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https://www.readbyqxmd.com/read/29330739/patterns-and-outcomes-of-prescribing-venous-thromboembolism-prophylaxis-in-hospitalized-older-adults-a-retrospective-cohort-study
#1
Mark Goldin, Jessica Cohen, Alex Makhnevich, Colm Mulvany, Meredith Akerman, Liron Sinvani
Venous thromboembolism (VTE) is a major cause of morbidity and mortality in the United States. Hospitalized, medically ill older adults have increased risk; despite guidelines, data suggest suboptimal pharmacologic prophylaxis rates. Factors influencing provider prescribing non-compliance are unclear. We aimed to describe VTE prophylaxis practices and identify risk factors for, and outcomes of, prescribing non-compliance. A retrospective study was conducted of hospitalized adults aged ≥ 75 years, admitted to the medicine service of a large academic tertiary center from May 1, 2014 to June 30, 2015...
January 12, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29329662/a-summation-analysis-of-compliance-and-complications-of-compression-hosiery-for-patients-with-chronic-venous-disease-or-post-thrombotic-syndrome
#2
REVIEW
Hadyn K N Kankam, Chung S Lim, Francesca Fiorentino, Alun H Davies, Manj S Gohel
OBJECTIVES: Compression stockings are commonly prescribed for patients with a range of venous disorders, but are difficult to don and uncomfortable to wear. This study aimed to investigate compliance and complications of compression stockings in patients with chronic venous disease (CVD) and post-thrombotic syndrome (PTS). METHODS: A literature search of the following databases was carried out: MEDLINE (via PubMed), EMBASE (via OvidSP, 1974 to present), and CINAHL (via EBSCOhost)...
January 9, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29328762/patients-experiences-with-at-home-preoperative-skin-disinfection-before-elective-hip-replacement-surgery
#3
Maria Qvistgaard, Sofia Almerud Österberg, Kristiina Heikkilä, Ann-Britt Thorén, Jenny Lovebo
The aim of the study was to describe patients' experiences with preoperative skin disinfection carried out in their home before elective hip replacement surgery with the aim of lowering the microbial burden and avoiding surgical site infections. The literature was reviewed for relevant studies. Optimal preparations before surgery depend on patients being able to assimilate preoperative information and instructions. The study was based on 14 interviews with patients who had undergone elective hip replacement surgery...
July 2017: Journal of Perioperative Practice
https://www.readbyqxmd.com/read/29321273/how-tobacco-companies-in-the-uk-prepared-for-and-responded-to-standardised-packaging-of-cigarettes-and-rolling-tobacco
#4
Crawford Moodie, Kathryn Angus, Danielle Mitchell, Nathan Critchlow
INTRODUCTION: As a result of the Standardised Packaging of Tobacco Products Regulations and Tobacco Products Directive, all packs of cigarettes (factory-made and hand-rolled) in the UK must be drab brown, display pictorial warnings on the principal display areas and contain no less than 20 cigarettes or 30 g of tobacco. The legislation was phased in between May 2016 and May 2017. Our objective was to monitor pack, brand and product changes preimplementation and postimplementation. METHODS: Our surveillance of the cigarette market involved a review of the trade press, a monthly monitor of online supermarkets and regular visits to stores, from May 2015 to June 2017...
January 10, 2018: Tobacco Control
https://www.readbyqxmd.com/read/29321046/application-of-causal-inference-methods-in-the-analyses-of-randomised-controlled-trials-a-systematic-review
#5
REVIEW
Ruth E Farmer, Daphne Kounali, A Sarah Walker, Jelena Savović, Alison Richards, Margaret T May, Deborah Ford
BACKGROUND: Applications of causal inference methods to randomised controlled trial (RCT) data have usually focused on adjusting for compliance with the randomised intervention rather than on using RCT data to address other, non-randomised questions. In this paper we review use of causal inference methods to assess the impact of aspects of patient management other than the randomised intervention in RCTs. METHODS: We identified papers that used causal inference methodology in RCT data from Medline, Premedline, Embase, Cochrane Library, and Web of Science from 1986 to September 2014, using a forward citation search of five seminal papers, and a keyword search...
