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https://www.readbyqxmd.com/read/29222043/catheter-ablation-of-atrial-fibrillation-in-patients-with-heart-failure-and-preserved-ejection-fraction
#1
Eric Black-Maier, Xinru Ren, Benjamin A Steinberg, Cynthia L Green, Adam S Barnett, Normita Sta Rosa, Sana M Al-Khatib, Brett D Atwater, James P Daubert, Camille Frazier-Mills, Augustus O Grant, Donald D Hegland, Kevin P Jackson, Larry R Jackson, Jason I Koontz, Robert K Lewis, Albert Y Sun, Kevin L Thomas, Tristam D Bahnson, Jonathan P Piccini
BACKGROUND: Few studies have examined outcomes of catheter ablation for atrial fibrillation (AF) in patients with heart failure with preserved ejection fraction (HFpEF). OBJECTIVE: Compare outcomes of AF ablation in patients with HFpEF versus HF with reduced ejection fraction (HFrEF). METHODS: We performed a retrospective study of 230 patients with HF who underwent AF ablation, including 97 (42.2%) with HFrEF and 133 (57.8%) with HFpEF. Outcomes included adverse events, symptoms (Mayo AF Symptom Inventory [MAFSI]), New York Heart Association (NYHA) functional class, and freedom from recurrent atrial arrhythmia at 12-months...
December 5, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29217757/novel-mitochondria-targeting-peptide-in-heart-failure-treatment-a-randomized-placebo-controlled-trial-of-elamipretide
#2
Melissa A Daubert, Eric Yow, Gary Dunn, Sotir Marchev, Huiman Barnhart, Pamela S Douglas, Christopher O'Connor, Sidney Goldstein, James E Udelson, Hani N Sabbah
BACKGROUND: Mitochondrial dysfunction and energy depletion in the failing heart are innovative therapeutic targets in heart failure management. Elamipretide is a novel tetrapeptide that increases mitochondrial energy; however, its safety, tolerability, and therapeutic effect on cardiac structure and function have not been studied in heart failure with reduced ejection fraction. METHODS AND RESULTS: In this double-blind, placebo-controlled, ascending-dose trial, patients with heart failure with reduced ejection fraction (ejection fraction, ≤35%) were randomized to either a single 4-hour infusion of elamipretide (cohort 1 [n=8], 0...
December 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29133182/a-novel-method-for-localization-and-ablation-of-conduction-gaps-after-wide-antral-circumferential-ablation-of-pulmonary-veins
#3
Raoul Bacquelin, Raphaël P Martins, Nathalie Behar, Vincent Galand, Baptiste Polin, Jonathan Lacaze, Frédéric Sebag, Christophe Leclercq, Jean-Claude Daubert, Philippe Mabo, Dominique Pavin
BACKGROUND: Atrial fibrillation ablation is often performed by achieving pulmonary vein isolation using the "wide antral circumferential ablation" (WACA) technique, but many pulmonary veins remain connected because of conduction gaps in the ablation line. AIM: To analyse the efficacy of a novel technique based on pacing manoeuvres to detect gaps in an initial WACA lesion. METHODS: Patients referred for radiofrequency atrial fibrillation ablation were enrolled prospectively...
November 10, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/29106577/pacing-for-hypertrophic-obstructive-cardiomyopathy-an-update-and-future-directions
#4
Claude Daubert, Fredrik Gadler, Philippe Mabo, Cecilia Linde
In hypertrophic cardiomyopathy (HCM) patients with symptoms caused by left ventricular outflow tract obstruction (LVOTO), treatment options include negative inotropic drugs, myectomy, septal alcohol ablation and AV sequential pacing with or without an implantable cardioverter defibrillator (ICD). Pacing is rarely used in spite of its relative simplicity and promising results. In this review the current evidence of AV sequential pacing from observational, randomised studies and long and very long-term follow-up studies is given and put in the context of present guidelines recommendations...
June 30, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29052236/heart-failure-severity-inappropriate-icd-therapy-and-novel-icd-programming-a-madit-rit-sub-study
#5
Usama A Daimee, Katherine Vermilye, Spencer Rosero, Claudio D Schuger, James P Daubert, Wojciech Zareba, Scott McNitt, Bronislava Polonsky, Arthur J Moss, Valentina Kutyifa
BACKGROUND: The effects of heart failure (HF) severity on risk of inappropriate implantable cardioverter-defibrillator (ICD) therapy have not been thoroughly investigated. We aimed to study the association between HF severity and inappropriate ICD therapy in MADIT-RIT. METHODS: MADIT-RIT randomized 1500 patients to three ICD programming arms: conventional (Arm A), high-rate cut-off (Arm B: ≥200 bpm), and delayed therapy (Arm C: 60-second delay for ≥170 bpm)...
