keyword
MENU ▼
Read by QxMD icon Read
search

Novel antibiotic

keyword
https://www.readbyqxmd.com/read/29145163/spread-of-multidrug-resistant-escherichia-coli-harboring-integron-via-swine-farm-waste-water-treatment-plant
#1
Jin-Hyeong Park, Young-Ji Kim, Binn-Kim, Kun-Ho Seo
Wastewater treatment plants (WWTPs) that release treated wastewater into the environment have emerged as a major threat to public health. In this study, we investigated Escherichia coli load and antibiotic-resistance profiles across different treatment processes at a swine farm WWTP. The frequency of the detection of class 1 and 2 integrons, and their association with antibiotic resistance, were also analyzed. Samples were obtained at each of five sampling sites that represented each processing step within the WWTP...
November 13, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29145096/sulfaguanidine-cocrystals-synthesis-structural-characterization-and-their-antibacterial-and-hemolytic-analysis
#2
Syed Sibte Asghar Abidi, Yasser Azim, Shahper Nazeer Khan, Asad U Khan
Sulfaguanidine (SG), belongs to the class of sulfonamide drug used as an effective antibiotic. In the present work, using crystal engineering approach two novel cocrystals of SG were synthesized (SG-TBA and SG-PT) with thiobarbutaric acid (TBA) and 1,10-phenanthroline (PT), characterized by solid state techniques viz., powder X-ray diffraction (PXRD), fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC) and the crystal structures were determined by single crystal X-ray diffraction studies...
November 11, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29144725/inhibition-of-acinetobacter-derived-cephalosporinase-adc-exploring-the-carboxylate-recognition-site-using-novel-%C3%AE-lactamase-inhibitors
#3
Emilia Caselli, Chiara Romagnoli, Rachel A Powers, Magdalena A Taracila, Alexandra A Bouza, Hollister C Swanson, Kali A Smolen, Francesco Fini, Bradley J Wallar, Robert A Bonomo, Fabio Prati
Boronic acids are attracting a lot of attention as -lactamase inhibitors, and in particular compound S02030 (Ki = 44 nM) proved to be a good lead compound against ADC-7 (Acinetobacter Derived Cephalosporinase), one of the most significant resistance determinants in A. baumannii. The atomic structure of the ADC-7/S02030 complex highlighted the importance of critical structural determinants for recognition of the boronic acids. Herein, to elucidate the role in recognition of the R2-carboxylate, which mimics the C3/C4 found in -lactams, we designed, synthesized, and characterized six derivatives of S02030 (3a)...
November 16, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29142389/bioactive-constituents-radical-scavenging-and-antibacterial-properties-of-the-leaves-and-stem-essential-oils-from-peperomia-pellucida-l-kunth
#4
Sunday O Okoh, Benson C Iweriebor, Omobola O Okoh, Anthony I Okoh
Background: Peperomia pellucida is an annual herbaceous ethnomedicinal plant used in the treatment of a variety of communicable and noncommunicable diseases in the Amazon region. Objective: The study aimed at profiling the bioactive constituents of the leaves and stem essential oils (LEO and SEO) of P. pellucida, their in vitro antibacterial and radical scavenging properties as probable lead constituents in the management of oxidative stress and infectious diseases...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29141637/molecules-produced-by-probiotics-prevent-enteric-colibacillosis-in-pigs
#5
Ricardo Nordeste, Akalate Tessema, Sapana Sharma, Zlatko Kovač, Chuan Wang, Rocio Morales, Mansel William Griffiths
BACKGROUND: With the advent of antimicrobial resistance in animal pathogens, novel methods to combat infectious diseases are being sought. Among these, probiotics have been proposed as a means of promoting animal health but problems with their use has been reported. Research has demonstrated that bioactive molecules produced during the growth of certain probiotics interfere with bacterial cell-to-cell communication, which consequently results in an attenuation of virulence in a number of pathogens, including E...
