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https://www.readbyqxmd.com/read/28431981/ventricular-assist-device-elicits-serum-natural-igg-that-correlates-with-the-development-of-primary-graft-dysfunction-following-heart-transplantation
#1
Sarah B See, Kevin J Clerkin, Peter J Kennel, Feifan Zhang, Matthew P Weber, Kortney J Rogers, Debanjana Chatterjee, Elena R Vasilescu, George Vlad, Yoshifumi Naka, Susan W Restaino, Maryjane A Farr, Veli K Topkara, Paolo C Colombo, Donna M Mancini, P Christian Schulze, Bruce Levin, Emmanuel Zorn
BACKGROUND: Pre-transplant sensitization is a limiting factor in solid-organ transplantation. In heart transplants, ventricular assist device (VAD) implantation has been associated with sensitization to human leukocyte antigens (HLA). The effect of VAD on non-HLA antibodies is unclear. We have previously shown that polyreactive natural antibodies (Nabs) contribute to pre-sensitization in kidney allograft recipients. Here we assessed generation of Nabs after VAD implantation in pre-transplant sera and examined their contribution to cardiac allograft outcome...
March 24, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28431036/effects-of-delay-duration-on-the-wms-logical-memory-performance-of-older-adults-with-probable-alzheimer-s-disease-probable-vascular-dementia-and-normal-cognition
#2
Valencia Montgomery, Katie Harris, Anthony Stabler, Lisa H Lu
Objective: To examine how the duration of time delay between Wechsler Memory Scale (WMS) Logical Memory I and Logical Memory II (LM) affected participants' recall performance. Method: There are 46,146 total Logical Memory administrations to participants diagnosed with either Alzheimer's disease (AD), vascular dementia (VaD), or normal cognition in the National Alzheimer's Disease Coordinating Center's Uniform Data Set. Results: Only 50% of the sample was administered the standard 20-35 min of delay as specified by WMS-R and WMS-III...
May 1, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28430305/turbulence-measurements-in-an-axial-rotary-blood-pump-with-laser-doppler-velocimetry
#3
Chan Y Schüle, Klaus Affeld, Max Kossatz, Christian O Paschereit, Ulrich Kertzscher
BACKGROUND: The implantation of rotary blood pumps as ventricular assist devices (VADs) has become a viable therapy for quite a number of patients with end-stage heart failure. However, these rotary blood pumps cause adverse events that are related to blood trauma. It is currently believed that turbulence in the pump flow plays a significant role. But turbulence has not been measured to date because there is no optical access to the flow space in rotary blood pumps because of their opaque casings...
April 18, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28430290/frequency-and-topography-of-small-cerebrovascular-lesions-in-vascular-and-in-mixed-dementia-a-post-mortem-7-tesla-magnetic-resonance-imaging-study-with-neuropathological-correlates
#4
Jacques De Reuck, Florent Auger, Nicolas Durieux, Vincent Deramecourt, Claude-Alain Maurage, Charlotte Cordonnier, Florence Pasquier, Didier Leys, Regis Bordet
<i><b>Introduction</b>: Mixed dementia (MixD) refers to a combination of definite Alzheimer's disease (AD) and vascular encephalopathy. The existence of a "pure" type of vascular dementia (VaD) is controversial. There is a need to find magnetic resonance imaging (MRI) characteristics allowing the distinction between VaD and MixD. The present post-mortem 7.0-tesla MRI compares the frequency or severity and the topography of the small cerebrovascular lesions in brains of patients with VaD and with MixD...
2017: Folia Neuropathologica
https://www.readbyqxmd.com/read/28424272/trends-in-dementia-prevalence-incidence-and-survival-rate-in-a-japanese-community
#5
Tomoyuki Ohara, Jun Hata, Daigo Yoshida, Naoko Mukai, Masaharu Nagata, Toru Iwaki, Takanari Kitazono, Shigenobu Kanba, Yutaka Kiyohara, Toshiharu Ninomiya
OBJECTIVE: To investigate secular trends in the prevalence, incidence, and survival rate of dementia in a Japanese elderly population in a comprehensive manner. METHODS: Five cross-sectional surveys of dementia were conducted among residents of a Japanese community, aged ≥65 years, in 1985, 1992, 1998, 2005, and 2012. We also established 2 cohorts consisting of the residents of this age group without dementia in 1988 (n = 803) and 2002 (n = 1,231), and each was followed for 10 years...
