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david j chen

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https://www.readbyqxmd.com/read/29040031/prospective-randomized-double-blind-phase-iii-clinical-trial-of-anti-t-lymphocyte-globulin-to-assess-impact-on-chronic-graft-versus-host-disease-free-survival-in-patients-undergoing-hla-matched-unrelated-myeloablative-hematopoietic-cell-transplantation
#1
Robert J Soiffer, Haesook T Kim, Joseph McGuirk, Mitchell E Horwitz, Laura Johnston, Mrinal M Patnaik, Witold Rybka, Andrew Artz, David L Porter, Thomas C Shea, Michael W Boyer, Richard T Maziarz, Paul J Shaughnessy, Usama Gergis, Hana Safah, Ran Reshef, John F DiPersio, Patrick J Stiff, Madhuri Vusirikala, Jeff Szer, Jennifer Holter, James D Levine, Paul J Martin, Joseph A Pidala, Ian D Lewis, Vincent T Ho, Edwin P Alyea, Jerome Ritz, Frank Glavin, Peter Westervelt, Madan H Jagasia, Yi-Bin Chen
Purpose Several open-label randomized studies have suggested that in vivo T-cell depletion with anti-T-lymphocyte globulin (ATLG; formerly antithymocyte globulin-Fresenius) reduces chronic graft-versus-host disease (cGVHD) without compromising survival. We report a prospective, double-blind phase III trial to investigate the effect of ATLG (Neovii Biotech, Lexington, MA) on cGVHD-free survival. Patients and Methods Two hundred fifty-four patients 18 to 65 years of age with acute leukemia or myelodysplastic syndrome who underwent myeloablative HLA-matched unrelated hematopoietic cell transplantation (HCT) were randomly assigned one to one to placebo (n =128 placebo) or ATLG (n = 126) treatment at 27 sites...
October 17, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29036586/epigenetic-mechanisms-underlie-the-crosstalk-between-growth-factors-and-a-steroid-hormone
#2
Yehoshua Enuka, Morris E Feldman, Animesh Chowdhury, Swati Srivastava, Moshit Lindzen, Aldema Sas-Chen, Renaud Massart, David Cheishvili, Matthew J Suderman, Yoav Zaltsman, Chiara A Mazza, Kirti Shukla, Cindy Körner, Noa Furth, Mattia Lauriola, Moshe Oren, Stefan Wiemann, Moshe Szyf, Yosef Yarden
Crosstalk between growth factors (GFs) and steroid hormones recurs in embryogenesis and is co-opted in pathology, but underlying mechanisms remain elusive. Our data from mammary cells imply that the crosstalk between the epidermal GF and glucocorticoids (GCs) involves transcription factors like p53 and NF-κB, along with reduced pausing and traveling of RNA polymerase II (RNAPII) at both promoters and bodies of GF-inducible genes. Essentially, GCs inhibit positive feedback loops activated by GFs and stimulate the reciprocal inhibitory loops...
September 28, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29030966/metabolic-reduction-of-resazurin-location-within-the-cell-for-cytotoxicity-assays
#3
Jian Lin Chen, Terry W J Steele, David C Stuckey
Resazurin is widely used as a metabolic indicator for living cells, however, there has been considerable debate in the literature with regards to the specific location in the cell where the non-fluorescent resazurin is reduced to the strongly fluorescent resorufin. This lack of clarity about the reduction site makes the use of resazurin reduction data in cytotoxicity studies difficult to interpret. In this study, E. faecalis, a Gram-positive and facultative anaerobic bacterial strain, and the most toxic chlorophenol, pentachlorophenol (PCP), were chosen as models for an anaerobe and toxicant, respectively...
