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https://www.readbyqxmd.com/read/29136724/-expert-consensus-for-the-diagnosis-and-treatment-of-patients-with-renal-impairment-of-multiple-myeloma
#1
(no author information available yet)
Renal impairment (RI) is a common complication of multiple myeloma (MM), which is presented as chronic kidney disease (CKD) or acute kidney injury (AKI). The typical pathological feature is cast nephropathy. Presently international system staging (ISS) is used in evaluating MM. Although the classic Durie-Salmon staging system could be still used in clinical practice, it may miss out some patients with renal impairment. For evaluations of RI in MM patients with CKD, it's recommended to assess the estimated glomerular filtration rate (eGFR) by creatinine based formula CKD-epidemiology collaboration (EPI) or modification of diet in renal disease(MDRD) and to stage the renal injuries according to 2013 Kidney Disease Improving Global Outcomes (KDIGO) CKD guidelines...
November 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29135021/diagnostic-accuracy-of-the-chinese-version-of-the-trail-making-test-for-screening-cognitive-impairment
#2
Mingqing Wei, Jing Shi, Ting Li, Jingnian Ni, Xuekai Zhang, Yumeng Li, Shenghua Kang, Fuyun Ma, Hengge Xie, Bin Qin, Dongsheng Fan, Liping Zhang, Yongyan Wang, Jinzhou Tian
BACKGROUND/OBJECTIVES: The Trail-Making Test (TMT), which is commonly used to measure executive function, consists of two components (TMT-A and TMTB). There is a lack of normative TMT data for Chinese elderly adults. This study aimed to evaluate the validity of the TMT in screening for cognitive impairment. DESIGN: 2,294 Chinese-speaking adults aged 50 to 85: 1,026 with normal cognition (NC), 462 with mild cognitive impairment (MCI), 108 with Alzheimer's disease (AD), 113 with vascular mild cognitive impairment (VaMCI), 121 with vascular dementia (VaD), 282 with uncertain types of dementia, and 15 with mixed dementia...
November 14, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29134450/comorbidity-burden-of-dementia-a-hospital-based-retrospective-study-from-2003-to-2012-in-seven-cities-in-china
#3
Qing-Hua Wang, Xin Wang, Xian-Le Bu, Yan Lian, Yang Xiang, Hong-Bo Luo, Hai-Qiang Zou, Jie Pu, Zhong-He Zhou, Xiao-Ping Cui, Qing-Song Wang, Xiang-Qun Shi, Wei Han, Qiang Wu, Hui-Sheng Chen, Hang Lin, Chang-Yue Gao, Li-Li Zhang, Zhi-Qiang Xu, Meng Zhang, Hua-Dong Zhou, Yan-Jiang Wang
Dementia is increasing dramatically and imposes a huge burden on society. To date, there is a lack of data on the health status of patients with dementia in China. In an attempt to investigate the comorbidity burden of dementia patients in China at the national level, we enrolled 2,938 patients with Alzheimer's disease (AD), vascular dementia (VaD), or other types of dementia, who were admitted to tertiary hospitals in seven regions of China from January 2003 to December 2012. The Charlson Comorbidity Index (CCI) was used to evaluate the comorbidity burden of the patients with dementia...
November 13, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/29132931/hybrid-surgical-versus-percutaneous-access-epicardial-ventricular-tachycardia-ablation
#4
Anthony Li, Justin Hayase, Duc Do, Eric Buch, Marmar Vaseghi, Olujimi A Ajijola, Carlos Macias, Yuliya Krokhaleva, Houman Khakpour, Noel G Boyle, Peyman Benharash, Reshma Biniwale, Kalyanam Shivkumar, Jason S Bradfield
BACKGROUND: There is limited experience of surgical epicardial access in the contemporary era of ventricular tachycardia ablation after prior cardiac surgery. OBJECTIVE: To describe our institutional experience with surgical epicardial access, the influence of surgical approach and compare outcomes to a propensity-matched percutaneous epicardial access control group. METHODS: A retrospective study of consecutive surgical epicardial VT ablation cases from a single center was performed...
November 10, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29130830/enhanced-cd103-expression-and-reduced-frequencies-of-virus-specific-cd8-t-cells-among-airway-lymphocytes-after-influenza-vaccination-of-mice-deficient-in-vitamins-a%C3%A2-%C3%A2-d
#5
Sherri L Surman, Bart G Jones, David L Woodland, Julia L Hurwitz
Previous research has evaluated antibody responses toward an influenza virus vaccine in the context of deficiencies for vitamins A and D (VAD+VDD). Results showed that antibodies and antibody-forming cells in the respiratory tract were reduced in VAD+VDD mice. However, effectors were recovered when oral supplements of vitamins A + D were delivered at the time of vaccination. Here we address the question of how vaccine-induced CD8(+) T cell responses are affected by deficiencies for vitamins A + D. VAD+VDD and control mice were vaccinated with an intranasal, cold-adapted influenza virus A/Puerto Rico/8/34 vaccine, with or without oral supplements of vitamins A + D...
