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https://www.readbyqxmd.com/read/29456355/role-of-yoga-in-management-of-substance-use-disorders-a-narrative-review
#1
REVIEW
Pooja Patnaik Kuppili, Arpit Parmar, Ankit Gupta, Yatan Pal Singh Balhara
Substance use disorders are comparable to chronic medical illnesses and have a chronic relapsing course. Despite being significant contributors to morbidity and mortality, limited treatment options exist. The current narrative review was aimed at providing an overview of yoga therapy in substance-use disorders and discuss the relevant methodological issues. Articles published in English language till May 2017 indexed with PubMed, PubMed central, and Google Scholar were searched using search terms "Yoga," "Substance use," "Drug dependence," "Nicotine," "Tobacco," "Alcohol," "Opioids," "Cannabis," "Cocaine," "Stimulants," "Sedative hypnotics," "Inhalants," and "Hallucinogens" for inclusion in the review...
January 2018: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29450250/association-between-drug-use-and-urban-violence-data-from-the-ii-brazilian-national-alcohol-and-drugs-survey-bnads
#2
Renata Rigacci Abdalla, Luciana Massaro, André de Queiroz Constantino Miguel, Ronaldo Laranjeira, Raul Caetano, Clarice S Madruga
Objective: To investigate the association of alcohol and cocaine use with urban violence (both as victim and as perpetrator) in a representative sample of the Brazilian population. Method: The Second Brazilian Alcohol and Drugs Survey (II BNADS) interviewed 4607 individuals aged 14 years and older from the Brazilian household population including an oversample of 1157 adolescents (14 to 18 years old). The survey gathered information on alcohol, tobacco and illegal substances use as well as on risk factors for abuse and dependence, behaviors associated with the use of substances and the possible consequences, as urban violence indicators...
June 2018: Addictive Behaviors Reports
https://www.readbyqxmd.com/read/29431453/relations-between-facets-and-personality-domains-with-impulsivity-new-evidence-using-the-dsm-5-section-iii-framework-in-patients-with-substance-use-disorders
#3
Enrique Moraleda-Barreno, Carmen Díaz-Batanero, Pedro Juan Pérez-Moreno, Jesús Gómez-Bujedo, Oscar M Lozano
Section III of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition proposes an alternative diagnostic model for personality disorders based on the identification of pathological personality facets. Despite the existing evidence for the relationship between personality disorders and impulsivity in patients with substance use disorders, no study has yet been conducted within this framework. Thus, using a sample of 110 patients with substance use disorders, the present work aims to (a) analyze the relationship between the different personality facets and domains evaluated by the Personality Inventory for the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (PID-5) and impulsivity and (b) explore the relationships between severity of dependency and personality facets and dimensions of impulsivity...
February 12, 2018: Personality Disorders
https://www.readbyqxmd.com/read/29430793/medial-habenula-cholinergic-signaling-regulates-cocaine-associated-relapse-like-behavior
#4
Alberto J López, Yousheng Jia, André O White, Janine L Kwapis, Monica Espinoza, Philip Hwang, Rianne Campbell, Yasaman Alaghband, Om Chitnis, Dina P Matheos, Gary Lynch, Marcelo A Wood
Propensity to relapse, even following long periods of abstinence, is a key feature in substance use disorders. Relapse and relapse-like behaviors are known to be induced, in part, by re-exposure to drug-associated cues. Yet, while many critical nodes in the neural circuitry contributing to relapse have been identified and studied, a full description of the networks driving reinstatement of drug-seeking behaviors is lacking. One area that may provide further insight to the mechanisms of relapse is the habenula complex, an epithalamic region composed of lateral and medial (MHb) substructures, each with unique cell and target populations...
February 12, 2018: Addiction Biology
https://www.readbyqxmd.com/read/29426260/gambling-and-its-clinical-correlates-in-university-students
#5
Jon E Grant, Katherine Lust, Gary A Christenson, Sarah A Redden, Samuel R Chamberlain
OBJECTIVE: This study sought to examine the prevalence of gambling disorder (GD) in a university sample and its associated physical and mental health correlates. METHODS: A 156-item anonymous online survey was distributed via random email generation to a sample of 9449 university students. Current use of alcohol and drugs, psychological and physical status and academic performance were assessed, along with questionnaire-based measures of impulsivity and compulsivity...