October 14, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29029846/identification-of-novel-risk-loci-for-restless-legs-syndrome-in-genome-wide-association-studies-in-individuals-of-european-ancestry-a-meta-analysis
#4
Barbara Schormair, Chen Zhao, Steven Bell, Erik Tilch, Aaro V Salminen, Benno Pütz, Yves Dauvilliers, Ambra Stefani, Birgit Högl, Werner Poewe, David Kemlink, Karel Sonka, Cornelius G Bachmann, Walter Paulus, Claudia Trenkwalder, Wolfgang H Oertel, Magdolna Hornyak, Maris Teder-Laving, Andres Metspalu, Georgios M Hadjigeorgiou, Olli Polo, Ingo Fietze, Owen A Ross, Zbigniew Wszolek, Adam S Butterworth, Nicole Soranzo, Willem H Ouwehand, David J Roberts, John Danesh, Richard P Allen, Christopher J Earley, William G Ondo, Lan Xiong, Jacques Montplaisir, Ziv Gan-Or, Markus Perola, Pavel Vodicka, Christian Dina, Andre Franke, Lukas Tittmann, Alexandre F R Stewart, Svati H Shah, Christian Gieger, Annette Peters, Guy A Rouleau, Klaus Berger, Konrad Oexle, Emanuele Di Angelantonio, David A Hinds, Bertram Müller-Myhsok, Juliane Winkelmann
BACKGROUND: Restless legs syndrome is a prevalent chronic neurological disorder with potentially severe mental and physical health consequences. Clearer understanding of the underlying pathophysiology is needed to improve treatment options. We did a meta-analysis of genome-wide association studies (GWASs) to identify potential molecular targets. METHODS: In the discovery stage, we combined three GWAS datasets (EU-RLS GENE, INTERVAL, and 23andMe) with diagnosis data collected from 2003 to 2017, in face-to-face interviews or via questionnaires, and involving 15 126 cases and 95 725 controls of European ancestry...
November 2017: Lancet Neurology
https://www.readbyqxmd.com/read/29027235/low-dose-ct-for-the-detection-and-classification-of-metastatic-liver-lesions-results-of-the-2016-low-dose-ct-grand-challenge
#5
Cynthia H McCollough, Adam C Bartley, Rickey E Carter, Baiyu Chen, Tammy A Drees, Phillip Edwards, David R Holmes, Alice E Huang, Farhana Khan, Shuai Leng, Kyle L McMillan, Gregory J Michalak, Kristina M Nunez, Lifeng Yu, Joel G Fletcher
PURPOSE: Using common datasets, to estimate and compare the diagnostic performance of image-based denoising techniques or iterative reconstruction algorithms for the task of detecting hepatic metastases. METHODS: Datasets from contrast-enhanced CT scans of the liver were provided to participants in an NIH-, AAPM- and Mayo Clinic-sponsored Low Dose CT Grand Challenge. Training data included full-dose and quarter-dose scans of the ACR CT accreditation phantom and 10 patient examinations; both images and projections were provided in the training data...
October 2017: Medical Physics
https://www.readbyqxmd.com/read/29025901/effects-of-age-and-exercise-training-on-coronary-microvascular-smooth-muscle-phenotype-and-function
#6
Judy M Muller-Delp, Kazuki Hotta, Bei Chen, Bradley Jon Behnke, Joshua J Maraj, Michael D Delp, Tiffani R Lucero, Jeremy A Bramy, David B Alarcon, Hannah E Morgan, Morgan R Cowan, Anthony D Haynes
Coronary microvascular function and blood flow responses during acute exercise are impaired in the aged heart, but can be restored by exercise training. Coronary microvascular resistance is directly dependent on vascular smooth muscle function in coronary resistance arterioles; therefore, we hypothesized that age impairs contractile function and alters the phenotype of vascular smooth muscle in coronary arterioles. We further hypothesized that exercise training restores contractile function and reverses age-induced phenotypic alterations of arteriolar smooth muscle...
