keyword
MENU ▼
Read by QxMD icon Read
search

Ageing research

keyword
https://www.readbyqxmd.com/read/28941378/associations-among-adolescent-sleep-problems-emotion-regulation-and-affective-disorders-findings-from-a-nationally-representative-sample
#1
Cara A Palmer, Benjamin Oosterhoff, Joanne L Bower, Julie B Kaplow, Candice A Alfano
Sleep problems in youth reliably forecast the development of anxiety and mood disorders, presumably due to increased emotional difficulties. However, precise emotional mechanisms have yet to be delineated. The current study investigated how sleep problems in adolescence are associated with different emotion regulation strategies, and how sleep and psychiatric risk may be indirectly associated via poor emotion regulation. This study utilized data from the National Comorbidity Survey-Adolescent Supplement, a nationally representative sample from the United States (N = 10,148; age range 13-18 years)...
September 18, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28938749/the-testicular-transcriptome-associated-with-spermatogonia-differentiation-initiated-by-gonadotrophin-stimulation-in-the-juvenile-rhesus-monkey-macaca-mulatta
#2
Suresh Ramaswamy, William H Walker, Paula Aliberti, Rahil Sethi, Gary R Marshall, Alyxzandria Smith, Seyedmehdi Nourashrafeddin, Alicia Belgorosky, Uma R Chandran, Mark P Hedger, Tony M Plant
STUDY QUESTION: What is the genetic landscape within the testis of the juvenile rhesus monkey (Macaca mulatta) that underlies the decision of undifferentiated spermatogonia to commit to a pathway of differentiation when puberty is induced prematurely by exogenous LH and FSH stimulation? SUMMARY ANSWER: Forty-eight hours of gonadotrophin stimulation of the juvenile monkey testis resulted in the appearance of differentiating B spermatogonia and the emergence of 1362 up-regulated and 225 down-regulated testicular mRNAs encoding a complex network of proteins ranging from enzymes regulating Leydig cell steroidogenesis to membrane receptors, and from juxtacrine and paracrine factors to transcriptional factors governing spermatogonial stem cell fate...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28938748/random-start-ovarian-stimulation-for-fertility-preservation-appears-unlikely-to-delay-initiation-of-neoadjuvant-chemotherapy-for-breast-cancer
#3
Joseph M Letourneau, Nikita Sinha, Kaitlyn Wald, Eve Harris, Molly Quinn, Tal Imbar, Evelyn Mok-Lin, A Jo Chien, Mitchell Rosen
STUDY QUESTION: Is random start ovarian stimulation associated with delays in initiation of neoadjuvant chemotherapy for breast cancer? SUMMARY ANSWER: Among women who complete fertility preservation (FP) consultation, random start ovarian stimulation is unlikely to delay time to initiation of neoadjuvant chemotherapy start. WHAT IS KNOWN ALREADY: Neoadjuvant chemotherapy is now a widely accepted treatment modality for operable breast cancer and random start ovarian stimulation is an increasingly-utilized modality for FP...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28938738/resolution-of-infertility-and-number-of-children-1386-couples-followed-for-a-median-of-13-years
#4
A A Righarts, A Gray, N P Dickson, L Parkin, W R Gillett
STUDY QUESTION: How common were children among infertile couples? SUMMARY ANSWER: A total of 61.7% of infertile couples presenting for care subsequently had live born children 13.1 years after first being clinically assessed, with a mean of 1.7 children among those who had at least one. WHAT IS KNOWN ALREADY: While the prognoses for infertile couples undertaking specific treatments have been well described, less is known about those not undergoing these treatments or the total number of children...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28938736/deep-sequencing-shows-that-oocytes-are-not-prone-to-accumulate-mtdna-heteroplasmic-mutations-during-ovarian-ageing
#5
