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https://www.readbyqxmd.com/read/28298753/a-prospective-randomized-trial-comparing-dexmedetomidine-and-midazolam-for-conscious-sedation-during-oocyte-retrieval-in-an-in-vitro-fertilization-program
#1
Ali Mohamed Ali Elnabtity, Mohamed Fouad Selim
BACKGROUND: Various sedative and analgesic techniques have been used for pain relief during oocyte retrieval which is the most painful part of in vitro fertilization (IVF) procedures. AIM: This study aimed at comparing dexmedetomidine and midazolam for conscious sedation in women undergoing transvaginal oocyte retrieval during an IVF program. SETTINGS AND DESIGN: Prospective randomized double-blinded comparative study. PATIENTS AND METHODS: Fifty-two patients undergoing oocyte retrieval in their first IVF cycle were randomly allocated into two equal groups...
January 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28285261/catalase-as-a-sulfide-sulfur-oxido-reductase-an-ancient-and-modern-regulator-of-reactive-sulfur-species-rss
#2
Kenneth R Olson, Yan Gao, Eric R DeLeon, Maaz Arif, Faihaan Arif, Nitin Arora, Karl D Straub
Catalase is well-known as an antioxidant dismutating H2O2 to O2 and H2O. However, catalases evolved when metabolism was largely sulfur-based, long before O2 and reactive oxygen species (ROS) became abundant, suggesting catalase metabolizes reactive sulfide species (RSS). Here we examine catalase metabolism of H2Sn, the sulfur analog of H2O2, hydrogen sulfide (H2S) and other sulfur-bearing molecules using H2S-specific amperometric electrodes and fluorophores to measure polysulfides (H2Sn; SSP4) and ROS (dichlorofluorescein, DCF)...
March 1, 2017: Redox Biology
https://www.readbyqxmd.com/read/28283018/tramadol-vs-dexmedetomidine-for-emergence-agitation-control-in-pediatric-patients-undergoing-adenotonsillectomy-with-sevoflurane-anesthesia-prospective-randomized-controlled-clinical-study
#3
Nurdan Bedirli, Mehmet Akçabay, Ulku Emik
BACKGROUND: This study was designed to compare the efficacy of an intraoperative single dose administration of tramadol and dexmedetomidine on hemodynamics and postoperative recovery profile including pain, sedation, emerge reactions in pediatric patients undergoing adenotonsillectomy with sevoflurane anesthesia. METHODS: Seventy-seven patient, aged 2-12, undergoing adenotonsillectomy with sevoflurane anesthesia was enrolled in this study. Patients were randomly assigned to receive either intravenous 2 mg/kg tramadol (Group T; n = 39) or 1 μg/kg dexmedetomidine (Group D; n = 38) after intubation...
March 11, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28269717/assessment-of-sedation-analgesia-by-means-of-poincare%C3%AC-analysis-of-the-electroencephalogram
#4
Jose D Bolanos, Montserrat Vallverdu, Pere Caminal, Daniel F Valencia, Xavi Borrat, Pedro L Gambus, Jose F Valencia
Monitoring the levels of sedation-analgesia may be helpful for managing patient stress on minimally invasive medical procedures. Monitors based on EEG analysis and designed to assess general anesthesia cannot distinguish reliably between a light and deep sedation. In this work, the Poincaré plot is used as a nonlinear technique applied to EEG signals in order to characterize the levels of sedation-analgesia, according to observed categorical responses that were evaluated by means of Ramsay Sedation Scale (RSS)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28262184/resting-state-synchrony-in-long-term-abstinent-alcoholics-effects-of-a-current-major-depressive-disorder-diagnosis
#5
George Fein, Jazmin Camchong, Valerie A Cardenas, Andy Stenger
Alcoholism is characterized by a lack of control over an impulsive and compulsive drive toward excessive alcohol consumption despite significant negative consequences; our previous work demonstrated that successful abstinence is characterized by decreased resting-state synchrony (RSS) as measured with functional magnetic resonance imaging (fMRI), within appetitive drive networks and increased RSS in emotion regulation and inhibitory executive control networks. Our hypothesis is that LTAA (Long-Term Abstinent Alcoholics) with a current major depressive disorder (MDD) drank primarily to deal with the negative affect associated with their MDD and not because of a heightened externalizing diathesis (including heightened appetitive drive), and consequently, in achieving and maintaining abstinence, such individuals would not exhibit the RSS adaptations characteristic of pure alcoholics...
