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Art F Y Poon, Bethany L Dearlove
No abstract text is available yet for this article.
March 13, 2018: Journal of Infectious Diseases
Ghadah Abdulrahman Alhekail, Alaa Althubaiti, Sulaiman AlQueflie
BACKGROUND: The prevalence of both asthma and obesity are increasing. Although some studies suggest an association between body mass index (BMI) and frequency of emergency department (ED) visits and hospitalization for asthma exacerbation, any association remains unproven. OBJECTIVE: Estimate the frequency of asthma exacerbation in obese children, and identify any relationship between BMI and frequency of ED visits and hospitalization for asthma exacerbation. DESIGN: Retrospective review of medical records...
November 2017: Annals of Saudi Medicine
Mary Mahony, Andrea Dwyer, Raschelle Barkume, Allison Strochlic, Fabien Jeannerot, Thomas Stüdeli
OBJECTIVES: The multi-dose, pre-filled GONAL-f® RFF Redi-ject® (follitropin alfa injection) pen injector was updated following feedback on user experience and pen functionality, as part of a continuous assessment program. Human-factors engineering (HFE) evaluations were conducted to confirm that the updated pen injector could be used by intended users to safely and effectively perform critical tasks identified by the risk-management plan. METHODS: Five rounds of formative evaluation and a simulated-use summative evaluation of the pen injector, instructions for use (IFU), and training video were conducted by HFE specialists or the intended users of the pen injector...
January 2018: Expert Opinion on Drug Delivery
Wei Liu, Xiao-Hong Fu, Si-Yuan Huang, Yan-Cheng Shi, Lin-Lin Shi, Jian Gu
This experiment was aimed to discuss the protective effect and mechanism of total lignans from Tibetan medicinal Herpetospermum seeds on carbon tetrachloride (CCl4)-induced liver fibrosis in rats. Forty-eight male Sprague-Dawley rats were randomly divided into the blank control group (G1), model group (G2), total lignans high, middle and low dose groups (400,200, and 100 mg•kg⁻¹•d⁻¹)(G3/4/5) and the glycyrrhizin positive control group (25 mg•kg⁻¹•d⁻¹)(G6), n=8 in each group. The rats in blank group received normal feeding; the rats in model group, total lignans low, middle and high dose groups and glycyrrhizic group were subcutaneously in jected with 3 mL•kg⁻¹ olive oilsolution containing 40%CCl4 every two or three days for Eight weeks...
February 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Yan Su, Eliezer Romeu-Bonilla, Athanasia Anagnostou, David Fitz-Patrick, William Hearl, Teri Heiland
Japanese Red Cedar (JRC) pollen induced allergy affects one third of Japanese and the development of effective therapies remains an unachieved challenge. We designed a DNA vaccine encoding CryJ2 allergen from the JRC pollen and Lysosomal Associated Membrane Protein 1 (LAMP-1) to treat JRC allergy. These Phase IA and IB trials assessed safety and immunological effects of the investigational CryJ2-LAMP DNA vaccine in both non-sensitive and sensitive Japanese expatriates living in Honolulu, Hawaii. In the Phase IA trial, 6 JRC non-sensitive subjects and 9 JRC and/or Mountain Cedar (MC) sensitive subjects were given 4 vaccine doses (each 4mg/1ml) intramuscularly (IM) at 14-day intervals...
December 2, 2017: Human Vaccines & Immunotherapeutics
F Zhang, X C Sun, C D Lu, W Zhang, H Shao, Z X Wang
Objective: To study the relationship between XRCC1 gene polymorphism and DNA damage in peripheral blood lymphocytes of workers exposed to coal tar pitch. Methods: 203 coal tar asphalt device operation area workers (exposure group) and 76 logistics management personnel (control group) as the research ob-ject, determination of 1-hydroxypyrene concentrations in the urine as polycyclic aromatic hydrocarbons expo-sure dose, using the alkaline comet assay evaluation a peripheral blood lymphocyte DNA damage degree, using TaqMan MGB real time PCR method to detect XRCC1 gene 3 loci (XRCC1-194, XRCC1-280 and XRCC1-399) single nucleotide polymorphism...
January 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
João Ilgenfritz, Ricardo Dutra Aydos, Iandara Schettert Silva, Rondon Tosta Ramalho, João Ilgenfritz, Gerson Gattats Orro de Campos, Ricardo Kenithi Nakamura, Danilo M Zanello Guerisoli, Wilson de Barros Cantero
Purpose: To compare the use of a new cyanoacrylate-based surgical glue and suture with sepa-rate points in skin wounds closure. Methods: Thirty-six rats were subjected to a 4cm dorsal longitudinal incision. Twelve were sub-jected to simple suture with polyamide 6-0, 12 rats underwent wall synthesis using Dermabond(r) and 12 was performed cutaneous synthesis with N-2-Butyl-Cyanoacrylate. Twelve of each group was euthanized on the seventh postoperative day, their blood was taken to biochemical tests and a layer of skin and subcutaneous tissue surrounding the surgical scar was randomly divided in two segments, to the submission of tension tests and to histological study...
