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david j chen

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https://www.readbyqxmd.com/read/28091575/development-and-evaluation-of-a-high-density-genotyping-axiom_arachis-array-with-58%C3%A2-k-snps-for-accelerating-genetics-and-breeding-in-groundnut
#1
Manish K Pandey, Gaurav Agarwal, Sandip M Kale, Josh Clevenger, Spurthi N Nayak, Manda Sriswathi, Annapurna Chitikineni, Carolina Chavarro, Xiaoping Chen, Hari D Upadhyaya, Manish K Vishwakarma, Soraya Leal-Bertioli, Xuanqiang Liang, David J Bertioli, Baozhu Guo, Scott A Jackson, Peggy Ozias-Akins, Rajeev K Varshney
Single nucleotide polymorphisms (SNPs) are the most abundant DNA sequence variation in the genomes which can be used to associate genotypic variation to the phenotype. Therefore, availability of a high-density SNP array with uniform genome coverage can advance genetic studies and breeding applications. Here we report the development of a high-density SNP array 'Axiom_Arachis' with 58 K SNPs and its utility in groundnut genetic diversity study. In this context, from a total of 163,782 SNPs derived from DNA resequencing and RNA-sequencing of 41 groundnut accessions and wild diploid ancestors, a total of 58,233 unique and informative SNPs were selected for developing the array...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28090586/holliday-junction-trap-shows-how-cells-use-recombination-and-a-junction-guardian-role-of-recq-helicase
#2
Jun Xia, Li-Tzu Chen, Qian Mei, Chien-Hui Ma, Jennifer A Halliday, Hsin-Yu Lin, David Magnan, John P Pribis, Devon M Fitzgerald, Holly M Hamilton, Megan Richters, Ralf B Nehring, Xi Shen, Lei Li, David Bates, P J Hastings, Christophe Herman, Makkuni Jayaram, Susan M Rosenberg
DNA repair by homologous recombination (HR) underpins cell survival and fuels genome instability, cancer, and evolution. However, the main kinds and sources of DNA damage repaired by HR in somatic cells and the roles of important HR proteins remain elusive. We present engineered proteins that trap, map, and quantify Holliday junctions (HJs), a central DNA intermediate in HR, based on catalytically deficient mutant RuvC protein of Escherichia coli. We use RuvCDefGFP (RDG) to map genomic footprints of HR at defined DNA breaks in E...
November 2016: Science Advances
https://www.readbyqxmd.com/read/28089569/prevention-of-dietary-fat-fueled-ketogenesis-attenuates-braf-v600e-tumor-growth
#3
Siyuan Xia, Ruiting Lin, Lingtao Jin, Liang Zhao, Hee-Bum Kang, Yaozhu Pan, Shuangping Liu, Guoqing Qian, Zhiyu Qian, Evmorfia Konstantakou, Baotong Zhang, Jin-Tang Dong, Young Rock Chung, Omar Abdel-Wahab, Taha Merghoub, Lu Zhou, Ragini R Kudchadkar, David H Lawson, Hanna J Khoury, Fadlo R Khuri, Lawrence H Boise, Sagar Lonial, Benjamin H Lee, Brian P Pollack, Jack L Arbiser, Jun Fan, Qun-Ying Lei, Jing Chen
Lifestyle factors, including diet, play an important role in the survival of cancer patients. However, the molecular mechanisms underlying pathogenic links between diet and particular oncogenic mutations in human cancers remain unclear. We recently reported that the ketone body acetoacetate selectively enhances BRAF V600E mutant-dependent MEK1 activation in human cancers. Here we show that a high-fat ketogenic diet increased serum levels of acetoacetate, leading to enhanced tumor growth potential of BRAF V600E-expressing human melanoma cells in xenograft mice...
