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JOURNAL ARTICLE
Ahmed S Abdel-Moneim, Modra Murovska, Maria Söderlund-Venermo, Vikram N Vakharia, William C Wilson, Douglas P Gladue, Matthew D Moore, Covadonga Alonso, Sayed F Abdelwahab, Marietjie Venter, Yashpal S Malik, Shi Zhengli, Shailendra K Saxena, Anupam Varma, Richard J Kuhn
The Second International Conference of the World Society for Virology (WSV), hosted by Riga Stradiņš University, was held in Riga, Latvia, on June 15-17th, 2023. It prominently highlighted the recent advancements in different disciplines of virology. The conference had fourteen keynote speakers covering diverse topics, including emerging virus pseudotypes, Zika virus vaccine development, herpesvirus capsid mobility, parvovirus invasion strategies, influenza in animals and birds, West Nile virus and Marburg virus ecology, as well as the latest update in animal vaccines...
March 15, 2024: Virology
#2
REVIEW
Andrew W Kuhn, Justin K Yu, Katherine M Gerull, Richard M Silverman, Alexander W Aleem
BACKGROUND: The demonstrated benefits of virtual reality (VR) in orthopaedic surgical training are numerous. However, it is relatively unknown how best to implement VR into an already established orthopaedic resident education curriculum and how trainees will engage and use these technologies longitudinally. METHODS: This was an exploratory, qualitative research study performed in accordance with Consolidated Criteria for Reporting Qualitative Research guidelines...
2024: JB & JS Open Access
#3
JOURNAL ARTICLE
A Cole Burton, Christopher Beirne, Kaitlyn M Gaynor, Catherine Sun, Alys Granados, Maximilian L Allen, Jesse M Alston, Guilherme C Alvarenga, Francisco Samuel Álvarez Calderón, Zachary Amir, Christine Anhalt-Depies, Cara Appel, Stephanny Arroyo-Arce, Guy Balme, Avi Bar-Massada, Daniele Barcelos, Evan Barr, Erika L Barthelmess, Carolina Baruzzi, Sayantani M Basak, Natalie Beenaerts, Jonathan Belmaker, Olgirda Belova, Branko Bezarević, Tori Bird, Daniel A Bogan, Neda Bogdanović, Andy Boyce, Mark Boyce, LaRoy Brandt, Jedediah F Brodie, Jarred Brooke, Jakub W Bubnicki, Francesca Cagnacci, Benjamin Scott Carr, João Carvalho, Jim Casaer, Rok Černe, Ron Chen, Emily Chow, Marcin Churski, Connor Cincotta, Duško Ćirović, T D Coates, Justin Compton, Courtney Coon, Michael V Cove, Anthony P Crupi, Simone Dal Farra, Andrea K Darracq, Miranda Davis, Kimberly Dawe, Valerie De Waele, Esther Descalzo, Tom A Diserens, Jakub Drimaj, Martin Duľa, Susan Ellis-Felege, Caroline Ellison, Alper Ertürk, Jean Fantle-Lepczyk, Jorie Favreau, Mitch Fennell, Pablo Ferreras, Francesco Ferretti, Christian Fiderer, Laura Finnegan, Jason T Fisher, M Caitlin Fisher-Reid, Elizabeth A Flaherty, Urša Fležar, Jiří Flousek, Jennifer M Foca, Adam Ford, Barbara Franzetti, Sandra Frey, Sarah Fritts, Šárka Frýbová, Brett Furnas, Brian Gerber, Hayley M Geyle, Diego G Giménez, Anthony J Giordano, Tomislav Gomercic, Matthew E Gompper, Diogo Maia Gräbin, Morgan Gray, Austin Green, Robert Hagen, Robert Bob Hagen, Steven Hammerich, Catharine Hanekom, Christopher Hansen, Steven Hasstedt, Mark Hebblewhite, Marco Heurich, Tim R Hofmeester, Tru Hubbard, David Jachowski, Patrick A Jansen, Kodi Jo Jaspers, Alex Jensen, Mark Jordan, Mariane C Kaizer, Marcella J Kelly, Michel T Kohl, Stephanie Kramer-Schadt, Miha Krofel, Andrea