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https://www.readbyqxmd.com/read/29775994/a-broader-understanding-of-care-managers-attitudes-of-advance-care-planning-a-concurrent-nested-design
#1
Julie Aultman, Kristin R Baughman, Ruth Ludwick
AIMS AND OBJECTIVES: To examine barriers of advance care planning (ACP) experienced by care managers (CMs) through a mixed methods approach. A concurrent nested design was used to acquire a deeper understanding of ACP, and to identify nuances between quantitative and qualitative data. BACKGROUND: Past quantitative studies on providers have identified barriers related to time, culture, knowledge, responsibility, and availability of legal documents. These barriers, and accompanying attitudes and feelings, have been taken at face value without rich qualitative data to identify under what conditions and to what extent a barrier impacts care...
May 18, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29775509/exploring-the-growth-trajectory-of-cultural-competence-in-taiwanese-paediatric-nurses
#2
Chiu-I Chen, Mei-Chih Huang
AIM: The purpose of this study was to explore the evolution of cultural competence in Taiwanese paediatric nurses. BACKGROUND: Because transnational marriage has become a social phenomenon in Taiwan, the proportion of newborns of new immigrant mothers accounts for 8-10% of total births every year. Since family-centered care is the core value of paediatric nursing, it is necessary to teach caregivers how to take care of hospitalized children and perform related nursing care as well as to determine what difficulties nurses will encounter when they care for patients from diverse cultures and to find solutions for these problems...
May 18, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29769451/effect-of-ferulic-acid-supplementation-on-the-developmental-competence-of-porcine-embryos-during-in-vitro-maturation
#3
Fuminori Tanihara, Maki Hirata, Nguyen Thi Nhien, Takayuki Hirano, Toshiki Kunihara, Takeshige Otoi
The value of laboratory and genetically-modified pigs is becoming increasingly clear; however, their in vitro development remains inefficient. Trans-ferulic acid (trans-FA) is an aromatic compound that is abundant in plant cell walls, and which exhibits antioxidant effects in vitro. Trans-FA is known to improve sperm viability and motility; however, its effects on porcine oocytes are unknown. Our aim was to investigate the effects of trans-FA supplementation during in vitro maturation on the meiotic and developmental competence of porcine oocytes...
May 16, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29769080/a-complex-culturally-targeted-intervention-to-reduce-hispanic-disparities-in-living-kidney-donor-transplantation-an-effectiveness-implementation-hybrid-study-protocol
#4
Elisa J Gordon, Jungwha Lee, Raymond H Kang, Juan Carlos Caicedo, Jane L Holl, Daniela P Ladner, Michelle D Shumate
BACKGROUND: The shortage of organs for kidney transplantation for patients with end-stage renal disease (ESRD) is magnified in Hispanics/Latin Americans in the United States. Living donor kidney transplantation (LDKT) is the treatment of choice for ESRD. However, compared to their representation on the transplant waitlist, fewer Hispanics receive a LDKT than non-Hispanic whites. Barriers to LDKT for Hispanics include: lack of knowledge, cultural concerns, and language barriers. Few interventions have been designed to reduce LDKT disparities...
May 16, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29762797/contrasting-incoming-medical-students-attitudes-dual-degree-vs-traditional-tracks
#5
Kristina A Monteiro, Karl Dietrich, Jeffrey Borkan, Luba Dumenco, Allan R Tunkel, Richard Dollase, Paul George
BACKGROUND AND OBJECTIVES: The Warren Alpert Medical School of Brown University (AMS) recently implemented a novel dual degree MD-ScM program in primary care and population medicine (PC-PM) that enrolls up to 24 of its nearly 144 yearly matriculants. The overarching goal of this track is to train medical students to become physician leaders who focus on issues in population medicine within primary care. METHODS: We conducted a baseline assessment of the students enrolled in this parallel track in comparison to our traditional students to identify characteristics of and group differences between students in the PC-PM program and traditional students...
