) and most frequently used alternative antifouling biocides (Irgarol 1051, Diuron, Sea-Nine 211 and M1) in water and sediments (n=44) collected from three Special Management Sea Areas operated by Korean government. The lower concentration of butyltins (BTs) than that of new antifouling biocides (NEW) was found in water but the significant greater concentration of BTs than that of NEW was still found in sediments. The tributyltin (TBT) levels in water exceeded the chronic criterion to protect seawater aquatic life at several sites...
June 13, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28622579/evidence-of-promising-biological-pharmacological-activities-of-the-sertraline-based-copper-complex-serh2-2-cucl4
#6
Nancy Martini, Juliana E Parente, Maria Eugenia Toledo, Graciela E Escudero, Carlos H Laino, Juan José Martínez Medina, Gustavo A Echeverría, Oscar E Piro, Luis Lezama, Patricia A M Williams, Evelina G Ferrer
In the current study the ability of copper complex to exert multiple biological activities is combined with the pharmacological action of sertraline (SerH2Cl, antidepressant drug). The hydrated and anhydrous forms of the tetrachlorocuprate(II) salts, namely (SerH2)2[CuCl4]·½H2O and (SerH2)2[CuCl4], were synthesized and characterized by physicochemical methods. The crystal structures were determined by X-ray diffraction methods. The hydrate complex crystallizes in the monoclinic P21 space group with a=8.0807(2) Å, b=36...
June 1, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28620858/toxicity-assessment-of-five-emerging-pollutants-alone-and-in-binary-or-ternary-mixtures-towards-three-aquatic-organisms
#7
Carole Di Poi, Katherine Costil, Valérie Bouchart, Marie-Pierre Halm-Lemeille
Despite a growing scientific attention on ecological impact of emerging pollutants (EPs) such as pharmaceuticals, personal care products, and pesticides, knowledge gaps remain regarding mixture toxicity and effects on aquatic organisms. Several EPs were screened in seawater (Normandy, France), and the ecotoxicity of five compounds, chosen on their occurrence in ecosystems and use worldwide, was assessed and were the biocides methylparaben (MP) and triclosan (TCS), a pesticide degradation product (AMPA), and the pharmaceuticals venlafaxine (VEN) and carbamazepine (CBZ)...
June 15, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28615847/larvicidal-potency-of-marine-actinobacteria-isolated-from-mangrove-environment-against-aedes-aegypti-and-anopheles-stephensi
#8
S Balakrishnan, P Santhanam, M Srinivasan
The marine soil samples were collected from different locations of Parangipettai mangrove ecosystem, Vellar estuary, southeast coast of India. Totally 30 different marine actinobacteria were isolated by serial dilution plate technique on starch casein agar medium. The isolated actinobacteria were investigated for their larvicidal activity against Aedes aegypti and Anopheles stephensi mosquitoes. Streptomyces fungicidicus, S. griseus, S. albus, S. alboflavus and S. rochei were identified as potential biocide producers...
June 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28613232/off-the-shelf-fouling-management
#9
REVIEW
Daniel Rittschof
This chapter tells the story of a research thread that identified and modified a pharmaceutical that could be a component of environmentally benign fouling management coatings. First, I present the background context of biofouling and how fouling is managed. The major target of the research is disrupting transduction of a complex process in all macrofouling organisms: metamorphosis. Using a bioassay directed approach we first identified a pharmaceutical candidate. Then, based on structure function studies coupled with laboratory and field bioassays, we simplified the molecule, eliminating halogens and aromatic rings to a pharmacophore that could be readily broken down by bacteria...
