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https://www.readbyqxmd.com/read/29352980/effect-of-two-cooling-protocols-on-the-post-thaw-characteristics-of-iberian-ibex-sperms
#1
Milagros C Esteso, Adolfo Toledano-Díaz, Cristina Castaño, Jorgea Pradiee, Antonio Lopez-Sebastián, Julián Santiago-Moreno
The rate at which lethal intracellular ice forms during sperm cryopreservation is highly dependent on the cooling protocol. The present work compares two cooling protocols for use with Iberian ibex (Capra pyrenaica) sperm by assessing the effects on the motility, viability, and size of frozen-thawed sperm cells. Ejaculates, obtained from six adult ibex males via transrectal, ultrasound-guided massage of the accessory sex glands plus electroejaculation if necessary, were cooled via either 1) Protocol 1 (decelerating cooling), involving cooling in liquid nitrogen vapor from 5 °C to -35 °C (40 °C/min), from -35 °C to -65 °C (17 °C/min), and then from -65 °C to -85 °C (3 °C/min); or 2) Protocol 2 (accelerating cooling) involving cooling in a biological freezer from 5 °C to -5 °C (4 °C/min), from -5 °C to -110 °C (25 °C/min), and then from -110 °C to -140 °C (35 °C/min)...
January 15, 2018: Cryobiology
https://www.readbyqxmd.com/read/29352380/integrated-prediction-of-lesion-specific-ischaemia-from-quantitative-coronary-ct-angiography-using-machine-learning-a-multicentre-study
#2
Damini Dey, Sara Gaur, Kristian A Ovrehus, Piotr J Slomka, Julian Betancur, Markus Goeller, Michaela M Hell, Heidi Gransar, Daniel S Berman, Stephan Achenbach, Hans Erik Botker, Jesper Moller Jensen, Jens Flensted Lassen, Bjarne Linde Norgaard
OBJECTIVES: We aimed to investigate if lesion-specific ischaemia by invasive fractional flow reserve (FFR) can be predicted by an integrated machine learning (ML) ischaemia risk score from quantitative plaque measures from coronary computed tomography angiography (CTA). METHODS: In a multicentre trial of 254 patients, CTA and invasive coronary angiography were performed, with FFR in 484 vessels. CTA data sets were analysed by semi-automated software to quantify stenosis and non-calcified (NCP), low-density NCP (LD-NCP, < 30 HU), calcified and total plaque volumes, contrast density difference (CDD, maximum difference in luminal attenuation per unit area) and plaque length...
January 19, 2018: European Radiology
https://www.readbyqxmd.com/read/29352114/binding-of-nufip2-to-roquin-promotes-recognition-and-regulation-of-icos-mrna
#3
Nina Rehage, Elena Davydova, Christine Conrad, Gesine Behrens, Andreas Maiser, Jenny E Stehklein, Sven Brenner, Juliane Klein, Aicha Jeridi, Anne Hoffmann, Eunhae Lee, Umberto Dianzani, Rob Willemsen, Regina Feederle, Kristin Reiche, Jörg Hackermüller, Heinrich Leonhardt, Sonia Sharma, Dierk Niessing, Vigo Heissmeyer
The ubiquitously expressed RNA-binding proteins Roquin-1 and Roquin-2 are essential for appropriate immune cell function and postnatal survival of mice. Roquin proteins repress target mRNAs by recognizing secondary structures in their 3'-UTRs and by inducing mRNA decay. However, it is unknown if other cellular proteins contribute to target control. To identify cofactors of Roquin, we used RNA interference to screen ~1500 genes involved in RNA-binding or mRNA degradation, and identified NUFIP2 as a cofactor of Roquin-induced mRNA decay...
January 19, 2018: Nature Communications
https://www.readbyqxmd.com/read/29352060/the-100-most-cited-articles-in-the-endovascular-management-of-intracranial-aneurysms
#4
Julian Maingard, Kevin Phan, Yifan Ren, Hong Kuan Kok, Vincent Thijs, Joshua A Hirsch, Michael J Lee, Ronil V Chandra, Duncan Mark Brooks, Hamed Asadi
INTRODUCTION: Endovascular interventions for intracranial aneurysms have evolved substantially over the past several decades. A citation rank list is used to measure the scientific and/or clinical impact of an article. Our objective was to identify and analyze the characteristics of the 100 most cited articles in the field of endovascular therapy for intracranial aneurysms. METHODS: We performed a retrospective bibliometric analysis between July and August 2017...