Krug, Kellie M Kuhn, Dries P J Kuijper, Erin K Kuprewicz, Josip Kusak, Miroslav Kutal, Diana J R Lafferty, Summer LaRose, Marcus Lashley, Richard Lathrop, Thomas E Lee, Christopher Lepczyk, Damon B Lesmeister, Alain Licoppe, Marco Linnell, Jan Loch, Robert Long, Robert C Lonsinger, Julie Louvrier, Matthew Scott Luskin, Paula MacKay, Sean Maher, Benoît Manet, Gareth K H Mann, Andrew J Marshall, David Mason, Zara McDonald, Tracy McKay, William J McShea, Matt Mechler, Claude Miaud, Joshua J Millspaugh, Claudio M Monteza-Moreno, Dario Moreira-Arce, Kayleigh Mullen, Christopher Nagy, Robin Naidoo, Itai Namir, Carrie Nelson, Brian O'Neill, M Teague O'Mara, Valentina Oberosler, Christian Osorio, Federico Ossi, Pablo Palencia, Kimberly Pearson, Luca Pedrotti, Charles E Pekins, Mary Pendergast, Fernando F Pinho, Radim Plhal, Xochilt Pocasangre-Orellana, Melissa Price, Michael Procko, Mike D Proctor, Emiliano Esterci Ramalho, Nathan Ranc, Slaven Reljic, Katie Remine, Michael Rentz, Ronald Revord, Rafael Reyna-Hurtado, Derek Risch, Euan G Ritchie, Andrea Romero, Christopher Rota, Francesco Rovero, Helen Rowe, Christian Rutz, Marco Salvatori, Derek Sandow, Christopher M Schalk, Jenna Scherger, Jan Schipper, Daniel G Scognamillo, Çağan H Şekercioğlu, Paola Semenzato, Jennifer Sevin, Hila Shamon, Catherine Shier, Eduardo A Silva-Rodríguez, Magda Sindicic, Lucy K Smyth, Anil Soyumert, Tiffany Sprague, Colleen Cassady St Clair, Jennifer Stenglein, Philip A Stephens, Kinga Magdalena Stępniak, Michael Stevens, Cassondra Stevenson, Bálint Ternyik, Ian Thomson, Rita T Torres, Joan Tremblay, Tomas Urrutia, Jean-Pierre Vacher, Darcy Visscher, Stephen L Webb, Julian Weber, Katherine C B Weiss, Laura S Whipple, Christopher A Whittier, Jesse Whittington, Izabela Wierzbowska, Martin Wikelski, Jacque Williamson, Christopher C Wilmers, Todd Windle, Heiko U Wittmer, Yuri Zharikov, Adam Zorn, Roland Kays
Wildlife must adapt to human presence to survive in the Anthropocene, so it is critical to understand species responses to humans in different contexts. We used camera trapping as a lens to view mammal responses to changes in human activity during the COVID-19 pandemic. Across 163 species sampled in 102 projects around the world, changes in the amount and timing of animal activity varied widely. Under higher human activity, mammals were less active in undeveloped areas but unexpectedly more active in developed areas while exhibiting greater nocturnality...
March 18, 2024: Nature Ecology & Evolution
#4
JOURNAL ARTICLE
Uta Sekanina, Britta Tetzlaff, Ana Mazur, Tilman Huckle, Anja Kühn, Richard Dano, Carolin Höckelmann, Martin Scherer, Katrin Balzer, Sascha Köpke, Eva Hummers, Christiane Müller
BACKGROUND: About one million people in need of home care in Germany are assisted by 15,400 home care services. Home healthcare is mostly a complex endeavour because interprofessional collaboration is often challenging. This might negatively impact patient safety. The project interprof HOME aims to develop an interprofessional person-centred care concept for people receiving home care in a multistep approach. In one of the work packages we explored how people receiving home care, relatives, nurses, general practitioners, and therapists (physiotherapists, occupational therapists, and speech therapists) perceive collaboration in this setting...
