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cancer and mycoplasma

Jun Wu, Lijuan Wu, Cheng Fang, Rong Nie, Jiamou Wang, Xuan Wang, Wenbin Liu
Mycoplasmas are a group of microbes that can cause human diseases. The mycoplasmal lipoprotein p37 promotes cancer metastasis, at least in part, by interacting with EGFR. In this study, we show that the p37 lipoprotein binds another member of the EGFR family, HER2, through the HER2 extracellular domain. The binding of p37-HER2 promotes phosphorylation of HER2 and activates the downstream signaling molecule Erk1/2. Because the HER2 signaling pathway contributes to breast tumor metastasis, our results imply that the mycoplasmal lipoprotein p37 may also be involved in breast cancer metastasis...
November 2016: Microbiological Research
Frances Mercer, Fitz Gerald I Diala, Yi-Pei Chen, Brenda M Molgora, Shek Hang Ng, Patricia J Johnson
Trichomonas vaginalis (Tv) is an extracellular protozoan parasite that causes the most common non-viral sexually transmitted infection: trichomoniasis. While acute symptoms in women may include vaginitis, infections are often asymptomatic, but can persist and are associated with medical complications including increased HIV susceptibility, infertility, pre-term labor, and higher incidence of cervical cancer. Heightened inflammation resulting from Tv infection could account for these complications. Effective cellular immune responses to Tv have not been characterized, and re-infection is common, suggesting a dysfunctional adaptive immune response...
August 2016: PLoS Neglected Tropical Diseases
André Lp de Abreu, Natália Malaguti, Raquel P Souza, Nelson S Uchimura, Érika C Ferreira, Monalisa W Pereira, Maria Db Carvalho, Sandra M Pelloso, Marcelo G Bonini, Fabrícia Gimenes, Marcia El Consolaro
The link between high-risk human Papillomavirus (HR-HPV) and other sexually transmitted diseases (STDs) in the risk of developing cervical cancer still unclear. Thus, in this report we investigated the rates of co-infections between HPV and other important non-HPV STDs in different cervical findings using a multiplex polymerase chain reaction (M-PCR) to simultaneously detect Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium, Trichomonas vaginalis, HSV-1 and -2, and Treponema pallidum. A total of 838 women aged 18 to 68 years were screened using Papanicolaou smears for cervical abnormalities, HPV and non-HPV STDs using PCR and M-PCR methods...
2016: American Journal of Cancer Research
Nicole Strittmatter, Anna Lovrics, Judit Sessler, James S McKenzie, Zsolt Bodai, M Luisa Doria, Nora Kucsma, Gergely Szakacs, Zoltan Takats
Rapid evaporative ionization mass spectrometry (REIMS) was used for the rapid mass spectrometric profiling of cancer cell lines. Spectral reproducibility was assessed for three different cell lines, and the extent of interclass differences and intraclass variance was found to allow the identification of these cell lines based on the REIMS data. Subsequently, the NCI60 cell line panel was subjected to REIMS analysis, and the resulting data set was investigated for its distinction of individual cell lines and different tissue types of origin...
August 2, 2016: Analytical Chemistry
Jieping Chen, Kai Yao, Zaishang Li, Chuangzhong Deng, Liangjiao Wang, Xingsu Yu, Peili Liang, Qiankun Xie, Peng Chen, Zike Qin, Yunlin Ye, Zhuowei Liu, Fangjian Zhou, Zhenfeng Zhang, Hui Han
PURPOSE: To establish penile cancer (PeCa) cell lines for the study of molecular mechanisms of carcinogenesis and testing therapeutic reagents. MATERIALS AND METHODS: We successfully established two PeCa cell lines from fresh tumor tissues from 21 cases. One cell line named Penl1 was isolated from a lymph node metastasis (LNM) of penile squamous cell carcinoma (PeSCC), usual type and comprehensively characterized here. Our in-depth characterization analysis of the Penl1 cell line included morphology, tumorigenicity, genetic characteristics, protein expression, biology, and chemosensitivity...
June 16, 2016: Oncotarget
(no author information available yet)
No abstract text is available yet for this article.
2016: PloS One
Shahanavaj Khan, Mohammed Zakariah, Christian Rolfo, Lembrechts Robrecht, Sellappan Palaniappan
Although the idea of bacteria causing different types of cancer has exploded about century ago, the potential mechanisms of carcinogenesis is still not well established. Many reports showed the involvement of M. hominis in the development of prostate cancer, however, mechanistic approach for growth and development of prostate cancer has been poorly understood. In the current study, we predicted M. hominis proteins targeting in the mitochondria and cytoplasm of host cells and their implication in prostate cancer...
