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https://www.readbyqxmd.com/read/29141241/mmp-9-and-its-regulators-timp-1-and-emmprin-in-patients-with-acute-st-elevation-myocardial-infarction-a-nordistemi-substudy
#1
Trine Baur Opstad, Ingebjørg Seljeflot, Ellen Bøhmer, Harald Arnesen, Sigrun Halvorsen
OBJECTIVES: The extracellular matrix is involved in wound repair after acute myocardial infarction (AMI). We investigated whether matrix metalloproteinase (MMP)-9, tissue inhibitor of metalloproteinases (TIMP)-1, and the MMP inducer (EMMPRIN) are associated with infarct size, left ventricular function, and clinical outcome in ST-elevation-MI (STEMI). METHODS: In 243 STEMI patients, circulating EMMPRIN, MMP-9, and TIMP-1 were analyzed 3 days and 3 months post-AMI...
November 16, 2017: Cardiology
https://www.readbyqxmd.com/read/29141145/homochiral-versus-heterochiral-trifluoromethylated-pseudoproline-containing-dipeptides-a-powerful-tool-to-switch-the-prolyl-amide-bond-conformation
#2
Grégory Chaume, Julien Simon, Nathalie Lensen, Julien Pytkowicz, Thierry Brigaud, Emeric Miclet
The design of constrained peptides is of prime importance in the development of bioactive compounds and for applications in supramolecular chemistry. Due to its nature, the peptide bond undergoes a spontaneous cis-trans isomerism and the cis isomers are much more difficult to stabilize than the trans forms. By using oxazolidine-based pseudoprolines (ΨPro) substituted by a trifluoromethyl group, we show that the cis peptide bond can be readily switched from 0% to 100% in Xaa-ΨPro dipeptides. Our results prove that changing the configuration of the Cα in Xaa or in ΨPro is sufficient to invert the cis:trans populations while changing the nature of the Xaa side chain finely tuned the conformers ratio...
November 15, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29141140/n-heterocyclic-carbene-self-assembled-monolayers-on-gold-as-surface-plasmon-resonance-biosensors
#3
Zhijun Li, Kim A Munro, Iraklii I Ebralidze, Mina R Narouz, J Daniel Padmos, Hongxia Hao, Cathleen M Crudden, J Hugh Horton
Surface plasmon resonance (SPR)-based biosensing is a powerful tool to study the recognition processes between biomole-cules in real-time without need for labels. The use of thiol chemistry is a critical component in surface functionalization of various SPR biosensor surfaces on gold. However, its use is hampered by the high propensity for oxidation of the gold-thiol linkage even in ambient atmosphere, resulting in a short lifetime of SPR sensor chips unless strict precautions are taken. Herein, we describe an approach to overcome this limitation by employing highly robust self-assembled monolayers (SAMs) of alkylated N-heterocyclic carbenes (NHCs) on gold...
November 15, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29141114/ph-ultrasound-dual-responsive-gas-generator-for-ultrasound-imaging-guided-therapeutic-inertial-cavitation-and-sonodynamic-therapy
#4
Qianhua Feng, Wanxia Zhang, Xuemei Yang, Yuzhen Li, Yongwei Hao, Hongling Zhang, Lin Hou, Zhenzhong Zhang
Herein, a pH/ultrasound dual-responsive gas generator is reported, which is based on mesoporous calcium carbonate (MCC) nanoparticles by loading sonosensitizer (hematoporphyrin monomethyl ether (HMME)) and modifying surface hyaluronic acid (HA). After pinpointing tumor regions with prominent targeting efficiency, HMME/MCC-HA decomposes instantaneously under the cotriggering of tumoral inherent acidic condition and ultrasound (US) irradiation, concurrently accompanying with CO2 generation and HMME release with spatial/temporal resolution...