January 9, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28079189/maintenance-and-representation-of-mind-wandering-during-resting-state-fmri
#4
Ying-Hui Chou, Mark Sundman, Heather E Whitson, Pooja Gaur, Mei-Lan Chu, Carol P Weingarten, David J Madden, Lihong Wang, Imke Kirste, Marc Joliot, Michele T Diaz, Yi-Ju Li, Allen W Song, Nan-Kuei Chen
Major advances in resting-state functional magnetic resonance imaging (fMRI) techniques in the last two decades have provided a tool to better understand the functional organization of the brain both in health and illness. Despite such developments, characterizing regulation and cerebral representation of mind wandering, which occurs unavoidably during resting-state fMRI scans and may induce variability of the acquired data, remains a work in progress. Here, we demonstrate that a decrease or decoupling in functional connectivity involving the caudate nucleus, insula, medial prefrontal cortex and other domain-specific regions was associated with more sustained mind wandering in particular thought domains during resting-state fMRI...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28077676/a-ptk7-targeted-antibody-drug-conjugate-reduces-tumor-initiating-cells-and-induces-sustained-tumor-regressions
#5
Marc Damelin, Alexander Bankovich, Jeffrey Bernstein, Justin Lucas, Liang Chen, Samuel Williams, Albert Park, Jorge Aguilar, Elana Ernstoff, Manoj Charati, Russell Dushin, Monette Aujay, Christina Lee, Hanna Ramoth, Milly Milton, Johannes Hampl, Sasha Lazetic, Virginia Pulito, Edward Rosfjord, Yongliang Sun, Lindsay King, Frank Barletta, Alison Betts, Magali Guffroy, Hadi Falahatpisheh, Christopher J O'Donnell, Robert Stull, Marybeth Pysz, Paul Escarpe, David Liu, Orit Foord, Hans Peter Gerber, Puja Sapra, Scott J Dylla
Disease relapse after treatment is common in triple-negative breast cancer (TNBC), ovarian cancer (OVCA), and non-small cell lung cancer (NSCLC). Therapies that target tumor-initiating cells (TICs) should improve patient survival by eliminating the cells that can drive tumor recurrence and metastasis. We demonstrate that protein tyrosine kinase 7 (PTK7), a highly conserved but catalytically inactive receptor tyrosine kinase in the Wnt signaling pathway, is enriched on TICs in low-passage TNBC, OVCA, and NSCLC patient-derived xenografts (PDXs)...
January 11, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28074934/disease-modifying-effect-of-intravenous-immunoglobulin-in-an-experimental-model-of-epilepsy
#6
Min Chen, Thiruma V Arumugam, Gayeshika Leanage, Quang M Tieng, Ashwin Yadav, Jeremy F P Ullmann, David T She, Vy Truong, Marc J Ruitenberg, David C Reutens
Novel therapies that prevent or modify the development of epilepsy following an initiating brain insult could significantly reduce the burden of this disease. In light of evidence that immune mechanisms play an important role in generating and maintaining the epileptic condition, we evaluated the effect of a well-established immunomodulatory treatment, intravenous immunoglobulin (IVIg), on the development of epilepsy in an experimental model of epileptogenesis. In separate experiments, IVIg was administered either before (pre-treatment) or after (post-treatment) the onset of pilocarpine status epilepticus (SE)...
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28071976/precise-flexible-and-affordable-gene-stacking-for-crop-improvement
#7
Weiqiang Chen, David W Ow
Addendum to: Hou L, Yau YY, Wei J, Han Z, Dong Z, Ow DW. An open-source system for in planta gene stacking by Bxb1 and Cre recombinases. Mol Plant, 2014; 7(12):1756-1765. doi:10.1093/mp/ssu107; Li R, Han Z, Hou L, Kaur G, Yin Q, Ow DW. Method for Biolistic Site-Specific Integration in Plants Catalyzed by Bxb1 Integrase. In: Murata M, editor. Chromosome and Genomic Engineering in Plants: Methods and Protocols, Methods in Molecular Biology. 2016; p.15-30; and Chen W, Ow DW. Protocol for In Vitro Stacked Molecules Compatible with In Vivo Recombinase-Mediated Gene Stacking...
January 10, 2017: Bioengineered
https://www.readbyqxmd.com/read/28065902/princess-privacy-protecting-rare-disease-international-network-collaboration-via-encryption-through-software-guard-extensions
#8
Feng Chen, Shuang Wang, Xiaoqian Jiang, Sijie Ding, Yao Lu, Jihoon Kim, S Cenk Sahinalp, Chisato Shimizu, Jane C Burns, Victoria J Wright, Eileen Png, Martin L Hibberd, David D Lloyd, Hai Yang, Amalio Telenti, Cinnamon S Bloss, Dov Fox, Kristin Lauter, Lucila Ohno-Machado
MOTIVATION: We introduce PRINCESS, a privacy-preserving international collaboration framework for analyzing rare disease genetic data that are distributed across different continents. PRINCESS leverages Software Guard Extensions (SGX) and hardware for trustworthy computation. Unlike a traditional international collaboration model, where individual-level patient DNA are physically centralized at a single site, PRINCESS performs a secure and distributed computation over encrypted data, fulfilling institutional policies and regulations for protected health information...
January 8, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28064433/magnetic-vt-study-a-prospective-multicenter-post-market-randomized-controlled-trial-comparing-vt-ablation-outcomes-using-remote-magnetic-navigation-guided-substrate-mapping-and-ablation-versus-manual-approach-in-a-low-lvef-population
#9
Luigi Di Biase, Roderick Tung, Tamás Szili-Torok, J David Burkhardt, Peter Weiss, Rene Tavernier, Adam E Berman, Erik Wissner, William Spear, Xu Chen, Petr Neužil, Jan Skoda, Dhanunjaya Lakkireddy, Bruno Schwagten, Ken Lock, Andrea Natale
PURPOSE: Patients with ischemic cardiomyopathy (ICM) are prone to scar-related ventricular tachycardia (VT). The success of VT ablation depends on accurate arrhythmogenic substrate localization, followed by optimal delivery of energy provided by constant electrode-tissue contact. Current manual and remote magnetic navigation (RMN)-guided ablation strategies aim to identify a reentry circuit and to target a critical isthmus through activation and entrainment mapping during ongoing tachycardia...
