Sohae Chung, Tamar Bacon, Joseph F Rath, Alaleh Alivar, Santiago Coelho, Prin Amorapanth, Els Fieremans, Dmitry S Novikov, Steven R Flanagan, Joshua H Bacon, Yvonne W Lui
BACKGROUND AND PURPOSE: Because the corpus callosum connects the left and right hemispheres and a variety of WM bundles across the brain in complex ways, damage to the neighboring WM microstructure may specifically disrupt interhemispheric communication through the corpus callosum following mild traumatic brain injury. Here we use a mediation framework to investigate how callosal interhemispheric communication is affected by WM microstructure in mild traumatic brain injury. MATERIALS AND METHODS: Multishell diffusion MR imaging was performed on 23 patients with mild traumatic brain injury within 1 month of injury and 17 healthy controls, deriving 11 diffusion metrics, including DTI, diffusional kurtosis imaging, and compartment-specific standard model parameters...
April 18, 2024: AJNR. American Journal of Neuroradiology