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https://www.readbyqxmd.com/read/29040960/a-novel-s-sulfhydrated-human-serum-albumin-preparation-suppresses-melanin-synthesis
#1
Mayumi Ikeda, Yu Ishima, Ryo Kinoshita, Victor T G Chuang, Nanami Tasaka, Nana Matsuo, Hiroshi Watanabe, Taro Shimizu, Tatsuhiro Ishida, Masaki Otagiri, Toru Maruyama
Products of ultraviolet (UV) irradiation such as reactive oxygen species (ROS) and nitric oxide (NO) stimulate melanin synthesis. Reactive sulfur species (RSS) have been shown to have strong ROS and NO scavenging effects. However, the instability and low retention of RSS limit their use as inhibitors of melanin synthesis. The free thiol at Cys34 on human serum albumin (HSA) is highly stable, has a long retention and possess a high reactivity for RSS. We report herein on the development of an HSA based RSS delivery system...
October 11, 2017: Redox Biology
https://www.readbyqxmd.com/read/29033919/adaptation-of-methanogenic-inocula-to-anaerobic-digestion-of-maize-silage
#2
Martyna Wojcieszak, Adam Pyzik, Krzysztof Poszytek, Pawel S Krawczyk, Adam Sobczak, Leszek Lipinski, Otton Roubinek, Jacek Palige, Aleksandra Sklodowska, Lukasz Drewniak
A well-balanced microbial consortium is crucial for efficient biogas production. In turn, one of a major factor that influence on the structure of anaerobic digestion (AD) consortium is a source of microorganisms which are used as an inoculum. This study evaluated the influence of inoculum sources (with various origin) on adaptation of a biogas community and the efficiency of the biomethanization of maize silage. As initial inocula for AD of maize silage the samples from: (i) an agricultural biogas plant (ABP) which utilizes maize silage as a main substrate, (ii) cattle slurry (CS), which contain elevated levels of lignocelluloses materials, and (iii) raw sewage sludge (RSS) with low content of plant origin materials were used...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29033355/evaluation-of-the-effect-of-serratus-anterior-plane-block-for-pain-treatment-after-video-assisted-thoracoscopic-surgery
#3
Korgun Okmen, Burcu Metin Okmen
BACKGROUND: Analgesia following video-assisted thoracoscopic surgery (VATS) is important for the prevention of postoperative pulmonary complications. Various regional methods of anaesthesia are currently being used to achieve this goal. In our study, we aim to assess the effectiveness of SAPB on postoperative VATS analgesia in our study. METHODS: A total of 40 patients aged between 18 and 70 years, those who were in the Society of Anaesthesiologists (ASA) I-III class and underwent VATS were included in the study...
October 12, 2017: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/29031533/structural-changes-in-brain-morphology-induced-by-brief-periods-of-repetitive-sensory-stimulation
#4
T Schmidt-Wilcke, N Wulms, S Heba, B Pleger, N A Puts, B Glaubitz, T Kalisch, M Tegenthoff, H R Dinse
There is a growing interest in identifying the neural mechanisms by which the human brain allows for improving performance. Tactile perceptual measurements, e.g. two-point discrimination (2ptD), can be used to investigate neural mechanisms of perception as well as perceptual improvement. Improvement can be induced in a practice-independent manner, e.g. in the tactile domain through repetitive somatosensory stimulation (rSS). With respect to tactile perception, the role of cortical excitability and activation within the somatosensory cortex has been investigated extensively...
October 11, 2017: NeuroImage
https://www.readbyqxmd.com/read/29028975/comparative-responses-of-rhagoletis-zephyria-and-rhagoletis-pomonella-diptera-tephritidae-to-commercial-and-experimental-sticky-traps-and-odors-in-washington-state
#5
Wee L Yee, Robert B Goughnour, Jeffrey L Feder, Charles E Linn, Dong H Cha
Rhagoletis zephyria Snow and Rhagoletis pomonella (Walsh) (Diptera: Tephritidae) are morphologically similar flies that attack white-colored snowberry fruit (Symphoricarpos spp.) and yellow/red or dark-colored apple/hawthorn fruit (Malus/Crataegus spp.), respectively. The two flies are caught together on traps in R. pomonella surveys in the western United States, increasing labor needed to process catches. Comparing responses of the two species with different traps could help identify best practices for reducing R...
