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https://www.readbyqxmd.com/read/29907409/conversion-of-calibration-curves-for-accurate-estimation-of-molecular-weight-averages-and-distributions-of-polyether-polyols-by-conventional-size-exclusion-chromatography
#1
Xiuqing Xu, Xiuhan Yang, Steven J Martin, Edwin Mes, Junlan Chen, David M Meunier
Accurate measurement of molecular weight averages (M¯n, M¯w, M¯z ) and molecular weight distributions (MWD) of polyether polyols by conventional SEC (size exclusion chromatography) is not as straightforward as it would appear. Conventional calibration with polystyrene (PS) standards can only provide PS apparent molecular weights which do not provide accurate estimates of polyol molecular weights. Using polyethylene oxide/polyethylene glycol (PEO/PEG) for molecular weight calibration could improve the accuracy, but the retention behavior of PEO/PEG is not stable in THF-based (tetrahydrofuran) SEC systems...
April 24, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29906166/search-for-heavy-neutral-leptons-in-events-with-three-charged-leptons-in-proton-proton-collisions-at-sqrt-s-13-tev
#2
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Micheli, P Musella, F Nessi-Tedaldi, F Pandolfi, J Pata, F Pauss, G Perrin, L Perrozzi, M Quittnat, M Reichmann, D A Sanz Becerra, M Schönenberger, L Shchutska, V R Tavolaro, K Theofilatos, M L Vesterbacka Olsson, R Wallny, D H Zhu, T K Aarrestad, C Amsler, D Brzhechko, M F Canelli, A De Cosa, R Del Burgo, S Donato, C Galloni, T Hreus, B Kilminster, I Neutelings, D Pinna, G Rauco, P Robmann, D Salerno, K Schweiger, C Seitz, Y Takahashi, A Zucchetta, V Candelise, Y H Chang, K Y Cheng, T H Doan, Sh Jain, R Khurana, C M Kuo, W Lin, A Pozdnyakov, S S Yu, Arun Kumar, P Chang, Y Chao, K F Chen, P H Chen, F Fiori, W-S Hou, Y Hsiung, Y F Liu, R-S Lu, E Paganis, A Psallidas, A Steen, J F Tsai, B Asavapibhop, K Kovitanggoon, G Singh, N Srimanobhas, M N Bakirci, A Bat, F Boran, S Damarseckin, Z S Demiroglu, C Dozen, E Eskut, S Girgis, G Gokbulut, Y Guler, I Hos, E E Kangal, O Kara, U Kiminsu, M Oglakci, G Onengut, K Ozdemir, S Ozturk, A Polatoz, D Sunar Cerci, U G Tok, S Turkcapar, I S Zorbakir, C Zorbilmez, G Karapinar, K Ocalan, M Yalvac, M Zeyrek, E Gülmez, M Kaya, O Kaya, S Tekten, E A Yetkin, M N Agaras, S Atay, A Cakir, K Cankocak, Y Komurcu, B Grynyov, L Levchuk, F Ball, L Beck, J J Brooke, D Burns, E Clement, D Cussans, O Davignon, H Flacher, J Goldstein, G P Heath, H F Heath, L Kreczko, D M Newbold, S Paramesvaran, T Sakuma, S Seif El Nasr-Storey, D Smith, V J Smith, K W Bell, A Belyaev, C Brew, R M Brown, L Calligaris, D Cieri, D J A Cockerill, J A Coughlan, K Harder, S Harper, J Linacre, E Olaiya, D Petyt, C H Shepherd-Themistocleous, A Thea, I R Tomalin, T Williams, W J Womersley, G Auzinger, R Bainbridge, P Bloch, J Borg, S Breeze, O Buchmuller, A Bundock, S Casasso, D Colling, L Corpe, P Dauncey, G Davies, M Della Negra, R Di Maria, Y Haddad, G Hall, G Iles, T James, M Komm, R Lane, C Laner, L Lyons, A-M Magnan, S Malik, L Mastrolorenzo, T Matsushita, J Nash, A Nikitenko, V Palladino, M Pesaresi, A Richards, A Rose, E Scott, C Seez, A Shtipliyski, T Strebler, S Summers, A Tapper, K Uchida, M Vazquez Acosta, T Virdee, N Wardle, D Winterbottom, J Wright, S C Zenz, J E Cole, P R Hobson, A Khan, P Kyberd, A Morton, I D Reid, L Teodorescu, S Zahid, A Borzou, K Call, J Dittmann, K Hatakeyama, H Liu, N Pastika, C Smith, R Bartek, A Dominguez, A Buccilli, S I Cooper, C Henderson, P Rumerio, C West, D Arcaro, A Avetisyan, T Bose, D Gastler, D Rankin, C Richardson, J Rohlf, L Sulak, D Zou, G Benelli, D Cutts, M Hadley, J Hakala, U Heintz, J M Hogan, K H M Kwok, E Laird, G Landsberg, J Lee, Z Mao, M Narain, J Pazzini, S Piperov, S Sagir, R Syarif, D Yu, R Band, C Brainerd, R Breedon, D Burns, M Calderon De La Barca Sanchez, M Chertok, J Conway, R Conway, P T Cox, R Erbacher, C Flores, G Funk, W Ko, R Lander, C Mclean, M Mulhearn, D Pellett, J Pilot, S Shalhout, M Shi, J Smith, D Stolp, D Taylor, K Tos, M Tripathi, Z Wang, F Zhang, M Bachtis, C Bravo, R Cousins, A Dasgupta, A Florent, J Hauser, M Ignatenko, N Mccoll, S Regnard, D Saltzberg, C Schnaible, V Valuev, E Bouvier, K Burt, R Clare, J Ellison, J W Gary, S M A Ghiasi Shirazi, G Hanson, G Karapostoli, E Kennedy, F Lacroix, O R Long, M Olmedo Negrete, M I Paneva, W Si, L Wang, H Wei, S Wimpenny, B R Yates, J G Branson, S Cittolin, M Derdzinski, R Gerosa, D Gilbert, B Hashemi, A Holzner, D Klein, G Kole, V Krutelyov, J Letts, M Masciovecchio, D Olivito, S Padhi, M Pieri, M Sani, V Sharma, S Simon, M Tadel, A Vartak, S Wasserbaech, J Wood, F Würthwein, A Yagil, G Zevi Della Porta, N Amin, R Bhandari, J Bradmiller-Feld, C Campagnari, M Citron, A Dishaw, V Dutta, M Franco Sevilla, L Gouskos, R Heller, J Incandela, A Ovcharova, H Qu, J Richman, D Stuart, I Suarez, J Yoo, D Anderson, A Bornheim, J Bunn, J M Lawhorn, H B Newman, T Q Nguyen, C Pena, M Spiropulu, J R Vlimant, R Wilkinson, S Xie, Z Zhang, R Y Zhu, M B Andrews, T Ferguson, T Mudholkar, M Paulini, J Russ, M Sun, H Vogel, I Vorobiev, M Weinberg, J P Cumalat, W T Ford, F Jensen, A Johnson, M Krohn, S Leontsinis, E Macdonald, T Mulholland, K Stenson, K A Ulmer, S R Wagner, J Alexander, J Chaves, Y Cheng, J Chu, A Datta, S Dittmer, K Mcdermott, N Mirman, J R Patterson, D Quach, A Rinkevicius, A Ryd, L Skinnari, L Soffi, S M Tan, Z Tao, J Thom, J Tucker, P Wittich, M Zientek, S Abdullin, M Albrow, M Alyari, G Apollinari, A Apresyan, A Apyan, S Banerjee, L A T Bauerdick, A Beretvas, J Berryhill, P C Bhat, G Bolla, K Burkett, J N Butler, A Canepa, G B Cerati, H W K Cheung, F Chlebana, M Cremonesi, J Duarte, V D Elvira, J Freeman, Z Gecse, E Gottschalk, L Gray, D Green, S Grünendahl, O Gutsche, J Hanlon, R M Harris, S Hasegawa, J Hirschauer, Z Hu, B Jayatilaka, S Jindariani, M Johnson, U Joshi, B Klima, B Kreis, S Lammel, D Lincoln, R Lipton, M Liu, T Liu, R Lopes De Sá, J Lykken, K Maeshima, N Magini, J M Marraffino, D Mason, P McBride, P Merkel, S Mrenna, S Nahn, V O'Dell, K Pedro, O Prokofyev, G Rakness, L Ristori, A Savoy-Navarro, B Schneider, E Sexton-Kennedy, A Soha, W J Spalding, L Spiegel, S Stoynev, J Strait, N Strobbe, L Taylor, S Tkaczyk, N V Tran, L Uplegger, E W Vaandering, C Vernieri, M Verzocchi, R Vidal, M Wang, H A Weber, A Whitbeck, W Wu, D Acosta, P Avery, P Bortignon, D Bourilkov, A Brinkerhoff, A Carnes, M Carver, D Curry, R D Field, I K Furic, S V Gleyzer, B