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https://www.readbyqxmd.com/read/29058033/greater-rheumatoid-arthritis-joint-improvement-with-more-subjects-achieving-response-across-improvement-categories-using-novel-versus-existing-ultrasound-methods
#1
York Kiat Tan, John C Allen, Weng Kit Lye, Li-Ching Chew, Julian Thumboo
We compared the change in joint inflammation and the proportion of subjects achieving threshold levels of improvement using the existing methods employing ultrasonography on pre-determined joint sites versus novel methods. These novel methods select the most affected joints based on (i) ultrasonography-the Individualized-Ultrasound (IUS) method, or (ii) ultrasonography and clinical joint assessment-the individualized-Composite-Ultrasound (ICUS) method. Mean 3-month change in total inflammation score (ΔTIS) and 95% CI was computed for each method on 24 RA subjects initiated or escalated on treatment...
October 20, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29055780/pregnancy-outcomes-associated-with-extended-use-of-the-52-mg-20%C3%AE-g-day-levonorgestrel-releasing-intrauterine-system-beyond-60months-a-chart-review-of-776-women-in-brazil
#2
Luis Bahamondes, Arlete Fernandes, M Valeria Bahamondes, Cassia T Juliato, Moazzam Ali, Ilza Monteiro
OBJECTIVE: To assess the contraceptive performance of the 52-mg 20 μg/day levonorgestrel-releasing intrauterine system (LNG-IUS, Mirena, Bayer Oy, Turku, Finland) among women who maintain the same device without changes after 60months. STUDY DESIGN: This is a chart review study in which we assessed the charts of 766 women who continue the same LNG-IUS for contraception beyond 60months. The women were evaluated at the Family Planning clinic, University of Campinas Medical School, Campinas, SP, Brazil from November 1990 to March 2011...
October 18, 2017: Contraception
https://www.readbyqxmd.com/read/29043893/considerations-on-risk-of-bacterial-vaginosis-trichomonas-vaginalis-and-candida-albicans-infection-among-new-users-of-combined-hormonal-contraception-vs-lng-ius
#3
Ahmed M Abbas, Asmaa S Shaltout
No abstract text is available yet for this article.
October 18, 2017: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/29038072/amenorrhea-rates-and-predictors-during-one-year-of-levonorgestrel-52mg-intrauterine-system-use
#4
Philip D Darney, Gretchen S Stuart, Michael A Thomas, Carrie Cwiak, Andrea Olariu, Mitchell D Creinin
OBJECTIVE: Evaluate amenorrhea patterns and predictors of amenorrhea during the first year after levonorgestrel 52mg intrauterine system (IUS) placement. STUDY DESIGN: This cohort analysis includes 1714 nulliparous and parous women who received a Liletta® levonorgestrel 52mg IUS in a multicenter trial to evaluate efficacy and safety for up to 8years. Participants maintained a daily diary with bleeding information. We assessed bleeding patterns in 90-day intervals; amenorrhea was defined as no bleeding or spotting in the preceding 90days...
October 13, 2017: Contraception
https://www.readbyqxmd.com/read/29037063/barriers-to-self-management-in-depressed-women-with-type-2-diabetes
#5
Monique M Ridosh, Gayle Roux, Meghan Meehan, Sue Penckofer
Purpose To describe the impact of family functioning on the self-management of type 2 diabetes (T2DM) and depression in a subsample of women who completed a randomized clinical trial using vitamin D3 (5000 or 50,000 IUs weekly) for depression treatment. Background Women are at higher risk for increased severity of T2DM when experiencing depression. Methods Narrative inquiry was used. A semi-structured interview was conducted to understand helpful strategies and barriers in managing T2DM and depression. In addition, women were asked their meaning of family quality of life (FQOL)...
January 1, 2017: Canadian Journal of Nursing Research, Revue Canadienne de Recherche en Sciences Infirmières
https://www.readbyqxmd.com/read/28977379/single-centre-experience-with-the-frozen-elephant-trunk-technique-in-251-patients-over-15%C3%A2-years
#6
Malakh Shrestha, Andreas Martens, Tim Kaufeld, Erik Beckmann, Sebastian Bertele, Heike Krueger, Julia Neuser, Felix Fleissner, Fabio Ius, Firas Abd Alhadi, Jasmin Hanke, Jan D Schmitto, Serghei Cebotari, Matthias Karck, Axel Haverich, Ajay Chavan
OBJECTIVES: Our goal was to present our 15-year experience (2001-2015) with the frozen elephant trunk (FET) technique. METHODS: A total of 251 patients (82 with aortic aneurysms, 96 with acute aortic dissection type A, 4 with acute type B dissections, 52 with chronic aortic dissection type A, 17 with chronic type B dissection and 67 redo cases) underwent FET implantation with either the custom-made Chavan-Haverich ( n  = 66), the Jotec E-vita ( n  = 31) or the Vascutek Thoraflex hybrid ( n  = 154) prosthesis...
