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https://www.readbyqxmd.com/read/27915124/a-literature-review-examining-the-barriers-to-the-implementation-of-family-witnessed-resuscitation-in-the-emergency-department
#1
REVIEW
Catherine Johnson
BACKGROUND: Caring for people near death in the Emergency Department (ED) is challenging for professionals, duty bound to respond to the needs of the dying. Family witnessed resuscitation (FWR) is practiced internationally, allowing relatives to be present at the time of a patient's death, offering comfort to the dying and aiding the bereaved along a healthy grief trajectory. AIM: The literature review elicits barriers to the implementation of FWR in the ED, examining why practice is sporadic despite numerous professional bodies calling for implementation...
November 30, 2016: International Emergency Nursing
https://www.readbyqxmd.com/read/27909535/search-for-the-ideal-antithrombotic-drug-utopian-task-likely-is-implemented-already
#2
REVIEW
Petras Stirbys Md PhD
Atrial fibrillation is the most prevalent cardiac arrhythmia with a high risk of ischemic stroke. Thromboprophylaxis plays a key role in prevention of cardioembolic and non-cardioembolic events. Oral antithrombotic drugs are most often used to reduce hypercoagulable state. Patients may suffer from both under- and overtreatment compromising the outcomes. Medication peculiarities at large are well-known and widely debated. Non-adherence to antithrombotic drug regimen poses a significant risk of stroke. There is a pressing need for more detailed delineation of risk factors, namely by incorporation of the letter "N" (meaning "Non-adherence to drug therapy") into the well-known risk score alphanumeric display: CHA2DS2N-VASc...
August 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27907919/the-impact-of-health-care-appointment-non-adherence-on-graft-outcomes-in-kidney-transplantation
#3
David J Taber, James N Fleming, Cory E Fominaya, Mulugeta Gebregziabher, Kelly J Hunt, Titte R Srinivas, Prabhakar K Baliga, John W McGillicuddy, Leonard E Egede
BACKGROUND: Non-adherence to medication is a well-studied and known cause of late allograft loss, but it is difficult to measure and prospectively monitor. The aim of this study was to assess if appointment non-adherence was correlated with medication non-adherence and a predictor of graft outcomes. METHODS: This was a longitudinal cohort study that used the National United States Renal Data System and veterans affairs health records data with time-to-event analyses conducted to assess the impact on graft and patient survival...
December 2, 2016: American Journal of Nephrology
https://www.readbyqxmd.com/read/27907114/rates-and-predictors-of-non-adherence-to-antiretroviral-therapy-among-hiv-positive-individuals-in-kenya-results-from-the-second-kenya-aids-indicator-survey-2012
#4
Irene N Mukui, Lucy Ng'ang'a, John Williamson, Joyce N Wamicwe, Shobha Vakil, Abraham Katana, Andrea A Kim
INTRODUCTION: Understanding the levels and associated factors of non-adherence to antiretroviral therapy (ART) is crucial in designing interventions to improve adherence and health outcomes of ART. We assessed non-adherence to ART among HIV-infected persons reporting ART use in a nationally representative survey in Kenya. METHODS: The Kenya AIDS Indicator Survey 2012 was a population-based, household survey of persons aged 18 months-64 years conducted in 2012-2013...
2016: PloS One
https://www.readbyqxmd.com/read/27906026/plasma-hiv-1-rna-viral-load-rebound-among-people-who-inject-drugs-receiving-antiretroviral-therapy-art-in-a-canadian-setting-an-ethno-epidemiological-study
#5
Will Small, M J Milloy, Ryan McNeil, Lisa Maher, Thomas Kerr
BACKGROUND: People who inject drugs (PWID) living with HIV often experience sub-optimal antiretroviral therapy (ART) treatment outcomes, including HIV plasma viral load (PVL) rebound. While previous studies have identified risk factors for PVL rebound among PWID, no study has examined the perspectives of PWID who have experienced PVL rebound episodes. We conducted an ethno-epidemiological study to investigate the circumstances surrounding the emergence of rebound episodes among PWID in Vancouver, BC, Canada...
