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Mild brain injury

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https://www.readbyqxmd.com/read/29166203/temporal-profile-of-care-following-mild-traumatic-brain-injury-predictors-of-hospital-admission-follow-up-referral-and-six-month-outcome
#1
John K Yue, Ethan A Winkler, Sourabh Sharma, Mary J Vassar, Jonathan J Ratcliff, Frederick K Korley, Seth A Seabury, Adam R Ferguson, Hester F Lingsma, Sacha Meeuws, Opeolu M Adeoye, Jonathan W Rick, Caitlin K Robinson, Siena M Duarte, Esther L Yuh, Pratik Mukherjee, Sureyya S Dikmen, Thomas W McAllister, Ramon Diaz-Arrastia, Alex B Valadka, Wayne A Gordon, David O Okonkwo, Geoffrey T Manley
OBJECTIVE: To investigate the clinical management and medical follow-up of patients with mild traumatic brain injury (mTBI) presenting to emergency departments (EDs). METHODS: Overall, 168 adult patients with mTBI from the prospective, multicentre Transforming Research and Clinical Knowledge in TBI (TRACK-TBI) Pilot study with Glasgow Coma Scale (GCS) 13-15, no polytrauma and alive at six months were included. Predictors for hospital admission, three-month follow-up referral and six-month functional disability (Glasgow Outcome Scale-Extended (GOSE) ≤ 6) were analysed using multivariable regression...
2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29163337/disrupted-gamma-synchrony-after-mild-traumatic-brain-injury-and-its-correlation-with-white-matter-abnormality
#2
Chao Wang, Michelle E Costanzo, Paul E Rapp, David Darmon, Dominic E Nathan, Kylee Bashirelahi, Dzung L Pham, Michael J Roy, David O Keyser
Mild traumatic brain injury (mTBI) has been firmly associated with disrupted white matter integrity due to induced white matter damage and degeneration. However, comparatively less is known about the changes of the intrinsic functional connectivity mediated via neural synchronization in the brain after mTBI. Moreover, despite the presumed link between structural and functional connectivity, no existing studies in mTBI have demonstrated clear association between the structural abnormality of white matter axons and the disruption of neural synchronization...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29163326/systematic-review-of-traumatic-brain-injuries-in-baseball-and-softball-a-framework-for-prevention
#3
Michael D Cusimano, Alice Zhu
Background: Traumatic brain injuries (TBIs) are an important public health challenge. The classification of baseball and softball as low contact sports and their association with extremity injuries cause individuals to overlook the risk of TBI in baseball and softball. Purpose: To summarize our knowledge of the epidemiology and risk factors of TBIs associated with baseball and softball with an aim to better design and implement preventive strategies. Methods: A search algorithm containing keywords that were synonymous to the terms "TBI," "baseball" was applied to the following nine databases: MEDLINE, Scopus, PubMed, EMBASE, CINAHL, Healthstar, PsychINFO, AMED, Cochrane library...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29161151/an-index-of-decline-or-recovery-following-nonimpact-and-impact-mtbi
#4
James Ernest Sweeney, Andrew M Johnson
This study investigated the degree to which litigants/insurance claimants sustaining Nonimpact mild traumatic brain injury (mTBI) in motor vehicle accidents differed from compensation-seeking motor vehicle accident victims that suffered Impact mTBI in terms of neuropsychological decline/recovery, using as a control litigants/insurance claimants that did not experience mTBI in motor vehicle accidents. A clinical index (C-Voc) was employed as the dependent measure for decline/recovery, consisting of T-score algebraic differences between a highly sensitive neurocognitive measure (Category Test) and a relatively insensitive "hold" measure (Wechsler Adult Intelligence Scale Vocabulary subtest)...
November 21, 2017: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/29160926/electro-mechanical-response-of-a-3d-nerve-bundle-model-to-mechanical-loads-leading-to-axonal-injury
#5
I Cinelli, M Destrade, M Duffy, P McHugh
OBJECTIVE: Traumatic brain injuries and damage are major causes of death and disability. We propose a 3D fully coupled electro-mechanical model of a nerve bundle to investigate the electrophysiological impairments due to trauma at the cellular level. METHODS: The coupling is based on a thermal analogy of the neural electrical activity by using the finite element software Abaqus CAE 6.13-3. The model includes a real-time coupling, modulated threshold for spiking activation and independent alteration of the electrical properties for each 3-layer fibre within a nerve bundle as a function of strain...