August 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28971583/novel-joint-selection-methods-can-reduce-sample-size-for-rheumatoid-arthritis-clinical-trials-with-ultrasound-endpoints
#7
John C Allen, Julian Thumboo, Weng Kit Lye, Philip G Conaghan, Li-Ching Chew, York Kiat Tan
OBJECTIVES: To determine whether novel methods of selecting joints through (i) ultrasonography (individualized-ultrasound [IUS] method), or (ii) ultrasonography and clinical examination (individualized-composite-ultrasound [ICUS] method) translate into smaller rheumatoid arthritis (RA) clinical trial sample sizes when compared to existing methods utilizing predetermined joint sites for ultrasonography. METHODS: Cohen's effect size (ES) was estimated (ES^) and a 95% CI (ES^L, ES^U) calculated on a mean change in 3-month total inflammatory score for each method...
October 3, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28959876/ultrasound-assisted-awake-epilepsy-surgery-for-type-iib-focal-cortical-dysplasia-in-eloquent-areas
#8
Matteo Martinoni, Gianluca Marucci, Stefano Meletti, Lilia Volpi, Roberto Michelucci, Marco Giulioni
INTRODUCTION: Focal cortical dysplasia (FCD) type IIb is a frequent cause of pharmacoresistant epilepsy. However, intraoperative identification of the pathological tissue still remains a challenge despite the use of neuronavigation, particularly when it lies in eloquent areas. CASE REPORT: We here report a case of intraoperative identification of a right frontal FCD type IIB through ultrasound assisted neuronavigation during awake surgery in a patient with drug-resistant epilepsy...
September 28, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/28915701/comparison-among-fertility-sparing-therapies-for-well-differentiated-early-stage-endometrial-carcinoma-and-complex-atypical-hyperplasia
#9
REVIEW
Qing Zhang, Gonghua Qi, Margaux J Kanis, Ruifen Dong, Baoxia Cui, Xingsheng Yang, Beihua Kong
OBJECTIVE: To compare fertility-sparing therapies including oral progestogens, hysteroscopic resection (HR), and the levonorgestrel- releasing intrauterine system (LNG-IUS) in achieving disease regression, recurrence and live birth rate in well differentiate early-stage endometrial carcinoma (eEC) and complex atypical hyperplasia(CAH). STUDY DESIGN: This was a meta-analysis of previous studies focus on the fertility-sparing therapy for well differentiate early-stage endometrial carcinoma (eEC) and complex atypical hyperplasia (CAH)...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28913650/does-levonorgestrel-releasing-intrauterine-system-increase-breast-cancer-risk-in-peri-menopausal-women-an-hmo-perspective
#10
Nava Siegelmann-Danieli, Itzhak Katzir, Janet Vesterman Landes, Yaakov Segal, Rachel Bachar, Hadas Rotem Rabinovich, Martin Bialik, Joseph Azuri, Avi Porath, Yossef Lomnicky
PURPOSE: To evaluate the association between levonorgestrel-releasing intrauterine system (LNG-IUS) use and breast cancer (BC) risk. METHODS: A cohort of all Maccabi Healthcare Services (MHS) female members aged 40-50 years between 1/2003 and 12/2013 was used to identify LNG-IUS users as "cases," and 2 age-matched non-users as "controls." Exclusion criteria included: prior BC diagnosis, prior (5 years pre-study) and subsequent treatment with other female hormones or prophylactic tamoxifen...
