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Richard Kuhn

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https://www.readbyqxmd.com/read/28820272/a-comparison-of-clinical-outcomes-after-unilateral-or-bilateral-hip-arthroscopic-surgery-age-and-sex-matched-cohort-study
#1
Benjamin D Kuhns, Charles P Hannon, Eric C Makhni, Jennifer Alter, Richard C Mather, Michael J Salata, Shane J Nho
BACKGROUND: A significant number of patients undergoing hip arthroscopic surgery for femoroacetabular impingement (FAI) have bilateral deformities and may require surgery for both hips. PURPOSE: To compare outcomes between patients who underwent bilateral hip arthroscopic surgery to a matched cohort of patients who underwent unilateral hip arthroscopic surgery. STUDY DESIGN: Cohort study; Level of evidence, 3. METHODS: A consecutive series of patients who underwent primary hip arthroscopic surgery for FAI by a single fellowship-trained surgeon from January 2012 to January 2014 and had a minimum follow-up of 2 years were evaluated...
August 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28782633/plasma-cell-deficiency-in-humans-with-heterozygous-mutations-in-sec61a1
#2
Desirée Schubert, Marie-Christine Klein, Sarah Hassdenteufel, Andrés Caballero-Oteyza, Linlin Yang, Michele Proietti, Alla Bulashevska, Janine Kemming, Johannes Kühn, Sandra Winzer, Stephan Rusch, Manfred Fliegauf, Alejandro A Schäffer, Stefan Pfeffer, Roger Geiger, Adolfo Cavalié, Hongzhi Cao, Fang Yang, Yong Li, Marta Rizzi, Hermann Eibel, Robin Kobbe, Amy L Marks, Brian P Peppers, Robert W Hostoffer, Jennifer M Puck, Richard Zimmermann, Bodo Grimbacher
BACKGROUND: Primary antibody deficiencies (PAD) are the most frequent primary immunodeficiencies in humans. The genetic causes for PADs are largely unknown. Sec61 translocon alpha 1 subunit (SEC61A1) is the major subunit of the Sec61 complex, which is the main polypeptide-conducting channel in the endoplasmic reticulum (ER) membrane. SEC61A1 is a target gene of XBP1s and strongly induced during plasma cell differentiation. OBJECTIVE: Characterization of a novel genetic defect and its pathological mechanism in eleven patients from two unrelated families with PAD...
August 3, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28758831/tet1-deficiency-attenuates-the-dna-damage-response-and-promotes-resistance-to-dna-damaging-agents
#3
Jonathan B Coulter, Hernando Lopez-Bertoni, Katherine J Kuhns, Richard S Lee, John Laterra, Joseph P Bressler
Recent studies have shown that loss of TET1 may play a significant role in the formation of tumors. Because genomic instability is a hallmark of cancer, we examined the potential involvement of ten-eleven translocation 1 (TET1) in the DNA damage response (DDR). Here we demonstrate that, in response to clinically relevant doses of ionizing radiation (IR), human glial cells made TET1-deficient with lentiviral vectors displayed greater numbers of colony forming units and lower levels of apoptotic markers compared to glial cells transduced with control vectors; yet, they harbored greater DNA strand breaks...
July 31, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/28743434/editorial-overview-virus-structure-and-functions
#4
EDITORIAL
Theodore Jardetzky, Richard Kuhn, Robert Lamb
No abstract text is available yet for this article.
June 2017: Current Opinion in Virology
https://www.readbyqxmd.com/read/28732055/role-of-htra1-in-bone-formation-and-regeneration-in-vitro-and-in-vivo-evaluation
#5
Gladys Filliat, Ali Mirsaidi, André N Tiaden, Gisela A Kuhn, Franz E Weber, Chio Oka, Peter J Richards
The role of mammalian high temperature requirement protease A1 (HTRA1) in somatic stem cell differentiation and mineralized matrix formation remains controversial, having been demonstrated to impart either anti- or pro-osteogenic effects, depending on the in vitro cell model used. The aim of this study was therefore to further evaluate the role of HTRA1 in regulating the differentiation potential and lineage commitment of murine mesenchymal stem cells in vitro, and to assess its influence on bone structure and regeneration in vivo...
