keyword
MENU ▼
Read by QxMD icon Read
search

Steroid addiction

keyword
https://www.readbyqxmd.com/read/29107956/estradiol-increases-the-sensitivity-of-ventral-tegmental-area-dopamine-neurons-to-dopamine-and-ethanol
#1
Bertha J Vandegrift, Chang You, Rosalba Satta, Mark S Brodie, Amy W Lasek
Gender differences in psychiatric disorders such as addiction may be modulated by the steroid hormone estrogen. For instance, 17β-estradiol (E2), the predominant form of circulating estrogen in pre-menopausal females, increases ethanol consumption, suggesting that E2 may affect the rewarding properties of ethanol and thus the development of alcohol use disorder in females. The ventral tegmental area (VTA) is critically involved in the rewarding and reinforcing effects of ethanol. In order to determine the role of E2 in VTA physiology, gonadally intact female mice were sacrificed during diestrus II (high E2) or estrus (low E2) for electrophysiology recordings...
2017: PloS One
https://www.readbyqxmd.com/read/28727662/paraphilic-thoughts-behaviors-and-sex-addiction-in-a-sample-of-persons-who-use-drugs-a-cross-sectional-study
#2
Jales Clemente, Sandra Cristina Pillon, Jair de Jesus Mari, Claudio Jeronimo da Silva, Paulo Roberto Henrique Santana, Alessandra Diehl
OBJECTIVE: The aim of this study was to evaluate the prevalence of paraphilic thoughts/behaviors (including paraphilic disorders) with and without sexual addiction and sexual-related conditions in a sample of substance disorder patients. METHODS: This was a cross-sectional study of substance-dependent individuals who sought outpatient treatment in São Paulo, Brazil. Data included sociodemographic information, drug of choice, responses to questions about sexual behavior, and to the following standardized questionnaires: (a) Sexual Addiction Screening Test, and (b) Childhood Trauma Questionnaire...
September 2017: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/28662295/%C3%AE-9-containing-nicotinic-acetylcholine-receptors-and-the-modulation-of-pain
#3
REVIEW
Arik J Hone, Denis Servent, J Michael McIntosh
Neuropathic pain is a complex and debilitating syndrome for which there are few effective pharmacological treatments. Opioid-based medications are initially effective for acute pain but tolerance to their analgesic effects quickly develops and long-term use often leads to physical dependence and addiction. Furthermore, neuropathic pain is generally resistant to non-steroidal anti-inflammatory drugs. Other classes of medications including antidepressants, antiepileptics, and voltage-gated calcium channel (VGCC) inhibitors are only partially effective in most patients, may be associated with significant side effects, and have few disease modifying effects on the underlying pathology...
June 29, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28499916/effects-of-neonatal-and-adolescent-neuroactive-steroid-manipulation-on-locomotor-activity-induced-by-ethanol-in-male-wistar-rats
#4
Iris Bartolomé, Anna Llidó, Sònia Darbra, Marc Pallarès
Neonatal neuroactive steroids levels are crucial for brain development. Alterations of neonatal neuroactive steroids levels induce anxiolytic-like effects and improve exploration in novel environments in adulthood. These behavioural traits, i.e. sensation/novelty seeking, anxiety or impulsivity, are associated with vulnerability to drug use and abuse. Adolescence is also recognized as a particularly critical developmental phase to contribute to vulnerable phenotype. However, the influence of neuroactive steroids during development in the vulnerability to drug addiction has been poorly studied...
May 10, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28429885/intravenous-self-administration-of-benzydamine-a-non-steroidal-anti-inflammatory-drug-with-a-central-cannabinoidergic-mechanism-of-action
#5
Riccardo Avvisati, Maria Meringolo, Emiliana Stendardo, Elisa Malavasi, Silvia Marinelli, Aldo Badiani
Benzydamine (BZY) is a non-steroidal anti-inflammatory drug used for the topical treatment of inflammations of the oral and vaginal mucosae. Virtually nothing is known about the central pharmacological actions of BZY. Yet there are reports of voluntary systemic overdosage of BZY in drug addicts, resulting in a euphoric, hallucinatory state. In the present study, we investigated the reinforcing properties of BZY in a rat self-administration paradigm. We found that BZY has a powerful reinforcing effect and that this effect is greatly facilitated in animals that already had substance experience, having previously self-administered heroin and cocaine, indicating cross sensitization between BZY and other common drugs of abuse...