June 14, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28611763/lauroyl-arginate-ethyl-blocks-the-iron-signals-necessary-for-pseudomonas-aeruginosa-biofilm-development
#10
Taek-Seung Kim, So-Young Ham, Bernie B Park, Youngjoo Byun, Hee-Deung Park
Pseudomonas aeruginosa is a ubiquitous gram-negative bacterium capable of forming a biofilm on living and non-living surfaces, which frequently leads to undesirable consequences. We found that lauroyl arginate ethyl (LAE), a synthetic non-oxidizing biocide, inhibited biofilm formation by P. aeruginosa at a sub-growth inhibitory concentration under both static and flow conditions. A global transcriptome analysis was conducted using a gene chip microarray to identify the genes targeted by LAE. In response to LAE treatment, P...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28609707/antibacterial-properties-of-sophorolipid-modified-gold-surfaces-against-gram-positive-and-gram-negative-pathogens
#11
Claire Valotteau, Ibrahim M Banat, Christopher A Mitchell, Helen Lydon, Roger Marchant, Florence Babonneau, Claire-Marie Pradier, Niki Baccile, Vincent Humblot
Sophorolipids are bioderived glycolipids displaying interesting antimicrobial properties. We show that they can be used to develop biocidal monolayers against Listeria ivanovii, a Gram-positive bacterium. The present work points out the dependence between the surface density and the antibacterial activity of grafted sophorolipids. It also emphasizes the broad spectrum of activity of these coatings, demonstrating their potential against both Gram-positive strains (Enteroccocus faecalis, Staphylococcus epidermidis, Streptococcus pyogenes) and Gram-negative strains (Escherichia coli, Pseudomonas aeruginosa and Salmonella typhymurium)...
June 2, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28606544/mining-marine-shell-wastes-for-polyelectrolyte-chitosan-anti-biofoulants-fabrication-of-high-performance-economic-and-ecofriendly-anti-biofouling-coatings
#12
Reda F M Elshaarawy, Fatma H A Mustafa, Lasse van Geelen, Amaal E A Abou-Taleb, Hermine R Z Tadros, Rainer Kalscheuer, Christoph Janiak
Banning organotins as antifouling biocides in 2003 was the starting point for many researchers to search for novel economic and environmentally-friendly anti-fouling biocides. In our present contribution, we have successfully functionalized a natural biopolymer, chitosan (CS), isolated from marine wastes with polyelectrolyte brushes akin to ionic liquids. These antifouling biopolymers anchoring polyelectrolyte brushes were in vitro assessed for their ability to eradicate or inhibit the Staphylococcal/Escherichia biofilms...
September 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28605860/transport-of-silver-nanoparticles-by-runoff-and-erosion-a-flume-experiment
#13
Karrar N M Mahdi, Meindert Commelin, Ruud J B Peters, Jantiene E M Baartman, Coen Ritsema, Violette Geissen
Silver nanoparticles (AgNPs) are being used in many products as they have unique antimicrobial-biocidal properties. After disposal of these products AgNPs can reach the soil environment possibly affecting soil organisms and disrupting plants. This work aimed to study the transport of AgNPs by water and sediment during overland flow and soil erosion. This was done in a laboratory setting, using a flume and rainfall simulator. A low concentration of AgNPs (50μg·kg(-1)) was applied to two soil-flumes with slope percentages of 20% and 10%...
June 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28605289/effect-of-sub-lethal-concentrations-of-biocides-on-the-structural-parameters-and-viability-of-the-biofilms-formed-by-salmonella-typhimurium
#14
Rosa Capita, Laura Buzón-Durán, Félix Riesco-Peláez, Carlos Alonso-Calleja
This study aimed to investigate the effect of sub-minimum inhibitory concentrations (sub-MICs) of three food-grade biocides (benzalkonium chloride -BZK-, trisodium phosphate -TSP-, and sodium hypochlorite -SHY-) on Salmonella biofilms. The structural parameters and bacterial viability of the biofilms formed by a S. Typhimurium isolate from poultry was investigated by means of confocal laser scanning microscopy after staining with SYTO9 and propidium iodide. The MIC values for Salmonella cells before exposure to subinhibitory concentrations of biocides were 8...
June 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/28604168/dynamics-of-silver-elution-from-functionalised-antimicrobial-nanofiltration-membranes
#15
S Choudhari, O Habimana, J Hannon, A Allen, E Cummins, E Casey
In an effort to mitigate biofouling on thin film composite membranes such as nanofiltration and reverse osmosis, a myriad of different surface modification strategies has been published. The use of silver nanoparticles (Ag-NPs) has emerged as being particularly promising. Nevertheless, the stability of these surface modifications is still poorly understood, particularly under permeate flux conditions. Leaching or elution of Ag-NPs from the membrane surface can not only affect the antimicrobial characteristics of the membrane, but could also potentially present an environmental liability when applied in industrial-scale systems...
