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Bruce L Wilkoff, Laurent Fauchier, Martin K Stiles, Carlos A Morillo, Sana M Al-Khatib, Jesœs Almendral, Luis Aguinaga, Ronald D Berger, Alejandro Cuesta, James P Daubert, Sergio Dubner, Kenneth A Ellenbogen, N A Mark Estes, Guilherme Fenelon, Fermin C Garcia, Maurizio Gasparini, David E Haines, Jeff S Healey, Jodie L Hurtwitz, Roberto Keegan, Christof Kolb, Karl-Heinz Kuck, Germanas Marinskis, Martino Martinelli, Mark McGuire, Luis G Molina, Ken Okumura, Alessandro Proclemer, Andrea M Russo, Jagmeet P Singh, Charles D Swerdlow, Wee Siong Teo, William Uribe, Sami Viskin, Chun-Chieh Wang, Shu Zhang
[This corrects the article DOI: 10.1016/j.joa.2015.12.001.].
October 2016: Journal of Arrhythmia
Daniel J Friedman, Haikun Bao, Erica S Spatz, Jeptha P Curtis, James P Daubert, Sana M Al-Khatib
BACKGROUND: -A prolonged PR interval is common among cardiac resynchronization therapy (CRT) candidates; however, the association between PR interval and outcomes is unclear, and data are conflicting. METHODS: -We conducted inverse probability weighted (IPW) analyses of 26,451 CRT eligible (EF≤35, QRS≥120ms) patients from the National Cardiovascular Data Registry ICD Registry to assess the association between a prolonged PR interval (≥230ms), receipt of CRT with defibrillator (CRT-D) versus implantable cardioverter defibrillator (ICD), and outcomes...
October 19, 2016: Circulation
Eric W Black-Maier, Sean D Pokorney, Adam S Barnett, Peter Liu, Peter Shrader, Jason Ng, Jeffrey J Goldberger, Wojiech Zareba, James P Daubert, Augustus O Grant, Jonathan P Piccini
AIMS: Antiarrhythmic medications for the treatment of atrial fibrillation (AF) have limited efficacy and rare but potentially life-threatening side effects. Ranolazine is an antianginal agent that may have antiarrhythmic activity in AF. METHODS AND RESULTS: Using the Duke Enterprise Data Unified Content Explorer database, we analysed a cohort of AF patients on ranolazine. Patients served as their own historic control. Electrocardiograms (ECGs) were analysed before and after ranolazine initiation to determine the effect of ranolazine on dominant frequency (DF), f-wave amplitude, and organizational index (OI)...
October 17, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Solène Le Pennec-Prigent, Erwan Flecher, Vincent Auffret, Guillaume Leurent, Jean-Claude Daubert, Christophe Leclercq, Philippe Mabo, Jean-Philippe Verhoye, Raphael P Martins
OBJECTIVES: Extracorporeal life support is used for patients with severe heart failure as a bridge to heart transplantation or recovery. We aimed at analyzing the efficacy and safety of extracorporeal life support to treat refractory arrhythmic storm responsible for cardiogenic shock in patients resistant to antiarrhythmic drugs. DESIGN: Retrospective study. SETTING: University Hospital of Rennes, France. PATIENTS: Patients with refractory arrhythmic storm admitted between January 2005 and March 2015...
October 14, 2016: Critical Care Medicine
Anna Lisa Crowley, Eric Yow, Huiman X Barnhart, Melissa A Daubert, Robert Bigelow, Daniel C Sullivan, Michael Pencina, Pamela S Douglas
BACKGROUND: There is no broadly accepted standard method for assessing the quality of echocardiographic measurements in clinical research reports, despite the recognized importance of this information in assessing the quality of study results. METHODS: Twenty unique clinical studies were identified reporting echocardiographic data quality for determinations of left ventricular (LV) volumes (n = 13), ejection fraction (n = 12), mass (n = 9), outflow tract diameter (n = 3), and mitral Doppler peak early velocity (n = 4)...