October 20, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29038172/precision-medicine-for-cardiac-resynchronization-predicting-quality-of-life-benefits-for-individual-patients-an-analysis-from-5-clinical-trials
#6
Michael E Nassif, Yuanyuan Tang, John G Cleland, William T Abraham, Cecilia Linde, Michael R Gold, James B Young, J Claude Daubert, Lou Sherfesee, Dan Schaber, Anthony S L Tang, Philip G Jones, Suzanne V Arnold, John A Spertus
BACKGROUND: Clinical trials have established the average benefit of cardiac resynchronization therapy (CRT), but estimating benefit for individual patients remains difficult because of the heterogeneity in treatment response. Accordingly, we created a multivariable model to predict changes in quality of life (QoL) with and without CRT. METHODS AND RESULTS: Patient-level data from 5 randomized trials comparing CRT with no CRT were used to create a prediction model of change in QoL at 3 months using a partial proportional odds model for no change, small, moderate, and large improvement, or deterioration of any magnitude...
October 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29016785/obstructive-sleep-apnea-is-associated-with-increased-rotor-burden-in-patients-undergoing-focal-impulse-and-rotor-modification-guided-atrial-fibrillation-ablation
#7
Daniel J Friedman, Peter Liu, Adam S Barnett, Kristen Bova Campbell, Kevin P Jackson, Tristram D Bahnson, James P Daubert, Jonathan P Piccini
Aims: To assess whether obstructive sleep apnea (OSA) was associated with increased rotor burden among atrial fibrillation (AF) patients. Methods and results: We studied 33 consecutive patients who were scheduled for focal impulse and rotor modulation (FIRM) ablation at our institution to describe the mapping, ablation, and outcomes, among patients with and without OSA. Patients underwent biatrial FIRM mapping in AF with ablation of stable rotors in addition to conventional ablation lesion sets...
August 9, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29016748/the-second-generation-cryoballoon-has-improved-durable-isolation-of-left-but-not-right-pulmonary-veins-new-insights-from-a-multicentre-study
#8
Raphaël P Martins, Vincent Galand, Olivier Cesari, Antoine Milhem, Nathalie Behar, Vincent Auffret, Jean-Claude Daubert, Philippe Mabo, Dominique Pavin
Aims: Pulmonary vein isolation (PVI) using second-generation cryoballoon (CB2) is associated with improved outcomes compared with first generation (CB1). We aimed at investigating the characteristics of left and right PV reconnections after CB1 and CB2 ablations in patients with clinical recurrences requiring redo ablation. Methods and results: From 2010 to 2016, 776 patients underwent 28-mm cryoballoon PVI for symptomatic paroxysmal atrial fibrillation (AF) in 3 centres, 279 with CB1 and 497 with CB2...
July 12, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28985447/restoration-contour-is-a-risk-indicator-for-peri-implantitis-a-cross-sectional-radiographic-analysis
#9
Michitsuna Katafuchi, Bradley F Weinstein, Brian G Leroux, Yen-Wei Chen, Diane M Daubert
AIM: The purpose of this study was to determine if restoration emergence angle was associated with peri-implantitis. MATERIALS AND METHODS: A data set consisting of 96 patients with 225 implants (mean follow-up: 10.9 years) was utilized. Implants were divided into bone level and tissue level groups and radiographs were analyzed to determine the restoration emergence angles, as well as restoration profiles (convex or concave). Peri-implantitis was diagnosed based on probing depth and radiographic bone loss...
October 6, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28964778/predictors-and-prognostic-impact-of-new-left-bundle-branch-block-after-surgical-aortic-valve-replacement
#10
Moukda Khounlaboud, Erwan Flécher, Maxime Fournet, Hervé Le Breton, Erwan Donal, Christophe Leclercq, Philippe Mabo, Alain Leguerrier, Claude Daubert
BACKGROUND: Left bundle branch block (LBBB) induces mechanical dyssynchrony that may lead to left ventricular systolic dysfunction. AIMS: To evaluate the incidence, predictors and clinical impact of new LBBB in patients undergoing surgical aortic valve replacement (SAVR). METHODS: After exclusion of patients with pre-existing LBBB, a previous pacemaker or a paced rhythm at hospital discharge, 547 consecutive patients undergoing SAVR were included...