October 12, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29025771/endothelial-activation-and-blood-brain-barrier-disruption-in-neurotoxicity-after-adoptive-immunotherapy-with-cd19-car-t-cells
#7
Juliane Gust, Kevin A Hay, Laïla-Aïcha Hanafi, Daniel Li, David Myerson, Luis F Gonzalez-Cuyar, Cecilia Yeung, W Conrad Liles, Mark Wurfel, Jose A Lopez, Junmei Chen, Dominic Chung, Susanna Harju-Baker, Tahsin Özpolat, Kathleen R Fink, Stanley R Riddell, David G Maloney, Cameron J Turtle
Lymphodepletion chemotherapy followed by infusion of CD19-targeted chimeric antigen receptor-modified T (CAR-T) cells can be complicated by neurologic adverse events (AE) in patients with refractory B-cell malignancies. In 133 adults treated with CD19 CAR-T cells, we found that acute lymphoblastic leukemia, high CD19(+) cells in bone marrow, high CAR-T cell dose, cytokine release syndrome, and preexisting neurologic comorbidities were associated with increased risk of neurologic AEs. Patients with severe neurotoxicity demonstrated evidence of endothelial activation, including disseminated intravascular coagulation, capillary leak, and increased blood-brain barrier (BBB) permeability...
October 12, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/29025436/self-monitoring-by-environmental-services-may-not-accurately-measure-thoroughness-of-hospital-room-cleaning
#8
Lauren P Knelson, Gemila K Ramadanovic, Luke F Chen, Rebekah W Moehring, Sarah S Lewis, William A Rutala, David J Weber, Daniel J Sexton, Deverick J Anderson
No abstract text is available yet for this article.
October 13, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29021841/2017-hrs-ehra-ecas-aphrs-solaece-expert-consensus-statement-on-catheter-and-surgical-ablation-of-atrial-fibrillation-executive-summary
#9
Hugh Calkins, Gerhard Hindricks, Riccardo Cappato, Young-Hoon Kim, Eduardo B Saad, Luis Aguinaga, Joseph G Akar, Vinay Badhwar, Josep Brugada, John Camm, Peng-Sheng Chen, Shih-Ann Chen, Mina K Chung, Jens Cosedis Nielsen, Anne B Curtis, D Wyn Davies, John D Day, André d'Avila, N M S Natasja de Groot, Luigi Di Biase, Mattias Duytschaever, James R Edgerton, Kenneth A Ellenbogen, Patrick T Ellinor, Sabine Ernst, Guilherme Fenelon, Edward P Gerstenfeld, David E Haines, Michel Haissaguerre, Robert H Helm, Elaine Hylek, Warren M Jackman, Jose Jalife, Jonathan M Kalman, Josef Kautzner, Hans Kottkamp, Karl Heinz Kuck, Koichiro Kumagai, Richard Lee, Thorsten Lewalter, Bruce D Lindsay, Laurent Macle, Moussa Mansour, Francis E Marchlinski, Gregory F Michaud, Hiroshi Nakagawa, Andrea Natale, Stanley Nattel, Ken Okumura, Douglas Packer, Evgeny Pokushalov, Matthew R Reynolds, Prashanthan Sanders, Mauricio Scanavacca, Richard Schilling, Claudio Tondo, Hsuan-Ming Tsao, Atul Verma, David J Wilber, Teiichi Yamane
No abstract text is available yet for this article.
October 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/29019987/establishment-of-mouse-expanded-potential-stem-cells
#10
Jian Yang, David J Ryan, Wei Wang, Jason Cheuk-Ho Tsang, Guocheng Lan, Hideki Masaki, Xuefei Gao, Liliana Antunes, Yong Yu, Zhexin Zhu, Juexuan Wang, Aleksandra A Kolodziejczyk, Lia S Campos, Cui Wang, Fengtang Yang, Zhen Zhong, Beiyuan Fu, Melanie A Eckersley-Maslin, Michael Woods, Yosuke Tanaka, Xi Chen, Adam C Wilkinson, James Bussell, Jacqui White, Ramiro Ramirez-Solis, Wolf Reik, Berthold Göttgens, Sarah A Teichmann, Patrick P L Tam, Hiromitsu Nakauchi, Xiangang Zou, Liming Lu, Pentao Liu
Mouse embryonic stem cells derived from the epiblast contribute to the somatic lineages and the germline but are excluded from the extra-embryonic tissues that are derived from the trophectoderm and the primitive endoderm upon reintroduction to the blastocyst. Here we report that cultures of expanded potential stem cells can be established from individual eight-cell blastomeres, and by direct conversion of mouse embryonic stem cells and induced pluripotent stem cells. Remarkably, a single expanded potential stem cell can contribute both to the embryo proper and to the trophectoderm lineages in a chimaera assay...