January 2017: Acta Cirúrgica Brasileira
Guillaume Lautrette, Barbara Wicher, Brice Kauffmann, Yann Ferrand, Ivan Huc
A synthetic helical aromatic oligoamide foldamer receptor with high affinity and selectivity for tartaric acid was subjected to a structure-based evolution of its sequence via mutations, additions, and deletions of monomers to produce a new receptor having high affinity and selectivity for malic acid, a guest that differs from tartaric acid by a single oxygen atom. Seven iteratively modified sequences were synthesized. Detailed structural investigations of host-guest complexes were carried out systematically to guide the design of the next generation...
August 17, 2016: Journal of the American Chemical Society
Maria Ignacak, Natalia Celejewska-Wójcik, Krzysztof Wójcik, Kinga Sałapa, Ewa Konduracka, Marek Sanak, Katarzyna Tyrak, Krzysztof Sładek, Jacek Musiał, Lucyna Mastalerz
The aim of this pilot study was to evaluate changes in the concentration of prostaglandin E2 (PGE2) in induced sputum supernatant in 3 groups: sub- jects with NSAID-exacerbated respira- tory disease (NERD), aspirin tolerant asthma (ATA) and healthy controls (HC), before and after oral aspirin chal- lenge test. The study was conducted in the years 2014-2015 at the Clinical Department of the Pulmonology Clinic at the University Hospital in Cracow. 43 patients were enrolled in the study (NERD - n = 15, ATA - n = 15 and HC - n = 13)...
2016: Przegla̧d Lekarski
Alessandro Giacomoni, Stefano Di Sandro, Matteo Donadon, Andrea Lauterio, Luca Belli, Iacopo Mangoni, Plamen Mihaylov, Giacomo Concone, Luciano De Carlis
BACKGROUND/AIMS: Selection of patients with hepa- to-cellular carcinoma for liver transplantation is gen- erally performed according to the so-called Milan cri- teria. The aim of this study was to learn whether, after down-staging loco-regional therapies, patients origi- nally non-fulfilling the MC (Milan-OUT) meet these criteria (Milan-IN). METHODOLOGY: Between January 2000 and December 2008, 172 patients with HCC re- ceived LT at our Department. Of these, 142 were sub- jected to DS before LT...
June 2015: Hepato-gastroenterology
Mehdi Sharifi Tabar, Mahdi Hesaraki, Fereshteh Esfandiari, Fazel Sahraneshin Samani, Haghighat Vakilian, Hossein Baharvand
OBJECTIVE: Genetic modification of human embryonic stem cells (hESCs) is critical for their extensive use as a fundamental tool for cell therapy and basic research. Despite the fact that various methods such as lipofection and electroporation have been applied to transfer the gene of interest (GOI) into the target cell line, however, there are few re- ports that compare all parameters, which influence transfection efficiency. In this study, we examine all parameters that affect the efficiency of electroporation and lipofection for transient and long-term gene expression in three different cell lines to introduce the best method and determinant factor...
2015: Cell Journal
G E Oliveira, E V R Von Pinho, T Andrade, J C Souza, F Caixeta, R A D C Ferreira
In this study, we analyzed heterosis, amylase enzyme gene expression, and the physiological quality of maize seeds with different genotypes and sizes, which were subjected to aging and not subjected to aging. We used seeds from 2 maize lines that differed with regard to physiological quality, the hybrid, and the reciprocal hybrid; they were classified into 2 sizes and were subjected to aging and not subjected to aging. Physiological quality was assessed by performing tests for germination, emergence, emergence speed index, and artificial aging...
2015: Genetics and Molecular Research: GMR
Aida Malek Mahdavi, Reza Mahdavi, Mohammad Lotfipour, Mohammad Asghari Jafarabadi, Elnaz Faramarzi
BACKGROUND: This study was aimed to assess agreement and diagnostic accuracy of the Iranian version of Mini Nutritional Assessment short-form (MNA-SF) against the original MNA, as a gold standard in community-dwelling elderly. METHODS: The full MNA and 9-item MNA-SF comprising questions regarding clinical status, dietary assessment and self-perception of health status and nutri-tion together with mid-arm and calf circumference measurements without in-cluding the body mass index (BMI) were completed for 205 volunteers aged 65 or older recruited from all over Markazi Province (Iran)...