November 15, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29141080/the-associations-of-lens-power-with-age-and-axial-length-in-healthy-chinese-children-and-adolescents-aged-6-to-18-years
#5
Shuyu Xiong, Bo Zhang, Yuan Hong, Xiangui He, Jianfeng Zhu, Haidong Zou, Xun Xu
Purpose: To investigate the relationship between lens power and age as well as the relationship between lens power and axial length (AL) in Chinese children and adolescents. Methods: The participants underwent a comprehensive ophthalmic examination that included AL, cycloplegic refraction, and Pentacam measurements. The crystalline lens power was calculated using Bennett's formula and then compared among the children of different age groups, refractive statuses, and AL categories...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29141050/differential-immunomodulation-in-human-monocytes-versus-macrophages-by-filarial-cystatin
#6
Gopinath Venugopal, Marion Mueller, Susanne Hartmann, Svenja Steinfelder
Parasitic nematodes have evolved powerful immunomodulatory molecules to enable their survival in immunocompetent hosts by subverting immune responses and minimizing pathological processes. One filarial molecule known to counteract host immune responses by inducing IL-10 and regulatory macrophages in mice is filarial cystatin. During a patent filarial infection monocytes encounter microfilariae in the blood, an event that occurs in asymptomatically infected filariasis patients that are immunologically hyporeactive...
2017: PloS One
https://www.readbyqxmd.com/read/29141034/structure-of-the-human-chromosome-interaction-network
#7
Sergio Sarnataro, Andrea M Chiariello, Andrea Esposito, Antonella Prisco, Mario Nicodemi
New Hi-C technologies have revealed that chromosomes have a complex network of spatial contacts in the cell nucleus of higher organisms, whose organisation is only partially understood. Here, we investigate the structure of such a network in human GM12878 cells, to derive a large scale picture of nuclear architecture. We find that the intensity of intra-chromosomal interactions is power-law distributed. Inter-chromosomal interactions are two orders of magnitude weaker and exponentially distributed, yet they are not randomly arranged along the genomic sequence...
2017: PloS One
https://www.readbyqxmd.com/read/29140998/using-whole-genome-sequencing-to-study-american-foulbrood-epidemiology-in-honeybees
#8
Joakim Ågren, Marc Oliver Schäfer, Eva Forsgren
American foulbrood (AFB), caused by Paenibacillus larvae, is a devastating disease in honeybees. In most countries, the disease is controlled through compulsory burning of symptomatic colonies causing major economic losses in apiculture. The pathogen is endemic to honeybees world-wide and is readily transmitted via the movement of hive equipment or bees. Molecular epidemiology of AFB currently largely relies on placing isolates in one of four ERIC-genotypes. However, a more powerful alternative is multi-locus sequence typing (MLST) using whole-genome sequencing (WGS), which allows for high-resolution studies of disease outbreaks...
2017: PloS One
https://www.readbyqxmd.com/read/29140977/low-cost-and-open-source-multi-fluorescence-imaging-system-for-teaching-and-research-in-biology-and-bioengineering
#9
Isaac Nuñez, Tamara Matute, Roberto Herrera, Juan Keymer, Timothy Marzullo, Timothy Rudge, Fernán Federici
The advent of easy-to-use open source microcontrollers, off-the-shelf electronics and customizable manufacturing technologies has facilitated the development of inexpensive scientific devices and laboratory equipment. In this study, we describe an imaging system that integrates low-cost and open-source hardware, software and genetic resources. The multi-fluorescence imaging system consists of readily available 470 nm LEDs, a Raspberry Pi camera and a set of filters made with low cost acrylics. This device allows imaging in scales ranging from single colonies to entire plates...
2017: PloS One
https://www.readbyqxmd.com/read/29140919/collaboration-and-teamwork-in-the-health-professions-rethinking-the-role-of-conflict
#10
Quentin Eichbaum
Whereas the business professions have long recognized that conflict can be a source of learning and innovation, the health professions still tend to view conflict negatively as being disruptive, inefficient, and unprofessional. As a consequence, the health professions tend to avoid conflict or resolve it quickly. This neglect to appreciate conflict's positive attributes appears to be driven in part by (1) individuals' fears about being negatively perceived and the potential negative consequences in an organization of being implicated in conflict, (2) constrained views and approaches to professionalism and to evaluation and assessment, and (3) lingering autocracies and hierarchies of power that view conflict as a disruptive threat...