September 14, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28892980/evaluating-the-efficacy-of-levonorgestrel-intrauterine-system-and-danazol-for-relief-of-postoperative-pain-in-endometriosis
#11
Ashima Taneja, Satinder Kaur, R K Soni, Bhanupriya, Jaspreet Kaur, Laveen Singla
INTRODUCTION: Endometriosis is an oestrogen-dependent disorder, manifests during reproductive years and is associated with pain and infertility. There is considerable debate about the effectiveness of various interventions for pain relief. AIM: To evaluate the efficacy of Levonorgestrel Intrauterine System (LNG-IUS) and Danazol in postoperative pain relief for patients with endometriosis. MATERIALS AND METHODS: Hundred patients with diagnosis of endometriosis, who were treated laparoscopically, entered the study to receive either danazol (600 mg once daily) or LNG-IUS (inserted during immediate post operative period) postsurgery, for pain relief...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28844878/overcoming-barriers-to-levonorgestrel-releasing-intrauterine-system-placement-an-evaluation-of-placement-of-lng-ius-8-using-the-modified-evoinserter%C3%A2-in-a-majority-nulliparous-population
#12
Kristina Gemzell-Danielsson, Dan Apter, Eeva Lukkari-Lax, Katrin Roth, Marco Serrani
OBJECTIVES: To report placement success rate, and ease and pain associated with placement, of the levonorgestrel-releasing intrauterine system (LNG-IUS) 8 using the modified EvoInserter® placement device. STUDY DESIGN: This was a pooled analysis using data from three previously reported Phase III studies in nulliparous (83.3%) or parous (16.7%) women aged 12-35years (N=965). LNG-IUS 8 was placed using the modified Evolnserter®. The main outcomes assessed were placement success, ease of placement as reported by healthcare professionals (HCPs), pain at placement as reported by participants, and assessment of the EvoInserter® placement device by HCPs...
August 24, 2017: Contraception
https://www.readbyqxmd.com/read/28838100/long-term-results-of-the-mitroflow-aortic-pericardial-bioprosthesis-in-over-800-patients-limited-durability-and-mechanisms-of-dysfunction
#13
Fabio Ius, Julia Schulz, Mazen Roumieh, Felix Fleissner, Issam Ismail, Igor Tudorache, Gregor Warnecke, Andreas Martens, Malakh Shrestha, Dietmar Boethig, Axel Haverich, Serghei Cebotari
OBJECTIVES: The Mitroflow aortic pericardial bioprosthesis was widely employed in the past. However, some authors have recently reported early structural valve deterioration (SVD) of the Mitroflow LA/LXA model. Thus, we reviewed our experience with the Mitroflow bioprosthesis and studied the risk factors for SVD and mortality. METHODS: Records of patients who underwent aortic valve replacement with a Mitroflow bioprosthesis between November 2005 and January 2015 were retrospectively evaluated with Kaplan-Meier, Cox-regression and multistate analysis...
August 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28833891/relationship-between-user-satisfaction-with-the-levonorgestrel-releasing-intrauterine-system-and-bleeding-patterns
#14
Nelsilene M Carvalho, Victoria Chou, Waleska Modesto, Deborah Margatho, Elaine A L Garcia, Luis Bahamondes
AIM: Satisfaction with a contraceptive method constitutes an important factor in its acceptance and long-term use. The objective of this study was to assess the relationship between user satisfaction with the 20-μg/day levonorgestrel-releasing intrauterine system (LNG-IUS) and the bleeding patterns reported at two different time-points during follow-up. METHODS: A total of 251 LNG-IUS users aged 18-45 years were invited to answer a questionnaire on their return to the clinic for a routine follow-up visit and again 1 year later...
August 17, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28826801/postplacental-intrauterine-device-expulsion-by-12-weeks-a%C3%A2-prospective-cohort-study
#15
Lisa M Goldthwaite, Jeanelle Sheeder, Jennifer Hyer, Kristina Tocce, Stephanie B Teal
BACKGROUND: An intrauterine device placed immediately following a delivery can serve as an effective and safe contraceptive strategy in the postpartum period. There is limited evidence that the levonorgestrel intrauterine system may have a higher rate of expulsion compared to the copper intrauterine device; however, rates of expulsion for these 2 intrauterine device types have not been compared directly. OBJECTIVE: We sought to compare expulsion rates by 12 weeks' postpartum for the levonorgestrel intrauterine system and copper intrauterine device...
