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Non-adherence

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https://www.readbyqxmd.com/read/29220622/regimen-difficulty-and-medication-non-adherence-and-the-interaction-effects-of-gender-and-age
#1
Vidya Dalvi, Nandakumar Mekoth
Medication non-adherence is a global health issue. Numerous factors predict it. This study is aimed to identify the association between regimen difficulty and medication non-adherence among patients with chronic conditions and testing the interaction effects of gender and age on the same. It was a cross-sectional study conducted among 479 outpatients from India. Convenience sampling method was used. Multiple regression analyses were performed to find the predictors of non-adherence and to test interaction effects...
December 8, 2017: Hospital Topics
https://www.readbyqxmd.com/read/29220386/does-cognitive-impairment-impact-adherence-a-systematic-review-and-meta-analysis-of-the-association-between-cognitive-impairment-and-medication-non-adherence-in-stroke
#2
Daniela Rohde, Niamh A Merriman, Frank Doyle, Kathleen Bennett, David Williams, Anne Hickey
BACKGROUND: While medication adherence is essential for the secondary prevention of stroke, it is often sub-optimal, and can be compromised by cognitive impairment. This study aimed to systematically review and meta-analyse the association between cognitive impairment and medication non-adherence in stroke. METHODS: A systematic literature search of longitudinal and cross-sectional studies of adults with any stroke type, which reported on the association between any measure of non-adherence and cognitive impairment, was carried out according to PRISMA guidelines...
2017: PloS One
https://www.readbyqxmd.com/read/29220062/community-academic-partnership-to-implement-a-breast-and-cervical-cancer-screening-education-program-in-puerto-rico
#3
Vivian Colón-López, Daisy González, Camille Vélez, Natalie Fernández-Espada, Alana Feldman-Soler, Kelly Ayala-Escobar, Alelí M Ayala-Marín, Marievelisse Soto-Salgado, William A Calo, Angela Pattatucci-Aragón, Marinilda Rivera-Díaz, María E Fernández
OBJECTIVE: To describe how a community-academic partnership between Taller Salud Inc., a community-based organization, and the Puerto Rico Community Cancer Control Outreach Program of the University of Puerto Rico was crucial in the adaptation and implementation of Cultivando La Salud (CLS), an evidencebased educational outreach program designed to increase breast and cervical cancer screening among Hispanic women living in Puerto Rico. This collaboration facilitated the review and adaptation of the CLS intervention to improve cultural appropriateness, relevance, and acceptability for Puerto Rican women...
December 2017: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/29218760/a-systematic-review-of-immunosuppressant-adherence-interventions-in-transplant-recipients-decoding-the-streetlight-effect
#4
REVIEW
S Duncan, R A Annunziato, C Dunphy, D LaPointe Rudow, B L Shneider, E Shemesh
Non-adherence to immunosuppressant medications is an important risk factor for graft dysfunction. To evaluate the effectiveness of adherence-enhancing interventions, we reviewed adherence intervention studies in solid organ transplant recipients (all ages). Using the following databases: PsycINFO, PubMed, Scopus, and ScienceDirect, we identified 41 eligible studies. Only three non-randomized trials showed a possible positive effect on objective indicators of transplant outcomes (such as rejection, liver enzyme levels, kidney function)...