October 11, 2017: Nature
https://www.readbyqxmd.com/read/29019615/haemodynamic-profiles-of-children-with-end-stage-heart-failure
#11
Sharon Chen, John C Dykes, Doff B McElhinney, Robert J Gajarski, Andrew Y Shin, Seth A Hollander, Melanie E Everitt, Jack F Price, Ravi R Thiagarajan, Steven J Kindel, Joseph W Rossano, Beth D Kaufman, Lindsay J May, Elizabeth Pruitt, David N Rosenthal, Christopher S Almond
Aims: To evaluate associations between haemodynamic profiles and symptoms, end-organ function and outcome in children listed for heart transplantation. Methods and results: Children <18 years listed for heart transplant between 1993 and 2013 with cardiac catheterization data [pulmonary capillary wedge pressure (PCWP), right atrial pressure (RAP), and cardiac index (CI)] in the Pediatric Heart Transplant Study database were included. Outcomes were New York Heart Association (NYHA)/Ross classification, renal and hepatic dysfunction, and death or clinical deterioration while on waitlist...
October 7, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29016841/2017%C3%A2-hrs-ehra-ecas-aphrs-solaece-expert-consensus-statement-on-catheter-and-surgical-ablation-of-atrial-fibrillation-executive-summary
#12
Hugh Calkins, Gerhard Hindricks, Riccardo Cappato, Young-Hoon Kim, Eduardo B Saad, Luis Aguinaga, Joseph G Akar, Vinay Badhwar, Josep Brugada, John Camm, Peng-Sheng Chen, Shih-Ann Chen, Mina K Chung, Jens Cosedis Nielsen, Anne B Curtis, D Wyn Davies, John D Day, André d'Avila, N M S Natasja de Groot, Luigi Di Biase, Mattias Duytschaever, James R Edgerton, Kenneth A Ellenbogen, Patrick T Ellinor, Sabine Ernst, Guilherme Fenelon, Edward P Gerstenfeld, David E Haines, Michel Haissaguerre, Robert H Helm, Elaine Hylek, Warren M Jackman, Jose Jalife, Jonathan M Kalman, Josef Kautzner, Hans Kottkamp, Karl Heinz Kuck, Koichiro Kumagai, Richard Lee, Thorsten Lewalter, Bruce D Lindsay, Laurent Macle, Moussa Mansour, Francis E Marchlinski, Gregory F Michaud, Hiroshi Nakagawa, Andrea Natale, Stanley Nattel, Ken Okumura, Douglas Packer, Evgeny Pokushalov, Matthew R Reynolds, Prashanthan Sanders, Mauricio Scanavacca, Richard Schilling, Claudio Tondo, Hsuan-Ming Tsao, Atul Verma, David J Wilber, Teiichi Yamane
No abstract text is available yet for this article.