2015: Health Promotion Perspectives
Cong-cong Zeng, Xi Liu, Wang-wang Liu, Ling Wang, Jin-guo Cheng, San-mei Chen, Guo-rong Chen
OBJECTIVE: To observe the effect and mechanism of curcumin derivative B06 on kidney from rats with hyperlipidemia and type 2 diabetes. METHODS: Thirty five male SD rats were randomly divided into five groups(n = 7): the normal control group, high-fat group, high-fat + B06-treatd group, diabetic group, diabetic + B06-treated group. After fed with high-fat diet for 4 weeks, the later two groups were in- jected with streptozotocin intraperitoneally to induce type 2 diabetes mellitus...
January 2015: Chinese Journal of Applied Physiology
K Ge, J J Wu, L Qian, M J Wu, F L Wang, B Xu, T Xie
We examined the relationship between type 2 diabetes and skin wound healing. GSE38396 was downloaded from the Gene Expression Omnibus database and preprocessed using the RMA function of the Affy package. Differentially expressed genes (DEGs) were identified using the limma package, then DAVID was applied to per-form Gene Ontology functional annotation and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis. MicroRNAs and their target genes were screened from the miRecords database and subjected to functional analysis...
2015: Genetics and Molecular Research: GMR
Uroš Babić, Ivan Soldatović, Dejana Vuković, Milena Šantrić Milićević, Mihailo Stjepanović, Dejan Kojić, Aleksandar Argirović, Vinka Vukotić
BACKGROUND/AIM: Global budget per calendar year is a traditional method of funding hospitals in Serbia. Diagnose related groups (DGR) is a method of hospital payment based on classification of patients into groups with clinically similar problems and similar utilization of hospital resources. The aim of this study was to compare current methods of hospital services payment with the projected costs by DRG payment method in urology. METHODS: The data were obtained from the information system used in the Clinical Hospital Center "Dr...
March 2015: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
Sylwia Wojda, Bogusława Szoka, Eugeniusz Sajewicz
PURPOSE: The aim of this study was to investigate wear and friction behaviour of tooth enamel against selected dental restorative materials. METHODS: The experimental material was obtained under simulated mastication, during which human tooth enamel was sub- jected to friction and wear in contact with composite dental materials: Estelite Sigma and FulFil Extra. RESULTS: The results have shown that the enamel's resistance to tribological wear is significantly higher than the resistance of the dental materials tested...
2015: Acta of Bioengineering and Biomechanics
William M Bertucci, Ahlem Arfaoui, Sebastien Duc, Thierry Letellier, Abderrahim Brikci
PURPOSE: The purpose of this study was to investigate the effect of whole body vibration in oxygen uptake during intense squatting exercise with an added weight and whole body vibration compared with the same exercise without vibration. METHODS: Nine male sub- jects performed three trials of dynamic squatting with an additional load of 50% of their body weight during 3 min. One trial without vibration, one trial with the frequency of 40 Hz and amplitude of 2 mm and one trial with the frequency of 40 Hz and amplitude of 4 mm...
2015: Acta of Bioengineering and Biomechanics
Silvia Comani, Lucia Velluto, Lorenzo Schinaia, Gianluigi Cerroni, Antonio Serio, Sandro Buzzelli, Sandro Sorbi, Biancamaria Guarnieri
A novel system for the neuro-motor rehabilitation of upper limbs was validated in three sub-acute post-stroke patients. The system permits synchronized cortical and kinematic measures by integrating high-resolution EEG, passive robotic device and Virtual Reality. The brain functional re-organization was monitored in association with motor patterns replicating activities of daily living (ADL). Patients underwent 13 rehabilitation sessions. At sessions 1, 7 and 13, clinical tests were administered to assess the level of motor impairment, and EEG was recorded during rehabilitation task execution...
November 2015: IEEE Transactions on Neural Systems and Rehabilitation Engineering
Jiwan Kumar Chettri, Jakob Skov, Rzgar M Jaafar, Bjørn Krossøy, Per W Kania, Inger Dalsgaard, Kurt Buchmann
When testing vaccine-induced protection an effective and reliable challenge method is a basic requirement and we here present a comparative study on different challenge methods used for infection of rainbow trout Oncorhynchus mykiss with Aeromonas salmonicida, a bacterial pathogen eliciting furunculosis. Fish were vaccinated with three different adjuvanted trivalent vaccines containing formalin killed A. salmonicida, Vibrio anguillarum O1 and O2a. These were 1) the commercial vaccine Alpha Ject 3000, 2) an experimental vaccine with water in paraffin oil adjuvant, 3) an experimental vaccine with water in paraffin oil in water adjuvant...
June 2015: Fish & Shellfish Immunology
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