December 7, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/29218008/improving-the-adherence-to-antiretroviral-therapy-a-difficult-but-essential-task-for-a-successful-hiv-treatment-clinical-points-of-view-and-practical-considerations
#5
REVIEW
Simona A Iacob, Diana G Iacob, Gheorghita Jugulete
HIV infection is responsible for one the most devastating human pandemics. The advent of antiretroviral therapy has changed the course of the pandemic and saved millions of lives. Complex therapeutic regimens have been introduced since 1996 and have contributed to the transformation of HIV infection into a treatable chronic diseases. New types of potent antiretrovirals and their combinations, including "once daily" treatment, have simplified the regimens and diminished side effects. Nevertheless the adherence to antiretroviral therapy remains unsatisfactory and varies between 27 and 80% across different population in various studies, compared with the required level of 95%...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29217949/the-effect-of-psychosocial-factors-and-patients-perception-of-tuberculosis-treatment-non-adherence-in-addis-ababa-ethiopia
#6
Habteyes Hailu Tola, Gholamreza Garmaroudi, Davoud Shojaeizadeh, Azar Tol, Mir Saeed Yekaninejad, Luche Tadesse Ejeta, Abebaw Kebede, Desta Kassa
Background: Although there are several studies reported on factors affecting tuberculosis (TB) treatment non-adherence, there is information gap on psychosocial and patients' perceptions aspects. Therefore, this study was aimed to investigate the effect of psychosocial factors and patients' perceptions on TB treatment non-adherence in Ethiopia. Methods: A cross sectional study was conducted in Addis Ababa from May to December, 2014. Thirty one health facilities were randomly selected and 698 TB patients, who had been on treatment, were enrolled consecutively using patient registration number...
September 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29217315/predictors-of-effective-therapeutic-relationships-between-pharmacists-and-patients-with-type-2-diabetes-comparison-between-arabic-speaking-and-caucasian-english-speaking-patients
#7
H Alzubaidi, K Mc Namara, V L Versace
BACKGROUND: The benefits of pharmacist-led interventions in achieving desired patient outcomes have been well established. Effective patient-pharmacist relationships are required to provide high-quality pharmacy care. Limited information is available about how Arabic-speaking migrants with diabetes, in Australia, perceive patient-pharmacist relationship and how these perspectives differ from the mainstream society (represented by Caucasian English-speaking people). OBJECTIVE: To examine and compare the patient-pharmacist relationship, medication underuse and adherence levels among Arabic-speaking and Caucasian English-speaking patients with type 2 diabetes...
November 23, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/29215337/adherence-to-nucleoside-nucleotide-analogue-treatment-in-patients-with-chronic-hepatitis-b
#8
Emin Ediz Tütüncü, Rahmet Güner, Yunus Gürbüz, Ayşe Kaya Kalem, Barış Öztürk, İmran Hasanoğlu, İrfan Şencan, Mehmet A Taşyaran
BACKGROUND: Adherence to medication is an important aspect of preventing drug resistance and treatment failure in patients receiving nucleos(t)ide analogues for chronic hepatitis B. AIMS: To assess adherence to nucleoside/nucleotide analogues in chronic hepatitis B treatment and to determine factors associated with non-adherence. STUDY DESIGN: Cross-sectional study. METHODS: The study enrolled 85 chronic hepatitis B patients who had been receiving nucleoside/nucleotide analogues for ≥3 months...
December 1, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/29213512/transient-gerstmann-syndrome-as-manifestation-of-stroke-case-report-and-brief-literature-review
#9
Rafael Batista João, Raquel Mattos Filgueiras, Marcelo Lucci Mussi, João Eliezer Ferri de Barros
Gerstmann Syndrome (GS) is a rare neurological condition described as a group of cognitive changes corresponding to a tetrad of symptoms comprising agraphia, acalculia, right-left disorientation and finger agnosia. It is known that some specific brain lesions may lead to such findings, particularly when there is impairment of the angular gyrus and adjacent structures. In addition, the possibility of disconnection syndrome should be considered in some cases. The purpose of this article is to report a case of a young, cardiac patient, non-adherent to treatment, who presented with a stroke in which transient clinical symptoms were compatible with the tetrad of GS...
April 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29210834/pre-exposure-prophylaxis-prep-use-and-condomless-anal-sex-evidence-of-risk-compensation-in-a-cohort-of-young-men-who-have-sex-with-men
#10
Michael E Newcomb, Kevin Moran, Brian A Feinstein, Emily Forscher, Brian Mustanski
BACKGROUND: Young men who have sex with men (YMSM) are disproportionately impacted by HIV. Pre-exposure prophylaxis (PrEP) is highly effective at preventing HIV acquisition. It remains unclear if PrEP use increases rates of condomless sex (i.e., risk compensation), which may increase risk of infection if PrEP adherence is not optimal. This study aimed to examine whether PrEP use and PrEP adherence were associated with change in sexual risk behaviors in a large longitudinal cohort of YMSM reporting on multiple sexual partnerships over time...
