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Non-adherence

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https://www.readbyqxmd.com/read/29450784/-a-challenging-decision-making-process-pro-or-con-surgical-heart-valve-replacement-in-a-case-of-long-term-non-adherence-a-case-report
#1
René Florian Oswald, H Christof Müller-Busch
A young, still multimorbid woman aquires infectious endocarditis. Anamnestically severe non-adherence concerning medical advice is reported. Complete cure may only be achieved by performing surgical heart valve replacement, which implies lifelong scrupulous oral anticoagulation postoperatively. Discussion evolves within medical staff, whether surgery should be indicated or not.
February 15, 2018: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29450684/application-and-impact-of-run-in-studies
#2
Michael Fralick, Jerry Avorn, Jessica M Franklin, Abdurrahman Abdurrob, Aaron S Kesselheim
BACKGROUND: A run-in phase is often employed prior to randomization in a clinical trial to exclude non-adherent patients, placebo responders, active drug non-responders, or patients who do not tolerate the active drug. This may impact the generalizability of trial results. OBJECTIVE: To determine if clinical outcomes differed between randomized controlled trials with run-in phases compared with randomized controlled trials of the same medication without run-in phases...
February 15, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29446874/transplant-recipients-are-vulnerable-under-the-medicare-part-d-benefit
#3
Lisa M Potter, Angela Q Maldonado, Krista L Lentine, Mark A Schnitzler, Zidong Zhang, Gregory P Hess, Edward Garrity, Bertram L Kasiske, David A Axelrod
Transplant immunosuppressants are often used off-label due to insufficient randomized prospective trial data to achieve organ-specific US Food and Drug Administration (FDA) approval. Transplant recipients who rely on Medicare Part D for immunosuppressant drug coverage are vulnerable to coverage denial for off-label prescriptions, unless use is supported by Centers for Medicare & Medicaid Services (CMS)-approved compendia. An integrated data set including national transplant registry data and 3 years of dispensed pharmacy records was used to identify the prevalence of immunosuppression use that is both off-label and not supported by CMS-approved compendia...
February 15, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29445730/pilot-study-of-a-smartphone-application-designed-to-socially-motivate-cardiovascular-disease-patients-to-improve-medication-adherence
#4
Saki Fujita, Isaree Pitaktong, Graeme Vosit Steller, Victor Dadfar, Qinwen Huang, Sindhu Banerjee, Richard Guo, Hien Tan Nguyen, Robert Harry Allen, Seth Shay Martin
Background: Social support received by patients from family and community has been identified as a key factor for success in improving medication adherence in those patients. This pilot study aimed to investigate the usability and feasibility of PillPal, a smartphone application that uses video-chatting as a social motivation medium to encourage medication adherence in cardiovascular disease (CVD) patients. We additionally gathered feedback on the Physician Calendar, an accompanying web platform that allows clinicians to view patient adherence data generated from the app...
2018: MHealth
https://www.readbyqxmd.com/read/29439280/-adherence-to-immunosuppressive-medication-following-organ-transplantation
#5
Mariel Nöhre, Yesim Erim, Frank Vitinius, Felix Klewitz, Mario Schiffer, Martina de Zwaan
Organ transplantation is the best and to some extent only option for many patients with chronic organ failure. Usually after successful transplantation patients experience a significant improvement of their condition. Nevertheless, they are not cured but still chronically ill. Living with an organ transplant requires consequent immunosuppression intake, regular physician visits and following the recommendations regarding infection prevention. These factors are important to secure a long transplant survival...
February 13, 2018: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/29436331/impact-of-adherence-to-antidepressants-on-long-term-prescription-opioid-use-cessation
#6
Jeffrey F Scherrer, Joanne Salas, Mark D Sullivan, Brian K Ahmedani, Laurel A Copeland, Kathleen K Bucholz, Thomas Burroughs, F David Schneider, Patrick J Lustman
BACKGROUND: Depression contributes to persistent opioid analgesic use (OAU). Treating depression may increase opioid cessation. Aims To determine if adherence to antidepressant medications (ADMs) v. non-adherence was associated with opioid cessation in patients with a new depression episode after >90 days of OAU. METHOD: Patients with non-cancer, non-HIV pain (n = 2821), with a new episode of depression following >90 days of OAU, were eligible if they received ≥1 ADM prescription from 2002 to 2012...
