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https://www.readbyqxmd.com/read/28917695/the-impact-of-gabaergic-drugs-on-tms-induced-brain-oscillations-in-human-motor-cortex
#1
Isabella Premoli, Til O Bergmann, Matteo Fecchio, Mario Rosanova, Andrea Biondi, Paolo Belardinelli, Ulf Ziemann
Brain responses to transcranial magnetic stimulation (TMS) as measured with electroencephalography (EEG) have so far been assessed either by TMS-evoked EEG potentials (TEPs), mostly reflecting phase-locked neuronal activity, or time-frequency-representations (TFRs), reflecting oscillatory power arising from a mixture of both evoked (i.e., phase-locked) and induced (i.e., non-phase-locked) responses. Single-pulse TMS of the human primary motor cortex induces a specific pattern of oscillatory changes, characterized by an early (30-200 ms after TMS) synchronization in the α- and β-bands over the stimulated sensorimotor cortex and adjacent lateral frontal cortex, followed by a late (200-400 ms) α- and β-desynchronization over the stimulated and contralateral sensorimotor cortex...
September 14, 2017: NeuroImage
https://www.readbyqxmd.com/read/28910407/the-spectral-features-of-eeg-responses-to-transcranial-magnetic-stimulation-of-the-primary-motor-cortex-depend-on-the-amplitude-of-the-motor-evoked-potentials
#2
Matteo Fecchio, Andrea Pigorini, Angela Comanducci, Simone Sarasso, Silvia Casarotto, Isabella Premoli, Chiara-Camilla Derchi, Alice Mazza, Simone Russo, Federico Resta, Fabio Ferrarelli, Maurizio Mariotti, Ulf Ziemann, Marcello Massimini, Mario Rosanova
Transcranial magnetic stimulation (TMS) of the primary motor cortex (M1) can excite both cortico-cortical and cortico-spinal axons resulting in TMS-evoked potentials (TEPs) and motor-evoked potentials (MEPs), respectively. Despite this remarkable difference with other cortical areas, the influence of motor output and its amplitude on TEPs is largely unknown. Here we studied TEPs resulting from M1 stimulation and assessed whether their waveform and spectral features depend on the MEP amplitude. To this aim, we performed two separate experiments...
2017: PloS One
https://www.readbyqxmd.com/read/28904521/mesh-displacement-after-bilateral-inguinal-hernia-repair-with-no-fixation
#3
Christiano Marlo Paggi Claus, Gabriela Moreira Rocha, Antonio Carlos Ligocki Campos, João Augusto Nocera Paulin, Julio Cesar Uili Coelho
BACKGROUND AND OBJECTIVES: About 20% of patients with inguinal hernia present bilateral hernias in the diagnosis. In these cases, laparoscopic procedure is considered gold standard approach. Mesh fixation is considered important step toward avoiding recurrence. However, because of cost and risk of pain, real need for mesh fixation has been debated. For bilateral inguinal hernias, there are few specific data about non fixation and mesh displacement. We assessed mesh movement in patients who had undergone laparoscopic bilateral inguinal hernia repair without mesh fixation and compared the results with those obtained in patients with unilateral hernia...
July 2017: JSLS: Journal of the Society of Laparoendoscopic Surgeons
https://www.readbyqxmd.com/read/28880984/association-of-a-perioperative-education-program-with-unplanned-readmission-following-total-laryngectomy
#4
Evan M Graboyes, Dorina Kallogjeri, Jan Zerega, Sara Kukuljan, Linda Neal, Kelsey M Rosenquist, Brian Nussenbaum
Importance: Patients undergoing total laryngectomy (TL) are at high risk for 30-day hospital readmission. Strategies to decrease the readmission rate remain unknown. Objectives: To assess the association of a comprehensive perioperative TL education program with unplanned readmissions; to determine the program's association with the rate of readmissions for stomal or tracheoesophageal puncture (TEP) complications and patient and caregiver knowledge of and preparedness for TL...
September 7, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28878892/laparoscopic-and-open-inguinal-hernia-repair-patient-reported-outcomes-in-the-elderly-from-a-single-centre-a-prospective-cohort-study
#5
K Bowling, S El-Badawy, E Massri, J Rait, J Atkinson, S Leong, A Stuart, G Srinivas
BACKGROUND: With those over 65 making up over 16% of the UK's population, surgeons are counselling increasing numbers of elderly patients for hernia repair. Data is currently lacking comparing different repair methods of inguinal hernias in the elderly population with regards to patient reported outcomes. AIM: To compare open and laparoscopic hernia repair in patients >65 years old and those <65 years old with respect to patient reported outcomes. METHOD: As part of a quality assurance process patients receive a telephone consultation day 2 post procedure...