November 21, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29160141/effects-of-mild-blast-traumatic-brain-injury-on-cerebral-vascular-histopathological-and-behavioral-outcomes-in-rats
#6
Uylissa A Rodriguez, Yaping Zeng, Donald James Deyo, Margaret O Parsley, Bridget E Hawkins, Donald S Prough, Douglas DeWitt
To determine the effects of mild blast-induced traumatic brain injury (bTBI), several groups of rats were subjected to blast injury or sham injury in a compressed air-driven shock tube. The effects of bTBI on relative cerebral perfusion (laser Doppler flowmetry, LDF), mean arterial blood pressure (MAP) cerebral vascular resistance were measured for two hrs post-bTBI. Dilator responses to reduced intravascular pressure were measured in isolated middle cerebral arterial (MCA) segments, ex vivo, 30 and 60 min post-bTBI...
November 21, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29159958/evaluation-of-a-low-risk-mild-traumatic-brain-injury-and-intracranial-hemorrhage-emergency-department-observation-protocol
#7
Brian J Yun, Pierre Borczuk, Lulu Wang, Stephen Dorner, Benjamin A White, Ali S Raja
OBJECTIVES: Among emergency physicians, there is wide variation in admitting practices for patients who suffered a mild traumatic brain injury (TBI) with an intracranial hemorrhage (ICH). The purpose of this study was to evaluate the effects of implementing a protocol in the emergency department (ED) observation unit for patients with mild TBI and ICH. METHODS: This retrospective cohort study was approved by the Institutional Review Board. Study subjects were patients ≥18 years of age with an International Classification of Diseases (ICD) code corresponding to a traumatic IC, and admitted to an ED observation unit (EDOU) of an urban, academic level 1 trauma center between February 1, 2015 and January 31, 2017...
November 20, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29157855/imaging-the-role-of-myelin-in-concussion
#8
REVIEW
Alexander Mark Weber, Carlos Torres, Alexander Rauscher
Myelin water imaging (MWI) provides mild traumatic brain injury (mTBI) researchers with a specific myelin biomarker and helps to further elucidate microstructural and microarchitectural changes of white matter after mTBI. Improvement of scanner hardware and software with the implementation of MWI across scanner platforms will likely result in increased research regarding the role of myelin in traumatic brain injury (TBI). Future research should include detailed investigation of myelin between 2 weeks and 2 months after injury, the use of MWI in moderate and severe TBI, and investigation of the role of myelin in chronic TBI...
February 2018: Neuroimaging Clinics of North America
https://www.readbyqxmd.com/read/29157854/pet-and-single-photon-emission-computed-tomography-in-brain-concussion
#9
REVIEW
Cyrus A Raji, Theodore A Henderson
This article offers an overview of the application of PET and single photon emission computed tomography brain imaging to concussion, a type of mild traumatic brain injury and traumatic brain injury, in general. The article reviews the application of these neuronuclear imaging modalities in cross-sectional and longitudinal studies. Additionally, this article frames the current literature with an overview of the basic physics and radiation exposure risks of each modality.
February 2018: Neuroimaging Clinics of North America
https://www.readbyqxmd.com/read/29157850/conventional-computed-tomography-and-magnetic-resonance-in-brain-concussion
#10
REVIEW
Juan Nicolas Useche, Sonia Bermudez
Conventional neuroimaging is still the mainstay in the assessment of the acute, follow-up, and chronic settings of concussion and mild traumatic brain injury (mTBI). Computed tomography (CT) is preferred for the initial assessment of acute mTBI, repeat evaluation in acute mTBI with neurologic deterioration, and cautious use in children with mTBI. Clinical rules have been developed to identify pediatric and adult patients with mTBI who can safely forego CT. Magnetic resonance (MR) imaging is mostly used in patients with acute mTBI when initial or follow-up CT is normal and there are persistent neurologic findings and in subacute or chronic mTBI...