February 9, 2018: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/29423710/intravenous-cocaine-self-administration-in-a-panel-of-inbred-mouse-strains-differing-in-acute-locomotor-sensitivity-to-cocaine
#6
Amanda J Roberts, Linzy Casal, Salvador Huitron-Resendiz, Trey Thompson, Lisa M Tarantino
RATIONALE: Initial sensitivity to drugs of abuse often predicts subsequent use and abuse, but this relationship is not always observed in human studies. Moreover, studies examining the relationship between initial locomotor sensitivity and the rewarding and reinforcing effects of drugs in animal models have also been equivocal. Understanding the relationship between initial drug effects and propensity to continue use, potentially resulting in the development of a substance use disorder, may help to identify key targets for prevention and treatment...
January 29, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29423197/the-potential-role-of-complements-in-cocaine-induced-thrombotic-microangiopathy
#7
Adriana Dejman, Seyed Navid Alavi, David B Thomas, Alexandra Stefanovic, Arif Asif, Ali Nayer
Thrombotic microangiopathy (TMA) is a rare disorder characterized by microvascular injury and occlusion resulting in tissue ischemia and dysfunction. TMA occurs in a variety of settings including cocaine use. Although cocaine is widely used in the United States, cocaine-associated TMA is only rarely reported. Therefore, other factors may predispose cocaine users to the development of TMA. Emerging evidence indicates that cocaine activates complements. Therefore, complement activation may contribute to the development of cocaine-induced TMA...
February 2018: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29420772/purchased-behavioral-health-care-received-by-military-health-system-beneficiaries-in-civilian-medical-facilities-2000-2014
#8
Nikki R Wooten, Jordan A Brittingham, Ronald O Pitner, Abbas S Tavakoli, Diana D Jeffery, K Sue Haddock
Introduction: Behavioral health conditions are a significant concern for the U.S. military and the Military Health System (MHS) because of decreased military readiness and increased health care utilization. Although MHS beneficiaries receive direct care in military treatment facilities, a disproportionate majority of behavioral health treatment is purchased care received in civilian facilities. Yet, limited evidence exists about purchased behavioral health care received by MHS beneficiaries...
February 6, 2018: Military Medicine
https://www.readbyqxmd.com/read/29407687/cognitive-deficits-in-individuals-with-methamphetamine-use-disorder-a-meta-analysis
#9
REVIEW
Stéphane Potvin, Julie Pelletier, Stéphanie Grot, Catherine Hébert, Alastair Barr, Tania Lecomte
BACKGROUND: Methamphetamine has long been considered as a neurotoxic substance causing cognitive deficits. Recently, however, the magnitude and the clinical significance of the cognitive effects associated with methamphetamine use disorder (MUD) have been debated. To help clarify this controversy, we performed a meta-analysis of the cognitive deficits associated with MUD. METHODS: A literature search yielded 44 studies that assessed cognitive dysfunction in 1592 subjects with MUD and 1820 healthy controls...
January 30, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29406581/crf2-receptor-deficiency-eliminates-social-behaviour-deficits-and-vulnerability-induced-by-cocaine
#10
Nadège Morisot, Romain Monier, Catherine Le Moine, Mark J Millan, Angelo Contarino
BACKGROUND AND PURPOSE: Poor social behaviour and vulnerability to stress are major clinical features of stimulant use disorders. The corticotropin-releasing factor (CRF) system mediates stress responses and might underlie substance use disorders; however, its implication in social impairment induced by stimulant substances remains unknown. CRF signalling is mediated by two receptor types, CRF1 and CRF2 . The present study investigated the role for the CRF2 receptor in social behaviour deficits, vulnerability to stress and related brain alterations induced by cocaine administration and withdrawal...