December 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/28958452/comparison-of-incidence-of-left-ventricular-systolic-dysfunction-among-patients-with-left-bundle-branch-block-versus-those-with-normal-qrs-duration
#11
Edward Sze, Allison Dunning, Zak Loring, Brett D Atwater, Karen Chiswell, James P Daubert, Joseph A Kisslo, Daniel B Mark, Eric J Velazquez, Zainab Samad
We compared the incidence of left ventricular systolic dysfunction (LVSD) among patients with left bundle branch block (LBBB) to a matched cohort of patients with a narrow QRS duration <120 ms (NQRS). We hypothesized patients with preserved ejection fraction (EF) ≥50% and LBBB would have higher incidence of LVSD compared with a matched population of NQRS patients. Patients with LBBB on electrocardiogram within 30 days of a baseline echocardiogram with EF ≥50%, who had at least 1 follow-up echocardiogram ≥6 months later, were matched 1:1 on risk factors for cardiomyopathy to patients with NQRS...
August 30, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28944317/comparison-of-regional-vs-general-anesthesia-for-surgical-repair-of-open-globe-injuries-at-a-university-referral-center
#12
Andrew J McClellan, Jacquelyn J Daubert, Nidhi Relhan, Kimberly D Tran, Harry W Flynn, Steven Gayer
PURPOSE: This study compares the clinical features and physician selection of either Regional Anesthesia (peribulbar or retrobulbar block) with Monitored Anesthesia Care (RA-MAC) or General Anesthesia (GA) for open globe injury repair. DESIGN: A non-randomized, comparative, retrospective case series at a University Referral Center. PARTICIPANTS: All adult repairable open globe injuries receiving primary repair between January 1st, 2004 and December 31st, 2014 (11 years)...
May 2017: Ophthalmology Retina
https://www.readbyqxmd.com/read/28940909/postimplantation-ventricular-ectopic-burden-and-clinical-outcomes-in-cardiac-resynchronization-therapy-defibrillator-patients-a-madit-crt-substudy
#13
Anne-Christine Ruwald, Mehmet K Aktas, Martin H Ruwald, Valentina Kutyifa, Scott McNitt, Christian Jons, Suneet Mittal, Jonathan S Steinberg, James P Daubert, Arthur J Moss, Wojciech Zareba
BACKGROUND: Frequent ventricular ectopy on preimplantation Holter has been associated with attenuated benefit from cardiac resynchronization therapy (CRT). However, it is unclear whether ectopic burden measured post-CRT implantation can be utilized to evaluate long-term prognosis. We aimed to describe the association between post-CRT implantation ectopic burden and subsequent risk of clinical outcomes. METHODS: At the 12-month follow-up visit, 24-hour Holter recordings were performed in 698 CRT-D patients from the MADIT-CRT study...
September 20, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28874289/clinical-predictors-of-challenging-atrioventricular-node-ablation-procedure-for-rate-control-in-patients-with-atrial-fibrillation
#14
Baptiste Polin, Nathalie Behar, Vincent Galand, Vincent Auffret, Albin Behaghel, Dominique Pavin, Jean-Claude Daubert, Philippe Mabo, Christophe Leclercq, Raphael P Martins
INTRODUCTION: Atrioventricular node (AVN) ablation is usually a simple procedure but may sometimes be challenging. We aimed at identifying pre-procedural clinical predictors of challenging AVN ablation. METHODS: Patients referred for AVN ablation from 2009 to 2015 were retrospectively included. Baseline clinical data, procedural variables and outcomes of AVN ablation were collected. A "challenging procedure" was defined 1) total radiofrequency delivery to get persistent AVN block≥400s, 2) need for left-sided arterial approach or 3) failure to obtain AVN ablation...
October 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28829224/the-mmpi-2-mmpi-2-rf-symptom-validity-scale-fbs-fbs-r-is-not-a-measure-of-litigation-response-syndrome-commentary-on-nichols-and-gass-2015
#15
Glenn J Larrabee, Kevin J Bianchini, Kyle B Boone, Martin L Rohling
OBJECTIVES: To address (1) Whether there is empirical evidence for the contention of Nichols and Gass that the MMPI-2/MMPI-2-RF FBS/FBS-r Symptom Validity Scale is a measure of Litigation Response Syndrome (LRS), representing a credible set of responses and reactions of claimants to the experience of being in litigation, rather than a measure of non-credible symptom report, as the scale is typically used; and (2) to address their stated concerns about the validity of FBS/FBS-r meta-analytic results, and the risk of false positive elevations in persons with bona-fide medical conditions...
August 22, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28691774/bite-mark-analysis-in-foodstuffs-and-inanimate-objects-and-the-underlying-proofs-for-validity-and-judicial-acceptance
#16
Fernando Rivera-Mendoza, Stella Martín-de-Las-Heras, Pablo Navarro-Cáceres, Gabriel M Fonseca
Even though one of the first bite mark cases was Doyle v. State in 1954 (a bitten cheese case), the research has focused on bite marks inflicted in human skin. As published Papers, Case Reports, or Technical Notes can constitute precedents which are relied upon in making the legal arguments and a considerable amount of case law exists in this area, we present a systematic review on bite mark analysis in foodstuffs and inanimate objects and their underlying proofs for validity and judicial acceptance according to Daubert rulings...
