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https://www.readbyqxmd.com/read/29050397/the-antimyotonic-effect-of-lamotrigine-in-non-dystrophic-myotonias-a-double-blind-randomized-study
#1
Grete Andersen, Gitte Hedermann, Nanna Witting, Morten Duno, Henning Andersen, John Vissing
Mexiletine is the only drug with proven effect for treatment of non-dystrophic myotonia, but mexiletine is expensive, has limited availability and several side effects. There is therefore a need to identify other pharmacological compounds that can alleviate myotonia in non-dystrophic myotonias. Like mexiletine, lamotrigine is a sodium channel blocker, but unlike mexiletine, lamotrigine is available, inexpensive, and well tolerated. We investigated the potential of using lamotrigine for treatment of myotonia in patients with non-dystrophic myotonias...
September 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29048348/analysis-of-a-community-pharmacy-intervention-to-improve-low-adherence-rates-to-oral-diabetes-medications
#2
Jerica Singleton, Stevie Veach, Christine Catney, Matthew Witry
For patients with diabetes, suboptimal medication adherence contributes to disease progression, complications, and increased healthcare costs. Identification of, and intervention for patient-identified reasons for nonadherence are essential to improving medication adherence. This prospective, quality improvement study was conducted at an independent community pharmacy in the Mid-West United States. Patients with a proportion of days covered (PDC) for their oral antidiabetic medications of less than 80% were contacted by telephone and interviewed by a clinical pharmacist...
October 19, 2017: Pharmacy (Basel, Switzerland)
https://www.readbyqxmd.com/read/29046815/non-adherence-to-inhalational-medications-and-associated-factors-among-patients-with-asthma-in-a-referral-hospital-in-ethiopia-using-validated-tool-tai
#3
Asnakew Achaw Ayele, Henok Getachew Tegegn
BACKGROUND: Asthma is a chronic inflammatory condition of the airways that affects roughly 358 million people globally. It is a serious global health problem with an increasing prevalence worldwide. Most people affected are in low- and middle-income countries including Ethiopia. The association between non -adherence and poor disease control is clearly stated in different literatures. The main objective of the present study was to assess self-reported non- adherence level and to identify the potential factors associated with non-adherence...
2017: Asthma research and practice
https://www.readbyqxmd.com/read/29043922/barriers-and-facilitators-to-dispensing-of-intranasal-naloxone-by-pharmacists
#4
Ludmila N Bakhireva, Adriana Bautista, Sandra Cano, Shikhar Shrestha, Amy M Bachyrycz, Theresa H Cruz
BACKGROUND: While misuse of prescription opioids has reached epidemic proportions, pharmacy-based preventive services to combat this epidemic are limited. The aims of this study were to identify barriers and facilitators to the dispensing of intranasal naloxone (INN) by pharmacists in New Mexico. METHODS: For this mixed methods study, a qualitative component (focus group) informed the development of a quantitative component (electronic survey) distributed to all pharmacists registered with the New Mexico Board of Pharmacy and practicing in the state...
October 18, 2017: Substance Abuse
https://www.readbyqxmd.com/read/29026250/thousands-of-new-oral-health-educators
#5
(no author information available yet)
Oral health promotion in the community pharmacy: an evaluation of a pilot oral health promotion intervention.
October 13, 2017: British Dental Journal
https://www.readbyqxmd.com/read/29025141/how-is-it-best-to-deliver-care-in-acute-medical-units-a-systematic-review
#6
L E M Reid, A J F Crookshanks, M C Jones, Z J Morrison, N I Lone, C J Weir
The majority of medical patients presenting to hospital in the UK are cared for in acute medical units (AMUs). Such units are also increasingly present internationally. Care delivery varies across units: this review aims to examine the evidence for how best to deliver AMU care.Six electronic databases and grey literature were searched. Inclusion criteria comprised interventions applied to undifferentiated patients in AMU settings. All studies were quality assessed. A narrative approach was undertaken.Nine studies, all conducted in the UK or Ireland, evaluated 1...
August 4, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29025066/supply-and-demand-application-of-lean-six-sigma-methods-to-improve-drug-round-efficiency-and-release-nursing-time
#7
Maríosa Kieran, Mary Cleary, Aoife De Brún, Aileen Igoe
Objective: To improve efficiency, reduce interruptions and reduce the time taken to complete oral drug rounds. Design: Lean Six Sigma methods were applied to improve drug round efficiency using a pre- and post-intervention design. Setting: A 20-bed orthopaedic ward in a large teaching hospital in Ireland. Participants: Pharmacy, nursing and quality improvement staff. Intervention(s): A multifaceted intervention was designed which included changes in processes related to drug trolley organization and drug supply planning...