January 7, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/28064115/do-social-functioning-and-symptoms-improve-with-continuation-antidepressant-treatment-of-persistent-depressive-disorder-an-observational-study
#10
David J Hellerstein, Kallio Hunnicutt-Ferguson, Jonathan W Stewart, Patrick J McGrath, Samantha Keller, Bradley S Peterson, Ying Chen
OBJECTIVE: To determine efficacy of continued treatment with the serotonin norepinephrine reuptake inhibitor duloxetine on symptom reduction and functional improvement in outpatients with dysthymia. METHOD: Fifty outpatients with DSM-IV-TR diagnosed dysthymia who had participated in a 10 week double-blind, placebo-controlled study of duloxetine received open treatment for three months. Nineteen duloxetine responders continued duloxetine, 24 patients initially treated with placebo started open duloxetine treatment, and 7 duloxetine non-responders were treated with desvenlafaxine or bupropion, selected by clinician choice...
December 20, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28062664/mapping-eqtls-with-rna-seq-reveals-novel-susceptibility-genes-non-coding-rnas-and-alternative-splicing-events-in-systemic-lupus-erythematosus
#11
Christopher A Odhams, Andrea Cortini, Lingyan Chen, Amy L Roberts, Ana Viñuela, Alfonso Buil, Kerrin S Small, Emmanouil T Dermitzakis, David L Morris, Timothy J Vyse, Deborah S Cunninghame Graham
Studies attempting to functionally interpret complex-disease susceptibility loci by GWAS and eQTL integration have predominantly employed microarrays to quantify gene-expression. RNA-Seq has the potential to discover a more comprehensive set of eQTLs and illuminate the underlying molecular consequence. We examine the functional outcome of 39 variants associated with Systemic Lupus Erythematosus (SLE) through integration of GWAS and eQTL data from the TwinsUK microarray and RNA-Seq cohort in lymphoblastoid cell lines...
January 5, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28061857/coordinated-regulation-of-acid-resistance-in-escherichia-coli
#12
Patricia Aquino, Brent Honda, Suma Jaini, Anna Lyubetskaya, Krutika Hosur, Joanna G Chiu, Iriny Ekladious, Dongjian Hu, Lin Jin, Marianna K Sayeg, Arion I Stettner, Julia Wang, Brandon G Wong, Winnie S Wong, Stephen L Alexander, Cong Ba, Seth I Bensussen, David B Bernstein, Dana Braff, Susie Cha, Daniel I Cheng, Jang Hwan Cho, Kenny Chou, James Chuang, Daniel E Gastler, Daniel J Grasso, John S Greifenberger, Chen Guo, Anna K Hawes, Divya V Israni, Saloni R Jain, Jessica Kim, Junyu Lei, Hao Li, David Li, Qian Li, Christopher P Mancuso, Ning Mao, Salwa F Masud, Cari L Meisel, Jing Mi, Christine S Nykyforchyn, Minhee Park, Hannah M Peterson, Alfred K Ramirez, Daniel S Reynolds, Nae Gyune Rim, Jared C Saffie, Hang Su, Wendell R Su, Yaqing Su, Meng Sun, Meghan M Thommes, Tao Tu, Nitinun Varongchayakul, Tyler E Wagner, Benjamin H Weinberg, Rouhui Yang, Anastasia Yaroslavsky, Christine Yoon, Yanyu Zhao, Alicia J Zollinger, Anne M Stringer, John W Foster, Joseph Wade, Sahadaven Raman, Natasha Broude, Wilson W Wong, James E Galagan
BACKGROUND: Enteric Escherichia coli survives the highly acidic environment of the stomach through multiple acid resistance (AR) mechanisms. The most effective system, AR2, decarboxylates externally-derived glutamate to remove cytoplasmic protons and excrete GABA. The first described system, AR1, does not require an external amino acid. Its mechanism has not been determined. The regulation of the multiple AR systems and their coordination with broader cellular metabolism has not been fully explored...
