keyword
MENU ▼
Read by QxMD icon Read
search

cancer and mycoplasma

keyword
https://www.readbyqxmd.com/read/29670864/mechanism-of-apoptosis-induction-by-mycoplasmal-nuclease-mga_0676-in-chicken-embryo-fibroblasts
#1
Peng Li, Jian Xu, Hong-Mei Rao, Xia Li, Yun-Ke Zhang, Fei Jiang, Wen-Xue Wu
MGA_0676 has been characterized as a Mycoplasma gallisepticum nuclease that can induce apoptosis of chicken cells. However, the mechanism by which MGA_0676 induces apoptosis has remained unclear. In this study, we evaluated MGA_0676-induced apoptosis and internalization in immortalized chicken embryo fibroblasts (DF-1) and cancer cell lines. The internalization of MGA_0676 was proven through caveolin-mediated endocytosis by blocking the endocytosis with specific inhibitors or with siRNA. We identified the Thif domain of NEDD8-activating enzyme E1 regulatory subunit (NAE) in DF-1 as the target region interacting with the SNC domain of MGA_0676...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29664764/epstein-barr-virus-high-risk-human-papillomavirus-and-abnormal-cervical-cytology-in-a-prospective-cohort-of-african-female-sex-workers
#2
Jennifer E Cameron, Anne F Rositch, Nadja A Vielot, Nelly R Mugo, Jessie K L Kwatampora, Wairimu Waweru, Aubrey E Gilliland, Michael E Hagensee, Jennifer S Smith
BACKGROUND: High oncogenic-risk human papillomavirus (hrHPV) is necessary, although insufficient, to promote cervical cancer. Like HPV, Epstein-Barr virus (EBV) is a common pathogen with the capacity to promote epithelial neoplasms. We examined the association between cervical EBV, hrHPV, and cytology in female sex workers in Nairobi, Kenya. METHODS: Women (n=332) with known cervical cytology and hrHPV mRNA results were evaluated for cervical EBV DNA by conventional PCR...
April 17, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29580805/mycoplasma-infection-and-hypoxia-initiate-succinate-accumulation-and-release-in-the-vm-m3-cancer-cells
#3
Roberto E Flores, Ashley K Brown, Luke Taus, Julianna Khoury, Frank Glover, Kenjiro Kami, Rangaprasad Sarangarajan, Tony Walshe, Niven R Narain, Michael A Kiebish, Laura Shelton, Christos Chinopoulos, Thomas N Seyfried
Succinate is known to act as an inflammatory signal in classically activated macrophages through stabilization of HIF-1α leading to IL-1β production. Relevant to this, hypoxia is known to drive succinate accumulation and release into the extracellular milieu. The metabolic alterations associated with succinate release during inflammation and under hypoxia are poorly understood. Data are presented showing that Mycoplasma arginini infection of VM-M3 cancer cells enhances the Warburg effect associated with succinate production in mitochondria and eventual release into the extracellular milieu...
March 23, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29549429/integrated-morphologic-and-molecular-analysis-of-trichomonas-vaginalis-mycoplasma-hominis-and-human-papillomavirus-using-cytologic-smear-preparations
#4
I Nikas, A Hapfelmeier, M Mollenhauer, D Angermeier, M Bettstetter, R Götz, M Schmidmayr, V Seifert-Klauss, A Muckenhuber, U Schenck, Gregor Weirich
Pathogenic microbes may colonize the female genital tract via sexual transmission and cause health issues like inflammation or malignancy, summarized as sexually transmitted disease (STD). A major representative of such pathogens is Trichomonas vaginalis (T.v.), whose role in the etiology of cervical cancer remains elusive. Traditional morphologic screening of cervical smears is able to detect T.v., although its identification may be complicated by look-alikes such as degenerated granulocytes and basal cells...
March 17, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29520664/association-between-genital-mycoplasmas-infection-and-human-papillomavirus-infection-abnormal-cervical-cytopathology-and-cervical-cancer-a-systematic-review-and-meta-analysis
#5
REVIEW
Hui Ye, Tiange Song, Xi Zeng, Lin Li, Minmin Hou, Mingrong Xi
BACKGROUND: Some studies demonstrated that female genital mycoplasmas play important roles in human papillomavirus (HPV) infection, abnormal cervical cytopathology, and cervical cancer. However, those results remained inconclusive. We aimed to perform a systematic review and meta-analysis to investigate the association between female genital mycoplasmas and those disorders. METHODS: Computerized databases were comprehensively searched before 26 January 2017. Pooled odd radios (ORs) and correlative 95% confidence intervals (CIs) were adopted to evaluate the strength of association...
