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Cocaine use disorder

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https://www.readbyqxmd.com/read/29040826/maintenance-on-naltrexone-amphetamine-decreases-cocaine-vs-food-choice-in-male-rhesus-monkeys
#1
Megan J Moerke, Matthew L Banks, Kejun Cheng, Kenner C Rice, S Stevens Negus
BACKGROUND: Cocaine use disorder remains a significant public health issue for which there are no FDA-approved pharmacotherapies. Amphetamine maintenance reduces cocaine use in preclinical and clinical studies, but the mechanism of this effect is unknown. Previous studies indicate a role for endogenous opioid release and subsequent opioid receptor activation in some amphetamine effects; therefore, the current study examined the role of mu-opioid receptor activation in d-amphetamine treatment effects in an assay of cocaine-vs-food choice...
October 13, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29033802/the-neurobiological-mechanism-of-chemical-aversion-emetic-therapy-for-alcohol-use-disorder-an-fmri-study
#2
Ralph L Elkins, Todd L Richards, Robert Nielsen, Richard Repass, Henriettae Stahlbrandt, Hunter G Hoffman
A recent NIH epidemiology study found the lifetime prevalence of alcohol use disorder in the United States to be 29%. Alcohol drinking behavior is strongly "learned" via pleasure center activation/reinforcement. Alcohol craving is a powerful desire to drink alcoholic beverages. Craving was added as one of the defining criteria for alcohol use disorder in DSM5, and craving reduction is becoming an increasingly important treatment goal. In the current study, patients with alcohol use disorder received 10 days of inpatient multi-modal treatments at Schick Shadel Hospital (SSH) of Seattle...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29033054/temporary-stages-and-motivational-variables-two-complementary-perspectives-in-the-help-seeking-process-for-mental-disorders
#3
Gema Del Valle Del Valle, Carmen Carrió, Amparo Belloch
INTRODUCTION: Help-seeking for mental disorders is a complex process, which includes different temporary stages, and in which the motivational variables play an especially relevant role. However, there is a lack of instruments to evaluate in depth both the temporary and motivational variables involved in the help-seeking process. This study aims to analyse in detail these two sets of variables, using a specific instrument designed for the purpose, to gain a better understanding of the process of treatment seeking...
October 9, 2017: Revista de Psiquiatrí́a y Salud Mental
https://www.readbyqxmd.com/read/29021121/effect-of-computerized-cognitive-behavioral-therapy-on-acquisition-of-coping-skills-among-cocaine-dependent-individuals-enrolled-in-methadone-maintenance
#4
Brian D Kiluk, Elise E DeVito, Matthew B Buck, Karen Hunkele, Charla Nich, Kathleen M Carroll
The acquisition of coping skills has long been considered one of the putative mechanisms of cognitive behavioral therapy (CBT) for substance use disorders, yet consistent statistical support is lacking. This study sought to replicate and extend prior findings regarding the quality of coping skills as a mediator of abstinence outcomes from a computerized CBT program for substance users. Participants were methadone-maintained, cocaine dependent individuals enrolled in a clinical trial evaluating the efficacy of computer-based training for CBT ('CBT4CBT') as an add-on to treatment as usual (TAU+CBT4CBT) compared to TAU only...
November 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/29020291/reward-sensitivity-and-waiting-impulsivity-shift-towards-reward-valuation-away-from-action-control
#5
Daisy J Mechelmans, Daniela Strelchuk, Nuria Donamayor-Alonso, Paula Banca, Trevor W Robbins, Kwangyeol Baek, Valerie Voon
Background: Impulsivity and reward expectancy are commonly inter-related. Waiting impulsivity, measured using the rodent 5-Choice Serial Reaction Time (5-CSRT) task, predicts compulsive cocaine seeking and sign (or cue) tracking. Here we assess human waiting impulsivity using a novel translational task, the 4-CSRT, and the relationship with reward cues. Methods: Healthy volunteers (n=29) performed the monetary incentive delay task as a functional MRI study where subjects observe a cue predicting reward (cue) and wait to respond for high (£5), low (£1) or no reward...