January 6, 2017: BMC Systems Biology
https://www.readbyqxmd.com/read/28061024/beyond-the-code-a-guide-to-the-description-and-documentation-of-biodiversity-in-ciliated-protists-alveolata-ciliophora
#13
Alan Warren, David J Patterson, Micah Dunthorn, John C Clamp, Undine E M Achilles-Day, Erna Aescht, Saleh A Al-Farraj, Saleh Al-Quraishy, Khaled Al-Rasheid, Martin Carr, John G Day, Marc Dellinger, Hamed A El-Serehy, Yangbo Fan, Feng Gao, Shan Gao, Jun Gong, Renu Gupta, Xiaozhong Hu, Komal Kamra, Gaytha Langlois, Xiaofeng Lin, Diana Lipscomb, Christopher S Lobban, Pierangelo Luporini, Denis H Lynn, Honggang Ma, Miroslav Macek, Jacqueline Mackenzie-Dodds, Seema Makhija, Robert I Mansergh, Mercedes Martín-Cereceda, Nettie McMiller, David J S Montagnes, Nikolaeva Svetlana, Geoffrey Odhiambo Ong'ondo, Blanca Pérez-Uz, Jasmine Purushothaman, Pablo Quintela-Alonso, Johana Rotterová, Luciana Santoferrara, Chen Shao, Zhuo Shen, Xinlu Shi, Weibo Song, Thorsten Stoeck, Antonietta La Terza, Adriana Vallesi, Mei Wang, Thomas Weisse, Krzysztof Wiackowski, Lei Wu, Kuidong Xu, Zhenzhen Yi, Rebecca Zufall, Sabine Agatha
Recent advances in molecular technology have revolutionized research on all aspects of the biology of organisms, including ciliates, and created unprecedented opportunities for pursuing a more integrative approach to investigation of biodiversity. However, this goal is complicated by large gaps and inconsistencies that still exist in the foundation of basic information about biodiversity of ciliates. The present paper reviews issues relating to the taxonomy of ciliates and presents specific recommendations for best practice in the observation and documentation of their biodiversity...
January 6, 2017: Journal of Eukaryotic Microbiology
https://www.readbyqxmd.com/read/28059768/sox2-promotes-lineage-plasticity-and-antiandrogen-resistance-in-tp53-and-rb1-deficient-prostate-cancer
#14
Ping Mu, Zeda Zhang, Matteo Benelli, Wouter R Karthaus, Elizabeth Hoover, Chi-Chao Chen, John Wongvipat, Sheng-Yu Ku, Dong Gao, Zhen Cao, Neel Shah, Elizabeth J Adams, Wassim Abida, Philip A Watson, Davide Prandi, Chun-Hao Huang, Elisa de Stanchina, Scott W Lowe, Leigh Ellis, Himisha Beltran, Mark A Rubin, David W Goodrich, Francesca Demichelis, Charles L Sawyers
Some cancers evade targeted therapies through a mechanism known as lineage plasticity, whereby tumor cells acquire phenotypic characteristics of a cell lineage whose survival no longer depends on the drug target. We use in vitro and in vivo human prostate cancer models to show that these tumors can develop resistance to the antiandrogen drug enzalutamide by a phenotypic shift from androgen receptor (AR)-dependent luminal epithelial cells to AR-independent basal-like cells. This lineage plasticity is enabled by the loss of TP53 and RB1 function, is mediated by increased expression of the reprogramming transcription factor SOX2, and can be reversed by restoring TP53 and RB1 function or by inhibiting SOX2 expression...
January 6, 2017: Science
https://www.readbyqxmd.com/read/28059544/measurement-of-cp-violation-in-b-0-%C3%A2-d-d-decays
#15
