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https://www.readbyqxmd.com/read/27886920/why-we-have-to-use-cardiac-resynchronization-therapy-pacemaker-more
#1
REVIEW
Jean-Claude Daubert, Raphaël Martins, Christophe Leclercq
Both cardiac resynchronization therapy with a pacemaker (CRT-P) and with a biventricular implantable cardioverter-defibrillator (CRT-D) are electrical treatment modalities validated for the management of chronic heart failure. There is no strong scientific evidence that a CRT-D must be offered to all candidates. Common sense should limit the prescription of these costly and complicated devices. The choice of CRT-P is currently acceptable. A direction to explore could be to downgrade from CRT-D to CRT-P at the time of battery depletion in patients with large reverse remodeling and no ventricular tachycardia and ventricular fibrillation detected...
January 2017: Heart Failure Clinics
https://www.readbyqxmd.com/read/27886919/why-the-authors-use-cardiac-resynchronization-therapy-with-defibrillators
#2
REVIEW
Edward Sze, James P Daubert
Cardiac resynchronization therapy (CRT) improves left ventricular function, especially in patients with left bundle branch block or those receiving chronic right ventricular pacing. CRT is typically accomplished by placing a right ventricular endocardial pacing lead and a left ventricular pacing lead via the coronary sinus to a coronary vein overlying the lateral or posterolateral left ventricle. CRT can be combined with an implantable defibrillator or with a pacemaker. Limited data are available to compare these two versions of CRT head to head...
January 2017: Heart Failure Clinics
https://www.readbyqxmd.com/read/27886615/hfpef-and-hfref-exhibit-different-phenotypes-as-assessed-by-leptin-and-adiponectin
#3
Ulrika Ljung Faxén, Camilla Hage, Anna Andreasson, Erwan Donal, Jean-Claude Daubert, Cecilia Linde, Kerstin Brismar, Lars H Lund
BACKGROUND: Heart failure with reduced ejection fraction (HFrEF) exhibits a "reverse metabolic profile". Whether this profile exists in HF with preserved ejection fraction (HFpEF) is unknown. We tested the hypothesis that HFpEF and HFrEF are similar regarding concentrations of and prognostic impact of leptin and adiponectin. METHODS: In patients with HFpEF(n=79), HFrEF(n=84), and controls(n=71), we analyzed serum leptin and adiponectin concentrations, their correlations, and associations with outcome...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27858551/increased-levels-of-dissolved-titanium-are-associated-with-peri-implantitis-a-case-control-study
#4
Luciana M Safioti, Georgios A Kotsakis, Alex E Pozhitkov, Whasun O Chung, Diane M Daubert
BACKGROUND: Peri-implantitis represents a disruption of the biocompatible interface between the titanium (Ti) dioxide layer of the implant surface and the peri-implant tissues. Increasing preclinical data suggest that the peri-implantitis microbiota not only triggers an inflammatory immune response but also causes electrochemical alterations of the Ti surfaces, i.e. corrosion, that aggravate this inflammatory response. Thus, we hypothesized that there is an association between the dissolution of titanium from dental implants, which suggests corrosion, and peri-implantitis in humans...
November 18, 2016: Journal of Periodontology
https://www.readbyqxmd.com/read/27810081/left-bundle-branch-block-is-it-unsafe-at-any-speed
#5
EDITORIAL
Edward Sze, James P Daubert
No abstract text is available yet for this article.
November 2016: JACC. Heart Failure
https://www.readbyqxmd.com/read/27788392/changes-in-natriuretic-peptides-after-acute-hospital-presentation-for-heart-failure-with-preserved-ejection-fraction-a-feasible-surrogate-trial-endpoint-a-report-from-the-prospective-karen-study
#6
Gianluigi Savarese, Erwan Donal, Camilla Hage, Emmanuel Oger, Hans Persson, Jean-Claude Daubert, Cecilia Linde, Lars H Lund
BACKGROUND: In acute decompensated heart failure (ADHF) with preserved ejection fraction (HFpEF) there are no surrogate endpoints for early phase trials. The aim of the current study was to evaluate whether a reduction in natriuretic peptides (NP) between acute hospital presentation to stable follow-up is associated with improved mortality and morbidity. METHODS: Patients presenting acutely to the hospital for ADHF with HFpEF enrolled in the Karolinska Rennes (KaRen) study and reporting N-terminal pro-B-type NP or B-type NP assessment at baseline hospital presentation and at 4-8weeks follow-up were prospectively studied...
October 17, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27778339/permanent-his-bundle-pacing-an-adolescent-with-promise
#7
EDITORIAL
James P Daubert
No abstract text is available yet for this article.