November 15, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29140285/chitosan-cyclodextrin-tpp-nanoparticles-loaded-with-quercetin-as-novel-bacterial-quorum-sensing-inhibitors
#6
Hao Thanh Nguyen, Francisco M Goycoolea
The widespread emergence of antibiotic-resistant bacteria has highlighted the urgent need of alternative therapeutic approaches for human and animal health. Targeting virulence factors that are controlled by bacterial quorum sensing (QS), seems a promising approach. The aims of this study were to generate novel nanoparticles (NPs) composed of chitosan (CS), sulfo-butyl-ether-β-cyclodextrin (Captisol(®)) and/or pentasodium tripolyphosphate using ionotropic gelation technique, and to evaluate their potential capacity to arrest QS in bacteria...
November 15, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29140081/the-human-milk-glycome-as-a-defense-against-infectious-diseases-rationale-challenges-and-opportunities
#7
Kelly M Craft, Steven D Townsend
Each year over 3 million people die from infectious diseases with most of these deaths being poor and young children who live in low- and middle-income countries. Infectious diseases emerge for a multitude of reasons. On the social front, reasons include a breakdown of public health standards, international travel, and immigration (for financial, civil, and social reasons). At the molecular level, the modern rise of infectious diseases is tied to the juxtaposition of drug-resistant pathogens and a lack of new antimicrobials...
November 15, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29139571/human-prosthetic-joint-infections-are-associated-with-myeloid-derived-suppressor-cells-mdscs-implications-for-infection-persistence
#8
Cortney E Heim, Debbie Vidlak, Jessica Odvody, Curtis W Hartman, Kevin L Garvin, Tammy Kielian
Prosthetic joint infection (PJI) is a devastating complication of joint arthroplasty surgery typified by biofilm formation. Currently, mechanisms whereby biofilms persist and evade immune-mediated clearance in immune competent patients remain largely ill-defined. Therefore, the current study characterized leukocyte infiltrates and inflammatory mediator expression in tissues from patients with PJI compared to aseptic loosening. CD33(+) HLA-DR(-) CD66b(+) CD14(-/low) granulocytic myeloid-derived suppressor cells (G-MDSCs) were the predominant leukocyte population at sites of human PJI compared to aseptic tissues...
November 15, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29139494/discovery-of-nicoyamycin-a-an-inhibitor-of-uropathogenic-escherichia-coli-growth-in-low-iron-environments
#9
Laura A Mike, Ashootosh Tripathi, Connor M Blankenship, Alyssa Saluk, Pamela J Schultz, Giselle Tamayo-Castillo, David H Sherman, Harry L T Mobley
High-throughput screening and activity-guided purification identified nicoyamycin A, a natural product comprised of an uncommon 3-methyl-1,4-dioxane ring incorporated into a desferrioxamine-like backbone via a spiroaminal linkage. Nicoyamycin A potently inhibits uropathogenic Escherichia coli growth in low iron medium, a promising step toward developing novel antibiotics to treat recalcitrant bacterial infections.
November 15, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29138537/development-of-novel-ultrashort-antimicrobial-peptide-nanoparticles-with-potent-antimicrobial-and-antibiofilm-activities-against-multidrug-resistant-bacteria
#10
Ammar Almaaytah, Gubran Khalil Mohammed, Ahmad Abualhaijaa, Qosay Al-Balas
Conventional antibiotics are facing strong microbial resistance that has recently reached critical levels. This situation is leading to significantly reduced therapeutic potential of a huge proportion of antimicrobial agents currently used in clinical settings. Antimicrobial peptides (AMPs) could provide the medical community with an alternative strategy to traditional antibiotics for combating microbial resistance. However, the development of AMPs into clinically useful antibiotics is hampered by their relatively low stability, toxicity, and high manufacturing costs...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29138482/valgamicin-c-a-novel-cyclic-depsipeptide-containing-the-unusual-amino-acid-cleonine-and-related-valgamicins-a-t-and-v-produced-by-amycolatopsis-sp-ml1-hf4
#11
Hideki Hashizume, Kiyoko Iijima, Kazuma Yamashita, Tomoyuki Kimura, Shun-Ichi Wada, Ryuichi Sawa, Masayuki Igarashi
In the course of optimizing pargamicin A production in Amycolatopsis sp. ML1-hF4, we discovered novel cyclic depsipeptide compounds in the broth and designated them valgamicins A, C, T and V. The structures of these molecules were determined by spectroscopic studies, advanced Marfey's method and X-ray crystal structural analysis. Valgamicin C contains the extremely rare amino acid cleonine. To our knowledge, this is the first report of a cleonine-containing metabolite from a naturally isolated microorganism without any breeding or mutation treatment...
