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Mickaël Avanthay, Belen Batanero, Dylan G Boucher, Christoph Bondue, Pim Broersen, Richard C D Brown, Robert Francke, Toshio Fuchigami, Alexander Kuhn, Kevin Lam, Chia-Yu Lin, T Leo Liu, Long Luo, Shelley D Minteer, Kevin Moeller, Toshiki Nokami, Robert Price, Shahid Rasul, Eniola Sokalu
No abstract text is available yet for this article.
October 2, 2023: Faraday Discussions
#22
JOURNAL ARTICLE
Richard Vollenberg, Eva Ulla Lorentzen, Joachim Kühn, Tobias Max Nowacki, Jörn Arne Meier, Jonel Trebicka, Phil-Robin Tepasse
INTRODUCTION: The COVID-19 pandemic is a result of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Vaccination against COVID-19 is crucial for preventing severe illness and controlling the pandemic. This study aimed to examine how immunosuppressed patients with inflammatory bowel disease (IBD) responded to the third mRNA vaccination against SARS-CoV-2. The patients were undergoing treatments such as anti-TNF (infliximab, adalimumab), anti-α4ß7 integrin (vedolizumab), anti-IL12/23 (ustekinumab) and azathioprine (purine analog)...
August 24, 2023: Vaccines
#23
JOURNAL ARTICLE
Richard Lindtner, Alexander Wurm, Katrin Kugel, Julia Kühn, David Putzer, Rohit Arora, Débora Cristina Coraça-Huber, Philipp Zelger, Michael Schirmer, Jovan Badzoka, Christoph Kappacher, Christian Wolfgang Huck, Johannes Dominikus Pallua
Bone analyses using mid-infrared spectroscopy are gaining popularity, especially with handheld spectrometers that enable on-site testing as long as the data quality meets standards. In order to diagnose Staphylococcus epidermidis in human bone grafts, this study was carried out to compare the effectiveness of the Agilent 4300 Handheld Fourier-transform infrared with the Perkin Elmer Spectrum 100 attenuated-total-reflectance infrared spectroscopy benchtop instrument. The study analyzed 40 non-infected and 10 infected human bone samples with Staphylococcus epidermidis , collecting reflectance data between 650 cm-1 and 4000 cm-1 , with a spectral resolution of 2 cm-1 (Agilent 4300 Handheld) and 0...
August 29, 2023: Bioengineering
#24
JOURNAL ARTICLE
Zhiqing Wang, Andrei Fokine, Xinwu Guo, Wen Jiang, Michael G Rossmann, Richard J Kuhn, Zhu-Hua Luo, Thomas Klose
Antibiotic resistance poses a growing risk to public health, requiring new tools to combat pathogenic bacteria. Contractile injection systems, including bacteriophage tails, pyocins, and bacterial type VI secretion systems, can efficiently penetrate cell envelopes and become potential antibacterial agents. Bacteriophage XM1 is a dsDNA virus belonging to the Myoviridae family and infecting Vibrio bacteria. The XM1 virion, made of 18 different proteins, consists of an icosahedral head and a contractile tail, terminated with a baseplate...
July 31, 2023: Viruses
#25
JOURNAL ARTICLE
Andreas Haeberlin, Fabian Noti, Alexander Breitenstein, Angelo Auricchio, Tobias Reichlin, Giulio Conte, Catherine Klersy, Moreno Curti, Etienne Pruvot, Giulia Domenichini, Beat Schaer, Michael Kühne, Michal Gruszczynski, Haran Burri, Richard Kobza, Christian Grebmer, François D Regoli
BACKGROUND: Device patients may require upgrade interventions from simpler to more complex cardiac implantable electronic devices. Prior to upgrading interventions, clinicians need to balance the risks and benefits of transvenous lead extraction (TLE), additional lead implantation or lead abandonment. However, evidence on procedural outcomes of TLE at the time of device upgrade is scarce. METHODS: This is a post hoc analysis of the investigator-initiated multicenter Swiss TLE registry...
