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Soklida Hong, Thunyalux Ratpukdi, Jayaraman Sivaguru, Eakalak Khan
Glutaraldehyde (GA) has been used extensively as a biocide in hydraulic fracturing fluid leading to its presence in oil and gas produced water. In this study, photolysis was used to degrade GA from brine solutions simulating produced water. Photolysis of GA was performed under ultraviolet (UV) irradiation. GA can be photolyzed by UV at all studied conditions with the efficiency ranging from 52 to 85% within one hour irradiation. Photolysis of GA followed pseudo-first order kinetics. A photolysis rate constant of GA at 0...
April 11, 2018: Journal of Hazardous Materials
Mar Siles-Lucas, Adriano Casulli, Roberto Cirilli, David Carmena
Human cystic and alveolar echinococcosis are helmintic zoonotic diseases caused by infections with the larval stages of the cestode parasites Echinococcus granulosus and E. multilocularis, respectively. Both diseases are progressive and chronic, and often fatal if left unattended for E. multilocularis. As a treatment approach, chemotherapy against these orphan and neglected diseases has been available for more than 40 years. However, drug options were limited to the benzimidazoles albendazole and mebendazole, the only chemical compounds currently licensed for treatment in humans...
April 20, 2018: PLoS Neglected Tropical Diseases
Jean-Yves Maillard
Biocides and formulated biocides are used worldwide for an increasing number of applications despite tightening regulations in Europe and in the United States. One concern is that such intense usage of biocides could lead to increased bacterial resistance to a product and cross-resistance to unrelated antimicrobials including chemotherapeutic antibiotics. Evidence to justify such a concern comes mostly from the use of health care-relevant bacterial isolates, although the number of studies of the resistance characteristics of veterinary isolates to biocides have increased the past few years...
April 2018: Microbiology Spectrum
Ana Sanchis, J-Pablo Salvador, Katrina Campbell, Christopher T Elliott, Weilin L Shelver, Qing X Li, M-Pilar Marco
The development of a fluorescent multiplexed microarray platform able to detect and quantify a wide variety of pollutants in seawater is reported. The microarray platform has been manufactured by spotting 6 different bioconjugate competitors and it uses a cocktail of 6 monoclonal or polyclonal antibodies raised against important families of chemical pollutants such as triazine biocide (i.e. Irgarol 1051®), sulfonamide and chloramphenicol antibiotics, polybrominated diphenyl ether flame-retardant (PBDE, i.e...
July 1, 2018: Talanta
Nadin Shagaghi, Enzo A Palombo, Andrew H A Clayton, Mrinal Bhave
Antimicrobial peptides (AMPs) have been established over millennia as powerful components of the innate immune system of many organisms. Due to their broad spectrum of activity and the development of host resistance against them being unlikely, AMPs are strong candidates for controlling drug-resistant pathogenic microbial pathogens. AMPs cause cell death through several independent or cooperative mechanisms involving membrane lysis, non-lytic activity, and/or intracellular mechanisms. Biochemical determinants such as peptide length, primary sequence, charge, secondary structure, hydrophobicity, amphipathicity and host cell membrane composition together influence the biological activities of peptides...
April 12, 2018: World Journal of Microbiology & Biotechnology
Li Yao, Yin-Zhi Lv, Li-Juan Zhang, Wang-Rong Liu, Jian-Liang Zhao, You-Sheng Liu, Qian-Qian Zhang, Guang-Guo Ying
Personal care products (PCPs) are ubiquitous in aquatic environments owing to the continuous discharge of domestic wastewater from highly urbanized regions. These PCPs can be adsorbed by fish and thereafter usually enter the bile of the fish through biliary excretion. In this study, a sensitive method based on a combination of hybrid solvent precipitation and dispersive solid phase extraction (d-SPE) purification was developed to simultaneously extract and detect 24 PCPs, namely, 16 biocides, 4 synthetic musks, and 4 benzotriazoles, from fish bile...
April 5, 2018: Journal of Chromatography. A
R Beiras, T Tato
Pentachlorophenol (PCP) is a organochlorine biocide that, unlike most other organochlorines, is still in use as timber preservative. Its water solubility, high toxicity, bioaccumulation potential, and the concentrations reported in estuarine waters (up to 0.1 µg L-1 ) indicate it may pose a risk in coastal environments. Aquatic environrmental regulations are commonly based on standard freshwater organisms that may not represent the sensitivity of marine species. The present study consists of a water quality criteira reevalutation of PCP in coastal waters based on toxicity tests conducted recording sensitive endpoints of marine species representative of coastal ecosystems, following QA/QC standard procedures...