March 8, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29369931/identifying-acute-cervicitis-in-an-era-of-less-frequent-routine-gynecologic-examinations
#6
Margaret Allen
Acute inflammation of the uterine cervix can lead to serious problems such as pelvic inflammatory disease (PID), endometritis, and complications of pregnancy and childbirth. As intervals for routine gynecologic screening examinations lengthen, cervical infections, especially if asymptomatic, may be missed. Annual wellness examinations and other patient visits outside routine gynecologic cancer screening visits should include brief evaluation with sexual risk assessment and a gynecologic examination if indicated...
February 2018: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/29363409/decreasing-the-immunogenicity-of-arginine-deiminase-enzyme-via-structure-based-computational-analysis
#7
Mahboubeh Zarei, Navid Nezafat, Mohammad Reza Rahbar, Manica Negahdaripour, Soudabeh Sabetian, Mohammad Hossein Morowvat, Younes Ghasemi
The clinical applications of therapeutic enzymes are often limited due to their immunogenicity. B-cell epitope removal is an effective approach to solve this obstacle. The identification of hot spot epitopic residues is a critical step in the removal of protein B-cell epitope. Hereof, computational approaches are a suitable alternative to costly and labor-intensive experimental approaches. Arginine deiminase, a Mycoplasma arginine-catabolizing enzyme, is in the clinical trial for treating arginine auxotrophic cancers, especially hepatocellular carcinomas and melanomas through depleting plasma arginine and causing cell starvation...
February 7, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29285029/establishment-and-characterization-of-primary-cultures-from-iranian-oral-squamous-cell-carcinoma-patients-by-enzymatic-method-and-explant-culture
#8
Meysam Ganjibakhsh, Pouyan Aminishakib, Parvaneh Farzaneh, Abbas Karimi, Seyed Abolhassan Shahzadeh Fazeli, Moones Rajabi, Ahmad Nasimian, Fereshteh Baghai Naini, Hedieh Rahmati, Neda Sadat Gohari, Nazanin Mohebali, Masoumeh Asadi, Zahra Elyasi Gorji, Mehrnaz Izadpanah, Shiva Mohamadi Moghanjoghi, Sepideh Ashouri
Objectives: Oral Squamous Cell Carcinoma (OSCC) is the most frequent oral cancer worldwide. It is known as the eighth most common cancer in men and as the fifth most common cancer in women. Cytogenetic and biochemical studies in recent decades have emphasized the necessity of providing an appropriate tool for such researches. Cancer cell culture is a useful tool for investigations on biochemical, genetic, molecular and immunological characteristics of different cancers, including oral cancer...
July 2017: Journal of Dentistry of Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/28976984/mycoplasma-associated-multidrug-resistance-of-hepatocarcinoma-cells-requires-the-interaction-of-p37-and-annexin-a2
#9
Danyang Liu, Yang Hu, Ying Guo, Zhu Zhu, Bingzheng Lu, Xuelan Wang, Yijun Huang
Mycoplasma infection has been reported to be associated with cancer migration, invasion, epithelial-mesenchymal transition as well as the resistance to nucleoside analogues chemotherapeutic drugs. In this study, we found that the sensitivity of hepatocarcinoma cells to Cisplatin, Gemcitabine and Mitoxantrone was increased by mycoplasma elimination. Similar to the effect of anti-mycoplasma agent, interrupting the interaction between Mycoplasma hyorhinis membrane protein P37 and Annexin A2 of host cells using the N-terminal of ANXA2 polypeptide enhanced the sensitivity of HCC97L cells to Gemcitabine and Mitoxantrone...
