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Cornelia Wiegand, Andrea Völpel, Andrea Ewald, Markko Remesch, Jan Kuever, Janine Bauer, Stefanie Griesheim, Carolin Hauser, Julian Thielmann, Silke Tonndorf-Martini, Bernd W Sigusch, Jürgen Weisser, Ralf Wyrwa, Peter Elsner, Uta-Christina Hipler, Martin Roth, Carolin Dewald, Claudia Lüdecke-Beyer, Jörg Bossert
Bactericidal materials gained interest in the health care sector as they are capable of preventing material surfaces from microbial colonization and subsequent spread of infections. However, commercialization of antimicrobial materials requires proof of their efficacy, which is usually done using in vitro methods. The ISO 22196 standard (Japanese test method JIS Z 2801) is a method for measuring the antibacterial activity of daily goods. As it was found reliable for testing the biocidal activity of antimicrobially active materials and surface coatings most of the laboratories participating in this study used this protocol...
2018: PloS One
Keith G Avin, Julian A Vallejo, Neal X Chen, Kun Wang, Chad D Touchberry, Marco Brotto, Sarah L Dallas, Sharon M Moe, Michael J Wacker
Skeletal muscle dysfunction accompanies the clinical disorders of chronic kidney disease (CKD) and hereditary hypophosphatemic rickets. In both disorders fibroblast growth factor 23 (FGF23), a bone-derived hormone regulating phosphate and vitamin D metabolism, becomes chronically elevated. FGF23 has been shown to play a direct role in cardiac muscle dysfunction; however, it is unknown whether FGF23 signaling can also directly induce skeletal muscle dysfunction. We found expression of potential FGF23 receptors ( Fgfr1-4) and α-Klotho in muscles of two animal models (CD-1 and Cy/+ rat, a naturally occurring rat model of Chronic Kidney Disease-Mineral Bone Disorder) as well as C2 C12 myoblasts and myotubes...
March 20, 2018: American Journal of Physiology. Endocrinology and Metabolism
José Ignacio Fernández-Vigo, Lucía De-Pablo-Gómez-de-Liaño, Bachar Kudsieh, Cristina Fernández-Vigo, José Ángel Fernández-Vigo, Julián García-Feijóo
PURPOSE: To describe the presence of anterior chamber angle (ACA) tissue as an incidental optical coherence tomography (OCT) finding in healthy children. METHODS: For this cross-sectional study, we reviewed Fourier domain OCT images obtained in 422 children as candidates for inclusion in a prior study who visited our clinic for a routine vision test. The presence of angle tissue was assessed in the nasal and temporal quadrants. On tomographies showing angle tissue, several measurements were made including ACA width and trabecular meshwork (TM) length and size...
March 19, 2018: Journal of Glaucoma
Marian Christoph Neidert, Daniel Johannes Kowalewski, Manuela Silginer, Konstantina Kapolou, Linus Backert, Lena Katharina Freudenmann, Janet Kerstin Peper, Ana Marcu, Sophie Shih-Yüng Wang, Juliane Sarah Walz, Fabian Wolpert, Hans-Georg Rammensee, Reinhard Henschler, Katrin Lamszus, Manfred Westphal, Patrick Roth, Luca Regli, Stefan Stevanović, Michael Weller, Günter Eisele
Glioblastoma is the most frequent malignant primary brain tumor. In a hierarchical tumor model, glioblastoma stem-like cells (GSC) play a major role in tumor initiation and maintenance as well as in therapy resistance and recurrence. Thus, targeting this cellular subset may be key to effective immunotherapy. Here, we present a mass spectrometry-based analysis of HLA-presented peptidomes of GSC and glioblastoma patient specimens. Based on the analysis of patient samples (n = 9) and GSC (n = 3), we performed comparative HLA peptidome profiling against a dataset of normal human tissues...