April 7, 2018: Ecotoxicology
Wen Ma, Magdalena Panecka, Nathalie Tufenkji, Md Saifur Rahaman
The ability of bacteriophages to infect and destroy specific bacteria makes them promising antimicrobial agents in industrial processes. In this study, potential strategies of bacteriophage-facilitated biofouling control during membrane ultrafiltration (UF) were investigated through use of the model T4 bacteriophage and the model host bacterium, Escherichia coli. In the dead-end filtration mode, phages were immobilized on the membrane surface to serve as biocidal agents and inhibit the propagation of bacteria in situ...
March 30, 2018: Journal of Colloid and Interface Science
Jana Minarovičová, Adriana Véghová, Mária Mikulášová, Romana Chovanová, Katarína Šoltýs, Hana Drahovská, Eva Kaclíková
Listeria monocytogenes is a serious foodborne pathogen capable of persisting in food processing environments. Tolerance to disinfectants used in industrial settings constitutes an important factor of Listeria survival. In the present study, the mechanism of tolerance to benzalkonium chloride (BAC) was investigated in 77 L. monocytogenes isolates from a meat facility. By PCR approach, the mdrL and lde chromosomal efflux pump genes were detected in all isolates. No isolate was positive for qacH and emrE genes...
April 6, 2018: Antonie Van Leeuwenhoek
Basma A Omran, Hussein N Nassar, Nesreen A Fatthallah, A Hamdy, Einas H El-Shatoury, Nour Sh El-Gendy
AIMS: Since mycosynthesis of metal nanoparticles is advertised as a promising and eco- friendly approach. Thus, the present study aims to investigate the capability of Aspergillus brasiliensis ATCC 16404 for mycosynthesis of silver nanoparticles (AgNPs). METHODS AND RESULTS: One-factor-at-a-time-technique was used to study the effect of different physicochemical parameters; the reaction time, pH, temperature, different stirring rates, illumination and finally the different concentrations of silver nitrate and fungal biomass on the mycosynthesis of AgNPs...
April 6, 2018: Journal of Applied Microbiology
Lilit Tonoyan, Aoife Boyd, Gerard T A Fleming, Ruairi Friel, Carol M Gately, Paul H Mc Cay, Vincent O'Flaherty
Novel biocides, which avoid the induction of cross-resistance to antibiotics, are an urgent societal requirement. Here, we compared the cytotoxic and bactericidal effects of a new antimicrobial agent, the iodo-thiocyanate complex (ITC), with those of the common antiseptics, hydrogen peroxide (H2 O2 ), povidone iodine (PVP-I) and Lugol's iodine (Lugol). The antimicrobials were co-incubated for 10 min with HeLa and Escherichia coli cells in the presence and absence of organic matter (Dulbecco's modified Eagle's medium, supplemented with 10% fetal bovine serum)...
April 2, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
Andrew Elohim Elohim Laloo, Justin Wei, Dongbo Wang, Shaman Narayanasamy, Inka Vanwonterghem, David W Waite, Jason Steen, Anne Kaysen, Anna Heintz-Buschart, Qilin Wang, Benjamin L Schulz, Amanda S Nouwens, Paul Wilmes, Philip Hugenholtz, Zhiguo Yuan, Philip L Bond
Free Nitrous Acid (FNA) exerts a broad range of antimicrobial effects on bacteria although susceptibility varies considerably amongst microorganisms. Among nitrifiers found in activated sludge of wastewater treatment processes (WWTP), nitrite oxidising bacteria (NOB) are more susceptible to FNA compared to ammonia oxidising bacteria (AOB). This selective inhibition of NOB over AOB in WWTP bypasses nitrate production and improves the efficiency and costs of the nitrogen removal process in both the activated sludge and anaerobic ammonium oxidation (Anammox) system...
April 5, 2018: Environmental Science & Technology
Bothyna Ghanem, Randa Nayef Haddadin
Background: Antibiotic resistance of environmental Escherichia coli in hospitals could be increased due to extensive use of biocides resulting in serious infections. In this study, the prevalence of antibiotic resistance of environmental isolates of E. coli from hospitals and household settings were evaluated and compared. In addition, the association between biocide minimum inhibitory concentration (MIC) and multiple drug resistance (MDR) was investigated. Methods: Environmental samples were collected from different homes and hospitals in Amman, Jordan...