M Joshi, J Konigsberg, A Korytov, K Kotov, P Ma, K Matchev, H Mei, G Mitselmakher, K Shi, D Sperka, N Terentyev, L Thomas, J Wang, S Wang, J Yelton, Y R Joshi, S Linn, P Markowitz, J L Rodriguez, A Ackert, T Adams, A Askew, S Hagopian, V Hagopian, K F Johnson, T Kolberg, G Martinez, T Perry, H Prosper, A Saha, A Santra, V Sharma, R Yohay, M M Baarmand, V Bhopatkar, S Colafranceschi, M Hohlmann, D Noonan, T Roy, F Yumiceva, M R Adams, L Apanasevich, D Berry, R R Betts, R Cavanaugh, X Chen, O Evdokimov, C E Gerber, D A Hangal, D J Hofman, K Jung, J Kamin, I D Sandoval Gonzalez, M B Tonjes, N Varelas, H Wang, Z Wu, J Zhang, B Bilki, W Clarida, K Dilsiz, S Durgut, R P Gandrajula, M Haytmyradov, V Khristenko, J-P Merlo, H Mermerkaya, A Mestvirishvili, A Moeller, J Nachtman, H Ogul, Y Onel, F Ozok, A Penzo, C Snyder, E Tiras, J Wetzel, K Yi, B Blumenfeld, A Cocoros, N Eminizer, D Fehling, L Feng, A V Gritsan, P Maksimovic, J Roskes, U Sarica, M Swartz, M Xiao, C You, A Al-Bataineh, P Baringer, A Bean, S Boren, J Bowen, J Castle, S Khalil, A Kropivnitskaya, D Majumder, W Mcbrayer, M Murray, C Rogan, C Royon, S Sanders, E Schmitz, J D Tapia Takaki, Q Wang, A Ivanov, K Kaadze, Y Maravin, A Mohammadi, L K Saini, N Skhirtladze, F Rebassoo, D Wright, A Baden, O Baron, A Belloni, S C Eno, Y Feng, C Ferraioli, N J Hadley, S Jabeen, G Y Jeng, R G Kellogg, J Kunkle, A C Mignerey, F Ricci-Tam, Y H Shin, A Skuja, S C Tonwar, D Abercrombie, B Allen, V Azzolini, R Barbieri, A Baty, G Bauer, R Bi, S Brandt, W Busza, I A Cali, M D'Alfonso, Z Demiragli, G Gomez Ceballos, M Goncharov, P Harris, D Hsu, M Hu, Y Iiyama, G M Innocenti, M Klute, D Kovalskyi, Y-J Lee, A Levin, P D Luckey, B Maier, A C Marini, C Mcginn, C Mironov, S Narayanan, X Niu, C Paus, C Roland, G Roland, J Salfeld-Nebgen, G S F Stephans, K Sumorok, K Tatar, D Velicanu, J Wang, T W Wang, B Wyslouch, S Zhaozhong, A C Benvenuti, R M Chatterjee, A Evans, P Hansen, S Kalafut, Y Kubota, Z Lesko, J Mans, S Nourbakhsh, N Ruckstuhl, R Rusack, J Turkewitz, M A Wadud, J G Acosta, S Oliveros, E Avdeeva, K Bloom, D R Claes, C Fangmeier, F Golf, R Gonzalez Suarez, R Kamalieddin, I Kravchenko, J Monroy, J E Siado, G R Snow, B Stieger, J Dolen, A Godshalk, C Harrington, I Iashvili, D Nguyen, A Parker, S Rappoccio, B Roozbahani, G Alverson, E Barberis, C Freer, A Hortiangtham, A Massironi, D M Morse, T Orimoto, R Teixeira De Lima, T Wamorkar, B Wang, A Wisecarver, D Wood, S Bhattacharya, O Charaf, K A Hahn, N Mucia, N Odell, M H Schmitt, K Sung, M Trovato, M Velasco, R Bucci, N Dev, M Hildreth, K Hurtado Anampa, C Jessop, D J Karmgard, N Kellams, K Lannon, W Li, N Loukas, N Marinelli, F Meng, C Mueller, Y Musienko, M Planer, A Reinsvold, R Ruchti, P Siddireddy, G Smith, S Taroni, M Wayne, A Wightman, M Wolf, A Woodard, J Alimena, L Antonelli, B Bylsma, L S Durkin, S Flowers, B Francis, A Hart, C Hill, W Ji, T Y Ling, W Luo, B L Winer, H W Wulsin, S Cooperstein, O Driga, P Elmer, J Hardenbrook, P Hebda, S Higginbotham, A Kalogeropoulos, D Lange, J Luo, D Marlow, K Mei, I Ojalvo, J Olsen, C Palmer, P Piroué, D Stickland, C Tully, S Malik, S Norberg, A Barker, V E Barnes, S Das, L Gutay, M Jones, A W Jung, A Khatiwada, D H Miller, N Neumeister, C C Peng, H Qiu, J F Schulte, J Sun, F Wang, R Xiao, W Xie, T Cheng, N Parashar, Z Chen, K M Ecklund, S Freed, F J M Geurts, M Guilbaud, M Kilpatrick, W Li, B Michlin, B P Padley, J Roberts, J Rorie, W Shi, Z Tu, J Zabel, A Zhang, A Bodek, P de Barbaro, R Demina, Y T Duh, T Ferbel, M Galanti, A Garcia-Bellido, J Han, O Hindrichs, A Khukhunaishvili, K H Lo, P Tan, M Verzetti, R Ciesielski, K Goulianos, C Mesropian, A Agapitos, J P Chou, Y Gershtein, T A Gómez Espinosa, E Halkiadakis, M Heindl, E Hughes, S Kaplan, R Kunnawalkam Elayavalli, S Kyriacou, A Lath, R Montalvo, K Nash, M Osherson, H Saka, S Salur, S Schnetzer, D Sheffield, S Somalwar, R Stone, S Thomas, P Thomassen, M Walker, A G Delannoy, J Heideman, G Riley, K Rose, S Spanier, K Thapa, O Bouhali, A Castaneda Hernandez, A Celik, M Dalchenko, M De Mattia, A Delgado, S Dildick, R Eusebi, J Gilmore, T Huang, T Kamon, R Mueller, Y Pakhotin, R Patel, A Perloff, L Perniè, D Rathjens, A Safonov, A Tatarinov, N Akchurin, J Damgov, F De Guio, P R Dudero, J Faulkner, E Gurpinar, S Kunori, K Lamichhane, S W Lee, T Mengke, S Muthumuni, T Peltola, S Undleeb, I Volobouev, Z Wang, S Greene, A Gurrola, R Janjam, W Johns, C Maguire, A Melo, H Ni, K Padeken, P Sheldon, S Tuo, J Velkovska, Q Xu, M W Arenton, P Barria, B Cox, R Hirosky, M Joyce, A Ledovskoy, H Li, C Neu, T Sinthuprasith, Y Wang, E Wolfe, F Xia, R Harr, P E Karchin, N Poudyal, J Sturdy, P Thapa, S Zaleski, M Brodski, J Buchanan, C Caillol, D Carlsmith, S Dasu, L Dodd, S Duric, B Gomber, M Grothe, M Herndon, A Hervé, U Hussain, P Klabbers, A Lanaro, A Levine, K Long, R Loveless, V Rekovic, T Ruggles, A Savin, N Smith, W H Smith, N Woods
A search for a heavy neutral lepton N of Majorana nature decaying into a W boson and a charged lepton is performed using the CMS detector at the LHC. The targeted signature consists of three prompt charged leptons in any flavor combination of electrons and muons. The data were collected in proton-proton collisions at a center-of-mass energy of 13 TeV, with an integrated luminosity of 35.9  fb^{-1}. The search is performed in the N mass range between 1 GeV and 1.2 TeV. The data are found to be consistent with the expected standard model background...
June 1, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29905973/effects-of-teriparatide-and-vibration-on-bone-mass-and-bone-strength-in-people-with-bone-loss-and-spinal-cord-injury-a-randomized-controlled-trial
#3
W Brent Edwards, Narina Simonian, Ifaz T Haider, Alan S Anschel, David Chen, Keith E Gordon, Elaine K Gregory, Ki H Kim, Ramadevi Parachuri, Karen L Troy, Thomas J Schnitzer
Spinal cord injury (SCI) is associated with marked bone loss and an increased risk of fracture. We randomized 61 individuals with chronic SCI and low bone mass to receive either: teriparatide 20 µg/day plus sham vibration 10 min/day (n = 20), placebo plus vibration 10 min/day (n = 20), or teriparatide 20 µg/day plus vibration 10 min/day (n = 21). Patients were evaluated for 12 months; those who completed were given the opportunity to participate in an open-label extension where all participants (n = 25) received teriparatide 20 µg/day for an additional 12 months and had the optional use of vibration (10 min/day)...