February 2018: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/29435910/the-impact-of-cardiovascular-medication-use-on-patients-daily-lives-a-cross-sectional-study
#7
Danielle M van der Laan, Petra J M Elders, Christel C L M Boons, Giel Nijpels, Janet Krska, Jacqueline G Hugtenburg
Background The management of multiple long-term medicines of patients with chronic diseases creates a burden for patients. However, limited research is performed on its impact on patients' daily lives. Objective The aim of this study was to explore the impact of cardiovascular medication on different daily life aspects and to examine differences of these aspects between adherent and non-adherent patients. Setting Two community pharmacies in the Netherlands. Method In this cross-sectional study patients (≥ 45 years) using cardiovascular medication participated...
February 12, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29426802/development-of-mycoplasma-pneumoniae-biofilms-in-vitro-and-the-limited-role-of-motility
#8
Monica Feng, Andrew C Schaff, Sara A Cuadra Aruguete, Hailey E Riggs, Steven L Distelhorst, Mitchell F Balish
Mycoplasma pneumoniae is a bacterial pathogen of humans that is a major causative agent of chronic respiratory disease. M. pneumoniae infections often recur even after successful treatment of symptoms with antibiotics, and resistance to antibiotics is increasing worldwide, with nearly complete resistance in some places. Although biofilms often contribute to chronicity and resistance, M. pneumoniae biofilms remain poorly characterized. Scanning electron microscopy revealed that cells of wild-type (WT) M. pneumoniae strain M129 biofilms, as well as mutants II-3 and II-3R, in vitro became increasingly rounded as the biofilm towers matured over 5 days...
February 7, 2018: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/29425664/topical-testosterone-therapy-adherence-and-outcomes-among-men-with-primary-or-secondary-hypogonadism
#9
Michael Grabner, Zsolt Hepp, Amit Raval, Fang Tian, Mohit Khera
BACKGROUND: Men with primary or secondary hypogonadism (HG) prescribed testosterone therapy (TTh) who terminate treatment early might not obtain the benefit of symptom relief. AIM: To estimate adherence to topical TTh and to compare baseline characteristics and follow-up outcomes between adherent and non-adherent patients in a population of commercially insured US men with primary or secondary HG. METHODS: A retrospective cohort of adult men with primary or secondary HG and initiating topical TTh from 2007 through 2014, with continuous coverage during 12-month baseline and follow-up periods, was identified from a large US health plan...
February 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29420613/patient-reported-adherence-to-statin-therapy-barriers-to-adherence-and-perceptions-of-cardiovascular-risk
#10
Vicki Fung, Ilana Graetz, Mary Reed, Marc G Jaffe
BACKGROUND: Patient reports of their adherence behaviors, concerns about statins, and perceptions of atherosclerotic cardiovascular disease (ASCVD) risk could inform approaches for improving adherence to statin therapy. We examined these factors and their associations with adherence. METHODS: We conducted telephone interviews among a stratified random sample of adults receiving statins within an integrated delivery system (N = 730, 81% response rate) in 2010. We sampled equal numbers of individuals in three clinical risk categories: those with 1) coronary artery disease; 2) diabetes or other ASCVD diagnosis; and 3) no diabetes or ASCVD diagnoses...