April 19, 2017: Neurology
https://www.readbyqxmd.com/read/28423628/benzyl-isothiocyanate-induces-reactive-oxygen-species-initiated-autophagy-and-apoptosis-in-human-prostate-cancer-cells
#6
Ji-Fan Lin, Te-Fu Tsai, Shan-Che Yang, Yi-Chia Lin, Hung-En Chen, Kuang-Yu Chou, Thomas I-Sheng Hwang
Benzyl isothiocyanate (BITC) in cruciferous plants, which are part of the human diet, has been shown to induce apoptosis in various types of cancer. In this study, we show that BITC effectively suppresses the growth of cultured human prostate cancer cells (CRW-22Rv1 and PC3) by causing mitochondrial membrane potential loss, caspase 3/7 activation and DNA fragmentation. Furthermore, BITC induces ROS generation in these cells. The induction of apoptosis by BITC was significantly attenuated in the presence of N-acetylcysteine (NAC) and catalase (CAT), well-studied ROS scavengers...
March 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28421328/association-of-adiponectin-leptin-and-resistin-with-inflammatory-markers-and-obesity-in-dementia
#7
Małgorzata Bednarska-Makaruk, Ałła Graban, Anna Wiśniewska, Wanda Łojkowska, Anna Bochyńska, Magdalena Gugała-Iwaniuk, Ksenia Sławińska, Agnieszka Ługowska, Danuta Ryglewicz, Hanna Wehr
The aim of the study was to determine the role of adiponectin, leptin and resistin in various types of dementia and to investigate their association with inflammatory markers, insulin resistance and abdominal obesity. In 205 patients with dementia [89 with Alzheimer's disease (AD), 47 with vascular dementia (VaD), 69 with mixed dementia (MD)], 113 persons with mild cognitive impairment and in 107 controls serum adiponectin, leptin and resistin levels, pro-inflammatory [interleukin-6 (IL-6), C-reactive protein (hsCRP) and chitotriosidase] and anti-inflammatory (25-OH vitamin D, HDL-cholesterol and paraoxonase 1) markers, as well as glucose metabolism parameters (glucose, insulin and HOMA-IR) were determined...
April 18, 2017: Biogerontology
https://www.readbyqxmd.com/read/28414098/cytosolic-calcium-mediates-rip1-rip3-complex-dependent-necroptosis-through-jnk-activation-and-mitochondrial-ros-production-in-human-colon-cancer-cells
#8
Wen Sun, Xiaxia Wu, Hongwei Gao, Jie Yu, Wenwen Zhao, Jin-Jian Lu, Jinhua Wang, Guanhua Du, Xiuping Chen
Necroptosis is a form of programmed necrosis mediated by signaling complexes with receptor-interacting protein 1 (RIP1) and RIP3 kinases as the main mediators. However, the underlying execution pathways of this phenomenon have yet to be elucidated in detail. In this study, a RIP1/RIP3 complex was formed in 2-methoxy-6-acetyl-7-methyljuglone (MAM)-treated HCT116 and HT29 colon cancer cells. With this formation, mitochondrial reactive oxygen species (ROS) levels increased, mitochondrial depolarization occurred, and ATP concentrations decreased...
April 14, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28412946/big-data-and-data-repurposing-using-existing-data-to-answer-new-questions-in-vascular-dementia-research
#9
Fergus N Doubal, Myzoon Ali, G David Batty, Andreas Charidimou, Maria Eriksdotter, Martin Hofmann-Apitius, Yun-Hee Kim, Deborah A Levine, Gillian Mead, Hermann A M Mucke, Craig W Ritchie, Charlotte J Roberts, Tom C Russ, Robert Stewart, William Whiteley, Terence J Quinn
INTRODUCTION: Traditional approaches to clinical research have, as yet, failed to provide effective treatments for vascular dementia (VaD). Novel approaches to collation and synthesis of data may allow for time and cost efficient hypothesis generating and testing. These approaches may have particular utility in helping us understand and treat a complex condition such as VaD. METHODS: We present an overview of new uses for existing data to progress VaD research. The overview is the result of consultation with various stakeholders, focused literature review and learning from the group's experience of successful approaches to data repurposing...
