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Non-adherence

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https://www.readbyqxmd.com/read/28815689/medication-adherence-in-patients-with-apparent-resistant-hypertension-findings-from-the-sympathy-trial
#1
R L de Jager, E M van Maarseveen, M L Bots, P J Blankestijn
INTRODUCTION: Hypertension is only controlled in approximately 35% of the patients, which could be partially due to non-adherence. Recently, bioanalytical assessment of adherence to blood pressure (BP) lowering drugs has gaining interest. Our aim was to explore possible determinants of non-adherence in treatment resistant hypertension, assessed by objective screening for antihypertensive agents in serum. Secondary aim was to study the effect of adherence on the change in BP. METHODS: This project was a sub-study of SYMPATHY; an open-label randomized-controlled trial to assess the effect of renal denervation on BP six months after treatment compared to usual care in patients with resistant hypertension...
August 17, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28814330/novel-remote-electronic-medication-supply-model-for-opioid-dependent-outpatients-with-polypharmacy-first-long-term-case-study
#2
Samuel S Allemann, Kenneth M Dürsteler, Johannes Strasser, Marc Vogel, Marcel Stoeckle, Kurt E Hersberger, Isabelle Arnet
BACKGROUND: Patients with substance use disorders grow older thanks to effective treatments. Together with a high prevalence of comorbidities, psychological problems, and low social support, these patients are at high risk for medication non-adherence. Established treatment facilities face challenges to accommodate these complex patients within their setting. Electronic medication management aids (e-MMAs) might be appropriate to simultaneously monitor and improve adherence for these patients...
August 16, 2017: Harm Reduction Journal
https://www.readbyqxmd.com/read/28810401/a-dual-process-view-on-medication-adherence-the-role-of-affect
#3
Mieke Kleppe, Joyca Lacroix, Jaap Ham, Cees Midden
Medication non-adherence has been recognised as one of the major problems in health care that leads to preventable costs and hospitalisations. This study aimed to assess the role of affect in medication adherence. We propose a dual-process framework of medication adherence based on the reflective-impulsive model, which includes both cognitive and affective processes. We tested this framework in a cross-sectional study ( N = 525). The results supported this framework by illustrating the clear role of both cognitive and affective processes...
February 1, 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/28810360/habit-strength-as-a-moderator-of-the-association-between-symptoms-of-poor-mental-health-and-unintentional-non-adherence-to-oral-hypoglycemic-medication-in-adults-with-type-2-diabetes
#4
Rachel J Burns, Sonya S Deschênes, Bärbel Knäuper, Norbert Schmitz
This study tested if habit strength for taking oral hypoglycemic medication moderated the association between poor mental health symptoms (i.e. depressive symptoms, diabetes distress) and unintentional non-adherence in 790 adults with type 2 diabetes. Data were cross-sectional. A habit strength × depressive symptom interaction was observed. Depressive symptoms were negatively associated with adherence if habit was weak or of average strength; no association was observed if habit was strong. A similar interaction emerged when diabetes distress was examined...
October 1, 2016: Journal of Health Psychology
https://www.readbyqxmd.com/read/28809640/-treatment-of-displaced-patellar-fractures-with-multiple-circular-cerclage
#5
Z Tříska, J Urban, P Látal, M Kloub
PURPOSE OF THE STUDY The study aims to conduct a mid-term evaluation of results of the treatment of patellar fractures with multiple circular cerclage. MATERIAL AND METHODS The retrospective clinical study with its own group of patients who underwent surgery in our centre in the period from 2008 to 2014. The study included a total of 29 patients with displaced patellar fractures treated with multiple circular cerclage. The available radiographic documentation was assessed and the quality of perioperative reposition, fracture healing, loss of reposition and potential failure of osteosynthesis material was considered...