May 2018: Family Medicine
https://www.readbyqxmd.com/read/29762795/addressing-racism-in-medical-education-an-interactive-training-module
#6
Tanya White-Davis, Jennifer Edgoose, Joedrecka S Brown Speights, Kathryn Fraser, Jeffrey M Ring, Jessica Guh, George W Saba
BACKGROUND AND OBJECTIVES: Education of health care clinicians on racial and ethnic disparities has primarily focused on emphasizing statistics and cultural competency, with minimal attention to racism. Learning about racism and unconscious processes provides skills that reduce bias when interacting with minority patients. This paper describes the responses to a relationship-based workshop and toolkit highlighting issues that medical educators should address when teaching about racism in the context of pernicious health disparities...
May 2018: Family Medicine
https://www.readbyqxmd.com/read/29762687/glycine-treatment-enhances-developmental-potential-of-porcine-oocytes-and-early-embryos-by-inhibiting-apoptosis
#7
Suo Li, Qing Guo, Yu-Meng Wang, Zi-Yue Li, Jin-Dan Kang, Xi-Jun Yin, Xin Zheng
Glycine, a component of glutathione (GSH), plays an important role in protection from reactive oxygen species (ROS) and inhibition of apoptosis. The aim of this study was to determine the effect of glycine on in vitro maturation (IVM) of porcine oocytes and their developmental competence after parthenogenetic activation (PA). We examined nuclear maturation, ROS levels, apoptosis, mitochondrial membrane potential (ΔΨm), and ATP concentration, as well as the expression of several genes related to oocyte maturation and development...
May 12, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29760902/exploring-the-evolution-of-multicellularity-in-saccharomyces-cerevisiae-under-bacteria-environment-an-experimental-phylogenetics-approach
#8
Julian F Quintero-Galvis, Rocío Paleo-López, Jaiber J Solano-Iguaran, María Josefina Poupin, Thomas Ledger, Juan Diego Gaitan-Espitia, Andrzej Antoł, Michael Travisano, Roberto F Nespolo
There have been over 25 independent unicellular to multicellular evolutionary transitions, which have been transformational in the complexity of life. All of these transitions likely occurred in communities numerically dominated by unicellular organisms, mostly bacteria. Hence, it is reasonable to expect that bacteria were involved in generating the ecological conditions that promoted the stability and proliferation of the first multicellular forms as protective units. In this study, we addressed this problem by analyzing the occurrence of multicellularity in an experimental phylogeny of yeasts ( Sacharomyces cerevisiae ) a model organism that is unicellular but can generate multicellular clusters under some conditions...
May 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29760771/systematic-review-cultural-adaptation-and-feasibility-of-screening-for-autism-in-non-english-speaking-countries
#9
REVIEW
Turkiya S Al Maskari, Craig A Melville, Diane S Willis
Background: Screening children for autism has gained wider acceptance within clinical practice, and early intervention has improved outcomes. Increasingly, adapting an existing screening instrument is a common, fast method to create a usable screening tool, especially for countries with limited resources and/or expertise. However, concerns have been raised regarding adaptation adequacy and the feasibility of screening across cultural groups. This study systematically examined the levels of cultural adaptation and feasibility aspects considered when screening for autism in non-English speaking countries to build upon the sparse knowledge that exists on this topic in the literature...
2018: International Journal of Mental Health Systems
https://www.readbyqxmd.com/read/29759892/the-marginalisation-of-dreams-in-clinical-psychological-practice
#10
REVIEW
Linda Leonard, Drew Dawson
The longstanding human interest in dreams has led to a significant body of psychological and philosophical discourse, including research. Recently, however, dreams have been relegated to the periphery of clinical psychological practice. This is potentially problematic as clients continue to bring dreams to therapy and many psychologists lack the confidence or competence to respond effectively to dream material. Building on the structural, professional and research cultures surrounding psychology using a cultural-historical activity theory framework, we argue the marginalisation of dreams is due to cultural-historical factors...