November 13, 2017: Viral Immunology
https://www.readbyqxmd.com/read/29128513/dihydroartemisinin-induced-caspase-dependent-apoptosis-through-inhibiting-the-specificity-protein-1-pathway-in-hepatocellular-carcinoma-sk-hep-1-cells
#6
Eunji Im, Changhwan Yeo, Hyo-Jeong Lee, Eun-Ok Lee
AIMS: Dihydroartemisinin (DHA) is a semi-synthetic derivative of artemisinin, well known for a safe and effective first-line antimalarial agent. This study investigated whether and how DHA induces apoptosis focusing on the specificity protein 1 (Sp1) pathway in hepatocellular carcinoma (HCC) SK-Hep-1 cells. MAIN METHODS: The cell viability was evaluated by MTT assay. Cell cycle analysis was performed after PI staining by flow cytometry system. Apoptosis was confirmed by DAPI staining and by detecting cytoplasmic histone-associated-DNA-fragments using a cell death detection ELISA(PLUS) kit...
November 8, 2017: Life Sciences
https://www.readbyqxmd.com/read/29126445/ykl-40-in-the-brain-and-cerebrospinal-fluid-of-neurodegenerative-dementias
#7
Franc Llorens, Katrin Thüne, Waqas Tahir, Eirini Kanata, Daniela Diaz-Lucena, Konstantinos Xanthopoulos, Eleni Kovatsi, Catharina Pleschka, Paula Garcia-Esparcia, Matthias Schmitz, Duru Ozbay, Susana Correia, Ângela Correia, Ira Milosevic, Olivier Andréoletti, Natalia Fernández-Borges, Ina M Vorberg, Markus Glatzel, Theodoros Sklaviadis, Juan Maria Torres, Susanne Krasemann, Raquel Sánchez-Valle, Isidro Ferrer, Inga Zerr
BACKGROUND: YKL-40 (also known as Chitinase 3-like 1) is a glycoprotein produced by inflammatory, cancer and stem cells. Its physiological role is not completely understood but YKL-40 is elevated in the brain and cerebrospinal fluid (CSF) in several neurological and neurodegenerative diseases associated with inflammatory processes. Yet the precise characterization of YKL-40 in dementia cases is missing. METHODS: In the present study, we comparatively analysed YKL-40 levels in the brain and CSF samples from neurodegenerative dementias of different aetiologies characterized by the presence of cortical pathology and disease-specific neuroinflammatory signatures...
November 10, 2017: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/29125073/erythrocyte-associated-amyloid-%C3%AE-as-potential-biomarker-to-diagnose-dementia
#8
Michele Lauriola, Giulia Paroni, Filomena Ciccone, Grazia D Onofrio, Leandro Cascavilla, Francesco Paris, Carolina Gravina, Maria Urbano, Davide Seripa, Antonio Greco
BACKGROUND: Although it is well known that Alzheimer's disease (AD) is associated with the progressive accumulation of amyloid β-peptide (Aβ) in the human brain, its pathogenic role has yet to be completely clarified. Aβ moves from the blood-brain barrier to the plasma and an increased Aβ production in brain could be associated with higher Aβ concentrations in blood. A recent study has evaluated Aβ-40 and Aβ-42 levels in human red blood cells (RBCs) with evidence of age-dependent higher Aβ concentration in RBCs...
November 10, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/29125058/edaravone-attenuates-oxidative-stress-induced-by-chronic-cerebral-hypoperfusion-injury-role-of-erk-nrf2-ho-1-signaling-pathway
#9
Dandan Zhang, Yining Xiao, Peiyuan Lv, Zhenjie Teng, Yanhong Dong, Qianqian Qi, Zhijuan Liu
Objectives The potential protective effects and mechanisms of edaravone have not been well elucidated in vascular dementia (VaD) induced by chronic cerebral hypoperfusion (CCH). The aim of this study was to investigate whether edaravone could improve cognitive damage in rats induced by CCH, and whether the effects of edaravone were associated with ERK/Nrf2/HO-1 signaling pathway. Methods CCH was induced by bilateral common carotid arteries occlusion (BCCAO). Sprague-Dawley (SD) rats were randomly divided into four groups: sham (sham-operated) group, vehicle (BCCAO + normal saline) group, edaravone3...