August 19, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29022823/impact-of-a-medication-reconciliation-program-on-cardiac-surgery-patients
#8
Abdulrazaq S Al-Jazairi, Lujain Khalid Al-Suhaibani, Rayd A Al-Mehizia, Salma Al-Khani, Glyn Lewis, Edward B De Vol, Elias Juan Saad
Background Cardiac surgery patients are at high risk of medication errors. Resumption of home medications reduces the significance and number of medication errors. This could be achieved by implementing a medication reconciliation program. Patients and Methods Patients were eligible for inclusion in this prospective study if they were admitted, transferred, and/or discharged under cardiac surgery team care from September 2015 to March 2016. The primary outcome was the number and proportion of unintentional medication discrepancies...
January 1, 2017: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/29020476/adulteration-and-counterfeiting-of-online-nutraceutical-formulations-in-the-united-states-time-for-intervention
#9
Mohamed Ismail Nounou, Yamin Ko, Nada A Helal, Jeremy F Boltz
Global prevalence of nutraceuticals is noticeably high. The American market is flooded with nutraceuticals claiming to be of natural origin and sold with a therapeutic claim by major online retail stores such as Amazon and eBay. The objective of this commentary is to highlight the possible problems of online-sold nutraceuticals in the United States with respect to claim, adulterants, and safety. Furthermore, there is a lack of strict regulatory laws governing the sales, manufacturing, marketing, and label claims of nutraceutical formulations currently sold in the U...
October 11, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29018588/do-chain-pharmacies-perform-better-than-independent-pharmacies-evidence-from-a-standardised-patient-study-of-the-management-of-childhood-diarrhoea-and-suspected-tuberculosis-in-urban-india
#10
Rosalind Miller, Catherine Goodman
INTRODUCTION: Pharmacies and drug stores are frequently patients' first point of care in many low-income and middle-income countries, but their practice is often poor. Pharmacy retailing in India has traditionally been dominated by local, individually owned shops, but recent years have seen the growth of pharmacy chains. In theory, lower-powered profit incentives and self-regulation to preserve brand identity may lead to higher quality in chain stores. In practice, this has been little studied...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29017755/self-medication-and-non-prescription-drug-counseling-illustrating-profession-uncertainty-within-turkish-pharmacy-practice
#11
Afonso Miguel Cavaco, Bilge Sozen-Sahne, Elif Ulutas-Deniz, Selen Yegenoglu
BACKGROUND: Recommending effective minor ailment treatments and using non-prescription or over-the-counter (OTC) medicines is a pharmacist's duty. Although common in most European countries, self-medication counseling practices may differ from country to country. OBJECTIVES: This study explored Turkish community pharmacists' attitudes concerning the present self-medication market, professional responsibilities toward patients' self-care, and the usefulness of e-learning for patients' counseling education...
September 29, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/28994315/first-line-treatment-disruption-among-post-menopausal-women-with-hr-her2-metastatic-breast-cancer-a-retrospective-us-claims-study
#12
Derek H Tang, Nanxin Li, Ella X Du, Miranda Peeples, Lihao Chu, Jipan Xie, Victoria Barghout
OBJECTIVE: This study assessed disruption of first-line treatments initiated after the approval of the first CDK 4/6 inhibitor, palbociclib, among postmenopausal women with HR+/HER2- metastatic breast cancer (mBC) in the United States. METHODS: Postmenopausal women with HR+/HER2- mBC who initiated first-line endocrine therapy or chemotherapy (index therapy) between 3(rd) February 2015 (palbociclib approval date) and 29(th) February 2016 (end of data) were identified from the Symphony SourceLx database...
October 10, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28988193/using-the-esexual-health-clinic-to-access-chlamydia-treatment-and-care-via-the-internet-a-qualitative-interview-study
#13
Catherine R H Aicken, Lorna J Sutcliffe, Jo Gibbs, Laura J Tickle, Kate Hone, Emma M Harding-Esch, Catherine H Mercer, Pam Sonnenberg, S Tariq Sadiq, Claudia S Estcourt, Maryam Shahmanesh
OBJECTIVE: We developed the eSexual Health Clinic (eSHC), an innovative, complex clinical and public health intervention, embedded within a specialist sexual health service. Patients with genital chlamydia access their results online and are offered medical management via an automated online clinical consultation, leading to antibiotic collection from community pharmacy. A telephone helpline, staffed by Sexual Health Advisers, is available to support patients and direct them to conventional services if appropriate...
October 7, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28987074/combination-of-rheum-ribes-and-metformin-against-diabetes-thermal-hyperalgesia-and-tactile-allodynia-in-a-mice-model
#14
Karim Raafat, Abdalla El-Lakany
Context • The prevalence of diabetes mellitus (DM) is increasing. Because of its progressive nature, therapeutic shifts and combinations are often required to reduce the risk of glucose toxicity and avoid serious side effects. To treat DM and its related complications, a combination therapy may offer a promising remedy to counteract those issues. Objectives • The study was established to evaluate the phytochemical content of a standardized aqueous extract of Rheum ribes (RR) and to determine the antidiabetic, antihyperalgesic, and antimechanical allodynic effects of 50 mg/kg of RR alone, 25 mg/kg of metformin (MTF) alone, and a combination of the 2 substances (MTF+RR) in mice with alloxan-induced diabetes...