November 15, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/29138303/cxc-chemokines-exhibit-bactericidal-activity-against-multidrug-resistant-gram-negative-pathogens
#12
Matthew A Crawford, Debra J Fisher, Lisa M Leung, Sara Lomonaco, Christine Lascols, Antonio Cannatelli, Tommaso Giani, Gian Maria Rossolini, Yohei Doi, David R Goodlett, Marc W Allard, Shashi K Sharma, Erum Khan, Robert K Ernst, Molly A Hughes
The continued rise and spread of antimicrobial resistance among bacterial pathogens pose a serious challenge to global health. Countering antimicrobial-resistant pathogens requires a multifaceted effort that includes the discovery of novel therapeutic approaches. Here, we establish the capacity of the human CXC chemokines CXCL9 and CXCL10 to kill multidrug-resistant Gram-negative bacteria, including New Delhi metallo-beta-lactamase-1-producing Klebsiella pneumoniae and colistin-resistant members of the family Enterobacteriaceae that harbor the mobile colistin resistance protein MCR-1 and thus possess phosphoethanolamine-modified lipid A...
November 14, 2017: MBio
https://www.readbyqxmd.com/read/29137865/aminomethylation-of-heliomycin-preparation-and-anticancer-characterization-of-the-first-series-of-semi-synthetic-derivatives
#13
Georgy Y Nadysev, Alexander S Tikhomirov, Ming-Hung Lin, Ya-Ting Yang, Lyubov G Dezhenkova, Huei-Yu Chen, Dmitry N Kaluzhny, Dominique Schols, Alexander A Shtil, Andrey E Shchekotikhin, Pin Ju Chueh
A series of 4-aminomethyl derivatives of heliomycin 1 was prepared using the Mannich reaction. The modification significantly improved aqueous solubility of the initially poorly soluble antibiotic. Testing the antiproliferative efficacy revealed a potent activity of heliomycin as well as its new derivatives on a panel of mammalian tumor cells including drug resistant variants. In contrast to 1 the new derivatives 7a, 7l, 7p generated a high level of ROS associated with induction of apoptosis in T24 bladder cancer cells...
October 19, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29137648/lesr-is-a-novel-upstream-regulator-that-controls-downstream-clp-expression-to-modulate-antibiotic-hsaf-biosynthesis-and-cell-aggregation-in-lysobacter-enzymogenes-oh11
#14
Huiyong Xu, Ruping Wang, Yangyang Zhao, Zheng Qing Fu, Guoliang Qian, Fengquan Liu
BACKGROUND: Heat-stable antifungal factor (HSAF) is a polycyclic tetramate macrolactam secondary metabolite that exhibits broad-spectrum inhibitory activities against filamentous fungal pathogens. The native yield of this chemical is low. It is also a great challenge to synthesize HSAF artificially, due to its complex structure. Understanding the regulatory mechanism underlying HSAF biosynthesis could provide genetic basis for engineering high HSAF-producing strain. The transcription factor Clp is a global regulator that controls bacterial pathogenicity and the expression of one hundred related genes in the phytopathogenic bacterium Xanthomonas campestris pv...
November 14, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/29137134/an-overview-of-the-bacterial-carbonic-anhydrases
#15
REVIEW
Claudiu T Supuran, Clemente Capasso
Bacteria encode carbonic anhydrases (CAs, EC 4.2.1.1) belonging to three different genetic families, the α-, β-, and γ-classes. By equilibrating CO₂ and bicarbonate, these metalloenzymes interfere with pH regulation and other crucial physiological processes of these organisms. The detailed investigations of many such enzymes from pathogenic and non-pathogenic bacteria afford the opportunity to design both novel therapeutic agents, as well as biomimetic processes, for example, for CO₂ capture. Investigation of bacterial CA inhibitors and activators may be relevant for finding antibiotics with a new mechanism of action...
