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https://www.readbyqxmd.com/read/29332216/characteristics-of-arg-carrying-plasmidome-in-the-cultivable-microbial-community-from-wastewater-treatment-system-under-high-oxytetracycline-concentration
#1
Yanhong Shi, Hong Zhang, Zhe Tian, Min Yang, Yu Zhang
Studies on antibiotic production wastewater have shown that even a single antibiotic can select for multidrug resistant bacteria in aquatic environments. It is speculated that plasmids are an important mechanism of multidrug resistance (MDR) under high concentrations of antibiotics. Herein, two metagenomic libraries were constructed with plasmid DNA extracted from cultivable microbial communities in a biological wastewater treatment reactor supplemented with 0 (CONTROL) or 25 mg/L of oxytetracycline (OTC-25)...
January 13, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29331783/comparative-study-of-novel-in-situ-decorated-porous-chitosan-selenium-scaffolds-and-porous-chitosan-silver-scaffolds-towards-antimicrobial-wound-dressing-application
#2
Dhee P Biswas, Neil M O'Brien-Simpson, Eric C Reynolds, Andrea J O'Connor, Phong A Tran
Dermal defects caused by trauma or disease are challenging to treat due to difficult-to-treat infections that impair wound healing. Due to the widespread emergence of drug-resistant bacteria and dwindling discoveries of new antibiotics, there is currently an urgent need to introduce novel antimicrobials effective against antibiotic-resistant bacteria without causing damage to host tissues. As selenium (Se) and silver (Ag) are known for their antimicrobial properties, we investigated the separate loading of these materials into porous chitosan/PVA (CS) scaffolds through a simple in situ deposition method to create two distinct wound dressing materials (CS-Se and CS-Ag)...
January 5, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29331725/bivo4-n-rgo-nano-composites-as-highly-efficient-visible-active-photocatalyst-for-the-degradation-of-dyes-and-antibiotics-in-eco-system
#3
Brindha Appavu, Sivakumar Thiripuranthagan, Sudhakar Ranganathan, Elangovan Erusappan, Kathiravan Kannan
Herein, we report the synthesis of novel nitrogen doped reduced graphene oxide/ BiVO4 photo catalyst by single step hydrothermal method. The physicochemical properties of the catalysts were characterized using XRD, N2 adsorption-desorption, Raman, XPS, SEM TEM, DRS-UV and EIS techniques. The synthesized catalysts were tested for their catalytic activity in the photo degradation of some harmful textile dyes (methylene blue & congo red) and antibiotics (metronidazole and chloramphenicol) under visible light irradiation...
January 10, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29331155/performance-of-a-novel-antipseudomonal-antibiotic-consumption-metric-among-academic-medical-centers-in-the-united-states
#4
John Daniel Markley, Amy L Pakyz, Roy T Sabo, Gonzalo Bearman, Samuel F Hohmann, Michael P Stevens
A metric was developed to identify hospital proportion of carbapenem consumption (PoCC) among antipseudomonal antibiotics. The PoCC varied significantly among academic medical centers by Census Bureau geographic division after adjusting for patient mix. This metric may be useful in identifying disproportionate carbapenem use and potential carbapenem overuse. Infect Control Hosp Epidemiol 2018;1-4.
January 14, 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29330182/fluorescence-recovery-allows-the-implementation-of-a-fluorescence-reporter-gene-platform-applicable-for-the-detection-and-quantification-of-horizontal-gene-transfer-in-anoxic-environments
#5
Rafael Pinilla, Leise Riber, Søren J Sørensen
The study of horizontal gene transfer (HGT) in microbial communities has been revolutionized by significant advances in cultivation-independent methods based on fluorescence reporter gene technologies. Recently, the combination of these novel approaches with flow cytometry has presented itself as one of the most powerful tools to study the spread of mobile genetic elements (MGEs) in the environment. However, the use of fluorescent markers like green fluorescent protein (GFP) and mCherry is limited by environmental constraints that affect the correct maturation of their fluorophores, such as oxygen availability and pH levels...