February 2018: Neuroimaging Clinics of North America
https://www.readbyqxmd.com/read/29157848/diffusion-mr-imaging-in-mild-traumatic-brain-injury
#11
REVIEW
Maria J Borja, Sohae Chung, Yvonne W Lui
Remarkable advances have been made in the last decade in the use of diffusion MR imaging to study mild traumatic brain injury (mTBI). Diffusion imaging shows differences between mTBI patients and healthy control groups in multiple different metrics using a variety of techniques, supporting the notion that there are microstructural injuries in mTBI patients that radiologists have been insensitive to. Future areas of discovery in diffusion MR imaging and mTBI include larger longitudinal studies to better understand the evolution of the injury and unravel the biophysical meaning that the detected changes in diffusion MR imaging represent...
February 2018: Neuroimaging Clinics of North America
https://www.readbyqxmd.com/read/29157847/functional-mr-imaging-blood-oxygen-level-dependent-and-resting-state-techniques-in-mild-traumatic-brain-injury
#12
REVIEW
Scott Rosenthal, Matthew Gray, Hudaisa Fatima, Haris I Sair, Christopher T Whitlow
This article discusses mild traumatic brain injury (mTBI)-associated effects on brain functional connectivity assessed via resting-state functional MR (fMR) imaging. Several studies have reported acute post-injury default mode network hyperconnectivity, followed by a period of decreased connectivity before later connectivity normalization in some patients. Other studies have reported mTBI associated effects on connectivity that remain evident for up to 5-years or more. Discordance in the published literature regarding the direction of network connectivity changes (eg, increased versus decreased connectivity) may reflect differences in timing of data collection post-injury, as well as the need to standardize MR imaging acquisition protocols and processing methods...
February 2018: Neuroimaging Clinics of North America
https://www.readbyqxmd.com/read/29157846/definition-of-traumatic-brain-injury-neurosurgery-trauma-orthopedics-neuroimaging-psychology-and-psychiatry-in-mild-traumatic-brain-injury
#13
REVIEW
Mubashir Pervez, Ryan S Kitagawa, Tiffany R Chang
Traumatic brain injury (TBI) disrupts the normal function of the brain. This condition can adversely affect a person's quality of life with cognitive, behavioral, emotional, and physical symptoms that limit interpersonal, social, and occupational functioning. Although many systems exist, the simplest classification includes mild, moderate, and severe TBI depending on the nature of injury and the impact on the patient's clinical status. Patients with TBI require prompt evaluation and multidisciplinary management...
February 2018: Neuroimaging Clinics of North America
https://www.readbyqxmd.com/read/29157025/non-pharmacological-rehabilitation-interventions-for-concussion-in-children-a-scoping-review
#14
Danielle M Dobney, Matthew B Miller, Emily Tufts
PURPOSE: To summarise the extent, nature, and quality of current scholarly literature related to non-pharmacological, rehabilitation interventions following concussion, or mild traumatic brain injury in children. METHODS: An electronic search was conducted from 1987 to 24 October 2017. Studies were included if they met the following criteria: (1) full text, peer reviewed, and written in English, (2) original research, (3) diagnosed concussion or mild traumatic brain injury, (4) described the evaluation of an intervention, (5) the outcome was a concussion impairment, and (6) the mean/median age was under 19...
November 20, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29157017/comprehensive-assessment-of-shockwave-intensity-transcriptomic-biomarker-discovery-for-primary-blast-induced-mild-traumatic-brain-injury-using-the-mammalian-hair-follicle
#15
Jing Zhang, Rosalinda Knight, Yushan Wang, Thomas W Sawyer, Christopher J Martyniuk, Valerie S Langlois
OBJECTIVE: Primary blast-induced mild traumatic brain injury (mTBI) is an injury experienced during modern warfare due to exposure to the pressure waves produced by the detonation of explosives. With virtually no apparent physical damage or symptoms presented, there is a need for more objective and accessible mTBI biomarkers posing minimal invasiveness risk. METHODS: We measured the transcriptomic sensitivity of the hair follicles in relation to the severity of primary blast-derived TBI...
November 20, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29157007/prognostic-value-of-neuron-specific-enolase-nse-for-prediction-of-post-concussion-symptoms-following-a-mild-traumatic-brain-injury-a-systematic-review
#16
Eric Mercier, Pier-Alexandre Tardif, Peter A Cameron, Marcel Émond, Lynne Moore, Biswadev Mitra, Marie-Christine Ouellet, Jérôme Frenette, Elaine de Guise, Natalie Le Sage
BACKGROUND: This systematic review aimed to determine the prognostic value of neuron-specific enolase (NSE) to predict post-concussion symptoms following mild traumatic brain injury (TBI). METHODS: Seven databases were searched for studies evaluating the association between NSE levels and post-concussion symptoms assessed ≥ 3 months (persistent) or ≥ 7 days < 3 months (early) after mild TBI. Two researchers independently screened studies for inclusion, extracted data and appraised quality using the Quality in Prognostic Studies (QUIPS) tool...