March 20, 2018: Acta Neuropathologica
Sarah J Brislin, Christopher J Patrick, Herta Flor, Frauke Nees, Angela Heinrich, Laura E Drislane, James R Yancey, Tobias Banaschewski, Arun L W Bokde, Uli Bromberg, Christian Büchel, Erin Burke Quinlan, Sylvane Desrivières, Vincent Frouin, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Dimitri Papadopoulos Orfanos, Luise Poustka, Juliane H Fröhner, Michael N Smolka, Henrik Walter, Robert Whelan, Patricia Conrod, Argyris Stringaris, Maren Struve, Betteke van Noort, Yvonne Grimmer, Tahmine Fadai, Gunter Schumann, Jens Foell
Trait disinhibition, a clinical-liability construct, has well-established correlates in the diagnostic, self-rating, task-behavioral, and brain potential response domains. Recently, studies have begun to test for neuroimaging correlates of this liability factor, but more work of this type using larger data sets is needed to clarify its brain bases. The current study details the development and validation of a scale measure of trait disinhibition composed of questionnaire items available in the IMAGEN project, a large-scale longitudinal study of factors contributing to substance abuse that includes clinical interview, self-report personality, task-behavioral, neuroimaging, and genomic measures...
March 1, 2018: Assessment
Maria Laura Santoru, Cristina Piras, Antonio Murgia, Vanessa Palmas, Tania Camboni, Sonia Liggi, Ivan Ibba, Maria Antonia Lai, Sandro Orrù, Sylvain Blois, Anna Lisa Loizedda, Julian Leether Griffin, Paolo Usai, Pierluigi Caboni, Luigi Atzori, Aldo Manzin
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
March 19, 2018: Scientific Reports
Julián Esteban Sáez, Cristian Arredondo, Carlos Rivera, María Estela Andrés
CoREST family of transcriptional corepressors regulates gene expression and cell fate determination during development. CoREST corepressors recruit with different affinity the histone demethylase LSD1 (KDM1A) and the deacetylases HDAC1/2 to repress with variable strength the expression of target genes. CoREST protein levels are differentially regulated during cell fate decisions and in mature tissues. However, regulatory mechanisms of CoREST corepressors at the protein level have not been studied. Here, we report that CoREST (CoREST1, RCOR1) and its homologs CoREST2 (RCOR2) and CoREST3 (RCOR3) interact with PIASγ, a SUMO-E3 ligase...
March 19, 2018: Biochemical Journal
Martin Lorenz Eisinger, Laiyin Nie, Aline Ricarda Dörrbaum, Julian David Langer, Hartmut Michel
Multidrug resistance (MDR) in bacterial pathogens has become a severe threat to public health. Membrane transporters of the multidrug and toxic compound extrusion (MATE) family contribute critically to MDR, making them promising drug targets. Despite recent advances, structures in different conformations and the mechanistic details of their antiport cycle are still elusive. Here we studied NorM_PS, a representative MATE transporter from Pseudomonas stutzeri, using biochemical assays in combination with hydrogen/deuterium exchange-mass spectrometry (HDX-MS)...
March 16, 2018: Journal of Molecular Biology
Corey Joseph, Marie Garrubba, Julian A Smith, Angela Melder
Pulmonary artery catheters (PACs) were introduced in 1970. Since then, their use has steadily increased. However, there have been questions raised regarding their efficacy for multiple clinical scenarios. The purpose of this systematic review was to determine the safety and effectiveness of routine use of PACs post cardiac surgery on mortality, complications, days in intensive care unit, days in hospital, and costs in patients undergoing cardiac surgery, or patients who end up in an intensive care unit. METHODS: Medline, All EBM, Embase and Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases were searched using predetermined search terms...
February 21, 2018: Heart, Lung & Circulation
Julian Nader, Nina Król, Martin Pfeffer, Valerie Ohlendorf, Marco Marklewitz, Christian Drosten, Sandra Junglen, Anna Obiegala
BACKGROUND: Ticks are important carriers of many different zoonotic pathogens. To date, there are many studies about ticks and tick-borne pathogens (TBP), but only a few were carried out in Bulgaria. The present study intends to detect the prevalence of tick-borne bacteria and parasites occurring at the Black Sea in Bulgaria to evaluate the zoonotic potential of the tick-borne pathogens transmitted by ticks in this area. METHODS: In total, cDNA from 1541 ticks (Dermacentor spp...
March 20, 2018: Parasites & Vectors
Víctor J Rincón, Francisco C Páez, Julián Sánchez-Hermosilla
During pesticide application, operators are exposed to chemical products. Dermal exposure has been reported as the principal means of exposure for growers. In the present work, potential dermal exposure (PDE) has been assessed when using new low-cost equipment (a knapsack with a vertical spray boom) and compared to a hand-held spray lance, which is the equipment most widely used by growers in greenhouses. Two sprayers were used, a hand-held spray lance with four twin flat-fan nozzles and a knapsack fitted out with a vertical spray boom containing 3 pairs of twin flat-fan nozzles...