2017: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
https://www.readbyqxmd.com/read/28803848/disengagement-in-immigrant-groups-receiving-services-for-a-first-episode-of-psychosis
#6
Anika Maraj, Franz Veru, Laura Morrison, Ridha Joober, Ashok Malla, Srividya Iyer, Jai Shah
OBJECTIVE: Although early intervention (EI) programs for psychosis invest in clients remaining engaged in treatment, disengagement remains a concern. It is not entirely clear whether immigrants are likelier to disengage. The rates and predictors of disengagement for immigrant vis-à-vis non-immigrant clients in a Canadian EI setting were analyzed. METHOD: 297 clients were included in a time-to-event analysis with Cox Proportional Hazards regression models. Immigrant status (first- or second-generation immigrant or non-immigrant), age, gender, education, substance abuse, family contact, social and material deprivation and medication non-adherence were tested as predictors of service disengagement...
August 10, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28802672/congruence-between-patient-characteristics-and-interventions-may-partly-explain-medication-adherence-intervention-effectiveness-an-analysis-of-190-randomized-controlled-trials-from-a-cochrane-systematic-review
#7
REVIEW
Samuel S Allemann, Robby Nieuwlaat, Tamara Navarro, Brian Haynes, Kurt E Hersberger, Isabelle Arnet
BACKGROUND: Due to the negative outcomes of medication non-adherence, interventions to improve adherence have been the focus of countless studies. The congruence between adherence-related patient characteristics and interventions may partly explain the variability of effectiveness in medication adherence studies. In their latest update of a Cochrane review reporting inconsistent effects of adherence interventions, the authors offered access to their database for sub-analysis. We aimed to use this database to assess congruence between adherence-related patient characteristics and interventions and its association with intervention effects...
August 9, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28802371/how-can-we-improve-medical-adherence-to-intranasal-corticosteroids-in-children
#8
Emre Ocak, Deniz Kocaoz, Baran Acar
OBJECTIVE: To evaluate the factors which may be related to nonadherence to intranasal corticosteroids (ICS) in the treatment of allergic rhinitis (AR) in children. METHODS: A prospective study was conducted on children with AR diagnosis in a tertiary referral hospital. All participants were provided with mometasone furoate nasal sprays for 30 days after the diagnosis. Caregivers were called back when the therapy was over and completed a questionnaire about the factors that may influence the adherence to the treatment...
September 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28801402/reasons-for-non-adherence-to-cardiometabolic-medications-and-acceptability-of-an-interactive-voice-response-intervention-in-patients-with-hypertension-and-type-2-diabetes-in-primary-care-a-qualitative-study
#9
Aikaterini Kassavou, Stephen Sutton
OBJECTIVES: This study explored the reasons for patients' non-adherence to cardiometabolic medications, and tested the acceptability of the interactive voice response (IVR) as a way to address these reasons, and support patients, between primary care consultations. DESIGN, METHOD, PARTICIPANTS AND SETTING: The study included face-to-face interviews with 19 patients with hypertension and/or type 2 diabetes mellitus, selected from primary care databases, and presumed to be non-adherent...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28800510/medication-adherence-in-schizophrenia-the-role-of-insight-therapeutic-alliance-and-perceived-trauma-associated-with-psychiatric-care
#10
Arnaud Tessier, Laurent Boyer, Mathilde Husky, Franck Baylé, Pierre-Michel Llorca, David Misdrahi
Medication non adherence in schizophrenia is a major cause of relapse and hospitalization and remains for clinicians an important challenge. This study investigates the associations between insight, therapeutic alliance, perceived trauma related to psychiatric treatment and medication adherence in patients with schizophrenia. In this multicenter study, 72 patients were assessed regarding symptomatology, self-reported adherence with medication, insight, medication side-effects, therapeutic alliance and perceived trauma related to psychiatric treatment...
July 31, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28800268/asthma-management-experiences-of-australians-who-are-native-arabic-speakers
#11
Reem Alzayer, Betty Chaar, Iman Basheti, Bandana Saini
OBJECTIVE: The aim of this study was to explore the asthma management experiences of people with asthma within the Arabic-speaking community in Australia. METHODS: Semi-structured interviews guided by a schedule of questions were conducted with 25 Arabic-speaking women with asthma/carer of a child with asthma, recruited from medical practices and community centers in Melbourne, Australia. RESULTS: Twenty-five Arabic-speaking participants with asthma or caring for those with asthma were interviewed...