April 22, 2018: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/29756791/individual-and-group-cognitive-processing-therapy-effectiveness-across-two-veterans-affairs-posttraumatic-stress-disorder-treatment-clinics
#11
Kristen E Lamp, Kimberly M Avallone, Kelly P Maieritsch, Katherine R Buchholz, Sheila A M Rauch
OBJECTIVE: In accordance with Veterans Affairs (VA) policy, VA posttraumatic stress disorder (PTSD) clinics offer evidence-based treatments including cognitive processing therapy (CPT). To facilitate access to care, CPT is offered in both group and individual formats in many VA PTSD clinics. Group and individual delivery of CPT have been directly compared in active duty samples, but these findings have not been extended to VA populations. The present article directly compares the effectiveness of group and individual CPT with a written trauma account (CPT+A) across two VA PTSD clinics...
May 14, 2018: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/29756044/gender-dysphoria-in-adults-an-overview-and-primer-for-psychiatrists
#12
William Byne, Dan H Karasic, Eli Coleman, A Evan Eyler, Jeremy D Kidd, Heino F L Meyer-Bahlburg, Richard R Pleak, Jack Pula
Regardless of their area of specialization, adult psychiatrists are likely to encounter gender-variant patients; however, medical school curricula and psychiatric residency training programs devote little attention to their care. This article aims to assist adult psychiatrists who are not gender specialists in the delivery of respectful, clinically competent, and culturally attuned care to gender-variant patients, including those who identify as transgender or transsexual or meet criteria for the diagnosis of Gender Dysphoria (GD) as defined by The Diagnostic and Statistical Manual of Mental Disorders (5th edition)...
2018: Transgender Health
https://www.readbyqxmd.com/read/29755213/stereotype-content-warmth-and-competence-endure
#13
Susan T Fiske
Two dimensions persist in social cognition, whether people are making sense of individuals or groups. The Stereotype Content Model terms the basic dimensions perceived warmth (trustworthiness, friendliness) and competence (capability, assertiveness). Measured reliably and validly, these Big Two dimensions converge across methods: survey, cultural, laboratory, and biobehavioral approaches. Generality across place, levels, and time further support the framework. Parallel pairs have emerged repeatedly over the history of psychology and in current theories...
April 2018: Current Directions in Psychological Science
https://www.readbyqxmd.com/read/29752296/melatonin-attenuates-postovulatory-oocyte-dysfunction-by-regulating-sirt1-expression
#14
Qingling Yang, Shanjun Dai, Xiaoyan Luo, Jing Zhu, Fangyuan Li, Jinhao Liu, Guidong Yao, Yingpu Sun
The quality of postovulatory metaphase II oocytes undergoes a time-dependent deterioration as a result of the aging process. Melatonin is considered an anti-aging agent. However, the underlying mechanisms of how melatonin improves the quality of postovulatory aged oocytes remain largely unclear. In this study, by using mouse model, we found that there were elevated ROS levels and impaired mitochondrial function demonstrated by reduced mitochondrial membrane potential (ΔΨm) and increased mitochondrial aggregation in oocytes aged 24 h, accompanied by an increased number of meiotic errors, unregulated autophagy-related proteins and early apoptosis, which led to decreased oocyte quality and disrupted developmental competence...
May 11, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29751973/advancing-indigenous-primary-health-care-policy-in-alberta-canada
#15
Rita Henderson, Stephanie Montesanti, Lindsay Crowshoe, Charles Leduc
For Indigenous people worldwide, accessing Primary Health Care (PHC) services responsive to socio-cultural realities is challenging, with institutional inequities in healthcare and jurisdictional barriers encumbering patients, providers, and decision-makers. In the Canadian province of Alberta, appropriate Indigenous health promotion, disease prevention, and primary care health services are needed, though policy reform is hindered by complex networks and competing interests between: federal/provincial funders; reserve/urban contexts; medical/allied health professional priorities; and three Treaty territories each structuring fiduciary responsibilities of the Canadian government...
