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https://www.readbyqxmd.com/read/28738312/habitual-sleep-quality-and-diurnal-rhythms-of-salivary-cortisol-and-dehydroepiandrosterone-in-postmenopausal-women
#1
Tianyi Huang, Elizabeth M Poole, Celine Vetter, Kathryn M Rexrode, Laura D Kubzansky, Eva Schernhammer, Nicolas Rohleder, Frank B Hu, Susan Redline, Shelley S Tworoger
Dysregulation of the hypothalamus-pituitary-adrenal (HPA) axis has been suggested as a potential mechanism linking sleep and cardiometabolic disorders. However, the associations of two primary outputs of the HPA axis, cortisol and its antagonist dehydroepiandrosterone (DHEA), with sleep are less well studied. In the Nurses' Health Study II, 233 postmenopausal women provided five timed saliva samples over one day (immediately upon waking, 45min, 4h, and 10h after waking, and prior to going to sleep) to measure cortisol and DHEA...
July 19, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28738280/cobalt-fibers-anchored-with-tin-disulfide-nanosheets-as-high-performance-anode-materials-for-lithium-ion-batteries
#2
Xuefang Chen, Ying Huang, Kaichuang Zhang, Weichao Zhang
Well-designed hierarchical nanostructured composites consisting of one dimensional cobalt fibers and thin tin disulfide nanosheets were successfully synthesized for the first time through a hydrothermal method. The SnS2 nanosheets were uniformly grown onto the Co fibers and were almost perpendicular to the Co fibers. The composites as one kind anode materials exhibited more remarkable lithium ion storage properties than SnS2 nanosheets. The composites exhibited a capacity of 500.5mAh/g after 100 cycles even at 1000mA/g...
July 18, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28738266/adhd-symptoms-impact-smoking-outcomes-and-withdrawal-in-response-to-varenicline-treatment-for-smoking-cessation
#3
L Cinnamon Bidwell, Hollis C Karoly, Kent E Hutchison, Angela D Bryan
INTRODUCTION: Attention-Deficit/Hyperactivity Disorder (ADHD) is associated with nicotine dependence and difficulty quitting smoking. Few cessation trials specifically consider the impact of ADHD on treatment outcomes, including those testing established pharmacological therapies, such as varenicline. METHODS: The current study focused on the impact of pretreatment ADHD inattention (IN) and hyperactivity-impulsivity (HI) symptoms on treatment outcome in a randomized controlled trial of varenicline [N=205, average age=34...
July 18, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28738219/finding-features-figuratively
#4
Sarah H Solomon, Sharon L Thompson-Schill
Object concepts refer to unique clusters of properties that can be selectively activated or inhibited depending on what information is currently relevant. This conceptual "stretching" enables limitless new meanings to be generated, and figurative language provides a useful framework in which to study this conceptual flexibility. Here we probe the cognitive and neural mechanisms underlying the comprehension of novel metaphors as a means of understanding the conceptual flexibility inherent to language processing more generally...
July 21, 2017: Brain and Language
https://www.readbyqxmd.com/read/28738165/physical-and-mechanical-therapies-for-lower-limb-problems-in-juvenile-idiopathic-arthritis-a-systematic-review-with-meta-analysis
#5
Antoni Fellas, Andrea Coda, Fiona Hawke
BACKGROUND: Juvenile Idiopathic Arthritis (JIA) is a chronic, autoimmune, inflammatory joint disease and is the most common arthritis affecting children under 16 years of age. Children with JIA commonly experience lower limb dysfunction and disability. OBJECTIVE: To systematically review the effectiveness of physical and mechanical therapies for lower limb problems JIA. METHODS: Randomised control trials (RCT) of physical and mechanical interventions for lower limb problems in children with JIA were included...