August 8, 2023: Journal of Clinical Medicine
#26
JOURNAL ARTICLE
Jens H Kuhn, Junya Abe, Scott Adkins, Sergey V Alkhovsky, Tatjana Avšič-Županc, María A Ayllón, Justin Bahl, Anne Balkema-Buschmann, Matthew J Ballinger, Virendra Kumar Baranwal, Martin Beer, Nicolas Bejerman, Éric Bergeron, Nadine Biedenkopf, Carol D Blair, Kim R Blasdell, Arnaud G Blouin, Steven B Bradfute, Thomas Briese, Paul A Brown, Ursula J Buchholz, Michael J Buchmeier, Alexander Bukreyev, Felicity Burt, Carmen Büttner, Charles H Calisher, Mengji Cao, Inmaculada Casas, Kartik Chandran, Rémi N Charrel, Krishna Kumar Chaturvedi, Kar Mun Chooi, Anya Crane, Elena Dal Bó, Juan Carlos de la Torre, William M de Souza, Rik L de Swart, Humberto Debat, Nolwenn M Dheilly, Nicholas Di Paola, Francesco Di Serio, Ralf G Dietzgen, Michele Digiaro, J Felix Drexler, W Paul Duprex, Ralf Dürrwald, Andrew J Easton, Toufic Elbeaino, Koray Ergünay, Guozhong Feng, Andrew E Firth, Anthony R Fooks, Pierre B H Formenty, Juliana Freitas-Astúa, Selma Gago-Zachert, María Laura García, Adolfo García-Sastre, Aura R Garrison, Thomas R Gaskin, Wenjie Gong, Jean-Paul J Gonzalez, JoëlleGoüy de Bellocq, Anthony Griffiths, Martin H Groschup, Ines Günther, Stephan Günther, John Hammond, Yusuke Hasegawa, Kazusa Hayashi, Jussi Hepojoki, Colleen M Higgins, Seiji Hongō, Masayuki Horie, Holly R Hughes, Adam J Hume, Timothy H Hyndman, Kenichi Ikeda, Dàohóng Jiāng, Gilda B Jonson, Sandra Junglen, Boris Klempa, Jonas Klingström, Hideki Kondō, Eugene V Koonin, Mart Krupovic, Kenji Kubota, Gael Kurath, Lies Laenen, Amy J Lambert, Jiànróng Lǐ, Jun-Min Li, Ran Liu, Igor S Lukashevich, Robin M MacDiarmid, Piet Maes, Marco Marklewitz, Sergio H Marshall, Shin-Yi L Marzano, John W McCauley, Ali Mirazimi, Elke Mühlberger, Tomoyuki Nabeshima, Rayapati Naidu, Tomohide Natsuaki, Beatriz Navarro, José A Navarro, Yutaro Neriya, Sergey V Netesov, Gabriele Neumann, Norbert Nowotny, Márcio R T Nunes, Francisco M Ochoa-Corona, Tomoyuki Okada, Gustavo Palacios, Vicente Pallás, Anna Papa, Sofia Paraskevopoulou, Colin R Parrish, Alex Pauvolid-Corrêa, Janusz T Pawęska, Daniel R Pérez, Florian Pfaff, Richard K Plemper, Thomas S Postler, Lee O Rabbidge, Sheli R Radoshitzky, Pedro L Ramos-González, Marius Rehanek, Renato O Resende, Carina A Reyes, Thaís C S Rodrigues, Víctor Romanowski, Dennis Rubbenstroth, Luisa Rubino, Jonathan A Runstadler, Sead Sabanadzovic, Sabrina Sadiq, Maria S Salvato, Takahide Sasaya, Martin Schwemmle, Stephen R Sharpe, Mang Shi, Yoshifumi Shimomoto, Venkidusamy Kavi Sidharthan, Manuela Sironi, Sophie Smither, Jin-Won Song, Kirsten M Spann, Jessica R Spengler, Mark D Stenglein, Ayato Takada, Sawana Takeyama, Akio Tatara, Robert B Tesh, Natalie J Thornburg, Xin Tian, Nicole D Tischler, Yasuhiro Tomitaka, Keizō Tomonaga, Noël Tordo, Changchun Tu, Massimo Turina, Ioannis E Tzanetakis, Anna Maria Vaira, Bernadette van den Hoogen, Bert Vanmechelen, Nikos Vasilakis, Martin Verbeek, Susanne von Bargen, Jiro Wada, Victoria Wahl, Peter J Walker, Thomas B Waltzek, Anna E Whitfield, Yuri I Wolf, Han Xia, Evanthia Xylogianni, Hironobu Yanagisawa, Kazutaka Yano, Gongyin Ye, Zhiming Yuan, F Murilo Zerbini, Guilin Zhang, Song Zhang, Yong-Zhen Zhang, Lu Zhao, Arnfinn Lodden Økland
In April 2023, following the annual International Committee on Taxonomy of Viruses (ICTV) ratification vote on newly proposed taxa, the phylum Negarnaviricota was amended and emended. The phylum was expanded by one new family, 14 new genera, and 140 new species. Two genera and 538 species were renamed. One species was moved, and four were abolished. This article presents the updated taxonomy of Negarnaviricota as now accepted by the ICTV.
