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Non-adherence

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https://www.readbyqxmd.com/read/29679439/younger-age-and-language-barriers-are-associated-with-non-adherence-to-clinical-follow-up-in-hepatitis-b-treatment
#1
Heng Chi, Angie Japhary, Robert A de Man, Robert J de Knegt, Harry L A Janssen, Bettina E Hansen
We investigated the incidence and predictors of non-adherence towards clinic visits in chronic hepatitis B (CHB) patients on entecavir or tenofovir treatment. This was a retrospective study of CHB patients treated for at least 3 months in a tertiary referral hospital in The Netherlands. Lack of attendance in clinic visits was defined as a missed follow-up visit without notice. 338 patients (48% Caucasian, 37% Asian) were followed for a median of 3.5 years. During 1283 person-years, 183 scheduled follow-up visits were missed in 101 patients resulting in 0...
April 21, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29675402/poor-compliance-with-sepsis-guidelines-in-a-tertiary-care-children-s-hospital-emergency-room
#2
Benjamin Louis Moresco, Clinton Woosley, Morris Sauter, Utpal Bhalala
Objectives: This study aimed to assess factors related to adherence to the Pediatric Advanced Life Support guidelines for severe sepsis and septic shock in an emergency room (ER) of a tertiary care children's hospital. Methods: This was a retrospective, observational study of children (0-18 years old) in The Children's Hospital of San Antonio ER over 1 year with the International Consensus Definition Codes, version-9 (ICD-9) diagnostic codes for "severe sepsis" and "shocks...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29671768/managing-complexity-exploring-decision-making-on-medication-by-young-adults-with-adhd
#3
Louise C Druedahl, Sofia Kälvemark Sporrong
Attention-deficit hyperactivity disorder (ADHD) causes difficulties with hyperactivity, impulsivity and inattention. Treatment of ADHD includes both medication and non-pharmacological options. Knowledge of treatment preferences by young adults with ADHD is sparse. The objective of this study was to explore the beliefs and experiences of young adults with ADHD related to their medication treatment decisions. Data were collected in Denmark in 2016 through a focus group and individual in-depth interviews. Conventional content analysis was used...
April 19, 2018: Pharmacy (Basel, Switzerland)
https://www.readbyqxmd.com/read/29671113/personal-and-clinical-social-support-and-adherence-to-adjuvant-endocrine-therapy-among-hormone-receptor-positive-breast-cancer-patients-in-an-integrated-health-care-system
#4
Candyce H Kroenke, Dawn L Hershman, Scarlett L Gomez, Sara R Adams, Elizabeth H Eldridge, Marilyn L Kwan, Isaac J Ergas, Ai Kubo, Lawrence H Kushi
PURPOSE: We evaluated associations between personal and clinical social support and non-adherence to adjuvant endocrine therapy (AET) in a large, Northern California breast cancer (BC) cohort from an integrated healthcare network. METHODS: This study included 3382 women from the Pathways Study diagnosed from 2005 to 2013 with stages I-III hormone receptor-positive BC and who responded to the Medical Outcomes Study Social Support and Interpersonal Processes of Care surveys, approximately 2 months post-diagnosis...
April 18, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29666309/hospital-admissions-associated-with-medication-non-adherence-a-systematic-review-of-prospective-observational-studies
#5
Pajaree Mongkhon, Darren M Ashcroft, C Norman Scholfield, Chuenjid Kongkaew
BACKGROUND: Medication non-adherence in ambulatory care has received substantial attention in the literature, but less so as it affects acute care. Accordingly, we aimed to estimate the frequency with which non-adherence to medication contributes to hospital admissions. METHODS: We searched the Cochrane Library, EMBASE, Cumulative Index to Nursing and Allied Health Literature, International Pharmaceutical Abstracts and PubMed (until December 2017) to identify prospective observational studies that examined prevalence rates of hospital admissions associated with medication non-adherence...