March 4, 2024: BMC Prim Care
#5
JOURNAL ARTICLE
Nichole Reisdorph, Katrina Doenges, Cassandra Levens, Jon Manke, Michael Armstrong, Harry Smith, Kevin Quinn, Richard Radcliffe, Richard Reisdorph, Laura Saba, Kristine A Kuhn
BACKGROUND: While the use of orally consumed Cannabis, cannabidiol (CBD) and tetrahydrocannabinol (THC) containing products, i.e. "edibles", has expanded, the health consequences are still largely unknown. This study examines the effects of oral consumption of whole Cannabis and a complex Cannabis extract on neurochemicals, endocannabinoids (eCB), and physiological parameters (body temperature, heart rate) in mice. METHODS: In this pilot study, C57BL/6 J mice were treated with one of the following every other day for 2 weeks: a complex Cannabis extract by gavage, whole Cannabis mixed with nutritional gel through free feeding, or purified THC/CBD by intraperitoneal (i...
March 2, 2024: Journal of cannabis research
#6
JOURNAL ARTICLE
Johannes L Busch, Jonathan Kaplan, JeroenG V Habets, Lucia K Feldmann, Jan Roediger, Richard M Köhler, Timon Merk, Katharina Faust, Gerd-Helge Schneider, Hagai Bergman, Wolf-Julian Neumann, Andrea A Kühn
BACKGROUND: Deep brain stimulation (DBS) is an invasive treatment option for patients with Parkinson's disease. Recently, adaptive DBS (aDBS) systems have been developed, which adjust stimulation timing and amplitude in real-time. However, it is unknown how changes in parameters, movement states and the controllability of subthalamic beta activity affect aDBS performance. OBJECTIVE: To characterize how parameter choice, movement state and controllability interactively affect the electrophysiological and behavioral response to single threshold aDBS...
January 22, 2024: Brain Stimulation
#7
JOURNAL ARTICLE
Michele Tomasicchio, Shameem Jaumdally, Lindsay Wilson, Andrea Kotze, Lynn Semple, Stuart Meier, Anil Pooran, Aliasgar Esmail, Komala Pillay, Riyaadh Roberts, Raymond Kriel, Richard Meldau, Suzette Oelofse, Carley Mandviwala, Jessica Burns, Rolanda Londt, Malika Davids, Charnay van der Merwe, Aqeedah Roomaney, Louié Kühn, Tahlia Perumal, Alex J Scott, Martin J Hale, Vicky Baillie, Sana Mahtab, Carolyn Williamson, Rageema Joseph, Alex Sigal, Ivan Joubert, Jenna Piercy, David Thomson, David L Fredericks, Malcolm Ga Miller, Marta C Nunes, Shabir A Madhi, Keertan Dheda
RATIONALE: In the upper respiratory tract replicating (culturable) SARS-CoV-2 is recoverable for ~ 4 to 8 days after symptom onset, however, there is paucity of data about the frequency or duration of replicating virus in the lower respiratory tract (i.e. the human lung). OBJECTIVES: We undertook lung tissue sampling (needle biopsy), shortly after death, in 42 mechanically ventilated decedents during the Beta and Delta waves. An independent group of 18 ambulatory patents served as a control group...
January 16, 2024: American Journal of Respiratory and Critical Care Medicine
#8
JOURNAL ARTICLE
Stephen P H Alexander, Doriano Fabbro, Eamonn Kelly, Alistair A Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Jamie A Davies, Annie Beuve, Peter Brouckaert, Clare Bryant, John C Burnett, Richard W Farndale, Andreas Friebe, John Garthwaite, Adrian J Hobbs, Gavin E Jarvis, Doris Koesling, Michaela Kuhn, David MacEwan, Tom P Monie, Lincoln R Potter, Michael Russwurm, Harald H H W Schmidt, Johannes-Peter Stasch, Scott A Waldman
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and nearly 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (https://www.guidetopharmacology.org/), which provides more detailed views of target and ligand properties...
