keyword
https://read.qxmd.com/read/38492760/vascular-access-device-type-for-systemic-anti-cancer-therapies-in-cancer-patients-a-scoping-review
#1
REVIEW
C Duggan, O Hernon, R Dunne, V McInerney, S R Walsh, A Lowery, M McCarthy, P J Carr
BACKGROUND: Patients with cancer can expect to receive numerous invasive vascular access procedures for intravenous therapy and clinical diagnostics. Due to the increased incidence and prevalence of cancer globally there will be significantly more people who require first-line intravenous chemotherapy over the next ten years. METHODS: Our objective was to determine the types of evidence that exist for the vascular access device (VAD) type for the delivery of systemic anti-cancer therapy (SACT) in cancer patients...
March 14, 2024: Critical Reviews in Oncology/hematology
https://read.qxmd.com/read/38492747/air-pollution-apoe-genotype-and-risk-of-dementia-among-individuals-with-cardiovascular-diseases-a-population-based-longitudinal-study
#2
JOURNAL ARTICLE
Fei Tian, Zhengmin Qian, Zilong Zhang, Yuewei Liu, Gan Wu, Chongjian Wang, Stephen Edward McMillin, Elizabeth Bingheim, Hualiang Lin
Individuals with cardiovascular disease (CVD) are particularly vulnerable to dementia, but it remains unclear whether air pollution exposure links with higher risk of dementia among those with CVD. The data were derived from the UK Biobank study (UKB). Dementia-free participants with CVD at baseline were included. Air pollution exposure was assessed through land use regression models, including particulate matter (PM2.5 , PM2.5-10 , and PM10 ), nitrogen dioxide (NO2 ), and nitrogen oxides (NOX ). A Cox proportional hazards model was used to investigate the associations between air pollution exposure and incident dementia among individuals with CVD...
March 14, 2024: Environmental Pollution
https://read.qxmd.com/read/38491466/causal-relationship-between-dietary-salt-intake-and-dementia-risk-mendelian-randomization-study
#3
JOURNAL ARTICLE
Ke Shi, Yongbo Yu, Zhaolin Li, Miaomiao Hou, Xinyi Li
OBJECTIVE: Observational research has indicated a potential link between dietary salt intake and susceptibility to dementia. However, it is important to note that these types of studies are prone to the issues of reverse causation and residual confounding. Therefore, we conducted a two-sample Mendelian randomization (MR) study to explore the causality. METHOD: To explore the causal relationship between them, this Mendelian randomization (MR) study incorporated summary statistics of dietary salt intake and dementia...
March 15, 2024: Genes & Nutrition
https://read.qxmd.com/read/38470582/towards-video-anomaly-retrieval-from-video-anomaly-detection-new-benchmarks-and-model
#4
JOURNAL ARTICLE
Peng Wu, Jing Liu, Xiangteng He, Yuxin Peng, Peng Wang, Yanning Zhang
Video anomaly detection (VAD) has been paid increasing attention due to its potential applications, its current dominant tasks focus on online detecting anomalies, which can be roughly interpreted as the binary or multiple event classification. However, such a setup that builds relationships between complicated anomalous events and single labels, e.g., "vandalism", is superficial, since single labels are deficient to characterize anomalous events. In reality, users tend to search a specific video rather than a series of approximate videos...
March 12, 2024: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://read.qxmd.com/read/38461378/biventricular-catheterization-combined-with-pressure-volume-loop-monitoring-provides-insight-into-the-dynamic-effects-of-left-ventricular-assist-devices-ramp-on-right-ventricular-function
#5
Armin Garmany, Sara S Inglis, Atta Behfar, Andrew N Rosenbaum
Ramp studies are utilized for speed optimization of continuous flow left ventricular assist devices (CF-LVADs). We here report the utility of combined left and right heart catheterization during a ramp study to ensure a comprehensive understanding of the hemodynamic implications on both ventricles. Pressure-volume loop (PV loop) monitoring uncovered compromised systolic and mildly compromised right ventricular function with increasing LVAD speeds, despite improvement in left ventricular unloading. These findings informed patient management and highlight the potential utility of PV loop monitoring as an adjunct to left and right heart catheterization during ramp studies of next-generation LVADs...