October 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28876694/comparing-outcomes-after-laparoscopic-totally-extraperitoneal-repair-versus-open-lichtenstein-repair-of-inguinoscrotal-hernia-at-dr-george-mukhari-academic-hospital
#6
B Shazi, M Z Koto
BACKGROUND: Inguinal hernia is a common surgical condition. Inguinal hernia can present with a wide variety of symptoms. It can even extend into the scrotum resulting in what is known as an inguinoscrotal hernia. At Dr George Mukhari Hospital, approximately 5-10% of patients with inguinal hernia present with inguinoscrotal hernia. There is paucity of data on the role of laparoscopy in the management of inguinoscrotal hernia. At our institution some of the patients with inguinoscrotal hernia are offered open (Lichtenstein) repair whilst others are offered totally extraperitoneal (TEP) laparoscopic repair...
June 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28874153/thioester-containing-proteins-regulate-the-toll-pathway-and-play-a-role-in-drosophila-defence-against-microbial-pathogens-and-parasitoid-wasps
#7
Anna Dostálová, Samuel Rommelaere, Mickael Poidevin, Bruno Lemaitre
BACKGROUND: Members of the thioester-containing protein (TEP) family contribute to host defence in both insects and mammals. However, their role in the immune response of Drosophila is elusive. In this study, we address the role of TEPs in Drosophila immunity by generating a mutant fly line, referred to as TEPq (Δ) , lacking the four immune-inducible TEPs, TEP1, 2, 3 and 4. RESULTS: Survival analyses with TEPq (Δ) flies reveal the importance of these proteins in defence against entomopathogenic fungi, Gram-positive bacteria and parasitoid wasps...
September 5, 2017: BMC Biology
https://www.readbyqxmd.com/read/28864955/laparoscopic-extraperitoneal-repair-versus-open-inguinal-hernia-repair-20-year-follow-up-of-a-randomized-controlled-trial
#8
A Barbaro, H Kanhere, J Bessell, G J Maddern
PURPOSE: This study compared the long-term recurrence rates of laparoscopic totally extraperitoneal (TEP) and open inguinal hernia repair in patients from a randomised trial completed in 1994. Laparoscopic inguinal hernia surgery, especially TEP repair, has gained widespread acceptance in recent years. There is still paucity of data on long-term follow-up comparing recurrence rates for open and laparoscopic techniques. This is the first study providing direct long-term comparative data about these techniques...
September 1, 2017: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/28853484/integrating-multiple-fitting-regression-and-bayes-decision-for-cancer-diagnosis-with-transcriptomic-data-from-tumor-educated-blood-platelets
#9
Guangzao Huang, Mingshun Yuan, Moliang Chen, Lei Li, Wenjie You, Hanjie Li, James J Cai, Guoli Ji
The application of machine learning in cancer diagnostics has shown great promise and is of importance in clinic settings. Here we consider applying machine learning methods to transcriptomic data derived from tumor-educated platelets (TEPs) from individuals with different types of cancer. We aim to define a reliability measure for diagnostic purposes to increase the potential for facilitating personalized treatments. To this end, we present a novel classification method called MFRB (for Multiple Fitting Regression and Bayes decision), which integrates the process of multiple fitting regression (MFR) with Bayes decision theory...
August 30, 2017: Analyst
https://www.readbyqxmd.com/read/28852860/bilateral-endoscopic-totally-extraperitoneal-tep-inguinal-hernia-repair-does-not-impair-male-fertility
#10
M M Roos, G J Clevers, E J Verleisdonk, P H Davids, C van de Water, R J Spermon, L S Mulder, J P J Burgmans
PURPOSE: Endoscopic totally extraperitoneal (TEP) hernia repair with polypropylene mesh has become a well-established technique. However, since the mesh is placed in close contact with the spermatic cord, mesh-induced inflammation may affect its structures, possibly resulting in impaired fertility. The aim of this observational prospective cohort study was to assess fertility after bilateral endoscopic TEP inguinal hernia repair in male patients. METHODS: Fifty-seven male patients (22-60 years old) with primary, reducible, bilateral inguinal hernias underwent elective bilateral endoscopic TEP hernia repair with use of polypropylene mesh...