November 14, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29140914/sequencing-effects-of-neuromuscular-training-on-physical-fitness-in-youth-elite-tennis-players
#11
Jaime Fernandez-Fernandez, Urs Granacher, David Sanz-Rivas, Jose Manuel Sarabia Marín, Jose Luis Hernandez-Davo, Manuel Moya
Fernandez-Fernandez, J, Granacher, U, Sanz-Rivas, D, Sarabia Marín, JM, Hernandez-Davo, JL, and Moya, M. Sequencing effects of neuromuscular training on physical fitness in youth elite tennis players. J Strength Cond Res XX(X): 000-000, 2017-The aim of this study was to analyze the effects of a 5-week neuromuscular training (NMT) implemented before or after a tennis session in prepubertal players on selected components of physical fitness. Sixteen elite and well-trained tennis players with a mean age of 12...
November 14, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29140913/sex-differences-in-aerobic-fitness-in-top-class-soccer-referees
#12
Carlo Castagna, Mario Bizzini, Stefano DʼOttavio, Susana C Araújo Póvoas
Castagna, C, Bizzini, M, D'Ottavio, S, and Araújo Póvoas, SC. Gender differences in aerobic fitness in top-class soccer referees. J Strength Cond Res XX(X): 000-000, 2017-The aim of this study was to assess the aerobic-fitness differences between male and female top-class soccer field referees (FRs). This with the purpose to provide cutoff values useful for training prescription in female FRs. Forty female top-class FRs (age 34.18 ± 3.50 years and 5 ± 3.9 years international refereeing experience) and 52 male FRs (age 38...
November 14, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29140909/the-effects-of-load-on-peak-power-output-fatigue-during-the-bench-throw
#13
David Boffey, Bulent Sokmen, Kurt Sollanek, Wanda Boda, Steven Winter
The ability to create power is an important variable for athletic success. No study to date has compared peak power output (PPO) fatigue across multiple sets and with different loads with the bench throw. This study aimed to begin the process of establishing empirical upper body power training guidelines for moderately strong athletes by determining how load (30%, 45%, 60% 1RM) affects PPO (Watts) dropoff during 3 sets of 10 repetitions of the bench throw. 10 resistance-trained male volunteers ((mean ± SD): age 20...
November 14, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29140831/relative-efficacies-of-hboc-201-and-polyheme-to-increase-oxygen-transport-compared-to-blood-and-crystalloids-2017-military-supplement
#14
Gregory P Dubé, Arkadiy N Pitman, Colin F Mackenzie
BACKGROUND: Because total hemoglobin in circulation ([THb]) is an established predictor of clinical outcomes in anemic individuals, the relative efficacies of resuscitation fluids to increase [THb] can be used to design better hemoglobin-based oxygen carrier (HBOC) clinical trials. METHODS: Expected efficacies of HBOC-201 (13 g Hb/dL) and packed RBCs (pRBCs, 24 g Hb/dL) to increase [THb] were calculated and interpreted in the context of SAEs in the HEM-0115 phase III clinical trial...
November 14, 2017: Shock
https://www.readbyqxmd.com/read/29140754/comparing-diversity-of-fungi-from-living-leaves-using-culturing-and-high-throughput-environmental-sequencing
#15
Peter R Johnston, Duckchul Park, Rob D Smissen
High-throughput sequencing technologies using amplicon approaches have changed the way that studies investigating fungal distribution are undertaken. These powerful and time-efficient technologies have the potential for the first time to accurately map fungal distributions across landscapes or changes in diversity across ecological or biological gradients of interest. There is no requirement for a fungus to form a fruiting body to be detected, and both culturable and nonculturable organisms can be detected...
