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https://www.readbyqxmd.com/read/28929512/systematic-design-of-a-magnetically-levitated-brushless-dc-motor-for-a-reversible-rotary-intra-aortic-blood-pump
#1
Yaxin Wang, Thomas G Logan, P Alex Smith, Po-Lin Hsu, William E Cohn, Liping Xu, Richard A McMahon
The IntraVAD is a miniature intra-aortic ventricular assist device (VAD) designed to work in series with the compromised left ventricle. A reverse-rotation control (RRc) mode has been developed to increase myocardial perfusion and reduce ventricular volume. The RRc mode includes forward rotation in systole and reverse rotation in diastole, which requires the IntraVAD to periodically reverse its rotational direction in synchrony with the cardiac cycle. This periodic reversal leads to changes in pressure force over the impeller, which makes the entire system less stable...
September 20, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28921937/ventricular-assist-device-use-in-single-ventricle-congenital-heart-disease
#2
REVIEW
Waldemar F Carlo, Chet R Villa, Ashwin K Lal, David L Morales
As VAD have become an effective therapy for end-stage heart failure, their application in congenital heart disease has increased. Single ventricle congenital heart disease introduces unique physiologic challenges for VAD use. However, with regard to the mixed clinical results presented within this review, we suggest that patient selection, timing of implant, and center experience are all important contributors to outcome. This review focuses on the published experience of VAD use in single ventricle patients and details physiologic challenges and novel approaches in this growing pediatric and adult population...
September 15, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28905043/vascular-parkinsonism-and-vascular-dementia-are-associated-with-an-increased-risk-of-vascular-events-or-death
#3
Jacek Staszewski, Renata Piusińska-Macoch, Bogdan Brodacki, Ewa Skrobowska, Katarzyna Macek, Adam Stępień
INTRODUCTION: The natural course of vascular parkinsonism (VaP) and dementia (VaD) due to cerebral small vessel disease (SVD) is not well known. The aim of this single-center study was to evaluate the long-term risk of vascular events, death and dependency in patients with VaP or VaD and to compare it with patients without cerebrovascular disease but with high atherothrombotic risk. MATERIAL AND METHODS: Seventy-eight consecutive, functionally independent patients with MRI features of SVD and with recently diagnosed VaD (n = 50) and VaP (n = 28) and 55 controls (control group - CG) with high 10-year risk of total cardiovascular disease (SCORE ≥ 5%) were prospectively recruited and followed for 24 months...
2017: Arch Med Sci Atheroscler Dis
https://www.readbyqxmd.com/read/28892004/arenobufagin-induces-apoptotic-cell-death-in-human-non-small-cell-lung-cancer-cells-via-the-noxa-related-pathway
#4
Liang Ma, Yindi Zhu, Sheng Fang, Hongyan Long, Xiang Liu, Zi Liu
Arenobufagin, an active component isolated from the traditional Chinese medicine Chan Su, exhibits anticancer influences in several human malignancies. However, the effects and action mechanisms of arenobufagin on non-small-cell lung cancer (NSCLC) are still unknown. In this study, we reported that arenobufagin acted through activation of Noxa-related pathways and promoted apoptotic cell death in human NSCLC cells. Our results revealed that arenobufagin-induced apoptosis was caspase-dependent, as evidenced by the fact that caspase-9, caspase-3 and poly (ADP-ribose) polymerase (PARP) were cleaved, and pretreatment with a pan-caspase inhibitor Z-VAD-FMK inhibited the pro-apoptosis effect of arenobufagin...
September 11, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28888837/left-ventricular-device-implantation-impacts-on-hospitalisation-rates-length-of-stay-and-out-of-hospital-time
#5
Roslyn Prichard, Louise Kershaw, Stephen Goodall, Patricia Davidson, Phillip Newton, Frederick McNeil, Timothy Homer, Christopher Hayward
BACKGROUND: Widespread application of left ventricular assist devices (LVADs) in advanced heart failure, is limited by costs, and access to technical expertise. Hospitalisation drives both cost and inversely, quality of life - but cross institutional and pre-surgical inpatient length of stay data is missing in the Australian literature. We describe changes in hospitalisation rates, in the year before and after bridge to transplant LVAD therapy and preceding heart transplant (HTX). METHODS: Hospitalisation, Australian refined diagnosis group (ArDRG), and clinical data were assessed for 77/100 consecutive patients listed for heart transplant between July of 2009 and June of 2012...