October 2023: British Journal of Pharmacology
#9
REVIEW
Tim J Patterson, Adam Kedzierski, David McKinney, Jonathan Ritson, Chris McLean, Weidong Gu, Marcus Colyer, Scott F McClellan, Sarah C Miller, Grant A Justin, Annette K Hoskin, Kara Cavuoto, James Leong, Andrés Rousselot Ascarza, Fasika A Woreta, Kyle E Miller, Matthew C Caldwell, William G Gensheimer, Tom Williamson, Felipe Dhawahir-Scala, Peter Shah, Andrew Coombes, Gangadhara Sundar, Robert A Mazzoli, Malcolm Woodcock, Stephanie L Watson, Ferenc Kuhn, Sophia Halliday, Renata S M Gomes, Rupesh Agrawal, Richard J Blanch
TOPIC: Sympathetic ophthalmia (SO) is a sight threatening granulomatous panuveitis caused by a sensitizing event. The use of primary enucleation or primary evisceration, versus primary repair, as a risk management strategy following OGI remains controversial. CLINICAL RELEVANCE: This systematic review was conducted to report the incidence of SO after primary repair compared to after primary enucleation or primary evisceration. This enabled the reporting of an estimated number needed to treat (NNT)...
December 10, 2023: Ophthalmology
#10
JOURNAL ARTICLE
Anke de Haan, Richard Meiser-Stedman, Markus A Landolt, Isla Kuhn, Melissa J Black, Kristel Klaus, Shivam D Patel, David J Fisher, Christina Haag, Obioha C Ukoumunne, Benjamin G Jones, Ashraf Muwafaq Flaiyah, Claudia Catani, Katie Dawson, Richard A Bryant, Carlijn de Roos, Verena Ertl, Edna B Foa, Julian D Ford, Eva Gilboa-Schechtman, Dunja Tutus, Katharin Hermenau, Tobias Hecker, Ole Hultmann, Ulf Axberg, Nasrin Jaberghaderi, Tine K Jensen, Silje M Ormhaug, Justin Kenardy, Ramon J L Lindauer, Julia Diehle, Laura K Murray, Jeremy C Kane, Kirsi Peltonen, Samuli Kangaslampi, Katy Robjant, Anke Koebach, Rita Rosner, Jaco Rossouw, Patrick Smith, Bruce J Tonge, Caitlin Hitchcock, Tim Dalgleish
BACKGROUND: Existing clinical trials of cognitive behavioural therapies with a trauma focus (CBTs-TF) are underpowered to examine key variables that might moderate treatment effects. We aimed to determine the efficacy of CBTs-TF for young people, relative to passive and active control conditions, and elucidate putative individual-level and treatment-level moderators. METHODS: This was an individual participant data meta-analysis of published and unpublished randomised studies in young people aged 6-18 years exposed to trauma...
January 2024: Lancet Child & Adolescent Health
#11
JOURNAL ARTICLE
Kibrom M Alula, Alexander S Dowdell, Brittany LeBere, J Scott Lee, Cassandra L Levens, Kristine A Kuhn, Benny A Kaipparettu, Winston E Thompson, Richard S Blumberg, Sean P Colgan, Arianne L Theiss
BACKGROUND: Intestinal epithelial cell (IEC) mitochondrial dysfunction involvement in inflammatory bowel diseases (IBD), including Crohn's disease affecting the small intestine, is emerging in recent studies. As the interface between the self and the gut microbiota, IECs serve as hubs of bidirectional cross-talk between host and luminal microbiota. However, the role of mitochondrial-microbiota interaction in the ileum is largely unexplored. Prohibitin 1 (PHB1), a chaperone protein of the inner mitochondrial membrane required for optimal electron transport chain function, is decreased during IBD...
