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https://www.readbyqxmd.com/read/29778048/pathogens-constancy-harbinger-of-nosocomial-infection-cum-identification-of-resistant-genes-and-drug-designing
#1
Sana Farooq Ahmad, Ibrar Khan, Abdul Wadood, Sadiq Azam, Noor Rehman, Muhammad Waqas, Kashif Bashir, Asaf Ali Khan
Hospitals are the most prominent places for the growth and spread of bacteria which are resistant to the available antibiotics. This antibiotic resistance is due to the over and misuse of antibiotic dosages of a high-density of patient population which are in frequent interaction with inanimate items of the hospitals and the consequent risk of cross infection. Out of 1010 samples of the current study, 510 (50.49%) were culture positive of which 329 (64.5%) were Gram-positive while 181 (35.49%) Gram negative...
April 22, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29777719/purification-and-identification-of-an-actinomycin-d-analogue-from-actinomycetes-associated-with-ganoderma-applanatum-via-magnetic-molecularly-imprinted-polymers-and-tandem-mass-spectrometry
#2
Chang-Gen Li, Bo Yuan, Meng-Meng Dong, Pin-Yu Zhou, Yu-Xin Hao, Ying-Ying Sun, Meng-Ke Xu, Dan Li, Guo-Yin Kai, Ji-Hong Jiang
Actinomycetes are main producers of antibiotics and targeted screening could improve the efficiency of discovering new drugs. This study describes, for the first time, the isolation of endophytic actinomycetes from the macrofungus Ganoderma applanatum. To increase the efficiency of screening, novel actinomycin D (Act D) molecularly-imprinted polymers were adsorbed to the surface of Fe3 O4 @SiO2 magnetic microspheres (MMIPs) and using in the isolation. A monolithic column prepared with magnetic molecularly imprinted polymers was employed to adsorb actinomycin D and its analogues for selective analysis and identification via MS/MS spectroscopy...
May 16, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29775822/nanocomposite-thin-films-ag-0-np-tio-2-in-the-efficient-removal-of-micro-pollutants-from-aqueous-solutions-a-case-study-of-tetracycline-and-sulfamethoxazole-removal
#3
Alka Tiwari, Alok Shukla, Lalliansanga, Diwakar Tiwari, Seung Mok Lee
The aim of this communication is to synthesize novel Nanocomposite thin film materials (Ag0 (NP)/TiO2 ) using the template process. Surface morphology of materials was obtained by the Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM) analyses. The presence of doped Ag-nanoparticles was confirmed by the TEM images along with the SEM-EDX analyses. The Atomic Force Microscopic images were demonstrated the surface roughness and thickness of Nanocomposite thin films. X-ray diffraction analysis confirmed that TiO2 was predominantly present to its anatase mineral phase...
May 15, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29775296/incorporation-of-a-theranostic-two-tone-luminescent-silver-complex-into-biocompatible-agar-hydrogel-composite-for-the-eradication-of-eskape-pathogens-in-a-skin-and-soft-tissue-infection-model
#4
Miguel N Pinto, Jorge Martinez-Gonzalez, Indranil Chakraborty, Pradip K Mascharak
Microbial invasion and colonization of the skin and underlying soft tissues are among the most common types of infections, becoming increasingly prevalent in hospital settings. Systemic antibiotic chemotherapies are now extremely limited due to emergence of drug-resistant Gram-positive and multidrug-resistant Gram-negative bacterial strains. Topical administration of antimicrobials provides an effective route for the treatment of skin and soft tissue infections (SSTIs). Therefore, the development of new and effective materials for the delivery of these agents is of paramount importance...
May 18, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29775283/magnetic-glycol-chitin-based-hydrogel-nanocomposite-for-combined-thermal-and-d-amino-acid-assisted-biofilm-disruption
#5
Eric C Abenojar, Sameera Wickramasinghe, Minseon Ju, Sarika Uppaluri, Alison Klika, Jaiben George, Wael Barsoum, Salvatore J Frangiamore, Carlos A Higuera-Rueda, Anna Cristina S Samia
Bacterial biofilms are highly antibiotic resistant microbial cell associations that lead to chronic infections. Unlike free-floating planktonic bacterial cells, the biofilms are encapsulated in a hardly penetrable extracellular polymeric matrix and, thus, demand innovative approaches for treatment. Recent advancements on the development of gel-nanocomposite systems with tailored therapeutic properties provide promising routes to develop novel antimicrobial agents that can be designed to disrupt and completely eradicate preformed biofilms...
