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Cocaine use disorder

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https://www.readbyqxmd.com/read/29661657/reprint-of-the-effect-of-n-acetylcysteine-and-working-memory-training-on-cocaine-use-craving-and-inhibition-in-regular-cocaine-users-correspondence-of-lab-assessments-and-ecological-momentary-assessment
#1
Mieke H J Schulte, Reinout W Wiers, Wouter J Boendermaker, Anna E Goudriaan, Wim van den Brink, Denise S van Deursen, Malte Friese, Emily Brede, Andrew J Waters
INTRODUCTION: Effective treatment for cocaine use disorder should dampen hypersensitive cue-induced motivational processes and/or strengthen executive control. Using a randomized, double-blind, placebo-controlled intervention, the primary aim of this study was to investigate the effect of N-Acetylcysteine (NAC) and working memory (WM)-training to reduce cocaine use and craving and to improve inhibition assessed in the laboratory and during Ecological Momentary Assessment (EMA). The second aim was to examine correspondence between laboratory and EMA data...
March 26, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29653350/relevance-of-treated-cocaine-users-retrospective-memory-of-first-cocaine-use
#2
Emily Karsinti, Kristel Piani, El Hedi Zerdazi, Uwe Maskos, Philippe Faure, Lucia Romo, Frank Bellivier, Georges Brousse, Jean Pierre Lépine, Vanessa Bloch, Florence Vorspan
Little is known regarding between-subject variability in the subjective effects of first cocaine use. This study retrospectively assesses the subjective effects of first cocaine use in 160 current treatment-seeking cocaine use disorder patients. Subjective effects of first cocaine use were evaluated with an ad-hoc questionnaire used for cannabis effects. A principal component analysis (PCA) was performed, with resulting factors correlated with clinical variables (α = 0.05). Four factors emerged in the PCA, namely Anxiety (accounting for 21...
March 29, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29651923/identification-of-domestic-violence-service-needs-among-child-welfare-involved-parents-with-substance-use-disorders-a-gender-stratified-analysis
#3
Bryan G Victor, Stella M Resko, Joseph P Ryan, Brian E Perron
The current study examined the prevalence and associations of a need for domestic violence services among child welfare-involved mothers and fathers with substance use disorders. Data were drawn from 2,231 child welfare-involved parents in Illinois with an identified substance use disorder. Approximately 42% of mothers and 33% of fathers with a substance use disorder had a concurrent need for domestic violence services. The sample was stratified by gender and logistic regression models were fit to determine the adjusted odds of an identified need for domestic violence services...
April 1, 2018: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29651507/efficacy-and-side-effects-of-baclofen-and-the-novel-gaba-b-receptor-positive-allosteric-modulator-cmppe-in-animal-models-for-alcohol-and-cocaine-addiction
#4
Valentina Vengeliene, Tatiane T Takahashi, Olga A Dravolina, Irina Belozertseva, Edwin Zvartau, Anton Y Bespalov, Rainer Spanagel
RATIONALE: Preclinical studies suggest that the GABAB receptor is a potential target for treatment of substance use disorders. However, recent clinical trials report adverse effects in patients treated with the GABAB receptor agonist baclofen and even question efficacy. How can the discrepancy between preclinical and clinical findings be explained? OBJECTIVE: To test efficacy and adverse effects of baclofen and the novel GABAB positive allosteric modulator (PAM) CMPPE in rat addiction models, which were developed in accordance with DSM...
April 12, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29627821/global-scientific-production-on-illicit-drug-addiction-a-two-decade-analysis
#5
Malahat Khalili, Afarin Rahimi-Movaghar, Behrang Shadloo, Ramin Mojtabai, Karl Mann, Masoumeh Amin-Esmaeili
AIMS: Addiction science has made great progress in the past decades. We conducted a scientometric study in order to quantify the number of publications and the growth rate globally, regionally, and at country levels. METHODS: In October 2015, we searched the Scopus database using the general keywords of addiction or drug-use disorders combined with specific terms regarding 4 groups of illicit drugs - cannabis, opioids, cocaine, and other stimulants or hallucinogens...