July 25, 2016: AIDS Research and Therapy
https://www.readbyqxmd.com/read/27905987/factors-associated-with-the-first-antiretroviral-therapy-modification-in-older-hiv-1-positive-patients
#6
Justyna D Kowalska, Joanna Kubicka, Ewa Siwak, Piotr Pulik, Ewa Firląg-Burkacka, Andrzej Horban
BACKGROUND: Rates of first antiretroviral therapy (cART) modifications are high in most observational studies. The age-related differences in treatment duration and characteristics of first cART modifications remain underinvestigated. With increasing proportion of older patients in HIV population it is important to better understand age-related treatment effects. METHODS: Patients were included into this analysis, if being cART naïve at the first visit at the clinic...
January 7, 2016: AIDS Research and Therapy
https://www.readbyqxmd.com/read/27903829/long-term-adherence-to-low-sodium-diet-in-patients-with-heart-failure
#7
Misook L Chung, Linda Park, Susan K Frazier, Terry A Lennie
Although following a low-sodium diet (LSD) for heart failure (HF) has been recommended for decades, little is known about factors related to long-term patient adherence. The purposes of this study were to (a) compare sodium intake and factors affecting adherence in a long-term adherent group and in a non-adherent group and (b) examine predictors of membership in the long-term adherent group. Patients with HF (N = 74) collected 24-hr urine samples and completed the Dietary Sodium Restriction Questionnaire and the Patient Health Questionnaire-9...
November 30, 2016: Western Journal of Nursing Research
https://www.readbyqxmd.com/read/27903564/validated-adherence-scales-used-in-a-measurement-guided-medication-management-approach-to-target-and-tailor-a-medication-adherence-intervention-a-randomised-controlled-trial
#8
Thi-My-Uyen Nguyen, Adam La Caze, Neil Cottrell
OBJECTIVE: To determine if a targeted and tailored intervention based on a discussion informed by validated adherence scales will improve medication adherence. DESIGN: Prospective randomised trial. SETTING: 2 community pharmacies in Brisbane, Australia. METHODS: Patients recently initiated on a cardiovascular or oral hypoglycaemic medication within the past 4-12 weeks were recruited from two community pharmacies. Participants identified as non-adherent using the Medication Adherence Questionnaire (MAQ) were randomised into the intervention or control group...
November 30, 2016: BMJ Open
https://www.readbyqxmd.com/read/27901302/factors-associated-with-intentional-and-unintentional-non-adherence-to-adjuvant-endocrine-therapy-following-breast-cancer
#9
J Brett, D Fenlon, M Boulton, N J Hulbert-Williams, F M Walter, P Donnelly, B Lavery, A Morgan, C Morris, E Watson
Adherence to adjuvant endocrine therapy (AET) following breast cancer is known to be suboptimal despite its known efficacy in reducing recurrence and mortality. This study aims to investigate factors associated with non-adherence and inform the development of interventions to support women and promote adherence. A questionnaire survey to measure level of adherence, side effects experienced, beliefs about medicine, support received and socio-demographic details was sent to 292 women 2-4 years post breast cancer diagnosis...
November 30, 2016: European Journal of Cancer Care
https://www.readbyqxmd.com/read/27900372/application-of-the-marginal-structural-model-to-account-for-suboptimal-adherence-in-a-randomized-controlled-trial
#10
James Rochon, Manjushri Bhapkar, Carl F Pieper, William E Kraus
BACKGROUND: There is considerable interest in adjusting for suboptimal adherence in randomized controlled trials. A per-protocol analysis, for example removes individuals who fail to achieve a minimal level of adherence. One can also reassign non-adherers to the control group, censor them at the point of non-adherence, or cross them over to the control. However, there are biases inherent in each of these methods. Here, we describe an application of causal modeling to address this issue...
December 15, 2016: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/27898679/patient-reported-barriers-to-adherence-to-antiretroviral-therapy-a-systematic-review-and-meta-analysis
#11
Zara Shubber, Edward J Mills, Jean B Nachega, Rachel Vreeman, Marcelo Freitas, Peter Bock, Sabin Nsanzimana, Martina Penazzato, Tsitsi Appolo, Meg Doherty, Nathan Ford
BACKGROUND: Maintaining high levels of adherence to antiretroviral therapy (ART) is a challenge across settings and populations. Understanding the relative importance of different barriers to adherence will help inform the targeting of different interventions and future research priorities. METHODS AND FINDINGS: We searched MEDLINE via PubMed, Embase, Web of Science, and PsychINFO from 01 January 1997 to 31 March 2016 for studies reporting barriers to adherence to ART...