July 18, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28888521/impact-of-center-left-ventricular-assist%C3%A2-device-volume-on-outcomes%C3%A2-after%C3%A2-implantion-an-intermacs-analysis
#6
Jennifer A Cowger, John M Stulak, Palak Shah, Todd F Dardas, Francis D Pagani, Shannon M Dunlay, Simon Maltais, Keith D Aaronson, Ramesh Singh, Nahush A Mokadam, James K Kirklin, Christopher T Salerno
OBJECTIVES: This study examined patient outcomes after left ventricular assist device (LVAD) implantation across a range of center surgical volumes. BACKGROUND: In order for a center to qualify for reimbursement, Centers for Medicare and Medicaid Services (CMS) requires it to implant ≥10 LVADs or total artificial hearts over a 3-year period. The impact of center LVAD surgical volumes on patient outcomes has not been thoroughly scrutinized. METHODS: Center volumes were provided for 7,416 patients undergoing LVAD implantation who were enrolled in INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support)...
August 30, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28888071/the-effect-of-ventricular-assist-device-associated-biomaterials-on-human-blood-leukocytes
#7
Gemma Radley, Ina Laura Pieper, Catherine A Thornton
Ventricular assist devices (VADs) are an effective bridging or destination therapy for patients with advanced stage heart failure. These devices remain susceptible to adverse events including infection, bleeding, and thrombus; events linked to the foreign body response. Therefore, the biocompatibility of all biomaterials used is crucial to the success of medical devices. Biomaterials common in VADs-DLC: diamond-like carbon coated stainless steel; Sap: single-crystal sapphire; SiN: silicon nitride; Ti: titanium alloy; and ZTA: zirconia-toughened alumina-were tested for their biocompatibility through incubation with whole human blood for 2 h with mild agitation...
September 9, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28885564/relationship-between-the-nutritional-status-of-vitamin-a-per-trimester-of-pregnancy-with-maternal-anthropometry-and-anemia-after-roux-en-y-gastric-bypass
#8
Sabrina Cruz, Andréa Matos, Suelem Pereira da Cruz, Silvia Pereira, Carlos Saboya, Andréa Ramalho
The aim of this study was to compare the nutritional status of vitamin A per trimester of pregnancy, as well as to assess its influence on pre-pregnancy BMI, total gestational weight gain (TGWG) and presence of anemia in women who had previously undergone Roux-en-Y gastric bypass (RYGB). An analytical, longitudinal and retrospective study comprising 30 pregnant women who had previously undergone RYGB was undertaken. In all trimesters of pregnancy, the serum concentrations of retinol, β-carotene, stages of vitamin A deficiency (VAD), night blindness (NB), anemia and anthropometric variables were assessed...
September 8, 2017: Nutrients
https://www.readbyqxmd.com/read/28885501/outcomes-of-abdominal-surgery-in-patients-with-mechanical-ventricular-assist-devices-a-multi-institutional-study
#9
Krystle M Leung, Maria X Kiely, Ashlee Kimbrell, Ammar Asban, Rosemary Kelley, Ronald Bleday, Jennifer S Davids, Nelya Melnitchouk
OBJECTIVE: The aim of this study was to examine the outcomes of elective and emergent abdominal operations performed in end-stage heart failure patients supported with ventricular assist devices (VADs). SUMMARY OF BACKGROUND DATA: With the growing volume of end-stage heart failure patients receiving VADs, an increasing number of these patients require surgery for noncardiac pathology. There is a paucity of studies on the safety of abdominal operations in this population...
September 6, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28885380/use-of-durable-continuous-flow-ventricular-assist-devices-in-patients-on-immunosuppression
#10
Robert A Sorabella, Jiho Han, Veli K Topkara, A Reshad Garan, Melana Yuzefpolskaya, Paolo C Colombo, Koji Takeda, Yoshifumi Naka, Hiroo Takayama
Durable ventricular assist device (VAD) therapy remains an important treatment for end-stage heart failure. Despite advancements in device design, postimplant infectious complications continue to plague this population. In this study, we aim to evaluate the use of durable VAD therapy in patients on active immunosuppression. All patients undergoing durable, continuous-flow VAD placement on active immunosuppression at our center from 2004 to 2012 were included in the analysis (group immunosuppressed [IS]; n = 13)...