June 15, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29905649/multivariate-pattern-classification-of-brain-white-matter-connectivity-predicts-classic-trigeminal-neuralgia
#4
Jidan Zhong, David Qixiang Chen, Peter S P Hung, Dave J Hayes, Kevin E Liang, Karen D Davis, Mojgan Hodaie
Trigeminal neuralgia (TN) is a severe form of chronic facial neuropathic pain. Increasing interest in the neuroimaging of pain has highlighted changes in the root entry zone in TN, but also group level CNS grey and white matter abnormalities. Group differences in neuroimaging data are frequently evaluated with univariate statistics, however this approach is limited because it is based on single, or clusters of, voxels. In contrast, multivariate pattern analyses consider all the model's neuroanatomical features to capture a specific distributed spatial pattern...
June 13, 2018: Pain
https://www.readbyqxmd.com/read/29904359/analysis-of-the-influence-of-micrornas-in-lithium-response-in-bipolar-disorder
#5
Céline S Reinbold, Andreas J Forstner, Julian Hecker, Janice M Fullerton, Per Hoffmann, Liping Hou, Urs Heilbronner, Franziska Degenhardt, Mazda Adli, Kazufumi Akiyama, Nirmala Akula, Raffaella Ardau, Bárbara Arias, Lena Backlund, Antonio Benabarre, Susanne Bengesser, Abesh K Bhattacharjee, Joanna M Biernacka, Armin Birner, Cynthia Marie-Claire, Pablo Cervantes, Guo-Bo Chen, Hsi-Chung Chen, Caterina Chillotti, Scott R Clark, Francesc Colom, David A Cousins, Cristiana Cruceanu, Piotr M Czerski, Alexandre Dayer, Bruno Étain, Peter Falkai, Louise Frisén, Sébastien Gard, Julie S Garnham, Fernando S Goes, Paul Grof, Oliver Gruber, Ryota Hashimoto, Joanna Hauser, Stefan Herms, Stéphane Jamain, Esther Jiménez, Jean-Pierre Kahn, Layla Kassem, Sarah Kittel-Schneider, Sebastian Kliwicki, Barbara König, Ichiro Kusumi, Nina Lackner, Gonzalo Laje, Mikael Landén, Catharina Lavebratt, Marion Leboyer, Susan G Leckband, Carlos A López Jaramillo, Glenda MacQueen, Mirko Manchia, Lina Martinsson, Manuel Mattheisen, Michael J McCarthy, Susan L McElroy, Marina Mitjans, Francis M Mondimore, Palmiero Monteleone, Caroline M Nievergelt, Urban Ösby, Norio Ozaki, Roy H Perlis, Andrea Pfennig, Daniela Reich-Erkelenz, Guy A Rouleau, Peter R Schofield, K Oliver Schubert, Barbara W Schweizer, Florian Seemüller, Giovanni Severino, Tatyana Shekhtman, Paul D Shilling, Kazutaka Shimoda, Christian Simhandl, Claire M Slaney, Jordan W Smoller, Alessio Squassina, Thomas J Stamm, Pavla Stopkova, Sarah K Tighe, Alfonso Tortorella, Gustavo Turecki, Julia Volkert, Stephanie H Witt, Adam J Wright, L Trevor Young, Peter P Zandi, James B Potash, J Raymond DePaulo, Michael Bauer, Eva Reininghaus, Tomáš Novák, Jean-Michel Aubry, Mario Maj, Bernhard T Baune, Philip B Mitchell, Eduard Vieta, Mark A Frye, Janusz K Rybakowski, Po-Hsiu Kuo, Tadafumi Kato, Maria Grigoroiu-Serbanescu, Andreas Reif, Maria Del Zompo, Frank Bellivier, Martin Schalling, Naomi R Wray, John R Kelsoe, Martin Alda, Francis J McMahon, Thomas G Schulze, Marcella Rietschel, Markus M Nöthen, Sven Cichon
Bipolar disorder (BD) is a common, highly heritable neuropsychiatric disease characterized by recurrent episodes of mania and depression. Lithium is the best-established long-term treatment for BD, even though individual response is highly variable. Evidence suggests that some of this variability has a genetic basis. This is supported by the largest genome-wide association study (GWAS) of lithium response to date conducted by the International Consortium on Lithium Genetics (ConLiGen). Recently, we performed the first genome-wide analysis of the involvement of miRNAs in BD and identified nine BD-associated miRNAs...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29902625/the-effect-of-fe-2-nio-4-and-fe-4-nio-4-zn-magnetic-nanoparticles-on-anaerobic-digestion-activity
#6
Jian Lin Chen, Terry W J Steele, David C Stuckey
Two types of magnetic nanoparticles (MNPs), i.e. Ni ferrite nanoparticles (Fe2 NiO4 ) and Ni Zn ferrite nanoparticles (Fe4 NiO4 Zn) containing the trace metals Ni and Fe, were added to the anaerobic digestion of synthetic municipal wastewater at concentrations between 1 and 100 mg Ni L-1 in order to compare their effects on biogas (methane) production and sludge activity. Using the production of methane over time as a measure, the assays revealed that anaerobic digestion was stimulated by the addition of 100 mg Ni L-1 in Fe2 NiO4 NPs, while it was inhibited by the addition of 1-100 mg Ni L-1 in Fe4 NiO4 Zn NPs...
June 11, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29899525/genome-wide-association-study-of-habitual-physical-activity-in-over-377-000-uk-biobank-participants-identifies-multiple-variants-including-cadm2-and-apoe
#7
Yann C Klimentidis, David A Raichlen, Jennifer Bea, David O Garcia, Nathan E Wineinger, Lawrence J Mandarino, Gene E Alexander, Zhao Chen, Scott B Going
BACKGROUND/OBJECTIVES: Physical activity (PA) protects against a wide range of diseases. Habitual PA appears to be heritable, motivating the search for specific genetic variants that may inform efforts to promote PA and target the best type of PA for each individual. SUBJECTS/METHODS: We used data from the UK Biobank to perform the largest genome-wide association study of PA to date, using three measures based on self-report (nmax  = 377,234) and two measures based on wrist-worn accelerometry data (nmax  = 91,084)...
June 13, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29899519/genetic-inactivation-of-angptl4-improves-glucose-homeostasis-and-is-associated-with-reduced-risk-of-diabetes
#8
Viktoria Gusarova, Colm O'Dushlaine, Tanya M Teslovich, Peter N Benotti, Tooraj Mirshahi, Omri Gottesman, Cristopher V Van Hout, Michael F Murray, Anubha Mahajan, Jonas B Nielsen, Lars Fritsche, Anders Berg Wulff, Daniel F Gudbjartsson, Marketa Sjögren, Connor A Emdin, Robert A Scott, Wen-Jane Lee, Aeron Small, Lydia C Kwee, Om Prakash Dwivedi, Rashmi B Prasad, Shannon Bruse, Alexander E Lopez, John Penn, Anthony Marcketta, Joseph B Leader, Christopher D Still, H Lester Kirchner, Uyenlinh L Mirshahi, Amr H Wardeh, Cassandra M Hartle, Lukas Habegger, Samantha N Fetterolf, Teresa Tusie-Luna, Andrew P Morris, Hilma Holm, Valgerdur Steinthorsdottir, Patrick Sulem, Unnur Thorsteinsdottir, Jerome I Rotter, Lee-Ming Chuang, Scott Damrauer, David Birtwell, Chad M Brummett, Amit V Khera, Pradeep Natarajan, Marju Orho-Melander, Jason Flannick, Luca A Lotta, Cristen J Willer, Oddgeir L Holmen, Marylyn D Ritchie, David H Ledbetter, Andrew J Murphy, Ingrid B Borecki, Jeffrey G Reid, John D Overton, Ola Hansson, Leif Groop, Svati H Shah, William E Kraus, Daniel J Rader, Yii-Der I Chen, Kristian Hveem, Nicholas J Wareham, Sekar Kathiresan, Olle Melander, Kari Stefansson, Børge G Nordestgaard, Anne Tybjærg-Hansen, Goncalo R Abecasis, David Altshuler, Jose C Florez, Michael Boehnke, Mark I McCarthy, George D Yancopoulos, David J Carey, Alan R Shuldiner, Aris Baras, Frederick E Dewey, Jesper Gromada
Angiopoietin-like 4 (ANGPTL4) is an endogenous inhibitor of lipoprotein lipase that modulates lipid levels, coronary atherosclerosis risk, and nutrient partitioning. We hypothesize that loss of ANGPTL4 function might improve glucose homeostasis and decrease risk of type 2 diabetes (T2D). We investigate protein-altering variants in ANGPTL4 among 58,124 participants in the DiscovEHR human genetics study, with follow-up studies in 82,766 T2D cases and 498,761 controls. Carriers of p.E40K, a variant that abolishes ANGPTL4 ability to inhibit lipoprotein lipase, have lower odds of T2D (odds ratio 0...