September 15, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29016840/2017-hrs-ehra-ecas-aphrs-solaece-expert-consensus-statement-on-catheter-and-surgical-ablation-of-atrial-fibrillation
#13
Hugh Calkins, Gerhard Hindricks, Riccardo Cappato, Young-Hoon Kim, Eduardo B Saad, Luis Aguinaga, Joseph G Akar, Vinay Badhwar, Josep Brugada, John Camm, Peng-Sheng Chen, Shih-Ann Chen, Mina K Chung, Jens Cosedis Nielsen, Anne B Curtis, D Wyn Davies, John D Day, André d'Avila, N M S Natasja de Groot, Luigi Di Biase, Mattias Duytschaever, James R Edgerton, Kenneth A Ellenbogen, Patrick T Ellinor, Sabine Ernst, Guilherme Fenelon, Edward P Gerstenfeld, David E Haines, Michel Haissaguerre, Robert H Helm, Elaine Hylek, Warren M Jackman, Jose Jalife, Jonathan M Kalman, Josef Kautzner, Hans Kottkamp, Karl Heinz Kuck, Koichiro Kumagai, Richard Lee, Thorsten Lewalter, Bruce D Lindsay, Laurent Macle, Moussa Mansour, Francis E Marchlinski, Gregory F Michaud, Hiroshi Nakagawa, Andrea Natale, Stanley Nattel, Ken Okumura, Douglas Packer, Evgeny Pokushalov, Matthew R Reynolds, Prashanthan Sanders, Mauricio Scanavacca, Richard Schilling, Claudio Tondo, Hsuan-Ming Tsao, Atul Verma, David J Wilber, Teiichi Yamane
No abstract text is available yet for this article.
September 15, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28990607/the-effect-of-centred-versus-offset-interpenetration-on-c2h2-sorption-in-hybrid-ultramicroporous-materials
#14
Alankriti Bajpai, Daniel O'Nolan, David G Madden, Kai-Jie Chen, Tony Pham, Amrit Kumar, Matteo Lusi, John J Perry, Brian Space, Michael J Zaworotko
Fine-tuning of hybrid ultramicroporous materials (HUMs) can significantly impact their gas sorption performance. This study reveals that offset interpenetration can be antagonistic with respect to C2H2 separation from C2H2/C2H4 gas mixtures.
October 9, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28989963/ultrathin-thermoresponsive-self-folding-3d-graphene
#15
Weinan Xu, Zhao Qin, Chun-Teh Chen, Hye Rin Kwag, Qinli Ma, Anjishnu Sarkar, Markus J Buehler, David H Gracias
Graphene and other two-dimensional materials have unique physical and chemical properties of broad relevance. It has been suggested that the transformation of these atomically planar materials to three-dimensional (3D) geometries by bending, wrinkling, or folding could significantly alter their properties and lead to novel structures and devices with compact form factors, but strategies to enable this shape change remain limited. We report a benign thermally responsive method to fold and unfold monolayer graphene into predesigned, ordered 3D structures...
October 2017: Science Advances
https://www.readbyqxmd.com/read/28985807/age-related-macular-degeneration-is-polypoidal-choroidal-vasculopathy-recognized-and-treated
#16
Yufeng N Chen, Robert G Devenyi, Michael H Brent, Peter J Kertes, Kenneth T Eng, Carol E Schwartz, Radha P Kohly, David R Chow, David T Wong, Alan R Berger, Fil Altomare, Louis R Giavedoni, Rajeev H Muni, Alexander Soon, Patrick Yoo, Wai-Ching Lam
OBJECTIVE: To assess how polypoidal choroidal vasculopathy (PCV) is recognized and treated, and to assess whether treatment outcomes are different between Chinese and Caucasian Canadian patients with age-related macular degeneration (AMD). DESIGN: Retrospective chart review. PARTICIPANTS: 154 eyes from 135 Chinese patients and 2291 eyes from 1792 Caucasian patients who were newly diagnosed with either AMD or PCV and had more than 1 year of follow-up were included...
