Robert A Stern, Diana Trujillo-Rodriguez, Yorghos Tripodis, Surya V Pulukuri, Michael L Alosco, Charles H Adler, Laura J Balcer, Charles Bernick, Zachary Baucom, Kenneth L Marek, Michael D McClean, Keith A Johnson, Ann C McKee, Thor D Stein, Jesse Mez, Joseph N Palmisano, Jeffrey L Cummings, Martha E Shenton, Eric M Reiman
BACKGROUND: Exposure to repetitive head impacts (RHI) in American football players can lead to cognitive impairment and dementia due to neurodegenerative disease, particularly chronic traumatic encephalopathy (CTE). The pathognomonic lesion of CTE consists of perivascular aggregates of hyper-phosphorylated tau in neurons at the depths of cortical sulci. However, it is unclear whether exposure to RHI accelerates amyloid-β (Aβ) plaque formation and increases the risk for Alzheimer's disease (AD)...
October 5, 2023: Alzheimer's Research & Therapy