September 5, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28884121/contrast-microsphere-destruction-by-a-continuous-flow-ventricular-assist-device-an-in-vitro-evaluation-using-a-mock-circulation-loop
#11
David G Platts, Nicole Bartnikowski, Shaun D Gregory, Gregory M Scalia, John F Fraser
OBJECTIVES: Transthoracic echocardiography (TTE) is fundamental in managing patients supported with ventricular assist devices (VAD). However imaging can be difficult in these patients. Contrast improves image quality but they are hydrodynamically fragile agents. The aim was to assess contrast concentration following passage through a VAD utilising a mock circulation loop (MCL). METHODS: Heartware continuous flow (CF) VAD was incorporated into a MCL. Definity® contrast was infused into the MCL with imaging before and after CF-VAD...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28869130/-onychomadesis-in-an-immunocompetent-adult-patient
#12
H A Eguía Angeles, C O Sotelo García, J Vadæle, H Rasmussen, E A Eguía Angeles
No abstract text is available yet for this article.
August 28, 2017: Semergen
https://www.readbyqxmd.com/read/28869117/microfludic-platforms-for-the-evaluation-of-anti-platelet-agent-efficacy-under-hyper-shear-conditions-associated-with-ventricular-assist-devices
#13
Annalisa Dimasi, Marco Rasponi, Filippo Consolo, Gianfranco B Fiore, Danny Bluestein, Marvin J Slepian, Alberto Redaelli
Thrombus formation is a major adverse event affecting patients implanted with ventricular assist devices (VADs). Despite anti-thrombotic drug administration, thrombotic events remain frequent within the first year post-implantation. Platelet activation (PA) is an essential process underling thrombotic adverse events in VAD systems. Indeed, abnormal shear forces, correlating with specific flow trajectories of VADs, are strong agonists mediating PA. To date, the ability to determine efficacy of anti-platelet (AP) agents under shear stress conditions is limited...
August 28, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28863804/investigation-of-a-gene-signature-to-predict-response-to-immunomodulatory-derivatives-for-patients-with-multiple-myeloma-an-exploratory-retrospective-study-using-microarray-datasets-from-prospective-clinical-trials
#14
Manisha Bhutani, Qing Zhang, Reed Friend, Peter M Voorhees, Lawrence J Druhan, Bart Barlogie, Pieter Sonneveld, Gareth J Morgan, James T Symanowski, Belinda R Avalos, Edward A Copelan, Saad Z Usmani
BACKGROUND: Immunomodulatory derivatives (IMiDs), along with proteasome inhibitors, are key components of treatment regimens for multiple myeloma. Nonetheless, outcomes vary among treated individuals. Drug-specific gene-expression profile (GEP) signatures that aid the prediction of favourable and unfavourable outcomes can provide patients with the most effective therapy for their individual disease. We aimed to develop and validate a gene expression signature to suggest which patients would benefit most from IMiD-based therapies...
September 2017: Lancet Haematology
https://www.readbyqxmd.com/read/28863337/-being-a-ventricular-assist-device-recipient-a-liminal-existence
#15
Holly C Standing, Tim Rapley, Guy A MacGowan, Catherine Exley
Ventricular assist devices (VADs) are playing an increasing role in the management of heart failure. VADs are mechanical circulatory devices that support or replace the function of a failing heart. Currently, VADs are only offered in theUnited Kingdom (UK) to patients waiting for a heart transplant; however, the use of these devices is likely to increase in the near future. Presently, there is a dearth of literature exploring the day-to-day realities of living with a VAD, which will become increasingly important as the role of VADs is increased...