March 2, 2018: Science of the Total Environment
Kathrin R Blume, Juliane Racz, Marcel Franz, Caroline Dietrich, Christian Puta, Reinhard Friedel, Gunther O Hofmann, Wolfgang H R Miltner, Thomas Weiss
A comprehensive functional recovery is one of the criteria for successful replantation of an amputated limb. Functionality of a replanted limb is strongly dependent on its regained sensibility. In previous studies concerning the sensibility of replanted limbs, only a few somatosensory submodalities were examined in small samples. The purpose of the present study is to provide a full pattern of somatosensory symptoms following replantation. Quantitative Sensory Testing (QST) was carried out according to a standardized protocol in a sample of 15 patients who underwent replantation of their upper limb proximal to the radiocarpal joint (macroreplantation)...
March 15, 2018: Pain
Xing Chen, Detlef Wolf, Juliane Siebourg-Polster, Christian Czech, Ulrike Bonati, Dirk Fischer, Omar Khwaja, Martin Strahm
Progressive and irreversible muscle atrophy characterizes Spinal Muscular Atrophy (SMA) and other similar muscle disorder diseases. Objective assessment of muscle functions is an essential and important, although challenging, prerequisite for successful clinical trials. Current clinical rating scales restrain the movement abnormalities to certain predefined coarse-grained individual items. The Kinect 3-D sensor has emerged as a low-cost and portable motion sensing technology used to capture and track people's movement in many medical and research fields...
February 12, 2018: Journal of Visualized Experiments: JoVE
Christopher Blattman, Julian C Jamison, Margaret Sheridan
We show that a number of noncognitive skills and preferences, including patience and identity, are malleable in adults, and that investments in them reduce crime and violence. We recruited criminally engaged men and randomized one-half to eight weeks of cognitive behavioral therapy designed to foster self-regulation, patience, and a noncriminal identity and lifestyle. We also randomized $200 grants. Cash alone and therapy alone initially reduced crime and violence, but effects dissipated over time. When cash followed therapy, crime and violence decreased dramatically for at least a year...
April 2017: American Economic Review
Mini Kamboj, Teresa Childers, Jessica Sugalski, Donna Antonelli, Juliane Bingener-Casey, Jamie Cannon, Karie Cluff, Kimberly A Davis, E Patchen Dellinger, Sean C Dowdy, Kim Duncan, Julie Fedderson, Robert Glasgow, Bruce Hall, Marilyn Hirsch, Matthew Hutter, Lisa Kimbro, Boris Kuvshinoff, Martin Makary, Melanie Morris, Sharon Nehring, Sonia Ramamoorthy, Rebekah Scott, Mindy Sovel, Vivian Strong, Ashley Webster, Elizabeth Wick, Julio Garcia Aguilar, Robert Carlson, Kent Sepkowitz
BACKGROUND Surgical site infections (SSIs) following colorectal surgery (CRS) are among the most common healthcare-associated infections (HAIs). Reduction in colorectal SSI rates is an important goal for surgical quality improvement. OBJECTIVE To examine rates of SSI in patients with and without cancer and to identify potential predictors of SSI risk following CRS DESIGN American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) data files for 2011-2013 from a sample of 12 National Comprehensive Cancer Network (NCCN) member institutions were combined...
March 19, 2018: Infection Control and Hospital Epidemiology
Melissa Rochon, Julian We Jarman, Joseph Gabriel, Lisa Butcher, Carlos Morais, Martin Still, Ishtiaq Ahmed, Mario Petrou, Richard Trimlett, Anthony DeSouza, Rashmi Yadav, Shahzad G Raja
Background: Previously, we reported that the Brompton Harefield Infection Score (BHIS) accurately predicts surgical site infection (SSI) after coronary artery bypass grafting (CABG). The BHIS was developed using two-centre data and stratifies SSI risk into three groups based on female gender, diabetes or HbA1c > 7.5%, body mass index ≥ 35, left ventricular ejection fraction < 45% and emergency surgery. The purpose of this study was to prospectively evaluate BHIS internally as well as externally...