2018: Antimicrobial Resistance and Infection Control
Ashajyothi C, Harish K Handral, Chandrakanth Kelmani R
During the present time, anti-microbial features of copper (Cu) and zinc oxide (ZnO) nanoparticles (NPs) are extensively used to combat the growth of pathogenic microbes. CuNPs and ZnONPs are recurrently used in cosmetics, medicine and food additives, and their potential for toxic impacts on human and ecosystem is of high concern. In this study, the fate and toxicity of 16- to 96-nm-ranged biosynthesized copper (Bio-CuNPs) and zinc oxide (Bio-ZnONPs) was assessed in male Wistar rats. In vivo exposures of the two nanoparticles are achieved through two different administration routes namely, intraperitoneal (i/p) and intravenous (i/v) injections...
April 3, 2018: Nanoscale Research Letters
Vinicius Bermond Marques, Rodrigo Alves Faria, Leonardo Dos Santos
Organotins (OTs) are pollutants that are used widely by industry as disinfectants, pesticides, and most frequently as biocides in antifouling paints. This mini-review presents the main evidences from the literature about morphophysiological changes induced by OTs in the mammal endocrine system, focusing on the metabolism and reproductive control. Similar to other toxic compounds, the main effects with potential health risks to humans and experimental animals are not only related to dose and time of exposure but also to age, gender, and tissue/cell exposed...
2018: Frontiers in Endocrinology
Bruno D Mattos, Blaise L Tardy, Mohammadi Pezhman, Tero Kämäräinen, Markus Linder, Wido H Schreiner, Washington L E Magalhães, Orlando J Rojas
Biocides are essential for crop protection, packaging and several other biosystem applications. Therein, properties such as tailored and controlled release are paramount in the development of sustainable biocide delivery systems. We explore the self-similar nano-organized architecture of biogenic silica particles to achieve high biocide payload. The high surface area accessibility of the carrier allowed us to develop an efficient, low energy loading strategy, reaching significant dynamic loadings of up to 100 mg·g-1 ...
April 3, 2018: Scientific Reports
Matthew J Shepherd, Ginny Moore, Matthew E Wand, J Mark Sutton, Lucy J Bock
BACKGROUND: Octenidine is frequently used for infection prevention in neonatal and burn intensive care units, where Pseudomonas aeruginosa has caused nosocomial outbreaks. AIM: To investigate the efficacy and impact of using octenidine against P. aeruginosa. METHODS: Seven clinical isolates of P. aeruginosa were exposed to increasing concentrations of octenidine over several days. Fitness, minimum bactericidal concentrations after 1 minute, 5 minutes and 24 hours, and minimum inhibitory concentrations of a variety of antimicrobials were measured for the parental and octenidine-adapted P...
March 31, 2018: Journal of Hospital Infection
Stefanie Wieck, Oliver Olsson, Klaus Kümmerer
The emission sources of biocidal active substances in households have been under discussion since these substances have been detected frequently in municipal wastewater and receiving surface water bodies. Therefore, the goal of this study was to investigate the products responsible for the emission of these substances to wastewater. We analysed the wastewater of two streets for a set of biocidal active substances. Time-proportional sampling was conducted for one week of each season during one year in each street...
March 29, 2018: Environment International
Rachel Mathew, Ralph P Cooney, Jenny Malmstrom, Colin S Doyle
A siloxane surface-anchored quaternary ammonium salt (AQAS: Biosafe HM4100 in this study) has been chemisorbed onto a quartz substrate. The aim of this study is to elucidate, using Atomic Force Microscopy (AFM) and X-Ray Photoelectron Spectroscopy (XPS), the structure of the chemisorbed AQAS layers. The AQAS biocide includes a C18 alkyl chain previously invoked in lysis potency. The AQAS coverage appears in zones on the surface which include a first layer (c.2.6nm) and multi-layering which were explored using AFM...
March 30, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Chandni Khurana, Bhupendra Chudasama
Antimicrobial characteristics of metals reveal that Ag despite its economic constraints remains the most popular antibiotic agent. Antimicrobial characteristics of copper nanoparticles (CNPs) are not well understood. To our knowledge, no systematic comparative study on microbial properties of silver nanoparticles (SNPs) and CNPs exists. In this article, a comparative study on microbial properties of engineered metal nanoantibiotics against clinically important strains has been attempted. Our results indicate that biocidal activities of CNPs are better than SNPs...
2018: International Journal of Nanomedicine
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