July 24, 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/28738141/quantification-of-chemical-and-mechanical-effects-on-the-formation-of-g-quadruplex-and-i-motif-in-duplex-dna
#6
Sangeetha Selvam, Shankar Mandal, Hanbin Mao
Formation of biologically significant tetraplex DNA species, such as G-quadruplexes and i-motifs, is affected by chemical (ions and pH) and mechanical (superhelicity [σ] and molecular crowding) factors. Due to the extremely challenging experimental conditions, relative im-portance of these factors on tetraplex folding is unknown. In this work, we quantitatively evalu-ated the chemical and mechanical effects on the population dynamics of DNA tetraplexes in In-sulin Linked Polymorphic Region using magneto-optical tweezers...
July 24, 2017: Biochemistry
https://www.readbyqxmd.com/read/28737972/identifying-health-information-technology-needs-of-oncologists-to-facilitate-the-adoption-of-genomic-medicine-recommendations-from-the-2016-american-society-of-clinical-oncology-omics-and-precision-oncology-workshop
#7
Kevin S Hughes, Edward P Ambinder, Gregory P Hess, Peter Paul Yu, Elmer V Bernstam, Mark J Routbort, Jean Rene Clemenceau, John T Hamm, Phillip G Febbo, Susan M Domchek, James L Chen, Jeremy L Warner
At the ASCO Data Standards and Interoperability Summit held in May 2016, it was unanimously decided that four areas of current oncology clinical practice have serious, unmet health information technology needs. The following areas of need were identified: 1) omics and precision oncology, 2) advancing interoperability, 3) patient engagement, and 4) value-based oncology. To begin to address these issues, ASCO convened two complementary workshops: the Omics and Precision Oncology Workshop in October 2016 and the Advancing Interoperability Workshop in December 2016...
July 24, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28737944/in-situ-generated-glycinyl-chloroaminals-for-a-one-pot-synthesis-of-non-proteinogenic-%C3%AE-amino-esters
#8
Shyam S Samanta, Stephane P Roche
An acetyl chloride-mediated cascade transformation involving a primary carbamate, ethyl glyoxylate and various types of nucleophiles is reported for the synthesis of orthogonally protected α-amino esters. These reactions proceeded rapidly to afford the pivotal α-chloroglycine intermediate in excellent yields which can be directly functionalized in situ with various types of nucleophiles. A mild and unique AcOH(cat.)/AcCl system was found to promote an autocatalytic-like condensation and facilitate the multicomponent assembly of non-proteinogenic α-amino esters...
July 24, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28737772/cortical-forces-and-cdc-42-control-clustering-of-par%C3%A2-proteins-for-caenorhabditis-elegans-embryonic%C3%A2-polarization
#9
Shyi-Chyi Wang, Tricia Yu Feng Low, Yukako Nishimura, Laurent Gole, Weimiao Yu, Fumio Motegi
Cell polarization enables zygotes to acquire spatial asymmetry, which in turn patterns cellular and tissue axes during development. Local modification in the actomyosin cytoskeleton mediates spatial segregation of partitioning-defective (PAR) proteins at the cortex, but how mechanical changes in the cytoskeleton are transmitted to PAR proteins remains elusive. Here we uncover a role of actomyosin contractility in the remodelling of PAR proteins through cortical clustering. During embryonic polarization in Caenorhabditis elegans, actomyosin contractility and the resultant cortical tension stimulate clustering of PAR-3 at the cortex...
July 24, 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28737763/melanoma-subtypes-demonstrate-distinct-pd-l1-expression-profiles
#10
Genevieve J Kaunitz, Tricia R Cottrell, Mohammed Lilo, Valliammai Muthappan, Jessica Esandrio, Sneha Berry, Haiying Xu, Aleksandra Ogurtsova, Robert A Anders, Alexander H Fischer, Stefan Kraft, Meg R Gerstenblith, Cheryl L Thompson, Kord Honda, Jonathan D Cuda, Charles G Eberhart, James T Handa, Evan J Lipson, Janis M Taube
PD-L1 expression in the tumor immune microenvironment is recognized as both a prognostic and predictive biomarker in patients with cutaneous melanoma, a finding closely related to its adaptive (IFN-γ-mediated) mechanism of expression. Approximately 35% of cutaneous melanomas express PD-L1, however, the expression patterns, levels, and prevalence in rarer melanoma subtypes are not well described. We performed immunohistochemistry for PD-L1 and CD8 on 200 formalin-fixed paraffin-embedded specimens from patients with acral (n=16), mucosal (n=36), uveal (n=103), and chronic sun-damaged (CSD) (n=45) melanomas (24 lentigo maligna, 13 'mixed' desmoplastic, and 8 'pure' desmoplastic melanomas)...