March 2018: Journal of Infection Prevention
Julian Conrad, Rainer Boegle, Matthias Ertl, Thomas Brandt, Marianne Dieterich
Objective: Vestibular signals are involved in higher cortical functions like spatial orientation and its disorders. Vestibular dysfunction contributes, for example, to spatial neglect which can be transiently improved by caloric stimulation. The exact roles and mechanisms of the vestibular and visual systems for the recovery of neglect are not yet known. Methods: Resting-state functional connectivity (fc) magnetic resonance imaging was recorded in a patient with hemispatial neglect during the acute phase and after recovery 6 months later following a right middle cerebral artery infarction before and after caloric vestibular stimulation...
2018: Frontiers in Neurology
Désirée E S Larenas Linnemann, Margarita Fernández Vega, Jorge Agustín Luna Pech, Jimena Villaverde Rosas, José Antonio Ortega Martell, Blanca Estela Del Río Navarro, María Del Carmen Cano Salas, Jade Romero Lombard, Erika Del Carmen López Estrada, Monica Rodriguez-González, José Luis Mayorga Butrón, Jorge Salas Hernández, Juan Carlos Vázquez García, Ignacio Ortiz Aldana, Mario Humberto Vargas Becerra, Martín Bedolla Barajas, Noel Rodríguez Pérez, Ambrocio Aguilar Aranda, Carlos Adrián Jiménez González, Carlos García Bolaños, Claudia Garrido Galindo, David Alejandro Mendoza Hernández, Enrique Mendoza López, Gerardo López Pérez, Guillermo Hideo Wakida Kuzonoki, Héctor Hernán Ruiz Gutiérrez, Héctor León Molina, Héctor Martínez de la Lanza, Héctor Stone Aguilar, Javier Gómez Vera, Jorge Olvera Salinas, José Joel Oyoqui Flores, José Luis Gálvez Romero, José Santos Lozano Saenz, Juan Ignacio Salgado Gama, Marcos Alejandro Jiménez Chobillon, Martha Angélica García Avilés, Martha Patricia Guinto Balanzar, Miguel Alejandro Medina Ávalos, Robert Camargo Angeles, Rogelio García Torrentera, Saraí Toral Freyre, Gabriel Montes Narvaez, Héctor Solorio Gómez, Juan Rosas Peña, Sergio Jesús Romero Tapia, Adela Reyes Herrera, Francisco Cuevas Schacht, Joaquín Esquer Flores, José Antonio Sacre Hazouri, Lorenzo Compean Martínez, Pablo Julián Medina Sánchez, Sergio Garza Salinas, Carlos Baez Loyola, Iraís Romero Alvarado, José Luis Miguel Reyes, Laura Elizabeth Huerta Espinosa, Manuel Ángel Correa Flores, Ricardo Castro Martínez
No abstract text is available yet for this article.
March 15, 2018: Annals of Allergy, Asthma & Immunology
Patrick Küry, Avindra Nath, Alain Créange, Antonina Dolei, Patrice Marche, Julian Gold, Gavin Giovannoni, Hans-Peter Hartung, Hervé Perron
The causes of multiple sclerosis and amyotrophic lateral sclerosis have long remained elusive. A new category of pathogenic components, normally dormant within human genomes, has been identified: human endogenous retroviruses (HERVs). These represent ∼8% of the human genome, and environmental factors have reproducibly been shown to trigger their expression. The resulting production of envelope (Env) proteins from HERV-W and HERV-K appears to engage pathophysiological pathways leading to the pathognomonic features of MS and ALS, respectively...
March 15, 2018: Trends in Molecular Medicine
Pete Buth, Benoit de Gryse, Sean Healy, Vincent Hoedt, Tara Newell, Giovanni Pintaldi, Hernan Del Valle, Julian C Sheather, Sidney Wong
Humanitarian organisations often work alongside those responsible for serious wrongdoing. In these circumstances, accusations of moral complicity are sometimes levelled at decision makers. These accusations can carry a strong if unfocused moral charge and are frequently the source of significant moral unease. In this paper, we explore the meaning and usefulness of complicity and its relation to moral accountability. We also examine the impact of concerns about complicity on the motivation of humanitarian staff and the risk that complicity may lead to a retreat into moral narcissism...
March 17, 2018: Journal of Medical Ethics
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