September 23, 2017: Environmental Entomology
https://www.readbyqxmd.com/read/29021224/a-violaxanthin-de-epoxidase-interacts-with-a-viral-suppressor-of-rna-silencing-to-inhibit-virus-amplification
#6
Ling Chen, Zhaoling Yan, Zihao Xia, Yuqin Cheng, Zhiyuan Jiao, Biao Sun, Tao Zhou, Zaifeng Fan
RNA silencing plays a critical role against viral infection. To counteract this antiviral silencing, viruses have evolved various RNA silencing suppressors. Meanwhile, plants have evolved counter-counter defense strategies against RNA silencing suppression (RSS). In this study, the violaxanthin de-epoxidase protein of maize (Zea mays L.) (ZmVDE) was shown to interact specifically with the helper component-proteinase (HC-Pro, a viral RNA silencing suppressor) of Sugarcane mosaic virus (SCMV) via its mature protein region by yeast two-hybrid assay, which was confirmed by co-immunoprecipitation in Nicotiana benthamiana cells...
October 11, 2017: Plant Physiology
https://www.readbyqxmd.com/read/29016475/relationship-between-physiological-off-ice-testing-on-ice-skating-and-game-performance-in-division-i-women-s-ice-hockey-players
#7
Michelle Boland, Emily M Miele, Katie Delude
The purpose was to identify off-ice testing variables that correlate to skating and game performance in Division I collegiate women ice hockey players. Twenty female, forward and defensive players (19.95 ± 1.35 yr) were assessed for weight, height, percent fat mass (%FAT), bone mineral density, predicted one repetition maximum (RM) absolute and relative (REL%) bench press (BP) and hex bar deadlift (HDL), lower body explosive power, anaerobic power, countermovement vertical jump (CMJ), maximum inspiratory pressure (MIP), and on-ice repeated skate sprint (RSS) performance...
October 7, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28993069/discrimination-of-subjective-responses-between-contact-lenses-with-a-novel-questionnaire
#8
Jennie Diec, Thomas Naduvilath, Daniel Tilia, Eric B Papas, Percy Lazon de la Jara
PURPOSE: To describe a ranked symptoms scale (RSS) discriminating subjective responses in contact lens (CL) wear in various situations. METHOD: Forty experienced clinical trial participants were interviewed for their perceptions of ocular comfort scales, resulting in a numerical RSS. For further evaluation, 20 CL wearers enrolled into a prospective, randomised, crossover trial. Two silicone-hydrogel CLs and a lens care solution (LCS) [Combinations A & B] were selected based on prior performance identifying best/worst combinations for end-of-day comfort...
October 6, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28989659/a-multi-signal-fluorescent-probe-for-simultaneously-distinguishing-and-sequentially-sensing-cysteine-homocysteine-glutathione-and-hydrogen-sulfide-in-living-cells
#9
Longwei He, Xueling Yang, Kaixin Xu, Xiuqi Kong, Weiying Lin
Biothiols, which have a close network of generation and metabolic pathways among them, are essential reactive sulfur species (RSS) in the cells and play vital roles in human physiology. However, biothiols possess highly similar chemical structures and properties, resulting in it being an enormous challenge to simultaneously discriminate them from each other. Herein, we develop a unique fluorescent probe (HMN) for not only simultaneously distinguishing Cys/Hcy, GSH, and H2S from each other, but also sequentially sensing Cys/Hcy/GSH and H2S using a multi-channel fluorescence mode for the first time...
September 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28966686/sevoflurane-may-be-more-beneficial-than-propofol-in-patients-receiving-endoscopic-variceal-ligation-and-endoscopic-variceal-sclerotherapy-a-randomized-double-blind-study
#10
Linghua Tang, Huimin Liu, Yang Wu, Mei Li, Wei Li, Meng Jiang, Jiabao Hou, Ying Jiang, Zhongyuan Xia, Qingtao Meng
The aim of the present study was to evaluate the safety and efficacy of various general anesthesia regimens during endoscopic variceal ligation (EVL) and endoscopic variceal sclerotherapy (EVS). A total of 123 patients with American Society of Anesthesiologists physical status III and IV, aged 40-70 years, undergoing general anesthesia for EVL and EVS were randomly divided into two groups: Sevoflurane anesthesia (group S; n=60) and propofol anesthesia (group P; n=60). Vital signs, particularly heart rate (HR) and mean arterial pressure (MAP), were monitored...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28961480/transient-noe-enhancement-in-solid-state-mas-nmr-of-mobile-systems
#11
Jiangyu Cui, Jun Li, Xinhua Peng, Riqiang Fu
It has been known that the heteronuclear cross-relaxation affects the dilute S spin magnetization along the longitudinal direction, causing an overshoot phenomenon for those mobile systems in spin-lattice relaxation rate measurements. Here, we analyze the Solomon equations for an I-S system and derive the transient cross relaxation effect as to when an overshoot phenomenon would take place and what the maximum enhancement could be at the time of the overshoot. In order to utilize such a transient nuclear Overhauser effect (NOE), we first time apply it to dynamic solid samples by inverting the (1)H magnetization prior to the excitation of the S spin...