2017: PloS One
https://www.readbyqxmd.com/read/28678784/personalized-rna-mutanome-vaccines-mobilize-poly-specific-therapeutic-immunity-against-cancer
#6
Ugur Sahin, Evelyna Derhovanessian, Matthias Miller, Björn-Philipp Kloke, Petra Simon, Martin Löwer, Valesca Bukur, Arbel D Tadmor, Ulrich Luxemburger, Barbara Schrörs, Tana Omokoko, Mathias Vormehr, Christian Albrecht, Anna Paruzynski, Andreas N Kuhn, Janina Buck, Sandra Heesch, Katharina H Schreeb, Felicitas Müller, Inga Ortseifer, Isabel Vogler, Eva Godehardt, Sebastian Attig, Richard Rae, Andrea Breitkreuz, Claudia Tolliver, Martin Suchan, Goran Martic, Alexander Hohberger, Patrick Sorn, Jan Diekmann, Janko Ciesla, Olga Waksmann, Alexandra-Kemmer Brück, Meike Witt, Martina Zillgen, Andree Rothermel, Barbara Kasemann, David Langer, Stefanie Bolte, Mustafa Diken, Sebastian Kreiter, Romina Nemecek, Christoffer Gebhardt, Stephan Grabbe, Christoph Höller, Jochen Utikal, Christoph Huber, Carmen Loquai, Özlem Türeci
T cells directed against mutant neo-epitopes drive cancer immunity. However, spontaneous immune recognition of mutations is inefficient. We recently introduced the concept of individualized mutanome vaccines and implemented an RNA-based poly-neo-epitope approach to mobilize immunity against a spectrum of cancer mutations. Here we report the first-in-human application of this concept in melanoma. We set up a process comprising comprehensive identification of individual mutations, computational prediction of neo-epitopes, and design and manufacturing of a vaccine unique for each patient...
July 13, 2017: Nature
https://www.readbyqxmd.com/read/28655823/can-an-fda-approved-alzheimer-s-drug-be-repurposed-for-alleviating-neuronal-symptoms-of-zika-virus
#7
Devika Sirohi, Richard J Kuhn
Zika virus caught the world by surprise by its rapid spread and frightening disease outcomes. This major epidemic motivated many scientists to focus their attention on controlling this emerging pathogen. As many as 45 vaccine candidates are being developed, but progress in the antiviral arena has been slower. In a recent article (mBio 8:e00350-17, 2017, https://doi.org/10.1128/mBio.00350-17), Costa and colleagues showed that an FDA-approved drug used to treat Alzheimer's disease may moderate Zika virus-induced neuronal damage...
June 27, 2017: MBio
https://www.readbyqxmd.com/read/28582774/a-giant-planet-undergoing-extreme-ultraviolet-irradiation-by-its-hot-massive-star-host
#8
B Scott Gaudi, Keivan G Stassun, Karen A Collins, Thomas G Beatty, George Zhou, David W Latham, Allyson Bieryla, Jason D Eastman, Robert J Siverd, Justin R Crepp, Erica J Gonzales, Daniel J Stevens, Lars A Buchhave, Joshua Pepper, Marshall C Johnson, Knicole D Colon, Eric L N Jensen, Joseph E Rodriguez, Valerio Bozza, Sebastiano Calchi Novati, Giuseppe D'Ago, Mary T Dumont, Tyler Ellis, Clement Gaillard, Hannah Jang-Condell, David H Kasper, Akihiko Fukui, Joao Gregorio, Ayaka Ito, John F Kielkopf, Mark Manner, Kyle Matt, Norio Narita, Thomas E Oberst, Phillip A Reed, Gaetano Scarpetta, Denice C Stephens, Rex R Yeigh, Roberto Zambelli, B J Fulton, Andrew W Howard, David J James, Matthew Penny, Daniel Bayliss, Ivan A Curtis, D L DePoy, Gilbert A Esquerdo, Andrew Gould, Michael D Joner, Rudolf B Kuhn, Jonathan Labadie-Bartz, Michael B Lund, Jennifer L Marshall, Kim K McLeod, Richard W Pogge, Howard Relles, Christopher Stockdale, T G Tan, Mark Trueblood, Patricia Trueblood
The amount of ultraviolet irradiation and ablation experienced by a planet depends strongly on the temperature of its host star. Of the thousands of extrasolar planets now known, only six have been found that transit hot, A-type stars (with temperatures of 7,300-10,000 kelvin), and no planets are known to transit the even hotter B-type stars. For example, WASP-33 is an A-type star with a temperature of about 7,430 kelvin, which hosts the hottest known transiting planet, WASP-33b (ref. 1); the planet is itself as hot as a red dwarf star of type M (ref...