May 18, 2018: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29774758/evaluation-of-natural-bv-as-a-novel-feed-additive-in-fast-growing-broilers
#6
Da Hye Kim, Sang Mi Han, Moung Cheul Keum, Sang Lee, Byoung Ki An, Sang-Rak Lee, Kyung-Woo Lee
1. The present study was designed to evaluate purified bee venom (BV) as an alternative to antibiotics in broiler chickens. The experimental treatment diets were formulated by adding BV into a maize-soybean meal-based diet to give 0, 10, 50, 100, and 500 μg BV per kg of diet. 2. Dietary BV quadratically improved (P<0.05) feed conversion ratio and increased body weight gain at 1-21 days as level in diet increased. Higher BV levels lowered relative weight of spleen (linear and quadratic, P<0.05), bursa of Fabricius (quadratic, P<0...
May 18, 2018: British Poultry Science
https://www.readbyqxmd.com/read/29774213/a-rapid-growth-independent-antibiotic-resistance-detection-test-by-sybr-green-propidium-iodide-viability-assay
#7
Jie Feng, Rebecca Yee, Shuo Zhang, Lili Tian, Wanliang Shi, Wen-Hong Zhang, Ying Zhang
Antibiotic-resistant bacteria have caused huge concerns and demand innovative approaches for their prompt detection. Current antimicrobial susceptibility tests (AST) rely on the growth of the organisms which takes 1-2 days for fast-growing organisms and several weeks for slow growing organisms. Here, we show for the first time the utility of the SYBR Green I/propidium iodide (PI) viability assay for rapidly identifying antibiotic resistance in less than 30 min for major, antibiotic-resistant, fast-growing bacteria, such as Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae , and Acinetobacter baumannii for bactericidal and bacteriostatic agents and in 16 h for extremely rapid detection of drug resistance for isoniazid and pyrazinamide in slow-growing Mycobacterium tuberculosis ...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29773904/methanol-fixed-fibroblasts-serve-as-feeder-cells-to-maintain-stem-cells-in-the-pluripotent-state-in-vitro
#8
Yahui Ren, Ziyu Ma, Tong Yu, Min Ling, Huayan Wang
Preparation of mouse embryonic fibroblast (MEF) feeder cells to maintain pluripotent stem cells (PSCs) is time consuming and involved in animal issues. Here, we demonstrated a novel method to prepare feeder cells with high efficiency, timesaving, and low costs. MEFs in 3 × 104 cell/cm2 were fixed by methanol for 5 min and air drying for 5 min. Thereafter, the methanol fixed MEF cells (MT-MEF) were able to be used directly to culture PSCs or stored at room temperature for the future usage. PSCs cultured on MT-MEF could be continuously expanded for over 40 passages with the naïve pluripotency...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29773011/antibacterial-activity-of-novel-strains-of-bacteriophages-an-experimental-approach
#9
Muhammad Imran Qadir, Zunera Chauhdary
The evolution of antibiotic resistance in bacteria has increased research in the development of alternative therapies to conventional drugs. In this study, isolated phages were characterized and antibacterial activity was determined by standard agar disc diffusion method. The phages showed maximum propagation at 37°C to 40°C and highest viability at pH 7. Sugars influenced the bacteriophage viability. Sodium chloride decreased the phage propagation. Calcium chloride and magnesium chloride increased the phage propagation up to a certain limit...
2018: Critical Reviews in Eukaryotic Gene Expression
https://www.readbyqxmd.com/read/29772991/reconstruction-plate-based-antibiotic-cement-spacers-clinical-outcomes-and-description-of-technique
#10
Aditya V Maheshwari, Robert Pivec, Roby Abraham, Qais Naziri
The standard of care for chronic deep peri-prosthetic hip infection is a two-stage exchange with placement of a temporary antibiotic cement spacer and treatment with intravenous antibiotics. Several commercially available cement spacer options exist. We report on a novel antibiotic spacer that may be an efficient, cost-effective alternative. Medical records of all patients treated for deep peri-prosthetic hip infection after total hip arthroplasty between 2004 and 2012 were reviewed. Each antibiotic spacer was constructed from a 12- to 16-hole recon plate bent to provide adequate soft tissue tension and a cement ball that matched the acetabulum...