June 13, 2018: Nature Communications
https://www.readbyqxmd.com/read/29896547/early-aseptic-loosening-of-the-tritanium-primary-acetabular-component-with-screw-fixation
#9
William J Long, Samir Nayyar, Kevin K Chen, David Novikov, Roy I Davidovitch, Jonathan M Vigdorchik
Ultraporous acetabular components were developed to improve osseointegration and fit for increased longevity and better outcomes after total hip arthroplasty. There is a paucity of literature detailing this acetabular component's clinical performance, with even less detailing those with screw fixation. We identify 5 patients at our institution who underwent revision total hip arthroplasty for early aseptic acetabular cup loosening of an ultraporous acetabular component known as the Tritanium primary cup with secondary screw fixation...
June 2018: Arthroplasty Today
https://www.readbyqxmd.com/read/29892367/evidence-that-metallic-proxies-are-unsuitable-for-assessing-the-mechanics-of-microwear-formation-and-a-new-theory-of-the-meaning-of-microwear
#10
Adam van Casteren, Peter W Lucas, David S Strait, Shaji Michael, Nick Bierwisch, Norbert Schwarzer, Khaled J Al-Fadhalah, Abdulwahab S Almusallam, Lidia A Thai, Sreeja Saji, Ali Shekeban, Michael V Swain
Mammalian tooth wear research reveals contrasting patterns seemingly linked to diet: irregularly pitted enamel surfaces, possibly from consuming hard seeds, versus roughly aligned linearly grooved surfaces, associated with eating tough leaves. These patterns are important for assigning diet to fossils, including hominins. However, experiments establishing conditions necessary for such damage challenge this paradigm. Lucas et al . (Lucas et al . 2013 J. R. Soc. Interface 10 , 20120923. (doi:10.1098/rsif.2012...
May 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29892015/multi-ethnic-genome-wide-association-study-for-atrial-fibrillation
#11
Carolina Roselli, Mark D Chaffin, Lu-Chen Weng, Stefanie Aeschbacher, Gustav Ahlberg, Christine M Albert, Peter Almgren, Alvaro Alonso, Christopher D Anderson, Krishna G Aragam, Dan E Arking, John Barnard, Traci M Bartz, Emelia J Benjamin, Nathan A Bihlmeyer, Joshua C Bis, Heather L Bloom, Eric Boerwinkle, Erwin B Bottinger, Jennifer A Brody, Hugh Calkins, Archie Campbell, Thomas P Cappola, John Carlquist, Daniel I Chasman, Lin Y Chen, Yii-Der Ida Chen, Eue-Keun Choi, Seung Hoan Choi, Ingrid E Christophersen, Mina K Chung, John W Cole, David Conen, James Cook, Harry J Crijns, Michael J Cutler, Scott M Damrauer, Brian R Daniels, Dawood Darbar, Graciela Delgado, Joshua C Denny, Martin Dichgans, Marcus Dörr, Elton A Dudink, Samuel C Dudley, Nada Esa, Tonu Esko, Markku Eskola, Diane Fatkin, Stephan B Felix, Ian Ford, Oscar H Franco, Bastiaan Geelhoed, Raji P Grewal, Vilmundur Gudnason, Xiuqing Guo, Namrata Gupta, Stefan Gustafsson, Rebecca Gutmann, Anders Hamsten, Tamara B Harris, Caroline Hayward, Susan R Heckbert, Jussi Hernesniemi, Lynne J Hocking, Albert Hofman, Andrea R V R Horimoto, Jie Huang, Paul L Huang, Jennifer Huffman, Erik Ingelsson, Esra Gucuk Ipek, Kaoru Ito, Jordi Jimenez-Conde, Renee Johnson, J Wouter Jukema, Stefan Kääb, Mika Kähönen, Yoichiro Kamatani, John P Kane, Adnan Kastrati, Sekar Kathiresan, Petra Katschnig-Winter, Maryam Kavousi, Thorsten Kessler, Bas L Kietselaer, Paulus Kirchhof, Marcus E Kleber, Stacey Knight, Jose E Krieger, Michiaki Kubo, Lenore J Launer, Jari Laurikka, Terho Lehtimäki, Kirsten Leineweber, Rozenn N Lemaitre, Man Li, Hong Euy Lim, Henry J Lin, Honghuang Lin, Lars Lind, Cecilia M Lindgren, Marja-Liisa Lokki, Barry London, Ruth J F Loos, Siew-Kee Low, Yingchang Lu, Leo-Pekka Lyytikäinen, Peter W Macfarlane, Patrik K Magnusson, Anubha Mahajan, Rainer Malik, Alfredo J Mansur, Gregory M Marcus, Lauren Margolin, Kenneth B Margulies, Winfried März, David D McManus, Olle Melander, Sanghamitra Mohanty, Jay A Montgomery, Michael P Morley, Andrew P Morris, Martina Müller-Nurasyid, Andrea Natale, Saman Nazarian, Benjamin Neumann, Christopher Newton-Cheh, Maartje N Niemeijer, Kjell Nikus, Peter Nilsson, Raymond Noordam, Heidi Oellers, Morten S Olesen, Marju Orho-Melander, Sandosh Padmanabhan, Hui-Nam Pak, Guillaume Paré, Nancy L Pedersen, Joanna Pera, Alexandre Pereira, David Porteous, Bruce M Psaty, Sara L Pulit, Clive R Pullinger, Daniel J Rader, Lena Refsgaard, Marta Ribasés, Paul M Ridker, Michiel Rienstra, Lorenz Risch, Dan M Roden, Jonathan Rosand, Michael A Rosenberg, Natalia Rost, Jerome I Rotter, Samir Saba, Roopinder K Sandhu, Renate B Schnabel, Katharina Schramm, Heribert Schunkert, Claudia Schurman, Stuart A Scott, Ilkka Seppälä, Christian Shaffer, Svati Shah, Alaa A Shalaby, Jaemin Shim, M Benjamin Shoemaker, Joylene E Siland, Juha Sinisalo, Moritz F Sinner, Agnieszka Slowik, Albert V Smith, Blair H Smith, J Gustav Smith, Jonathan D Smith, Nicholas L Smith, Elsayed Z Soliman, Nona Sotoodehnia, Bruno H Stricker, Albert Sun, Han Sun, Jesper H Svendsen, Toshihiro Tanaka, Kahraman Tanriverdi, Kent D Taylor, Maris Teder-Laving, Alexander Teumer, Sébastien Thériault, Stella Trompet, Nathan R Tucker, Arnljot Tveit, Andre G Uitterlinden, Pim Van Der Harst, Isabelle C Van Gelder, David R Van Wagoner, Niek Verweij, Efthymia Vlachopoulou, Uwe Völker, Biqi Wang, Peter E Weeke, Bob Weijs, Raul Weiss, Stefan Weiss, Quinn S Wells, Kerri L Wiggins, Jorge A Wong, Daniel Woo, Bradford B Worrall, Pil-Sung Yang, Jie Yao, Zachary T Yoneda, Tanja Zeller, Lingyao Zeng, Steven A Lubitz, Kathryn L Lunetta, Patrick T Ellinor
Atrial fibrillation (AF) affects more than 33 million individuals worldwide 1 and has a complex heritability 2 . We conducted the largest meta-analysis of genome-wide association studies (GWAS) for AF to date, consisting of more than half a million individuals, including 65,446 with AF. In total, we identified 97 loci significantly associated with AF, including 67 that were novel in a combined-ancestry analysis, and 3 that were novel in a European-specific analysis. We sought to identify AF-associated genes at the GWAS loci by performing RNA-sequencing and expression quantitative trait locus analyses in 101 left atrial samples, the most relevant tissue for AF...
June 11, 2018: Nature Genetics
https://www.readbyqxmd.com/read/29888041/evaluating-generalizability-of-a-biospecimen-informatics-approach-support-for-local-requirements-and-best-practices
#12
Cindy Chen, Regina T Wulff, Evan T Sholle, Gail J Roboz, David A Kraemer, Thomas R Campion
To enable clinical and translational research, academic medical centers increasingly implement biospecimen information management systems. At our institution, one laboratory successfully implemented a multi-system solution that enabled collection and reporting of specimen- and aliquot-level data. The objective of this study was to assess the solution against the laboratory's requirements and with respect to support of best practices for biospecimen information management systems defined by the International Society for Biological and Environmental Repositories (ISBER)...