R Aaij, B Adeva, M Adinolfi, Z Ajaltouni, S Akar, J Albrecht, F Alessio, M Alexander, S Ali, G Alkhazov, P Alvarez Cartelle, A A Alves, S Amato, S Amerio, Y Amhis, L An, L Anderlini, G Andreassi, M Andreotti, J E Andrews, R B Appleby, F Archilli, P d'Argent, J Arnau Romeu, A Artamonov, M Artuso, E Aslanides, G Auriemma, M Baalouch, I Babuschkin, S Bachmann, J J Back, A Badalov, C Baesso, S Baker, W Baldini, R J Barlow, C Barschel, S Barsuk, W Barter, M Baszczyk, V Batozskaya, B Batsukh, V Battista, A Bay, L Beaucourt, J Beddow, F Bedeschi, I Bediaga, L J Bel, V Bellee, N Belloli, K Belous, I Belyaev, E Ben-Haim, G Bencivenni, S Benson, J Benton, A Berezhnoy, R Bernet, A Bertolin, F Betti, M-O Bettler, M van Beuzekom, Ia Bezshyiko, S Bifani, P Billoir, T Bird, A Birnkraut, A Bitadze, A Bizzeti, T Blake, F Blanc, J Blouw, S Blusk, V Bocci, T Boettcher, A Bondar, N Bondar, W Bonivento, A Borgheresi, S Borghi, M Borisyak, M Borsato, F Bossu, M Boubdir, T J V Bowcock, E Bowen, C Bozzi, S Braun, M Britsch, T Britton, J Brodzicka, E Buchanan, C Burr, A Bursche, J Buytaert, S Cadeddu, R Calabrese, M Calvi, M Calvo Gomez, A Camboni, P Campana, D Campora Perez, D H Campora Perez, L Capriotti, A Carbone, G Carboni, R Cardinale, A Cardini, P Carniti, L Carson, K Carvalho Akiba, G Casse, L Cassina, L Castillo Garcia, M Cattaneo, Ch Cauet, G Cavallero, R Cenci, M Charles, Ph Charpentier, G Chatzikonstantinidis, M Chefdeville, S Chen, S-F Cheung, V Chobanova, M Chrzaszcz, X Cid Vidal, G Ciezarek, P E L Clarke, M Clemencic, H V Cliff, J Closier, V Coco, J Cogan, E Cogneras, V Cogoni, L Cojocariu, G Collazuol, P Collins, A Comerma-Montells, A Contu, A Cook, G Coombs, S Coquereau, G Corti, M Corvo, C M Costa Sobral, B Couturier, G A Cowan, D C Craik, A Crocombe, M Cruz Torres, S Cunliffe, R Currie, C D'Ambrosio, F Da Cunha Marinho, E Dall'Occo, J Dalseno, P N Y David, A Davis, O De Aguiar Francisco, K De Bruyn, S De Capua, M De Cian, J M De Miranda, L De Paula, M De Serio, P De Simone, C-T Dean, D Decamp, M Deckenhoff, L Del Buono, M Demmer, D Derkach, O Deschamps, F Dettori, B Dey, A Di Canto, H Dijkstra, F Dordei, M Dorigo, A Dosil Suárez, A Dovbnya, K Dreimanis, L Dufour, G Dujany, K Dungs, P Durante, R Dzhelyadin, A Dziurda, A Dzyuba, N Déléage, S Easo, M Ebert, U Egede, V Egorychev, S Eidelman, S Eisenhardt, U Eitschberger, R Ekelhof, L Eklund, Ch Elsasser, S Ely, S Esen, H M Evans, T Evans, A Falabella, N Farley, S Farry, R Fay, D Fazzini, D Ferguson, V Fernandez Albor, A Fernandez Prieto, F Ferrari, F Ferreira Rodrigues, M Ferro-Luzzi, S Filippov, R A Fini, M Fiore, M Fiorini, M Firlej, C Fitzpatrick, T Fiutowski, F Fleuret, K Fohl, M Fontana, F Fontanelli, D C Forshaw, R Forty, V Franco Lima, M Frank, C Frei, J Fu, E Furfaro, C Färber, A Gallas Torreira, D Galli, S Gallorini, S Gambetta, M Gandelman, P Gandini, Y Gao, L M Garcia Martin, J García Pardiñas, J Garra Tico, L Garrido, P J Garsed, D Gascon, C Gaspar, L Gavardi, G Gazzoni, D Gerick, E Gersabeck, M Gersabeck, T Gershon, Ph Ghez, S Gianì, V Gibson, O G Girard, L Giubega, K Gizdov, V V Gligorov, D Golubkov, A Golutvin, A Gomes, I V Gorelov, C Gotti, M Grabalosa Gándara, R Graciani Diaz, L A Granado Cardoso, E Graugés, E Graverini, G Graziani, A Grecu, P Griffith, L Grillo, B R Gruberg Cazon, O Grünberg, E Gushchin, Yu Guz, T Gys, C Göbel, T Hadavizadeh, C Hadjivasiliou, G Haefeli, C Haen, S C Haines, S Hall, B Hamilton, X Han, S Hansmann-Menzemer, N Harnew, S T Harnew, J Harrison, M Hatch, J He, T Head, A Heister, K Hennessy, P Henrard, L Henry, J A Hernando Morata, E van Herwijnen, M Heß, A Hicheur, D Hill, C Hombach, H Hopchev, W Hulsbergen, T Humair, M Hushchyn, N Hussain, D Hutchcroft, M Idzik, P Ilten, R Jacobsson, A Jaeger, J Jalocha, E Jans, A Jawahery, F Jiang, M John, D Johnson, C R Jones, C Joram, B Jost, N Jurik, S Kandybei, W Kanso, M Karacson, J M Kariuki, S Karodia, M Kecke, M Kelsey, I R Kenyon, M Kenzie, T Ketel, E Khairullin, B Khanji, C Khurewathanakul, T Kirn, S Klaver, K Klimaszewski, S Koliiev, M Kolpin, I Komarov, R F Koopman, P Koppenburg, A Kosmyntseva, A Kozachuk, M Kozeiha, L Kravchuk, K Kreplin, M Kreps, P Krokovny, F Kruse, W Krzemien, W Kucewicz, M Kucharczyk, V Kudryavtsev, A