October 6, 2017: Mycologia
https://www.readbyqxmd.com/read/29140728/sample-based-models-of-protein-energy-landscapes-and-slow-structural-rearrangements
#16
Tatiana Maximova, Zijing Zhang, Daniel B Carr, Erion Plaku, Amarda Shehu
Proteins often undergo slow structural rearrangements that involve several angstroms and surpass the nanosecond timescale. These spatiotemporal scales challenge physics-based simulations and open the way to sample-based models of structural dynamics. This article improves an understanding of current capabilities and limitations of sample-based models of dynamics. Borrowing from widely used concepts in evolutionary computation, this article introduces two conflicting aspects of sampling capability and quantifies them via statistical (and graphical) analysis tools...
November 15, 2017: Journal of Computational Biology: a Journal of Computational Molecular Cell Biology
https://www.readbyqxmd.com/read/29140727/population-genomics-of-herbicide-resistance-adaptation-via-evolutionary-rescue
#17
Julia M Kreiner, John R Stinchcombe, Stephen I Wright
The evolution of herbicide resistance in weed populations is a highly replicated example of adaptation surmounting the race against extinction, but the factors determining its rate and nature remain poorly understood. Here, we explore theory and empirical evidence for the importance of population genetic parameters-including effective population size, dominance, mutational target size, and gene flow-in influencing the probability and mode of herbicide resistance adaptation and its variation across species. We compiled data on the number of resistance mutations across populations for 79 herbicide-resistant species...
November 15, 2017: Annual Review of Plant Biology
https://www.readbyqxmd.com/read/29140710/transition-metal-free-intermolecular-%C3%AE-arylation-of-ketones-via-enolonium-species
#18
Shimon Maksymenko, Keshaba N Parida, Gulab K Pathe, Atul A More, Yuriy B Lipisa, Alex M Szpilman
Herein it is shown, for the first time, that enolonium species are powerful electrophiles capable of reacting with aromatic compounds in an intermolecular manner to afford α-arylated ketones. The reaction is compatible with a variety of functional groups, is of wide scope with respect to aromatic compounds and ketone, and even works for polymerization-prone substrates such as substituted pyrroles, thiophenes, and furans. Only 1.6 to 5 equiv of the commodity aromatic substrates is needed.
November 15, 2017: Organic Letters
https://www.readbyqxmd.com/read/29140701/the-hydrophobe-challenge-a-joint-experimental-and-computational-study-on-the-host-guest-binding-of-hydrocarbons-to-cucurbiturils-allowing-explicit-evaluation-of-guest-hydration-free-energy-contributions
#19
Khaleel I Assaf, Mara Florea, Jens Antony, Niel M Henriksen, Jian Yin, Andreas Hansen, Zheng-Wang Qu, Rebecca Sure, Dieter Klapstein, Michael K Gilson, Stefan Grimme, Werner M Nau
The host-guest complexation of hydrocarbons (22 guest molecules) with cucurbit[7]uril was investigated in aqueous solution by using the indicator displacement strategy. The binding constants (10(3)-10(9) M(-1)) increased with guest size, pointing to the hydrophobic effect and dispersion interactions as driving forces. The measured affinities provide unique benchmark data for the binding of neutral guest molecules. Consequently, a computational blind challenge, the HYDROPHOBE challenge, was conducted in order to allow a comparison with state-of-the-art computational methods for predicting host-guest affinity constants...
November 15, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29140653/outsource-power-import-safety-challenges-and-opportunities-of-the-u-s-china-food-safety-regulatory-cooperation
#20
Ching-Fu Lin
The United States has a high stake in China’s serious food safety problem, as food products of Chinese origin have dominated the U.S. food market in numerous areas and continue to grow. The conclusion of the U.S.-China Food Safety Agreement (“the Agreement”) has allowed FDA to strengthen regulatory cooperation with its Chinese counterpart in various aspects. The Agreement also paves the way for the implementation of the new regulatory tools incorporated in FSMA, especially in the cross-border context...
2017: Food and Drug Law Journal
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