October 6, 2016: Journal of the American Society of Echocardiography
Christine M Tompkins, Scott McNitt, Bronislava Polonsky, James P Daubert, Paul J Wang, Arthur J Moss, Wojciech Zareba, Valentina Kutyifa
INTRODUCTION: Approximately 10-20% of ICD recipients receive inappropriate device therapies. The purpose of this study was to compare the frequency of inappropriate therapies (IT) between men and women enrolled in MADIT II and MADIT-CRT, and assess for potential adverse outcomes. METHODS: The electrograms for each ICD or CRT-D therapy, defined as either ATP or shock, were reviewed by adjudication committees for both studies. ICD therapy was considered inappropriate if it was delivered for reasons other than VT/VF...
October 2, 2016: Journal of Cardiovascular Electrophysiology
Vincent Galand, Dominique Pavin, Nathalie Behar, Vincent Auffret, Damien Fénéon, Albin Behaghel, Jean-Claude Daubert, Philippe Mabo, Raphaël P Martins
BACKGROUND: Pulmonary vein (PV) isolation, using cryoballoon or radiofrequency ablation, is the cornerstone therapy for symptomatic paroxysmal atrial fibrillation (AF) refractory to antiarrhythmic drugs. One-third of the patients have recurrences, mainly due to PV reconnections. AIMS: To describe the different locations of reconnection sites in patients who had previously undergone radiofrequency or cryoballoon ablation, and to compare the characteristics of the redo procedures in both instances...
September 28, 2016: Archives of Cardiovascular Diseases
Stephen Gaeta, James P Daubert
No abstract text is available yet for this article.
September 23, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Katherine Shats, Timothy Brindley, James Giordano
Ongoing developments in neuroscientific techniques and technologies-such as neuroimaging-offer potential for greater insight into human behavior and have fostered temptation to use these approaches in legal contexts. Neuroscientists are increasingly called on to provide expert testimony, interpret brain images, and thereby inform judges and juries who are tasked with determining the guilt or innocence of an individual. In this essay, we draw attention to the actual capabilities and limitations of currently available assessment neurotechnologies and examine whether neuroscientific evidence presents unique challenges to existing frameworks of evidence law...
October 2016: Cambridge Quarterly of Healthcare Ethics: CQ: the International Journal of Healthcare Ethics Committees
Claude Daubert, Philippe Mabo
No abstract text is available yet for this article.
August 17, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Raphaël P Martins, Vincent Galand, Edouard Colette, Nathalie Behar, Dominique Pavin, Christophe Leclercq, Jean-Claude Daubert, Philippe Mabo
Non-vitamin K oral anticoagulants (NOACs) are currently recommended for patients with nonvalvular atrial fibrillation since the publication of the 4 major pivotal trials evaluating the efficacy and safety of factor IIa and factor Xa inhibitors. The definition of nonvalvular atrial fibrillation is unclear, varying from one trial to another and even between North American and European guidelines, which is a source of uncertainties in clinical practice. However, many patients with atrial fibrillation present signs of valvular involvement, and clarification of this term is needed to not deny NOACs to patients based on the wrong perception that they may have valvular atrial fibrillation...
August 2016: American Heart Journal
Emily P Zeitler, Yongfei Wang, Kumar Dharmarajan, Kevin J Anstrom, Eric D Peterson, James P Daubert, Jeptha P Curtis, Sana M Al-Khatib
BACKGROUND: Patients with an unused or malfunctioning implantable cardioverter-defibrillator (ICD) lead may have the lead either abandoned or explanted; yet there are limited data on the comparative acute and longer-term safety of these 2 approaches. METHODS AND RESULTS: We examined in-hospital events among 24 908 subject encounters using propensity score 1:1 matching for ICD lead abandonment or explantation in the National Cardiovascular Data Registry (NCDR) ICD Registry (April 2010 to June 2014)...
July 2016: Circulation. Arrhythmia and Electrophysiology
Claude Daubert, Nathalie Behar, Raphaël P Martins, Philippe Mabo, Christophe Leclercq
Over two decades after the introduction of cardiac resynchronization therapy (CRT) into clinical practice, ∼30% of candidates continue to fail to respond to this highly effective treatment of drug-refractory heart failure (HF). Since the causes of this non-response (NR) are multifactorial, it will require multidisciplinary efforts to overcome. Progress has, thus far, been slowed by several factors, ranging from a lack of consensus regarding the definition of NR and technological limitations to the delivery of therapy...