July 24, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28737762/mechanism-of-host-substrate-acetylation-by-a-yopj-family-effector
#11
Zhi-Min Zhang, Ka-Wai Ma, Linfeng Gao, Zhenquan Hu, Simon Schwizer, Wenbo Ma, Jikui Song
The Yersinia outer protein J (YopJ) family of bacterial effectors depends on a novel acetyltransferase domain to acetylate signalling proteins from plant and animal hosts. However, the underlying mechanism is unclear. Here, we report the crystal structures of PopP2, a YopJ effector produced by the plant pathogen Ralstonia solanacearum, in complex with inositol hexaphosphate (InsP6), acetyl-coenzyme A (AcCoA) and/or substrate Resistance to Ralstonia solanacearum 1 (RRS1-R)WRKY. PopP2 recognizes the WRKYGQK motif of RRS1-RWRKY to position a targeted lysine in the active site for acetylation...
July 24, 2017: Nature Plants
https://www.readbyqxmd.com/read/28737701/application-of-extrusion-based-hydrogel-bioprinting-for-cartilage-tissue-engineering
#12
REVIEW
Fu You, B Frank Eames, Xiongbiao Chen
Extrusion-based bioprinting (EBB) is a rapidly developing technique that has made substantial progress in the fabrication of constructs for cartilage tissue engineering (CTE) over the past decade. With this technique, cell-laden hydrogels or bio-inks have been extruded onto printing stages, layer-by-layer, to form three-dimensional (3D) constructs with varying sizes, shapes, and resolutions. This paper reviews the cell sources and hydrogels that can be used for bio-ink formulations in CTE application. Additionally, this paper discusses the important properties of bio-inks to be applied in the EBB technique, including biocompatibility, printability, as well as mechanical properties...
July 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28737600/an-interprofessional-quality-improvement-initiative-to-standardize-pediatric-extubation-readiness-assessment
#13
Samer Abu-Sultaneh, Acrista J Hole, Alvaro J Tori, Brain D Benneyworth, Riad Lutfi, Christopher W Mastropietro
OBJECTIVES: Establishing protocols to wean mechanical ventilation and assess readiness for extubation, with the goal of minimizing morbidity associated with extubation failure and prolonged mechanical ventilation, have become increasingly important in contemporary PICUs. The aim of this quality improvement initiative is to establish a respiratory therapist-led daily spontaneous breathing trial protocol to standardize extubation readiness assessment and documentation in our PICU. DESIGN: A quality improvement project...
July 21, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28737356/-the-hospital-patients-health-and-territories-act-and-the-recentralisation-of-the-social-and-long-term-care-sector
#14
Alain Jourdain, Jorge Muñoz, Hervé Hudebine
Hypothesis: The 2009 Hospital, Patients, Health and Territories Act crystallises a central government attempt to regain control over the social and long term care sector, which involves the utilisation of policy instruments borrowed from the hospital sector: capped budgets, agreements on targets and resources, competitive tendering or quasi-market mechanisms involving hospitals and services, etc. This paper is therefore based on the hypothesis of a recentralisation and healthicization of the social and long term care sector, with a key role for the regional health authorities...
July 10, 2017: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/28737323/-complexity-concept-and-challenges-for-public-health-interventions
#15
Victoria Pagani, Joëlle Kivits, Laetitia Minary, Linda Cambon, Frédérique Claudot, François Alla
: The notions of complexity and complex interventions have implications for researchers and users of the results of research. In particular, the notion of complexity is designed to provide a better understanding of the mechanism of effectiveness of interventions, support transferability and use by actors and decision-makers.<np pagenum="032"/> </ce:para>.