August 2023: Journal of General Virology
#27
JOURNAL ARTICLE
Annina Stauber, Andreas Müller, Nikki Rommers, Stefanie Aeschbacher, Nicolas Rodondi, Leo H Bonati, Juerg H Beer, Raban V Jeger, David J Kurz, Claudia Liedtke, Peter Ammann, Marcello Di Valentino, Patricia Chocano, Richard Kobza, Michael Kühne, David Conen, Stefan Osswald, Alain M Bernheim
AIM: To assess the associations of chocolate consumption with neurocognitive function, brain lesions on magnetic resonance imaging (MRI), and cardiovascular outcome in patients with atrial fibrillation (AF). METHODS: We analysed data from patients of two prospective multicentre Swiss atrial fibrillation cohort studies (Swiss-AF) and (BEAT-AF). Assessments of MRI findings and neurocognitive function were performed only in the Swiss-AF population (in 1727 of 2415 patients [71...
August 23, 2023: Swiss Medical Weekly
#28
JOURNAL ARTICLE
Jessica Richards, Benjamin F Henwood, Natalie Porter, Randall Kuhn
PURPOSE: We examined the impact of duration and number of homelessness episodes on health outcomes for unsheltered homeless young adults. METHODS: We analyzed the 2018/2019 Los Angeles County homeless youth demographic surveys. We addressed five summary health outcomes: physical health, mental health, substance use disorder, tri-morbidity, and any condition. Respondents were classified into three homeless trajectory groups: (1) short-term-homeless < 1 year in one episode, (2) episodic-homeless < 1 year and multiple episodes, and (3) long-term-homeless continuously for > 1 year...
August 12, 2023: Journal of Adolescent Health
#29
REVIEW
Zachary D Randall, Aravinda Ganapathy, Andrew W Kuhn, Richard M Silverman, Paul M Inclan, Alexander W Aleem
UNLABELLED: COVID-19 forced surgical resident training programs to adapt to meet educational requirements within the constraints of various guidelines. Some of the changes implemented during the pandemic have imparted a lasting effect on orthopaedic education. As such, the purpose of this article was to review how orthopaedic training and education were affected during the COVID-19 pandemic. METHODS: The published literature was queried using search strategies devised by a medical librarian, according to the Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines...