June 22, 2017: Nature
https://www.readbyqxmd.com/read/28532404/use-of-the-qiagen-genereader-ngs-system-for-detection-of-kras-mutations-validated-by-the-qiagen-therascreen-pcr-kit-and-alternative-ngs-platform
#9
Agus Darwanto, Anne-Mette Hein, Sascha Strauss, Yi Kong, Andrew Sheridan, Dan Richards, Eric Lader, Monika Ngowe, Timothy Pelletier, Danielle Adams, Austin Ricker, Nishit Patel, Andreas Kühne, Simon Hughes, Dan Shiffman, Dirk Zimmermann, Kai Te Kaat, Thomas Rothmann
BACKGROUND: The detection of somatic mutations in primary tumors is critical for the understanding of cancer evolution and targeting therapy. Multiple technologies have been developed to enable the detection of such mutations. Next generation sequencing (NGS) is a new platform that is gradually becoming the technology of choice for genotyping cancer samples, owing to its ability to simultaneously interrogate many genomic loci at massively high efficiency and increasingly lower cost. However, multiple barriers still exist for its broader adoption in clinical research practice, such as fragmented workflow and complex bioinformatics analysis and interpretation...
May 22, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28520460/the-influence-of-body-mass-index-on-outcomes-after-hip-arthroscopic-surgery-with-capsular-plication-for-the-treatment-of-femoroacetabular-impingement
#10
Bryan M Saltzman, Benjamin D Kuhns, Bryce Basques, Timothy Leroux, Jennifer Alter, Richard C Mather, Michael J Salata, Shane J Nho
BACKGROUND: It remains unknown how variations in body mass index (BMI) influence outcomes after primary hip arthroscopic surgery with capsular plication for femoroacetabular impingement (FAI). PURPOSE: To evaluate the effect that abnormal BMI (namely, overweight, obese, morbidly obese, and underweight) versus normal weight has on patient-reported clinical outcomes more than 2 years postoperatively from primary hip arthroscopic surgery with capsular plication by a single surgeon...
August 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28441511/do-patients-with-borderline-dysplasia-have-inferior-outcomes-after-hip-arthroscopic-surgery-for-femoroacetabular-impingement-compared-with-patients-with-normal-acetabular-coverage
#11
Gregory L Cvetanovich, David M Levy, Alexander E Weber, Benjamin D Kuhns, Richard C Mather, Michael J Salata, Shane J Nho
BACKGROUND: The literature contains conflicting reports regarding whether outcomes of hip arthroscopic surgery for patients with borderline dysplasia are inferior to outcomes in patients with normal acetabular coverage. PURPOSE: To assess differences in the outcomes of hip arthroscopic surgery for femoroacetabular impingement (FAI) in groups of patients with borderline dysplasia and normal coverage. STUDY DESIGN: Cohort study; Level of evidence, 3...