November 17, 2023: Microbiome
#12
JOURNAL ARTICLE
Vitor Won-Held Rabelo, Verônica Diniz da Silva, Maria Leonisa Sanchez Nuñez, Leonardo Dos Santos Corrêa Amorim, Camilla Djenne Buarque, Richard J Kuhn, Paula Alvarez Abreu, Izabel Christina Nunes de Palmer Paixão
AIM: This work aimed to investigate the antiviral activity of two 1,4-disubstituted-1,2,3-triazole derivatives ( 1 and 2 ) against Chikungunya virus (CHIKV) replication. MATERIALS & METHODS: Cytotoxicity was analyzed using colorimetric assays and the antiviral potential was evaluated using plaque assays and computational tools. RESULTS: Compound 2 showed antiviral activity against CHIKV 181-25 in BHK-21 and Vero cells. Also, this compound presented a higher activity against CHIKV BRA/RJ/18 in Vero cells, like compound 1...
September 2023: Future Virology
#13
JOURNAL ARTICLE
Bárbara Antunes, Stephen Barclay, Isla Kuhn, Kathy Eagar, Claudia Bausewein, Fliss Murtagh, Simon Etkind, Ben Bowers, Sarah Dixon, Roberta Lovick, Richard Harding, Irene Higginson, Farhad Shokraneh
Background : Despite the development of patient-centred or patient-reported outcome measures (PCOMs or PROMs) in palliative and end-of-life care over recent years, their routine use in practice faces continuing challenges. Objective : To update a highly cited literature review, identify and synthesise new evidence on facilitators, barriers, lessons learned, PCOMs used, models of implementation, implementation outcomes, costs, and consequences of implementing PCOMs in palliative care clinical practice. Methods : We will search MEDLINE, PsycINFO, CINAHL, Embase, Emcare, SCI-Expanded, SSCI, ESCI, and BNI...
2023: F1000Research
#14
JOURNAL ARTICLE
Gina M Hilton, Yadvinder Bhuller, John E Doe, Douglas C Wolf, Richard A Currie
Regulatory science, rooted in legal requirements, provides a mechanism for identifying, assessing, and managing harm to humans and the environment from exposure to hazardous substances. A challenge for regulatory authorities is that many governing laws reflect the scientific paradigm of the mid-20th century. By the nature of legislative processes, most laws are not able to readily adapt to incorporate scientific advances that are inherent in an ever-evolving paradigm. Consequently, the issue of rigid legal frameworks has become prominent in global discussions related to the incorporation of reliable and relevant modern technology to fulfill regulatory needs...
November 2, 2023: Regulatory Toxicology and Pharmacology: RTP
#15
JOURNAL ARTICLE
Ruifeng Duan, Viktor H von Ehrlich-Treuenstätt, Sara C Kakoschke, Josefine Schardey, Ulrich Wirth, Markus Albertsmeier, Bernhard W Renz, Joachim Andrassy, Alexandr V Bazhin, Richard Hodin, Jens Werner, Matthias Ilmer, Florian Kühn
BACKGROUND: Intestinal homeostasis is a crucial factor for complication-free short- and long-term postoperative recovery. The brush border enzyme intestinal alkaline phosphatase (IAP) is an important regulator of gut barrier function, intestinal homeostasis, and prevents endotoxemia by detoxifying lipopolysaccharides (LPS). As IAP is predominantly secreted by enterocytes in the duodenum, we hypothesized that pancreaticoduodenectomy (PD) leads to a significant stronger decrease in IAP than other major abdominal surgery...
October 23, 2023: Journal of the American College of Surgeons
#16
REVIEW
Richard J Kuhn, Alan D T Barrett, Aravinda M Desilva, Eva Harris, Laura D Kramer, Ruth R Montgomery, Theodore C Pierson, Alessandro Sette, Michael S Diamond
Flaviviruses are a genus within the Flaviviridae family of positive-strand RNA viruses and are transmitted principally through mosquito and tick vectors. These viruses are responsible for hundreds of millions of human infections worldwide per year that result in a range of illnesses from self-limiting febrile syndromes to severe neurotropic and viscerotropic diseases and, in some cases, death. A vaccine against the prototype flavivirus, yellow fever virus, has been deployed for 85 years and is highly effective...
