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https://www.readbyqxmd.com/read/27428616/iterative-evolution-of-an-abiotic-foldamer-sequence-for-the-recognition-of-guest-molecules-with-atomic-precision
#1
Guillaume Lautrette, Barbara Wicher, Brice Kauffmann, Yann Ferrand, Ivan Huc
A synthetic helical aromatic oligoamide foldamer receptor with high affinity and selectivity for tartaric acid was subjected to a structure-based evolution of its sequence via mutations, additions, and deletions of monomers to produce a new receptor having high affinity and selectivity for malic acid, a guest that differs from tartaric acid by a single oxygen atom. Seven iteratively modified sequences were synthesized. Detailed structural investigations of host-guest complexes were carried out systematically to guide the design of the next generation...
August 17, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27197430/-induced-sputum-supernatant-prostaglandin-e2-during-oral-aspirin-challenge-of-asthmatic-patients-with-and-without-aspirin-hypersensitivity-and-healthy-controls-pilot-study
#2
Maria Ignacak, Natalia Celejewska-Wójcik, Krzysztof Wójcik, Kinga Sałapa, Ewa Konduracka, Marek Sanak, Katarzyna Tyrak, Krzysztof Sładek, Jacek Musiał, Lucyna Mastalerz
The aim of this pilot study was to evaluate changes in the concentration of prostaglandin E2 (PGE2) in induced sputum supernatant in 3 groups: sub- jects with NSAID-exacerbated respira- tory disease (NERD), aspirin tolerant asthma (ATA) and healthy controls (HC), before and after oral aspirin chal- lenge test. The study was conducted in the years 2014-2015 at the Clinical Department of the Pulmonology Clinic at the University Hospital in Cracow. 43 patients were enrolled in the study (NERD - n = 15, ATA - n = 15 and HC - n = 13)...
2016: Przegla̧d Lekarski
https://www.readbyqxmd.com/read/26902036/survival-after-liver-transplant-influence-of-progression-of-disease-and-of-restoration-of-the-milan-criteria-in-patients-with-hepato-cellular-carcinoma-undergoing-down-staging-procedures
#3
Alessandro Giacomoni, Stefano Di Sandro, Matteo Donadon, Andrea Lauterio, Luca Belli, Iacopo Mangoni, Plamen Mihaylov, Giacomo Concone, Luciano De Carlis
BACKGROUND/AIMS: Selection of patients with hepa- to-cellular carcinoma for liver transplantation is gen- erally performed according to the so-called Milan cri- teria. The aim of this study was to learn whether, after down-staging loco-regional therapies, patients origi- nally non-fulfilling the MC (Milan-OUT) meet these criteria (Milan-IN). METHODOLOGY: Between January 2000 and December 2008, 172 patients with HCC re- ceived LT at our Department. Of these, 142 were sub- jected to DS before LT...
June 2015: Hepato-gastroenterology
https://www.readbyqxmd.com/read/26464815/evaluating-electroporation-and-lipofectamine-approaches-for-transient-and-stable-transgene-expressions-in-human-fibroblasts-and-embryonic-stem-cells
#4
Mehdi Sharifi Tabar, Mahdi Hesaraki, Fereshteh Esfandiari, Fazel Sahraneshin Samani, Haghighat Vakilian, Hossein Baharvand
OBJECTIVE: Genetic modification of human embryonic stem cells (hESCs) is critical for their extensive use as a fundamental tool for cell therapy and basic research. Despite the fact that various methods such as lipofection and electroporation have been applied to transfer the gene of interest (GOI) into the target cell line, however, there are few re- ports that compare all parameters, which influence transfection efficiency. In this study, we examine all parameters that affect the efficiency of electroporation and lipofection for transient and long-term gene expression in three different cell lines to introduce the best method and determinant factor...
2015: Cell Journal
https://www.readbyqxmd.com/read/26345793/relationship-among-physiological-quality-heterosis-and-amylase-gene-expression-in-maize-seeds
#5
G E Oliveira, E V R Von Pinho, T Andrade, J C Souza, F Caixeta, R A D C Ferreira
In this study, we analyzed heterosis, amylase enzyme gene expression, and the physiological quality of maize seeds with different genotypes and sizes, which were subjected to aging and not subjected to aging. We used seeds from 2 maize lines that differed with regard to physiological quality, the hybrid, and the reciprocal hybrid; they were classified into 2 sizes and were subjected to aging and not subjected to aging. Physiological quality was assessed by performing tests for germination, emergence, emergence speed index, and artificial aging...
2015: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/26290825/evaluation-of-the-iranian-mini-nutritional-assessment-short-form-in-community-dwelling-elderly
#6
Aida Malek Mahdavi, Reza Mahdavi, Mohammad Lotfipour, Mohammad Asghari Jafarabadi, Elnaz Faramarzi
BACKGROUND: This study was aimed to assess agreement and diagnostic accuracy of the Iranian version of Mini Nutritional Assessment short-form (MNA-SF) against the original MNA, as a gold standard in community-dwelling elderly. METHODS: The full MNA and 9-item MNA-SF comprising questions regarding clinical status, dietary assessment and self-perception of health status and nutri-tion together with mid-arm and calf circumference measurements without in-cluding the body mass index (BMI) were completed for 205 volunteers aged 65 or older recruited from all over Markazi Province (Iran)...