2018: AMIA Summits on Translational Science Proceedings
https://www.readbyqxmd.com/read/29887161/lrp10-genetic-variants-in-familial-parkinson-s-disease-and-dementia-with-lewy-bodies-a-genome-wide-linkage-and-sequencing-study
#13
Marialuisa Quadri, Wim Mandemakers, Martyna M Grochowska, Roy Masius, Hanneke Geut, Edito Fabrizio, Guido J Breedveld, Demy Kuipers, Michelle Minneboo, Leonie J M Vergouw, Ana Carreras Mascaro, Ekaterina Yonova-Doing, Erik Simons, Tianna Zhao, Alessio B Di Fonzo, Hsiu-Chen Chang, Piero Parchi, Marta Melis, Leonor Correia Guedes, Chiara Criscuolo, Astrid Thomas, Rutger W W Brouwer, Daphne Heijsman, Angela M T Ingrassia, Giovanna Calandra Buonaura, Janneke P Rood, Sabina Capellari, Annemieke J Rozemuller, Marianna Sarchioto, Hsin Fen Chien, Nicola Vanacore, Simone Olgiati, Yah-Huei Wu-Chou, Tu-Hsueh Yeh, Agnita J W Boon, Susanne E Hoogers, Mehrnaz Ghazvini, Arne S IJpma, Wilfred F J van IJcken, Marco Onofrj, Paolo Barone, David J Nicholl, Andreas Puschmann, Michele De Mari, Anneke J Kievit, Egberto Barbosa, Giuseppe De Michele, Danielle Majoor-Krakauer, John C van Swieten, Frank J de Jong, Joaquim J Ferreira, Giovanni Cossu, Chin-Song Lu, Giuseppe Meco, Pietro Cortelli, Wilma D J van de Berg, Vincenzo Bonifati
BACKGROUND: Most patients with Parkinson's disease, Parkinson's disease dementia, and dementia with Lewy bodies do not carry mutations in known disease-causing genes. The aim of this study was to identify a novel gene implicated in the development of these disorders. METHODS: Our study was done in three stages. First, we did genome-wide linkage analysis of an Italian family with dominantly inherited Parkinson's disease to identify the disease locus. Second, we sequenced the candidate gene in an international multicentre series of unrelated probands who were diagnosed either clinically or pathologically with Parkinson's disease, Parkinson's disease dementia, or dementia with Lewy bodies...
June 6, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/29886732/design-and-synthesis-of-novel-and-selective-glycine-transporter-1-glyt1-inhibitors-with-memory-enhancing-properties
#14
Vincent J Santora, Theresa A Almos, Richard Barido, Jillian Basinger, Chris L Bellows, Brett Carder Bookser, J Guy Breitenbucher, Nicola J Broadbent, Clifford Cabebe, Chih-Kun Chai, Mi Chen, Stephine Chow, De Michael Chung, Lindsay Crickard, Anne M Danks, Graeme Freestone, Dany Gitnick, Varsha Gupta, Christine Hoffmaster, Andrew R Hudson, Alan P Kaplan, Michael R Kennedy, Dong Lee, James Limberis, Kiev Ly, Chi Ching Mak, Brittany Masatsugu, Andrew C Morse, Jim Na, David Neul, John Nikpur, Marco Peters, Robert E Petroski, Joel Renick, Kristen Sebring, Samantha Sevidal, Ali Tabatabaei, Jenny Wen, Yingzhuo Yan, Zachary W Yoder, Douglas Zook
We report here the identification and optimization of a novel series of potent GlyT1 inhibitors. A ligand design campaign that utilized known GlyT1 inhibitors as starting points led to the identification of a novel series of pyrrolo[3,4-c]pyrazoles amides (21-50) with good in vitro potency. Subsequent optimization of physicochemical and in vitro ADME properties produced several compounds with promising pharmacokinetic profiles. In vivo inhibition of GlyT1 was demonstrated for select compounds within this series by measuring the elevation of glycine in the cerebrospinal fluid (CSF) of rats after a single oral dosing of 10 mg/kg...
June 11, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29884878/ultrafast-perturbation-maps-as-a-quantitative-tool-for-testing-of-multi-port-photonic-devices
#15
Kevin Vynck, Nicholas J Dinsdale, Bigeng Chen, Roman Bruck, Ali Z Khokhar, Scott A Reynolds, Lee Crudgington, David J Thomson, Graham T Reed, Philippe Lalanne, Otto L Muskens
Advanced photonic probing techniques are of great importance for the development of non-contact wafer-scale testing of photonic chips. Ultrafast photomodulation has been identified as a powerful new tool capable of remotely mapping photonic devices through a scanning perturbation. Here, we develop photomodulation maps into a quantitative technique through a general and rigorous method based on Lorentz reciprocity that allows the prediction of transmittance perturbation maps for arbitrary linear photonic systems with great accuracy and minimal computational cost...
June 8, 2018: Nature Communications
https://www.readbyqxmd.com/read/29884781/crispr-frt-targets-shared-sites-in-a-knock-out-collection-for-off-the-shelf-genome-editing
#16
Toon Swings, David C Marciano, Benu Atri, Rachel E Bosserman, Chen Wang, Marlies Leysen, Camille Bonte, Thomas Schalck, Ian Furey, Bram Van den Bergh, Natalie Verstraeten, Peter J Christie, Christophe Herman, Olivier Lichtarge, Jan Michiels
CRISPR advances genome engineering by directing endonuclease sequence specificity with a guide RNA molecule (gRNA). For precisely targeting a gene for modification, each genetic construct requires a unique gRNA. By generating a gRNA against the flippase recognition target (FRT) site, a common genetic element shared by multiple genetic collections, CRISPR-FRT circumvents this design constraint to provide a broad platform for fast, scarless, off-the-shelf genome engineering.
June 8, 2018: Nature Communications
https://www.readbyqxmd.com/read/29883151/search-for-the-decay-of-the-higgs-boson-to-charm-quarks-with-the-atlas-experiment
#17
M Aaboud, G Aad, B Abbott, O Abdinov, B Abeloos, S H Abidi, O S AbouZeid, N L Abraham, H Abramowicz, H Abreu, Y Abulaiti, B S Acharya, S Adachi, L Adamczyk, J Adelman, M Adersberger, T Adye, A A Affolder, Y Afik, C Agheorghiesei, J A Aguilar-Saavedra, S P Ahlen, F Ahmadov, G Aielli, S Akatsuka, T P A Åkesson, E Akilli, A V Akimov, G L Alberghi, J Albert, P Albicocco, M J Alconada Verzini, S Alderweireldt, M Aleksa, I N Aleksandrov, C Alexa, G Alexander, T Alexopoulos, M Alhroob, B Ali, M Aliev, G Alimonti, J Alison, S P Alkire, C Allaire, B M M Allbrooke, B W Allen, P P Allport, A Aloisio, A Alonso, F Alonso, C Alpigiani, A A Alshehri, M I Alstaty, B Alvarez Gonzalez, D Álvarez Piqueras, M G Alviggi, B T Amadio, Y Amaral Coutinho, L Ambroz, C Amelung, D Amidei, S P Amor Dos Santos, S Amoroso, C Anastopoulos, L S Ancu, N Andari, T Andeen, C F Anders, J K Anders, K J Anderson, A Andreazza, V Andrei, S Angelidakis, I Angelozzi, A Angerami, A V Anisenkov, A Annovi, C Antel, M Antonelli, A Antonov, D J Antrim, F Anulli, M Aoki, L Aperio Bella, G Arabidze, Y Arai, J P Araque, V Araujo Ferraz, R Araujo Pereira, A T H Arce, R E Ardell, F A Arduh, J-F Arguin, S Argyropoulos, A J Armbruster, L J Armitage, O Arnaez, H Arnold, M Arratia, O Arslan, A Artamonov, G