April 17, 2018: BMJ Quality & Safety
https://www.readbyqxmd.com/read/29665654/hypericin-affects-cancer-side-populations-via-competitive-inhibition-of-bcrp
#6
Jana Vargová, Jaromír Mikeš, Rastislav Jendželovský, Lucia Mikešová, Barbora Kuchárová, Ľubomír Čulka, Radek Fedr, Ján Remšík, Karel Souček, Alois Kozubík, Peter Fedoročko
OBJECTIVE: Cancer stem-like cells (CSLCs) are considered a root of tumorigenicity and resistance. However, their identification remains challenging. The use of the side population (SP) assay as a credible marker of CSLCs remains controversial. The SP assay relies on the elevated activity of ABC transporters that, in turn, can be modulated by hypericin (HYP), a photosensitizer and bioactive compound of St. John's Wort (Hypericum perforatum), a popular over-the-counter antidepressant. Here we aimed to comprehensively characterize the SP phenotype of cancer cells and to determine the impact of HYP on these cells...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29660488/changes-in-the-radicular-pulp-dentine-complex-in-healthy-intact-teeth-and-in-response-to-deep-caries-or-restorations-a-histological-and-histobacteriological-study
#7
Domenico Ricucci, Simona Loghin, Li-Na Niu, Franklin R Tay
INTRODUCTION: The present study reported the histological events that occurred in the radicular pulp of human mature teeth in the presence of medium/deep untreated caries lesions, and those teeth with restorations or direct pulp capping, with particular emphasis on the morphology of the canal wall dentine and the odontoblast layer. METHODS: Sixty-two teeth with medium/deep caries lesions, extensive restorations or after application of a direct pulp capping procedure were obtained from 57 subjects...
April 13, 2018: Journal of Dentistry
https://www.readbyqxmd.com/read/29658177/patterns-of-statin-use-and-long-term-adherence-and-persistence-among-older-adults-with-diabetes
#8
Richard Ofori-Asenso, Jenni Llomäki, Mark Tacey, Ella Zomer, Andrea J Curtis, J Simon Bell, Sophia Zoungas, Danny Liew
BACKGROUND: Statins reduce the risk of cardiovascular disease in patients with diabetes. We examined the prevalence of statin use and assessed the long-term adherence and persistence among people aged ≥65 years with diabetes. METHODS: Pharmaceutical Benefits Scheme data covering a 10% random sample of the Australian population were analysed. Among older adults with diabetes, the yearly prevalence of statin use was compared via Poisson regression modelling using 2006 as the reference year...
April 15, 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/29657978/relationship-between-electronically-measured-medication-adherence-and-vision-related-quality-of-life-in-a-cohort-of-patients-with-open-angle-glaucoma
#9
Atalie C Thompson, Sandra Woolson, Maren K Olsen, Susanne Danus, Hayden B Bosworth, Kelly W Muir
Objective: To investigate whether electronically measured medication adherence is associated with vision-related quality of life (VRQoL) in patients with open-angle glaucoma. Methods and analysis: This is a 3-year prospective cohort study of 79 subjects with open-angle glaucoma at a Veterans Affairs medical centre. Participants returned a medication event monitoring system (MEMS) for their glaucoma eye-drops and had at least two visits with glaucoma during the study period...
2018: BMJ Open Ophthalmology
https://www.readbyqxmd.com/read/29653218/comparing-ran-out-status-of-inhaled-short-acting-beta-agonists-in-emergency-department-patients-with-acute-asthma-1996-1998-versus-2015-2017
#10
Tadahiro Goto, Carlos A Camargo, Catalina Gimenez-Zapiola, Daniel J Pallin, Nathan I Shapiro, Thomas J Ferro, Carolyn Rainville, Stanislav Stoyanov, Kohei Hasegawa
BACKGROUND: Medication non-adherence including running out of inhaled asthma medications, is an important problem. OBJECTIVE: To examine the changes in the proportion of adults with acute asthma who ran out of their short-acting beta-agonist (SABA) inhalers before presenting to the emergency department (ED) between 1996-1998 and 2015-2017. METHODS: We analyzed data from prospective multicenter observational cohort studies of ED adult patients (aged 18-54 years) with acute asthma...