K Kuonen, K Kurek, T Kvaratskheliya, D Lacarrere, G Lafferty, A Lai, D Lambert, G Lanfranchi, C Langenbruch, T Latham, C Lazzeroni, R Le Gac, J van Leerdam, J-P Lees, A Leflat, J Lefrançois, R Lefèvre, F Lemaitre, E Lemos Cid, O Leroy, T Lesiak, B Leverington, Y Li, T Likhomanenko, R Lindner, C Linn, F Lionetto, B Liu, X Liu, D Loh, I Longstaff, J H Lopes, D Lucchesi, M Lucio Martinez, H Luo, A Lupato, E Luppi, O Lupton, A Lusiani, X Lyu, F Machefert, F Maciuc, O Maev, K Maguire, S Malde, A Malinin, T Maltsev, G Manca, G Mancinelli, P Manning, J Maratas, J F Marchand, U Marconi, C Marin Benito, P Marino, J Marks, G Martellotti, M Martin, M Martinelli, D Martinez Santos, F Martinez Vidal, D Martins Tostes, L M Massacrier, A Massafferri, R Matev, A Mathad, Z Mathe, C Matteuzzi, A Mauri, B Maurin, A Mazurov, M McCann, J McCarthy, A McNab, R McNulty, B Meadows, F Meier, M Meissner, D Melnychuk, M Merk, A Merli, E Michielin, D A Milanes, M-N Minard, D S Mitzel, A Mogini, J Molina Rodriguez, I A Monroy, S Monteil, M Morandin, P Morawski, A Mordà, M J Morello, J Moron, A B Morris, R Mountain, F Muheim, M Mulder, M Mussini, D Müller, J Müller, K Müller, V Müller, P Naik, T Nakada, R Nandakumar, A Nandi, I Nasteva, M Needham, N Neri, S Neubert, N Neufeld, M Neuner, A D Nguyen, T D Nguyen, C Nguyen-Mau, S Nieswand, R Niet, N Nikitin, T Nikodem, A Novoselov, D P O'Hanlon, A Oblakowska-Mucha, V Obraztsov, S Ogilvy, R Oldeman, C J G Onderwater, J M Otalora Goicochea, A Otto, P Owen, A Oyanguren, P R Pais, A Palano, F Palombo, M Palutan, J Panman, A Papanestis, M Pappagallo, L L Pappalardo, W Parker, C Parkes, G Passaleva, A Pastore, G D Patel, M Patel, C Patrignani, A Pearce, A Pellegrino, G Penso, M Pepe Altarelli, S Perazzini, P Perret, L Pescatore, K Petridis, A Petrolini, A Petrov, M Petruzzo, E Picatoste Olloqui, B Pietrzyk, M Pikies, D Pinci, A Pistone, A Piucci, S Playfer, M Plo Casasus, T Poikela, F Polci, A Poluektov, I Polyakov, E Polycarpo, G J Pomery, A Popov, D Popov, B Popovici, S Poslavskii, C Potterat, E Price, J D Price, J Prisciandaro, A Pritchard, C Prouve, V Pugatch, A Puig Navarro, G Punzi, W Qian, R Quagliani, B Rachwal, J H Rademacker, M Rama, M Ramos Pernas, M S Rangel, I Raniuk, G Raven, F Redi, S Reichert, A C Dos Reis, C Remon Alepuz, V Renaudin, S Ricciardi, S Richards, M Rihl, K Rinnert, V Rives Molina, P Robbe, A B Rodrigues, E Rodrigues, J A Rodriguez Lopez, P Rodriguez Perez, A Rogozhnikov, S Roiser, A Rollings, V Romanovskiy, A Romero Vidal, J W Ronayne, M Rotondo, M S Rudolph, T Ruf, P Ruiz Valls, J J Saborido Silva, E Sadykhov, N Sagidova, B Saitta, V Salustino Guimaraes, C Sanchez Mayordomo, B Sanmartin Sedes, R Santacesaria, C Santamarina Rios, M Santimaria, E Santovetti, A Sarti, C Satriano, A Satta, D M Saunders, D Savrina, S Schael, M Schellenberg, M Schiller, H Schindler, M Schlupp, M Schmelling, T Schmelzer, B Schmidt, O Schneider, A Schopper, K Schubert, M Schubiger, M-H Schune, R Schwemmer, B Sciascia, A Sciubba, A Semennikov, A Sergi, N Serra, J Serrano, L Sestini, P Seyfert, M Shapkin, I Shapoval, Y Shcheglov, T Shears, L Shekhtman, V Shevchenko, A Shires, B G Siddi, R Silva Coutinho, L Silva de Oliveira, G Simi, S Simone, M Sirendi, N Skidmore, T Skwarnicki, E Smith, I T Smith, J Smith, M Smith, H Snoek, M D Sokoloff, F J P Soler, B Souza De Paula, B Spaan, P Spradlin, S Sridharan, F Stagni, M Stahl, S Stahl, P Stefko, S Stefkova, O Steinkamp, S Stemmle, O Stenyakin, S Stevenson, S Stoica, S Stone, B Storaci, S Stracka, M Straticiuc, U Straumann, L Sun, W Sutcliffe, K Swientek, V Syropoulos, M Szczekowski, T Szumlak, S T'Jampens, A Tayduganov, T Tekampe, M Teklishyn, G