November 27, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29209982/adherence-to-inhaled-medications-and-its-effect-on-healthcare-utilization-and-costs-among-high-grade-chronic-obstructive-pulmonary-disease-patients
#11
Jee-Ae Kim, Min Kyoung Lim, Kunil Kim, JuHee Park, Chin Kook Rhee
BACKGROUND: Adherence to inhaled medication regimens affects chronic obstructive pulmonary disease (COPD) prognosis and quality of life, and reduces the use of healthcare services, resulting in cost savings. OBJECTIVES: To examine the effects of adherence to inhaled medication regimens on healthcare utilization and costs in high-grade COPD patients. METHODS: We performed an observational retrospective cohort study using a longitudinal data set from the Korean Health Insurance Review and Assessment Service (2008-2013) containing healthcare services' information for 50 million beneficiaries...
December 5, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/29208627/generation-and-characterisation-of-two-d2a1-mammary-cancer-sublines-to-model-spontaneous-and-experimental-metastasis-in-a-syngeneic-balb-c-host
#12
Ute Jungwirth, Antoinette van Weverwijk, Miriam J Melake, Ann F Chambers, Qiong Gao, Marc Fivaz, Clare M Isacke
Studying the complex mechanisms underlying breast cancer metastasis and therapy response necessitates relevant in vivo models, particularly syngeneic models with an intact immune system. Two syngeneic spontaneously metastatic sublines, D2A1-m1 and D2A1-m2, were generated from the poorly metastasising BALB/c-derived D2A1 cell line by serial in vivo passaging. In vivo and in vitro analyses revealed distinct and shared characteristics of the metastatic D2A1-m1 and D2A1-m2 sublines. In particular, D2A1-m1 cells are more aggressive in experimental metastasis assays, while D2A1-m2 cells are more efficient at disseminating from the primary tumour in spontaneous metastasis assays...
November 30, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29208047/non-conventional-dosing-of-oral-anticancer-agents-in-oncology-and-malignant-haematology-a-systematic-review-protocol
#13
Faouzi Djebbari, Nicola Stoner, Verna Lavender
BACKGROUND: Recent advances in cancer therapeutics have resulted in significantly improved overall survival and progression-free survival for patients. Targeted oral systemic anticancer therapies (SACT) offer a range of treatment approaches that differ from traditional cytotoxic chemotherapy: non-cytotoxic oral SACT target malignant disease continuously, have less broad and more favourable safety profiles, which can improve patients' quality of life (QoL). Toxicities associated with daily oral SACT administration can, however, result in non-adherence and a reduced QoL...
December 6, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29205855/multi-level-factors-are-associated-with-immunosuppressant-nonadherence-in-heart-transplant-recipients-the-international-bright-study
#14
Kris Denhaerynck, Lut Berben, Fabienne Dobbels, Cynthia L Russell, Marisa G Crespo-Leiro, Alain Jean Poncelet, Sabina De Geest
Factors at the level of family/healthcare worker-, organization- and system are neglected in medication nonadherence research in heart transplantation (HTx). The four-continent, eleven-country cross-sectional BRIGHT study used multi-staged sampling to examine 36 HTx centers, including 36 HTx directors, 100 clinicians, and 1397 patients. Nonadherence to immunosuppressants-defined as any deviation in taking or timing adherence and/or dose reduction-was assessed using the BAASIS® interview. Guided by the Integrative Model of Behavioral Prediction and Bronfenbrenner's ecological model, we analyzed factors at these multiple levels using sequential logistic regression analysis (6 blocks)...
December 5, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/29205755/short-term-outcomes-of-pediatric-liver-transplant-recipients-after-transition-to-adult-healthcare-service
#15
Alberto Ferrarese, Giacomo Germani, Silvia Lazzaro, Mara Cananzi, Francesco Paolo Russo, Marco Senzolo, Martina Gambato, Alberto Zanetto, Umberto Cillo, Enrico Gringeri, Giorgio Perilongo, Patrizia Burra
BACKGROUND AND AIMS: Survival rates after liver transplantation (LT) in pediatric recipients has significantly improved overtime. However, data regarding outcomes after transition from Pediatric to Adult Healthcare Service (AHS) are still lacking. Therefore, we aimed to prospectively evaluate the outcome of LT recipients after transition; to access patients' non-adherence and identify potential risk factors for non-adherence. METHODS: All consecutive adolescent LT recipients moving to the AHS at Padua University Hospital were evaluated between 2010-2015...