November 11, 2017: Metabolites
https://www.readbyqxmd.com/read/29137129/design-and-evaluation-of-novel-polymyxin-fluorescent-probes
#16
Bo Yun, Kade D Roberts, Philip E Thompson, Roger L Nation, Tony Velkov, Jian Li
Polymyxins (polymyxin B and colistin) are cyclic lipopeptide antibiotics that serve as a last-line defence against Gram-negative "superbugs". In the present study, two novel fluorescent polymyxin probes were designed through regio-selective modifications of the polymyxin B core structure at the N-terminus and the hydrophobic motif at positions 6 and 7. The resulting probes, FADDI-285 and FADDI-286 demonstrated comparable antibacterial activity (MICs 2-8 mg/L) to polymyxin B and colistin (MICs 0.5-8 mg/L) against a panel of gram-negative clinical isolates of Acinetobacter baumannii, Klebsiella pneumoniae and Pseudomonas aeruginosa...
November 11, 2017: Sensors
https://www.readbyqxmd.com/read/29133838/fungal-networks-serve-as-novel-ecological-routes-for-enrichment-and-dissemination-of-antibiotic-resistance-genes-as-exhibited-by-microcosm-experiments
#17
Rashid Nazir, Ju-Pei Shen, Jun-Tao Wang, Hang-Wei Hu, Ji-Zheng He
Antibiotic resistance genes (ARGs) in the environment and their subsequent acquisition by clinically important microorganisms are a serious concern. However, the spread of environmental ARGs remain largely unknown. We report, for the first time, the involvement of soil fungi in the distribution of bacteria with ARGs via soil microcosms. qPCR assay detected unique ARGs specifically found in the mycosphere of different fungi. Interestingly, the taxonomically and ecologically different fungi exerted different selection pressures on ARGs originating from the same source...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29133814/structural-remodeling-and-oligomerization-of-human-cathelicidin-on-membranes-suggest-fibril-like-structures-as-active-species
#18
Enea Sancho-Vaello, Patrice François, Eve-Julie Bonetti, Hauke Lilie, Sebastian Finger, Fernando Gil-Ortiz, David Gil-Carton, Kornelius Zeth
Antimicrobial peptides as part of the mammalian innate immune system target and remove major bacterial pathogens, often through irreversible damage of their cellular membranes. To explore the mechanism by which the important cathelicidin peptide LL-37 of the human innate immune system interacts with membranes, we performed biochemical, biophysical and structural studies. The crystal structure of LL-37 displays dimers of anti-parallel helices and the formation of amphipathic surfaces. Peptide-detergent interactions introduce remodeling of this structure after occupation of defined hydrophobic sites at the dimer interface...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29133802/a-conformational-switch-in-initiation-factor-2-controls-the-fidelity-of-translation-initiation-in-bacteria
#19
Kelvin Caban, Michael Pavlov, Måns Ehrenberg, Ruben L Gonzalez
Initiation factor (IF) 2 controls the fidelity of translation initiation by selectively increasing the rate of 50S ribosomal subunit joining to 30S initiation complexes (ICs) that carry an N-formyl-methionyl-tRNA (fMet-tRNA(fMet)). Previous studies suggest that rapid 50S subunit joining involves a GTP- and fMet-tRNA(fMet)-dependent "activation" of IF2, but a lack of data on the structure and conformational dynamics of 30S IC-bound IF2 has precluded a mechanistic understanding of this process. Here, using an IF2-tRNA single-molecule fluorescence resonance energy transfer signal, we directly observe the conformational switch that is associated with IF2 activation within 30S ICs that lack IF3...
November 14, 2017: Nature Communications
https://www.readbyqxmd.com/read/29133557/a-novel-mechanism-of-inactivating-antibacterial-nitro-compounds-in-the-human-pathogen-staphylococcus-aureus-by-overexpression-of-a-nadh-dependent-flavin-nitroreductase
#20
Ebaa M El-Hossary, Konrad U Förstner, Patrice François, Damien Baud, Karin Streker, Jacques Schrenzel, Knut Ohlsen, Ulrike Holzgrabe
Recently, the nitro substituted bisquaternary bisnaphthalimides were reported to have substantial anti-infective activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). Here, we selected resistant S. aureus clones by cultivation in increasing concentrations of the most active compound MT02. Interestingly, MT02 resistant variants induced a diffusible red color of the broth. Chromatographic and spectroscopic investigations revealed a stepwise reduction of the bisquaternary bisnaphthalimides̀ nitro groups to amino groups...
November 13, 2017: Antimicrobial Agents and Chemotherapy
keyword
keyword
59590
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"