November 2016: PLoS Medicine
https://www.readbyqxmd.com/read/27895914/revisiting-the-internal-consistency-and-factorial-validity-of-the-8-item-morisky-medication-adherence-scale
#12
Arsène Zongo, Line Guénette, Jocelyne Moisan, Laurence Guillaumie, Sophie Lauzier, Jean-Pierre Grégoire
OBJECTIVE: To assess the internal consistency and factorial validity of the adapted French 8-item Morisky Medication Adherence Scale in assessing adherence to noninsulin antidiabetic drug treatment. STUDY DESIGN AND SETTING: In a cross-sectional web survey of individuals with type 2 diabetes of the Canadian province of Quebec, self-reported adherence to the antidiabetes drug treatment was measured using the Morisky Medication Adherence Scale-8. We assessed the internal consistency of the Morisky Medication Adherence Scale-8 with Cronbach's alpha, and factorial validity was assessed by identifying the underlying factors using exploratory factor analyses...
2016: SAGE Open Medicine
https://www.readbyqxmd.com/read/27895583/matching-adherence-interventions-to-patient-determinants-using-the-theoretical-domains-framework
#13
REVIEW
Samuel S Allemann, Robby Nieuwlaat, Bart J F van den Bemt, Kurt E Hersberger, Isabelle Arnet
Introduction: Despite much research, interventions to improve medication adherence report disappointing and inconsistent results. Tailored approaches that match interventions and patient determinants of non-adherence were seldom used in clinical trials. The presence of a multitude of theoretical frameworks and models to categorize interventions and patient determinants complicated the development of common categories shared by interventions and determinants. We retrieved potential interventions and patient determinants from published literature on medication adherence, matched them like locks and keys, and categorized them according to the Theoretical Domains Framework (TDF)...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27894911/personal-and-provider-level-factors-influence-participation-to-cervical-cancer-screening-a-retrospective-register-based-study-of-1-3-million-women-in-norway
#14
Maarit K Leinonen, Suzanne Campbell, Ole Klungsøyr, Stefan Lönnberg, Bo T Hansen, Mari Nygård
High coverage is essential for an effective screening programme. Here we present screening barriers and facilitators among 1.3 million women aged 25-69years eligible for screening within the Norwegian Cervical Cancer Screening Program (NCCSP). We defined non-adherence as no screening test in 2008-2012. We divided adherent women into those screened spontaneously, and those who had a smear after receiving a reminder from the NCCSP. Explanatory variables were extracted from several nationwide registers, and modelled by modified Poisson regression...
November 25, 2016: Preventive Medicine
https://www.readbyqxmd.com/read/27894012/depression-in-cancer-the-many-biobehavioral-pathways-driving-tumor-progression
#15
REVIEW
Beatrice Bortolato, Thomas N Hyphantis, Sara Valpione, Giulia Perini, Michael Maes, Gerwyn Morris, Marta Kubera, Cristiano A Köhler, Brisa S Fernandes, Brendon Stubbs, Nicholas Pavlidis, André F Carvalho
Major Depressive Disorder (MDD) is common among cancer patients, with prevalence rates up to four-times higher than the general population. Depression confers worse outcomes, including non-adherence to treatment and increased mortality in the oncology setting. Advances in the understanding of neurobiological underpinnings of depression have revealed shared biobehavioral mechanisms may contribute to cancer progression. Moreover, psychosocial stressors in cancer promote: (1) inflammation and oxidative/nitrosative stress; (2) a decreased immunosurveillance; and (3) a dysfunctional activation of the autonomic nervous system and of the hypothalamic-pituitaryadrenal axis...