February 6, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29405461/tranquilizer-misuse-among-active-cocaine-users-predictors-of-initiation
#11
Élise Roy, Nelson Arruda, Didier Jutras-Aswad, Djamal Berbiche, Rossio Motta-Ochoa, Julie Bruneau
INTRODUCTION AND AIMS: Tranquilizer use is associated with negative health outcomes among people who use drugs. This paper aims to estimate the incidence rate (initiation) and identify predictors of tranquilizer misuse (TM) among cocaine users. DESIGN AND METHODS: A prospective cohort study was conducted in Montreal, Canada. Interviewer-administered questionnaires were carried out at 3-month intervals. Initiation was defined as misusing a tranquilizer for the first time during follow-up...
February 6, 2018: Drug and Alcohol Review
https://www.readbyqxmd.com/read/29397534/chronic-methylphenidate-alters-tonic-and-phasic-glutamate-signaling-in-the-frontal-cortex-of-a-freely-moving-rat-model-of-adhd
#12
Erin M Miller, Jorge E Quintero, Francois Pomerleau, Peter Huettl, Greg A Gerhardt, Paul E A Glaser
Glutamate dysfunction has been implicated in a number of substance of abuse studies, including cocaine and methamphetamine. Moreover, in attention-deficit/hyperactivity disorder (ADHD), it has been discovered that when the initiation of stimulant treatment occurs during adolescence, there is an increased risk of developing a substance use disorder later in life. The spontaneously hypertensive rat (SHR) serves as a phenotype for ADHD and studies have found increased cocaine self-administration in adult SHRs when treated with the stimulant methylphenidate (MPH) during adolescence...
February 3, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29391802/adhd-and-lifestyle-habits-in-czech-adults-a-national-sample
#13
Simon Weissenberger, Radek Ptacek, Martina Vnukova, Jiri Raboch, Martina Klicperova-Baker, Lucie Domkarova, Michal Goetz
Background: Adult attention-deficit/hyperactivity disorder (ADHD) has been added as a diagnosis to the Diagnostic and Statistical Manual of Mental Disorders version 5 (DSM5) in 2013, thus making ADHD, which has been classically known as a childhood disorder, a life-long disorder. Those suffering from the condition show very specific behavioral traits, which manifest as lifestyle habits; they also show comorbidities that can be the symptoms and/or consequences of certain lifestyles. Materials and methods: The targeted population was adults aged 18-65 years...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29389167/adolescent-d-amphetamine-exposure-enhances-the-acquisition-of-cocaine-self-administration-in-male-and-female-rats
#14
Ryan T Lacy, Hannah K Schorsch, Bridget P Austin
Diagnosis and treatment of attention-deficit/hyperactivity disorder (ADHD) has risen drastically over the past 20 years in the United States and abroad. Amphetamine-based prescription stimulants are the most prescribed treatment for ADHD and the diversion of these drugs has also increased. Reports indicate 61% of individuals with an ADHD medication prescription have sold or shared their medication. Exposure to prescription stimulants, especially for those without an ADHD diagnosis, may increase susceptibility to drugs of abuse...
February 2018: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29383683/disruption-of-a2ar-d2r-heteroreceptor-complexes-after-a2ar-transmembrane-5-peptide-administration-enhances-cocaine-self-administration-in-rats
#15
Dasiel O Borroto-Escuela, Karolina Wydra, Xiang Li, David Rodriguez, Jens Carlsson, Joanna Jastrzębska, Malgorzata Filip, Kjell Fuxe
Antagonistic allosteric A2AR-D2R receptor-receptor interactions in heteroreceptor complexes counteract cocaine self-administration and cocaine seeking in rats as seen in biochemical and behavioral experiments. It was shown that the human A2AR transmembrane five (TM5) was part of the interface of the human A2AR-D2R receptor heteromer. In the current paper, the rat A2AR synthetic TM5 (synthTM5) peptide disrupts the A2AR-D2R heteroreceptor complex in HEK293 cells as shown by the bioluminescence resonance energy transfer method...