August 8, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29017089/reduced-interhemispheric-executive-control-network-coupling-in-men-during-early-cocaine-abstinence-a-pilot-study
#6
Julie M McCarthy, Chun S Zuo, Justin M Shepherd, Nadeeka Dias, Scott E Lukas, Amy C Janes
BACKGROUND: Individuals who use cocaine have fewer cognitive resources needed to maintain abstinence. This is evidenced by blunted brain function during cognitive control tasks and reduced communication between brain regions associated with cognitive function. For instance, relapse vulnerability is heightened in individuals with less communication between the right and left frontoparietal executive control network (ECN). Given that recent cocaine use enhances such communication, it is plausible that recency of cocaine use influences interhemispheric ECN communication...
October 5, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28991519/association-between-binge-drug-use-and-suicide-attempt-among-people-who-inject-drugs
#7
Charles Fournier, Maykel Farag Ghabrash, Adelina Artenie, Elise Roy, Geng Zang, Julie Bruneau, Didier Jutras Aswad
BACKGROUND: People who inject drugs (PWID) have an elevated risk of suicide attempt. While different substances are associated with suicide attempt, the overall risk posed by binge behavior, a high risk pattern of drug use, remains unclear. Our objective is to assess the association between binge drug use and suicide attempt in a prospective cohort of PWID in Montreal, Canada. METHODS: Participants answered a biannual interviewer-administered questionnaire compiling information on sociodemographics, pattern of substance use (cocaine, amphetamine, opioids, sedative-hypnotics, alcohol and cannabis), psychosocial stressors and related markers...
October 9, 2017: Substance Abuse
https://www.readbyqxmd.com/read/28990593/riluzole-impairs-cocaine-reinstatement-and-restores-adaptations-in-intrinsic-excitability-and-glt-1-expression
#8
Marian T Sepulveda-Orengo, Kati L Healey, Ronald Kim, Alyson C Auriemma, Jennifer Rojas, Nicholas Woronoff, Rachel Hyppolite, Kathryn J Reissner
Adaptations in glutamate signaling within the brain's reward circuitry are observed following withdrawal from several abused drugs, including cocaine. These include changes in intrinsic cellular excitability, glutamate release, and glutamate uptake. Pharmacological or optogenetic reversal of these adaptations have been shown to reduce measures of cocaine craving and seeking, raising the hypothesis that regulation of glutamatergic signaling represents a viable target for the treatment of substance use disorders...
October 9, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28984746/late-reduction-of-cocaine-cravings-in-a-randomized-double-blind-trial-of-aripiprazole-vs-perphenazine-in-schizophrenia-and-comorbid-cocaine-dependence
#9
Thomas Beresford, Jennifer Buchanan, Elizabeth Brie Thumm, Chad Emrick, David Weitzenkamp, Patrick J Ronan
PURPOSE: Co-occurring schizophrenia spectrum disorder and International Statistical Classification of Diseases, 10th Revision cocaine dependence present a particularly destructive constellation that is often difficult to treat. Both conditions raise dopamine transmission effects in the brain. Traditional neuroleptics block dopamine receptors, whereas aripiprazole modulates dopamine activity as an agonist/antagonist. We tested whether dopamine modulation is superior to dopamine blocking in dual-diagnosis patients...
October 3, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28983445/impact-of-cocaine-use-on-acute-ischemic-stroke-patients-insights-from-nationwide-inpatient-sample-in-the-united-states
#10
Rupak Desai, Upenkumar Patel, Chintan Rupareliya, Sandeep Singh, Manan Shah, Rikinkumar S Patel, Smit Patel, Zabeen Mahuwala
Cocaine is the third most common substance of abuse after cannabis and alcohol. The use of cocaine as an illicit substance is implicated as a causative factor for multisystem derangements ranging from an acute crisis to chronic complications. Vasospasm is the proposed mechanism behind adverse events resulting from cocaine abuse, acute ischemic strokes (AIS) being one of the few. Our study looked into in-hospital outcomes owing to cocaine use in the large population based study of AIS patients. Using the national inpatient sample (NIS) database from 2014 of United States of America, we identified AIS patients with cocaine use using International Classification of Disease, Ninth Revision (ICD-9) codes...