April 21, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28214737/identification-of-non-steroidal-anti-inflammatory-drug-use-disorder-a-case-report
#6
Margo E Godersky, Laura K Vercammen, Alicia S Ventura, Alexander Y Walley, Richard Saitz
Commonly used for analgesic and anti-inflammatory effects, non-steroidal anti-inflammatory drugs (NSAIDs) are among the most frequently used medications in the world. In spite of their prevalence, reports of NSAID misuse and NSAID use disorder are uncommon. This case report describes a research participant who met criteria for DSM-5 moderate substance use disorder based on her use of prescribed ibuprofen as assessed by the validated Mini International Neuropsychiatric Interview (MINI). This case demonstrates that the DSM-5 criteria within the MINI can be applied to diagnose an NSAID use disorder...
July 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28214679/estradiol-is-a-critical-regulator-of-food-reward-behavior
#7
Jennifer E Richard, Lorena López-Ferreras, Rozita H Anderberg, Kajsa Olandersson, Karolina P Skibicka
Food intake is reduced by estrogenic hormones, levels of which vary throughout life and fluctuate throughout the ovarian cycle in females. However, estrogens have also been shown to increase reward derived from drugs of abuse, where motivational properties of drugs and progression to addiction are potentiated by estrogens. Whether reward derived from food, and specifically motivational properties of food, are altered by estrogens remains unknown. Here we investigated the effect of the estrous cycle on food reward behavior and show estrous cycle dictated variability in food motivation, measured by progressive ratio operant conditioning, in female rats...
January 28, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27534827/efficacy-and-safety-of-radioiodine-therapy-for-mild-graves-ophthalmopathy-depending-on-cigarette-consumption-a-6%C3%A2-month-follow%C3%A2-up
#8
Agata Czarnywojtek, Krzesisława Komar-Rychlicka, Małgorzata Zgorzalewicz-Stachowiak, Nadia Sawicka-Gutaj, Kosma Woliński, Paweł Gut, Maria Płazinska, Barbara Torlińska, Ewa Florek, Joanna Waligórska-Stachura, Marek Ruchała
INTRODUCTION    Graves ophthalmopathy (GO) is an autoimmune disease associated with Graves disease. Its treatment is largely dependent on the severity and activity of ocular lesions. Particular attention should be given to radioiodine (RAI) therapy. Although its use is a valuable therapeutic option for hyperthyroidism, it may be followed by worsening of GO.  OBJECTIVES    The aim of the present study was to analyze how the severity of nicotine addiction affects the response to RAI treatment in patients with GO...
August 18, 2016: Polskie Archiwum Medycyny Wewnętrznej
https://www.readbyqxmd.com/read/27525430/vegetarian-diet-and-excessive-tea-consumption-a-dangerous-association
#9
Fabrizio Fiacco, Luca Barbato, Maria Giovanna Pecoraro, Paola Maggio
Rare metabolic diseases may sometimes arise acutely and endanger human life if not immediately recognized and treated. Marchiafava Bignami disease is an uncommon neurologic disorder described in alcohol abusers and characterized by an acute severe damage of brain white matter. Even more rarely, it has been reported in non-alcohol addicted patients, but never in vegetarian people. This is a case report of a young vegetarian woman, accustomed to drink high amounts of tea, who, three weeks after her first natural childbirth, developed serious motor and cognitive disturbances...
February 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/27378657/precise-and-accurate-assay-of-pregnenolone-and-five-other-neurosteroids-in-monkey-brain-tissue-by-lc-ms-ms
#10
Alain Y Dury, Yuyong Ke, Fernand Labrie
A series of steroids present in the brain have been named "neurosteroids" following the possibility of their role in the central nervous system impairments such as anxiety disorders, depression, premenstrual dysphoric disorder (PMDD), addiction, or even neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. Study of their potential role requires a sensitive and accurate assay of their concentration in the monkey brain, the closest model to the human. We have thus developed a robust, precise and accurate liquid chromatography-tandem mass spectrometry method for the assay of pregnenolone, pregnanolone, epipregnanolone, allopregnanolone, epiallopregnanolone, and androsterone in the cynomolgus monkey brain...