September 19, 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28955051/early-detection-of-pulmonary-exacerbations-in-children-with-cystic-fibrosis-by-electronic-home-monitoring-of-symptoms-and-lung-function
#12
Marieke van Horck, Bjorn Winkens, Geertjan Wesseling, Dillys van Vliet, Kim van de Kant, Sanne Vaassen, Karin de Winter-de Groot, Ilja de Vreede, Quirijn Jöbsis, Edward Dompeling
Pulmonary exacerbations (PEx) in Cystic Fibrosis (CF) are associated with an increased morbidity and even mortality. We investigated whether early detection of PEx in children with CF is possible by electronic home monitoring of symptoms and lung function. During this one-year prospective multi-centre study, 49 children with CF were asked to use a home monitor three times a week. Measurements consisted of a respiratory symptom questionnaire and assessment of Forced Expiratory Volume in one second (FEV1). Linear mixed-effects and multiple logistic regression analyses were used...
September 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28914229/clinical-effectiveness-and-cost-effectiveness-of-beta-interferon-and-glatiramer-acetate-for-treating-multiple-sclerosis-systematic-review-and-economic-evaluation
#13
G J Melendez-Torres, Peter Auguste, Xavier Armoiry, Hendramoorthy Maheswaran, Rachel Court, Jason Madan, Alan Kan, Stephanie Lin, Carl Counsell, Jacoby Patterson, Jeremy Rodrigues, Olga Ciccarelli, Hannah Fraser, Aileen Clarke
BACKGROUND: At the time of publication of the most recent National Institute for Health and Care Excellence (NICE) guidance [technology appraisal (TA) 32] in 2002 on beta-interferon (IFN-β) and glatiramer acetate (GA) for multiple sclerosis, there was insufficient evidence of their clinical effectiveness and cost-effectiveness. OBJECTIVES: To undertake (1) systematic reviews of the clinical effectiveness and cost-effectiveness of IFN-β and GA in relapsing-remitting multiple sclerosis (RRMS), secondary progressive multiple sclerosis (SPMS) and clinically isolated syndrome (CIS) compared with best supportive care (BSC) and each other, investigating annualised relapse rate (ARR) and time to disability progression confirmed at 3 months and 6 months and (2) cost-effectiveness assessments of disease-modifying therapies (DMTs) for CIS and RRMS compared with BSC and each other...
September 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28910655/self-esteem-recognition-based-on-gait-pattern-using-kinect
#14
Bingli Sun, Zhan Zhang, Xingyun Liu, Bin Hu, Tingshao Zhu
BACKGROUND: Self-esteem is an important aspect of individual's mental health. When subjects are not able to complete self-report questionnaire, behavioral assessment will be a good supplement. In this paper, we propose to use gait data collected by Kinect as an indicator to recognize self-esteem. METHODS: 178 graduate students without disabilities participate in our study. Firstly, all participants complete the 10-item Rosenberg Self-Esteem Scale (RSS) to acquire self-esteem score...
October 2017: Gait & Posture
https://www.readbyqxmd.com/read/28904966/the-effect-of-oral-dexmedetomidine-premedication-on-preoperative-cooperation-and-emergence-delirium-in-children-undergoing-dental-procedures
#15
Sultan Keles, Ozlem Kocaturk
INTRODUCTION: The aim of this study was to detect the effect of 1 μg/kg of oral dexmedetomidine (DEX) as premedication among children undergoing dental procedures. MATERIALS AND METHODS: The study involved 100 children between 2 and 6 years of age, ASA I, who underwent full-mouth dental rehabilitation. The DEX group (n = 50) received 1 μg/kg DEX in apple juice, and the control group (n = 50) received only apple juice. The patients' scores on the Ramsay Sedation Scale (RSS), parental separation anxiety scale, mask acceptance scale, and pediatric anesthesia emergence delirium scale (PAEDS) and hemodynamic parameters were recorded...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28902107/reliability-of-the-maximal-resisted-sprint-load-test-and-relationships-with-performance-measures-and-anthropometric-profile-in-female-field-sport-athletes
#16
George Petrakos, Nicola C Tynan, Adam M Vallely-Farrell, Cillian Kiely, Abdelhak Boudhar, Brendan Egan
Resisted sled sprint (RSS) training is an effective modality for the improvement of linear sprint speed. Previous methods of RSS load prescription e.g. an absolute load or as a percentage of body mass (%BM), do not account for inter-individual differences in strength, power or speed characteristics, although the 'maximum resisted sled load' (MRSL) method of RSS load prescription may provide a solution. MRSL is defined as the final RSS load before an athlete can no longer accelerate between two phases (10-15 m and 15-20 m) of a 20 m linear sprint...