November 10, 2017: Neurological Research
https://www.readbyqxmd.com/read/29119731/development-and-current-clinical-application-of-ventricular-assist-devices-in-china
#10
Yue Wu, Liang-Fan Zhu, Yun Luo
Heart failure has become one of the biggest threats to human health. Transplantation remains the most effective therapy for heart failure, but because of the shortage of donors, it cannot meet the demand. Ventricular assist devices (VADs) were developed to treat heart failure, and have now been clinically applied worldwide. As the country with the largest population, China is also facing the threat of heart failure. However, the development of VADs in China is very slow and is seldom discussed. This paper first talks about the background for VAD development in China...
2017: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/29119540/discrimination-of-stroke-related-mild-cognitive-impairment-and-vascular-dementia-using-eeg-signal-analysis
#11
Noor Kamal Al-Qazzaz, Sawal Hamid Bin Mohd Ali, Siti Anom Ahmad, Mohd Shabiul Islam, Javier Escudero
Stroke survivors are more prone to developing cognitive impairment and dementia. Dementia detection is a challenge for supporting personalized healthcare. This study analyzes the electroencephalogram (EEG) background activity of 5 vascular dementia (VaD) patients, 15 stroke-related patients with mild cognitive impairment (MCI), and 15 control healthy subjects during a working memory (WM) task. The objective of this study is twofold. First, it aims to enhance the discrimination of VaD, stroke-related MCI patients, and control subjects using fuzzy neighborhood preserving analysis with QR-decomposition (FNPAQR); second, it aims to extract and investigate the spectral features that characterize the post-stroke dementia patients compared to the control subjects...
November 8, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29117039/optimization-of-axial-pump-characteristic-dimensions-and-induced-hemolysis-for-mechanical-circulatory-support-devices
#12
Theodosios Korakianitis, Mohammad A Rezaienia, Gordon M Paul, Eldad J Avital, Martin T Rothman, Sahand Mozafari
The application of axial pumps as ventricular assist devices (VADs) requires significant modifications to the size and characteristics of industrial pumps due to the difference in flow fields of industrial and medical pumps. Industrial pumps operate in the region of Reynolds number Re = 108, whereas axial blood pumps operate in Re < 10. The common pump design technique is to rely on the performance of previously designed pumps using the concept of fluid dynamic similarity. Such data are available for industrial pumps as specific speed-specific diameter (ns-ds) graphs...
November 7, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29115629/oxymatrine-induces-a549-human-non%C3%A2-small-lung-cancer-cell-apoptosis-via-extrinsic-and-intrinsic-pathways
#13
Guang-Zhou Zhou, Yan-Yan Shi, Liu-Su Cui, A-Fang Li, Qing-Qing Wang, Min Liu
Oxymatrine is one of the primary natural compounds extracted from the Sophora flavescens, and has been reported to exhibit numerous pharmacological properties including cancer‑preventive and anti‑cancer effects, however the mechanisms as to how oxymatrine exhibits anti‑proliferative activity in non‑small cell lung carcinoma cells remains uncertain. The present study aimed to explore the mechanism of its anti‑cancer effect, and whether it is due to apoptosis induction and anti‑migration in the A549 lung cancer cell line...
November 6, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29110794/anesthetic-management-of-the-patient-with-a-ventricular-assist-device
#14
REVIEW
Marie-Louise Meng, Jessica Spellman
The use of long- and short-term mechanical circulatory support in the form of ventricular assist device (VAD) has increased over the last decade. Although cardiothoracic anesthesiologists care for these patients during device placement, increasingly higher numbers of general anesthesiologists are involved in the management of VAD patients during noncardiac surgery and procedures. An understanding of devices, their indications, and complications is essential to the anesthesiologists caring for these patients...
June 2017: Best Practice & Research. Clinical Anaesthesiology
https://www.readbyqxmd.com/read/29107545/infectious-complications-of-ventricular-assist-device-use-in-children-in-the-united-states-data-from-the-pediatric-interagency-registry-for-mechanical-circulatory-support-pedimacs
#15
Scott R Auerbach, Marc E Richmond, Kurt R Schumacher, Dalia Lopez-Colon, Max B Mitchell, Mark W Turrentine, Ryan S Cantor, Robert A Niebler, Pirooz Eghtesady
BACKGROUND: Infections are frequent in pediatric ventricular assist device (VAD) patients. In this study we aimed to describe infections in durable VAD patients reported to Pedimacs. METHODS: Durable VAD data from the Pedimacs registry (September 19, 2012 to December 31, 2015) were analyzed. Infections were described with standard descriptive statistics, Kaplan-Meier analysis and competing outcomes analysis. RESULTS: There were 248 implants in 222 patients, with a mean age and a median follow-up of 11 ± 6...