August 11, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28798944/diet-alcohol-use-and-colorectal-cancer-screening-among-black-church-goers
#12
Nga T Nguyen, Elaine J Savoy, Lorraine R Reitzel, Minh-Anh H Nguyen, David W Wetter, Jacqueline Reese-Smith, Lorna H McNeill
OBJECTIVES: Interventions for colorectal cancer (CRC) prevention among black adults are needed. Connections between CRC screening non-adherence and other health risk behaviors may inform intervention development. METHODS: Associations between red meat (RM) and fruit and vegetable (FV) consumption, at-risk alcohol use, and CRC ever-screening were examined using adjusted logistic regressions among 520 church-going black adults in Houston, Texas, aged >50. RESULTS: In the final adjusted model, being younger, uninsured, eating more RM and engaging in at-risk alcohol use were associated with lower likelihood of CRC ever-screening...
March 2017: Health Behavior and Policy Review
https://www.readbyqxmd.com/read/28797565/low-adherence-to-antidepressants-is-associated-with-increased-mortality-in-parkinson-disease-patients
#13
Gal Shoval, Brendon Stubbs, Ran D Balicer, Becca Feldman, Moshe Hoshen, Gil Zalsman, Roi Sagy, Eldar Hochman, Abraham Weizman, Amir Krivoy
INTRODUCTION: The purpose of this study was to evaluate the relationship between adherence to antidepressants (AD) and all-cause mortality in a population-based cohort of patients with Parkinson's Disease (PD). METHODS: From a database of more than 4 million people, 8553 patients with PD who purchased an AD at least once between the years 2008-2011 were retrospectively followed for all-cause mortality over 4-years. Adherence was measured as a ratio between dispensed and prescribed durations and was modeled as: non-adherence (<20%, n = 1566), poor (20%-50%, n = 1184), moderate (50%-80%, n = 1584), and good (>80%, n = 4219) adherence...
August 1, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28793120/functional-health-literacy-and-adherence-to-the-medication-in-older-adults-integrative-review
#14
Nidia Farias Fernandes Martins, Daiane Porto Gautério Abreu, Bárbara Tarouco da Silva, Deisa Salyse Dos Reis Cabral Semedo, Marlene Teda Pelzer, Fabiana Souza Ienczak
Objective: to characterize the national and international scientific production on the relationship of Functional Health Literacy and the adherence to the medication in older adults. Method: integrative review of literature, searching the following online databases: Scientific Electronic Library Online (SCIELO); Latin American and Caribbean Health Sciences Literature (LILACS); Medical Literature Analysis and Retrieval System Online (MEDLINE); and Cumulative Index to Nursing & Allied Health Literature (CINAHL), in June 2016...
July 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28790807/non-persistence-and-non-adherence-to-mtx-therapy-in-patients-with-rheumatoid-arthritis-a-retrospective-cohort-study-based-on-german-ra-patients
#15
Sabrina Müller, Thomas Wilke, Andreas Fuchs, Ulf Maywald, Jan-Paul Flacke, Harald Heinisch, Klaus Krüger
OBJECTIVE: This study aimed to assess the level of nonpersistence (NP) and nonadherence (NA) to methotrexate (MTX) therapy in German patients with rheumatoid arthritis (RA). MATERIALS AND METHODS: Based on German claims data, RA patients who received a MTX therapy (subgroup: treatment-naive patients) were analyzed. NP was defined as treatment gap >12 weeks. Regarding NA, it is the overall medication possession ratio (MPR) during an observational period of 12 or 24 months after therapy, and the MPR is calculated only for the periods of therapy continuation; NA was defined as MPR <80%...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28776320/cost-effectiveness-of-support-for-people-starting-a-new-medication-for-a-long-term-condition-through-community-pharmacies-an-economic-evaluation-of-the-new-medicine-service-nms-compared-with-normal-practice
#16
Rachel A Elliott, Lukasz Tanajewski, Georgios Gkountouras, Anthony J Avery, Nick Barber, Rajnikant Mehta, Matthew J Boyd, Asam Latif, Antony Chuter, Justin Waring
BACKGROUND: The English community pharmacy New Medicine Service (NMS) significantly increases patient adherence to medicines, compared with normal practice. We examined the cost effectiveness of NMS compared with normal practice by combining adherence improvement and intervention costs with the effect of increased adherence on patient outcomes and healthcare costs. METHODS: We developed Markov models for diseases targeted by the NMS (hypertension, type 2 diabetes mellitus, chronic obstructive pulmonary disease, asthma and antiplatelet regimens) to assess the impact of patients' non-adherence...