August 29, 2017: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/28852831/uterine-intravascular-lymphoma-as-a-cause-of-fever-of-unknown-origin
#11
Jérôme Hadjadj, Hubert Nielly, Eve Piekarski, Wendy Cuccuini, Bénedicte Deau-Fischer, Muriel Hourseau, Khadija Benali, Claire Fieschi, Marc Aletti, Thomas Papo, Eric Oksenhendler, Lionel Galicier, David Boutboul
Primary intravascular large B cell lymphoma (IVL) remains a diagnostic challenge because of non-specific clinical, laboratory and imaging findings. The aim of the study was to analyse the major characteristics of IVL with uterine involvement. We retrospectively collected features of IVL with uterine involvement that was proven histologically or demonstrated by significant (18)FDG uptake on (18)FDG-PET/CT. Findings were compared to a comprehensive literature review. Five patients were identified. All of them were admitted for fever of unknown origin (FUO), with haemophagocytic lymphohistiocytosis in three cases...
August 29, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28845132/cell-free-dna-in-non-small-cell-lung-cancer
#12
Vaida Gedvilaitė, Diana Schveigert, Saulius Cicėnas
Lung cancer is the leading cause of cancer-associated deaths worldwide. Surgery is the standard treatment for early-stage non-small cell lung cancer (NSCLC). Advances in the knowledge of the biology of non-small cell lung cancer have revealed molecular information used for systemic cancer therapy targeting metastatic disease, with an important impact on patients' overall survival (OS) and quality of life. However, a biopsy of overt metastases is an invasive procedure limited to certain locations and not easily acceptable in the clinic...
2017: Acta medica Lituanica
https://www.readbyqxmd.com/read/28837930/the-indirect-assessment-of-social-anhedonia-in-chinese-adolescents-preliminary-findings
#13
Diane C Gooding, Raymond C K Chan, Han-Yu Zhou, Zhi Li, Eric F C Cheung
Nearly all self-report measures of anhedonia have been developed for use in adults. Recently we developed an age and developmentally appropriate measure of social/interpersonal pleasure for adolescents (ACIPS-A), whereby lower scores are indicative of social anhedonia. However the scale had not been administered to Eastern samples. The adolescent version of the Anticipatory and Consummatory Interpersonal Pleasure Scale (ACIPS-A) was administered to a general, community-derived Chinese adolescent sample of 442 students, including 186 males (44%), who ranged in age from 12 to 18 years old...
August 12, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28837753/functional-outcomes-and-quality-of-life-after-total-laryngectomy-with-noncircumferential-radial-forearm-free-tissue-transfer
#14
Donna J Graville, Andrew D Palmer, Christine M Chambers, Lauren Ottenstein, Breanne Whalen, Peter E Andersen, Mark K Wax, James I Cohen
BACKGROUND: The purpose of this study was to compare long-term functional and quality of life (QOL) outcomes after total laryngectomy with primary closure and those who underwent reconstruction with noncircumferential radial free forearm tissue transfer (RFFTT). METHODS: Sixty-seven patients were identified by chart review and underwent long-term follow-up using QOL surveys and standardized interviews. RESULTS: The RFFTT group had significantly higher rates of chemotherapy, gastric tube (G-tube) at surgery, and postoperative stricture...
August 24, 2017: Head & Neck
https://www.readbyqxmd.com/read/28836257/-efficacy-comparison-of-the-laparoscopic-total-extraperitoneal-prosthetic-and-the-lichtenstein-herniorrhaphy-for-inguinal-hernia
#15
Yiliang Li, Zhi Wang, Lemu Ke, Fuzeng Su, Cheng Zhang, Huiling Li, Zhi Du, Zhikai Zhu, Song Li
OBJECTIVE: To compare the efficacy and safety between laparoscopic total extraperitoneal prosthetic (TEP) and Lichtenstein herniorrhaphy in the treatment of inguinal hernia (IH). METHODS: Clinical data of 158 IH patients at our hospital from October 2015 to October 2016 were retrospectively analyzed. Among 158 patients, 85 patients underwent TEP (TEP group), and 73 underwent Lichtenstein herniorrhaphy(Lichtenstein group). Patients of TEP group received general anesthesia...
August 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28831092/photo-flocculation-of-microbial-mat-extracellular-polymeric-substances-and-their-transformation-into-transparent-exopolymer-particles-chemical-and-spectroscopic-evidences
#16
Mashura Shammi, Xiangliang Pan, Khan M G Mostofa, Daoyong Zhang, Cong-Qiang Liu
Upon exposure to sunlight extracellular polymeric substances (EPS) were partially transformed into transparent exopolymer particles (TEP) and unstable flocs of different sizes without the addition of any precursors. Parallel factor (PARAFAC) modelling of the sample fluorescence spectra identified humic-like and protein-like or tyrosine-like components in both untreated and irradiated EPS samples. After 58 hours of solar irradiation, humic-like substances were entirely decomposed, while the regenerated protein-like substance from EPS was the key component in the irradiated samples...