November 16, 2016: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/27892443/medication-adherence-pattern-and-factors-affecting-adherence-in-helicobacter-pylori-eradication-therapy
#16
S Shakya Shrestha, M Bhandari, S R Thapa, R Shrestha, R Poudyal, B Purbey, R B Gurung
Background Helicobacter pylori (H. pylori) infection is the most common chronic bacterial infection worldwide affecting approximately half of the world's population. A number of screening tests as well as complex multi-drug therapies are available for the detection and treatment of H. pylori infection. However, the optimum eradication rates of H. pylori infection can only be achieved if adherence to drug therapy is higher. Therefore, it is of utmost importance to determine the factors leading to poor adherence to obtain successful treatment outcomes...
January 2016: Kathmandu University Medical Journal (KUMJ)
https://www.readbyqxmd.com/read/27892441/a-prospective-study-of-commonly-prescribed-drugs-in-the-management-of-neuropathic-pain-and-its-medication-adherence-pattern
#17
R Shrestha, P Silwal, N Basnet, S Shakya Shrestha, R Shrestha, B R Pokharel
Background Neuropathic pain is one of the common complains of patients visiting neurology and orthopedic departments in hospitals. Management of neuropathic pain is difficult and is often symptomatic rather than being curative. Adherence to medication is necessary for pain management to be effective. However, there are various factors related to patient, physician, drug regimen and other socio-economic affecting adherence. Objective To study commonly prescribed drugs in neuropathic pain management and the medication adherence pattern including its associated factors...
January 2016: Kathmandu University Medical Journal (KUMJ)
https://www.readbyqxmd.com/read/27890398/influenza-vaccination-in-people-with-type-2-diabetes-coverage-predictors-of-uptake-and-perceptions-result-of-the-madiabetes-cohort-a-7years-follow-up-study
#18
Rodrigo Jiménez-Garcia, Ana Lopez-de-Andres, Valentin Hernandez-Barrera, Paloma Gómez-Campelo, Francisco J San Andrés-Rebollo, Carmen de Burgos-Lunar, Juan Cárdenas-Valladolid, Juan Carlos Abánades-Herranz, Miguel Angel Salinero-Fort
OBJECTIVES: We aim to determine influenza vaccination uptake among people with diabetes included in the MADIABETES cohort study in order to identify predictors of uptake and to analyze reasons for adherence and non-adherence with vaccination. METHODS: Using data from the MADIABETES Study we conducted a retrospective case record form based study without controls. We included outpatients with type 2 diabetes mellitus. Information was obtained from computerized clinical records and by telephone survey...
November 24, 2016: Vaccine
https://www.readbyqxmd.com/read/27889904/how-to-screen-for-non-adherence-to-antihypertensive-therapy
#19
REVIEW
Pankaj Gupta, Prashanth Patel, Robert Horne, Heather Buchanan, Bryan Williams, Maciej Tomaszewski
The quality of assessment of non-adherence to treatment in hypertensive is poor. Within this review, we discuss the different methods used to assess adherence to blood-pressure-lowering medications in hypertension patients. Subjective reports such as physicians' perceptions are inaccurate, and questionnaires completed by patients tend to overreport adherence and show a low diagnostic specificity. Indirect objective methods such as pharmacy database records can be useful, but they are limited by the robustness of the recorded data...
December 2016: Current Hypertension Reports
https://www.readbyqxmd.com/read/27889809/reversal-of-type-2-diabetes-in-youth-who-adhere-to-a-very-low-energy-diet-a-pilot-study
#20
Megan L Gow, Louise A Baur, Nathan A Johnson, Chris T Cowell, Sarah P Garnett
AIMS/HYPOTHESIS: The aim of the study was to investigate whether a very-low-energy diet (VLED) is a feasible and acceptable treatment option for type 2 diabetes in children and adolescents, and whether adherence can lead to rapid weight loss, reversal of type 2 diabetes and reduced liver fat as seen in adult studies. METHODS: Eight participants with type 2 diabetes and obesity, aged 7-16 years, non-medicated (n = 1) or treated with metformin (n = 7) and in some cases insulin (n = 3), followed a VLED (<3360 kJ/day) for 8 weeks, then transitioned to a hypocaloric diet (∼6300 kJ/day) that they followed to 34 weeks...
November 26, 2016: Diabetologia
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