Xin Wang, Kongliang He, Tingting Chen, Bing Shi, Jie Yang, Wanyue Geng, Lei Zhang, Chunyan Zhu, Gongjun Ji, Yanghua Tian, Tongjian Bai, Yi Dong, Yuejia Luo, Kai Wang, Fengqiong Yu
BACKGROUND: There are currently no effective treatments specifically targeting anticipatory anhedonia, a major symptom of severe depression which is associated with poor outcomes. The present study investigated the efficacy of individualized repetitive transcranial magnetic stimulation (rTMS) targeting the left dorsolateral prefrontal cortex (lDLPFC)-nucleus accumbens (NAcc) network on anticipatory anhedonia in depression. METHODS: This randomized, double-blind, sham-controlled clinical trial (NCT03991572) enrolled 56 depression patients with anhedonia symptoms...
June 22, 2021: Depression and Anxiety