April 17, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28405348/mental-status-assessment-of-disaster-relief-personnel-by-vocal-affect-display-based-on-voice-emotion-recognition
#10
Shunji Mitsuyoshi, Mitsuteru Nakamura, Yasuhiro Omiya, Shuji Shinohara, Naoki Hagiwara, Shinichi Tokuno
BACKGROUND: Disaster relief personnel tend to be exposed to excessive stress, which can be a cause of mental disorders. To prevent from mental disorders, frequent assessment of mental status is important. This pilot study aimed to examine feasibility of stress assessment using vocal affect display (VAD) indices as calculated by our proposed algorithms in a situation of comparison between different durations of stay in stricken area as disaster relief operation, which is an environment highly likely to induce stress...
2017: Disaster and Military Medicine
https://www.readbyqxmd.com/read/28403286/nursing-care-protocol-for-patients-with-a-ventricular-assist-device
#11
Regimar Carla Machado, Purificación Gironés, Andressa Rodrigues de Souza, Rita Simone Lopes Moreira, Camila Bomfim von Jakitsch, João Nelson Rodrigues Branco
OBJECTIVE: to develop and validate a nursing care protocol for patients with a ventricular assist device (VAD). METHOD: descriptive study, with a quantitative approach, for an instrument's methodological validation. Three stages were conducted: development of the instrument; protocol content validation according to the Delphi technique, and agreement among experts and the scientific literature. RESULTS: based on the content validation, a care protocol for patients with a VAD was created and assessed by Spanish experts...
April 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28396364/novel-indole-based-tambjamine-analogues-induce-apoptotic-lung-cancer-cell-death-through-p38-mitogen-activated-protein-kinase-activation
#12
Pilar Manuel-Manresa, Luís Korrodi-Gregório, Elsa Hernando, Alberto Villanueva, David Martínez-García, Ananda M Rodilla, Ricard Ramos, Margarida Fardilha, Juan Moya, Roberto Quesada, Vanessa Soto-Cerrato, Ricardo Perez-Tomas
Lung cancer has become the leading killer cancer worldwide, due to late diagnosis and lack of efficient anticancer drugs. We have recently described novel natural-derived tambjamine analogues that are potent anion transporters capable of disrupting cellular ion balance, inducing acidification of the cytosol and hyperpolarization of cellular plasma membranes. Although these tambjamine analogues were able to compromise cell survival, their molecular mechanism of action remains largely unknown. Herein we characterize the molecular cell responses induced by highly active indole-based tambjamine analogues treatment in lung cancer cells...
April 10, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28396243/mechanical-force-mediated-pathological-cartilage-thinning-is-regulated-by-necroptosis-and-apoptosis
#13
C Zhang, S Lin, T Li, Y Jiang, Z Huang, J Wen, W Cheng, H Li
OBJECTIVE: This study aimed to identify the mechanisms underlying mandibular chondrocyte cell death and cartilage thinning in response to mechanical force. MATERIAL AND METHODS: An in vivo model (compressive mechanical force) and an in vitro model (TNF-α+cycloheximide) were used to induce mandibular chondrocyte necroptosis. Hematoxylin and eosin staining and transmission electron microscopy were used to assess histological and subcellular changes in mandibular chondrocyte...
April 7, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28395539/unlocking-the-box-basic-requirements-for-an-ideal-ventricular-assist-device-controller
#14
Alexander L Medvedev, Jamshid H Karimov, Barry D Kuban, David J Horvath, Nader Moazami, Kiyotaka Fukamachi
A modern ventricular assist device (VAD) system comprises an implantable rotary blood pump and external components located outside the patient's body: a wearable controller connected to the pump via a percutaneous cable, wearable rechargeable batteries, battery charger, alternating- and direct-current power supplies, and a hospital device to control and monitor the system. If the blood pump is the "heart" of a VAD system, the controller is its "brain." The controller drives the pump's electrical motor; varies the pump speed or flow based on user commands or feedback signals; collects, processes, and stores data; performs self-diagnostics; transmits to and receives data from other system components, i...
April 11, 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/28390345/communication-slow-proton-charge-diffusion-in-nanoconfined-water
#15
Tibert H van der Loop, Niklas Ottosson, Thomas Vad, Wiebke F C Sager, Huib J Bakker, Sander Woutersen
We investigate proton-charge mobility in nanoscopic water droplets with tuneable size. We find that the diffusion of confined proton charges causes a dielectric relaxation process with a maximum-loss frequency determined by the diffusion constant. In volumes less than ∼5 nm in diameter, proton-charge diffusion slows down significantly with decreasing size: for diameters <1 nm, the diffusion constant is about 100 times smaller than in bulk water. The low mobility probably results from the more rigid hydrogen-bond network of nanoconfined water, since proton-charge mobility in water relies on collective hydrogen-bond rearrangements...