September 2016: Steroids
https://www.readbyqxmd.com/read/27156843/the-neurobiology-and-addiction-potential-of-anabolic-androgenic-steroids-and-the-effects-of-growth-hormone
#11
REVIEW
Alfhild Grönbladh, Erik Nylander, Mathias Hallberg
Anabolic androgenic steroids (AAS) are substances that mimic the hormone testosterone, and primarily act via the androgen receptor. In addition to their physiological effect on muscle tissue and growth, research from the last decade has shown that AAS have a pronounced impact on the central nervous system. A large number of studies have demonstrated that AAS affect the mesolimbic reward system in the brain. However, whether the direct effects of AAS on endorphins, dopamine, serotonin and GABA etc. and on the corresponding and related systems lead to dependence needs to be further elucidated...
September 2016: Brain Research Bulletin
https://www.readbyqxmd.com/read/27149135/knowledge-about-ultraviolet-radiation-hazards-and-tanning-behavior-of-cosmetology-and-medical-students
#12
Ewelina Bogumiła Zuba, Wojciech Francuzik, Przemysław Malicki, Agnieszka Osmola-Mańkowska, Dorota Jenerowicz
Dear Editor, Ultraviolet (UV) radiation is a well-known physical hazard responsible for photoaging, photoallergic, and phototoxic reactions as well as carcinogenesis, including life-threatening melanomas (1,2). Overexposure to both natural and artificial UV radiation is a public health concern. 30% of cancers diagnosed worldwide are skin cancers. Approximately three million non-melanoma skin cancers and 132 000 new cases of melanomas are diagnosed globally each year (3). Sunburns, especially in childhood, are a very important risk factor for melanomas...
April 2016: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/27142107/analgesic-prodrugs-for-combating-their-side-effects-rational-approach
#13
REVIEW
Ruchita, Sucheta, Sanju Nanda, Dharampal Pathak
BACKGROUND: Analgesics are the drugs which bring insensibility to pain without loosing consciousness. Treatment strategy is generally based on the type of pain. Most of the analgesics are associated with serious side effects, such as NSAIDS can cause severe GI disturbance and opioids can cause addiction. There are various ways to reduce their side effects The analgesic prodrug approach is one of the several strategies used to attain the required pharmacological response with a considerable decrease in side effects...
2017: Current Drug Delivery
https://www.readbyqxmd.com/read/27136260/factors-associated-with-changes-in-body-composition-shortly-after-orthotopic-liver-transplantation-the-potential-influence-of-immunosuppressive-agents
#14
COMPARATIVE STUDY
Ana Brito-Costa, Luís Pereira-da-Silva, Ana Luísa Papoila, Marta Alves, Élia Mateus, Fernando Nolasco, Eduardo Barroso
BACKGROUND: This study aimed to determine factors associated with body composition changes shortly after liver transplantation (LTx), including the influence of immunosuppressive agents. The combined resting energy expenditure (REE) and handgrip strength provided a valuable assessment in data interpretation of body composition. METHODS: This observational single-center study included a cohort of consecutive end-stage liver disease patients with indications for LTx over 2 years...
August 2016: Transplantation
https://www.readbyqxmd.com/read/27069021/sigma1-receptors-inhibit-store-operated-ca2-entry-by-attenuating-coupling-of-stim1-to-orai1
#15
Shyam Srivats, Dilshan Balasuriya, Mathias Pasche, Gerard Vistal, J Michael Edwardson, Colin W Taylor, Ruth D Murrell-Lagnado
Sigma1 receptors (σ1Rs) are expressed widely; they bind diverse ligands, including psychotropic drugs and steroids, regulate many ion channels, and are implicated in cancer and addiction. It is not known how σ1Rs exert such varied effects. We demonstrate that σ1Rs inhibit store-operated Ca(2+)entry (SOCE), a major Ca(2+)influx pathway, and reduce the Ca(2+)content of the intracellular stores. SOCE was inhibited by expression of σ1R or an agonist of σ1R and enhanced by loss of σ1R or an antagonist. Within the endoplasmic reticulum (ER), σ1R associated with STIM1, the ER Ca(2+)sensor that regulates SOCE...