January 12, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29329393/tgf-%C3%AE-mediated-nadph-oxidase-4-dependent-oxidative-stress-promotes-colistin-induced-acute-kidney-injury
#6
Bo Young Jeong, Se-Ra Park, Sungkwon Cho, Seong-Lan Yu, Hoi Young Lee, Chang Gyo Park, Jaeku Kang, Da-Young Jung, Moon Hyang Park, Won-Min Hwang, Sung-Ro Yun, Ju-Young Jung, Se-Hee Yoon
Background: Colistin (polymyxin E) is an important constituent of the polymyxin class of cationic polypeptide antibiotics. Intrarenal oxidative stress can contribute to colistin-induced nephrotoxicity. Nicotinamide adenine dinucleotide 3-phosphate oxidases (Noxs) are important sources of reactive oxygen species. Among the various types of Noxs, Nox4 is predominantly expressed in the kidney. Objectives: We investigated the role of Nox4 and benefit of Nox4 inhibition in colistin-induced acute kidney injury using in vivo and in vitro models...
January 9, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29329277/synthesis-structural-characterization-antimicrobial-activity-and-in-vitro-biocompatibility-of-new-unsaturated-carboxylate-complexes-with-2-2-bipyridine
#7
Gina Vasile Scăețeanu, Mariana Carmen Chifiriuc, Coralia Bleotu, Crina Kamerzan, Luminiţa Măruţescu, Constantin G Daniliuc, Cătălin Maxim, Larisa Calu, Rodica Olar, Mihaela Badea
The synthesis, structural characterization, cytotoxicity, and antimicrobial properties of four new complexes formed by employing acrylate anion and 2,2'-bipyridine are reported herein. X-ray crystallography revealed the trinuclear nature of [Mn₃(2,2'-bipy)₂(C₃H₃O₂)₆] (1), meanwhile complexes with general formula [M(2,2'-bipy)(C₃H₃O₂)₂(H₂O)x]∙yH₂O ((2) M: Ni, x = 1, y = 0; (3) M: Cu, x = 1, y = 0; (4) M: Zn, x = 0, y = 1; 2,2'-bipy: 2,2'-bipyridine; C₃H₃O₂: acrylate anion) were shown to be mononuclear...
January 12, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29328999/discovery-of-novel-piperonyl-derivatives-as-diapophytoene-desaturase-inhibitors-for-the-treatment-of-methicillin-vancomycin-and-linezolid-resistant-staphylococcus-aureus-infections
#8
Hanwen Wei, Fei Mao, Shuaishuai Ni, Feifei Chen, Baoli Li, Xiaoxia Qiu, Linghao Hu, Manjiong Wang, Xinyu Zheng, Jin Zhu, Lefu Lan, Jian Li
Inhibition of S. aureus diapophytoene desaturase (CrtN) could serve as an alternative approach for addressing the tricky antibiotic resistance by blocking the biosynthesis of carotenoid pigment which shields the bacterium from host oxidant killing. In this study, we designed and synthesized 44 derivatives with piperonyl scaffold targeting CrtN and the structure-activity relationships (SARs) were examined extensively to bring out the discovery of 21b with potent efficacy and better hERG safety profile compared to the first class CrtN inhibitor benzocycloalkane derivative 2...
December 29, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29326825/staphylococcal-scalded-skin-syndrome-a-pediatric-dermatology-case-report
#9
Girish Gulab Meshram, Neeraj Kaur, Kanwaljeet Singh Hura
Staphylococcal scalded skin syndrome is a condition which predominantly affects children and causes a spectrum of skin lesions. We present a case of a 2-month-old infant with complaints of fever and fragile blisters over the body. The mucosal areas were spared. The diagnosis of staphylococcal scalded skin syndrome was reached on clinical grounds and culture report. The patient responded well to the treatment, which included an antibiotic (cloxacillin), an analgesic (paracetamol), and hydration with intravenous fluids...
2018: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29326499/in-search-of-a-novel-substitute-clinical-and-radiological-success-of-lesion-sterilization-and-tissue-repair-with-modified-3mix-mp-antibiotic-paste-and-conventional-pulpectomy-for-primary-molars-with-pulp-involvement-with-18-months-follow-up
#10
Divya Doneria, Seema Thakur, Parul Singhal, Deepak Chauhan, Karunakar Keshav, Anika Uppal
Objectives: The aim of this study was to evaluate the clinical and radiographic success of zinc oxide (ZnO)-ozonated oil, modified 3Mix antibiotic paste, and vitapex in the treatment of primary molars requiring pulpectomy. Methods: Sixty-four primary molars of forty-three healthy children aged between 4 and 8 years with primary molars requiring root canal procedure were treated with ZnO-ozonated oil, modified 3Mix-MP antibiotic paste, and vitapex. Clinical follow up was done at 1, 6,12 months and 18 months while radiographical follow-up was done at 6,12 and 18 months, respectively...