2018: Journal of Long-term Effects of Medical Implants
https://www.readbyqxmd.com/read/29772736/exploring-the-effect-of-phage-therapy-in-preventing-vibrio-anguillarum-infections-in-cod-and-turbot-larvae
#11
Nanna Rørbo, Anita Rønneseth, Panos G Kalatzis, Bastian Barker Rasmussen, Kirsten Engell-Sørensen, Hans Petter Kleppen, Heidrun Inger Wergeland, Lone Gram, Mathias Middelboe
The aquaculture industry is suffering from losses associated with bacterial infections by opportunistic pathogens. Vibrio anguillarum is one of the most important pathogens, causing vibriosis in fish and shellfish cultures leading to high mortalities and economic losses. Bacterial resistance to antibiotics and inefficient vaccination at the larval stage of fish emphasizes the need for novel approaches, and phage therapy for controlling Vibrio pathogens has gained interest in the past few years. In this study, we examined the potential of the broad-host-range phage KVP40 to control four different V...
May 16, 2018: Antibiotics
https://www.readbyqxmd.com/read/29772345/autologous-liquid-platelet-rich-fibrin-a-novel-drug-delivery-system
#12
REVIEW
Richard J Miron, Yufeng Zhang
There is currently widespread interest within the biomaterial field to locally deliver biomolecules for bone and cartilage regeneration. Substantial work to date has focused on the potential role of these biomolecules during the healing process, and the carrier system utilized is a key factor in their effectiveness. Platelet rich fibrin (PRF) is a naturally derived fibrin scaffold that is easily obtained from peripheral blood following centrifugation. Slower centrifugation speeds have led to the commercialization of a liquid formulation (liquid-PRF) resulting in an upper plasma layer composed of liquid fibrinogen/thrombin prior to clot formation that remains in its liquid phase for approximately 15 minutes until injected into bodily tissues...
May 14, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29772229/polybacterial-community-analysis-in-human-conjunctiva-through-16s-rrna-gene-libraries
#13
Deepthi KrishnanNair Geetha, Jayasudha Rajagopalaboopathi, Girish Rameshan Nair, Manikandan Palanisamy, Ram Rammohan, Narendran Venkatapathy, Prabagaran Solai Ramatchandirane
The conjunctival sac of healthy human harbours a variety of microorganisms. When the eye is compromised, an occasional inadvertent spread happens to the adjacent tissue, resulting in bacterial ocular infections. Microbiological investigation of the conjunctival swab is one of the broadly used modality to study the aetiological agent of conjunctiva. However, most of the time such methods yield unsatisfactory results. Hence, the present study intends to identify the bacterial community in human conjunctiva of pre-operative subjects through 16S rRNA gene libraries...
May 14, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29771929/a-gratuitous-%C3%AE-lactamase-inducer-uncovers-hidden-active-site-dynamics-of-the-staphylococcus-aureus-blar1-sensor-domain
#14
Thomas E Frederick, Jeffrey W Peng
Increasing evidence shows that active sites of proteins have non-trivial conformational dynamics. These dynamics include active site residues sampling different local conformations that allow for multiple, and possibly novel, inhibitor binding poses. Yet, active site dynamics garner only marginal attention in most inhibitor design efforts and exert little influence on synthesis strategies. This is partly because synthesis requires a level of atomic structural detail that is frequently missing in current characterizations of conformational dynamics...
2018: PloS One
https://www.readbyqxmd.com/read/29771684/antibiotic-treatment-induced-secondary-iga-deficiency-enhances-susceptibility-to-pseudomonas-aeruginosa-pneumonia
#15
Oliver H Robak, Markus M Heimesaat, Andrey A Kruglov, Sandra Prepens, Justus Ninnemann, Birgitt Gutbier, Katrin Reppe, Hubertus Hochrein, Mark Suter, Carsten J Kirschning, Veena Marathe, Jan Buer, Mathias W Hornef, Markus Schnare, Pascal Schneider, Martin Witzenrath, Stefan Bereswill, Ulrich Steinhoff, Norbert Suttorp, Leif E Sander, Catherine Chaput, Bastian Opitz
Broad-spectrum antibiotics are widely used in patients on intensive care units (ICU), many of which develop hospital-acquired infections with Pseudomonas aeruginosa. Although preceding antimicrobial therapy is known as a major risk factor for P. aeruginosa-induced pneumonia, the underlying mechanisms remain incompletely understood. Here we demonstrate that depletion of the resident microbiota by broad-spectrum antibiotic treatment inhibited TLR-dependent production of a proliferation inducing ligand (APRIL), resulting in a secondary IgA deficiency in the lung in mice and human ICU patients...