2018: PloS One
https://www.readbyqxmd.com/read/29417739/seventeen-year-nationwide-trends-in-use-of-long-acting-bronchodilators-and-inhaled-corticosteroids-among-adults-a-danish-drug-utilization-study
#11
Mette Reilev, Anton Pottegård, Jesper Rømhild Davidsen, Lotte Rasmussen, Jens Søndergaard, Christian B Laursen, Daniel Pilsgaard Henriksen
Long-acting bronchodilators and inhaled corticosteroids (ICS) are the cornerstones in treatment of chronic obstructive and inflammatory pulmonary diseases. However, non-adherence to guidelines is widespread. Detailed information on real-life treatment patterns is needed to promote rational use. We aimed to investigate nationwide time trends in individual-level treatment patterns of long-acting bronchodilators and ICS. Using nationwide Danish health registries, we identified all Danish adults with a prescription for long-acting bronchodilators and/or ICS from 2000-2016...
February 8, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29416318/adherence-to-dietary-recommendations-in-diabetes-mellitus-disease-acceptance-as-a-potential-mediator
#12
Mariusz Jaworski, Mariusz Panczyk, Małgorzata Cedro, Alicja Kucharska
Background: Adherence by diabetic patients to dietary recommendations is important for effective therapy. Considering patients' expectations in case of diet is significant in this regard. The aim of this paper was to analyze the relationship between selected independent variables (eg, regular blood glucose testing) and patients' adherence to dietary recommendations, bearing in mind that the degree of disease acceptance might play a mediation role. Subjects and methods: A cross-sectional study was conducted in 91 patients treated for type 2 diabetes mellitus in a public medical facility...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29415657/assessment-of-blood-pressure-control-in-adult-hypertensive-patients-in-eastern-sudan
#13
Saeed M Omar, Osama Elnour, Gamal K Adam, Osman E Osman, Ishag Adam
BACKGROUND: The rate of blood pressure (BP) control in adult hypertensive patients is poor and the reasons for poor control of BP pressure are not fully understood globally. This study aimed to assess the rate and factors associated with BP control in adult hypertensive patients in Sudan. METHODS: A hospital-based cross-sectional study was conducted in adult hypertensive Sudanese patients at Gadarif Hospital in eastern Sudan from November 2016 to March 2017. Information on sociodemographic characteristics of the participants, comorbidities, antihypertensive medication, and adherence to antihypertensive medication was gathered from patients using a questionnaire...
February 7, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29413459/212pb-labeled-b7-h3-targeting-antibody-for-pancreatic-cancer-therapy-in-mouse-models
#14
Benjamin B Kasten, Abhishek Gangrade, Harrison Kim, Jinda Fan, Soldano Ferrone, Cristina R Ferrone, Kurt R Zinn, Donald J Buchsbaum
INTRODUCTION: We recently validated monoclonal antibody (mAb) 376.96 as an effective carrier for targeted α-particle radioimmunotherapy (RIT) with 212Pb in ovarian cancer mouse models. In this study, we tested the binding of radiolabeled mAb 376.96 to human pancreatic ductal adenocarcinoma (PDAC) cells and localization in xenografts in immune-deficient mice and evaluated 212Pb-labeled 376.96 (212Pb-376.96) for PDAC therapy. METHODS: In vitro Scatchard assays assessed the specific binding of 212Pb-376...
December 24, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29411073/demand-and-capacity-to-integrate-pelvic-organ-prolapse-and-genital-fistula-services-in-low-resource-settings
#15
Vandana Tripathi, Sohier Elneil, Lauri Romanzi
INTRODUCTION AND HYPOTHESIS: There is a need for expanded access to safe surgical care in low- and middle-income countries (LMICs) as illustrated by the report of the 2015 Lancet Commission on Global Surgery. Packages of closely-related surgical procedures may create platforms of capacity that maximize impact in LMIC. Pelvic organ prolapse (POP) and genital fistula care provide an example. Although POP affects many more women in LMICs than fistula, donor support for fistula treatment in LMICs has been underway for decades, whereas treatment for POP is usually limited to hysterectomy-based surgical treatment, occurring with little to no donor support...