April 6, 2018: European Addiction Research
https://www.readbyqxmd.com/read/29620897/design-synthesis-and-characterization-of-4-undecylpiperidine-2-carboxamides-as-positive-allosteric-modulators-of-the-serotonin-5-ht-5-ht2c-receptor
#6
Christopher T Wild, Joanna M Miszkiel, Eric A Wold, Claudia A Soto, Chunyong Ding, Rachel M Hartley, Mark Andrew White, Noelle C Anastasio, Kathryn A Cunningham, Jia Zhou
An impaired signaling capacity of the serotonin (5-HT) 5-HT2C receptor (5-HT2CR) has been implicated in the neurobehavioral processes that promote relapse vulnerability in cocaine use disorder (CUD). Restoration of the diminished 5-HT2CR signaling through positive allosteric modulation presents a novel therapeutic approach. Various new molecules with the 4-alkylpiperidine-2-carboxamide scaffold were designed, synthesized, and pharmacologically evaluated, leading to the discovery of several 5-HT2CR positive allosteric modulators (PAMs)...
April 5, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29615935/transcranial-magnetic-stimulation-of-medial-prefrontal-and-cingulate-cortices-reduces-cocaine-self-administration-a-pilot-study
#7
Diana Martinez, Nina Urban, Alex Grassetti, Dinissa Chang, Mei-Chen Hu, Abraham Zangen, Frances R Levin, Richard Foltin, Edward V Nunes
Background: Previous studies have shown that repetitive transcranial magnetic stimulation (rTMS) to the dorsolateral prefrontal cortex may serve as a potential treatment for cocaine use disorder (CUD), which remains a public health problem that is refractory to treatment. The goal of this pilot study was to investigate the effect of rTMS on cocaine self-administration in the laboratory. In the self-administration sessions, CUD participants chose between cocaine and an alternative reinforcer (money) in order to directly measure cocaine-seeking behavior...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29608132/mental-health-and-substance-use-disorder-comorbidity-among-methamphetamine-using-men-who-have-sex-with-men
#8
Jesse B Fletcher, Dallas Swendeman, Cathy J Reback
Men who have sex with men (MSM) exhibit elevated rates of mental health and substance use disorder relative to their non-MSM male counterparts. Methamphetamine use in particular has been associated with both neuronal damage and mental health disorders among MSM, and this study reports on the prevalence and comorbidity of DSM-5 mental health and substance use disorders in a sample of methamphetamine-using MSM. From March 2014 through January 2015, 286 methamphetamine-using MSM enrolled in a study to reduce methamphetamine use and sexual risk behaviors...
April 2, 2018: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/29608131/do-patients-with-different-psychiatric-disorders-show-altered-social-decision-making-a-systematic-review-of-ultimatum-game-experiments-in-clinical-populations
#9
Barbara Hinterbuchinger, Alexander Kaltenboeck, Josef Severin Baumgartner, Nilufar Mossaheb, Fabian Friedrich
BACKGROUND: Impairments in social functioning are a common feature of psychiatric disorders. Game paradigms pose a unique way for studying how people make decisions in interpersonal contexts. In the last decade, researchers have started to use these paradigms to study social decision-making in patients with psychiatric disorders. PURPOSE: The aim of this systematic literature review is to summarise the currently available evidence on the behaviour of patients with psychiatric disorders in the commonly used Ultimatum Game (UG)...
April 2, 2018: Cognitive Neuropsychiatry
https://www.readbyqxmd.com/read/29604294/the-effect-of-n-acetylcysteine-or-bupropion-on-methamphetamine-self-administration-and-methamphetamine-triggered-reinstatement-of-female-rats
#10
Sergios Charntikov, Steven T Pittenger, Cindy M Pudiak, Rick A Bevins
N-acetylcysteine and bupropion are two promising candidate medications for treatment of substance use disorder. The effects of N-acetylcysteine or bupropion on methamphetamine self-administration of female rats are not well understood. To fill this gap, this study assessed the effects of N-acetylcysteine (0, 30, 60, or 120 mg/kg) and bupropion (0, 10, 30, and 60 mg/kg) on methamphetamine self-administration of female rats across the natural estrous cycle. Following a completed dose-response curve, responding for methamphetamine self-administration was extinguished and the effects of N-acetylcysteine or bupropion on methamphetamine-triggered reinstatement was evaluated in separate experiments...