March 2017: Alcohol
https://www.readbyqxmd.com/read/28260288/-usefulness-of-the-residual-syntax-score-to-predict-long-term-outcome-in-acute-coronary-syndrome-patients-underwent-percutaneous-coronary-intervention
#6
Y Song, J J Xu, X F Tang, Y L Ma, Y Yao, C He, H H Wang, R Liu, N Xu, P Jiang, L Jiang, X Y Zhao, Z Gao, R L Gao, S B Qiao, Y J Yang, B Xu, J Q Yuan
Objective: To quantify the extent and complexity of residual coronary stenosis following PCI by the residual SYNTAX score, and to evaluate its impact on adverse ischemic outcomes in acute coronary syndrome(ACS) patients. Methods: From January 2013 to December 2013, a total of 1 414 consecutive moderate- and high-risk ACS patients who underwent any PCI with multi-vessel coronary artery disease were evaluated.Patients were stratified by rSS quartiles and their outcomes were compared. Results: The rSS was 4.8±6...
February 21, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28255078/impacts-of-renal-sympathetic-activation-on-atrial-fibrillation-the-potential-role-of-the-autonomic-cross-talk-between-kidney-and-heart
#7
Lilei Yu, Bing Huang, Zhuo Wang, Songyun Wang, Menglong Wang, Xuefei Li, Liping Zhou, Guannan Meng, Shenxu Yuan, Xiaoya Zhou, Hong Jiang
BACKGROUND: Recent studies have demonstrated that there is a high variability of renal sympathetic nerve density distribution from proximal to distal renal artery segments. The aim of our study was to investigate the roles of renal sympathetic nerve stimulation (RSS) on atrial fibrillation and cardiac autonomic nervous activity. METHODS AND RESULTS: Twenty-eight dogs were randomly assigned to the proximal RSS group (P-RSS, N=7), middle RSS group (M-RSS, N=7), distal RSS group (D-RSS, N=7), and the control group (sham RSS, N=7)...
March 2, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28252936/fluorescence-approach-for-the-determination-of-fluorescent-dissolved-organic-matter
#8
Chen Qian, Long-Fei Wang, Wei Chen, Yan-Shan Wang, Xiao-Yang Liu, Hong Jiang, Han-Qing Yu
Excitation-emission matrix (EEM) fluorescence spectroscopy coupled with parallel factor (PARAFAC) analysis has been widely applied to characterize dissolved organic matter (DOM) in aquatic and terrestrial systems. However, its application in environmental samples is limited because PARAFAC is not able to handle nontrilinear EEM data, leading to the overestimated number of components and incorrect decomposition results. In this work, a new method, parallel factor framework-clustering analysis (PFFCA), is proposed to resolve this problem...
March 14, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28249614/effect-of-dexmedetomidine-combined-with-sufentanil-for-post-thoracotomy-intravenous-analgesia-a-randomized-controlled-clinical-study
#9
Chun-Shan Dong, Jun Zhang, Qiang Lu, Peng Sun, Jun-Ma Yu, Chao Wu, Hao Sun
BACKGROUND: Few studies have investigated the use of dexmedetomidine in patient-controlled intravenous analgesia (PCIA) after thoracic surgery. This study to evaluate the effect of dexmedetomidine combined with sufentanil for PCIA after thoracotomy under general anaesthesia. METHODS: Ninety-seven adults patients scheduled for thoracotomy surgery. All two groups received PCIA with either sufentanil alone (control group) or combining dexmedetomidine with sufentanil (dexmedetomidine group)...
March 1, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28242583/clinical-implications-of-the-residual-syntax-score-after-percutaneous-coronary-intervention-in-patients-with-chronic-total-occlusion-and-multi-vessel-coronary-artery-disease-a-comparison-with-coronary-artery-bypass-grafting
#10
Woo Jin Jang, Jeong Hoon Yang, Young Bin Song, Joo-Yong Hahn, Jin-Ho Choi, Woo Jung Chun, Ju Hyeon Oh, Yong Hwan Park, Wook Sung Kim, Young Tak Lee, Hyeon-Cheol Gwon, Seung-Hyuk Choi
AIMS: We evaluated clinical impact of residual SYNTAX score (rSS) after percutaneous coronary intervention (PCI) in patients with chronic total occlusion (CTO) and multi-vessel coronary artery disease (CAD). METHODS AND RESULTS: We analyzed data from 1,043 patients with CTO and multi-vessel CAD who were treated with PCI or coronary artery bypass grafting (CABG). Patients were divided into three groups: patients with rSS≤12 after PCI (rSS≤12 group, n=445), patients with rSS>12 after PCI (rSS>12 group, n=150), and patients who underwent CABG (CABG group, n=448)...