August 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28828918/use-of-ultrasound-for-sizing-tracheoesophageal-puncture-prostheses
#17
Aaron Smith, Vikrum Thimmappa, Julia Jones, Courtney Shires, Merry Sebelik
Tracheoesophageal puncture (TEP) with voice prosthesis placement is the gold standard voice rehabilitation following total laryngectomy. Ultrasound may be useful to determine tracheoesophageal wall thickness, guiding prosthesis choice. Therefore, 14 patients undergoing total laryngectomy and TEP or prosthesis change with 16-mHz ultrasound measurement of the posterior tracheal wall were included. Seven patients underwent secondary TEP, 3 primary TEP, and 4 TEP changes. Six patients underwent flap reconstruction, while 8 patients were closed primarily...
August 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28810146/swarm-intelligence-enhanced-detection-of-non-small-cell-lung-cancer-using-tumor-educated-platelets
#18
Myron G Best, Nik Sol, Sjors G J G In 't Veld, Adrienne Vancura, Mirte Muller, Anna-Larissa N Niemeijer, Aniko V Fejes, Lee-Ann Tjon Kon Fat, Anna E Huis In 't Veld, Cyra Leurs, Tessa Y Le Large, Laura L Meijer, Irsan E Kooi, François Rustenburg, Pepijn Schellen, Heleen Verschueren, Edward Post, Laurine E Wedekind, Jillian Bracht, Michelle Esenkbrink, Leon Wils, Francesca Favaro, Jilian D Schoonhoven, Jihane Tannous, Hanne Meijers-Heijboer, Geert Kazemier, Elisa Giovannetti, Jaap C Reijneveld, Sander Idema, Joep Killestein, Michal Heger, Saskia C de Jager, Rolf T Urbanus, Imo E Hoefer, Gerard Pasterkamp, Christine Mannhalter, Jose Gomez-Arroyo, Harm-Jan Bogaard, David P Noske, W Peter Vandertop, Daan van den Broek, Bauke Ylstra, R Jonas A Nilsson, Pieter Wesseling, Niki Karachaliou, Rafael Rosell, Elizabeth Lee-Lewandrowski, Kent B Lewandrowski, Bakhos A Tannous, Adrianus J de Langen, Egbert F Smit, Michel M van den Heuvel, Thomas Wurdinger
Blood-based liquid biopsies, including tumor-educated blood platelets (TEPs), have emerged as promising biomarker sources for non-invasive detection of cancer. Here we demonstrate that particle-swarm optimization (PSO)-enhanced algorithms enable efficient selection of RNA biomarker panels from platelet RNA-sequencing libraries (n = 779). This resulted in accurate TEP-based detection of early- and late-stage non-small-cell lung cancer (n = 518 late-stage validation cohort, accuracy, 88%; AUC, 0.94; 95% CI, 0...
August 14, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28809644/-endoprosthesis-infections-guidelines-for-antibiotic-therapy-common-guidelines-of-the-czech-society-for-orthopaedics-and-traumatology-and-the-society-for-infectious-diseases-of-the-czech-medical-association-of-j-e-purkyn%C3%A4
#19
D Musil, M Balejová, M Horníková, A Chrdle, N Mallátová, O Nyč, V Chmelík, J Gallo, D Jahoda, J Stehlík
PURPOSE OF THE STUDY This study aims to articulate regional guidelines for curative and suppressive antibiotic therapy of total joint replacement infections. MATERIAL AND METHODS When developing the standard, used as source materials were the published foreign guidelines for antibiotic therapy of prosthetic joint infections, the analysis of resistance of bacterial strains conducted in the Hospital in České Budějovice, a.s. and the assessment of strain resistance for the Czech Republic published by the European Antimicrobial Resistance Surveillance Network (EARS-Net)...
2017: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
https://www.readbyqxmd.com/read/28809132/impact-of-primary-tracheoesophageal-puncture-on-outcomes-after-total-laryngectomy
#20
Aru Panwar, Oleg Militsakh, Robert Lindau, Andrew Coughlin, Harlan Sayles, Katherine R Rieke, William Lydiatt, Daniel Lydiatt, Russell Smith
Objectives To identify differences in postoperative wound complications associated with a primary tracheoesophageal puncture (TEP) at the time of laryngectomy versus no TEP. Study Design Retrospective review of large national data set. Setting Academic and nonacademic health care facilities in United States, contributing de-identified, risk-adjusted clinical data to the American College of Surgeons National Surgical Quality Improvement Program. Subjects and Methods The National Surgical Quality Improvement Program data set for years 2006 to 2012 identified 430 patients who underwent total laryngectomy with or without a primary TEP...
August 1, 2017: Otolaryngology—Head and Neck Surgery
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