January 10, 2018: Trials
https://www.readbyqxmd.com/read/29314552/australian-multicentre-study-of-current-real-world-prophylaxis-practice-in-severe-and-moderate-haemophilia-a-and-b
#6
J A Mason, S Parikh, H Tran, J Rowell, S McRae
INTRODUCTION: With the emergence of novel treatment products for haemophilia and an increasing focus on the benefits of pharmacokinetic driven individualized prophylaxis, robust national data with regard to current patterns of factor consumption and adherence are required. AIM: To characterize current Australian practice with regard to use of prophylactic clotting factor infusions in patients with moderate or severe haemophilia A (HA) and haemophilia B (HB). METHODS: This was a retrospective, non-interventional study utilizing Australian Bleeding Disorder Registry (ABDR) data collected over a 12 month period...
January 3, 2018: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/29311137/late-occurring-and-long-circulating-metabolites-of-gabaa%C3%AE-2-3-receptor-modulator-azd7325-involving-metabolic-cyclization-and-aromatization-relevance-to-mist-analysis-and-application-for-patient-compliance
#7
Chungang Gu, Markus Artelsmair, Charles S Elmore, Richard J Lewis, Patty Davis, James E Hall, Bruce T Dembofsky, Greg Christoph, Mark A Smith, Marc Chapdelaine, Maria Sunzel
AZD7325 [4-amino-8-(2-fluoro-6-methoxyphenyl)-N-propylcinnoline-3-carboxamide] is a selective GABAAα2,3 receptor modulator intended for the treatment of anxiety disorders through oral administration. An interesting metabolic cyclization and aromatization pathway led to the tricyclic core of M9, i.e. 2-ethyl-7-(2-fluoro-6-methoxyphenyl)pyrimido[5,4-c]cinnolin-4(3H)-one. Further oxidative metabolism generated M10 via O-demethylation and M42 via hydroxylation. An authentic standard of M9 was synthesized to confirm the novel structure of M9 and that of M10 and M42 by liver microsomal incubation of the M9 standard...
January 8, 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/29304792/aberrant-use-and-poor-quality-of-trypanocides-a-risk-for-drug-resistance-in-south-western-ethiopia
#8
T Tekle, G Terefe, T Cherenet, H Ashenafi, K G Akoda, A Teko-Agbo, J Van Den Abbeele, G Gari, P-H Clausen, A Hoppenheit, R C Mattioli, R Peter, T Marcotty, G Cecchi, V Delespaux
BACKGROUND: Trypanocidal drugs have been used to control African animal trypanosomosis for several decades. In Ethiopia, these drugs are available from both authorized (legal) and unauthorized (illegal) sources but documentation on utilization practices and quality of circulating products is scanty. This study looked at the practices of trypanocidal drug utilization by farmers and the integrity of active ingredient in trypanocides sold in Gurage zone, south western Ethiopia. The surveys were based on a structured questionnaire and drug quality determination of commonly used brands originating from European and Asian companies and sold at both authorized and unauthorized markets...
January 5, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29299849/lipid-management-in-chronic-kidney-disease-systematic-review-of-pcsk9-targeting
#9
REVIEW
BinBin Zheng-Lin, Alberto Ortiz
Cardiovascular disease is the leading cause of death in patients with chronic kidney disease (CKD) and CKD is considered a coronary artery disease risk equivalent. So far, statins have been the mainstay of primary and secondary prevention of cardiovascular disease in the general population. However, their benefit on outcomes is limited and controversial in CKD patients and new therapeutic approaches to reduce cardiovascular risk are needed. Monoclonal antibodies targeting proprotein convertase subtilisin/kexin 9 (PCSK9) reduce low-density lipoprotein cholesterol (LDL-C) and lipoprotein(a) in high-risk populations and cardiovascular events in secondary prevention...