October 24, 2016: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/27761170/erratum-to-2015-hrs-ehra-aphrs-solaece-expert-consensus-statement-on-optimal-implantable-cardioverter-de%C3%AF-brillator-programming-and-testing-journal-of-arrhythmia-32-1-2016-1-28
#8
Bruce L Wilkoff, Laurent Fauchier, Martin K Stiles, Carlos A Morillo, Sana M Al-Khatib, Jesœs Almendral, Luis Aguinaga, Ronald D Berger, Alejandro Cuesta, James P Daubert, Sergio Dubner, Kenneth A Ellenbogen, N A Mark Estes, Guilherme Fenelon, Fermin C Garcia, Maurizio Gasparini, David E Haines, Jeff S Healey, Jodie L Hurtwitz, Roberto Keegan, Christof Kolb, Karl-Heinz Kuck, Germanas Marinskis, Martino Martinelli, Mark McGuire, Luis G Molina, Ken Okumura, Alessandro Proclemer, Andrea M Russo, Jagmeet P Singh, Charles D Swerdlow, Wee Siong Teo, William Uribe, Sami Viskin, Chun-Chieh Wang, Shu Zhang
[This corrects the article DOI: 10.1016/j.joa.2015.12.001.].
October 2016: Journal of Arrhythmia
https://www.readbyqxmd.com/read/27760795/association-between-a-prolonged-pr-interval-and-outcomes-of-cardiac-resynchronization-therapy-a-report-from-the-national-cardiovascular-data-registry
#9
Daniel J Friedman, Haikun Bao, Erica S Spatz, Jeptha P Curtis, James P Daubert, Sana M Al-Khatib
BACKGROUND: A prolonged PR interval is common among cardiac resynchronization therapy (CRT) candidates; however, the association between PR interval and outcomes is unclear, and the data are conflicting. METHODS: We conducted inverse probability weighted analyses of 26 451 CRT-eligible (ejection fraction ≤35, QRS ≥120 ms) patients from the National Cardiovascular Data Registry ICD Registry to assess the association between a prolonged PR interval (≥230 ms), receipt of CRT with defibrillator (CRT-D) versus implantable cardioverter defibrillator (ICD), and outcomes...
November 22, 2016: Circulation
https://www.readbyqxmd.com/read/27756767/ranolazine-reduces-atrial-fibrillatory-wave-frequency
#10
Eric W Black-Maier, Sean D Pokorney, Adam S Barnett, Peter Liu, Peter Shrader, Jason Ng, Jeffrey J Goldberger, Wojiech Zareba, James P Daubert, Augustus O Grant, Jonathan P Piccini
AIMS: Antiarrhythmic medications for the treatment of atrial fibrillation (AF) have limited efficacy and rare but potentially life-threatening side effects. Ranolazine is an antianginal agent that may have antiarrhythmic activity in AF. METHODS AND RESULTS: Using the Duke Enterprise Data Unified Content Explorer database, we analysed a cohort of AF patients on ranolazine. Patients served as their own historic control. Electrocardiograms (ECGs) were analysed before and after ranolazine initiation to determine the effect of ranolazine on dominant frequency (DF), f-wave amplitude, and organizational index (OI)...
October 17, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/27755013/effectiveness-of-extracorporeal-life-support-for-patients-with-cardiogenic-shock-due-to-intractable-arrhythmic-storm
#11
Solène Le Pennec-Prigent, Erwan Flecher, Vincent Auffret, Guillaume Leurent, Jean-Claude Daubert, Christophe Leclercq, Philippe Mabo, Jean-Philippe Verhoye, Raphael P Martins
OBJECTIVES: Extracorporeal life support is used for patients with severe heart failure as a bridge to heart transplantation or recovery. We aimed at analyzing the efficacy and safety of extracorporeal life support to treat refractory arrhythmic storm responsible for cardiogenic shock in patients resistant to antiarrhythmic drugs. DESIGN: Retrospective study. SETTING: University Hospital of Rennes, France. PATIENTS: Patients with refractory arrhythmic storm admitted between January 2005 and March 2015...
October 14, 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27720558/critical-review-of-current-approaches-for-echocardiographic-reproducibility-and-reliability-assessment-in-clinical-research
#12
Anna Lisa Crowley, Eric Yow, Huiman X Barnhart, Melissa A Daubert, Robert Bigelow, Daniel C Sullivan, Michael Pencina, Pamela S Douglas
BACKGROUND: There is no broadly accepted standard method for assessing the quality of echocardiographic measurements in clinical research reports, despite the recognized importance of this information in assessing the quality of study results. METHODS: Twenty unique clinical studies were identified reporting echocardiographic data quality for determinations of left ventricular (LV) volumes (n = 13), ejection fraction (n = 12), mass (n = 9), outflow tract diameter (n = 3), and mitral Doppler peak early velocity (n = 4)...
December 2016: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/27696593/sex-differences-in-inappropriate-icd-device-therapies-madit-ii-and-madit-crt
#13
Christine M Tompkins, Scott McNitt, Bronislava Polonsky, James P Daubert, Paul J Wang, Arthur J Moss, Wojciech Zareba, Valentina Kutyifa
INTRODUCTION: Approximately 10-20% of ICD recipients receive inappropriate device therapies. The purpose of this study was to compare the frequency of inappropriate therapies (IT) between men and women enrolled in MADIT II and MADIT-CRT, and assess for potential adverse outcomes. METHODS: The electrograms for each ICD or CRT-D therapy, defined as either ATP or shock, were reviewed by adjudication committees for both studies. ICD therapy was considered inappropriate if it was delivered for reasons other than VT/VF...