L Boucret, C Bris, V Seegers, D Goudenège, V Desquiret-Dumas, M Domin-Bernhard, V Ferré-L'Hotellier, P E Bouet, P Descamps, P Reynier, V Procaccio, P May-Panloup
STUDY QUESTION: Does ovarian ageing increase the number of heteroplasmic mitochondrial DNA (mtDNA) point mutations in oocytes? SUMMARY ANSWER: Our results suggest that oocytes are not subject to the accumulation of mtDNA point mutations during ovarian ageing. WHAT IS KNOWN ALREADY: Ageing is associated with the alteration of mtDNA integrity in various tissues. Primary oocytes, present in the ovary since embryonic life, may accumulate mtDNA mutations during the process of ovarian ageing...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28938735/the-age-of-fathers-in-the-usa-is-rising-an-analysis-of-168-867-480-births-from-1972-to-2015
#6
Yash S Khandwala, Chiyuan A Zhang, Ying Lu, Michael L Eisenberg
STUDY QUESTION: How has the mean paternal age in the USA changed over the past 4 decades? SUMMARY ANSWER: The age at which men are fathering children in the USA has been increasing over time, although it varies by race, geographic region and paternal education level. WHAT IS KNOWN ALREADY: While the rise in mean maternal age and its implications for fertility, birth outcomes and public health have been well documented, little is known about paternal characteristics of births within the USA...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28938578/quantitative-dot-blot-analysis-qdb-a-versatile-high-throughput-immunoblot-method
#7
Geng Tian, Fangrong Tang, Chunhua Yang, Wenfeng Zhang, Jonas Bergquist, Bin Wang, Jia Mi, Jiandi Zhang
Lacking access to an affordable method of high throughput immunoblot analysis for daily use remains a big challenge for scientists worldwide. We proposed here Quantitative Dot Blot analysis (QDB) to meet this demand. With the defined linear range, QDB analysis fundamentally transforms traditional immunoblot method into a true quantitative assay. Its convenience in analyzing large number of samples also enables bench scientists to examine protein expression levels from multiple parameters. In addition, the small amount of sample lysates needed for analysis means significant saving in research sources and efforts...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938275/inpatient-treatment-of-patients-admitted-for-dizziness-a-population-based-healthcare-research-study-on-epidemiology-diagnosis-treatment-and-outcome
#8
Vera Renner, Katharina Geißler, Daniel Boeger, Jens Buentzel, Dirk Esser, Kerstin Hoffmann, Peter Jecker, Andreas Mueller, Gerald Radtke, Hubertus Axer, Orlando Guntinas-Lichius
OBJECTIVE: To determine inpatient treatment rates of patients with dizziness with focus on diagnostics, treatment and outcome. STUDY DESIGN: Retrospective population-based study. SETTING: Inpatients in the federal state Thuringia in 2014. PATIENTS: All 1,262 inpatients (62% females, median age: 61 yr) treated for inpatient dizziness were included. MAIN OUTCOME MEASURES: The association between analyzed parameters and probability of improvement and recovery was tested using univariable and multivariable statistics...
September 21, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28938270/bariatric-surgery-and-the-risk-of-cancer-in-a-large-multisite-cohort
#9
Daniel P Schauer, Heather Spencer Feigelson, Corinna Koebnick, Bette Caan, Sheila Weinmann, Anthony C Leonard, J David Powers, Panduranga R Yenumula, David E Arterburn
OBJECTIVE: To determine whether bariatric surgery is associated with a lower risk of cancer. BACKGROUND: Obesity is strongly associated with many types of cancer. Few studies have examined the relationship between bariatric surgery and cancer risk. METHODS: We conducted a retrospective cohort study of patients undergoing bariatric surgery between 2005 and 2012 with follow-up through 2014 using data from a large integrated health insurance and care delivery systems with 5 study sites...
