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https://www.readbyqxmd.com/read/28067298/widespread-temporo-occipital-lobe-dysfunction-in-amyotrophic-lateral-sclerosis
#1
Kristian Loewe, Judith Machts, Jörn Kaufmann, Susanne Petri, Hans-Jochen Heinze, Christian Borgelt, Joseph Allen Harris, Stefan Vielhaber, Mircea Ariel Schoenfeld
Recent studies suggest that amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) lie on a single clinical continuum. However, previous neuroimaging studies have found only limited involvement of temporal lobe regions in ALS. To better delineate possible temporal lobe involvement in ALS, the present study aimed to examine changes in functional connectivity across the whole brain, particularly with regard to extra-motor regions, in a group of 64 non-demented ALS patients and 38 healthy controls...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28059501/a-high-quantum-yield-mitochondria-targeting-near-infrared-fluorescent-probe-for-imaging-native-hypobromous-acid-in-living-cells-and-in-vivo
#2
Xiaojun Liu, Aishan Zheng, Dongrui Luan, Xiaoting Wang, Fanpeng Kong, Lili Tong, Kehua Xu, Bo Tang
The discovery that hypobromous acid (HOBr) can regulate the activity of collagen IV has attracted great attention. However, HOBr as an important reactive small molecule has hardly ever been studied using a detection method suitable for organisms. Herein, a high-quantum-yield mitochondria-targeting near-infrared (NIR) fluorescent probe for HOBr, RhSN-mito, was designed. RhSN-mito was easily obtained by the Suzuki cross-coupling reaction. The test results show that RhSN-mito can rapidly respond to HOBr with ultrasensitivity and high selectivity...
January 5, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28050657/median-arcuate-ligament-syndrome-a-single-center-experience-with-23-patients
#3
Layla A Nasr, Walid G Faraj, Aghiad Al-Kutoubi, Mohamad Hamady, Mohamad Khalifeh, Ali Hallal, Hamzeh M Halawani, Joelle Wazen, Ali A Haydar
BACKGROUND: Median arcuate ligament syndrome (MALS) is a rare entity that occurs when the median arcuate ligament of the diaphragm is low-lying, causing a compression to the underlying celiac trunk. We reviewed the vascular changes associated with MALS in an effort to emphasize the seriousness of this disease and the complications that may result. METHODS: This is a retrospective descriptive analysis of 23 consecutive patients diagnosed with MALS between January 1, 2012 and December 31, 2015 at a tertiary medical center...
January 3, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28045304/the-current-state-and-future-of-factor-analysis-in-personality-disorder-research
#4
Aidan G C Wright
The major debates in the personality disorder (PD) field center on the structure of personality pathology. Factor analysis is designed to elucidate the underlying structure of observed phenomena. Therefore, factor analysis has already played a major role in the debates about the structure of PD, and will continue to be an often-used and indispensable tool moving forward. However, misconceptions about the utility and interpretation of factor analyses abound. The purpose of this article is to provide a conceptual primer on available factor analytic techniques and how they have been applied in PD research, and to highlight novel ways of using factor analysis moving forward...
January 2017: Personality Disorders
https://www.readbyqxmd.com/read/28042729/critical-laboratory-values-in-hemostasis-towards-consensus
#5
Giuseppe Lippi, Dorothy Adcock, Ana-Maria Simundic, Armando Tripodi, Emmanuel J Favaloro
The term 'critical values' can be defined to entail laboratory test results which significantly lie outside the normal (reference) range and necessitate immediate reporting to safeguard patient health, as well as those displaying a highly and clinically significant variation compared to previous data. The identification and effective communication of "highly pathological" values has engaged the minds of many clinicians, healthcare and laboratory professionals for decades, since these activities are vital to good laboratory practice...
December 31, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/28031220/pathological-ponto-cerebello-thalamo-cortical-activations-in-primary-orthostatic-tremor-during-lying-and-stance
#6
Florian Schöberl, Katharina Feil, Guoming Xiong, Peter Bartenstein, Christian la Fougére, Klaus Jahn, Thomas Brandt, Michael Strupp, Marianne Dieterich, Andreas Zwergal
Primary orthostatic tremor is a rare neurological disease characterized mainly by a high frequency tremor of the legs while standing. The aim of this study was to identify the common core structures of the oscillatory circuit in orthostatic tremor and how it is modulated by changes of body position. Ten patients with orthostatic tremor and 10 healthy age-matched control subjects underwent a standardized neurological and neuro-ophthalmological examination including electromyographic and posturographic recordings...
January 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28007541/calcineurin-signaling-in-the-heart-the-importance-of-time-and-place
#7
Valentina Parra, Beverly A Rothermel
The calcium-activated protein phosphatase, calcineurin, lies at the intersection of protein phosphorylation and calcium signaling cascades, where it provides an essential nodal point for coordination between these two fundamental modes of intracellular communication. In excitatory cells, such as neurons and cardiomyocytes, that experience rapid and frequent changes in cytoplasmic calcium, calcineurin protein levels are exceptionally high, suggesting that these cells require high levels of calcineurin activity...