April 11, 2016: Journal of Cell Biology
https://www.readbyqxmd.com/read/27029841/why-we-should-consider-sex-and-study-sex-differences-in-addiction-research
#16
Carla Sanchis-Segura, Jill B Becker
Among mammals, every cell has a biological sex, and the sex of an individual pervades its body and brain. In this review, we describe the processes through which mammals become phenotypically male or female by organizational and activational influences of genes and hormones throughout development. We emphasized that the molecular and cellular changes triggered by sex chromosomes and steroid hormones may generate sex differences in overt physiological functions and behavior, but they may alternatively promote end-point convergences between males and females...
September 2016: Addiction Biology
https://www.readbyqxmd.com/read/27001330/the-jewelry-addict-allergic-contact-dermatitis-from-repetitive-multiple-children-s-jewelry-exposures
#17
Nanette B Silverberg
A 9-year-old girl with atopic dermatitis developed persistent plaques on the lips, hands, and fingers that were unresponsive to topical steroids. Her mother reported that she was "addicted" to costume jewelry and developed rashes in reaction to a number of adornments, ranging from rubber bracelets to costume metal jewelry and belt buckles. A careful history of jewelry exposures was taken and patch testing was performed to identify allergenic sources. Patch testing revealed allergy to nickel, gold, and thiuram mix...
March 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/26873455/knowledge-and-perceptions-of-asthma-in-zambia-a-cross-sectional-survey
#18
Emilia Jumbe Marsden, Somwe Wa Somwe, Chishala Chabala, Joan B Soriano, Cesar Picado Vallès, Julio Anchochea
BACKGROUND: Zambia is currently experiencing an epidemiological transition, from communicable to non-communicable diseases. The annual rate of physician-diagnosed asthma is estimated at 3 %. However, the general public's knowledge of asthma symptoms and signs, and their perception of asthma remain unknown. A survey was conducted aiming to determine knowledge and perceptions of asthma among Zambians. METHODS: Adults and adolescents attending four clinics in the capital, Lusaka, were surveyed using a standardized questionnaire from July 2011 to March 2012...
February 12, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/26838582/histological-and-immunohistological-findings-using-anti-cortisol-antibody-in-atopic-dermatitis-with-topical-steroid-addiction
#19
Mototsugu Fukaya
INTRODUCTION: Though topical steroid addiction (TSA) in patients with atopic dermatitis (AD) has been recently discussed as a clinical problem, there are very few studies about its mechanism. The purpose of this study was to elucidate histological and immunohistological characteristics of TSA using anti-cortisol antibody. METHODS: Skin biopsy specimen from eight patients with AD was stained by anti-cortisol antibody (Biorbyt, orb79379). Subjects consisted of a child patient with a short history of topical corticosteroids (TCS) application, an adult patient with a long history of TCS application, and six adult patients who have experienced topical steroid withdrawal (TSW) and the rebound phenomenon...
March 2016: Dermatology and Therapy
https://www.readbyqxmd.com/read/26830291/morphine-inhibited-the-rat-neural-stem-cell-proliferation-rate-by-increasing-neuro-steroid-genesis
#20
Navid Feizy, Alireza Nourazarian, Reza Rahbarghazi, Hojjatollah Nozad Charoudeh, Nima Abdyazdani, Soheila Montazersaheb, Mohamadreza Narimani
Up to present, a large number of reports unveiled exacerbating effects of both long- and short-term administration of morphine, as a potent analgesic agent, on opium-addicted individuals and a plethora of cell kinetics, although contradictory effect of morphine on different cells have been introduced until yet. To address the potent modulatory effect of morphine on neural multipotent precursors with emphasis on endogenous sex-related neurosteroids biosynthesis, we primed the rat neural stem cells isolated from embryonic rat telencephalon to various concentrations of morphine including 10, 20, 50 and 100 µM alone or in combination with naloxone (100 µM) over period of 72 h...
June 2016: Neurochemical Research
keyword
keyword
59572
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"