March 23, 2016: Oncotarget
Qiyan Xiong, Jia Wang, Yan Ji, Bo Ni, Bixiong Zhang, Qinghong Ma, Yanna Wei, Shaobo Xiao, Zhixin Feng, Maojun Liu, Guoqing Shao
Mycoplasma hyorhinis (M. hyorhinis) is a swine pathogen that is associated with various human cancers and contamination in cell cultures. However, no studies on the adhesion molecules of this pathogen have yet been reported. The variable lipoprotein (Vlp) family is an important surface component of M. hyorhinis. Herein, we performed several experiments to identify the function of the Vlp family in adherence to host cells. Seven recombinant Vlp (rVlp) proteins were expressed in Escherichia coli and purified by affinity chromatography...
April 15, 2016: Veterinary Microbiology
Daria A Burmistrova, Sergey V Tillib, Dmitry V Shcheblyakov, Inna V Dolzhikova, Dmitry N Shcherbinin, Olga V Zubkova, Tatiana I Ivanova, Amir I Tukhvatulin, Maxim M Shmarov, Denis Y Logunov, Boris S Naroditsky, Aleksandr L Gintsburg
Developing pathogen-specific recombinant antibody fragments (especially nanobodies) is a very promising strategy for the treatment of infectious disease. Nanobodies have great potential for gene therapy application due to their single-gene nature. Historically, Mycoplasma hominis has not been considered pathogenic bacteria due to the lack of acute infection and partially due to multiple studies demonstrating high frequency of isolation of M. hominis samples from asymptomatic patients. However, recent studies on the role of latent M...
2016: PloS One
Meng Xiangying, Wang Tao, Wu Shikai, Song Santai, Jiang Zefei
Everolimus has been used in patients with hormone receptor-positive breast cancer. This study reports that treatment with everolimus alone induced severe pulmonary injury in a patient with systemic metastatic breast cancer. A 58-yearold woman with systemic metastatic breast cancer was treated with everolimus alone for 4 weeks and developed severe cough and dyspnea. Computed tomography (CT) scan of the chest showed a progressive lung tumor accompanied by bilateral pulmonary homogeneous ground-glass opacity, especially in the inferior lobe of the left lung...
March 2, 2016: International Journal of Clinical Pharmacology and Therapeutics
Shahanavaj Khan, Mohammed Zakariah, Sellappan Palaniappan
Cancer has long been assumed to be a genetic disease. However, recent evidence supports the enigmatic connection of bacterial infection with the growth and development of various types of cancers. The cause and mechanism of the growth and development of prostate cancer due to Mycoplasma hominis remain unclear. Prostate cancer cells are infected and colonized by enteroinvasive M. hominis, which controls several factors that can affect prostate cancer growth in susceptible persons. We investigated M. hominis proteins targeting the nucleus of host cells and their implications in prostate cancer etiology...
August 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Denise Wohlmeister, Débora Renz Barreto Vianna, Virgínia Etges Helfer, Fabrícia Gimenes, Marcia Edilaine Lopes Consolaro, Regina Bones Barcellos, Maria Lucia Rossetti, Luciane Noal Calil, Andréia Buffon, Diogo André Pilger
The influence of different infectious agents and their association with human papillomavirus (HPV) in cervical carcinogenesis have not been completely elucidated. This study describes the association between cytological changes in cervical epithelium and the detection of the most relevant aetiological agents of sexually transmitted diseases. Samples collected from 169 patients were evaluated by conventional cytology followed by molecular analysis to detect HPV DNA, Chlamydia trachomatis, herpes simplex virus 1 and 2,Neisseria gonorrhoeae, Mycoplasma genitalium, Trichomonas vaginalis, andTreponema pallidum, besides genotyping for most common high-risk HPV...
February 2016: Memórias do Instituto Oswaldo Cruz
Shiqin Yuan, Like Qu, Chengchao Shou
Mycoplasma infection in human and its contamination in cell cultures are worldwide problems. The drugs currently available for preventing or treating mycoplasma infection suffer from low sensitivity, strong resistance and high toxicity. Our previous work showed that Mycoplasma hyorhinis (M. hyorhinis) infection was mediated by the interaction between p37 of M. hyorhinis and Annexin A2 (ANXA2) of host cells, however the translational value of this mechanism was unknown. Herein, we synthesized the N-terminal of ANXA2 polypeptide (A2PP) and found that A2PP could decrease the infection of M...