December 20, 2016: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/27958200/update-on-pathology-of-ocular-parasitic-disease
#8
REVIEW
Dipankar Das, Varsha Ramachandra, Saidul Islam, Harsha Bhattacharjee, Jyotirmay Biswas, Akanksha Koul, Panna Deka, Apurba Deka
Parasites are a group of eukaryotic organisms that may be free-living or form a symbiotic or parasitic relationship with the hosts. Consisting of over 800,000 recognized species, parasites may be unicellular (Protozoa) or multicellular (helminths and arthropods). The association of parasites with human population started long before the emergence of civilization. Parasitic zoonotic diseases are prevalent worldwide including India. Appropriate epidemiological data are lacking on existing zoonotic parasitic diseases, and newer diseases are emerging in our scenario...
November 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27941477/diaphragm-sparing-nerve-blocks-for-shoulder-surgery
#9
De Q H Tran, Maria Francisca Elgueta, Julian Aliste, Roderick J Finlayson
Shoulder surgery can result in significant postoperative pain. Interscalene brachial plexus blocks (ISBs) constitute the current criterion standard for analgesia but may be contraindicated in patients with pulmonary pathology due to the inherent risk of phrenic nerve block and symptomatic hemidiaphragmatic paralysis. Although ultrasound-guided ISB with small volumes (5 mL), dilute local anesthetic (LA) concentrations, and LA injection 4 mm lateral to the brachial plexus have been shown to reduce the risk of phrenic nerve block, no single intervention can decrease its incidence below 20%...
January 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/27920066/new-concepts-for-an-old-problem-the-diagnosis-of-endometrial-hyperplasia
#10
REVIEW
Peter A Sanderson, Hilary O D Critchley, Alistair R W Williams, Mark J Arends, Philippa T K Saunders
BACKGROUND: Endometrial hyperplasia (EH) is a uterine pathology representing a spectrum of morphological endometrial alterations. It is predominantly characterized by an increase in the endometrial gland-to-stroma ratio when compared to normal proliferative endometrium. The clinical significance of EH lies in the associated risk of progression to endometrioid endometrial cancer (EC) and 'atypical' forms of EH are regarded as premalignant lesions. Traditional histopathological classification systems for EH exhibit wide and varying degrees of diagnostic reproducibility and, as a consequence, standardized patient management can be challenging...
December 4, 2016: Human Reproduction Update
https://www.readbyqxmd.com/read/27915419/necrotizing-meningoencephalitis-caused-by-sarcocystis-falcatula-in-bare-faced-ibis-phimosus-infuscatus
#11
Guilherme Konradt, Matheus Viezzer Bianchi, Ronaldo Viana Leite-Filho, Bruna Zafalon da Silva, Rodrigo Martins Soares, Saulo Petinatti Pavarini, David Driemeier
The infection by S. falcatula is commonly associated with respiratory disease in captive psittacine birds, with a few case reports of this protozoan causing encephalitis in wild birds. We describe the clinical, pathological, and molecular aspects of an infection by S. falcatula in a bare-faced ibis (Phimosus infuscatus). Clinically, wing paralysis and mild motor incoordination were observed. At necropsy, the telencephalic cortex showed multifocal to coalescing yellowish soft areas. Histologically, multifocal to coalescent nonsuppurative necrotizing meningoencephalitis of telencephalic cortex, cerebellum, and brainstem was observed...
December 3, 2016: Parasitology Research
https://www.readbyqxmd.com/read/27859271/genetics-meets-pathology-an-increasingly-important-relationship
#12
David T Bonthron, William D Foulkes
The analytical power of modern methods for DNA analysis has outstripped our capability to interpret and understand the data generated. To make good use of this genomic data in a biomedical setting (whether for research or diagnosis), it is vital that we understand the mechanisms through which mutations affect biochemical pathways and physiological systems. This lies at the centre of what genetics is all about, and it is the reason why genetics and genomics should go hand in hand whenever possible. In this Annual Review Issue of The Journal of Pathology, we have assembled a collection of 16 expert reviews covering a wide range of topics...
January 2017: Journal of Pathology
https://www.readbyqxmd.com/read/27846305/time-to-decide-dynamical-analysis-predicts-partial-tip-stalk-patterning-states-arise-during-angiogenesis
#13
Lakshmi Venkatraman, Erzsébet Ravasz Regan, Katie Bentley
Angiogenesis is a highly dynamic morphogenesis process; however, surprisingly little is known about the timing of the different molecular processes involved. Although the role of the VEGF-notch-DLL4 signaling pathway has been established as essential for tip/stalk cell competition during sprouting, the speed and dynamic properties of the underlying process at the individual cell level has not been fully elucidated. In this study, using mathematical modeling we investigate how specific, biologically meaningful, local conditions around and within an individual cell can influence their unique tip/stalk phenotype switching kinetics...