September 6, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28898988/comparison-of-oncotype-dx-with-modified-magee-equation-recurrence-scores-in-low-grade-invasive-carcinoma-of-breast
#17
COMPARATIVE STUDY
Yanjun Hou, Debra L Zynger, Xiaoxian Li, Zaibo Li
Objectives: Several specific histologic types of invasive carcinoma of breast, including invasive tubular carcinoma (ITC), invasive mucinous carcinoma (IMC), and classical invasive lobular carcinoma (CILC), are considered low-grade carcinomas with favorable outcomes. We aimed to investigate the utility of Oncotype DX test in these tumors by comparing its recurrence score (RS) with the modified Magee equation RS. Methods: Oncotype DX RSs were collected and modified Magee equation RSs were calculated in 163 low-grade invasive breast carcinomas, including 105 CILCs, 41 ITCs, and 17 IMCs...
August 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28893016/comparison-of-intubating-conditions-using-fentanyl-plus-propofol-versus-fentanyl-plus-midazolam-during-fiberoptic-laryngoscopy
#18
Parmod Kumar, Tripat Kaur, Gurpreet Kaur Atwal, Jatinderpaul Singh Bhupal, Ajay Kumar Basra
INTRODUCTION: Awake nasal or oral flexible fiberoptic intubation is the airway management technique of choice in known or anticipated difficult airway, unstable cervical fracture, limited mouth opening (as in temporomandibular joint disease), mandibular-maxillary fixation and severe facial burns. Both optimal intubating condition and patient comfort are important for fiberoptic intubation. Optimal intubating conditions provided by an ideal sedation regimen would ensure haemodynamic stability, patient comfort, attenuation of airway reflexes and amnesia...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28878428/elimination-of-guinea-worm-disease-in-ethiopia-current-status-of-the-disease-s-eradication-strategies-and-challenges-to-the-end-game
#19
Habtamu Bedimo Beyene, Abyot Bekele, Amanu Shifara, Yehenew A Ebstie, Zelalem Desalegn, Zeyede Kebede, Abate Mulugeta, Kebede Deribe, Zerihun Tadesse, Tamrat Abebe, Biruck Kebede, Getaneh Abrha, Daddi Jima
Dracunculiasis, also named Guinea Worm Disease (GWD), is one of the Neglected Tropical Diseases (NTDs) caused by a parasitic nematode known as Dracunculus medinensis and has been known since antiquity as 'fiery serpent' from Israelites. It is transmitted to humans via drinking contaminated water containing infective copepods. Given, its feasibility for eradication, the Guinea Worm Eradication Program (GWEP) was launched in 1980 with the aim of eradicating the disease. Since its inception, GWEP has made an extraordinary progress in interrupting transmission...
2017: Ethiopian Medical Journal
https://www.readbyqxmd.com/read/28877983/general-and-specific-promotions-of-flagellar-assembly-by-a-flagellar-nucleoside-diphosphate-kinase
#20
Xiaoyan Zhu, Emiliya Poghosyan, Radhika Gopal, Yi Liu, Kristine S Ciruelas, Yousif Maizy, Dennis R Diener, Stephen M King, Takashi Ishikawa, Pinfen Yang
Nucleoside diphosphate kinases (NDKs) play a central role in diverse cellular processes using the canonical NDK activity or alternative mechanisms that remain poorly defined. Our study of dimeric NDK5 in a flagellar motility control complex, the radial spoke (RS), has revealed new modalities. The flagella in Chlamydomonas ndk5 mutant were paralyzed, albeit only deficient in three RS subunits. RS morphology appeared severely changed in averaged cryo-electron tomograms, suggesting that NDK5 is crucial for the intact spokehead formation as well as RS structural stability...
September 6, 2017: Molecular Biology of the Cell
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