Read by QxMD icon Read

R. Kuhn

G Vinayarani, H S Prakash
Endophytic fungi have been isolated from the healthy turmeric (Curcuma longa L.) rhizomes from South India. Thirty-one endophytes were identified based on morphological and ITS-rDNA sequence analysis. The isolated endophytes were screened for antagonistic activity against Pythium aphanidermatum (Edson) Fitzp., and Rhizoctonia solani Kuhn., causing rhizome rot and leaf blight diseases in turmeric respectively. Results revealed that only six endophytes showed > 70% suppression of test pathogens in antagonistic dual culture assays...
March 14, 2018: World Journal of Microbiology & Biotechnology
Matthew J Kraeutler, Eric C McCarty, John W Belk, Brian R Wolf, Carolyn M Hettrich, Shannon F Ortiz, Jonathan T Bravman, Keith M Baumgarten, Julie Y Bishop, Matthew J Bollier, Robert H Brophy, James L Carey, James E Carpenter, Charlie L Cox, Brian T Feeley, John A Grant, Grant L Jones, John E Kuhn, John D Kelly, C Benjamin Ma, Robert G Marx, Bruce S Miller, Brian J Sennett, Matthew V Smith, Rick W Wright, Alan L Zhang
BACKGROUND: Shoulder instability is a common diagnosis among patients undergoing shoulder surgery. PURPOSE: To perform a descriptive analysis of patients undergoing surgery for shoulder instability through a large multicenter consortium. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: All patients undergoing surgery for shoulder instability who were enrolled in the MOON Shoulder Instability Study were included...
March 1, 2018: American Journal of Sports Medicine
B L Ehlmann, K S Edgett, B Sutter, C N Achilles, M L Litvak, M G A Lapotre, R Sullivan, A A Fraeman, R E Arvidson, D F Blake, N T Bridges, P G Conrad, A Cousin, R T Downs, T S J Gabriel, R Gellert, V E Hamilton, C Hardgrove, J R Johnson, S Kuhn, P R Mahaffy, S Maurice, M McHenry, P-Y Meslin, D W Ming, M E Minitti, J M Morookian, R V Morris, C D O'Connell-Cooper, P C Pinet, S K Rowland, S Schröder, K L Siebach, N T Stein, L M Thompson, D T Vaniman, A R Vasavada, D F Wellington, R C Wiens, A S Yen
The Mars Science Laboratory Curiosity rover performed coordinated measurements to examine the textures and compositions of aeolian sands in the active Bagnold dune field. The Bagnold sands are rounded to subrounded, very fine to medium sized (~45-500 μm) with ≥6 distinct grain colors. In contrast to sands examined by Curiosity in a dust-covered, inactive bedform called Rocknest and soils at other landing sites, Bagnold sands are darker, less red, better sorted, have fewer silt-sized or smaller grains, and show no evidence for cohesion...
December 2017: Journal of Geophysical Research. Planets
Taylor Kuhn, Tobias Kaufmann, Nhat Trung Doan, Lars T Westlye, Jacob Jones, Rodolfo A Nunez, Susan Y Bookheimer, Elyse J Singer, Charles H Hinkin, April D Thames
OBJECTIVE: HIV infection and aging are both associated with neurodegeneration. However, whether the aging process alone or other factors associated with advanced age account for the progression of neurodegeneration in the aging HIV-positive (HIV+) population remains unclear. METHODS: HIV+ (n = 70) and HIV-negative (HIV-, n = 34) participants underwent diffusion tensor imaging (DTI) and metrics of microstructural properties were extracted from regions of interest (ROIs)...