January 3, 2018: Drugs
https://www.readbyqxmd.com/read/29288095/microparticles-microcapsules-and-microspheres-a-review-of-recent-developments-and-prospects-for-oral-delivery-of-insulin
#10
REVIEW
Chun Y Wong, Hani Al-Salami, Crispin R Dass
Diabetes mellitus is a chronic metabolic health disease affecting the homeostasis of blood sugar levels. However, subcutaneous injection of insulin can lead to patient non-compliance, discomfort, pain and local infection. Sub-micron sized drug delivery systems have gained attention in oral delivery of insulin for diabetes treatment. In most of the recent literature, the terms "microparticles" and "nanoparticle" refer to particles where the dimensions of the particle are measured in micrometers and nanometers respectively...
December 26, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29285427/physician-perceptions-of-blood-pressure-control-in-patients-with-chronic-kidney-disease-and-target-blood-pressure-achievement-rate
#11
Ran-Hui Cha, Hajeong Lee, Jung Pyo Lee, Young Rim Song, Sung Gyun Kim, Yon Su Kim
Background: Blood pressure (BP) control is the most-established method for the prevention of chronic kidney disease (CKD) progression. However, the ideal BP target for CKD patients is still under debate. Methods: We performed a survey of regular registered members of the Korean Society of Nephrology to determine physician perceptions of BP control in patients with CKD. In addition, we evaluated the target BP achievement rate using data from the APrODiTe-2 study...
December 2017: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/29274796/-compliance-with-treatment-in-wilson-s-disease-on-the-interest-of-a-multidisciplinary-closer-follow-up
#12
E Jacquelet, J Beretti, A De-Tassigny, N Girardot-Tinant, E Wenisch, A Lachaux, M-C Pheulpin, A Poujois, F Woimant
BACKGROUND: Compliance with treatment is very important for patients who suffer from Wilson's disease, a rare genetic disorder. They can benefit a long-life and effective treatment. The purpose of our study is to identify the level of compliance in Wilson's disease patients and features associated with compliance as well. METHODS: This is a prospective study carried out in the National Reference Center for Wilson Disease (based in Paris and Lyon) over a 8 months period...
December 20, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29242394/a-qrm-discussion-of-microbial-contamination-of-non-sterile-drug-products-using-fda-s-and-ema-s-warning-letters-between-2008-and-2016
#13
Ana M C Santos, Mara S Doria, Luis Soares, António J Almeida, José C Menezes
Microbial quality control of non-sterile drug products is a concern to regulatory agencies and the pharmaceutical industry since the 1960's. Despite being an old challenge to companies, microbial contamination still affects a high number of manufacturers of non-sterile products. Consequences go well beyond the obvious direct costs related to batch rejections or product recalls, as human lives and a company's reputation are significantly impacted as well if such event occurs. To better manage this type of events and establish effective mitigation strategies, it is necessary to understand the microbial hazards involved in the manufacturing processes of non-sterile drug products, be able to evaluate their potential impact on final product quality and apply mitigation actions ...
December 14, 2017: PDA Journal of Pharmaceutical Science and Technology
https://www.readbyqxmd.com/read/29239056/association-of-body-mass-index-and-weight-gain-patterns-with-albumin-excretion-in-pregnancy
#14
Özlem B Tulmaç, Zeynep Ö Dağ, Funda Erdoğan, Cemile D Sayan, Nevin Sağsöz
AIM: We examined body mass index (BMI) and gestational weight gain (GWG) patterns of pregnant women and investigated the impact of these factors on the urinary albumin-creatinine ratio (ACR) during pregnancy. METHODS: The data of 163 women whose basal BMI and ACR were measured during the first trimester were used in this study. Body weight alone between 12-16 weeks and body weight together with ACR after 37 weeks of gestation were measured. RESULTS: Overall, 46% of women were overweight or obese, 60...