2023: JB & JS Open Access
#30
JOURNAL ARTICLE
Jürgen M Steinacker, Willem van Mechelen, Wilhelm Bloch, Mats Börjesson, Maurizio Casasco, Bernd Wolfarth, Carolin Knoke, Theodora Papadopoulou, Janine Wendt, Hashel Al Tunaiji, Dietrich Andresen, Olena Andrieieva, Norbert Bachl, Victoriya Badtieva, Friedhelm J Beucher, Cheri A Blauwet, Jose-Antonio Casajus Mallen, Ju-Ho Chang, German Clénin, Naama Constantini, Demitri Constantinou, Luigi Di Luigi, Lukas Declercq, Stephane Doutreleau, Svitlana Drozdovska, Martine Duclos, Andrea Ermolao, Thomas Fischbach, Anastasia N Fischer, Chiara Fossati, Jeorge Franchella, Mark Fulcher, Jan C Galle, Christian Gerloff, Evelina Georgiades, Boris Gojanovic, Marcela González Gross, Andy Grote, Martin Halle, Hans Hauner, Matthew Payton Herring, Mikio Hiura, Kerstin Holze, Gerhard Huber, David Hughes, Mark R Hutchinson, Anca Ionescu, Dina Christina Janse van Rensburg, Anna Jegier, Natasha Jones, Kirsten Kappert-Gonther, Monika Kellerer, Yutaka Kimura, Agrita Kiopa, Bernd Kladny, Gerhard Koch, Elin Kolle, Greg Kolt, Yiannis Koutedakis, Stephan Kress, Susi Kriemler, Jens Kröger, Christian Kuhn, Roman Laszlo, Ralph Lehnert, François J Lhuissier, Kerstin Lüdtke, Shigeru Makita, Pedro Manonelles Marqueta, Winfried März, Kirill Micallef-Stafrace, Mike Miller, Melita Moore, Erich Müller, Daniel Neunhäuserer, I Renay Onur, Vahur Ööpik, Malgorzata Perl, Anastassios Philippou, Hans-Georg Predel, Sebastien Racinais, Algirdas Raslanas, Ruediger Reer, Klaus Reinhardt, Claus Reinsberger, Sandra Rozenstoka, Robert Sallis, Luis B Sardinha, Martin Scherer, Jasper Schipperijn, Romain Seil, Benedict Tan, Arno Schmidt-Trucksäss, Nils Schumacher, Bernhard Schwaab, Ansgar Schwirtz, Masato Suzuki, Jeroen Swart, Ralph Tiesler, Ulf Tippelt, Eleanor Tillet, Jane Thornton, Bulent Ulkar, Eve Unt, Evert Verhagen, Thomas Weikert, Roberto Vettor, Sheng Zeng, Richard Budgett, Lars Engebretsen, Ugur Erdener, Fabio Pigozzi, Yannis P Pitsiladis
Non-communicable diseases (NCDs), including coronary heart disease, stroke, hypertension, type 2 diabetes, dementia, depression and cancers, are on the rise worldwide and are often associated with a lack of physical activity (PA). Globally, the levels of PA among individuals are below WHO recommendations. A lack of PA can increase morbidity and mortality, worsen the quality of life and increase the economic burden on individuals and society. In response to this trend, numerous organisations came together under one umbrella in Hamburg, Germany, in April 2021 and signed the 'Hamburg Declaration'...
2023: BMJ Open Sport & Exercise Medicine
#31
JOURNAL ARTICLE
S Diehl, N Trotta, K Joo, P Achenbach, Z Akbar, W R Armstrong, H Atac, H Avakian, L Baashen, N A Baltzell, L Barion, M Bashkanov, M Battaglieri, I Bedlinskiy, F Benmokhtar, A Bianconi, A S Biselli, F Bossù, K-T Brinkmann, W J Briscoe, D Bulumulla, V Burkert, R Capobianco, D S Carman, J C Carvajal, A Celentano, G Charles, P Chatagnon, V Chesnokov, G Ciullo, P L Cole, M Contalbrigo, G Costantini, V Crede, A D'Angelo, N Dashyan, R De Vita, A Deur, C Djalali, R Dupre, M Ehrhart, A El Alaoui, L El Fassi, L Elouadrhiri, S Fegan, A Filippi, G Gavalian, D I Glazier, A A Golubenko, G Gosta, R W Gothe, Y Gotra, K Griffioen, K Hafidi, H Hakobyan, M Hattawy, T B Hayward, D Heddle, A Hobart, M Holtrop, I Illari, D G Ireland, E L Isupov, H S Jo, R Johnston, D Keller, M Khachatryan, A Khanal, A Kim, W Kim, V Klimenko, A Kripko, V