August 19, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28859253/flow-features-and-device-induced-blood-trauma-in-cf-vads-under-a-pulsatile-blood-flow-condition-a-cfd-comparative-study
#16
Zengsheng Chen, Sofen K Jena, Guruprasad A Giridharan, Steven C Koenig, Mark S Slaughter, Bartley P Griffith, Zhongjun J Wu
In this study, the flow features and device-associated blood trauma in four clinical ventricular assist devices (VADs) (two implantable axial VADs, one implantable centrifugal VAD, and one extracorporeal VAD) were computationally analyzed under clinically relevant pulsatile flow conditions. The four VADs were operated at fixed pump speed at a mean rate of 4.5 L/min. Mean pressure difference, wall shear stress (WSS), volume distribution of scalar shear stress (SSS), and shear-induced hemolysis index (HI) were derived from the flow field of each VAD and were compared...
August 31, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28856823/talking-with-caregivers-of-children-living-in-the-community-with-ventricular-assist-devices
#17
Courtney Petruik, Cheryl Mack, Jennifer Conway, Holger Buchholz, Michael van Manen
A VAD is a mechanical pump used to support the functioning of a failing heart. As a pediatric therapy, a VAD is used as a temporary solution for poor heart function, a bridge to transplantation or recovery, or a destination therapy. The goal of this qualitative study was to explore the perspectives of family and professional caregivers of children who are supported by VADs in outpatient settings. Semi-structured interviews were conducted with 22 caregivers of school-aged children discharged home on VAD support...
August 29, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28855402/polycystic-kidney-disease-is-significantly-associated-with-dementia-risk
#18
Tung-Min Yu, Ya-Wen Chuang, Kuo-Ting Sun, Mei-Ching Yu, Shiang-Cheng Kung, Brian K Lee, Shih-Ting Huang, Cheng-Hsu Chen, Cheng-Li Lin, Chia-Hung Kao
OBJECTIVE: Data on the risk of neurodegenerative diseases, including Alzheimer disease (AD) and Parkinson disease (PD), in patients with polycystic kidney disease (PKD) are lacking. METHODS: A total of 4,229 patients who were aged ≥20 years and had received a diagnosis of PKD were included in the PKD cohort. For each PKD case identified, 1 participant aged ≥20 years without a history of PKD, dementia, or PD was selected from the comparison cohort. For each patient with PKD, the corresponding controls were selected 1:1 on the basis of the nearest propensity score calculated using logistic regression...
August 30, 2017: Neurology
https://www.readbyqxmd.com/read/28853178/the-ab-portable-driver-generates-higher-drive-line-pressures-possibly-leading-to-accelerated-hemolysis
#19
Motohiko Goda, Naoto Yabu, Norihisa Tominaga, Daisuke Machida, Yukihisa Isomatsu, Shinichi Suzuki, Manabu Nitta, Naohiro Komura, Naoki Nakayama, Masayoshi Kiyokuni, Teruyasu Sugano, Munetaka Masuda
The AB5000 Circulatory Support System is paracorporeal pulsatile ventricular assist device. The AB Portable Driver is a portable console for this system. We experienced two cases with accelerated hemolysis while receiving support by the AB Portable Driver. The purpose of this study was to clarify the mechanical differences associated with the hemolysis between the AB5000 console and the AB Portable Driver. The mock circulatory system modeled by an AB5000 ventricle and a blood sampling bag of vinyl chloride was run with an AB5000 console or AB Portable Driver...
August 29, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28837200/carboxylate-isosteres-for-caspase-inhibitors-the-acylsulfonamide-case-revisited
#20
Y Adriaenssens, D Jiménez Fernández, L Vande Walle, F Elvas, J Joossens, A Lambeir, K Augustyns, M Lamkanfi, P Van der Veken
As part of an ongoing effort to discover inhibitors of caspase-1 with an optimized selectivity and biopharmaceutical profile, acylsulfonamides were explored as carboxylate isosteres for caspase inhibitors. Acylsulfonamide analogues of the clinically investigated caspase-1 inhibitor VRT-043198 and of the pan-caspase inhibitor Z-VAD-CHO were synthesized. The isostere-containing analogues with an aldehyde warhead had inhibitory potencies comparable to the carboxylate references. In addition, the conformational and tautomeric characteristics of these molecules were determined using (1)H- and (13)C-based NMR...
September 13, 2017: Organic & Biomolecular Chemistry
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