October 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28982112/lymph-node-metastases-in-resected-pancreatic-ductal-adenocarcinoma-predictors-of-disease-recurrence-and-survival
#17
Vicente Morales-Oyarvide, Douglas A Rubinson, Richard F Dunne, Margaret M Kozak, Justin L Bui, Chen Yuan, Zhi Rong Qian, Ana Babic, Annacarolina Da Silva, Jonathan A Nowak, Natalia Khalaf, Lauren K Brais, Marisa W Welch, Caitlin L Zellers, Kimmie Ng, Daniel T Chang, Rebecca A Miksad, Andrea J Bullock, Jennifer F Tseng, Richard S Swanson, Thomas E Clancy, David C Linehan, Jennifer J Findeis-Hosey, Leona A Doyle, Jason L Hornick, Shuji Ogino, Charles S Fuchs, Aram F Hezel, Albert C Koong, Brian M Wolpin
BACKGROUND: Few studies have simultaneously assessed the prognostic value of the multiple classification systems for lymph node (LN) metastases in resected pancreatic ductal adenocarcinoma (PDAC). METHODS: In 600 patients with resected PDAC, we examined the association of LN parameters (AJCC 7th and 8th editions, LN ratio (LNR), and log odds of metastatic LN (LODDS)) with pattern of recurrence and patient survival using logistic regression and Cox proportional hazards regression, respectively...
October 5, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28981430/detection-of-sources-in-non-negative-blind-source-separation-by-minimum-description-length-criterion
#18
Chia-Hsiang Lin, Chong-Yung Chi, Lulu Chen, David J Miller, Yue Wang
While non-negative blind source separation (nBSS) has found many successful applications in science and engineering, model order selection, determining the number of sources, remains a critical yet unresolved problem. Various model order selection methods have been proposed and applied to real-world data sets but with limited success, with both order over- and under-estimation reported. By studying existing schemes, we have found that the unsatisfactory results are mainly due to invalid assumptions, model oversimplification, subjective thresholding, and/or to assumptions made solely for mathematical convenience...
October 3, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28975666/methods-for-estimation-of-model-accuracy-in-casp12
#19
Arne Elofsson, Keehyoung Joo, Chen Keasar, Jooyoung Lee, Ali H A Maghrabi, Balachandran Manavalan, Liam J McGuffin, David Ménendez Hurtado, Claudio Mirabello, Robert Pilstål, Tomer Sidi, Karolis Uziela, Björn Wallner
Methods to reliably estimate the quality of 3D models of proteins are essential drivers for the wide adoption and serious acceptance of protein structure predictions by life scientists. In this paper, the most successful groups in CASP12 describe their latest methods for Estimates of Model Accuracy (EMA). We show that pure single model accuracy estimation methods have shown clear progress since CASP11; the three top methods (MESHI, ProQ3, SVMQA) all perform better than the top method of CASP11 (ProQ2). While the pure single model accuracy estimation methods outperform quasi-single (ModFOLD6 variations) and consensus methods (Pcons, ModFOLDclust2, Pcomb-domain and Wallner) in model selection, they are still not as good as those methods in absolute model quality estimation and predictions of local quality...
October 4, 2017: Proteins
https://www.readbyqxmd.com/read/28974547/common-tdp1-polymorphisms-in-relation-to-survival-among-small-cell-lung-cancer-patients-a-multicenter-study-from-the-international-lung-cancer-consortium
#20
Pawadee Lohavanichbutr, Lori C Sakoda, Christopher I Amos, Susanne M Arnold, David C Christiani, Michael P A Davies, John K Field, Eric B Haura, Rayjean J Hung, Takashi Kohno, Maria Teresa Landi, Geoffrey Liu, Yi Liu, Michael W Marcus, Grainne M O'Kane, Matthew B Schabath, Kouya Shiraishi, Stacey A Slone, Adonina Tardon, Ping Yang, Kazushi Yoshida, Ruyang Zhang, Xuchen Zong, Gary G Goodman, Noel S Weiss, Chu Chen
PURPOSE: DNA topoisomerase inhibitors are commonly used for treating small cell lung cancer (SCLC). Tyrosyl-DNA phosphodiesterase (TDP1) repairs DNA damage caused by this class of drugs and may therefore influence treatment outcome. In this study, we investigated whether common TDP1 single nucleotide polymorphisms (SNPs) are associated with overall survival among SCLC patients. EXPERIMENTAL DESIGN: Two TDP1 SNPs (rs942190 and rs2401863) were analyzed in 890 patients from 10 studies in the International Lung Cancer Consortium (ILCCO)...
October 3, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
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