Tellarini, F Teubert, E Thomas, J van Tilburg, M J Tilley, V Tisserand, M Tobin, S Tolk, L Tomassetti, D Tonelli, S Topp-Joergensen, F Toriello, E Tournefier, S Tourneur, K Trabelsi, M Traill, M T Tran, M Tresch, A Trisovic, A Tsaregorodtsev, P Tsopelas, A Tully, N Tuning, A Ukleja, A Ustyuzhanin, U Uwer, C Vacca, V Vagnoni, A Valassi, S Valat, G Valenti, A Vallier, R Vazquez Gomez, P Vazquez Regueiro, S Vecchi, M van Veghel, J J Velthuis, M Veltri, G Veneziano, A Venkateswaran, M Vernet, M Vesterinen, B Viaud, D Vieira, M Vieites Diaz, X Vilasis-Cardona, V Volkov, A Vollhardt, B Voneki, A Vorobyev, V Vorobyev, C Voß, J A de Vries, C Vázquez Sierra, R Waldi, C Wallace, R Wallace, J Walsh, J Wang, D R Ward, H M Wark, N K Watson, D Websdale, A Weiden, M Whitehead, J Wicht, G Wilkinson, M Wilkinson, M Williams, M P Williams, M Williams, T Williams, F F Wilson, J Wimberley, J Wishahi, W Wislicki, M Witek, G Wormser, S A Wotton, K Wraight, S Wright, K Wyllie, Y Xie, Z Xing, Z Xu, Z Yang, H Yin, J Yu, X Yuan, O Yushchenko, K A Zarebski, M Zavertyaev, L Zhang, Y Zhang, Y Zhang, A Zhelezov, Y Zheng, A Zhokhov, X Zhu, V Zhukov, S Zucchelli
The CP violation observables S and C in the decay channel B^{0}→D^{+}D^{-} are determined from a sample of proton-proton collisions at center-of-mass energies of 7 and 8 TeV, collected by the LHCb experiment and corresponding to an integrated luminosity of 3  fb^{-1}. The observable S describes CP violation in the interference between mixing and the decay amplitude, and C parametrizes direct CP violation in the decay. The following values are obtained from a flavor-tagged, decay-time-dependent analysis: S=-0...
December 23, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/28052456/frontoparietal-activation-during-visual-conjunction-search-effects-of-bottom-up-guidance-and-adult-age
#16
David J Madden, Emily L Parks, Catherine W Tallman, Maria A Boylan, David A Hoagey, Sally B Cocjin, Micah A Johnson, Ying-Hui Chou, Guy G Potter, Nan-Kuei Chen, Lauren E Packard, Rachel E Siciliano, Zachary A Monge, Michele T Diaz
We conducted functional magnetic resonance imaging (fMRI) with a visual search paradigm to test the hypothesis that aging is associated with increased frontoparietal involvement in both target detection and bottom-up attentional guidance (featural salience). Participants were 68 healthy adults, distributed continuously across 19 to 78 years of age. Frontoparietal regions of interest (ROIs) were defined from resting-state scans obtained prior to task-related fMRI. The search target was defined by a conjunction of color and orientation...
January 4, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28052408/relapse-risk-and-survival-in-patients-with-flt3-acute-myeloid-leukemia-undergoing-stem-cell-transplantation
#17
Sameh Gaballa, Rima Saliba, Betul Oran, Jonathan E Brammer, Julianne Chen, Gabriela Rondon, Amin M Alousi, Partow Kebriaei, David Marin, Uday R Popat, Borje S Andersson, Elizabeth J Shpall, Elias Jabbour, Naval Daver, Michael Andreeff, Farhad Ravandi, Jorge Cortes, Keyur Patel, Richard E Champlin, Stefan O Ciurea
In patients with AML with FMS-like tyrosine kinase 3 (FLT3) mutations, the significance of minimal residual disease (MRD) detected by PCR before allogeneic stem cell transplantation (SCT) on outcomes after transplant remains unclear. We identified 200 patients with FLT3-AML who underwent SCT at our institution. Disease status at transplant was: first or second complete remission (CR1/CR2, n=119), high-risk CR (third or subsequent CR, marrow hypoplasia, or incomplete count recovery) (CR-HR, n=31), and morphological evidence of active disease (AD, n=50)...