April 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28380995/wavelength-calibration-of-a-high-resolution-spectrograph-with-a-partially-stabilized-15-ghz-astrocomb-from-550-to-890-nm
#12
Richard A McCracken, Éric Depagne, Rudolf B Kuhn, Nicolas Erasmus, Lisa A Crause, Derryck T Reid
A visible astrocomb spanning 555-890 nm has been implemented on the 10-m Southern African Large Telescope, delivering complete calibration of one channel of its high-resolution spectrograph and an accurate determination of its resolving power. A novel co-coupling method allowed simultaneous observation of on-sky, Th-Ar lamp and astrocomb channels, reducing the wavelength calibration uncertainty by a factor of two compared to that obtained using only Th-Ar lines. The excellent passive stability of the master frequency comb laser enabled broadband astrocomb generation without the need for carrier-envelope offset frequency locking, and an atomically referenced narrow linewidth diode laser provided an absolute fiducial marker for wavelength calibration...
March 20, 2017: Optics Express
https://www.readbyqxmd.com/read/28300075/a-human-antibody-against-zika-virus-crosslinks-the-e-protein-to-prevent-infection
#13
S Saif Hasan, Andrew Miller, Gopal Sapparapu, Estefania Fernandez, Thomas Klose, Feng Long, Andrei Fokine, Jason C Porta, Wen Jiang, Michael S Diamond, James E Crowe, Richard J Kuhn, Michael G Rossmann
The recent Zika virus (ZIKV) epidemic has been linked to unusual and severe clinical manifestations including microcephaly in fetuses of infected pregnant women and Guillian-Barré syndrome in adults. Neutralizing antibodies present a possible therapeutic approach to prevent and control ZIKV infection. Here we present a 6.2 Å resolution three-dimensional cryo-electron microscopy (cryoEM) structure of an infectious ZIKV (strain H/PF/2013, French Polynesia) in complex with the Fab fragment of a highly therapeutic and neutralizing human monoclonal antibody, ZIKV-117...
March 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/28196962/spatial-and-temporal-analysis-of-alphavirus-replication-and-assembly-in-mammalian-and-mosquito-cells
#14
Joyce Jose, Aaron B Taylor, Richard J Kuhn
Sindbis virus (SINV [genus Alphavirus, family Togaviridae]) is an enveloped, mosquito-borne virus. Alphaviruses cause cytolytic infections in mammalian cells while establishing noncytopathic, persistent infections in mosquito cells. Mosquito vector adaptation of alphaviruses is a major factor in the transmission of epidemic strains of alphaviruses. Though extensive studies have been performed on infected mammalian cells, the morphological and structural elements of alphavirus replication and assembly remain poorly understood in mosquito cells...
February 14, 2017: MBio
https://www.readbyqxmd.com/read/28134265/consensus-statement-virus-taxonomy-in-the-age-of-metagenomics
#15
Peter Simmonds, Mike J Adams, Mária Benkő, Mya Breitbart, J Rodney Brister, Eric B Carstens, Andrew J Davison, Eric Delwart, Alexander E Gorbalenya, Balázs Harrach, Roger Hull, Andrew M Q King, Eugene V Koonin, Mart Krupovic, Jens H Kuhn, Elliot J Lefkowitz, Max L Nibert, Richard Orton, Marilyn J Roossinck, Sead Sabanadzovic, Matthew B Sullivan, Curtis A Suttle, Robert B Tesh, René A van der Vlugt, Arvind Varsani, F Murilo Zerbini
The number and diversity of viral sequences that are identified in metagenomic data far exceeds that of experimentally characterized virus isolates. In a recent workshop, a panel of experts discussed the proposal that, with appropriate quality control, viruses that are known only from metagenomic data can, and should be, incorporated into the official classification scheme of the International Committee on Taxonomy of Viruses (ICTV). Although a taxonomy that is based on metagenomic sequence data alone represents a substantial departure from the traditional reliance on phenotypic properties, the development of a robust framework for sequence-based virus taxonomy is indispensable for the comprehensive characterization of the global virome...
March 2017: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/28133442/measuring-and-specifying-combinatorial-coverage-of-test-input-configurations
#16
D Richard Kuhn, Raghu N Kacker, Yu Lei
A key issue in testing is how many tests are needed for a required level of coverage or fault detection. Estimates are often based on error rates in initial testing, or on code coverage. For example, tests may be run until a desired level of statement or branch coverage is achieved. Combinatorial methods present an opportunity for a different approach to estimating required test set size, using characteristics of the test set. This paper describes methods for estimating the coverage of, and ability to detect, t-way interaction faults of a test set based on a covering array...