2016: PloS One
https://www.readbyqxmd.com/read/27831595/prevalence-of-mental-health-problems-in-sentenced-men-in-prisons-from-andaluc%C3%A3-a-spain
#14
M López, F J Saavedra, A López, M Laviana
OBJECTIVES: To estimate the prevalence of different mental health problems in men serving prison sentences in Andalusia. METHODS: Descriptive, cross-sectional study of a random sample of 472 men interned in two prisons located in Andalusia. We collected socio-demographic and general criminal and penitentiary data, and we identified mental health problems with two validated instruments for epidemiological research in mental health: the SCID-I interview to diagnose Axis 1 disorders of the DSM-IV and the self-applied questionnaire IPDE to estimate personality disorders...
December 2016: Revista Española de Sanidad Penitenciaria
https://www.readbyqxmd.com/read/27802002/robot-assisted-laparoscopic-radical-prostatectomy-with-early-retrograde-release-of-the-neurovascular-bundle-and-endopelvic-fascia-sparing
#15
George Augusto Monteiro Lins de Albuquerque, Giuliano Betoni Guglielmetti, Maurício Dener Cordeiro, William Carlos Nahas, Rafael Ferreira Coelho
INTRODUCTION: Robotic-assisted radical prostatectomy (RAP) is the dominant minimally invasive surgical treatment for patients with localized prostate cancer. The introduction of robotic assistance has the potential to improve surgical outcomes and reduce the steep learning curve associated with conventional laparoscopic radical prostatectomy. The purpose of this video is to demonstrate the early retrograde release of the neurovascular bundle without open the endopelvic fascia during RAP...
November 2, 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/27790599/molecular-classification-of-oral-squamous-cell-carcinoma
#16
REVIEW
Radhika Manoj Bavle, Reshma Venugopal, Paremala Konda, Sudhakara Muniswamappa, Soumya Makarla
Oral Squamous Cell Carcinoma (OSCC) is the commonest tumour in the oro-facial region with increasing incidence in the recent years. The disease is challenging as it still depicts a high morbidity and mortality rate. Clinico-pathological data, tumour site, pathologic site tumor, lymphnode, metastasis (TNM) staging, histological grade, invasion, perineural invasion and metastasis have been evaluated to a great depth in relation to OSCC. Co-morbidity factors like use of tobacco, alcohol consumption and various other factors including genetic predisposition have been looked at for finding a suitable treatment protocol...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27785313/preoperative-chemoradiation-in-locally-advanced-rectal-cancer-efficacy-and-safety
#17
Evangelia Peponi, Vlassios Skloupiotis, Dimitris Tsironis, Ifigenia Tasiou, Antonio Capizzello, Chris Tsironis, Konstantinos E Tsimoyiannis, Evita Pitouli, Evangelos Tsimoyiannis, Pericles Tsekeris
BACKGROUND: Preoperative chemoradiation (CRT) is considered the standard of care in the management of stage II/III rectal cancer. The aim of this retrospective study was to assess the efficacy and safety of preoperative CRT in our patient cohort with locally advanced rectal adenocarcinoma. METHODS: Forty patients with cT3-4N0-2M0 adenocarcinoma of the lower (n = 26) and mid/upper (n = 14) rectum were enrolled in this study between 2001 and 2012. Radiotherapy (RT) was given to the pelvis...
December 2015: Gastroenterology Research
https://www.readbyqxmd.com/read/27769631/evolution-of-the-%C3%AE-adrenoreceptors-in-vertebrates
#18
Kattina Zavala, Michael W Vandewege, Federico G Hoffmann, Juan C Opazo
The study of the evolutionary history of genes related to human disease lies at the interface of evolution and medicine. These studies provide the evolutionary context on which medical researchers should work, and are also useful in providing information to suggest further genetic experiments, especially in model species where genetic manipulations can be made. Here we studied the evolution of the β-adrenoreceptor gene family in vertebrates with the aim of adding an evolutionary framework to the already abundant physiological information...
January 1, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/27765374/copper-supplementation-amplifies-the-anti-tumor-effect-of-curcumin-in-oral-cancer-cells
#19
Hui-Mei Lee, Vyomesh Patel, Lie-Fen Shyur, Wai-Leng Lee
BACKGROUND: Oral cancer is the sixth most common cancer worldwide and 90% of oral malignancies are caused by oral squamous cell carcinoma (OSCC). Curcumin, a phytocompound derived from turmeric (Curcuma longa) was observed to have anti-cancer activity which can be developed as an alternative treatment option for OSCC. However, OSCC cells with various clinical-pathological features respond differentially to curcumin treatment. HYPOTHESIS: Intracellular copper levels have been reported to correlate with tumor pathogenesis and affect the sensitivity of cancer cells to cytotoxic chemotherapy...
November 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27764021/descemet-membrane-detachment-during-cataract-surgery-etiology-and-management
#20
C Andres Benatti, Jeffrey Z Tsao, Natalie A Afshari
PURPOSE OF REVIEW: The review updates the mechanisms, clinical presentations, diagnoses, and managements of Descemet membrane detachment during cataract surgery. RECENT FINDINGS: The advent of new imaging techniques such as anterior segment optical coherence tomography and better comprehension of the clinical and pathological aspects of detachment have improved the diagnosis and treatment of this complication to the extent that the first algorithms and protocols have been proposed...
January 2017: Current Opinion in Ophthalmology
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