December 14, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29235431/using-targeted-solution-tools-as-an-initiative-to-improve-hand-hygiene-challenges-and-lessons-learned
#15
J A Al-Tawfiq, M Treble, R Abdrabalnabi, C Okeahialam, S Khazindar, S Myers
The Joint Commission Centre for Transforming Healthcare's Web-based Targeted Solutions Tool (TST) for improving hand hygiene was implemented to elucidate contributing factors to low compliance rates of hand hygiene. Monitoring of compliance was done by trained unknown and known observers and rates of hospital-acquired infections were tracked and correlated against the changes in hand hygiene compliance. In total, 5669 of hand hygiene observations were recorded by the secret observers. The compliance rate increased from 75·4% at baseline (May-August 2014) to 88·6% during the intervention (13 months) and the control periods (P < 0·0001)...
December 13, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/29227773/non-compliance
#16
Kirsten Due
No abstract text is available yet for this article.
December 11, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/29222612/how-do-parents-manage-irritability-challenging-behaviour-non-compliance-and-anxiety-in-children-with-autism-spectrum-disorders-a-meta-synthesis
#17
Elizabeth O'Nions, Francesca Happé, Kris Evers, Hannah Boonen, Ilse Noens
Although there is increasing research interest in the parenting of children with ASD, at present, little is known about everyday strategies used to manage problem behaviour. We conducted a meta-synthesis to explore what strategies parents use to manage irritability, non-compliance, challenging behaviour and anxiety in their children with ASD. Approaches included: (1) accommodating the child; (2) modifying the environment; (3) providing structure, routine and occupation; (4) supervision and monitoring; (5) managing non-compliance with everyday tasks; (6) responding to problem behaviour; (7) managing distress; (8) maintaining safety and (9) analysing and planning...
December 8, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29215022/mineral-analysis-of-complete-dog-and-cat-foods-in-the-uk-and-compliance-with-european-guidelines
#18
M Davies, R Alborough, L Jones, C Davis, C Williams, D S Gardner
Mineral content of complete pet food is regulated to ensure health of the companion animal population. Analysis of adherence to these regulatory guidelines has not been conducted. Here, mineral composition of complete wet (n = 97) and dry (n = 80) canine and feline pet food sold in the UK was measured to assess compliance with EU guidelines. A majority of foods complied with ≥8 of 11 guidelines (99% and 83% for dry and wet food, respectively), but many failed to provide nutritional minimum (e.g. Cu, 20% of wet food) or exceeded nutritional maximum (e...
December 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29214027/to-what-extent-do-prescribing-practices-for-hypertension-in-the-private-sector-in-zimbabwe-follow-the-national-treatment-guidelines-an-analysis-of-insurance-medical-claims
#19
Victor Basopo, Paschal N Mujasi
Background: Hypertension is the most prevalent cardiovascular disease in Zimbabwe. The prevalence of Hypertension in the country is above 30% regardless of the cut off used. Currently, majority of patients in Zimbabwe seek health care from the private sector due to limited government funding for the public health sector. However, Standard treatment guidelines for hypertension are only available in the public sector and are optional in the private sector. This study assesses compliance of private sector prescribing to Standard Treatment guidelines for hypertension...
2017: Journal of Pharmaceutical Policy and Practice
https://www.readbyqxmd.com/read/29209160/molecular-mechanisms-of-antipsychotic-drug-induced-diabetes
#20
REVIEW
Jiezhong Chen, Xu-Feng Huang, Renfu Shao, Chen Chen, Chao Deng
Antipsychotic drugs (APDs) are widely prescribed to control various mental disorders. As mental disorders are chronic diseases, these drugs are often used over a life-time. However, APDs can cause serious glucometabolic side-effects including type 2 diabetes and hyperglycaemic emergency, leading to medication non-compliance. At present, there is no effective approach to overcome these side-effects. Understanding the mechanisms for APD-induced diabetes should be helpful in prevention and treatment of these side-effects of APDs and thus improve the clinical outcomes of APDs...
2017: Frontiers in Neuroscience
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