February 27, 2018: Human Brain Mapping
K P Adhikari, A Deur, L El Fassi, H Kang, S E Kuhn, M Ripani, K Slifer, X Zheng, S Adhikari, Z Akbar, M J Amaryan, H Avakian, J Ball, I Balossino, L Barion, M Battaglieri, I Bedlinskiy, A S Biselli, P Bosted, W J Briscoe, J Brock, S Bültmann, V D Burkert, F Thanh Cao, C Carlin, D S Carman, A Celentano, G Charles, J-P Chen, T Chetry, S Choi, G Ciullo, L Clark, P L Cole, M Contalbrigo, V Crede, A D'Angelo, N Dashyan, R De Vita, E De Sanctis, M Defurne, C Djalali, G E Dodge, V Drozdov, R Dupre, H Egiyan, A El Alaoui, L Elouadrhiri, P Eugenio, G Fedotov, A Filippi, Y Ghandilyan, G P Gilfoyle, E Golovatch, R W Gothe, K A Griffioen, M Guidal, N Guler, L Guo, K Hafidi, H Hakobyan, C Hanretty, N Harrison, M Hattawy, D Heddle, K Hicks, M Holtrop, C E Hyde, Y Ilieva, D G Ireland, E L Isupov, D Jenkins, H S Jo, S C Johnston, K Joo, S Joosten, M L Kabir, C D Keith, D Keller, G Khachatryan, M Khachatryan, M Khandaker, W Kim, A Klein, F J Klein, P Konczykowski, K Kovacs, V Kubarovsky, L Lanza, P Lenisa, K Livingston, E Long, I J D MacGregor, N Markov, M Mayer, B McKinnon, D G Meekins, C A Meyer, T Mineeva, M Mirazita, V Mokeev, A Movsisyan, C Munoz Camacho, P Nadel-Turonski, G Niculescu, S Niccolai, M Osipenko, A I Ostrovidov, M Paolone, L Pappalardo, R Paremuzyan, K Park, E Pasyuk, D Payette, W Phelps, S K Phillips, J Pierce, O Pogorelko, J Poudel, J W Price, Y Prok, D Protopopescu, B A Raue, A Rizzo, G Rosner, P Rossi, F Sabatié, C Salgado, R A Schumacher, Y G Sharabian, T Shigeyuki, A Simonyan, Iu Skorodumina, G D Smith, N Sparveris, D Sokhan, S Stepanyan, I I Strakovsky, S Strauch, V Sulkosky, M Taiuti, J A Tan, M Ungaro, E Voutier, X Wei, L B Weinstein, J Zhang, Z W Zhao
We measured the g_{1} spin structure function of the deuteron at low Q^{2}, where QCD can be approximated with chiral perturbation theory (χPT). The data cover the resonance region, up to an invariant mass of W≈1.9  GeV. The generalized Gerasimov-Drell-Hearn sum, the moment Γ_{1}^{d} and the spin polarizability γ_{0}^{d} are precisely determined down to a minimum Q^{2} of 0.02  GeV^{2} for the first time, about 2.5 times lower than that of previous data. We compare them to several χPT calculations and models...
February 9, 2018: Physical Review Letters
Howard A Burris, Ian W Flinn, Manish R Patel, Timothy S Fenske, Changchun Deng, Danielle M Brander, Martin Gutierrez, James H Essell, John G Kuhn, Hari P Miskin, Peter Sportelli, Michael S Weiss, Swaroop Vakkalanka, Michael R Savona, Owen A O'Connor
BACKGROUND: Umbralisib (TGR-1202) is a novel next-generation inhibitor of phosphatidylinositol 3-kinase (PI3K) isoform p110δ (PI3Kδ), which is structurally distinct from other PI3Kδ inhibitors and shows improved isoform selectivity. Umbralisib also uniquely inhibits casein kinase-1ε, a major regulator of protein translation. The aim of this first-in-human phase 1 study was to establish the safety and preliminary activity profile of umbralisib in patients with haematological malignancies...
February 20, 2018: Lancet Oncology
Jorrit L Opstelten, Simon S M Chan, Andrew R Hart, Fiona D M van Schaik, Peter D Siersema, Eef G W M Lentjes, Kay-Tee Khaw, Robert Luben, Timothy J Key, Heiner Boeing, Manuela M Bergmann, Kim Overvad, Domenico Palli, Giovanna Masala, Antoine Racine, Franck Carbonnel, Marie-Christine Boutron-Ruault, Anne Tjønneland, Anja Olsen, Vibeke Andersen, Rudolf Kaaks, Tilman Kühn, Rosario Tumino, Antonia Trichopoulou, Petra H M Peeters, W M Monique Verschuren, Ben J M Witteman, Bas Oldenburg
Background: A low vitamin D status has been put forward as a potential risk factor for the development of inflammatory bowel disease (IBD). This study investigated the association between prediagnostic circulating vitamin D concentrations and dietary intakes of vitamin D, and the risk of Crohn's disease (CD) and ulcerative colitis (UC). Methods: Among 359,728 participants of the European Prospective Investigation into Cancer and Nutrition cohort, individuals who developed CD or UC after enrollment were identified...
February 15, 2018: Inflammatory Bowel Diseases
Masaharu Iwasaki, Petra Minder, Yíngyún Caì, Jens H Kuhn, John R Yates, Bruce E Torbett, Juan C de la Torre
Several mammalian arenaviruses (mammarenaviruses) cause hemorrhagic fevers in humans and pose serious public health concerns in their endemic regions. Additionally, mounting evidence indicates that the worldwide-distributed, prototypic mammarenavirus, lymphocytic choriomeningitis virus (LCMV), is a neglected human pathogen of clinical significance. Concerns about human-pathogenic mammarenaviruses are exacerbated by of the lack of licensed vaccines, and current anti-mammarenavirus therapy is limited to off-label use of ribavirin that is only partially effective...