July 2017: Biofouling
https://www.readbyqxmd.com/read/28601522/comparative-toxicological-effects-of-two-antifouling-biocides-on-the-marine-diatom-chaetoceros-lorenzianus-damage-and-post-exposure-recovery
#16
Pooja Chavan, Rajesh Kumar, Ramalingam Kirubagaran, Vayalam P Venugopalan
Antifouling biocides are commonly used in coastal electric power stations to prevent biofouling in their condenser cooling systems. However, the environmental impact of the chemical biocides is less understood than the thermal stress effects caused by the condenser effluents. In this study, Chaetoceros lorenzianus, a representative marine diatom, was used to analyse the toxicity of two antifouling biocides, chlorine and chlorine dioxide. The diatom cells were subjected to a range of concentrations of the biocides (from 0...
June 8, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28593517/ginger-extract-as-green-biocide-to-control-microbial-corrosion-of-mild-steel
#17
Jayaraman Narenkumar, Punniyakotti Parthipan, Ayyakkannu Usha Raja Nanthini, Giovanni Benelli, Kadarkarai Murugan, Aruliah Rajasekar
In latest years, various techniques and chemicals have been used for the control of microbial influenced corrosion (MIC) of metals. The application of botanical-based biocides is one of the effective and practical techniques in the fight against MIC. In the present study, the role of aqueous extract of ginger (Zingiber officinale) (GIE) as green biocide to control MIC of mild steel 1010 (MS) in a cooling water system was investigated. Biocorrosion behavior of Bacillus thuringiensis EN2 on MS and its control by GIE was analyzed by electrochemical measurements...
June 2017: 3 Biotech
https://www.readbyqxmd.com/read/28586403/evolution-of-class-1-integrons-mobilization-and-dispersal-via-food-borne-bacteria
#18
Timothy M Ghaly, Louise Chow, Amy J Asher, Liette S Waldron, Michael R Gillings
Class 1 integrons have played a major role in the global dissemination of antibiotic resistance. Reconstructing the history of class 1 integrons might help us control further spread of antibiotic resistance by understanding how human activities influence microbial evolution. Here we describe a class 1 integron that represents an intermediate stage in the evolutionary history of clinical integrons. It was embedded in a series of nested transposons, carried on an IncP plasmid resident in Enterobacter, isolated from the surface of baby spinach leaves...
2017: PloS One
https://www.readbyqxmd.com/read/28582701/oxidative-stress-in-the-algae-chlamydomonas-reinhardtii-exposed-to-biocides
#19
Ana Catarina Almeida, Tânia Gomes, Katherine Langford, Kevin V Thomas, Knut Erik Tollefsen
The toxicity of biocides can be associated with the formation of reactive oxygen species (ROS) and subsequent oxidative damage, interfering with the normal function of photosynthetic organisms. This study investigated the formation and effects of ROS in the unicellular green algae Chlamydomonas reinhardtii exposed to three environmentally relevant biocides, aclonifen, dichlofluanid and triclosan. After a first screening to identify which biocides induced ROS, a 24h multi-endpoint analysis was used to verify the possible consequences...
May 31, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28576053/antibacterial-sno2-nanorods-as-efficient-fillers-of-poly-propylene-fumarate-co-ethylene-glycol-biomaterials
#20
Ana M Díez-Pascual, Angel L Díez-Vicente
Antibacterial and biocompatible SnO2 nanorods have been easily synthesized through a hydrothermal process with the aid of a cationic surfactant, and incorporated as nanoreinforcements in poly(propylene fumarate-co-ethylene glycol) (P(PF-co-EG)) copolymer crosslinked with N-vinyl-pyrrolidone (NVP) by sonication and thermal curing. The nanorods were randomly and individually dispersed inside the P(PF-co-EG) network, and noticeably increased the thermal stability, hydrophilicity, degree of crystallinity, protein absorption capability as well as stiffness and strength of the matrix, whilst decreased its level of porosity and biodegradation rate...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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