Kubarovsky, S E Kuhn, V Lagerquist, L Lanza, M Leali, S Lee, P Lenisa, X Li, I J D MacGregor, D Marchand, V Mascagna, G Matousek, B McKinnon, C McLauchlin, Z E Meziani, S Migliorati, R G Milner, T Mineeva, M Mirazita, V Mokeev, P Moran, C Munoz Camacho, P Naidoo, K Neupane, S Niccolai, G Niculescu, M Osipenko, P Pandey, M Paolone, L L Pappalardo, R Paremuzyan, S J Paul, W Phelps, N Pilleux, M Pokhrel, J Poudel, J W Price, Y Prok, A Radic, B A Raue, T Reed, J Richards, M Ripani, J Ritman, P Rossi, F Sabatié, C Salgado, S Schadmand, A Schmidt, Y G Sharabian, U Shrestha, D Sokhan, N Sparveris, M Spreafico, S Stepanyan, I Strakovsky, S Strauch, M Turisini, R Tyson, M Ungaro, S Vallarino, L Venturelli, H Voskanyan, E Voutier, D P Watts, X Wei, R Williams, R Wishart, M H Wood, M Yurov, N Zachariou, Z W Zhao, M Zurek
The polarized cross-section ratio σ_{LT^{'}}/σ_{0} from hard exclusive π^{-}Δ^{++} electroproduction off an unpolarized hydrogen target has been extracted based on beam-spin asymmetry measurements using a 10.2 GeV/10.6 GeV incident electron beam and the CLAS12 spectrometer at Jefferson Lab. The study, which provides the first observation of this channel in the deep-inelastic regime, focuses on very forward-pion kinematics in the valence regime, and photon virtualities ranging from 1...
July 14, 2023: Physical Review Letters
#32
JOURNAL ARTICLE
Sara Alehashemi, Surendra Dasari, Anvitha Metpally, Kat Uss, Leslie A Castelo-Soccio, Theo Heller, Peter Kellman, Marcus Y Chen, Mark Ahlman, Jeff Kim, Susannah Wargo, Douglas B Kuhns, Danielle Fink, Adriana de Jesus, Paul S Martin, Richard Chang, Jonathan Bolanos, Chyi-Chia Richard Lee, Samih H Nasr, Raphaela Goldbach-Mansky, Ellen McPhail
OBJECTIVE: To describe a 41-year-old woman with a history of Neonatal onset multisystem inflammatory disease (NOMID), on treatment with daily subcutaneous injections of 600 mg of recombinant IL1RA (Interleukin-1 receptor antagonist protein), anakinra, since the age of 28, who presented with golf-ball size nodules at the anakinra injection sites, early satiety, new onset nephrotic syndrome in the context of normal markers of systemic inflammation. METHODS: Clinical history and histologic evaluation of biopsies of skin, gastric mucosa, and kidney with Congo-Red staining and proteomic evaluation of microdissected Congo Red-positive amyloid deposits by liquid chromatography-tandem mass spectrometry...
July 24, 2023: Arthritis & Rheumatology
#33
REVIEW
Tim J Patterson, David McKinney, Jonathan Ritson, Chris McLean, Weidong Gu, Marcus Colyer, Scott F McClellan, Sarah C Miller, Grant A Justin, Annette K Hoskin, Kara Cavuoto, James Leong, Andrés Rousselot Ascarza, Fasika A Woreta, Kyle E Miller, Matthew C Caldwell, William G Gensheimer, Tom Williamson, Felipe Dhawahir-Scala, Peter Shah, Andrew Coombes, Gangadhara Sundar, Robert A Mazzoli, Malcolm Woodcock, Ferenc Kuhn, Stephanie L Watson, Renata S M Gomes, Rupesh Agrawal, Richard J Blanch
TOPIC: This study reports the effect of systemic prophylactic antibiotics (and their route) on the risk of endophthalmitis after open globe injury. CLINICAL RELEVANCE: Endophthalmitis is a major complication of open globe injury, it can lead to rapid sight loss in the affected eye. The administration of systemic antibiotic prophylaxis is common practice in some health care systems, although there is no consensus on their use. METHODS: PubMed, CENTRAL, Web of Science, CINAHL and Embase were searched...