September 21, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28938248/a-youth-compendium-of-physical-activities-activity-codes-and-metabolic-intensities
#10
Nancy F Butte, Kathleen B Watson, Kate Ridley, Issa F Zakeri, Robert G McMurray, Karin A Pfeiffer, Scott E Crouter, Stephen D Herrmann, David R Bassett, Alexander Long, Zekarias Berhane, Stewart G Trost, Barbara E Ainsworth, David Berrigan, Janet E Fulton
PURPOSE: A Youth Compendium of Physical Activities (Youth Compendium) was developed to estimate the energy costs of physical activities using data on youth only. METHODS: Based on a literature search and pooled data of energy expenditure measurements in youth, the energy costs of 196 activities were compiled in 16 activity categories to form a Youth Compendium of Physical Activities. To estimate the intensity of each activity, measured oxygen consumption (V[Combining Dot Above]O2) was divided by basal metabolic rate (Schofield age-, sex- and mass-specific equations) to produce a youth MET (METy)...
September 21, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28938218/late-life-suicide-prevention-strategies-current-status-and-future-directions
#11
REVIEW
Kim Van Orden, Charlene Deming
Late life suicide prevention differs from suicide prevention for other age groups: first, the number of older adults worldwide is on the rise; second, late-life suicide receives much less attention in all societal spheres, from the media, to federal funding agencies, to healthcare initiatives. Recent findings indicate an association between internalized ageist stereotypes and reduced will to live. Recent research also addresses the role of cognitive control as a contributor to risk and as an intervention target (e...
September 8, 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/28938183/age-trends-in-rates-of-substance-use-disorders-across-ages-18-90-differences-by-gender-and-race-ethnicity
#12
Sara A Vasilenko, Rebecca J Evans-Polce, Stephanie T Lanza
BACKGROUND: Although research has documented age differences in substance use, less is known about how prevalence of substance use disorders (SUDs) vary across age and differ by gender and race/ethnicity. METHODS: Time-varying effect models (TVEMs) were estimated on data from the National Epidemiologic Survey of Alcohol and Related Conditions-III (NESARC III; N=36,309), a nationally representative survey of the adult population. The sample was 44% male; 53% White, 21% Black, 19% Hispanic/Latino, 6% other race/ethnicity...
September 14, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28938088/small-molecule-inhibitors-targeting-dna-repair-and-dna-repair-deficiency-in-research-and-cancer-therapy
#13
REVIEW
Sarah R Hengel, M Ashley Spies, Maria Spies
To maintain stable genomes and to avoid cancer and aging, cells need to repair a multitude of deleterious DNA lesions, which arise constantly in every cell. Processes that support genome integrity in normal cells, however, allow cancer cells to develop resistance to radiation and DNA-damaging chemotherapeutics. Chemical inhibition of the key DNA repair proteins and pharmacologically induced synthetic lethality have become instrumental in both dissecting the complex DNA repair networks and as promising anticancer agents...
September 21, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/28938015/non-pharmacological-treatment-for-depressed-older-patients-in-primary-care-a-systematic-review-and-meta-analysis
#14
Floor Holvast, Btissame Massoudi, Richard C Oude Voshaar, Peter F M Verhaak
BACKGROUND: Late-life depression is most often treated in primary care, and it usually coincides with chronic somatic diseases. Given that antidepressants contribute to polypharmacy in these patients, and potentially to interactions with other drugs, non-pharmacological treatments are essential. In this systematic review and meta-analysis, we aimed to present an overview of the non-pharmacological treatments available in primary care for late-life depression. METHOD: The databases of PubMed, PsychINFO, and the Cochrane Central Register of Controlled Trials were systematically searched in January 2017 with combinations of MeSH-terms and free text words for "general practice," "older adults," "depression," and "non-pharmacological treatment"...