January 19, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29351916/pathways-impacted-by-genomic-alterations-in-pulmonary-carcinoid-tumors
#5
Michael K Asiedu, Charles F Thomas, Jie Dong, Sandra C Schulte Tomaszek, Prasidda Khadka, Zhifu Sun, Farhad Kosari, Jin Jen, Julian R Molina, George Vasmatzis, Rui Kuang, Marie Christine Aubry, Ping Yang, Dennis A Wigle
PURPOSE: Pulmonary carcinoid tumors account for up to 5% of all lung malignancies in adults, comprise 30% of all carcinoid malignancies, and are defined histologically as typical carcinoid (TC) and atypical carcinoid (AC) tumors. The role of specific genomic alterations in the pathogenesis of pulmonary carcinoid tumors remains poorly understood. We sought to identify genomic alterations and pathways that are deregulated in these tumors to find novel therapeutic targets for pulmonary carcinoid tumors...
January 19, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29351707/-crying-retina-sign
#6
Juliane Handtke, Maria Waizel, Margarita G Todorova
No abstract text is available yet for this article.
January 19, 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29351165/the-relationship-between-maximum-pull-up-repetitions-and-first-repetition-mean-concentric-velocity
#7
George K Beckham, Joshua J Olmeda, Alexandra J Flores, Julian A Echeverry, Alexus F Campos, Steven B Kim
Mean concentric velocity (MCV) of exercise execution has been used by strength and conditioning professionals to improve exercise technique, provide accurate feedback, and predict exercise one repetition maximum. There is still limited research on velocity based training and currently only one research study on the pull-up exercise. The primary purpose of this research was to determine if the maximum number of pull-ups an individual can perform can be predicted by the MCV of a single pull-up repetition. Forty-nine healthy men and women were recruited who reported they could do at least two pull-ups...
January 17, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29351040/respiratory-polysomnographic-findings-in-patients-treated-primarily-for-unilateral-cleft-lip-and-palate
#8
Davi Sandes Sobral, Gustavo Juliane Faller, Marcus Vinícius Martins Collares
Cleft lip and palate (CLP) is the most common congenital craniofacial abnormality. Obstructive sleep apnea syndrome (OSAS) is a highly prevalent but underdiagnosed disease and is frequently associated with craniofacial anomalies. There are few studies describing the sleep breathing pattern of children with CLP. This study sought to characterize the respiratory profile of 23 children with unilateral cleft lip and palate, aged 7-12 years, who had undergone cleft lip and nasal repair at age 3-4 months and palatoplasty at 12-15 months, with a particular focus on evaluating the presence of OSAS in children with CLP...
February 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29350339/emerging-insights-into-the-esophageal-microbiome
#9
REVIEW
Michael May, Julian A Abrams
PURPOSE OF REVIEW: Analysis of the esophageal microbiome remains a relatively new field of research, and most studies to date have focused on characterizing the esophageal microbiome in states of health and disease. Microbiome alterations have been implicated in the pathogenesis of inflammatory and neoplastic conditions in the colon and elsewhere in the gastrointestinal tract. The epidemiology of various esophageal conditions including Barrett's esophagus (BE), esophageal adenocarcinoma (EAC), esophageal squamous cell carcinoma (ESCC), and eosinophilic esophagitis (EoE) point to the microbiome as a potential co-factor in disease pathogenesis, and the possibility exists that these microbiome alterations could contribute directly to the inflammatory environments necessary for the carcinogenesis or atopy involved in these conditions...
January 19, 2018: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/29349753/expensive-care-resource-based-thresholds-for-potentially-inappropriate-treatment-in-intensive-care
#10
Dominic Wilkinson, Stavros Petrou, Julian Savulescu
In intensive care, disputes sometimes arise when patients or surrogates strongly desire treatment, yet health professionals regard it as potentially inappropriate. While professional guidelines confirm that physicians are not always obliged to provide requested treatment, determining when treatment would be inappropriate is extremely challenging. One potential reason for refusing to provide a desired and potentially beneficial treatment is because (within the setting of limited resources) this would harm other patients...
January 18, 2018: Monash Bioethics Review
https://www.readbyqxmd.com/read/29349505/embracing-your-emotions-affective-state-impacts-lateralisation-of-human-embraces
#11
Julian Packheiser, Noemi Rook, Zeynep Dursun, Janne Mesenhöller, Alrescha Wenglorz, Onur Güntürkün, Sebastian Ocklenburg
Humans are highly social animals that show a wide variety of verbal and non-verbal behaviours to communicate social intent. One of the most frequently used non-verbal social behaviours is embracing, commonly used as an expression of love and affection. However, it can also occur in a large variety of social situations entailing negative (fear or sadness) or neutral emotionality (formal greetings). Embracing is also experienced from birth onwards in mother-infant interactions and is thus accompanying human social interaction across the whole lifespan...