2017: PloS One
https://www.readbyqxmd.com/read/28878274/development-of-oric-plasmids-for-use-in-mycoplasma-hyorhinis
#10
Hassan Z A Ishag, Qiyan Xiong, Maojun Liu, Zhixin Feng, Guoqing Shao
Mycoplasma hyorhinis (M. hyorhinis) is an opportunistic pig pathogen, belonging to the class Mollicutes. It causes polyserositis, arthritis and cancers in vitro, increasing attention of the researchers. Currently, there is no available genetic tool to manipulate its genome. This study describes a development of oriC-plasmids harboring either large (pGEMT-LoriC) or minimum (pGEMT-MoriC) origin of replication (oriC) of M. hyorhinis along with tetracycline resistance marker.These plasmids were successfully transformed into M...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28692662/potential-malignant-transformation-in-the-gastric-mucosa-of-immunodeficient-mice-with-persistent-mycoplasma-penetrans-infection
#11
Shuyan Cao, Dandan Shen, Yadong Wang, Linxi Li, Liping Zhou, Yuxue Wang
Mycoplasma infection has been reported in immunocompromised cancer patients; nevertheless, it is not clear if persistent Mycoplasma infection could facilitate the proliferation of cancer cells in immunocompromised organisms. The aim of this study was to examine the relationship between persistent Mycoplasma infection and malignant transformation in an immunodeficient host model. Immunodeficient mouse model was established using cyclophosphamide and mice gastric mucosal cells were infected with Mycoplasma penetrans (Mpe)...
2017: PloS One
https://www.readbyqxmd.com/read/28623321/dysbiosis-in-chronic-periodontitis-key-microbial-players-and-interactions-with-the-human-host
#12
Zhi-Luo Deng, Szymon P Szafrański, Michael Jarek, Sabin Bhuju, Irene Wagner-Döbler
Periodontitis is an extremely prevalent disease worldwide and is driven by complex dysbiotic microbiota. Here we analyzed the transcriptional activity of the periodontal pocket microbiota from all domains of life as well as the human host in health and chronic periodontitis. Bacteria showed strong enrichment of 18 KEGG functional modules in chronic periodontitis, including bacterial chemotaxis, flagellar assembly, type III secretion system, type III CRISPR-Cas system, and two component system proteins. Upregulation of these functions was driven by the red-complex pathogens and candidate pathogens, e...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28529540/the-potential-role-of-infectious-agents-and-pelvic-inflammatory-disease-in-ovarian-carcinogenesis
#13
REVIEW
Kasper Ingerslev, Estrid Hogdall, Tine Henrichsen Schnack, Wojciech Skovrider-Ruminski, Claus Hogdall, Jan Blaakaer
BACKGROUND: The etiological cause of ovarian cancer is poorly understood. It has been theorized that bacterial or viral infection as well as pelvic inflammatory disease could play a role in ovarian carcinogenesis. AIM: To review the literature on studies examining the association between ovarian cancer and bacterial or viral infection or pelvic inflammatory disease. METHODS: Database search through MEDLINE, applying the medical subject headings: "Ovarian neoplasms", AND "Chlamydia infections", " Neisseria gonorrhoeae ", " Mycoplasma genitalium ", "Papillomaviridae", or "pelvic inflammatory disease"...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28507330/flatbed-epi-relief-contrast-cellular-monitoring-system-for-stable-cell-culture
#14
Tatsuya Osaki, Tatsuto Kageyama, Yuka Shimazu, Dina Mysnikova, Shintaro Takahashi, Shinichi Takimoto, Junji Fukuda
Consistent cell preparation is a fundamental preliminary step for understanding complex cellular mechanisms in various cell-based research fields, including basic cell biology, cancer research, and tissue engineering. However, certain elusive factors, such as cellular de-differentiation and contamination with mycoplasma or other types of cells, have compromised the reproducibility and reliability of cell-based approaches. Here, we propose an epi relief-contrast cellular monitoring system (eRC-CMS) that allows images of cells in a typical culture plate to be acquired, stored, and analysed for daily cell quality control...
May 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28418857/multi-factorial-modulation-of-colorectal-carcinoma-cells-motility-partial-coordination-by-the-tetraspanin-co-029-tspan8
#15
Yingying Zhu, Naouel Ailane, Monica Sala-Valdés, Farhad Haghighi-Rad, Martine Billard, Viet Nguyen, Raphael Saffroy, Antoinette Lemoine, Eric Rubinstein, Claude Boucheix, Céline Greco
Colorectal carcinoma cells Isreco1 display an ability to migrate controlled by a complex set of signals issued from the membrane. By comparing cells infected by mycoplasmas and mycoplasmas free cells, we have established that basal 2D migration is dependent on a double signal mediated by the collagen receptors integrins alpha1/2 and the Toll-Like receptor TLR2. The signal issued from mycoplasmas can be replaced by a TLR2 ligand and the functional effect is neutralized by silencing of MyD88. Following previous observation that downregulation of E-cadherin/p120 catenin increases cell motility, we now report that EGFR or CD44 inhibition have a similar effect on cell motility that is restricted to tetraspanin Co-029/tspan8 transduced IsrecoI cells (Is1-Co029)...