2017: PloS One
https://www.readbyqxmd.com/read/28938004/predictive-models-of-objective-oropharyngeal-osa-surgery-outcomes-success-rate-and-ahi-reduction-ratio
#15
Ji Ho Choi, Jae Yong Lee, Jaehyung Cha, Kangwoo Kim, Seung-No Hong, Seung Hoon Lee
OBJECTIVE: The aim of this study was to develop a predictive model of objective oropharyngeal obstructive sleep apnea (OSA) surgery outcomes including success rate and apnea-hypopnea index (AHI) reduction ratio in adult OSA patients. STUDY DESIGN: Retrospective outcome research. METHODS: All subjects with OSA who underwent oropharyngeal and/or nasal surgery and were followed for at least 3 months were enrolled in this study. Demographic, anatomical [tonsil size (TS) and palate-tongue position (PTP) grade (Gr)], and polysomnographic parameters were analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/28937935/the-impact-of-the-2006-massachusetts-health-care-reform-law-on-spine-surgery-patient-payer-mix-status-and-age
#16
Nicolas W Villelli, Hong Yan, Jian Zou, Nicholas M Barbaro
OBJECTIVE Several similarities exist between the Massachusetts health care reform law of 2006 and the Affordable Care Act (ACA). The authors' prior neurosurgical research showed a decrease in uninsured surgeries without a significant change in surgical volume after the Massachusetts reform. An analysis of the payer-mix status and the age of spine surgery patients, before and after the policy, should provide insight into the future impact of the ACA on spine surgery in the US. METHODS Using the Massachusetts State Inpatient Database and spine ICD-9-CM procedure codes, the authors obtained demographic information on patients undergoing spine surgery between 2001 and 2012...
September 15, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28937865/recall-of-the-real-cost-anti-smoking-campaign-is-specifically-associated-with-endorsement-of-campaign-targeted-beliefs
#17
Elissa C Kranzler, Laura A Gibson, Robert C Hornik
Though previous research suggests the FDA's "The Real Cost" anti-smoking campaign has reduced smoking initiation, the theorized pathway of effects (through targeted beliefs) has not been evaluated. This study assesses the relationship between recall of campaign television advertisements and ad-specific anti-smoking beliefs. Respondents in a nationally representative survey of nonsmoking youths age 13-17 (n = 4,831) reported exposure to four The Real Cost advertisements and a fake ad, smoking-relevant beliefs, and nonsmoking intentions...
September 22, 2017: Journal of Health Communication
https://www.readbyqxmd.com/read/28937861/increased-suicides-during-new-year-but-not-during-christmas-in-sweden-analysis-of-cause-of-death-data-2006-2015
#18
Gergö Hadlaczky, Sebastian Hökby
BACKGROUND: Previous studies have investigated the impact of the Christmas and New Year holiday on suicide rates. However, no such data has yet been published on Swedish suicides. AIMS: To examine the occurrence of suicides on these dates in Sweden between 2006 and 2015. METHODS: The suicide count for each date between December 15th and January 15th was obtained from the Swedish cause of death registry. The observations were transformed to Z-scores to enable calculation of p-values...
September 22, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/28937834/a-child-centered-method-of-interviewing-children-with-movement-impairments
#19
Parimala S Kanagasabai, Brigit Mirfin-Veitch, Leigh A Hale, Hilda Mulligan
AIMS: Children are increasingly included in qualitative research and new methods for interviewing children are emerging. The aim of this article is to describe and discuss the strategies of a child-centered method of data collection for interviewing children with movement impairments to explore their leisure participation experiences. METHODS: A study was conducted using an Interpretative Phenomenological Approach (IPA) to explore leisure participation experiences of children with movement impairments aged 6 to 12 years...
September 22, 2017: Physical & Occupational Therapy in Pediatrics
https://www.readbyqxmd.com/read/28937790/the-doctor-of-philosophy-experience-of-athletic-trainers-facilitators-and-barriers-to-anticipatory-faculty-socialization
#20
Thomas Bowman, Joanne Klossner, Stephanie Mazerolle
CONTEXT:   It is important to understand the process whereby athletic trainers learn about their future roles, particularly when the roles can be complex and demanding. Little is known about the experiences of athletic training doctoral students, including facilitators and barriers to socialization as aspiring faculty members. OBJECTIVE:   To investigate factors influencing the anticipatory socialization of athletic training doctoral students into future faculty roles...
September 22, 2017: Journal of Athletic Training
keyword
keyword
59584
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"