April 10, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29650487/speaking-up-about-hand-hygiene-failures-a-vignette-survey-study-among-healthcare-professionals
#11
David L B Schwappach
BACKGROUND: Speaking up by healthcare professionals (HCPs) is an important resource to reduce risks to patient safety. Due to complex tradeoffs, HCPs are often reluctant to voice their concerns. A survey investigated HCPs' likelihood to speak up. METHODS: A cross-sectional survey study among HCPs in 5 Swiss hospitals addressed speaking-up behaviors, safety climate, and likelihood to speak up about poor hand hygiene practice described in a vignette. Likelihood to speak up was analyzed using a multilevel regression model...
April 9, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29649249/optimizing-adherence-in-hiv-prevention-product-trials-development-and-psychometric-evaluation-of-simple-tools-for-screening-and-adherence-counseling
#12
Elizabeth E Tolley, Kate Morrow Guthrie, Seth Zissette, Joseph L Fava, Katherine Gill, Cheryl E Louw, Philip Kotze, Krishnaveni Reddy, Kathleen MacQueen
BACKGROUND: Low adherence in recent HIV prevention clinical trials highlights the need to better understand, measure, and support product use within clinical trials. Conventional self-reported adherence instruments within HIV prevention trials, often relying on single-item questions, have proven ineffective. While objective adherence measures are desirable, none currently exist that apply to both active and placebo arms. Scales are composed of multiple items in the form of questions or statements that, when combined, measure a more complex construct that may not be directly observable...
2018: PloS One
https://www.readbyqxmd.com/read/29644946/the-incidence-risk-factors-and-chronobiology-of-acute-myocardial-infarction-ten-years-after-hurricane-katrina
#13
John C Moscona, Matthew N Peters, Rohit Maini, Paul Katigbak, Bradley Deere, Holly Gonzales, Christopher Westley, Hassan Baydoun, Kapil Yadav, Patrick Ters, Ahmad Jabbar, Alaa Boulad, Indrajeet Mahata, Taraka V Gadiraju, Ryan Nelson, Sudesh Srivastav, Anand Irimpen
OBJECTIVE: The purpose of this study was to investigate the 10-year impact of Hurricane Katrina on the incidence of acute myocardial infarction (AMI) along with contributing risk factors and any alteration in chronobiology of AMI. METHODS: A single-center, retrospective, comparison study of AMI incidence was performed at Tulane University Health Sciences Center from 2 years before Hurricane Katrina to 10 years after Hurricane Katrina. A 6-year, pre-Katrina and 10-year, post-Katrina cohort were also compared according to pre-specified demographic, clinical, and chronobiological data...
April 12, 2018: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/29642874/pilot-evaluation-of-a-second-generation-electronic-pill-box-for-adherence-to-bedaquiline-and-antiretroviral-therapy-in-drug-resistant-tb-hiv-co-infected-patients-in-kwazulu-natal-south-africa
#14
N Bionghi, A Daftary, B Maharaj, Z Msibi, K R Amico, G Friedland, C Orrell, N Padayatchi, M R O'Donnell
BACKGROUND: The introduction of Bedaquiline, the first new antimycobacterial drug in over 40 years, has highlighted the critical importance of medication adherence in drug-resistant tuberculosis (DR-TB) treatment to prevent amplified drug-resistance and derive sustained benefit. Real-time electronic dose monitoring (EDM) accurately measures adherence and allows for titration of adherence support for anti-retroviral therapy (ART). The goal of this study was to evaluate the accuracy and acceptability of a next-generation electronic pillbox (Wisepill RT2000) for Bedaquiline-containing TB regimens...
April 11, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29629681/antibiotic-prescribing-practice-and-adherence-to-guidelines-in-primary-care-in-the-cape-town-metro-district-south-africa
#15
J Gasson, M Blockman, B Willems
BACKGROUND: Knowledge of antibiotic prescribing practice in primary care in South Africa is limited. As 80% of human antibiotic use is in primary care, this knowledge is important in view of the global problem of antibiotic resistance. OBJECTIVES: To assess antibiotic prescribing in primary care facilities in the Cape Town Metro District and compare it with current national guidelines, and to assess the reasons why prescriptions were not adherent to guidelines. METHODS: A retrospective medical record review was performed in April/May 2016...