July 10, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28625384/effects-of-implantable-cardioverter-defibrillator-shock-and-antitachycardia-pacing-on-anxiety-and-quality-of-life-a-madit-rit-substudy
#17
RANDOMIZED CONTROLLED TRIAL
Alessandro Paoletti Perini, Valentina Kutyifa, Peter Veazie, James P Daubert, Claudio Schuger, Wojciech Zareba, Scott McNitt, Spencer Rosero, Christine Tompkins, Luigi Padeletti, Arthur J Moss
Effects of implantable cardioverter/defibrillator (ICD) shocks and antitachycardia pacing (ATP) on anxiety and quality of life (QoL) in ICD patients are poorly understood. METHODS: We evaluated changes in QoL from baseline to 9-month follow-up using the EQ-5D questionnaire in patients enrolled in the Multicenter Automatic Defibrillator Implantation Trial-Reduce Inappropriate Therapy (MADIT-RIT) (n=1,268). We assessed anxiety levels using the Florida Shock Anxiety Scale (1-10 score) in patients with appropriate or inappropriate shocks or ATP compared to those with no ICD therapy during the first 9 months postimplant...
July 2017: American Heart Journal
https://www.readbyqxmd.com/read/28625372/multicenter-automatic-defibrillator-implantation-trial-subcutaneous-implantable-cardioverter-defibrillator-madit-s-icd-design-and-clinical-protocol
#18
RANDOMIZED CONTROLLED TRIAL
Valentina Kutyifa, Christopher Beck, Mary W Brown, David Cannom, James Daubert, Mark Estes, Henry Greenberg, Ilan Goldenberg, Stephen Hammes, David Huang, Helmut Klein, Reinoud Knops, Mikhail Kosiborod, Jeanne Poole, Claudio Schuger, Jagmeet P Singh, Scott Solomon, David Wilber, Wojciech Zareba, Arthur J Moss
Patients with diabetes mellitus, prior myocardial infarction, older age, and a relatively preserved left ventricular ejection fraction remain at risk for sudden cardiac death that is potentially amenable by the subcutaneous implantable cardioverter defibrillator with a good risk-benefit profile. The launched MADIT S-ICD study is designed to test the hypothesis that post-myocardial infarction diabetes patients with relatively preserved ejection fraction of 36%-50% will have a survival benefit from a subcutaneous implantable cardioverter defibrillator...
July 2017: American Heart Journal
https://www.readbyqxmd.com/read/28623910/pilot-study-using-3d-longitudinal-strain-computation-in-a-multi-parametric-approach-for-best-selecting-responders-to-cardiac-resynchronization-therapy
#19
Maxime Fournet, Anne Bernard, Sylvestre Marechaux, Elena Galli, Raphael Martins, Philippe Mabo, J Claude Daubert, Christophe Leclercq, Alfredo Hernandez, Erwan Donal
BACKGROUND: Almost all attempts to improve patient selection for cardiac resynchronization therapy (CRT) using echo-derived indices have failed so far. We sought to assess: the performance of homemade software for the automatic quantification of integral 3D regional longitudinal strain curves exploring left ventricular (LV) mechanics and the potential value of this tool to predict CRT response. METHODS: Forty-eight heart failure patients in sinus rhythm, referred for CRT-implantation (mean age: 65 years; LV-ejection fraction: 26%; QRS-duration: 160 milliseconds) were prospectively explored...
June 17, 2017: Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/28596994/recurrent-post-ablation-paroxysmal-atrial-fibrillation-shares-substrates-with-persistent-atrial-fibrillation-an-11-center-study
#20
Junaid A B Zaman, Tina Baykaner, Paul Clopton, Vijay Swarup, Robert C Kowal, James P Daubert, John D Day, John Hummel, Amir A Schricker, David E Krummen, Moussa Mansour, Gery F Tomassoni, Kevin R Wheelan, Mohan Vishwanathan, Shirley Park, Paul J Wang, Sanjiv M Narayan, John M Miller
INTRODUCTION: The role of atrial fibrillation (AF) substrates is unclear in patients with paroxysmal AF (PAF) that recurs after pulmonary vein isolation (PVI). We hypothesized that patients with recurrent post-ablation (redo) PAF despite PVI have electrical substrates marked by rotors and focal sources, and structural substrates that resemble persistent AF more than patients with (de novo) PAF at first ablation. METHODS: In 175 patients at 11 centers, we compared AF substrates in both atria using 64 pole-basket catheters and phase mapping, and indices of anatomical remodeling between patients with de novo or redo PAF and first ablation for persistent AF...
April 2017: JACC. Clinical Electrophysiology
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