July 3, 2023: Ophthalmology Retina
#34
JOURNAL ARTICLE
Simon Martin Frey, Roman Brenner, Dominic A Theuns, Naeem Al-Shoaibi, Richard J Crawley, Peter Ammann, Christian Sticherling, Michael Kühne, Stefan Osswald, Beat Schaer
BACKGROUND: Some patients with cardiac resynchronisation therapy (CRT) experience super-response (LVEF improvements to ≥50%). At generator exchange (GE), downgrading (DG) from CRT-defibrillator (CRT-D) to CRT-pacemaker (CRT-P) could be an option for these patients on primary prevention ICD indication and no required ICD therapies. Long-term data on arrhythmic events in super-responders is scarce. METHODS: CRT-D patients with LVEF improvement to ≥50% at GE were identified in four large centres for retrospective analysis...
2023: Frontiers in Cardiovascular Medicine
#35
JOURNAL ARTICLE
Thomas R Lane, Jianing Fu, Barbara Sherry, Bart Tarbet, Brett L Hurst, Olga Riabova, Elena Kazakova, Anna Egorova, Penny Clarke, J Smith Leser, Joshua Frost, Michael Rudy, Ken Tyler, Thomas Klose, Alexandrina S Volobueva, Svetlana V Belyaevskaya, Vladimir V Zarubaev, Richard J Kuhn, Vadim Makarov, Sean Ekins
Enteroviruses (EV) cause a number of life-threatening infectious diseases. EV-D68 is known to cause respiratory illness in children that can lead to acute flaccid myelitis. Coxsackievirus B5 (CVB5) is commonly associated with hand-foot-mouth disease. There is no antiviral treatment available for either. We have developed an isoxazole-3-carboxamide analog of pleconaril (11526092) which displayed potent inhibition of EV-D68 (IC50 58 nM) as well as other enteroviruses including the pleconaril-resistant Coxsackievirus B3-Woodruff (IC50 6-20 nM) and CVB5 (EC50 1 nM)...
June 14, 2023: Antiviral Research
#36
JOURNAL ARTICLE
G Christiaens, M Defurne, D Sokhan, P Achenbach, Z Akbar, M J Amaryan, H Atac, H Avakian, C Ayerbe Gayoso, L Baashen, N A Baltzell, L Barion, M Bashkanov, M Battaglieri, I Bedlinskiy, B Benkel, F Benmokhtar, A Bianconi, A S Biselli, M Bondi, W A Booth, F Bossù, S Boiarinov, K-Th Brinkmann, W J Briscoe, S Bueltmann, D Bulumulla, V D Burkert, T Cao, D S Carman, J C Carvajal, A Celentano, P Chatagnon, V Chesnokov, T Chetry, G Ciullo, G Clash, P L Cole, M Contalbrigo, G Costantini, A D'Angelo, N Dashyan, R De Vita, A Deur, S Diehl, C Dilks, C Djalali, R Dupre, H Egiyan, M Ehrhart, A El Alaoui, L El Fassi, L Elouadrhiri, S Fegan, A Filippi, K Gates, G Gavalian, Y Ghandilyan, G P Gilfoyle, F X Girod, D I Glazier, A A Golubenko, G Gosta, R W Gothe, Y Gotra, K A Griffioen, M Guidal, K Hafidi, H Hakobyan, M Hattawy, F Hauenstein, T B Hayward, D Heddle, A Hobart, D E Holmberg, M Holtrop, Y Ilieva, D G Ireland, E L Isupov, H S Jo, D Keller, M Khachatryan, A Khanal, W Kim, A Kripko, V Kubarovsky, S E Kuhn, V Lagerquist, L Lanza, M L Kabir, M Leali, S Lee, P Lenisa, X Li, K Livingston, I J D MacGregor, D Marchand, V Mascagna, G Matousek, B McKinnon, C McLauchlin, Z E Meziani, S Migliorati, R G Milner, T Mineeva, M Mirazita, V Mokeev, E Molina, C Munoz Camacho, P