February 6, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29405487/history-of-psychosis-and-mania-and-outcomes-after-kidney-transplantation
#16
Miklos Z Molnar, James D Eason, Abduzhappar Gaipov, Manish Talwar, Praveen K Potukuchi, Kiran Joglekar, Adam Remport, Zoltan Mathe, Istvan Mucsi, Marta Novak, Kamyar Kalantar-Zadeh, Csaba P Kovesdy
History of psychosis or mania, if uncontrolled, both represent relative contraindications for kidney transplantation. We examined 3,680 US veterans who underwent kidney transplantation. The diagnosis of history of psychosis/mania was based on a validated algorithm. Measured confounders were used to create a propensity score-matched cohort (n=442). Associations between pre-transplantation psychosis/mania and death with functioning graft, all-cause death, graft loss and rejection were examined in survival models and logistic regression models...
February 6, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29397583/post-stroke-hypertension-control-and-receipt-of-health-care-services-among-veterans
#17
Dhanashri D Kohok, Jason J Sico, Fitsum Baye, Laura Myers, Jessica Coffing, Masoor Kamalesh, Dawn M Bravata
Many ischemic stroke patients do not achieve goal blood pressure (BP < 140/90 mm Hg). To identify barriers to post-stroke hypertension management, we examined healthcare utilization and BP control in the year after index ischemic stroke admission. This retrospective cohort study included patients admitted for acute ischemic stroke to a VA hospital in fiscal year 2011 and who were discharged with a BP ≥ 140/90 mm Hg. One-year post-discharge, BP trajectories, utilization of primary care, specialty and ancillary services were studied...
February 4, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29396760/interventions-to-improve-endocrine-therapy-adherence-in-breast-cancer-survivors-what-is-the-evidence
#18
REVIEW
Ekim Ekinci, Salima Nathoo, Thushara Korattyil, Aisha Vadhariya, Hanna A Zaghloul, Polly A Niravath, Susan M Abughosh, Meghana V Trivedi
PURPOSE: Endocrine therapy reduces the risk of breast cancer recurrences and mortality in hormone receptor-positive (HR+) breast cancer survivors. However, non-adherence to treatment remains a significant problem. The aim of this study was to review current literature and ongoing trials to identify interventions employed to improve adherence to adjuvant endocrine therapy (AET) in breast cancer survivors. METHODS: We searched PubMed and the National Library of Medicine registry of clinical trials using the terms "breast cancer" and "adherence" or "compliance" and "intervention" and "medication" or "endocrine therapy" or "hormone therapy" to identify published studies as well as ongoing clinical trials...
February 2, 2018: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/29395963/what-do-patients-want-from-their-asthma-care-doctors
#19
REVIEW
Bruce K Rubin, Wei Zhao, Tonya A Winders
One of the most important causes of asthma morbidity, hospital admissions, and death is non-adherence to prescribed therapy. It is generally assumed that adherence rates can be increased with asthma education, although well conducted studies have not always supported this assumption. Education can be achieved, or can fail, in many ways and no two patients have the same needs or perceived needs. In order to better understand what children with asthma and their parents or caregivers would desire as support from their physician providers, we conducted a survey of nearly 1000 parents of asthmatic children affiliated with the Asthma and Allergy Network...
November 16, 2017: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/29393426/endoglin-cd105-and-smad4-regulate-spheroid-formation-and-the-suppression-of-the-invasive-ability-of-human-pancreatic-cancer-cells
#20
Eri Kokaji, Akiko Shimomura, Takashi Minamisaka, Takahiko Nakajima, Shigeharu Miwa, Hideki Hatta, Takeshi Nishida, Chieko Kiya, Johji Imura
In this study, we investigated the ability of pancreatic cancer cell lines to form spheroids with the aim of identifying factors involved in cell invasiveness, a property that leads to a poor prognosis in pancreatic cancer. For this purpose, 8 cell lines derived from human pancreatic cancer tissues were cultured in non-adherent culture conditions to form spheroids, as well as normal monolayers. The morphology of the cells was observed and spheroid diameters measured. mRNA expression was compared between cells cultured under both culture conditions...
February 1, 2018: International Journal of Oncology
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