October 2, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28986515/improving-admission-medication-reconciliation-with-pharmacists-or-pharmacy-technicians-in-the-emergency-department-a-randomised-controlled-trial
#15
Joshua M Pevnick, Caroline Nguyen, Cynthia A Jackevicius, Katherine A Palmer, Rita Shane, Galen Cook-Wiens, Andre Rogatko, Mackenzie Bear, Olga Rosen, David Seki, Brian Doyle, Anish Desai, Douglas S Bell
BACKGROUND: Admission medication history (AMH) errors frequently cause medication order errors and patient harm. OBJECTIVE: To quantify AMH error reduction achieved when pharmacy staff obtain AMHs before admission medication orders (AMO) are placed. METHODS: This was a three-arm randomised controlled trial of 306 inpatients. In one intervention arm, pharmacists, and in the second intervention arm, pharmacy technicians, obtained initial AMHs prior to admission...
October 6, 2017: BMJ Quality & Safety
https://www.readbyqxmd.com/read/28979513/paediatric-electronic-infusion-calculator-an-intervention-to-eliminate-infusion-errors-in-paediatric-critical-care
#16
Aishwarya Venkataraman, Emily Siu, Kalaimaran Sadasivam
INTRODUCTION: Medication errors, including infusion prescription errors are a major public health concern, especially in paediatric patients. There is some evidence that electronic or web-based calculators could minimise these errors. AIMS: To evaluate the impact of an electronic infusion calculator on the frequency of infusion errors in the Paediatric Critical Care Unit of The Royal London Hospital, London, United Kingdom. METHOD: We devised an electronic infusion calculator that calculates the appropriate concentration, rate and dose for the selected medication based on the recorded weight and age of the child and then prints into a valid prescription chart...
November 2016: J Intensive Care Soc
https://www.readbyqxmd.com/read/28975485/introducing-clinical-pharmacy-services-to-cardiovascular-clinics-at-a-university-hospital-in-northern-cyprus
#17
Haider Al-Baghdadi, Çiğdem Koca Al-Baghdadi, Abdikarim Abdi, Onur Gültekin, Arijana Meštrović, Rumeysa Demirdamar, Barçın Özcem, Bilgen Başgut
Background Clinical pharmacists are the primary source of scientifically valid information and advice on the safe, rational, and cost-effective use of medications. However, ward-based clinical pharmacy services are not well optimized in Northern Cyprus. Objective Ward based clinical pharmacy services were introduced and evaluated in cardiovascular clinics. Setting Cardiology and cardiovascular surgery departments in a tertiary university hospital. Methods A prospective interventional study introduced and documented clinical pharmacy services for 120 days...
October 3, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28970614/impact-of-standardized-simulated-patients-on-first-year-pharmacy-students-knowledge-retention-of-insulin-injection-technique-and-counseling-skills
#18
Riley Bowers, Robert Tunney, Kim Kelly, Beth Mills, Katie Trotta, C Neil Wheeless, Richard Drew
Objective. To compare pre- and post-intervention test scores assessing insulin injection technique and counseling skills among P1 students with (intervention) or without (control) simulated patients, and to compare counseling checklist and knowledge retention test scores between groups. Methods. This study utilized cluster randomization. In addition to traditional instruction, the intervention group counseled a simulated patient on the use of insulin using the teach-back method. Test score changes from baseline were analyzed via two-sample t-test...
August 2017: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28970612/predicting-student-success-using-in-program-monitoring
#19
Alexandra B Ferrante, Joshua Lambert, Markos Leggas, Esther P Black
Objective. To determine whether admissions data alone adequately predicts student success in the first-year doctor of pharmacy (PharmD) curriculum or whether academic monitoring and intervention has greater value toward successful completion of first-year coursework. Methods. A systematic evaluation of the literature assessing student success was performed to ascertain historical evidence of student success metrics. We then retrospectively analyzed internal admissions data and first-year outcomes for our pharmacy classes of 2016-2019 using available data...
August 2017: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28970464/validating-the-modified-drug-adherence-work-up-m-draw-tool-to-identify-and-address-barriers-to-medication-adherence
#20
Sun Lee, Yuna H Bae, Marcia Worley, Anandi Law
Barriers to medication adherence stem from multiple factors. An effective and convenient tool is needed to identify these barriers so that clinicians can provide a tailored, patient-centered consultation with patients. The Modified Drug Adherence Work-up Tool (M-DRAW) was developed as a 13-item checklist questionnaire to identify barriers to medication adherence. The response scale was a 4-point Likert scale of frequency of occurrence (1 = never to 4 = often). The checklist was accompanied by a GUIDE that provided corresponding motivational interview-based intervention strategies for each identified barrier...
September 8, 2017: Pharmacy (Basel, Switzerland)
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