2016: PloS One
Amber Cathie Gomersall, Huy Anh Phan, Sylvana Iacuone, Song Feng Li, Roger W Parish
The p37 protein at the surface of Mycoplasma hyorhinis cells forms part of a high-affinity transport system and has been found associated with animal and human cancers. Here we show in NIH3T3 fibroblasts, p37 rapidly induces the expression of genes implicated in inflammation and cancer progression. This gene activation was principally via the Tlr4 receptor. Activity was lost from p37 when the C-terminal 20 amino acids were removed or the four amino acids specific for the hydrogen bonding of thiamine pyrophosphate had been replaced by valine...
2015: PloS One
Shankargouda Patil, Roopa S Rao, A Thirumal Raj
No abstract text is available yet for this article.
July 2015: Journal of International Oral Health: JIOH
Mariana Magaña-Contreras, Adriana Contreras-Paredes, Alma Chavez-Blanco, Marcela Lizano, Yanira De la Cruz-Hernandez, Erick De la Cruz-Hernandez
Cervical cancer development has been mainly associated with persistent human papillomavirus (HPV) infections. However, HPV infection is unlikely to be sufficient to cause cervical cancer, and the contribution of other sexually transmitted infections (STIs) could be the determining factor for cervical lesion-progression. The aim of this study was to estimate the prevalence of STIs associated with HPV-positivity in 201 cervical samples from patients who underwent annual routine gynecological exams. The overall prevalence of STIs was 57...
December 2015: Journal of Medical Virology
Andrei V Chernov, Leticia Reyes, Zhenkang Xu, Beatriz Gonzalez, Georgiy Golovko, Scott Peterson, Manuel Perucho, Yuriy Fofanov, Alex Y Strongin
Aberrant DNA methylation is frequently observed in disease, including many cancer types, yet the underlying mechanisms remain unclear. Because germline and somatic mutations in the genes that are responsible for DNA methylation are infrequent in malignancies, additional mechanisms must be considered. Mycoplasmas spp., including Mycoplasma hyorhinis, efficiently colonize human cells and may serve as a vehicle for delivery of enzymatically active microbial proteins into the intracellular milieu. Here, we performed, for the first time, genome-wide and individual gene mapping of methylation marks generated by the M...
2015: Epigenetics: Official Journal of the DNA Methylation Society
Meijia Yang, Mei Tang, Xianjun Ma, Lijia Yang, Jiangpeng He, Xirui Peng, Gang Guo, Liangxue Zhou, Na Luo, Zhu Yuan, Aiping Tong
Antimicrobial peptides (AMPs) are an evolutionarily conserved component of the innate immune response that provides host defence at skin and mucosal surfaces. Here, we report the identification and characterization of a new type human AMPs, termed AP-57 (Antimicrobial Peptide with 57 amino acid residues), which is also known as C10orf99 (chromosome 10 open reading frame 99). AP-57 is a short basic amphiphilic peptide with four cysteines and a net charge +14 (MW = 6.52, PI = 11.28). The highest expression of AP-57 were detected in the mucosa of stomach and colon through immunohistochemical assay...
February 13, 2015: Biochemical and Biophysical Research Communications
Claudia Maletzki, Michael Gock, Martin Randow, Ernst Klar, Maja Huehns, Friedrich Prall, Michael Linnebacher
AIM: To generate novel tumor models for preclinical validation of biomarkers that allow drug response prediction and individual therapeutic decisions. METHODS: Cell line establishment was conducted by both direct in vitro culturing and in vivo xenografting followed by in vitro culturing procedure. A comprehensive characterization was subsequently performed. This included quality control, consisting of the confirmation of human and colorectal cancer (CRC) origin by DNA fingerprint and epithelial cell adhesion molecule (EpCAM) staining, as well as mycoplasma and human virus testing...
January 7, 2015: World Journal of Gastroenterology: WJG
Hongying Duan, Like Qu, Chengchao Shou
Persistent infection of Mycoplasma hyorhinis (M. hyorhinis) was associated with gastric cancer cell migration and invasion, but the mechanisms were not well understood. Herein, we found that M. hyorhinis activated phosphoinositide 3-kinase (PI3K)-AKT signaling axis in gastric cancer cell lines. Epidermal growth factor receptor (EGFR) was upstream of PI3K-AKT signaling in the context of M. hyorhinis infection, because phosphorylation of AKT Serine 473 was almost completely attenuated by the EGFR inhibitor AG1478 or by EGFR knockdown...
2014: Cancer Cell International
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