October 2, 2016: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/27692658/localization-of-gaps-during-redo-ablations-of-paroxysmal-atrial-fibrillation-preferential-patterns-depending-on-the-choice-of-cryoballoon-ablation-or-radiofrequency-ablation-for-the-initial-procedure
#14
Vincent Galand, Dominique Pavin, Nathalie Behar, Vincent Auffret, Damien Fénéon, Albin Behaghel, Jean-Claude Daubert, Philippe Mabo, Raphaël P Martins
BACKGROUND: Pulmonary vein (PV) isolation, using cryoballoon or radiofrequency ablation, is the cornerstone therapy for symptomatic paroxysmal atrial fibrillation (AF) refractory to antiarrhythmic drugs. One-third of the patients have recurrences, mainly due to PV reconnections. AIMS: To describe the different locations of reconnection sites in patients who had previously undergone radiofrequency or cryoballoon ablation, and to compare the characteristics of the redo procedures in both instances...
November 2016: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/27670631/fragmentation-and-de-fragmenting-how-to-ablate-in-the-age-of-connectivity
#15
Stephen Gaeta, James P Daubert
No abstract text is available yet for this article.
September 23, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27634722/don-t-ask-a-neuroscientist-about-phases-of-the-moon
#16
Katherine Shats, Timothy Brindley, James Giordano
Ongoing developments in neuroscientific techniques and technologies-such as neuroimaging-offer potential for greater insight into human behavior and have fostered temptation to use these approaches in legal contexts. Neuroscientists are increasingly called on to provide expert testimony, interpret brain images, and thereby inform judges and juries who are tasked with determining the guilt or innocence of an individual. In this essay, we draw attention to the actual capabilities and limitations of currently available assessment neurotechnologies and examine whether neuroscientific evidence presents unique challenges to existing frameworks of evidence law...
October 2016: Cambridge Quarterly of Healthcare Ethics: CQ: the International Journal of Healthcare Ethics Committees
https://www.readbyqxmd.com/read/27544745/bilateral-bundle-branch-block-an-old-concept-revisited-in-the-light-of-cardiac-resynchronization-therapy
#17
Claude Daubert, Philippe Mabo
No abstract text is available yet for this article.
August 17, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27502864/defining-nonvalvular-atrial-fibrillation-a-quest-for-clarification
#18
REVIEW
Raphaël P Martins, Vincent Galand, Edouard Colette, Nathalie Behar, Dominique Pavin, Christophe Leclercq, Jean-Claude Daubert, Philippe Mabo
Non-vitamin K oral anticoagulants (NOACs) are currently recommended for patients with nonvalvular atrial fibrillation since the publication of the 4 major pivotal trials evaluating the efficacy and safety of factor IIa and factor Xa inhibitors. The definition of nonvalvular atrial fibrillation is unclear, varying from one trial to another and even between North American and European guidelines, which is a source of uncertainties in clinical practice. However, many patients with atrial fibrillation present signs of valvular involvement, and clarification of this term is needed to not deny NOACs to patients based on the wrong perception that they may have valvular atrial fibrillation...
August 2016: American Heart Journal
https://www.readbyqxmd.com/read/27406605/outcomes-1-year-after-implantable-cardioverter-defibrillator-lead-abandonment-versus-explantation-for-unused-or-malfunctioning-leads-a-report-from-the-national-cardiovascular-data-registry
#19
Emily P Zeitler, Yongfei Wang, Kumar Dharmarajan, Kevin J Anstrom, Eric D Peterson, James P Daubert, Jeptha P Curtis, Sana M Al-Khatib
BACKGROUND: Patients with an unused or malfunctioning implantable cardioverter-defibrillator (ICD) lead may have the lead either abandoned or explanted; yet there are limited data on the comparative acute and longer-term safety of these 2 approaches. METHODS AND RESULTS: We examined in-hospital events among 24 908 subject encounters using propensity score 1:1 matching for ICD lead abandonment or explantation in the National Cardiovascular Data Registry (NCDR) ICD Registry (April 2010 to June 2014)...
July 2016: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/27371720/avoiding-non-responders-to-cardiac-resynchronization-therapy-a-practical-guide
#20
Claude Daubert, Nathalie Behar, Raphaël P Martins, Philippe Mabo, Christophe Leclercq
Over two decades after the introduction of cardiac resynchronization therapy (CRT) into clinical practice, ∼30% of candidates continue to fail to respond to this highly effective treatment of drug-refractory heart failure (HF). Since the causes of this non-response (NR) are multifactorial, it will require multidisciplinary efforts to overcome. Progress has, thus far, been slowed by several factors, ranging from a lack of consensus regarding the definition of NR and technological limitations to the delivery of therapy...
July 1, 2016: European Heart Journal
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