March 28, 2018: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/29627457/relationship-of-inhaled-corticosteroid-adherence-to-asthma-exacerbations-in-patients-with-moderate-to-severe-asthma
#16
Alberto Papi, Dermot Ryan, Joan B Soriano, Henry Chrystyn, Leif Bjermer, Roberto Rodríguez-Roisin, Myrna B Dolovich, Mark Harris, Lucy Wood, Maria Batsiou, Susannah I Thornhill, David B Price
BACKGROUND: Patients with asthma and elevated blood eosinophils are at increased risk of severe exacerbations. Management of these patients should consider non-adherence to inhaled corticosteroid (ICS) therapy as a factor for increased exacerbation risk. OBJECTIVE: To investigate whether poor adherence to ICS therapy explains the occurrence of asthma exacerbations in patients with elevated blood eosinophil levels. METHODS: This historical cohort study identified patients within the Optimum Patient Care Research Database, aged ≥18 years, at Global Initiative for Asthma (GINA) steps 3 or 4, with ≥2 ICS prescriptions during the year prior to clinical review...
April 5, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29625571/language-concordant-automated-telephone-queries-to-assess-medication-adherence-in-a-diverse-population-a-cross-sectional-analysis-of-convergent-validity-with-pharmacy-claims
#17
Neda Ratanawongsa, Judy Quan, Margaret A Handley, Urmimala Sarkar, Dean Schillinger
BACKGROUND: Clinicians have difficulty accurately assessing medication non-adherence within chronic disease care settings. Health information technology (HIT) could offer novel tools to assess medication adherence in diverse populations outside of usual health care settings. In a multilingual urban safety net population, we examined the validity of assessing adherence using automated telephone self-management (ATSM) queries, when compared with non-adherence using continuous medication gap (CMG) on pharmacy claims...
April 6, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29622003/scaling-up-strategic-purchasing-analysis-of-health-system-governance-imperatives-for-strategic-purchasing-in-a-free-maternal-and-child-healthcare-programme-in-enugu-state-nigeria
#18
Daniel Chukwuemeka Ogbuabor, Obinna Emmanuel Onwujekwe
BACKGROUND: Significant knowledge gaps exist in the functioning of institutional designs and organisational practices in purchasing within free healthcare schemes in low resource countries. The study provides evidence of the governance requirements to scale up strategic purchasing in free healthcare policies in Nigeria and other low-resource settings facing similar approaches. METHODS: The study was conducted at the Ministry of Health and in two health districts in Enugu State, Nigeria, using a qualitative case study design...
April 5, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29621248/adherence-to-rivaroxaban-versus-apixaban-among-patients-with-non-valvular-atrial-fibrillation-analysis-of-overall-population-and-subgroups-of-prior-oral-anticoagulant-users
#19
Colleen A McHorney, Concetta Crivera, François Laliberté, Guillaume Germain, Willy Wynant, Patrick Lefebvre
BACKGROUND: Medication non-adherence can result in poor health outcomes. Understanding differences in adherence rates to non-vitamin K oral anticoagulants (NOACs) could guide treatment decisions and improve clinical outcomes among patients with non-valvular atrial fibrillation (NVAF). OBJECTIVE: To compare adherence to rivaroxaban and apixaban among the overall NVAF population and subgroups of prior oral anticoagulant (OAC) users (e.g., multiple comorbidities, non-adherence risk factors)...
2018: PloS One
https://www.readbyqxmd.com/read/29619492/effects-of-ramadan-fasting-on-the-symptoms-of-chronic-heart-failure
#20
Rami M Abazid, Hassan H Khalaf, Haitham I Sakr, Nora A Altorbak, Habiba S Alenzi, Zaki M Awad, Osama A Smettei, Moataz A Elsanan, Adel M Widyan, Ahmed S Azazy, Hassan W Chamsi-Pasha
OBJECTIVES: To investigate the effect of Ramadan fasting on the symptoms of chronic heart failure with a reduced ejection fraction (HFrEF). Globally, more than one billion Muslims fast during Ramadan. Data regarding the effect of fasting in heart failure patients with a reduced ejection fraction are limited. METHODS: We prospectively studied 249 outpatients with HFrEF who undertook Ramadan fasting at tertiary care cardiac center in Saudi Arabia in 2017. We obtained information regarding the clinical assessment, diagnosis, emergency department visits, and hospitalization during and in the month preceding Ramadan...
April 2018: Saudi Medical Journal
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