March 28, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29593581/enhanced-amygdala-striatal-functional-connectivity-during-the-processing-of-cocaine-cues-in-male-cocaine-users-with-a-history-of-childhood-trauma
#11
Anne Marije Kaag, Liesbeth Reneman, Judith Homberg, Wim van den Brink, Guido A van Wingen
Background and aims: Childhood trauma is associated with increased levels of anxiety later in life, an increased risk for the development of substance use disorders, and neurodevelopmental abnormalities in the amygdala and frontostriatal circuitry. The aim of this study was to investigate the (neurobiological) link among childhood trauma, state anxiety, and amygdala-frontostriatal activity in response to cocaine cues in regular cocaine users. Methods: In this study, we included 59 non-treatment seeking regular cocaine users and 58 non-drug using controls...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29577965/bisphenol-a-induced-changes-in-the-enteric-nervous-system-of-the-porcine-duodenum
#12
Kamila Szymanska, Slawomir Gonkowski
Bisphenol A (BPA) is an organic compound from the phenolic group commonly used for the production of plastics. The use of BPA in food and drinking water containers carries a significant risk to human health since BPA can be washed out and enter consumables. BPA entering the human body with food shows a multi-directional effect and causes disorders in the functioning of many systems and organs. There is no current knowledge about the effects of BPA on the enteric nervous system. The purpose of the present study was to verify the influence of BPA on tolerable daily intake (TDI) dose (0...
March 22, 2018: Neurotoxicology
https://www.readbyqxmd.com/read/29577963/dopamine-d1-and-d3-receptor-polypharmacology-as-a-potential-treatment-approach-for-substance-use-disorder
#13
REVIEW
Ewa Galaj, Scott Ewing, Robert Ranaldi
In the search for efficacious pharmacotherapies to treat cocaine addiction much attention has been given to agents targeting dopamine D1 or D3 receptors because of the involvement of these receptors in drug-related behaviors. D1-like and D3 receptor partial agonists and antagonists have been shown to reduce drug reward, reinstatement of drug seeking and conditioned place preference (CPP) in rodents and non-human primates. However, translation of these encouraging results to clinical settings has been limited due to a number of factors including toxicity, poor pharmacokinetic properties and extrapyramidal and sedative side effects...
March 22, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29575801/drug-abuse-screening-with-exhaled-breath-and-oral-fluid-in-adults-with-substance-use-disorder
#14
Michel Arvidsson, Shahid Ullah, Johan Franck, Marja-Liisa Dahl, Olof Beck
In the treatment of substance use disorder regular laboratory-based testing has the dual purpose of monitoring compliance to the prescribed medication and the abstention from medically non-motivated substances (i.e. drug abuse screening). The principal specimen for testing is urine, but collection of urine has some disadvantages, e.g. being more time-consuming and more intrusive compared to other matrices, and there is also the risk of adulteration. This project aims to compare exhaled breath and oral fluid as alternative matrices for drug abuse screening in patients with substance use disorder...
March 25, 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29570477/is-preconception-substance-use-associated-with-unplanned-or-poorly-timed-pregnancy
#15
Lisbet S Lundsberg, Stephanie Peglow, Neena Qasba, Kimberly A Yonkers, Aileen M Gariepy
OBJECTIVE: Unplanned and poorly timed pregnancies are associated with adverse maternal and neonatal outcomes. Further understanding of preconception substance use with unplanned and poorly timed pregnancy is warranted. METHODS: Data were analyzed from a prospective study enrolling women early in pregnancy. Preconception tobacco, alcohol, marijuana, opioid, and cocaine use was ascertained. Participants reported whether their current pregnancy was planned and whether it was a good time to be pregnant...