February 20, 2018: PLoS Pathogens
José Suarez Sanchez-Andrade, Henning Richter, Karolin Kuhn, Andrea S Bischofberger, Patrick R Kircher, Séamus Hoey
While articular cartilage changes are considered to be one of the initial events in the pathological cascade leading to osteoarthritis, these changes remain difficult to detect using conventional diagnostic imaging modalities such as plain radiography. The aim of this prospective, experimental, methods comparison study was to compare the sensitivity of magnetic resonance imaging (MRI), magnetic resonance arthrography, computed tomography (CT), and CT arthrography in the detection of artificially induced articular cartilage defects in the equine carpal joints...
February 18, 2018: Veterinary Radiology & Ultrasound
Kevin M Hellman, Caroline S Kuhn, Frank F Tu, Katlyn E Dillane, Nathan A Shlobin, Sangeeta Senapati, Xiaojie Zhou, Wei Li, Pottumarthi V Prasad
BACKGROUND: The lack of non-invasive methods to study dysmenorrhea has resulted in poor understanding of the mechanisms underlying pain, insufficient diagnostic tests, and limited treatment options. To address this knowledge gap, we have developed an MRI-based strategy for continuously monitoring the uterus in relation to participants' spontaneous pain perception. OBJECTIVE: The study objective was to evaluate whether MRI can detect real-time changes in myometrial activity during cramping episodes in women with dysmenorrhea, with a hand-held squeeze bulb for pain reporting...
January 31, 2018: American Journal of Obstetrics and Gynecology
Yasmine Neirijnck, Pierre Calvel, Karen R Kilcoyne, Françoise Kühne, Isabelle Stévant, Richard J Griffeth, Jean-Luc Pitetti, Silvana A Andric, Meng-Chun Hu, François Pralong, Lee B Smith, Serge Nef
The insulin family of growth factors (insulin, IGF1, and IGF2) are critical in sex determination, adrenal differentiation, and testicular function. Notably, the IGF system has been reported to mediate the proliferation of steroidogenic cells. However, the precise role and contribution of the membrane receptors mediating those effects, namely, insulin receptor (INSR) and type-I insulin-like growth factor receptor (IGF1R), have not, to our knowledge, been investigated. We show here that specific deletion of both Insr and Igf1r in steroidogenic cells in mice leads to severe alterations of adrenocortical and testicular development...
January 24, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
G Winterer, G Androsova, O Bender, D Boraschi, F Borchers, T B Dschietzig, I Feinkohl, P Fletcher, J Gallinat, D Hadzidiakos, J D Haynes, F Heppner, S Hetzer, J Hendrikse, B Ittermann, I M J Kant, A Kraft, A Krannich, R Krause, S Kühn, G Lachmann, S J T van Montfort, A Müller, P Nürnberg, K Ofosu, M Pietsch, T Pischon, J Preller, E Renzulli, K Scheurer, R Schneider, A J C Slooter, C Spies, E Stamatakis, H D Volk, S Weber, A Wolf, F Yürek, N Zacharias
Postoperative cognitive impairment is among the most common medical complications associated with surgical interventions - particularly in elderly patients. In our aging society, it is an urgent medical need to determine preoperative individual risk prediction to allow more accurate cost-benefit decisions prior to elective surgeries. So far, risk prediction is mainly based on clinical parameters. However, these parameters only give a rough estimate of the individual risk. At present, there are no molecular or neuroimaging biomarkers available to improve risk prediction and little is known about the etiology and pathophysiology of this clinical condition...
February 2, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
Morten Sales, Markus Strobl, Takenao Shinohara, Anton Tremsin, Luise Theil Kuhn, William R B Lionheart, Naeem M Desai, Anders Bjorholm Dahl, Søren Schmidt
Through the use of Time-of-Flight Three Dimensional Polarimetric Neutron Tomography (ToF 3DPNT) we have for the first time successfully demonstrated a technique capable of measuring and reconstructing three dimensional magnetic field strengths and directions unobtrusively and non-destructively with the potential to probe the interior of bulk samples which is not amenable otherwise. Using a pioneering polarimetric set-up for ToF neutron instrumentation in combination with a newly developed tailored reconstruction algorithm, the magnetic field generated by a current carrying solenoid has been measured and reconstructed, thereby providing the proof-of-principle of a technique able to reveal hitherto unobtainable information on the magnetic fields in the bulk of materials and devices, due to a high degree of penetration into many materials, including metals, and the sensitivity of neutron polarisation to magnetic fields...
February 2, 2018: Scientific Reports
Caleb R Glassman, Heather L Parrish, Mark S Lee, Michael S Kuhns
CD4+ T cells convert the time that T cell receptors (TCRs) interact with peptides embedded within class II major histocompatibility complex molecules (pMHCII) into signals that direct cell-fate decisions. In principle, TCRs relay information to intracellular signaling motifs of the associated CD3 subunits, while CD4 recruits the kinase Lck to those motifs upon coincident detection of pMHCII. But the mechanics by which this occurs remain enigmatic. In one model, the TCR and CD4 bind pMHCII independently, while in another, CD4 interacts with a composite surface formed by the TCR-CD3 complex bound to pMHCII...