May 17, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29771255/return-of-the-tetracyclines-omadacycline-a-novel-aminomethylcycline-antimicrobial
#16
J C Cho, L M Childs-Kean, M T Zmarlicka, M P Crotty
Omadacycline is a novel aminomethylcycline antimicrobial agent that is available in both oral and intravenous formulations. The distinguishing structural characteristics of omadacycline from other tetracyclines allow for its continued antimicrobial activity in the presence of traditional tetracycline resistance mechanisms (efflux pumps and ribosomal protection proteins). Omadacycline has been found to have potent activity against antibiotic-resistant pathogens including methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus, extended spectrum beta-lactamase-producing Escherichia coli and multidrug-resistant Streptococcus pneumoniae...
March 2018: Drugs of Today
https://www.readbyqxmd.com/read/29771109/the-therapeutic-pipeline-for-pseudomonas-aeruginosa-infections
#17
Lori L Burrows
Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen, designated by the World Health Organization as a critical priority for development of new therapeutics due to high levels of intrinsic and acquired antibiotic resistance. Other challenges include its versatility (it can persist in the environment and most strains are capable of causing disease in compromised hosts), robust efflux mechanisms that limit drug penetration, and the propensity to form antimicrobial-tolerant biofilms. Novel therapeutics in development to prevent or treat P...
May 17, 2018: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29769016/whole-genome-sequencing-data-of-1110-mycobacterium-tuberculosis-isolates-identifies-insertions-and-deletions-associated-with-drug-resistance
#18
Xi Zeng, Jamie Sui-Lam Kwok, Kevin Yi Yang, Kenneth Siu-Sing Leung, Mai Shi, Zhiyuan Yang, Wing-Cheong Yam, Stephen Kwok-Wing Tsui
BACKGROUND: Drug resistance in Mycobacterium tuberculosis (MTB) is one of the major challenges in tuberculosis (TB) treatment. However, known mutations cannot explain all of the cases of resistance and little research has focused on the relationship between insertions / deletions (indels) and drug resistance. RESULTS: Here, we retrieved whole genome sequencing data of 743 drug-resistant MTB strains and 367 pan-susceptible strains from TB patients from the public domain to identify novel genomic markers of drug resistance...
May 16, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29768720/bis-cyclic-guanidine-as-a-novel-class-of-compounds-potent-against-clostridium-difficile
#19
Chunhui Li, Peng Teng, Zhong Peng, Peng Sang, Xingmin Sun, Jianfeng Cai
Clostridium difficile infection (CDI) symptoms range from diarrhea to severe toxic megacolon and even death. Due to its rapid acquisition of resistance, C. difficile is listed as an urgent antibiotic-resistant threat, and has surpassed methicillin-resistant Staphylococcus aureus (MRSA) as the most common hospital-acquired infections in the USA. To combat the pathogen, the new structural class of pseudo peptides that exhibit antimicrobial activities could play an important role. Herein, we report that bis-cyclic guanidine compounds that exhibit potent antibacterial activity against C...
May 16, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29767565/medical-management-of-deep-ulcerative-keratitis-in-cats-13-cases
#20
Michelle G Martin de Bustamante, Kathryn L Good, Brian C Leonard, Steven R Hollingsworth, Sydney G Edwards, Kelly E Knickelbein, Ann E Cooper, Sara M Thomasy, David J Maggs
Case series summary Described are 13 cats diagnosed with deep ulcerative keratitis and successfully managed medically without grafting procedures. Typical treatment involved frequent topical application of serum and antibiotics (usually a fluoroquinolone and a cephalosporin). Seven cats also received systemic antibiotics. Analgesia was achieved using various combinations of topical atropine and systemic buprenorphine, robenacoxib or corticosteroids. Six cats were hospitalized for a median (range) period of 2...
May 1, 2018: Journal of Feline Medicine and Surgery
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