July 1, 2016: European Heart Journal
Diane M Daubert, Joanna L Kelley, Yuriy G Udod, Carolina Habor, Chris G Kleist, Ilona K Furman, Igor N Tikonov, Willie J Swanson, Frank A Roberts
The tooth enamel development gene, enamelin (ENAM), showed evidence of positive selection during a genome-wide scan of human and primate DNA for signs of adaptive evolution. The current study examined the hypothesis that a single-nucleotide polymorphism (SNP) C14625T (rs7671281) in the ENAM gene identified in the genome-wide scan is associated with a change in enamel phenotype. African Americans were selected as the target population, as they have been reported to have a target SNP frequency of approximately 50%, whereas non-Africans are predicted to have a 96% SNP frequency...
2016: International Journal of Oral Science
Ulrika Ljung Faxén, Camilla Hage, Lina Benson, Stanislava Zabarovskaja, Anna Andreasson, Erwan Donal, Jean-Claude Daubert, Cecilia Linde, Kerstin Brismar, Lars H Lund
BACKGROUND: Anabolic drive is impaired in heart failure with reduced ejection fraction (HFrEF) but insufficiently studied in HF with preserved EF (HFpEF). Insulin-like growth factor 1 (IGF-1) mediates growth hormone effects and IGF binding protein 1 (IGFBP-1) regulates IGF-1 activity. We tested the hypothesis that HFpEF and HFrEF are similar with regard to IGF-1 and IGFBP-1. METHODS AND RESULTS: In patients with HFpEF (n=79), HFrEF (n=85), and controls (n=136), we analysed serum IGF-1and IGFBP-1 concentrations, correlations, and associations with outcome...
June 17, 2016: Journal of Cardiac Failure
Jacob P Kelly, James P Daubert
No abstract text is available yet for this article.
June 2016: JACC. Heart Failure
Raphael P Martins, Vincent Galand, Nathalie Behar, Philippe Mabo, Jean-Claude Daubert, Christophe Leclercq
No abstract text is available yet for this article.
August 2016: Pacing and Clinical Electrophysiology: PACE
Björn Wieslander, Zak Loring, Wojciech Zareba, Scott McNitt, Galen S Wagner, James P Daubert, David G Strauss
No abstract text is available yet for this article.
July 2016: Journal of Electrocardiology
Michael Nirenberg
This article is an introduction to the United States Supreme Court's standard of admissibility of forensic evidence and testimony at trial, known as the Daubert standard, with emphasis on how this standard applies to the field of forensic podiatry. The author, a forensic podiatrist, provided law enforcement with evidence tying a bloody sock-clad footprint found at the scene of a homicide to the suspect. In 2014, the author testified at a pretrial hearing, known as "a Daubert hearing," to address the admissibility of this evidence in court...
May 2016: Journal of Forensic Sciences
Neha J Pagidipati, Kshipra Hemal, Adrian Coles, Daniel B Mark, Rowena J Dolor, Patricia A Pellikka, Udo Hoffmann, Sheldon E Litwin, James Udelson, Melissa A Daubert, Svati H Shah, Beth Martinez, Kerry L Lee, Pamela S Douglas
BACKGROUND: Although risk stratification is an important goal of cardiac noninvasive tests (NITs), few contemporary data exist on the prognostic value of different NITs according to patient sex. OBJECTIVES: The goal of this study was to compare the results and prognostic information derived from anatomic versus stress testing in stable men and women with suspected coronary artery disease. METHODS: In 8,966 patients tested at randomization (4,500 to computed tomography angiography [CTA], 52% female; 4,466 to stress testing, 53% female), we assessed the relationship between sex and NIT results and between sex and a composite of death, myocardial infarction, or unstable angina hospitalization...
June 7, 2016: Journal of the American College of Cardiology
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