August 3, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28773099/the-impact-of-metal-ion-exposure-on-the-cellular-behavior-of-human-osteoblasts-and-pbmcs-in-vitro-analyses-of-osteolytic-processes
#17
Anika Jonitz-Heincke, Jenny Tillmann, Annett Klinder, Simone Krueger, Jan Philippe Kretzer, Paul Johan Høl, Alexander C Paulus, Rainer Bader
Osteolysis in the periprosthetic tissue can be caused by metallic wear particles and ions that can originate from implant surface corrosion. These products influence cellular behavior and stimulate the expression of proinflammatory cytokines. The purpose of this study was to evaluate the impact of CoCr29Mo6 ions on cell survival, differentiation, and cytokine expression in human osteoblasts and peripheral blood mononuclear cells (PBMCs). Thus, we exposed cells with a mixture of 200 µg/L ion solution and determined cell viability and apoptosis/necrosis...
July 3, 2017: Materials
https://www.readbyqxmd.com/read/28770561/evaluation-of-a-muscle-pump-activating-device-for-non-healing-venous-leg-ulcers
#18
Connie Harris, Rochelle Duong, Gwen Vanderheyden, Beth Byrnes, Renee Cattryse, Ava Orr, David Keast
This evaluation involves an innovative muscle pump-activating device (geko™) as an adjunctive therapy with best practices for non-healing venous leg ulcers (VLUs). Stimulating the common peroneal nerve (at the fibular head), the geko™ device creates a response that acts as foot and calf muscle pumps, increasing venous, arterial and microcirculatory flow. The aim was to evaluate and determine if the geko™ is effective in this population and if it should be added to the medical supply formulary. In all, 12 patients with 18 recalcitrant VLUs (defined as less than 30% reduction in wound size in 30 days with best practices) in two community settings in Ontario consented to the evaluation and were treated with the geko™ for up to 20 weeks...
August 2, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28768483/live-cell-calcium-imaging-of-adherent-and-non-adherent-gl261-cells-reveals-phenotype-dependent-differences-in-drug-responses
#19
Averey D Strong, Richard L Daniels
BACKGROUND: The tumor-derived GL261 cell line is used as a model for studying glioblastoma and other high-grade gliomas, and can be cultured adherently or as free-floating aggregates known as neurospheres. These different culture conditions give rise to distinct phenotypes, with increased tumorigenicity displayed by neurosphere-cultured cells. An important technique for understanding GL261 pathobiology is live cell fluorescent imaging of intracellular calcium. However, live cell imaging of GL261 neurospheres presents a technical challenge, as experimental manipulations where drugs are added to the extracellular media cause the cells to move during analysis...
August 2, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28766482/self-reported-adherence-to-capecitabine-on-xelox-treatment-as-adjuvant-therapy-for-colorectal-cancer
#20
Kazuyoshi Kawakami, Takashi Yokokawa, Kazuo Sugita, Takahito Sugisaki, Kenichi Suzuki, Mitsukuni Suenaga, Kensei Yamaguchi, Ayaka Inoue, Yoshiaki Machida, Toshiharu Yamaguchi, Toshihiro Hama
Adherence has become an important issue in modern oncology treatment. Most studies have included heterogeneous target tumor types, regimens, and therapy settings. Our study focused on capecitabine during capecitabine plus oxaliplatin (XELOX) treatment as adjuvant therapy for colorectal cancer. The main aim of this study was to evaluate real-life adherence to capecitabine and to investigate candidate factors that might decrease adherence. We studied 338 consecutive patients who received XELOX treatment between December 1, 2011 and April 30, 2015 at the Cancer Institute Hospital of the Japanese Foundation for Cancer Research...
August 1, 2017: Oncology Research
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