October 3, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29103857/phenotype-management-and-predictors-of-outcome-in-a-large-cohort-of-adult-congenital-heart-disease-patients-with-heart-failure
#16
Alexander Van De Bruaene, Edward J Hickey, Adrienne H Kovacs, Andrew M Crean, Rachel M Wald, Candice K Silversides, Andrew N Redington, Heather J Ross, Ana Carolina Alba, Filio Billia, Krishnakumar Nair, Lee Benson, Eric Horlick, Mark Osten, Jack Colman, Jane Heggie, Erwin N Oechslin, S Lucy Roche
OBJECTIVE: Although heart failure (HF) is the leading cause of premature death in adult congenital heart disease (ACHD), little population-specific data exist. This study reports early experience from a dedicated, sub-specialty adult congenital heart disease-heart failure (ACHD-HF) clinic, aiming to identify risk factors for adverse outcome. METHODS: Between 2012 and 2015, 126 patients (57% male) attended the ACHD-HF clinic. Baseline and follow-up data were analysed and compared across 4 anatomical/physiological subgroups: cyanotic ACHD, Fontan circulation (1V), biventricular circulation with a subaortic right ventricle (2V-RV) and biventricular circulation with a subaortic left ventricle (2V-LV)...
October 31, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29103459/protective-effect-of-shouwu-yizhi-decoction-against-vascular-dementia-by-promoting-angiogenesis
#17
Xiao-Ni Yang, Chang-Sheng Li, Chao Chen, Xiao-Yong Tang, Guang-Qing Cheng, Xia Li
Shouwu is a traditional Chinese medicine (TCM) with neuroprotective effect. Shouwu Yizhi decoction (SYD) was designed based on TCM theory. However, little is known about the roles of SYD in Vascular dementia (VaD). The present study aimed to evaluate the potential effects of SYD on the vascular cognitive impairment and explore the underlying mechanism by establishing focal cerebral ischemia/reperfusion (I/R) rat model to induce VaD. SYD administration (54 mg·kg(-1)) for 40 days obviously improved the vascular cognitive impairment in the middle cerebral artery occlusion (MCAO) rats as evidenced by the declined neurological deficit score and shortened escape latency via neurological deficit assessment and Morris water maze test...
October 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29100319/berberine-and-cinnamaldehyde-together-prevent-lung-carcinogenesis
#18
Mingjing Meng, Shengnan Geng, Zhenhua Du, Jingjing Yao, Yaqiu Zheng, Zibo Li, Zhenzhen Zhang, Jiahuan Li, Yongjian Duan, Gangjun Du
Starving tumor cells by restricting nutrient sources is a promising strategy for combating cancer. Because both berberine and cinnamaldehyde can activate AMP-activated protein kinase (AMPK, a sensor of cellular energy status), we investigated whether the combination of berberine and cinnamaldehyde could synergistically prevent lung carcinogenesis through tumor cell starvation. Urethane treatment induced lung carcinogenesis in mice, downregulated AMPK and mammalian target of rapamycin (mTOR) while upregulating aquaporin-1 (AQP-1) and nuclear factor kappa B (NF-κB)...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29096553/improved-identification-of-the-electrocardio-signal-for-pulsatile-ventricular-assist-devices
#19
Xinghui Li, Lin Luo, Shidong Zhu, Bibo Yang, Kai Ni, Qian Zhou, Xiaohao Wang
We introduce and investigate a method to identify the feature point of an electrocardiogram (ECG) to provide real-time and accurate trigger signals for pulsatile ventricular assist devices (PVADs). An important part of this method is an improved data processing algorithm, in which a differential calculator and another a low-pass filtering were added to avoid drift in the original signal and systematically delay caused by physical devices. The method was systematically illustrated in this article and a test-setup was built based on the LabVIEW program development environment...
November 3, 2017: Computer Assisted Surgery (Abingdon, England)
https://www.readbyqxmd.com/read/29095737/long-term-right-ventricular-assist-device-therapy-in-an-adult-with-pulmonary-atresia-intact-ventricular-septum
#20
Joshua L Hermsen, Karen K Stout, April Stempien-Otero, Edward D Verrier, Nahush A Mokadam
Durable ventricular assist device (VAD) support is uncommonly employed in adult congenital heart disease and often involves supporting a systemic right ventricle (RV). Ventricular assist device support of a subpulmonic RV is even more unusual.
October 31, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
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