January 4, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28039329/a-genome-wide-interaction-analysis-of-tricyclic-tetracyclic-antidepressants-and-rr-and-qt-intervals-a-pharmacogenomics-study-from-the-cohorts-for-heart-and-aging-research-in-genomic-epidemiology-charge-consortium
#18
Raymond Noordam, Colleen M Sitlani, Christy L Avery, James D Stewart, Stephanie M Gogarten, Kerri L Wiggins, Stella Trompet, Helen R Warren, Fangui Sun, Daniel S Evans, Xiaohui Li, Jin Li, Albert V Smith, Joshua C Bis, Jennifer A Brody, Evan L Busch, Mark J Caulfield, Yii-Der I Chen, Steven R Cummings, L Adrienne Cupples, Qing Duan, Oscar H Franco, Rául Méndez-Giráldez, Tamara B Harris, Susan R Heckbert, Diana van Heemst, Albert Hofman, James S Floyd, Jan A Kors, Lenore J Launer, Yun Li, Ruifang Li-Gao, Leslie A Lange, Henry J Lin, Renée de Mutsert, Melanie D Napier, Christopher Newton-Cheh, Neil Poulter, Alexander P Reiner, Kenneth M Rice, Jeffrey Roach, Carlos J Rodriguez, Frits R Rosendaal, Naveed Sattar, Peter Sever, Amanda A Seyerle, P Eline Slagboom, Elsayed Z Soliman, Nona Sotoodehnia, David J Stott, Til Stürmer, Kent D Taylor, Timothy A Thornton, André G Uitterlinden, Kirk C Wilhelmsen, James G Wilson, Vilmundur Gudnason, J Wouter Jukema, Cathy C Laurie, Yongmei Liu, Dennis O Mook-Kanamori, Patricia B Munroe, Jerome I Rotter, Ramachandran S Vasan, Bruce M Psaty, Bruno H Stricker, Eric A Whitsel
BACKGROUND: Increased heart rate and a prolonged QT interval are important risk factors for cardiovascular morbidity and mortality, and can be influenced by the use of various medications, including tricyclic/tetracyclic antidepressants (TCAs). We aim to identify genetic loci that modify the association between TCA use and RR and QT intervals. METHODS AND RESULTS: We conducted race/ethnic-specific genome-wide interaction analyses (with HapMap phase II imputed reference panel imputation) of TCAs and resting RR and QT intervals in cohorts of European (n=45 706; n=1417 TCA users), African (n=10 235; n=296 TCA users) and Hispanic/Latino (n=13 808; n=147 TCA users) ancestry, adjusted for clinical covariates...
December 30, 2016: Journal of Medical Genetics
https://www.readbyqxmd.com/read/28034071/relapsed-or-refractory-double-expressor-and-double-hit-lymphomas-have-inferior-progression-free-survival-after-autologous-stem-cell-transplantation
#19
Alex F Herrera, Matthew Mei, Lawrence Low, Haesook T Kim, Gabriel K Griffin, Joo Y Song, Reid W Merryman, Victoria Bedell, Christine Pak, Heather Sun, Tanya Paris, Tracey Stiller, Jennifer R Brown, Lihua E Budde, Wing C Chan, Robert Chen, Matthew S Davids, Arnold S Freedman, David C Fisher, Eric D Jacobsen, Caron A Jacobson, Ann S LaCasce, Joyce Murata-Collins, Auayporn P Nademanee, Joycelynne M Palmer, German A Pihan, Raju Pillai, Leslie Popplewell, Tanya Siddiqi, Aliyah R Sohani, Jasmine Zain, Steven T Rosen, Larry W Kwak, David M Weinstock, Stephen J Forman, Dennis D Weisenburger, Young Kim, Scott J Rodig, Amrita Krishnan, Philippe Armand
Purpose Double-hit lymphomas (DHLs) and double-expressor lymphomas (DELs) are subtypes of diffuse large B-cell lymphoma (DLBCL) associated with poor outcomes after standard chemoimmunotherapy. Data are limited regarding outcomes of patients with relapsed or refractory (rel/ref) DEL or DHL who undergo autologous stem-cell transplantation (ASCT). We retrospectively studied the prognostic impact of DEL and DHL status on ASCT outcomes in patients with rel/ref DLBCL. Methods Patients with chemotherapy-sensitive rel/ref DLBCL who underwent ASCT at two institutions and in whom archival tumor material was available were enrolled...
January 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28032407/cyp2a6-metabolism-in-the-development-of-smoking-behaviors-in-young-adults
#20
Emily Olfson, Joseph Bloom, Sarah Bertelsen, John P Budde, Naomi Breslau, Andrew Brooks, Robert Culverhouse, Grace Chan, Li-Shiun Chen, David Chorlian, Danielle M Dick, Howard J Edenberg, Sarah Hartz, Dorothy Hatsukami, Victor M Hesselbrock, Eric O Johnson, John R Kramer, Samuel Kuperman, Jacquelyn L Meyers, John Nurnberger, Bernice Porjesz, Nancy L Saccone, Marc A Schuckit, Jerry Stitzel, Jay A Tischfield, John P Rice, Alison Goate, Laura J Bierut
Cytochrome P450 2A6 (CYP2A6) encodes the enzyme responsible for the majority of nicotine metabolism. Previous studies support that slow metabolizers smoke fewer cigarettes once nicotine dependent but provide conflicting results on the role of CYP2A6 in the development of dependence. By focusing on the critical period of young adulthood, this study examines the relationship of CYP2A6 variation and smoking milestones. A total of 1209 European American young adults enrolled in the Collaborative Study on the Genetics of Alcoholism were genotyped for CYP2A6 variants to calculate a previously well-validated metric that estimates nicotine metabolism...
December 29, 2016: Addiction Biology
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