March 10, 2024: Catheterization and Cardiovascular Interventions
https://read.qxmd.com/read/38456480/norcantharidin-inhibits-the-malignant-progression-of-cervical-cancer-by-inducing-endoplasmic-reticulum-stress
#6
JOURNAL ARTICLE
Zhongbao Zhang, Beibei Sun, Jinqiu Lu, Penglai Bai, Yu Su, Yanchun Li
The antitumor effect of norcantharidin (NCTD) has been widely reported. However, whether NCTD can inhibit cervical cancer remains unknown. In the present study, it was shown that NCTD inhibited the viability of cervical cancer cells and caused cell cycle arrest in a concentration‑dependent manner. Further analysis revealed that the NCTD‑induced reduction in cell viability could be reversed by the inhibitor of apoptosis z‑VAD‑FMK and by the inhibitor of endoplasmic reticulum (ER) stress, 4‑phenylbutyric acid (4‑PBA)...
May 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38454306/dysregulation-of-the-renin-angiotensin-system-in-vascular-dementia
#7
JOURNAL ARTICLE
H M Tayler, O A Skrobot, D H Baron, P G Kehoe, J S Miners
The renin-angiotensin system (RAS) regulates systemic and cerebral blood flow and is dysregulated in dementia. The major aim of this study was to determine if RAS signalling is dysregulated in vascular dementia. We measured markers of RAS signalling in white matter underlying the frontal and occipital cortex in neuropathologically confirmed cases of vascular dementia (n = 42), Alzheimer's disease (n = 50), mixed AD/VaD (n = 50) and age-matched controls (n = 50)...
March 7, 2024: Brain Pathology
https://read.qxmd.com/read/38452989/circulating-cytokines-and-vascular-dementia-a-bi-directional-mendelian-randomization-study
#8
JOURNAL ARTICLE
Yuge Xia, Zhirui Xu, Yicong Zhang, Dongli Jiang, Yunyi Zhu, Xiaolun Liang, Rui Sun
Inflammatory responses are associated with the development of vascular dementia (VaD). Circulating cytokines modulate the inflammatory response and are important for the immune system. To further elucidate the role of the immune system in VaD, we used Mendelian randomization (MR) to comprehensively and bi-directionally assess the role of circulating cytokines in VaD. Using state-of-the-art genome-wide association studies, we primarily assessed whether different genetic levels of 41 circulating cytokines affect the risk of developing VaD and, in turn, whether the genetic risk of VaD affects these circulating cytokines...
March 5, 2024: Experimental Gerontology
https://read.qxmd.com/read/38450229/clinical-vitamin-a-deficiency-among-preschool-aged-children-in-southwest-ethiopia
#9
JOURNAL ARTICLE
Abdilwahid Nuredin, Tamirat Melis, Abdu Oumer Abdu
BACKGROUND: The clinical manifestations of vitamin A deficiency (VAD) involve night blindness, bitot's spots, corneal xerosis, and corneal scars. It is the most important cause of preventable childhood blindness among children and causes morbidity and mortality. Even though Ethiopia implemented high-potency vitamin A supplements, the occurrence of VAD remains significant. This study was to identify determinants of clinical VAD among preschool-aged children (PSC) in southwest Ethiopia...
2024: Frontiers in Nutrition
https://read.qxmd.com/read/38445327/emergency-medical-services-protocols-for-assessment-and-treatment-of-patients-with-ventricular-assist-devices
#10
JOURNAL ARTICLE
Emily L Larson, JiWon Woo, Gyeongtae Moon, Kathy Liu, Matthew Vergel, Reed Jenkins, Kelly Jiang, Zachary Darby, Asa Margolis, Ahmet Kilic
BACKGROUND: Patients with ventricular assist devices (VADs) represent a growing population presenting to Emergency Medical Services (EMS), but little is known about their prehospital care. This study aimed to characterize current EMS protocols in the United States for patients with VADs. METHODS: States with state-wide EMS protocols were included. Protocols were obtained from the state EMS website. If not available, the office of the state medical director was contacted...
March 6, 2024: Prehospital and Disaster Medicine
https://read.qxmd.com/read/38444163/fucoxanthin-induces-human-melanoma-cytotoxicity-by-thwarting-the-jak2-stat3-bcl-xl-signaling-axis
#11
JOURNAL ARTICLE
Min-Yung Kuo, Wen-Chyi Dai, Jie-Li Chang, Jo-Shu Chang, Tse-Min Lee, Chia-Che Chang
Melanoma is the most lethal skin malignancy. Fucoxanthin is a marine carotenoid with significant anticancer activities. Intriguingly, Fucoxanthin's impact on human melanoma remains elusive. Signal Transducer and Activator of Transcription 3 (STAT3) represents a promising target in cancer therapy due to its persistent activation in various cancers, including melanoma. Herein, we revealed that Fucoxanthin is cytotoxic to human melanoma cell lines A2758 and A375 while showing limited cytotoxicity to normal human melanocytes...