August 19, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28796898/comparison-of-the-levonorgestrel-releasing-intrauterine-system-hysterectomy-and-endometrial-ablation-for-heavy-menstrual-bleeding-in-a-decision-analysis-model
#16
REVIEW
Michelle Louie, Jennifer Spencer, Stephanie Wheeler, Victoria Ellis, Tarek Toubia, Lauren D Schiff, Matthew T Siedhoff, Janelle K Moulder
BACKGROUND: A better understanding of the relative risks and benefits of common treatment options for abnormal uterine bleeding (AUB) can help providers and patients to make balanced, evidence-based decisions. OBJECTIVES: To provide comparative estimates of clinical outcomes after placement of levonorgestrel-releasing intrauterine system (LNG-IUS), ablation, or hysterectomy for AUB. SEARCH STRATEGY: A PubMED search was done using combinations of search terms related to abnormal uterine bleeding, LNG-IUS, hysterectomy, endometrial ablation, cost-benefit analysis, cost-effectiveness, and quality-adjusted life years...
August 10, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28774663/fast-track-vs-delayed-insertion-of-the-levonorgestrel-releasing-intrauterine-system-after-early-medical-abortion-a-randomized-trial
#17
Riina Korjamo, Maarit Mentula, Oskari Heikinheimo
OBJECTIVE: To compare levonorgestrel (LNG) 52-mg intrauterine system (IUS) expulsion rates with fast-track (≤3 days) or delayed (2-4 weeks) insertion following mifepristone and misoprostol medical abortion. STUDY DESIGN: In this pilot trial, we randomized 108 women at ≤63 days' gestation to fast-track (n=55) or delayed (n=53) insertion. Follow-up visits occurred at 2-4 weeks, 3 months and 1 year. We assessed total and partial expulsion at 3 months and 1 year, adverse effects and bleeding profiles...
August 5, 2017: Contraception
https://www.readbyqxmd.com/read/28755966/characteristics-of-idiopathic-urethral-strictures-a-link-to-remote-perineal-trauma
#18
Boyd R Viers, Travis J Pagliara, Charles A Rew, Lauren Folgosa Cooley, Christine Y Shiang, Jeremy M Scott, Allen F Morey
OBJECTIVE: To characterize the physical features and reconstructive outcomes of a series of idiopathic urethral stricture (IUS) cases in an effort to elucidate the nature of this common, yet poorly understood entity. METHODS: We retrospectively reviewed our urethroplasty database to identify men undergoing initial urethral reconstruction from 2007-2014 at one of three hospitals (N=514). Patients were stratified by stricture etiology including IUS, acute trauma, iatrogenic, hypospadias, balanitis xerotica obliterans, and radiation...
July 26, 2017: Urology
https://www.readbyqxmd.com/read/28754438/cost-effectiveness-of-treatments-for-heavy-menstrual%C3%A2-bleeding
#19
Jennifer C Spencer, Michelle Louie, Janelle K Moulder, Victoria Ellis, Lauren D Schiff, Tarek Toubia, Matthew T Siedhoff, Stephanie B Wheeler
BACKGROUND: Heavy menstrual bleeding affects up to one third of women in the United States, resulting in a reduced quality of life and significant cost to the health care system. Multiple treatment options exist, offering different potential for symptom control at highly variable initial costs, but the relative value of these treatment options is unknown. OBJECTIVE: The objective of the study was to evaluate the relative cost-effectiveness of 4 treatment options for heavy menstrual bleeding: hysterectomy, resectoscopic endometrial ablation, nonresectoscopic endometrial ablation, and the levonorgestrel-releasing intrauterine system...
July 25, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28749780/the-prevalence-of-extended-spectrum-beta-lactamase-producing-multidrug-resistant-escherichia-coli-in-poultry-chickens-and-variation-according-to-farming-practices-in-punjab-india
#20
Charles H Brower, Siddhartha Mandal, Shivdeep Hayer, Mandeep Sran, Asima Zehra, Sunny J Patel, Ravneet Kaur, Leena Chatterjee, Savita Mishra, B R Das, Parminder Singh, Randhir Singh, J P S Gill, Ramanan Laxminarayan
BACKGROUND: Agricultural use of antimicrobials in subtherapeutic concentrations is increasing in response to the rising demand for food animal products worldwide. In India, the use of antimicrobials in food animal production is unregulated. Research suggests that many clinically important antimicrobials are used indiscriminately. This is the largest study to date in India that surveys poultry production to test for antimicrobial resistance and the occurrence of extended-spectrum (ESBLs) modulated by farming and managerial practices...
July 20, 2017: Environmental Health Perspectives
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