March 6, 2017: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/28737273/recovery-free-of-heart-failure-after-acute-coronary-syndrome-and-coronary-revascularization
#16
Alec Falkenham, Manu K Saraswat, Chloe Wong, Kareem Gawdat, Tanya Myers, Jahanara Begum, Karen J Buth, Ian Haidl, Jean Marshall, Jean-Francois Légaré
AIMS: Previous studies have examined risk factors for the development of heart failure (HF) subsequent to acute coronary syndrome (ACS). Our study seeks to clarify the clinical variables that best characterize patients who remain free from HF after coronary artery bypass grafting (CABG) surgery for ACS to determine novel biological factors favouring freedom from HF in prospective translational studies. METHODS AND RESULTS: Nova Scotia residents (1995-2012) undergoing CABG within 3 weeks of ACS were included...
July 24, 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/28737196/-results-of-a-national-program-of-pediatric-heart-transplantation-strengths-and-weakness
#17
Pedro Becker, Santiago Besa, Sergio Riveros, Rodrigo González, Alfonso Navia, Paulina Dellepiane, Daniel Springmuller, Gonzalo Urcelay
Pediatric heart transplantation is an effective therapy to treat advanced heart failure in children. OBJECTIVES: To analyze the immediate and mid-term results of pediatric patients listed for heart transplantation. PATIENTS AND METHODS: Registration of patients admitted to our transplant protocol between October 2001 and July 2016 were reviewed, analyzing demographic data, diagnosis, status at the time of listing, waiting time until transplantation, donor data, use of ventricular assist device, hemodynamic data, complications and global mortality...
June 2017: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/28737155/dawestrema-cycloancistrium-monogenea-from-the-head-pores-of-arapaimas
#18
Cláudia Portes Santos, Maralina Torres da Silva, Franti Ek Moravec
Arapaima gigas is one of the main cultured fish species in South America, and monogenean parasites of this species cause large economic losses to fish farmers. During surveys of the parasites of cultured arapaimas from Mexiana Island in the Amazon River Delta, Rio Branco, in northwestern Brazilian Amazonia, and Yurimaguas, Peru, the monogenean Dawestrema cycloancistrium was found in the gills of A. gigas as well as in previously unreported sites, i.e. the head pores and chambers. The aim of this study was to investigate the transmission route of this parasite and its geographical distribution as well as to describe its morphology as observed by light and confocal imaging...
July 24, 2017: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/28737116/apoptotic-induction-induces-leishmania-aethiopica-and-l-mexicana-spreading-in-terminally-differentiated-thp-1-cells
#19
Rajeev Rai, Paul Dyer, Simon Richardson, Laurence Harbige, Giulia Getti
Leishmaniasis develops after parasites establish themselves as amastigotes inside mammalian cells and start replicating. As relatively few parasites survive the innate immune defence, intracellular amastigotes spreading towards uninfected cells is instrumental to disease progression. Nevertheless the mechanism of Leishmania dissemination remains unclear, mostly due to the lack of a reliable model of infection spreading. Here, an in vitro model representing the dissemination of Leishmania amastigotes between human macrophages has been developed...
July 24, 2017: Parasitology
https://www.readbyqxmd.com/read/28736964/exceptionalism-is-not-exceptional-in-relation-to-sexual-and-reproduction-mechanisms-contrasts-of-human-and-animal-sexuality
#20
REVIEW
Roy J Levin
Speculation that the release of oxytocin by orgasm in the human female during coitus facilitates fertility by enhancing uterine sperm transport has been criticised as having no unequivocal empirical human evidence. However, a counter claim that this supports human 'exceptionalism' as some form of uterine sperm transport occurs in other species. This is a misconception as it ignores that human uterine peristalsis, powered by contractions of the smooth muscle of the archimyometrium, facilitates sperm transport even without any systemic oxytocin involvement...
July 24, 2017: Clinical Anatomy
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