October 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29326226/draft-genome-sequence-of-chryseobacterium-mucoviscidosis-sp-nov-strain-vt16-26-isolated-from-the-bronchoalveolar-lavage-fluid-of-a-patient-with-cystic-fibrosis
#11
George Tetz, Victor Tetz
We report here the draft genome sequence of Chryseobacterium mucoviscidosis VT16-26, a novel bacterium isolated from the lungs of a patient with cystic fibrosis. The genome was composed of 4,403,956 bp and had 36.2% G+C content. We detected 4,048 genes with predicted protein-coding functions, including those associated with antibiotic resistance and virulence.
January 11, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29325735/whole-transcriptome-analysis-reveals-potential-novel-mechanisms-of-low-level-linezolid-resistance-in-enterococcus-faecalis
#12
Ruoyi Hua, Yun Xia, Wenyao Wu, Jia Yan, Mi Yang
Linezolid is an oxazolidinone antibiotic commonly used to treat serious infections caused by vancomycin-resistant enterococcus. Recently, low-level linezolid resistant Enterococcus faecalis strains have emerged worldwide, but the resistant mechanisms remain undefined. Whole-transcriptome profiling was performed on an E. faecalis strain P10748 with low-level linezolid resistance in comparison with a linezolid-susceptible strain 3138 and the standard control strain ATCC29212. The functions of differentially expressed genes (DEGs) were predicted, with some DEGs potentially involved in drug resistance were validated by PCR and quantitative PCR (qPCR)...
January 8, 2018: Gene
https://www.readbyqxmd.com/read/29324795/nanodiamonds-facilitate-killing-of-intracellular-uropathogenic-e-coli-in-an-in-vitro-model-of-urinary-tract-infection-pathogenesis
#13
Janaki Kannan Iyer, Alexia Dickey, Parvaneh Rouhani, Anil Kaul, Nirmal Govindaraju, Raj Narain Singh, Rashmi Kaul
About 25-44% of women will experience at least one episode of recurrent UTI and the causative agent in over 70% of UTI cases is uropathogenic Escherichia coli (UPEC). UPEC cause recurrent UTI by evading the bladder's innate immune system through internalization into the bladder epithelium where antibiotics cannot reach or be effective. Thus, it is important to develop novel therapeutics to eliminate these intracellular pathogens. Nanodiamonds (NDs) are biocompatible nanomaterials that serve as promising candidates for targeted therapeutic applications...
2018: PloS One
https://www.readbyqxmd.com/read/29323139/reverse-micelle-extraction-of-antibiotics-using-an-eco-friendly-sophorolipids-biosurfactant
#14
Sing Chuong Chuo, Norfahana Abd-Talib, Siti Hamidah Mohd-Setapar, Hashim Hassan, Hasmida Mohd Nasir, Akil Ahmad, David Lokhat, Ghulam Md Ashraf
Reverse micelles extraction of erythromycin and amoxicillin were carried out using the novel Sophorolipids biosurfactant. By replacing commonly used chemical surfactants with biosurfactant, reverse micelle extraction can be further improved in terms of environmental friendliness and sustainability. A central composite experimental design was used to investigate the effects of solution pH, KCl concentration, and sophorolipids concentration on the reverse micelle extraction of antibiotics. The most significant factor identified during the reverse micelle extraction of both antibiotics is the pH of aqueous solutions...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29322917/identification-of-natural-antimicrobial-peptides-from-bacteria-through-metagenomic-and-metatranscriptomic-analysis-of-high-throughput-transcriptome-data-of-taiwanese-oolong-teas
#15
Kai-Yao Huang, Tzu-Hao Chang, Jhih-Hua Jhong, Yu-Hsiang Chi, Wen-Chi Li, Chien-Lung Chan, K Robert Lai, Tzong-Yi Lee
BACKGROUND: Anti-microbial peptides (AMPs), naturally encoded by genes and generally containing 12-100 amino acids, are crucial components of the innate immune system and can protect the host from various pathogenic bacteria and viruses. In recent years, the widespread use of antibiotics has resulted in the rapid growth of antibiotic-resistant microorganisms that often induce critical infection and pathogenesis. Recently, the advent of high-throughput technologies has led molecular biology into a data surge in both the amount and scope of data...