Artoni, S Artz, S Asai, N Asbah, A Ashkenazi, L Asquith, K Assamagan, R Astalos, R J Atkin, M Atkinson, N B Atlay, K Augsten, G Avolio, R Avramidou, B Axen, M K Ayoub, G Azuelos, A E Baas, M J Baca, H Bachacou, K Bachas, M Backes, P Bagnaia, M Bahmani, H Bahrasemani, J T Baines, M Bajic, O K Baker, P J Bakker, D Bakshi Gupta, E M Baldin, P Balek, F Balli, W K Balunas, E Banas, A Bandyopadhyay, Sw Banerjee, A A E Bannoura, L Barak, E L Barberio, D Barberis, M Barbero, T Barillari, M-S Barisits, J T Barkeloo, T Barklow, N Barlow, R Barnea, S L Barnes, B M Barnett, R M Barnett, Z Barnovska-Blenessy, A Baroncelli, G Barone, A J Barr, L Barranco Navarro, F Barreiro, J Barreiro Guimarães da Costa, R Bartoldus, A E Barton, P Bartos, A Basalaev, A Bassalat, R L Bates, S J Batista, J R Batley, M Battaglia, M Bauce, F Bauer, K T Bauer, H S Bawa, J B Beacham, M D Beattie, T Beau, P H Beauchemin, P Bechtle, H P Beck, H C Beck, K Becker, M Becker, C Becot, A J Beddall, A Beddall, V A Bednyakov, M Bedognetti, C P Bee, T A Beermann, M Begalli, M Begel, A Behera, J K Behr, A S Bell, G Bella, L Bellagamba, A Bellerive, M Bellomo, K Belotskiy, N L Belyaev, O Benary, D Benchekroun, M Bender, N Benekos, Y Benhammou, E Benhar Noccioli, J Benitez, D P Benjamin, M Benoit, J R Bensinger, S Bentvelsen, L Beresford, M Beretta, D Berge, E Bergeaas Kuutmann, N Berger, L J Bergsten, J Beringer, S Berlendis, N R Bernard, G Bernardi, C Bernius, F U Bernlochner, T Berry, P Berta, C Bertella, G Bertoli, I A Bertram, C Bertsche, G J Besjes, O Bessidskaia Bylund, M Bessner, N Besson, A Bethani, S Bethke, A Betti, A J Bevan, J Beyer, R M Bianchi, O Biebel, D Biedermann, R Bielski, K Bierwagen, N V Biesuz, M Biglietti, T R V Billoud, M Bindi, A Bingul, C Bini, S Biondi, T Bisanz, C Bittrich, D M Bjergaard, J E Black, K M Black, R E Blair, T Blazek, I Bloch, C Blocker, A Blue, U Blumenschein, Dr Blunier, G J Bobbink, V S Bobrovnikov, S S Bocchetta, A Bocci, C Bock, D Boerner, D Bogavac, A G Bogdanchikov, C Bohm, V Boisvert, P Bokan, T Bold, A S Boldyrev, A E Bolz, M Bomben, M Bona, J S Bonilla, M Boonekamp, A Borisov, G Borissov, J Bortfeldt, D Bortoletto, V Bortolotto, D Boscherini, M Bosman, J D Bossio Sola, J Boudreau, E V Bouhova-Thacker, D Boumediene, C Bourdarios, S K Boutle, A Boveia, J Boyd, I R Boyko, A J Bozson, J Bracinik, A Brandt, G Brandt, O Brandt, F Braren, U Bratzler, B Brau, J E Brau, W D Breaden Madden, K Brendlinger, A J Brennan, L Brenner, R Brenner, S Bressler, D L Briglin, T M Bristow, D Britton, D Britzger, I Brock, R Brock, G Brooijmans, T Brooks, W K Brooks, E Brost, J H Broughton, P A Bruckman de Renstrom, D Bruncko, A Bruni, G Bruni, L S Bruni, S Bruno, B H Brunt, M Bruschi, N Bruscino, P Bryant, L Bryngemark, T Buanes, Q Buat, P Buchholz, A G Buckley, I A Budagov, F Buehrer, M K Bugge, O Bulekov, D Bullock, T J Burch, S Burdin, C D Burgard, A M Burger, B Burghgrave, K Burka, S Burke, I Burmeister, J T P Burr, D Büscher, V Büscher, E Buschmann, P Bussey, J M Butler, C M Buttar, J M Butterworth, P Butti, W Buttinger, A Buzatu, A R Buzykaev, G Cabras, S Cabrera Urbán, D Caforio, H Cai, V M M Cairo, O Cakir, N Calace, P Calafiura, A Calandri, G Calderini, P Calfayan, G Callea, L P Caloba, S Calvente Lopez, D Calvet, S Calvet, T P Calvet, M Calvetti, R Camacho Toro, S Camarda, P Camarri, D Cameron, R Caminal Armadans, C Camincher, S Campana, M Campanelli, A Camplani, A Campoverde, V Canale, M Cano Bret, J Cantero, T Cao, Y Cao, M D M Capeans Garrido, I Caprini, M Caprini, M Capua, R M Carbone, R Cardarelli, F Cardillo, I Carli, T Carli, G Carlino, B T Carlson, L Carminati, R M D Carney, S Caron, E Carquin, S Carrá, G D Carrillo-Montoya, D Casadei, M P Casado, A F Casha, M Casolino, D W Casper, R Castelijn, V Castillo Gimenez, N F Castro, A Catinaccio, J R Catmore, A Cattai, J Caudron, V Cavaliere, E Cavallaro, D Cavalli, M Cavalli-Sforza, V Cavasinni, E Celebi, F Ceradini, L Cerda Alberich, A S Cerqueira, A Cerri, L Cerrito, F Cerutti, A Cervelli, S A Cetin, A Chafaq, D Chakraborty, S K Chan, W S Chan, Y L Chan, P Chang, J D Chapman, D G Charlton, C C Chau, C A Chavez Barajas, S Che, A Chegwidden, S Chekanov, S V Chekulaev, G A Chelkov, M A Chelstowska, C Chen, C Chen, H Chen, J Chen, J Chen, S Chen, S Chen, X Chen, Y Chen, H C Cheng, H J Cheng, A Cheplakov, E Cheremushkina, R Cherkaoui El Moursli, E Cheu, K Cheung, L Chevalier, V Chiarella, G Chiarelli, G Chiodini, A S Chisholm, A Chitan, I Chiu, Y H Chiu, M V Chizhov, K Choi, A R Chomont, S Chouridou, Y S Chow, V Christodoulou, M C Chu, J Chudoba, A J Chuinard, J J Chwastowski, L Chytka, D Cinca, V Cindro, I A Cioară, A Ciocio, F Cirotto, Z H Citron, M Citterio, A Clark, M R Clark, P J Clark, R N Clarke, C Clement, Y Coadou, M Cobal, A Coccaro, J Cochran, L Colasurdo, B Cole, A P Colijn, J Collot, P Conde Muiño, E Coniavitis, S H Connell, I A Connelly, S Constantinescu, G Conti, F Conventi, A M Cooper-Sarkar, F Cormier, K J R Cormier, M Corradi, E E Corrigan, F Corriveau, A Cortes-Gonzalez, M J Costa, D Costanzo, G Cottin, G Cowan, B E Cox, K Cranmer, S J Crawley, R A Creager, G Cree, S Crépé-Renaudin, F Crescioli, M Cristinziani, V Croft, G Crosetti, A Cueto, T Cuhadar Donszelmann, A R Cukierman, J Cummings, M Curatolo, J Cúth, S Czekierda, P Czodrowski, G D'amen, S D'Auria, L D'eramo, M D'Onofrio, M J Da Cunha Sargedas De Sousa, C Da Via, W Dabrowski, T Dado, S Dahbi, T Dai, O Dale, F Dallaire, C Dallapiccola, M Dam, J R Dandoy, M F Daneri, N P Dang, N S Dann, M Danninger, M Dano Hoffmann, V Dao, G Darbo, S Darmora, O Dartsi, A Dattagupta, T Daubney, W Davey, C David, T Davidek, D R Davis, P Davison, E Dawe, I Dawson, K De, R de Asmundis, A De Benedetti, S De Castro, S De Cecco, N De Groot, P de Jong, H De la Torre, F De Lorenzi, A De Maria, D De Pedis, A De Salvo, U De Sanctis, A De Santo, K De Vasconcelos Corga, J B De Vivie De Regie, C Debenedetti, D V Dedovich, N Dehghanian, I Deigaard, M Del Gaudio, J Del Peso, D Delgove, F Deliot, C M Delitzsch, A Dell'Acqua, L Dell'Asta, M Della Pietra, D Della Volpe, M Delmastro, C Delporte, P A Delsart, D A DeMarco, S Demers, M Demichev, S P Denisov, D Denysiuk, D Derendarz, J E Derkaoui, F Derue, P Dervan, K Desch, C Deterre, K Dette, M R Devesa, P O Deviveiros, A Dewhurst, S Dhaliwal, F A Di Bello, A Di Ciaccio, L Di Ciaccio, W K Di Clemente, C Di Donato, A Di Girolamo, B Di Micco, R Di Nardo, K F Di Petrillo, A Di Simone, R Di Sipio, D Di Valentino, C Diaconu, M Diamond, F A Dias, M A Diaz, J Dickinson, E B Diehl, J Dietrich, S Díez Cornell, A Dimitrievska, J Dingfelder, P Dita, S Dita, F Dittus, F Djama, T Djobava, J I Djuvsland, M A B do Vale, M