March 22, 2018: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29567092/nucleus-accumbens-glt-1a-overexpression-reduces-glutamate-efflux-during-reinstatement-of-cocaine-seeking-but-is-not-sufficient-to-attenuate-reinstatement
#16
Carly Logan, Amber L LaCrosse, Lori A Knackstedt
Cocaine use disorder is a chronically relapsing disease without FDA-approved treatments. Using a rodent model of cocaine relapse, we and others have previously demonstrated that the beta-lactam antibiotic ceftriaxone attenuates cue- and cocaine-primed reinstatement of cocaine-seeking. Ceftriaxone restores cocaine-induced deficits in both system xc- and GLT-1 expression and function in the nucleus accumbens core (NAc). We recently demonstrated that restoration of GLT-1 expression in the NAc is necessary for ceftriaxone to attenuate reinstatement of cocaine-seeking...
March 19, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29558425/the-influence-of-high-and-low-doses-of-bisphenol-a-bpa-on-the-enteric-nervous-system-of-the-porcine-ileum
#17
Kamila Szymanska, Krystyna Makowska, Slawomir Gonkowski
Bisphenol A, used in the production of plastic, is able to leach from containers into food and cause multidirectional adverse effects in living organisms, including neurodegeneration and metabolic disorders. Knowledge of the impact of BPA on enteric neurons is practically non-existent. The destination of this study was to investigate the influence of BPA at a specific dose (0.05 mg/kg body weight/day) and at a dose ten times higher (0.5 mg/kg body weight/day), given for 28 days, on the porcine ileum. The influence of BPA on enteric neuron immunoreactive to selected neuronal active substances, including substance P (SP), vasoactive intestinal polypeptide (VIP), galanin (GAL), vesicular acetylcholine transporter (VAChT-used here as a marker of cholinergic neurons), and cocaine- and amphetamine-regulated transcript peptide (CART), was studied by the double immunofluorescence method...
March 20, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29550583/yawning-elicited-by-intravenous-ethanol-in-rhesus-monkeys-with-experience-self-administering-cocaine-and-ethanol-involvement-of-dopamine-d-3-receptors
#18
Paul W Czoty, William S John, Amy Hauck Newman, Michael A Nader
Characterization of the effects of long-term alcohol consumption on the brain would be aided by the development of behavioral assays that are relatively easy to implement in animal models of alcohol use disorders. Assessing unconditioned behaviors, such as drug-elicited yawning in models that permit long-term alcohol ingestion, may be a valuable complement to more invasive and costly procedures. The present studies investigated previous unexpected findings of ethanol-induced yawning in nonhuman primates. Subjects were adult male rhesus monkeys (n = 8), all of which had experience self-administering intravenous cocaine for several years...
October 17, 2017: Alcohol
https://www.readbyqxmd.com/read/29549313/astrocytic-metabolic-switch-is-a-novel-etiology-for-cocaine-and-hiv-1-tat-mediated-neurotoxicity
#19
Kalimuthusamy Natarajaseenivasan, Bianca Cotto, Santhanam Shanmughapriya, Alyssa A Lombardi, Prasun K Datta, Muniswamy Madesh, John W Elrod, Kamel Khalili, Dianne Langford
Calcium (Ca2+ ) dynamics and oxidative signaling control mitochondrial bioenergetics in the central nervous system, where astrocytes are a major energy source for neurons. Cocaine use exacerbates HIV-associated neurocognitive disorders, but little is known about disruptions in astrocyte metabolism in this context. Our data show that the HIV protein Tat and cocaine induce a metabolic switch from glucose to fatty acid oxidation in astrocytes, thereby limiting lactate transport to neurons. Mechanistic analyses revealed increased Mitochondrial Ca2+ Uniporter (MCU)-mediated Ca2+ uptake in astrocytes exposed to Tat and cocaine due to oxidation of MCU...
March 16, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29538089/the-impact-of-early-substance-use-disorder-treatment-response-on-treatment-outcomes-among-pregnant-women-with-primary-opioid-use
#20
Michelle Tuten, Heather Fitzsimons, Martin Hochheimer, Hendree E Jones, Margaret S Chisolm
OBJECTIVES: This study examined the impact of early patient response on treatment utilization and substance use among pregnant participants enrolled in substance use disorder (SUD) treatment. METHODS: Treatment responders (TRs) and treatment nonresponders (TNRs) were compared on pretreatment and treatment measures. Regression models predicted treatment utilization and substance use. RESULTS: TR participants attended more treatment and had lower rates of substance use relative to TNR participants...
March 13, 2018: Journal of Addiction Medicine
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