December 21, 2017: BMC Systems Biology
https://www.readbyqxmd.com/read/29322649/design-expression-and-characterization-of-the-hybrid-antimicrobial-peptide-t-catesbeianin-1-based-on-fyua
#16
Huihui Xu, Kunyuan Tie, Yang Zhang, Xin Feng, Yuan Cao, Wenyu Han
The overuse of antibiotics has resulted in the emergence of antibiotic-resistant bacteria, which presents an urgent need for new antimicrobial agents. At present, antimicrobial peptides have attracted a great deal of attention from researchers. However, antimicrobial peptides often affect a broad range of microorganisms, including the normal flora in a host organism. In the present study, we designed a novel hybrid antimicrobial peptide, expressed the hybrid peptide, and studied its specific target. The hybrid peptide, named T-catesbeianin-1, which includes the FyuA-binding domain of pesticin and the peptide catesbeianin-1, was designed and expressed in Pichia pastoris X-33...
January 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/29321384/discovery-of-a-novel-fluoroquinolone-antibiotic-candidate-wfq-228-with-potent-antimicrobial-activity-and-the-potential-to-overcome-major-drug-resistance
#17
Tatsuya Hirano, Tomohiko Kinoshita, Daichi Kazamori, Satoshi Inoue, Kouji Nishimura, Asuka Sakurai, Kensuke Ohishi, Yasuhiro Kuramoto, Hirotaka Amano, Akira Yazaki
WFQ-101 with a unique N-1 substituent, 5-amino-4-fluoro-2-(hydroxymethyl)phenyl group, was selected as a lead compound through combination screening based on antimicrobial activity and the efflux index against quinolone-resistant (QR) Pseudomonas aeruginosa (P. aeruginosa). Through structural optimization, we identified WFQ-228 as a novel fluoroquinolone antibiotic candidate. WFQ-228 had potent and superior activity in comparison to levofloxacin (LVX) and ciprofloxacin (CIP) against clinical isolates of P. aeruginosa, Escherichia coli and Acinetobacter baumannii, including QR strains...
January 11, 2018: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29321257/the-antimicrobial-peptide-saap-148-combats-drug-resistant-bacteria-and-biofilms
#18
Anna de Breij, Martijn Riool, Robert A Cordfunke, Nermina Malanovic, Leonie de Boer, Roman I Koning, Elisabeth Ravensbergen, Marnix Franken, Tobias van der Heijde, Bouke K Boekema, Paulus H S Kwakman, Niels Kamp, Abdelouahab El Ghalbzouri, Karl Lohner, Sebastian A J Zaat, Jan W Drijfhout, Peter H Nibbering
Development of novel antimicrobial agents is a top priority in the fight against multidrug-resistant (MDR) and persistent bacteria. We developed a panel of synthetic antimicrobial and antibiofilm peptides (SAAPs) with enhanced antimicrobial activities compared to the parent peptide, human antimicrobial peptide LL-37. Our lead peptide SAAP-148 was more efficient in killing bacteria under physiological conditions in vitro than many known preclinical- and clinical-phase antimicrobial peptides. SAAP-148 killed MDR pathogens without inducing resistance, prevented biofilm formation, and eliminated established biofilms and persister cells...
January 10, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29320762/corrected-and-republished-from-identification-of-peptidoglycan-hydrolase-constructs-with-synergistic-staphylolytic-activity-in-cow-s-milk
#19
Carolin T Verbree, Steven M Dätwyler, Susanne Meile, Fritz Eichenseher, David M Donovan, Martin J Loessner, Mathias Schmelcher
Peptidoglycan hydrolases (PGHs) have been suggested as novel therapeutics for the treatment of bovine mastitis. However, activity in the presence of cow's milk is an important requirement for drugs administered into the bovine udder. We have used a microtiter plate-based protocol to screen a library of >170 recombinant PGHs, including engineered bacteriophage endolysins, for enzymes with activity against Staphylococcus aureus in milk. Eight suitable PGH constructs were identified by this approach, and their efficacies against S...
January 1, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29319470/coupling-next-generation-sequencing-to-dominant-positive-screens-for-finding-antibiotic-cellular-targets-and-resistance-mechanisms-in-escherichia-coli
#20
Hélène Gingras, Bédis Dridi, Philippe Leprohon, Marc Ouellette
In order to expedite the discovery of genes coding for either drug targets or antibiotic resistance, we have developed a functional genomic strategy termed Plas-Seq. This technique involves coupling a multicopy suppressor library to next-generation sequencing. We generated an Escherichia coli plasmid genomic library that was transformed into E. coli. These transformants were selected step by step using 0.25× to 2× minimum inhibitory concentrations for ceftriaxone, gentamicin, levofloxacin, tetracycline or trimethoprim...
January 10, 2018: Microbial Genomics
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