October 18, 2023: Journal of Infectious Diseases
#17
JOURNAL ARTICLE
Jason A Hackney, Haridha Shivram, Jason Vander Heiden, Chris Overall, Luz Orozco, Xia Gao, Eugene Kim, Nathan West, Aditi Qamra, Diana Chang, Arindam Chakrabarti, David F Choy, Alexis J Combes, Tristan Courau, Gabriela K Fragiadakis, Arjun Arkal Rao, Arja Ray, Jessica Tsui, Kenneth Hu, Nicholas F Kuhn, Matthew F Krummel, David J Erle, Kirsten Kangelaris, Aartik Sarma, Zoe Lyon, Carolyn S Calfee, Prescott G Woodruff, Rajani Ghale, Eran Mick, Ashley Byrne, Beth Shoshana Zha, Charles Langelier, Carolyn M Hendrickson, Monique G P van der Wijst, George C Hartoularos, Tianna Grant, Raymund Bueno, David S Lee, John R Greenland, Yang Sun, Richard Perez, Anton Ogorodnikov, Alyssa Ward, Chun Jimmie Ye, Thiru Ramalingam, Jacqueline M McBride, Fang Cai, Anastasia Teterina, Min Bao, Larry Tsai, Ivan O Rosas, Aviv Regev, Sharookh B Kapadia, Rebecca N Bauer, Carrie M Rosenberger
Altered myeloid inflammation and lymphopenia are hallmarks of severe infections. We identified the upregulated EN-RAGE gene program in airway and blood myeloid cells from patients with acute lung injury from SARS-CoV-2 or other causes across 7 cohorts. This program was associated with greater clinical severity and predicted future mechanical ventilation and death. EN-RAGEhi myeloid cells express features consistent with suppressor cell functionality, including low HLA-DR and high PD-L1. Sustained EN-RAGE program expression in airway and blood myeloid cells correlated with clinical severity and increasing expression of T cell dysfunction markers...
October 20, 2023: IScience
#18
Mickaël Avanthay, Belen Batanero, Christoph Bondue, Dylan G Boucher, Pim Broersen, Richard C D Brown, Luke Chen, Anthony Choi, Ching Wai Fong, Toshio Fuchigami, David P Hickey, Alexander Kuhn, Kevin Lam, Yun-Ju Liao, T Leo Liu, Shelley D Minteer, Kevin Moeller, Zachary A Nguyen, Naoki Shida
No abstract text is available yet for this article.
October 4, 2023: Faraday Discussions
#19
Timon Merk, Richard Köhler, Victoria Peterson, Laura Lyra, Jonathan Vanhoecke, Meera Chikermane, Thomas Binns, Ningfei Li, Ashley Walton, Alan Bush, Nathan Sisterson, Johannes Busch, Roxanne Lofredi, Jeroen Habets, Julius Huebl, Guanyu Zhu, Zixiao Yin, Baotian Zhao, Angela Merkl, Malek Bajbouj, Patricia Krause, Katharina Faust, Gerd-Helge Schneider, Andreas Horn, Jianguo Zhang, Andrea Kühn, R Mark Richardson, Wolf-Julian Neumann
Brain computer interfaces (BCI) provide unprecedented spatiotemporal precision that will enable significant expansion in how numerous brain disorders are treated. Decoding dynamic patient states from brain signals with machine learning is required to leverage this precision, but a standardized framework for identifying and advancing novel clinical BCI approaches does not exist. Here, we developed a platform that integrates brain signal decoding with connectomics and demonstrate its utility across 123 hours of invasively recorded brain data from 73 neurosurgical patients treated for movement disorders, depression and epilepsy...
September 20, 2023: Research Square
#20
REVIEW
Jessica Richards, Randall Kuhn
CONTEXT: In recent years, cities across the world have seen widespread growth in unsheltered homelessness, in which a person sleeps in a place not meant for human habitation such as cars, parks, sidewalks, and abandoned buildings. It is widely understood that people experiencing homelessness have poorer health outcomes than the general population. Less is known about the health of people who are unsheltered, yet they may be exposed to greater health risks than their sheltered counterparts...
March 2023: AJPM Focus
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