April 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28386842/vitamin-k2-inhibits-rat-vascular-smooth-muscle-cell-calcification-by-restoring-the-gas6-axl-akt-anti-apoptotic-pathway
#16
Cuiting Qiu, Haijun Zheng, Huiren Tao, Wenjun Yu, Xiaoyu Jiang, Aiqin Li, Hui Jin, Anlin Lv, Huan Li
Vascular calcification is associated with cardiovascular disease as a complication of hypertension, hyperlipidemia, diabetes mellitus, and chronic kidney disease. Vitamin K2 (VK2) delays vascular calcification by an unclear mechanism. Moreover, apoptosis modulates vascular smooth muscle cell (VSMC) calcification. This paper aimed to study VK2-modified VSMC calcification and survival cell signaling mediated by growth arrest-specific gene 6 (Gas6) and its tyrosine kinase receptor Axl. Primary-cultured VSMCs were dose-dependently treated with VK2 in the presence of calcification medium for 8 days, or pre-treated for 1 h with/without the Axl inhibitor R428 (2 μmol/L) or the caspase inhibitor Z-VAD-fmk (20 μmol/L) followed by treatment with VK2 (10 μmol/L) or rmGas6 (200 nmol/L) in calcification medium for 8 days...
April 6, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28383556/synovial-cell-death-is-regulated-by-tnf-%C3%AE-induced-expression-of-b-cell-activating-factor-through-an-erk-dependent-increase-in-hypoxia-inducible-factor-1%C3%AE
#17
Jae-Wook Lee, Jiyoung Lee, Sung Hee Um, Eun-Yi Moon
B-cell activating factor (BAFF) has a role in the maturation and maintenance of B cells and is associated with rheumatoid arthritis (RA). Here, we investigated whether tumor necrosis factor (TNF)-α-induced BAFF expression controls the survival of fibroblast-like synoviocytes (FLS) and whether their survival can be regulated by TNF-α-mediated upregulation of hypoxia-inducible factor (HIF)-1α using MH7A synovial cells transfected with the SV40 T antigen. More TNF-α-treated cells died compared with the control...
April 6, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28382876/assessment-of-risks-posed-to-vad-patients-during-disasters
#18
Katherine J Davis, Genevieve O'Shea, Michael Beach
Ventricular assist devices (VADs) are an Advanced Life Support for patients with heart failure. These patients are particularly vulnerable in the event of a disaster. A hazard vulnerability analysis (HVA) was conducted to determine areas of susceptibility for these patients. Lack of electrical power, limited access to medications and anticoagulation, dehydration, extreme temperature and weather environments, conditions which predispose to infection, and evacuation transport are all identified circumstances that place these patients at an increased risk for harm and death...
April 6, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/28378179/non-progressive-labor-in-the-second-stage-leading-to-vacuum-extraction-is-a-risk-factor-for-recurrent-non-progressive-labor
#19
Avi Harlev, Sarah K Fatool, Ruslan Sergienko, Eyal Sheiner
OBJECTIVE: To address risk factors and perinatal outcomes after vacuum-assisted delivery (VAD) due to non-progressive labor (NPL) 2nd stage, and to assess its impact on the subsequent delivery. METHODS: A retrospective, population-based cohort study was conducted in a tertiary medical center. Maternal characteristics, and maternal and neonatal outcomes of singleton pregnancies that resulted in VAD due to NPL 2nd stage were compared to those that resulted in VAD due to other indications...
April 4, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28375841/a-mock-heart-engineered-with-helical-aramid-fibers-for-in-vitro-cardiovascular-device-testing
#20
So-Hyun Jansen-Park, Po-Lin Hsu, Indra Müller, Ulrich Steinseifer, Dirk Abel, Rüdiger Autschbach, Rolf Rossaint, Thomas Schmitz-Rode
Mock heart circulation loops (MHCLs) serve as in-vitro platforms to investigate the physiological interaction between circulatory systems and cardiovascular devices. A mock heart (MH) engineered with silicone walls and helical aramid fibers, to mimic the complex contraction of a natural heart, has been developed to advance the MHCL previously developed in our group. A mock aorta with an anatomical shape enables the evaluation of a cannulation method for ventricular assist devices (VADs) and investigation of the usage of clinical measurement systems like pressure-volume catheters...
April 1, 2017: Biomedizinische Technik. Biomedical Engineering
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