January 18, 2018: Psychological Research
https://www.readbyqxmd.com/read/29348138/development-and-validation-of-outcome-prediction-models-for-aneurysmal-subarachnoid-haemorrhage-the-sahit-multinational-cohort-study
#12
Blessing N R Jaja, Gustavo Saposnik, Hester F Lingsma, Erin Macdonald, Kevin E Thorpe, Muhammed Mamdani, Ewout W Steyerberg, Andrew Molyneux, Airton Leonardo de Oliveira Manoel, Bawarjan Schatlo, Daniel Hanggi, David Hasan, George K C Wong, Nima Etminan, Hitoshi Fukuda, James Torner, Karl L Schaller, Jose I Suarez, Martin N Stienen, Mervyn D I Vergouwen, Gabriel J E Rinkel, Julian Spears, Michael D Cusimano, Michael Todd, Peter Le Roux, Peter Kirkpatrick, John Pickard, Walter M van den Bergh, Gordon Murray, S Claiborne Johnston, Sen Yamagata, Stephan Mayer, Tom A Schweizer, R Loch Macdonald
OBJECTIVE: To develop and validate a set of practical prediction tools that reliably estimate the outcome of subarachnoid haemorrhage from ruptured intracranial aneurysms (SAH). DESIGN: Cohort study with logistic regression analysis to combine predictors and treatment modality. SETTING: Subarachnoid Haemorrhage International Trialists' (SAHIT) data repository, including randomised clinical trials, prospective observational studies, and hospital registries...
January 18, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29348130/setd1a-protects-hscs-from-activation-induced-functional-decline-in-vivo
#13
Kathrin Arndt, Andrea Kranz, Juliane Fohgrub, Adrien Jolly, Anita S Bledau, Michela Di Virgilio, Mathias Lesche, Andreas Dahl, Thomas Höfer, A Francis Stewart, Claudia Waskow
The regenerative capacity of hematopoietic stem cells (HSCs) is limited by the accumulation of DNA damage. Conditional mutagenesis of the histone 3 lysine 4 (H3K4) methyltransferase, Setd1a, revealed that it is required for the expression of DNA damage recognition and repair pathways in HSCs. Specific deletion of Setd1a in adult long-term (LT)-HSCs is compatible with adult life and has little effect on the maintenance of phenotypic LT-HSCs in the bone marrow. However, SETD1A-deficient LT-HSCs lose their transcriptional cellular identity accompanied by loss of their proliferative capacity and stem cell function under replicative stress in situ and after transplantation...
January 18, 2018: Blood
https://www.readbyqxmd.com/read/29347880/functions-of-utopia-how-utopian-thinking-motivates-societal-engagement
#14
Julian W Fernando, Nicholas Burden, Adam Ferguson, Léan V O'Brien, Madeline Judge, Yoshihisa Kashima
Images of ideal societies, utopias, are all around us; yet, little is known of how utopian visions affect ordinary people's engagement with their societies. As goals for society, utopias may elicit processes of collective self-regulation, in which citizens are critical of, or take action to change, the societies they live in. In three studies, we investigated the psychological function of utopian thinking. In Study 1, measured utopianism was correlated with the activation of three utopian functions: change, critique, and compensation...
January 1, 2018: Personality & Social Psychology Bulletin
https://www.readbyqxmd.com/read/29347453/tricriticality-in-the-q-neighbor-ising-model-on-a-partially-duplex-clique
#15
Anna Chmiel, Julian Sienkiewicz, Katarzyna Sznajd-Weron
We analyze a modified kinetic Ising model, a so-called q-neighbor Ising model, with Metropolis dynamics [Phys. Rev. E 92, 052105 (2015)PLEEE81539-375510.1103/PhysRevE.92.052105] on a duplex clique and a partially duplex clique. In the q-neighbor Ising model each spin interacts only with q spins randomly chosen from its whole neighborhood. In the case of a duplex clique the change of a spin is allowed only if both levels simultaneously induce this change. Due to the mean-field-like nature of the model we are able to derive the analytic form of transition probabilities and solve the corresponding master equation...