January 30, 2018: Cell Reports
H M Hammon, D Frieten, C Gerbert, C Koch, G Dusel, R Weikard, C Kühn
There is increasing evidence that nutrition during early mammalian life has a strong influence on health and performance in later life. However, there are conflicting data concerning the appropriate milk diet. This discrepancy particularly applies to ruminants, a group of mammals that switch from monogastric status to rumination during weaning. Little is known regarding how the whole genome expression pattern in the juvenile ruminant gut is affected by alternative milk diets. Thus, we performed a next-generation-sequencing-based holistic whole transcriptome analysis of the jejunum in male pre-weaned German Holstein calves fed diets with restricted or unlimited access to milk during the first 8 weeks of life...
January 26, 2018: Scientific Reports
Angela Schooley, Jonathan Kuhn, Charlotte Strahm
The purpose of this study was to explore the application of path analysis to evaluate the curriculum model and provide guidance in course sequencing. Using statistical package R to add and subtract various path connections, the curriculum model was improved to a proposed curriculum model, which passed the exact-fit test (χ42 = 45.612, with P = .286 > .05). Path analysis provided an objective method to evaluate the curriculum model and course sequencing in the baccalaureate program under study, while informing possible placement of courses...
January 25, 2018: Nurse Educator
Evelien M Adriaenssens, Johannes Wittmann, Jens H Kuhn, Dann Turner, Matthew B Sullivan, Bas E Dutilh, Ho Bin Jang, Leonardo J van Zyl, Jochen Klumpp, Malgorzata Lobocka, Andrea I Moreno Switt, Janis Rumnieks, Robert A Edwards, Jumpei Uchiyama, Poliane Alfenas-Zerbini, Nicola K Petty, Andrew M Kropinski, Jakub Barylski, Annika Gillis, Martha R C Clokie, David Prangishvili, Rob Lavigne, Ramy Karam Aziz, Siobain Duffy, Mart Krupovic, Minna M Poranen, Petar Knezevic, Francois Enault, Yigang Tong, Hanna M Oksanen, J Rodney Brister
No abstract text is available yet for this article.
January 22, 2018: Archives of Virology
R William Stein, Christopher G Mull, Tyler S Kuhn, Neil C Aschliman, Lindsay N K Davidson, Jeffrey B Joy, Gordon J Smith, Nicholas K Dulvy, Arne O Mooers
In an era of accelerated biodiversity loss and limited conservation resources, systematic prioritization of species and places is essential. In terrestrial vertebrates, evolutionary distinctness has been used to identify species and locations that embody the greatest share of evolutionary history. We estimate evolutionary distinctness for a large marine vertebrate radiation on a dated taxon-complete tree for all 1,192 chondrichthyan fishes (sharks, rays and chimaeras) by augmenting a new 610-species molecular phylogeny using taxonomic constraints...
January 18, 2018: Nature Ecology & Evolution
Fredric P Manfredsson, Kelvin C Luk, Matthew J Benskey, Aysegul Guezer, Joanna Garcia, Nathan C Kuhn, Ivette M Sandoval, Joseph R Patterson, Alana O'Mara, Reid Yonkers, Jeffrey H Kordower
Alpha-Synuclein (α-syn) is by far the most highly vetted pathogenic and therapeutic target in Parkinson's disease. Aggregated α-syn is present in sporadic Parkinson's disease, both in the central nervous system (CNS) and peripheral nervous system (PNS). The enteric division of the PNS is of particular interest because 1) gastric dysfunction is a key clinical manifestation of Parkinson's disease, and 2) Lewy pathology in myenteric and submucosal neurons of the enteric nervous system (ENS) has been referred to as stage zero in the Braak pathological staging of Parkinson's disease...
January 13, 2018: Neurobiology of Disease
John T Wixted, Stephen D Goldinger, Larry R Squire, Joel R Kuhn, Megan H Papesh, Kris A Smith, David M Treiman, Peter N Steinmetz
Neurocomputational models have long posited that episodic memories in the human hippocampus are represented by sparse, stimulus-specific neural codes. A concomitant proposal is that when sparse-distributed neural assemblies become active, they suppress the activity of competing neurons (neural sharpening). We investigated episodic memory coding in the hippocampus and amygdala by measuring single-neuron responses from 20 epilepsy patients (12 female) undergoing intracranial monitoring while they completed a continuous recognition memory task...
January 30, 2018: Proceedings of the National Academy of Sciences of the United States of America
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"