November 20, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29156999/risk-factors-for-intracranial-lesions-and-mortality-in-older-patients-with-mild-traumatic-brain-injuries
#17
Ma Angustias Ibañez Pérez De La Blanca, Enrique Fernández Mondéjar, Francisco Javier Gómez Jimènez, Jóse María Alonso Morales, Ma Dolores Quijano Lombardo, Juan Luis Viso Rodriguez
PRIMARY OBJECTIVE: To identify risk factors for intracerebral lesion (ICL) in older adults with mild traumatic brain injury (MTBI) and evaluate the influence of comorbidities on outcomes. RESEARCH DESIGN: Prospective cohort study. METHODS AND PROCEDURES: Information was gathered on clinical history/examination, cranial computed tomography, admission Glasgow Coma Scale (GCS) score, analytical and coagulation findings, and mortality at 1 week post-discharge...
November 20, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29156991/repeated-mild-traumatic-brain-injury-produces-neuroinflammation-anxiety-like-behaviour-and-impaired-spatial-memory-in-mice
#18
John I Broussard, Laura Acion, Héctor De Jesús-Cortés, Terry Yin, Jeremiah K Britt, Ramiro Salas, Mauro Costa-Mattioli, Claudia Robertson, Andrew A Pieper, David B Arciniegas, Ricardo Jorge
PRIMARY OBJECTIVE: Repeated traumatic brain injuries (rmTBI) are frequently associated with debilitating neuropsychiatric conditions such as cognitive impairment, mood disorders, and post-traumatic stress disorder. We tested the hypothesis that repeated mild traumatic brain injury impairs spatial memory and enhances anxiety-like behaviour. RESEARCH DESIGN: We used a between groups design using single (smTBI) or repeated (rmTBI) controlled cranial closed skull impacts to mice, compared to a control group...
November 20, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29155224/medical-encounter-mental-health-diagnoses-non-fatal-injury-and-polypharmacy-indicators-of-risk-for-accident-death-in-the-us-army-enlisted-soldiers-2004-2009
#19
Lisa Lewandowski-Romps, Heather M Schroeder, Patricia A Berglund, Lisa J Colpe, Kenneth Cox, Keith Hauret, Jeffrey D Hay, Bruce Jones, Roderick J A Little, Colter Mitchell, Michael Schoenbaum, Paul Schulz, Murray B Stein, Robert J Ursano, Steven G Heeringa
Accidents are a leading cause of deaths in U.S. active duty personnel. Understanding accident deaths during wartime could facilitate future operational planning and inform risk prevention efforts. This study expands prior research, identifying health risk factors associated with U.S. Army accident deaths during the Afghanistan and Iraq war. Military records for 2004-2009 enlisted, active duty, Regular Army soldiers were analyzed using logistic regression modeling to identify mental health, injury, and polypharmacy (multiple narcotic and/or psychotropic medications) predictors of accident deaths for current, previously, and never deployed groups...
November 16, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/29152209/case-control-study-hyperbaric-oxygen-treatment-of-mild-traumatic-brain-injury-persistent-post-concussion-syndrome-and-post-traumatic-stress-disorder
#20
Paul G Harch, Susan R Andrews, Edward F Fogarty, Juliette Lucarini, Keith W Van Meter
Mild traumatic brain injury (TBI) persistent post-concussion syndrome (PPCS) and post-traumatic stress disorder (PTSD) are epidemic in United States Iraq and Afghanistan War veterans. Treatment of the combined diagnoses is limited. The aim of this study is to assess safety, feasibility, and effectiveness of hyperbaric oxygen treatments (HBOT) for mild TBI PPCS and PTSD. Thirty military subjects aged 18-65 with PPCS with or without PTSD and from one or more blast-induced mild-moderate traumatic brain injuries that were a minimum of 1 year old and occurred after 9/11/2001 were studied...
July 2017: Medical Gas Research
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