December 2016: Innovations in Systems and Software Engineering
https://www.readbyqxmd.com/read/28107887/associations-between-positive-emotional-well-being-and-stress-induced-myocardial-ischemia-well-being-scores-predict-exercise-induced-ischemia
#17
Jacob P Feigal, Stephen H Boyle, Zainab Samad, Eric J Velazquez, Jennifer L Wilson, Richard C Becker, Redford B Williams, Cynthia M Kuhn, Thomas L Ortel, Joseph G Rogers, Christopher M O'Connor, Wei Jiang
OBJECTIVE: Depressive symptoms have been associated with myocardial ischemia induced by mental (MSIMI) and exercise (ESIMI) stress in clinically stable ischemic heart disease (IHD) patients, but the association between positive emotions and inducible ischemia is less well characterized. The objective of this study was to examine the associations between ratings of well-being and stress-induced ischemia. METHODS: Subjects were adult patients with documented IHD underwent mental and exercise stress testing for the Responses of Myocardial Ischemia to Escitalopram Treatment (REMIT) trial...
February 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28086865/rnai-reveals-proteins-for-metabolism-and-protein-processing-associated-with-langat-virus-infection-in-ixodes-scapularis-black-legged-tick-ise6-cells
#18
Jeffrey M Grabowski, Monika Gulia-Nuss, Richard J Kuhn, Catherine A Hill
BACKGROUND: Tick-borne flaviviruses (TBFs) cause thousands of human cases of encephalitis worldwide each year, with some TBF infections progressing to hemorrhagic fever. TBFs are of medical and veterinary importance and strategies to reduce flavivirus transmission by the tick vector may have significant application. Analyses of the proteome of ISE6 cells derived from the black legged tick, Ixodes scapularis infected with the TBF, Langat virus (LGTV), have provided insights into proteins and cellular processes involved with LGTV infection...
January 13, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28078475/50-years-of-the-international-committee-on-taxonomy-of-viruses-progress-and-prospects
#19
Michael J Adams, Elliot J Lefkowitz, Andrew M Q King, Balázs Harrach, Robert L Harrison, Nick J Knowles, Andrew M Kropinski, Mart Krupovic, Jens H Kuhn, Arcady R Mushegian, Max L Nibert, Sead Sabanadzovic, Hélène Sanfaçon, Stuart G Siddell, Peter Simmonds, Arvind Varsani, Francisco Murilo Zerbini, Richard J Orton, Donald B Smith, Alexander E Gorbalenya, Andrew J Davison
We mark the 50th anniversary of the International Committee on Taxonomy of Viruses (ICTV) by presenting a brief history of the organization since its foundation, showing how it has adapted to advancements in our knowledge of virus diversity and the methods used to characterize it. We also outline recent developments, supported by a grant from the Wellcome Trust (UK), that are facilitating substantial changes in the operations of the ICTV and promoting dialogue with the virology community. These developments will generate improved online resources, including a freely available and regularly updated ICTV Virus Taxonomy Report...
May 2017: Archives of Virology
https://www.readbyqxmd.com/read/28078102/repeated-mild-traumatic-brain-injury-causes-focal-response-in-lateral-septum-and-hippocampus
#20
Rebecca Acabchuk, Denise I Briggs, Mariana Angoa-Pérez, Meghan Powers, Richard Wolferz, Melanie Soloway, Mai Stern, Lillian R Talbot, Donald M Kuhn, Joanne C Conover
AIM: To advance our understanding of regional and temporal cellular responses to repeated mild traumatic brain injury (rmTBI), we used a mouse model of rmTBI that incorporated acceleration, deceleration and rotational forces. MATERIALS & METHODS: A modified weight-drop method was used to compare two inter-injury intervals, rmTBI-short (five hits delivered over 3 days) and rmTBI-long (five hits delivered over 15 days). Regional investigations of forebrain and midbrain histological alterations were performed at three post-injury time points (immediate, 2 weeks and 6 weeks)...
December 2016: Concussion
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