Dobre, D Dodsworth, C Doglioni, J Dolejsi, Z Dolezal, M Donadelli, J Donini, J Dopke, A Doria, M T Dova, A T Doyle, E Drechsler, E Dreyer, M Dris, Y Du, J Duarte-Campderros, F Dubinin, A Dubreuil, E Duchovni, G Duckeck, A Ducourthial, O A Ducu, D Duda, A Dudarev, A Chr Dudder, E M Duffield, L Duflot, M Dührssen, C Dulsen, M Dumancic, A E Dumitriu, A K Duncan, M Dunford, A Duperrin, H Duran Yildiz, M Düren, A Durglishvili, D Duschinger, B Dutta, D Duvnjak, M Dyndal, B S Dziedzic, C Eckardt, K M Ecker, R C Edgar, T Eifert, G Eigen, K Einsweiler, T Ekelof, M El Kacimi, R El Kosseifi, V Ellajosyula, M Ellert, F Ellinghaus, A A Elliot, N Ellis, J Elmsheuser, M Elsing, D Emeliyanov, Y Enari, J S Ennis, M B Epland, J Erdmann, A Ereditato, S Errede, M Escalier, C Escobar, B Esposito, O Estrada Pastor, A I Etienvre, E Etzion, H Evans, A Ezhilov, M Ezzi, F Fabbri, L Fabbri, V Fabiani, G Facini, R M Fakhrutdinov, S Falciano, J Faltova, Y Fang, M Fanti, A Farbin, A Farilla, E M Farina, T Farooque, S Farrell, S M Farrington, P Farthouat, F Fassi, P Fassnacht, D Fassouliotis, M Faucci Giannelli, A Favareto, W J Fawcett, L Fayard, O L Fedin, W Fedorko, M Feickert, S Feigl, L Feligioni, C Feng, E J Feng, M Feng, M J Fenton, A B Fenyuk, L Feremenga, P Fernandez Martinez, J Ferrando, A Ferrari, P Ferrari, R Ferrari, D E Ferreira de Lima, A Ferrer, D Ferrere, C Ferretti, F Fiedler, A Filipčič, F Filthaut, M Fincke-Keeler, K D Finelli, M C N Fiolhais, L Fiorini, C Fischer, J Fischer, W C Fisher, N Flaschel, I Fleck, P Fleischmann, R R M Fletcher, T Flick, B M Flierl, L M Flores, L R Flores Castillo, N Fomin, G T Forcolin, A Formica, F A Förster, A Forti, A G Foster, D Fournier, H Fox, S Fracchia, P Francavilla, M Franchini, S Franchino, D Francis, L Franconi, M Franklin, M Frate, M Fraternali, D Freeborn, S M Fressard-Batraneanu, B Freund, W S Freund, D Froidevaux, J A Frost, C Fukunaga, T Fusayasu, J Fuster, O Gabizon, A Gabrielli, A Gabrielli, G P Gach, S Gadatsch, S Gadomski, P Gadow, G Gagliardi, L G Gagnon, C Galea, B Galhardo, E J Gallas, B J Gallop, P Gallus, G Galster, R Gamboa Goni, K K Gan, S Ganguly, Y Gao, Y S Gao, F M Garay Walls, C García, J E García Navarro, J A García Pascual, M Garcia-Sciveres, R W Gardner, N Garelli, V Garonne, K Gasnikova, A Gaudiello, G Gaudio, I L Gavrilenko, C Gay, G Gaycken, E N Gazis, C N P Gee, J Geisen, M Geisen, M P Geisler, K Gellerstedt, C Gemme, M H Genest, C Geng, S Gentile, C Gentsos, S George, D Gerbaudo, G Geßner, S Ghasemi, M Ghneimat, B Giacobbe, S Giagu, N Giangiacomi, P Giannetti, S M Gibson, M Gignac, M Gilchriese, D Gillberg, G Gilles, D M Gingrich, M P Giordani, F M Giorgi, P F Giraud, P Giromini, G Giugliarelli, D Giugni, F Giuli, M Giulini, S Gkaitatzis, I Gkialas, E L Gkougkousis, P Gkountoumis, L K Gladilin, C Glasman, J Glatzer, P C F Glaysher, A Glazov, M Goblirsch-Kolb, J Godlewski, S Goldfarb, T Golling, D Golubkov, A Gomes, R Gonçalo, R Goncalves Gama, G Gonella, L Gonella, A Gongadze, F Gonnella, J L Gonski, S González de la Hoz, S Gonzalez-Sevilla, L 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Soloshenko, O V Solovyanov, V Solovyev, P Sommer, H Son, W Song, A Sopczak, F Sopkova, D Sosa, C L Sotiropoulou, S Sottocornola, R Soualah, A M Soukharev, D South, B C Sowden, S Spagnolo, M Spalla, M Spangenberg, F Spanò, D Sperlich, F Spettel, T M Spieker, R Spighi, G Spigo, L A Spiller, M Spousta, R D St Denis, A Stabile, R Stamen, S Stamm, E Stanecka, R W Stanek, C Stanescu, M M Stanitzki, B S Stapf, S Stapnes, E A Starchenko, G H Stark, J Stark, S H Stark, P Staroba, P Starovoitov, S Stärz, R Staszewski, M Stegler, P Steinberg, B Stelzer, H J Stelzer, O Stelzer-Chilton, H Stenzel, T J Stevenson, G A Stewart, M C Stockton, G Stoicea, P Stolte, S Stonjek, A Straessner, M E Stramaglia, J Strandberg, S Strandberg, M Strauss, P Strizenec, R Ströhmer, D M Strom, R Stroynowski, A Strubig, S A Stucci, B Stugu, N A Styles, D Su, J Su, S Suchek, Y Sugaya, M Suk, V V Sulin, Dms Sultan, S Sultansoy, T Sumida, S Sun, X Sun, K Suruliz, C J E Suster, M R Sutton, S Suzuki, M Svatos, M Swiatlowski, S P Swift, A Sydorenko, I Sykora, T Sykora, D Ta, K Tackmann, J Taenzer, A Taffard, R Tafirout, E Tahirovic, N Taiblum, H Takai, R Takashima, E H Takasugi, K Takeda, T Takeshita, Y Takubo, M Talby, A A Talyshev, J Tanaka, M Tanaka, R Tanaka, R Tanioka, B B Tannenwald, S Tapia Araya, S Tapprogge, A T Tarek Abouelfadl Mohamed, S Tarem, G Tarna, G F Tartarelli, P Tas, M Tasevsky, T Tashiro, E Tassi, A Tavares Delgado, Y Tayalati, A C Taylor, A J Taylor, G N Taylor, P T E Taylor, W Taylor, P Teixeira-Dias, D Temple, H Ten Kate, P K Teng, J J Teoh, F Tepel, S Terada, K Terashi, J Terron, S Terzo, M Testa, R J Teuscher, S J Thais, T Theveneaux-Pelzer, F Thiele, J P Thomas, P D Thompson, A S Thompson, L A Thomsen, E Thomson, Y Tian, R E Ticse Torres, V O Tikhomirov, Yu A Tikhonov, S Timoshenko, P Tipton, S Tisserant, K Todome, S Todorova-Nova, S Todt, J Tojo, S Tokár, K Tokushuku, E Tolley, M Tomoto, L Tompkins, K Toms, B Tong, P Tornambe, E Torrence, H Torres, E Torró Pastor, J Toth, F Touchard, D R Tovey, C J Treado, T Trefzger, F Tresoldi, A Tricoli, I M Trigger, S Trincaz-Duvoid, M F Tripiana, W Trischuk, B Trocmé, A Trofymov, C Troncon, M Trovatelli, L Truong, M Trzebinski, A Trzupek, K W Tsang, J C-L Tseng, P V Tsiareshka, N Tsirintanis, S Tsiskaridze, V Tsiskaridze, E G Tskhadadze, I I Tsukerman, V Tsulaia, S Tsuno, D Tsybychev, Y Tu, A Tudorache, V Tudorache, T T Tulbure, A N Tuna, S Turchikhin, D Turgeman, I Turk Cakir, R Turra, P M Tuts, G Ucchielli, I Ueda, M Ughetto, F Ukegawa, G Unal, A Undrus, G Unel, F C Ungaro, Y Unno, K Uno, J Urban, P Urquijo, P Urrejola, G Usai, J Usui, L Vacavant, V Vacek, B Vachon, K O H Vadla, A Vaidya, C Valderanis, E Valdes Santurio, M Valente, S Valentinetti, A Valero, L Valéry, A Vallier, J A Valls Ferrer, W Van Den Wollenberg, H van der Graaf, P van Gemmeren, J Van Nieuwkoop, I van Vulpen, M C van Woerden, M Vanadia, W Vandelli, A Vaniachine, P Vankov, R Vari, E W Varnes, C Varni, T Varol, D Varouchas, A Vartapetian, K E Varvell, J G Vasquez, G A Vasquez, F Vazeille, D Vazquez Furelos, T Vazquez Schroeder, J Veatch, L M Veloce, F Veloso, S Veneziano, A Ventura, M Venturi, N Venturi, V Vercesi, M Verducci, W Verkerke, A T Vermeulen, J C Vermeulen, M C Vetterli, N Viaux Maira, O Viazlo, I Vichou, T Vickey, O E Vickey Boeriu, G H A Viehhauser, S Viel, L Vigani, M Villa, M Villaplana Perez, E Vilucchi, M G Vincter, V B Vinogradov, A Vishwakarma, C Vittori, I Vivarelli, S Vlachos, M Vogel, P Vokac, G Volpi, S E von Buddenbrock, E von Toerne, V Vorobel, K Vorobev, M Vos, J H