April 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28366838/trichomonas-vaginalis-infection-in-symbiosis-with-trichomonasvirus-and-mycoplasma
#16
Raina Fichorova, Jorge Fraga, Paola Rappelli, Pier Luigi Fiori
Trichomonas vaginalis is a protozoan with an extracellular obligatory parasitic lifestyle exclusively adapted to the human urogenital tract and responsible for nearly a quarter billion sexually transmitted infections worldwide each year. This review focuses on symbiotic Trichomonasvirus and mycoplasmas carried by the protozoan, their molecular features and their role in altering the human vaginal microbiome and the immunopathogenicity of the parasite. Improved diagnostics and larger clinical interventional studies are needed to confirm the causative role of protozoan symbionts in the variable clinical presentation of trichomoniasis and its morbid sequelae, including adverse reproductive outcome, susceptibility to viral infections and cancer...
November 2017: Research in Microbiology
https://www.readbyqxmd.com/read/28255773/cell-lines-authentication-and-mycoplasma-detection-as-minimun-quality-control-of-cell-lines-in-biobanking
#17
C Corral-Vázquez, R Aguilar-Quesada, P Catalina, G Lucena-Aguilar, G Ligero, B Miranda, J A Carrillo-Ávila
Establishment of continuous cell lines from human normal and tumor tissues is an extended and useful methodology for molecular characterization of cancer pathophysiology and drug development in research laboratories. The exchange of these cell lines between different labs is a common practice that can compromise assays reliability due to contamination with microorganism such as mycoplasma or cells from different flasks that compromise experiment reproducibility and reliability. Great proportions of cell lines are contaminated with mycoplasma and/or are replaced by cells derived for a different origin during processing or distribution process...
June 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/28104015/-establishment-and-characterization-of-a-laryngeal-squamous-cell-carcinoma-cell-line
#18
R Wang, X C Bian, Y Q Liu, J G Fang, H Wang, H G Liu, M Lian, H Z Ma, L Feng, H Z Wang
Objective: To establish a laryngeal squamous cell carcinoma (LSCC) cell line through primary cell culture and observe its biological characteristics. Methods: Tissue block culture method was used for primary cell culture. After LSCC cells passed 25 times in vitro, the morphology of cells was observed, keratin was stained histochemically, cell cycle was tested by PI-FACS, and the specie of cells was detected by PCR and short tandem repeat(STR) typing. Results: This newly established LSCC cell line was named as TR-LCC-1, most of the cancer cells were polygonal shape, like the cobblestone, loss of contact inhibition and with overlapping growth...
January 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/27784492/-reversed-halo-sign-chest-ct-findings-in-5-patients-and-cause-analysis
#19
M Lu, Y H Chen, X Han, W Yang, J Zhang, X Zhu, H Zhu, B He, B Z Sun, W Z Yao
Objective: To describe diseases that may present with the reversed halo sign (RHS) on high-resolution CT, and therefore to improve the recognition of this thoracic radiological feature. Methods: We retrospectively reviewed the HRCT scans and medical records of 5 patients who presented with RHS on chest CT from Peking University Third Hospital. With "reversed halo sign, fairy ring, atoll sign" as the Chinese and English keywords, 420 cases from the literatures were also reviewed through PubMed, Wanfang and CNKI databases until August 2015...
October 12, 2016: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/27664744/mycoplasmal-lipoprotein-p37-binds-human-protein-her2
#20
Jun Wu, Lijuan Wu, Cheng Fang, Rong Nie, Jiamou Wang, Xuan Wang, Wenbin Liu
Mycoplasmas are a group of microbes that can cause human diseases. The mycoplasmal lipoprotein p37 promotes cancer metastasis, at least in part, by interacting with EGFR. In this study, we show that the p37 lipoprotein binds another member of the EGFR family, HER2, through the HER2 extracellular domain. The binding of p37-HER2 promotes phosphorylation of HER2 and activates the downstream signaling molecule Erk1/2. Because the HER2 signaling pathway contributes to breast tumor metastasis, our results imply that the mycoplasmal lipoprotein p37 may also be involved in breast cancer metastasis...
November 2016: Microbiological Research
keyword
keyword
59523
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"