February 28, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28235888/adaptation-of-candida-albicans-to-reactive-sulfur-species
#11
Yasmin Chebaro, Michael Lorenz, Alice Fa, Rui Zheng, Michael Gustin
Candida albicans is an opportunistic fungal pathogen that is highly resistant to different oxidative stresses. How reactive sulfur species (RSS) such as sulfite regulate gene expression and the role of the transcription factor Zcf2 and the sulfite exporter Ssu1 in such responses is not known. Here, we show that C. albicans specifically adapts to sulfite stress and that Zcf2 is required for that response as well as induction of genes predicted to remove sulfite from cells and to increase the intracellular amount of a subset of nitrogen metabolites...
February 24, 2017: Genetics
https://www.readbyqxmd.com/read/28227981/assessment-of-sedation-analgesia-by-means-of-poincare%C3%AC-analysis-of-the-electroencephalogram
#12
Jose D Bolanos, Montserrat Vallverdu, Pere Caminal, Daniel F Valencia, Xavi Borrat, Pedro L Gambus, Jose F Valencia, Jose D Bolanos, Montserrat Vallverdu, Pere Caminal, Daniel F Valencia, Xavi Borrat, Pedro L Gambus, Jose F Valencia, Jose D Bolanos, Xavi Borrat, Jose F Valencia, Montserrat Vallverdu, Pere Caminal, Pedro L Gambus, Daniel F Valencia
Monitoring the levels of sedation-analgesia may be helpful for managing patient stress on minimally invasive medical procedures. Monitors based on EEG analysis and designed to assess general anesthesia cannot distinguish reliably between a light and deep sedation. In this work, the Poincaré plot is used as a nonlinear technique applied to EEG signals in order to characterize the levels of sedation-analgesia, according to observed categorical responses that were evaluated by means of Ramsay Sedation Scale (RSS)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28216706/monitored-anaesthesia-care-comparison-of-nalbuphine-dexmedetomidine-versus-nalbuphine-propofol-for-middle-ear-surgeries-a-double-blind-randomised-trial
#13
Srinivasa Rao Nallam, Sunil Chiruvella, Anjineswar Reddy
BACKGROUND AND AIMS: Middle ear surgeries (MESs) are usually performed under sedation with local anaesthesia and can be well tolerated by the patient with minimal discomfort. In the present study, we compare the effect of nalbuphine/dexmedetomidine combination with nalbuphine/propofol on sedation and analgesia in monitored anaesthesia care. METHODS: One hundred adult patients undergoing MESs under monitored anaesthesia care (MAC) were randomly allocated into two groups...
January 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/28212297/inorganic-reactive-sulfur-nitrogen-species-intricate-release-mechanisms-or-cacophony-in-yellow-blue-and-red
#14
Marian Grman, Muhammad Jawad Nasim, Roman Leontiev, Anton Misak, Veronika Jakusova, Karol Ondrias, Claus Jacob
Since the heydays of Reactive Sulfur Species (RSS) research during the first decade of the Millennium, numerous sulfur species involved in cellular regulation and signalling have been discovered. Yet despite the general predominance of organic species in organisms, recent years have also seen the emergence of inorganic reactive sulfur species, ranging from inorganic polysulfides (HSx(-)/Sx(2-)) to thionitrous acid (HSNO) and nitrosopersulfide (SSNO(-)). These inorganic species engage in a complex interplay of reactions in vitro and possibly also in vivo...
February 15, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28211603/impact-of-six-versus-12-months-of-dual-antiplatelet-therapy-in-patients-with-drug-eluting-stent-implantation-after-risk-stratification-with-the-residual-syntax-score-results-from-a-secondary-analysis-of-the-i-love-it-2-trial
#15
RANDOMIZED CONTROLLED TRIAL
Miaohan Qiu, Yi Li, Jing Li, Kai Xu, Quanmin Jing, Shaohong Dong, Zhe Jin, Pitian Zhao, Bo Xu, Yaling Han
BACKGROUND: The optimal duration of dual antiplatelet therapy (DAPT) after drug-eluting stent (DES) implantation remains undetermined, especially for those at high risk of cardiac events postprocedure. OBJECTIVES: This study was aimed to investigate the impact of 6 versus 12 months of DAPT after DES implantation based on risk stratification with the residual SYNTAX score (rSS). METHODS: A total of 2737 patients in the I-LOVE-IT 2 trial were grouped according to rSS status (low rSS [rSS = 0, n = 1474] versus high rSS [rSS > 0, n = 1263]) and DAPT duration (6 months vs...