May 7, 2018: Health Policy
https://www.readbyqxmd.com/read/29750899/bmp-2-enhances-the-migration-and-proliferation-of-hypoxia-induced-vsmcs-via-actin-cytoskeleton-cd44-and-matrix-metalloproteinase-linkage
#16
Min Yang, Zhiqin Fan, Fei Wang, Zhi-Hua Tian, Bo Ma, Bing Dong, Zhongwu Li, Ming Zhang, Wei Zhao
The persistent proliferation of hypoxia-induced vascular smooth muscle cells (VSMCs) in the arterial wall underlie the development of atherosclerosis. However, the mechanism that regulates the behavior of VSMCs, which involve in actin aggregation, and impedes their migration is still elusive. Here, we report that bone morphogenetic protein 2 (BMP-2) leads to enrichment of CD44 and F-actin stress fiber and secretion of matrix metalloproteinases-2 (MMP-2) during hypoxia in vitro and following artificial hypoxia-induced atherosclerosis exacerbation in vivo...
May 8, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29743375/expression-levels-of-glycoprotein-o-go-vary-between-strains-of-human-cytomegalovirus-influencing-the-assembly-of-gh-gl-complexes-and-virion-infectivity
#17
Le Zhang, Momei Zhou, Richard Stanton, Jeremy Kamil, Brent J Ryckman
Tropism of human cytomegalovirus (HCMV) is influenced by the envelope glycoprotein complexes gH/gL/gO and gH/gL/UL128-131. During virion assembly, gO and the UL128-131 proteins compete for binding to gH/gL in the ER. This assembly process clearly differs among strains since Merlin (ME) virions contain abundant gH/gL/UL128-131 and little gH/gL/gO, whereas TR contains much higher levels of total gH/gL, mostly in the form of gH/gL/gO, but much less gH/gL/UL128-131 than ME. Remaining questions include 1) what are the mechanisms behind these assembly differences, and 2) do differences reflect in vitro culture adaptations or natural genetic variations? Since the UL74(gO) ORF differs by 25% of amino acids between TR and ME, we analyzed recombinant viruses in which the UL74(gO) ORF was swapped...
May 9, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29742510/hmgb1-a-box-reverses-brain-edema-and-deterioration-of-neurological-function-in-a-traumatic-brain-injury-mouse-model
#18
Lijun Yang, Feng Wang, Liang Yang, Yunchao Yuan, Yan Chen, Gengshen Zhang, Zhenzeng Fan
BACKGROUND/AIMS: Traumatic brain injury (TBI) is a complex neurological injury in young adults lacking effective treatment. Emerging evidences suggest that inflammation contributes to the secondary brain injury following TBI, including breakdown of the blood brain barrier (BBB), subsequent edema and neurological deterioration. High mobility group box-1 (HMGB1) has been identified as a key cytokine in the inflammation reaction following TBI. Here, we investigated the therapeutic efficacy of HMGB1 A-box fragment, an antagonist competing with full-length HMGB1 for receptor binding, against TBI...
May 8, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29740747/mothers-in-same-sex-relationships-describe-the-process-of-forming-a-family-as-a-stressful-journey-in-a-heteronormative-world-a-swedish-grounded-theory-study
#19
Heléne Appelgren Engström, Elisabet Häggström-Nordin, Catrin Borneskog, Anna-Lena Almqvist
Objectives The aim of this study was to gain insight into how women in same-sex relationships experience the process of forming a family through the use of assisted reproduction technique (ART), from planning the pregnancy to parenthood, and their experience of parental support from healthcare professionals. Methods The participants were 20 women in a same-sex relationship who had conceived through ART at a Swedish clinic. Semi-structured interviews including open questions about pregnancy, parenthood and support from healthcare professionals were conducted...
May 8, 2018: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29738944/sex-differences-in-traumatic-events-and-psychiatric-morbidity-associated-to-probable-posttraumatic-stress-disorder-among-latino-prisoners
#20
Coralee Pérez-Pedrogo, Alfonso Martínez-Taboas, Rafael A González, José N Caraballo, Carmen E Albizu-García
Latinos comprised 17.1% of the U.S. population and 33.1% of US prisoners, yet they are underrepresented in the psychopathology literature. Despite higher rates of trauma among incarcerated individuals than in the general population, most of the previous research in this area focused primarily on women samples, and very few studies examined sex differences in PTSD and traumatic experiences. In addition, there is a need for research assessing traumatic experiences and probable PTSD in men and women Latino inmates to inform culturally competent care and sex sensitive care for this vulnerable and underserved population...
April 14, 2018: Psychiatry Research
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