December 2017: Physical Review. E
https://www.readbyqxmd.com/read/29346580/smoking-sex-and-non-small-cell-lung-cancer-steroid-hormone-receptors-in-tumor-tissue-s0424
#16
Ting-Yuan David Cheng, Amy K Darke, Mary W Redman, Gary R Zirpoli, Warren Davis, Rochelle Payne Ondracek, Wiam Bshara, Angela R Omilian, Robert Kratzke, Mary E Reid, Julian R Molina, Jill M Kolesar, Yuhchyau Chen, Robert M MacRae, James Moon, Philip Mack, David R Gandara, Karen Kelly, Regina M Santella, Kathy S Albain, Christine B Ambrosone
Background: To what extent steroid hormones contribute to lung cancer in male and female never smokers and smokers is unclear. We examined expression of hormone receptors in lung tumors by sex and smoking. Methods: Patients with primary non-small cell lung cancer were recruited into an Intergroup study in the United States and Canada, led by SWOG (S0424). Tumors from 813 cases (450 women and 363 men) were assayed using immunohistochemistry for estrogen receptor (ER)-α, ER-β, progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2)...
January 13, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29346133/dexmedetomidine-impairs-diaphragm-function-and-increases-oxidative-stress-but-does-not-aggravate-diaphragmatic-atrophy-in-mechanically-ventilated-rats
#17
Thomas Breuer, Christian Bleilevens, Rolf Rossaint, Gernot Marx, Julian Gehrenkemper, Henning Dierksen, Antoine Delpierre, Joachim Weis, Ghislaine Gayan-Ramirez, Christian S Bruells
BACKGROUND: Anesthetics in ventilated patients are critical as any cofactor hampering diaphragmatic function may have a negative impact on the weaning progress and therefore on patients' mortality. Dexmedetomidine may display antioxidant and antiproteolytic properties, but it also reduced glucose uptake by the muscle, which may impair diaphragm force production. This study tested the hypothesis that dexmedetomidine could inhibit ventilator-induced diaphragmatic dysfunction. METHODS: Twenty-four rats were separated into three groups (n = 8/group)...
January 18, 2018: Anesthesiology
https://www.readbyqxmd.com/read/29345956/measuring-three-dimensional-strain-and-structural-defects-in-a-single-ingaas-nanowire-using-coherent-x-ray-multi-angle-bragg-projection-ptychography
#18
Megan O Hill, Irene Calvo-Almazan, Mark Allain, Martin Holt, Andrew Ulvestad, Julian Treu, Gregor Koblmueller, Chunyi Huang, Xiaojing Huang, Hanfei Yan, E Nazarestski, Yong S Chu, G Brian Stephenson, Virginie Chamard, Lincoln Lauhon, Stephan O Hruszkewycz
III-As nanowires are candidates for near infrared light emitters and detectors that can be directly integrated onto silicon. However, nanoscale to microscale variations in structure, composition, and strain within a given nanowire, as well as variations between nanowires, pose challenges to correlating microstructure with device performance. In this work, we utilize coherent nano-focused x-rays to characterize stacking defects and strain in a single InGaAs nanowire supported on Si. By reconstructing diffraction patterns from the 2-1-10 Bragg peak, we show that the lattice orientation varies along the length of the wire, while the strain field along the cross-section is largely unaffected, leaving the band structure unperturbed...
January 18, 2018: Nano Letters
https://www.readbyqxmd.com/read/29345706/tuning-the-nucleophilicity-of-electron-rich-diborane-4-compounds-with-bridging-guanidinate-substituents-by-substitution
#19
Julian Horn, Anna Widera, Sebastian Litters, Elisabeth Kaifer, Hans-Jörg Himmel
Diborane(4) compounds are versatile reagents in synthetic chemistry. Generally, diboranes(4) with sp2-hybridized boron atoms react as electrophiles. By contrast, the chemistry of nucleophilic diborane(4) compounds with two sp3-hybridized boron atoms is very much underdeveloped. In this work, we systematically vary the substituents of electron-rich diborane(4) compounds with bridging guanidinate substituents. In this way, five new diboranes are synthesized and fully characterized. Using quantum chemical computations, we show that the electronic properties and reactivity of these compounds can be rationally varied by the choice of substituents...
January 18, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29345461/a-combined-iron-hydroxytriazole-dual-catalytic-system-for-site-selective-oxidation-adjacent-to-azaheterocycles
#20
Julian C Cooper, Chaosheng Luo, Ryohei Kameyama, Jeffrey F Van Humbeck
This report details a new method for site-selective methylene oxidation adjacent to azaheterocycles. A dual catalysis approach, utilizing both an iron Lewis acid and an organic hydroxylamine catalyst proved highly effective. We demonstrate that this method provides complimentary selectivity to other know catalytic approaches and represents an improvement over current heterocycle-selective reactions that rely on stoichiometric activation.
January 18, 2018: Journal of the American Chemical Society
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