August 2, 2017: Curēus
https://www.readbyqxmd.com/read/28983261/persistency-of-cannabis-use-predicts-violence-following-acute-psychiatric-discharge
#11
Jules R Dugré, Laura Dellazizzo, Charles-Édouard Giguère, Stéphane Potvin, Alexandre Dumais
BACKGROUND: Violence is a major concern and is prevalent across several mental disorders. The use of substances has been associated with an exacerbation of psychiatric symptoms as well as with violence. Compared to other substances such as alcohol and cocaine, existing literature on the cannabis-violence relationship has been more limited, with most studies being conducted in the general population, and has shown controversial results. Evidence has suggested a stronger relationship when examining the effects of the persistency of cannabis use on future violent behaviors...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28970640/a-comparison-of-mazur-s-k-and-area-under-the-curve-for-describing-steep-discounters
#12
Jin H Yoon, Richard De La Garza, Thomas F Newton, Robert Suchting, Matthew T Weaver, Gregory S Brown, Yasmine Omar, Ilana Haliwa
Delay discounting describes how a reward loses value as a function of increasing delay to its receipt and has been reliably associated with a variety of vulnerable populations including those with substance use disorders (SUDs). Two commonly used models to assess delay discounting in the field of SUDs include log k derived from Mazur's hyperbolic equation and area under the curve (AUC). In the current study, we compared log k with AUC on delay discounting data obtained from non-treatment seeking, cocaine- and methamphetamine-dependent volunteers...
September 2017: Psychological Record
https://www.readbyqxmd.com/read/28965780/drug-related-predictors-of-readmission-for-schizophrenia-among-patients-admitted-to-treatment-for-drug-use-disorders
#13
Kristine Rømer Thomsen, Birgitte Thylstrup, Michael Mulbjerg Pedersen, Mads Uffe Pedersen, Erik Simonsen, Morten Hesse
BACKGROUND: Patients with schizophrenia and comorbid drug use disorders (DUD) have a severe course of illness. Despite strong evidence that drug use can exacerbate psychotic symptoms, we have limited knowledge of how specific drugs may increase risk of schizophrenia readmission in this group. This study aimed to assess drug-related predictors of readmission for schizophrenia among a national cohort of patients with a history of schizophrenia admitted to DUD treatment. METHODS: A record-linkage study was used to assess drug-related factors associated with readmission to mental health treatment for schizophrenia, using a consecutive cohort of 634 patients admitted to DUD treatment between 2000 and 2006 in Danish treatment services and tracked until February 2013 or death, controlling for baseline psychiatric treatment variables...
September 28, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28961544/trends-and-correlates-of-cocaine-use-and-cocaine-use-disorder-in-the-united-states-from-2011-to-2015
#14
William S John, Li-Tzy Wu
BACKGROUND: Recent epidemiological data suggest a resurgence in cocaine use (CU) and cocaine-related problems in the United States. Demographic trends and correlates of problem CU are needed to determine potential factors that may be influencing the increased trend and to inform targeted prevention and intervention strategies. METHODS: Trends in any past-year CU, weekly CU, and cocaine use disorder (CUD) were examined among persons aged ≥12 years using the National Survey on Drug Use and Health from 2011 to 2015...
September 18, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28958905/-uro-and-nephrotoxic-effects-of-drugs-of-abuse-literature-review-and-pharmaco-epidemiological-survey-in-france-and-in-the-marseille-area
#15
Marion Gully, Élisabeth Frauger, Michel Spadari, Liselotte Pochard, Vanessa Pauly, Fanny Romain, Bertrand Gondouin, Marion Sallée, Julie Moussi-Frances, Stéphane Burtey, Bertrand Dussol, Laurent Daniel, Joëlle Micallef, Noémie Jourde-Chiche
A great diversification of drugs of abuse has been observed in recent years, both in the populations using them and in the types of drugs. Although dependency and psychiatric disorders associated with the abuse of these substances is well known, somatic complications, uro-nephrotoxicity in particular, are less recognized. We propose here an overview of the products used by drugs abusers in France, through the analysis of the national pharmaco-epidemiological study Observation des produits psychotropes illicites ou détournés de leur utilisation médicamenteuse (OPPIDUM)...