March 5, 2024: Environmental Toxicology
https://read.qxmd.com/read/38438522/hypointense-signal-lesion-on-susceptibility-weighted-imaging-as-a-potential-indicator-of-vertebral-artery-dissection-in-medullary-infarction
#12
JOURNAL ARTICLE
Euihyun Sung, Wonjae Sung, Young-Jun Lee, So Yeong Jeong, Soo Jeong, Hyun Young Kim, Hyuk Sung Kwon, Seong-Ho Koh, Young Seo Kim
Vertebral artery dissection (VAD) is often associated with medullary infarction; however, an underlying cause may be underestimated. This study aimed to assess the diagnostic potential of hypointense signal lesions along the arterial pathways using susceptibility-weighted imaging (SWI) as a feasible indicator of VAD in medullary infarction. A retrospective analysis was conducted using clinical data, brain magnetic resonance imaging, and angiography records of 79 patients diagnosed with medullary infarction between January 2014 and December 2021...
March 4, 2024: Scientific Reports
https://read.qxmd.com/read/38432247/cetuximab-versus-methotrexate-in-first-line-treatment-of-older-frail-patients-with-inoperable-recurrent-or-metastatic-head-and-neck-cancer-elan-unfit-a-randomised-open-label-phase-3-trial
#13
RANDOMIZED CONTROLLED TRIAL
Joël Guigay, Cécile Ortholan, Damien Vansteene, Didier Cupissol, Caroline Even, Marie-Christine Kaminsky, Christian Sire, Emmanuel Blot, Philippe Debourdeau, Laurence Bozec, Esma Saada-Bouzid, Jérôme Fayette, Pierre Dalloz, Yoann Pointreau, Hervé Le Caer, Claire Falandry, Laurence Digue, Antoine Braccini, Stéphane Lopez, Pierre Guillet, Cécile Michel, Nadir Cheurfa, Dominique Schwob, Jean Bourhis, Cécile Mertens, Anne Aupérin
BACKGROUND: At present, there is no established standard treatment for frail older patients with recurrent or metastatic head and neck squamous cell carcinoma. We aimed to compare the efficacy and safety of cetuximab to those of methotrexate (the reference regimen) in this population. METHODS: This randomised, open-label, phase 3 trial was done at 20 hospitals in France. Patients aged 70 years or older, assessed as frail by the ELAN Geriatric Evaluation, with recurrent or metastatic head and neck squamous cell carcinoma in the first-line setting and with an Eastern Cooperative Oncology Group (ECOG) performance status of 0-2 were eligible for inclusion...
March 2024: The Lancet. Healthy longevity
https://read.qxmd.com/read/38431549/determining-optimal-cutoff-scores-of-cognitive-abilities-screening-instrument-to-identify-dementia-and-mild-cognitive-impairment-in-taiwan
#14
JOURNAL ARTICLE
Wan-Jing Lyu, Pai-Yi Chiu, Chung-Hsiang Liu, Yu-Chi Liao, Hsin-Te Chang
BACKGROUND: The early detection of dementia depends on efficient methods for the assessment of cognitive capacity. Existing cognitive screening tools are ill-suited to the differentiation of cognitive status, particularly when dealing with early-stage impairment. METHODS: The study included 8,979 individuals (> 50 years) with unimpaired cognitive functions, mild cognitive impairment (MCI), or dementia. This study sought to determine optimal cutoffs values for the Cognitive Abilities Screening Instrument (CASI) aimed at differentiating between individuals with or without dementia as well as between individuals with or without mild cognitive impairment...
March 2, 2024: BMC Geriatrics
https://read.qxmd.com/read/38430579/the-mechanism-of-nickel-induced-autophagy-and-its-role-in-nephrotoxicity
#15
JOURNAL ARTICLE
Heng Yin, Chengbi Wang, Hongrui Guo, Xiaocong Li, Jingbo Liu
Nickel (Ni), an environmental health hazard, is nephrotoxic to humans, but the exact mechanism is unknown. This study aims to identify whether nephrotoxicity is associated with autophagy. Here, nickel chloride (NiCl2 ) increased autophagy in TCMK-1 cells. NiCl2 induces autophagy through Akt and AMPK/mTOR pathways. Next, oxidative stress was investigated in NiCl2 -induced autophagy. The findings demonstrated that the antioxidant (NAC) or mitochondrial targeted antioxidant (Mito-TEMPO) attenuated NiCl2 -induced autophagy, reversed the influence on AMPK-mTOR and Akt pathways...