March 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28209058/rare-sugar-syrup-containing-d-allulose-but-not-high-fructose-corn-syrup-maintains-glucose-tolerance-and-insulin-sensitivity-partly-via-hepatic-glucokinase-translocation-in-wistar-rats
#16
Tomoya Shintani, Takako Yamada, Noriko Hayashi, Tetsuo Iida, Yasuo Nagata, Nobuaki Ozaki, Yukiyasu Toyoda
Ingestion of high-fructose corn syrup (HFCS) is associated with the risk of both diabetes and obesity. Rare sugar syrup (RSS) has been developed by alkaline isomerization of HFCS and has anti-obesity and anti-diabetic effects. However, the influence of RSS on glucose metabolism has not been explored. We investigated whether long-term administration of RSS maintains glucose tolerance and whether the underlying mechanism involves hepatic glucokinase translocation. Wistar rats were administered water, RSS, or HFCS in drinking water for 10 weeks and then evaluated for glucose tolerance, insulin tolerance, liver glycogen content, and subcellular distribution of liver glucokinase...
March 9, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28176426/modeling-of-s-nitrosothiol-thiol-reactions-of-biological-significance-hno-production-via-s-thiolation-requires-a-proton-shuttle-and-stabilization-of-polar-intermediates
#17
Lena V Ivanova, Daniel Cibich, Gregory Deye, Marat R Talipov, Qadir Timerghazin
Nitroxyl HNO, a reduced form of an important gasotransmitter nitric oxide, exhibits its own unique biological activity. A possible biological pathway of HNO formation is S-thiolation reaction between thiols and S-nitrosothiols (RSNOs). Our DFT calculations suggests that S-thiolation proceeds through a proton transfer from thiol to the RSNO nitrogen atom, which increases electrophilicity of the RSNO sulfur, followed by nucleophilic attack by thiol yielding a charge-separated zwitterionic intermediate structure RSS+(R)N(H)O- (Zi), that decomposes yielding HNO and disulfide RSSR...
February 7, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28165423/a-novel-physical-layer-assisted-authentication-scheme-for-mobile-wireless-sensor-networks
#18
Qiuhua Wang
Physical-layer authentication can address physical layer vulnerabilities and security threats in wireless sensor networks, and has been considered as an effective complementary enhancement to existing upper-layer authentication mechanisms. In this paper, to advance the existing research and improve the authentication performance, we propose a novel physical layer assisted authentication scheme for mobile wireless sensor networks. In our proposed scheme, we explore the reciprocity and spatial uncorrelation of the wireless channel to verify the identities of involved transmitting users and decide whether all data frames are from the same sender...
February 4, 2017: Sensors
https://www.readbyqxmd.com/read/28163694/hand-to-face-remapping-but-no-differences-in-temporal-discrimination-observed-on-the-intact-hand-following-unilateral-upper-limb-amputation
#19
Kassondra L Collins, Danielle L McKean, Katherine Huff, Mark Tommerdahl, Oleg Vyacheslavovich Favorov, Robert S Waters, Jack W Tsao
Unilateral major limb amputation causes changes in sensory perception. Changes may occur within not only the residual limb but also the intact limb as well as the brain. We tested the hypothesis that limb amputation may result in the detection of hand sensation during stimulation of a non-limb-related body region. We further investigated the responses of unilateral upper limb amputees and individuals with all limbs intact to temporally based sensory tactile testing of the fingertips to test the hypothesis that changes in sensory perception also have an effect on the intact limb...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28153308/dual-functional-fluorescent-probe-responds-to-hypochlorous-acid-and-so2-derivatives-with-different-fluorescence-signals
#20
Hui Yu, Yongna Wu, Yue Hu, Xudong Gao, Qing Liang, Jian Xu, Shijun Shao
In view of the important roles of reactive oxygen species (ROS) and reactive sulfur species (RSS) in the complex signal transduction and oxidation pathways, fluorescent probes that are able to display distinct signals to hypochlorous acid and SO2 derivatives are highly valuable. Herein, a novel dual-functional probe (DFP) as an efficient single fluorescent-molecule which can respond to HClO and HSO3(-) with two different sets of fluorescence signals was presented. The DFP displayed desired properties such as high specificity, suitable sensitivity, appreciable water solubility and stability...
April 1, 2017: Talanta
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