September 25, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/28957777/unseen-scars-cocaine-patients-with-prior-trauma-evidence-heightened-resting-state-functional-connectivity-rsfc-between-the-amygdala-and-limbic-striatal-regions
#16
Michael J Gawrysiak, Kanchana Jagannathan, Paul Regier, Jesse J Suh, Kyle Kampman, Timothy Vickery, Anna Rose Childress
BACKGROUND: Substance use disorder (SUD) patients with a history of trauma exhibit poorer treatment outcome, greater functional impairment and higher risk for relapse. Endorsement of prior trauma has, in several SUD populations, been linked to abnormal functional connectivity (FC) during task-based studies. We examined amygdala FC in the resting state (RS), testing for differences between cocaine patients with and without prior trauma. METHODS: Patients with cocaine use disorder (CUD; n=34) were stabilized in an inpatient setting prior to a BOLD fMRI scan...
September 20, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28957664/hdac5-and-its-target-gene-npas4-function-in-the-nucleus-accumbens-to-regulate-cocaine-conditioned-behaviors
#17
Makoto Taniguchi, Maria B Carreira, Yonatan A Cooper, Ana-Clara Bobadilla, Jasper A Heinsbroek, Nobuya Koike, Erin B Larson, Evan A Balmuth, Brandon W Hughes, Rachel D Penrod, Jaswinder Kumar, Laura N Smith, Daniel Guzman, Joseph S Takahashi, Tae-Kyung Kim, Peter W Kalivas, David W Self, Yingxi Lin, Christopher W Cowan
Individuals suffering from substance-use disorders develop strong associations between the drug's rewarding effects and environmental cues, creating powerful, enduring triggers for relapse. We found that dephosphorylated, nuclear histone deacetylase 5 (HDAC5) in the nucleus accumbens (NAc) reduced cocaine reward-context associations and relapse-like behaviors in a cocaine self-administration model. We also discovered that HDAC5 associates with an activity-sensitive enhancer of the Npas4 gene and negatively regulates NPAS4 expression...
September 27, 2017: Neuron
https://www.readbyqxmd.com/read/28944942/paramedian-forehead-flap-for-repair-of-refractory-high-flow-anterior-skull-base-csf-leak
#18
Jeremy Ciporen, Brandon Lucke-Wold, Haley Gillham, David Cua, Jason Kim, Paul Akins
AIM: The paramedian forehead flap (PMFF) has been well described for nasal reconstruction. However, it has never been reported for use in the repair of high flow anterior skull base cerebral spinal fluid (CSF) leaks. MATERIAL AND METHODS: The patient is a 55 yo African American male cocaine abuser who initially presented with a high flow anterior skull base CSF leak, extensive pneumocephalus, and intra-cerebral and intra-ventricular abscesses with an oro-nasal-cerebral fistula...
July 11, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28942289/polysubstance-use-by-psychiatry-inpatients-with-co-occurring-mental-health-and-substance-use-disorders
#19
Christine Timko, Mark Ilgen, Marie Haverfield, Alexandra Shelley, Jessica Y Breland
BACKGROUND: Polysubstance use, the consumption of more than one substance over a defined period, is common and associated with psychiatric problems and poor treatment adherence and outcomes. This study examined past-month polysubstance use at intake among psychiatry inpatients with co-occurring mental health and substance use disorders, and outcomes 3 months later. METHODS: Participants (n=406 psychiatry inpatients with documented mental health and substance use disorders) completed a baseline and a 3-month follow-up (84%) interview...
September 15, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28942288/differences-in-behavioral-health-disorders-and-unmet-treatment-needs-between-medical-marijuana-users-and-recreational-marijuana-users-results-from-a-national-adult-sample
#20
Ji-Yeun Park, Li-Tzy Wu
BACKGROUND: Available data suggest that medical marijuana users may have more mental health problems than recreational marijuana users. There is limited information about differences in behavioral health disorders and unmet treatment needs between medical and recreational marijuana users. METHODS: We compared past-year prevalence of behavioral health disorders and unmet treatment needs across three marijuana subgroups (recreational use only, medical use only, and both)...
September 14, 2017: Drug and Alcohol Dependence
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