March 1, 2024: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/38427737/targeting-postsynaptic-glutamate-receptor-scaffolding-proteins-psd-95-and-pick1-for-obesity-treatment
#16
JOURNAL ARTICLE
Nicole Fadahunsi, Jonas Petersen, Sophia Metz, Alexander Jakobsen, Cecilie Vad Mathiesen, Alberte Silke Buch-Rasmussen, Nigel Kurgan, Jeppe Kjærgaard Larsen, Rita C Andersen, Thomas Topilko, Charlotte Svendsen, Mia Apuschkin, Grethe Skovbjerg, Jan Hendrik Schmidt, Grace Houser, Sara Elgaard Jager, Anders Bach, Atul S Deshmukh, Tuomas O Kilpeläinen, Kristian Strømgaard, Kenneth L Madsen, Christoffer Clemmensen
Human genome-wide association studies (GWAS) suggest a functional role for central glutamate receptor signaling and plasticity in body weight regulation. Here, we use UK Biobank GWAS summary statistics of body mass index (BMI) and body fat percentage (BF%) to identify genes encoding proteins known to interact with postsynaptic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N -methyl-d-aspartate (NMDA) receptors. Loci in/near discs large homolog 4 ( DLG4 ) and protein interacting with C kinase 1 ( PICK1 ) reached genome-wide significance ( P < 5 × 10 - 8 ) for BF% and/or BMI...
March 2024: Science Advances
https://read.qxmd.com/read/38419587/successful-explantation-of-children-from-the-berlin-heart-excor%C3%A2-ventricular-assist-device-a-systematic-review
#17
REVIEW
Matthew F Mikulski, Swati Iyer, Andrew Well, Carlos M Mery, W Richard Owens, Lauren D Glass, Chesney D Castleberry, Charles D Fraser
BACKGROUND: The Berlin Heart EXCOR® (BHE) can bridge children with severe heart failure to transplantation, but some are successfully weaned and spared transplantation. This study seeks to identify characteristics of children amenable to successful explantation with BHE support. METHODS: Preferred Reporting Items for Systematic reviews and Meta-Analyses 2020 guidelines were used. Five databases were screened for original, English articles measuring BHE support in patients <18 years old based on title and abstract...
February 29, 2024: Artificial Organs
https://read.qxmd.com/read/38418690/effect-of-rvad-cannulation-length-on-right-ventricular-thrombosis-risk-an-in-silico-investigation
#18
JOURNAL ARTICLE
Kar Ying Thum, Sam Liao, Michael Šeman, Mehrdad Khamooshi, Josie Carberry, David McGiffin, Shaun D Gregory
Left ventricular assist devices (LVADs) have been used off-label as long-term support of the right heart due to the lack of a clinically approved durable right VAD (RVAD). Whilst various techniques to reduce RVAD inflow cannula protrusion have been described, the implication of the protrusion length on right heart blood flow and subsequent risk of thrombosis remains poorly understood. This study investigates the influence of RVAD diaphragmatic cannulation length on right ventricular thrombosis risk using a patient-specific right ventricle in silico model validated with particle image velocimetry...
February 28, 2024: Annals of Biomedical Engineering
https://read.qxmd.com/read/38412449/postural-control-characteristics-in-alzheimer-s-disease-dementia-with-lewy-bodies-and-vascular-dementia
#19
JOURNAL ARTICLE
Kosuke Fujita, Taiki Sugimoto, Hisashi Noma, Yujiro Kuroda, Nanae Matsumoto, Kazuaki Uchida, Yoshinobu Kishino, Takashi Sakurai
BACKGROUND: Dementia often results in postural control impairment, which could signify central nervous system dysfunction. However, no studies have compared postural control characteristics among various types of dementia. This study aimed to compare static postural control in patients with Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and vascular dementia (VaD). METHODS: Cross-sectional relationship between the clinical diagnoses (AD, DLB, VaD, or normal cognition [NC]) of outpatients at a memory clinic and their upright postural control characteristics were examined...
February 27, 2024: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/38412164/a-comparative-study-of-apoptosis-pyroptosis-necroptosis-and-panoptosis-components-in-mouse-and-human-cells
#20
JOURNAL ARTICLE
Sk Mohiuddin Choudhury, Roman Sarkar, Rajendra Karki, Thirumala-Devi Kanneganti
Regulated cell death is a key component of the innate immune response, which provides the first line of defense against infection and homeostatic perturbations. However, cell death can also drive pathogenesis. The most well-defined cell death pathways can be categorized as nonlytic (apoptosis) and lytic (pyroptosis, necroptosis, and PANoptosis). While specific triggers are known to induce each of these cell death pathways, it is unclear whether all cell types express the cell death proteins required to activate these pathways...
2024: PloS One
keyword
keyword
59588
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.