December 5, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29204583/osa-treatment-history-in-an-upper-airway-stimulation-trial-cohort
#16
Ryan J Soose, Tapan A Padhya, M Boyd Gillespie, Oleg Froymovich, Ho-Sheng Lin, B Tucker Woodson
Objectives: Analyze the obstructive sleep apnea (OSA) treatment history in a group of participants who enrolled in a hypoglossal nerve stimulation trial. Methods: Moderate-severe OSA patients with difficulty adhering to CPAP presented for enrollment in a multicenter trial. Self-reported history on prior OSA medical therapy was collected at enrollment, including OSA diagnosis date, CPAP start and stop dates, oral appliance trial, and reasons for discontinuation or non-adherence...
June 2017: World journal of otorhinolaryngology—head and neck surgery
https://www.readbyqxmd.com/read/29203418/electronic-medical-records-can-be-used-to-emulate-target-trials-of-sustained-treatment-strategies
#17
Goodarz Danaei, Luis Alberto García Rodríguez, Oscar Fernández Cantero, Roger W Logan, Miguel A Hernán
OBJECTIVE: To emulate three target trials: single treatment versus no treatment, joint treatment versus no treatment, and head-to-head comparison of two treatments. We explain how to estimate the observational analogs of intention-to-treat and per-protocol effects, using hazard ratios and survival curves. For per-protocol effects, we describe two methods for adherence adjustment via inverse-probability weighting. STUDY DESIGN AND SETTING: Prospective observational study using electronic medical records of individuals aged 55-84 with coronary heart disease from >500 practices in the United Kingdom between 2000-2010...
December 1, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29203408/medication-non-adherence-and-uncertainty-information-seeking-and-processing-in-the-danish-lifestat-survey
#18
Margit Kriegbaum, Sofie Rosenlund Lau
BACKGROUND: Statins are widely prescribed to lower cardiovascular morbidity and mortality. However, statin non-adherence is very high. PURPOSE: The aim of this paper was to investigate reasons for stopping statin treatment in the general population and to study how aspects of information-seeking and processing is associated with statin non-adherence. METHODS: This study used a population survey on 3050 Danish residents aged 45-65 years. Reasons for statin discontinuation was studied among those who were previous statin users...
September 23, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/29202857/medication-adherence-and-its-associated-factors-among-diabetic-patients-at-zewditu-memorial-hospital-addis-ababa-ethiopia
#19
Muhammed Ali, Tigestu Alemu, Oumer Sada
OBJECTIVE: Diabetes is a global problem with devastating human, social and economic impact. Anti-diabetic medications play a major role in the glycemic control of patients with diabetes. However, inadequate adherence compromises safety and treatment effectiveness, leading to increased mortality and morbidity. The aim of this study was to assess adherence to anti-diabetic medications and associated factors among patient with diabetes mellitus receiving care at Zewditu Memorial Hospital...
December 4, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29199370/measuring-medication-adherence-in-older-community-dwelling-patients-with-multimorbidity
#20
San Kim, Kathleen Bennett, Emma Wallace, Tom Fahey, Caitriona Cahir
PURPOSE: Older people with several chronic conditions require multiple drugs from different classes to be adequately treated. This study aims to: (i) measure medication adherence across multiple conditions and therapeutic drug groups in older community-dwelling patients, and (ii) examine the effect of multimorbidity on adherence. METHODS: This is a retrospective cohort study of medication adherence in 855 community-dwelling patients aged ≥ 70 years from 15 practices in Ireland using the Health Service Executive Primary Care Reimbursement Service (HSE-PCRS) pharmacy claims database...
December 3, 2017: European Journal of Clinical Pharmacology
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