Vossebeld, N Vranjes, M Vranjes Milosavljevic, V Vrba, M Vreeswijk, R Vuillermet, I Vukotic, P Wagner, W Wagner, J Wagner-Kuhr, H Wahlberg, S Wahrmund, K Wakamiya, J Walder, R Walker, W Walkowiak, V Wallangen, A M Wang, C Wang, F Wang, H Wang, H Wang, J Wang, J Wang, Q Wang, R-J Wang, R Wang, S M Wang, T Wang, W Wang, W Wang, Z Wang, C Wanotayaroj, A Warburton, C P Ward, D R Wardrope, A Washbrook, P M Watkins, A T Watson, M F Watson, G Watts, S Watts, B M Waugh, A F Webb, S Webb, M S Weber, S M Weber, S A Weber, J S Webster, A R Weidberg, B Weinert, J Weingarten, M Weirich, C Weiser, P S Wells, T Wenaus, T Wengler, S Wenig, N Wermes, M D Werner, P Werner, M Wessels, T D Weston, K Whalen, N L Whallon, A M Wharton, A S White, A White, M J White, R White, D Whiteson, B W Whitmore, F J Wickens, W Wiedenmann, M Wielers, C Wiglesworth, L A M Wiik-Fuchs, A Wildauer, F Wilk, H G Wilkens, H H Williams, S Williams, C Willis, S Willocq, J A Wilson, I Wingerter-Seez, E Winkels, F Winklmeier, O J Winston, B T Winter, M Wittgen, M Wobisch, A Wolf, T M H Wolf, R Wolff, M W Wolter, H Wolters, V W S Wong, N L Woods, S D Worm, B K Wosiek, K W Wozniak, M Wu, S L Wu, X Wu, Y Wu, T R Wyatt, B M Wynne, S Xella, Z Xi, L Xia, D Xu, H Xu, L Xu, T Xu, W Xu, B Yabsley, S Yacoob, K Yajima, D P Yallup, D Yamaguchi, Y Yamaguchi, A Yamamoto, T Yamanaka, F Yamane, M Yamatani, T Yamazaki, Y Yamazaki, Z Yan, H Yang, H Yang, S Yang, Y Yang, Y Yang, Z Yang, W-M Yao, Y C Yap, Y Yasu, E Yatsenko, K H Yau Wong, J Ye, S Ye, I Yeletskikh, E Yigitbasi, E Yildirim, K Yorita, K Yoshihara, C Young, C J S Young, J Yu, J Yu, S P Y Yuen, I Yusuff, B Zabinski, G Zacharis, R Zaidan, A M Zaitsev, N Zakharchuk, J Zalieckas, S Zambito, D Zanzi, C Zeitnitz, G Zemaityte, J C Zeng, Q Zeng, O Zenin, T Ženiš, D Zerwas, D Zhang, D Zhang, F Zhang, G Zhang, H Zhang, J Zhang, L Zhang, L Zhang, M Zhang, P Zhang, R Zhang, R Zhang, X Zhang, Y Zhang, Z Zhang, X Zhao, Y Zhao, Z Zhao, A Zhemchugov, B Zhou, C Zhou, L Zhou, M Zhou, M Zhou, N Zhou, Y Zhou, C G Zhu, H Zhu, J Zhu, Y Zhu, X Zhuang, K Zhukov, V Zhulanov, A Zibell, D Zieminska, N I Zimine, S Zimmermann, Z Zinonos, M Zinser, M Ziolkowski, L Živković, G Zobernig, A Zoccoli, T G Zorbas, R Zou, M Zur Nedden, L Zwalinski
A direct search for the standard model Higgs boson decaying to a pair of charm quarks is presented. Associated production of the Higgs and Z bosons, in the decay mode ZH→ℓ^{+}ℓ^{-}cc[over ¯] is studied. A data set with an integrated luminosity of 36.1  fb^{-1} of pp collisions at sqrt[s]=13TeV recorded by the ATLAS experiment at the LHC is used. The H→cc[over ¯] signature is identified using charm-tagging algorithms. The observed (expected) upper limit on σ(pp→ZH)×B(H→cc[over ¯]) is 2.7 (3...
May 25, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29880301/effectiveness-of-targeted-enhanced-terminal-room-disinfection-on-hospital-wide-acquisition-and-infection-with-multidrug-resistant-organisms-and-clostridium-difficile-a-secondary-analysis-of-a-multicentre-cluster-randomised-controlled-trial-with-crossover-design
#18
Deverick J Anderson, Rebekah W Moehring, David J Weber, Sarah S Lewis, Luke F Chen, J Conrad Schwab, Paul Becherer, Michael Blocker, Patricia F Triplett, Lauren P Knelson, Yuliya Lokhnygina, William A Rutala, Daniel J Sexton
BACKGROUND: The hospital environment is a source of pathogen transmission. The effect of enhanced disinfection strategies on the hospital-wide incidence of infection has not been investigated in a multicentre, randomised controlled trial. We aimed to assess the effectiveness of four disinfection strategies on hospital-wide incidence of multidrug-resistant organisms and Clostridium difficile in the Benefits of Enhanced Terminal Room (BETR) Disinfection study. METHODS: We did a prespecified secondary analysis of the results from the BETR Disinfection study, a pragmatic, multicentre, crossover cluster-randomised trial that assessed four different strategies for terminal room disinfection in nine hospitals in the southeastern USA...
June 4, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29878933/challenges-in-pathologic-staging-of-renal-cell-carcinoma-a-study-of-interobserver-variability-among-urologic-pathologists
#19
Sean R Williamson, Priya Rao, Ondrej Hes, Jonathan I Epstein, Steven C Smith, Maria M Picken, Ming Zhou, Maria S Tretiakova, Satish K Tickoo, Ying-Bei Chen, Victor E Reuter, Stewart Fleming, Fiona M Maclean, Nilesh S Gupta, Naoto Kuroda, Brett Delahunt, Rohit Mehra, Christopher G Przybycin, Liang Cheng, John N Eble, David J Grignon, Holger Moch, Jose I Lopez, Lakshmi P Kunju, Pheroze Tamboli, John R Srigley, Mahul B Amin, Guido Martignoni, Michelle S Hirsch, Stephen M Bonsib, Kiril Trpkov
Staging criteria for renal cell carcinoma differ from many other cancers, in that renal tumors are often spherical with subtle, finger-like extensions into veins, renal sinus, or perinephric tissue. We sought to study interobserver agreement in pathologic stage categories for challenging cases. An online survey was circulated to urologic pathologists interested in kidney tumors, yielding 89% response (31/35). Most questions included 1 to 4 images, focusing on: vascular and renal sinus invasion (n=24), perinephric invasion (n=9), and gross pathology/specimen handling (n=17)...
June 6, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29878078/aa9int-snp-interaction-pattern-search-using-non-hierarchical-additive-model-set
#20
Hui-Yi Lin, Po-Yu Huang, Dung-Tsa Chen, Heng-Yuan Tung, Thomas A Sellers, Julio Pow-Sang, Rosalind Eeles, Doug Easton, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch, Kenneth Muir, Graham G Giles, Fredrik Wiklund, Henrik Gronberg, Christopher A Haiman, Johanna Schleutker, Børge G Nordestgaard, Ruth C Travis, Freddie Hamdy, David E Neal, Nora Pashayan, Kay-Tee Khaw, Janet L Stanford, William J Blot, Stephen N Thibodeau, Christiane Maier, Adam S Kibel, Cezary Cybulski, Lisa Cannon-Albright, Hermann Brenner, Radka Kaneva, Jyotsna Batra, Manuel R Teixeira, Hardev Pandha, Yong-Jie Lu, Jong Y Park
Motivation: The use of single nucleotide polymorphism (SNP) interactions to predict complex diseases is getting more attention during the past decade, but related statistical methods are still immature. We previously proposed the SNP Interaction Pattern Identifier (SIPI) approach to evaluate 45 SNP interaction patterns/patterns. SIPI is statistically powerful but suffers from a large computation burden. For large-scale studies, it is necessary to use a powerful and computation-efficient method...
June 7, 2018: Bioinformatics
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