Nadel-Turonski, P Naidoo, K Neupane, S Niccolai, M Nicol, G Niculescu, M Osipenko, M Ouillon, P Pandey, M Paolone, L L Pappalardo, R Paremuzyan, E Pasyuk, S J Paul, W Phelps, N Pilleux, M Pokhrel, J Poudel, J W Price, Y Prok, A Radic, N Ramasubramanian, B A Raue, Trevor Reed, J Richards, M Ripani, J Ritman, P Rossi, F Sabatié, C Salgado, S Schadmand, A Schmidt, M B C Scott, Y G Sharabian, E V Shirokov, U Shrestha, P Simmerling, N Sparveris, M Spreafico, S Stepanyan, I I Strakovsky, S Strauch, J A Tan, N Trotta, M Turisini, R Tyson, M Ungaro, S Vallarino, L Venturelli, H Voskanyan, E Voutier, D P Watts, X Wei, R Williams, R Wishart, M H Wood, N Zachariou, J Zhang, Z W Zhao, V Ziegler, M Zurek
Deeply virtual Compton scattering (DVCS) allows one to probe generalized parton distributions describing the 3D structure of the nucleon. We report the first measurement of the DVCS beam-spin asymmetry using the CLAS12 spectrometer with a 10.2 and 10.6 GeV electron beam scattering from unpolarized protons. The results greatly extend the Q^{2} and Bjorken-x phase space beyond the existing data in the valence region and provide 1600 new data points measured with unprecedented statistical uncertainty, setting new, tight constraints for future phenomenological studies...
May 26, 2023: Physical Review Letters
#37
Rupak Shivakoti, Barbara Laughton, Mehr Shafiq, Elisma Schoeman, Richard H Glashoff, Shaun Barnabas, Samantha Fry, Cheng-Shiun Leu, Shuang Wang, Lars Bode, Grace Aldrovandi, Louise Kuhn, Amy L Slogrove
Background Children who are HIV-exposed uninfected (HEU), i.e., born to mothers living with HIV despite not acquiring HIV infection themselves, have increased morbidity and mortality. Data suggests that the breastmilk profile, and more specifically human milk oligosaccharide (HMO) composition, differ by maternal HIV status and may partly help explain this increased risk. We are currently conducting an HMO-based synbiotic randomized trial in breastfed children HEU, the MIGH-T MO study (ClinicalTrials.gov Identifier: NCT05282485), to assess the impact on health outcomes of children HEU...
May 15, 2023: Research Square
#38
JOURNAL ARTICLE
Mazdak Salavati, Richard Clark, Doreen Becker, Christa Kühn, Graham Plastow, Sébastien Dupont, Gabriel Costa Monteiro Moreira, Carole Charlier, Emily Louise Clark
Understanding the genomic control of tissue-specific gene expression and regulation can help to inform the application of genomic technologies in farm animal breeding programs. The fine mapping of promoters (transcription start sites (TSS)) and enhancers (divergent amplifying segments of the genome local to TSS) in different populations of cattle across a wide diversity of tissues provides information to locate and understand the genomic drivers of breed- and tissue-specific characteristics. To this aim we used Cap Analysis Gene Expression (CAGE) sequencing, of 24 different tissues from three populations of cattle, to define TSS and their co-expressed short-range enhancers (<1 kb) in the ARS-UCD1...