January 30, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29374304/differences-in-trait-impulsivity-do-not-bias-the-response-to-pharmacological-drug-challenge-in-the-rat-five-choice-serial-reaction-time-task
#16
Rebecca L Barlow, Jeffrey W Dalley, Anton Pekcec
RATIONALE: Maladaptive impulsivity is symptomatic of several neuropsychiatric disorders including schizophrenia, attention-deficit hyperactivity disorder (ADHD), and substance abuse disorders; paradigms designed to assess the underlying neurobiology of this behavior are essential for the discovery of novel therapeutic agents. Various models may be used to assess impulsivity as measured by the five-choice serial reaction time task (5-CSRTT), including variable inter-trial interval (ITI) sessions, the selection of extreme high and low impulsivity phenotypes from a large outbred population of rats, as well as pharmacological challenges...
January 26, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29370197/changes-in-opiate-and-stimulant-use-through-10-years-the-role-of-contextual-factors-mental-health-disorders-and-psychosocial-factors-in-a-prospective-sud-treatment-cohort-study
#17
Grethe Lauritzen, Trond Nordfjærn
AIM: To examine temporal changes in opiate and stimulant use among patients in substance abuse treatment over a ten-year observation period and to explore the role of contextual factors, mental health disorders and psychosocial factors on these changes. METHODS: A cohort of 481 patients was prospectively interviewed at admission to treatment and after 1, 2, 7 and 10 years. The sample was recruited from 20 facilities in the Greater Oslo region, Norway. RESULTS: The majority of patients were poly-drug users and 80% had used both opiates and stimulants the last 30 days prior to treatment admission...
2018: PloS One
https://www.readbyqxmd.com/read/29369040/testing-genetic-and-environmental-associations-between-personality-disorders-and-cocaine-use-a-population-based-twin-study
#18
Nathan A Gillespie, Steven H Aggen, Amanda E Gentry, Michael C Neale, Gun P Knudsen, Robert F Krueger, Susan C South, Nikolai Czajkowski, Ragnar Nesvåg, Eivind Ystrom, Tom H Rosenström, Fartein A Torvik, Ted Reichborn-Kjennerud, Kenneth S Kendler
Until now, data have not been available to elucidate the genetic and environmental sources of comorbidity between all 10 DSM-IV personality disorders (PDs) and cocaine use. Our aim was to determine which PD traits are linked phenotypically and genetically to cocaine use. Cross-sectional data were obtained in a face-to-face interview between 1999 and 2004. Subjects were 1,419 twins (µage = 28.2 years, range = 19-36) from the Norwegian Institute of Public Health Twin Panel, with complete lifetime cocaine use and criteria for all 10 DSM-IV PDs...
February 2018: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/29364455/case-for-diagnosis-palate-perforation-due-to-cocaine-use
#19
Graciela Fernández Blanco, Maria Cecilia Madeo, Mariana Martínez, María Emilia Vázquez
We report a 42-year-old cocaine addicted female patient referred for evaluation of hard palate ulceration resulting in oro-sinus communication with difficulties in swallowing and phonation, an rhino-sinusitis. Acrylic and removable silicone prosthesis was prescribed to relieve severe functional disorders. It is essential that the patient permanently abandons cocaine use to perform surgical reconstruction.
November 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29360862/independent-associations-and-effect-modification-between-lifetime-substance-use-and-recent-mood-disorder-diagnosis-with-household-food-insecurity
#20
Karen M Davison, Cliff Holloway, Lovedeep Gondara, Anne S Hatcher
Poor mental health and substance use are associated with food insecurity, however, their potential combined effects have not been studied. This study explored independent associations and effect modification between lifetime substance use and mood disorder in relation to food insecurity. Poisson regression analysis of data from British Columbia respondents (n = 13,450; 12 years+) in the 2007/08 Canadian Community Health Survey was conducted. Measures included The Household Food Security Survey Module (7.3% food insecure), recent diagnosis of a mood disorder (self-reported; 9...
2018: PloS One
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