May 22, 2023: G3: Genes—Genomes—Genetics
#39
RANDOMIZED CONTROLLED TRIAL
Hartmut Döhner, Daniela Weber, Julia Krzykalla, Walter Fiedler, Michael W M Kühn, Thomas Schroeder, Karin Mayer, Michael Lübbert, Mohammed Wattad, Katharina Götze, Lars Fransecky, Elisabeth Koller, Gerald Wulf, Jan Schleicher, Mark Ringhoffer, Richard Greil, Bernd Hertenstein, Jürgen Krauter, Uwe M Martens, David Nachbaur, Maisun Abu Samra, Sigrid Machherndl-Spandl, Nadezda Basara, Claudia Leis, Anika Schrade, Silke Kapp-Schwoerer, Sibylle Cocciardi, Lars Bullinger, Felicitas Thol, Michael Heuser, Peter Paschka, Verena I Gaidzik, Maral Saadati, Axel Benner, Richard F Schlenk, Konstanze Döhner, Arnold Ganser
BACKGROUND: Acute myeloid leukaemia with mutated NPM1 is associated with high CD33 expression and intermediate-risk cytogenetics. The aim of this study was to evaluate intensive chemotherapy with or without the anti-CD33 antibody-drug conjugate gemtuzumab ozogamicin in participants with newly diagnosed, NPM1-mutated acute myeloid leukaemia. METHODS: This open-label, phase 3 trial was conducted at 56 hospitals in Germany and Austria. Eligible participants were 18 years or older and had newly diagnosed NPM1-mutated acute myeloid leukaemia and an Eastern Cooperative Oncology Group performance status of 0-2...
July 2023: Lancet Haematology
#40
JOURNAL ARTICLE
Roland Richard Tilz, Vanessa Schmidt, Helmut Pürerfellner, Philippe Maury, K R J Ulian Chun, Martin Martinek, Christian Sohns, Boris Schmidt, Franck Mandel, Estelle Gandjbakhch, Mikael Laredo, Melanie Anuscha Gunawardene, Stephan Willems, Thomas Beiert, Martin Borlich, Leon Iden, Anna Füting, Raphael Spittler, Thomas Gaspar, Sergio Richter, Anja Schade, Malte Kuniss, Thomas Neumann, Alexander Francke, Carsten Wunderlich, Dong-In Shin, Dirk Grosse Meininghaus, Mike Foresti, Marc Bonsels, David Reek, Uwe Wiegand, Alexander Bauer, Andreas Metzner, Lars Eckardt, Sorin Ștefan Popescu, Olaf Krahnefeld, Christian Sticherling, Michael Kühne, Dinh Quang Nguyen, Laurent Roten, Ardan M Saguner, Dominik Linz, Pepijn van der Voort, Bart A Mulder, Johan Vijgen, Alexandre Almorad, Charles Guenancia, Laurent Fauchier, Serge Boveda, Y De Greef, Antoine Da Costa, Pierre Jais, Nicolas Derval, Antoine Milhem, Laurence Jesel, Rodrigue Garcia, Hervé Poty, Ziad Khoueiry, Julien Seitz, Julien Laborderie, Alexis Mechulan, Francois Brigadeau, Alexandre Zhao, Yannick Saludas, Olivier Piot, Nikhil Ahluwalia, Claire Martin, Jian Chen, Bor Antolic, Georgios Leventopoulos, Emin Evren Özcan, Hikmet Yorgun, Serkan Cay, Kivanc Yalin, Maichel Sobhy Botros, Ahmed Taher Mahmoud, Ewa Jędrzejczyk-Patej, Osamu Inaba, Ken Okumura, Koichiro Ejima, Houman Khakpour, Noel Boyle, John N Catanzaro, Vivek Reddy, Sanghamitra Mohanty, Andrea Natale, Hermann Blessberger, Bing Yang, Irene Stevens, Philipp Sommer, Christian Veltmann, Daniel Steven, Julia Vogler, Karl-Heinz Kuck, José Luis Merino, Ahmad Keelani, Christian-H Heeger
AIMS: Oesophageal fistula represents a rare but dreadful complication of atrial fibrillation catheter ablation. Data on its incidence, management, and outcome are sparse. METHODS AND RESULTS: This international multicentre registry investigates the characteristics of oesophageal fistulae after treatment of atrial fibrillation by catheter ablation. A total of 553 729 catheter ablation procedures (radiofrequency: 62.9%, cryoballoon: 36.2%, other modalities: 0.9%) were performed, at 214 centres in 35 countries...
July 14, 2023: European Heart Journal
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