2015: Health Promotion Perspectives
https://www.readbyqxmd.com/read/26016236/-protective-effect-of-curcumin-derivative-b06-on-kidney-of-type-2-diabetic-rats
#7
Cong-cong Zeng, Xi Liu, Wang-wang Liu, Ling Wang, Jin-guo Cheng, San-mei Chen, Guo-rong Chen
OBJECTIVE: To observe the effect and mechanism of curcumin derivative B06 on kidney from rats with hyperlipidemia and type 2 diabetes. METHODS: Thirty five male SD rats were randomly divided into five groups(n = 7): the normal control group, high-fat group, high-fat + B06-treatd group, diabetic group, diabetic + B06-treated group. After fed with high-fat diet for 4 weeks, the later two groups were in- jected with streptozotocin intraperitoneally to induce type 2 diabetes mellitus...
January 2015: Chinese Journal of Applied Physiology
https://www.readbyqxmd.com/read/25966254/bioinformatic-analysis-of-the-effect-of-type-ii-diabetes-on-skin-wound-healing
#8
K Ge, J J Wu, L Qian, M J Wu, F L Wang, B Xu, T Xie
We examined the relationship between type 2 diabetes and skin wound healing. GSE38396 was downloaded from the Gene Expression Omnibus database and preprocessed using the RMA function of the Affy package. Differentially expressed genes (DEGs) were identified using the limma package, then DAVID was applied to per-form Gene Ontology functional annotation and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis. MicroRNAs and their target genes were screened from the miRecords database and subjected to functional analysis...
2015: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/25958477/comparative-analysis-of-the-current-payment-system-for-hospital-services-in-serbia-and-projected-payments-under-diagnostic-related-groups-system-in-urology
#9
COMPARATIVE STUDY
Uroš Babić, Ivan Soldatović, Dejana Vuković, Milena Šantrić Milićević, Mihailo Stjepanović, Dejan Kojić, Aleksandar Argirović, Vinka Vukotić
BACKGROUND/AIM: Global budget per calendar year is a traditional method of funding hospitals in Serbia. Diagnose related groups (DGR) is a method of hospital payment based on classification of patients into groups with clinically similar problems and similar utilization of hospital resources. The aim of this study was to compare current methods of hospital services payment with the projected costs by DRG payment method in urology. METHODS: The data were obtained from the information system used in the Clinical Hospital Center "Dr...
March 2015: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
https://www.readbyqxmd.com/read/25952294/tribological-characteristics-of-enamel-dental-material-contacts-investigated-in-vitro
#10
Sylwia Wojda, Bogusława Szoka, Eugeniusz Sajewicz
PURPOSE: The aim of this study was to investigate wear and friction behaviour of tooth enamel against selected dental restorative materials. METHODS: The experimental material was obtained under simulated mastication, during which human tooth enamel was sub- jected to friction and wear in contact with composite dental materials: Estelite Sigma and FulFil Extra. RESULTS: The results have shown that the enamel's resistance to tribological wear is significantly higher than the resistance of the dental materials tested...
2015: Acta of Bioengineering and Biomechanics
https://www.readbyqxmd.com/read/25951821/effect-of-whole-body-vibration-in-energy-expenditure-and-perceived-exertion-during-intense-squat-exercise
#11
William M Bertucci, Ahlem Arfaoui, Sebastien Duc, Thierry Letellier, Abderrahim Brikci
PURPOSE: The purpose of this study was to investigate the effect of whole body vibration in oxygen uptake during intense squatting exercise with an added weight and whole body vibration compared with the same exercise without vibration. METHODS: Nine male sub- jects performed three trials of dynamic squatting with an additional load of 50% of their body weight during 3 min. One trial without vibration, one trial with the frequency of 40 Hz and amplitude of 2 mm and one trial with the frequency of 40 Hz and amplitude of 4 mm...
2015: Acta of Bioengineering and Biomechanics
https://www.readbyqxmd.com/read/25910194/monitoring-neuro-motor-recovery-from-stroke-with-high-resolution-eeg-robotics-and-virtual-reality-a-proof-of-concept
#12
Silvia Comani, Lucia Velluto, Lorenzo Schinaia, Gianluigi Cerroni, Antonio Serio, Sandro Buzzelli, Sandro Sorbi, Biancamaria Guarnieri
A novel system for the neuro-motor rehabilitation of upper limbs was validated in three sub-acute post-stroke patients. The system permits synchronized cortical and kinematic measures by integrating high-resolution EEG, passive robotic device and Virtual Reality. The brain functional re-organization was monitored in association with motor patterns replicating activities of daily living (ADL). Patients underwent 13 rehabilitation sessions. At sessions 1, 7 and 13, clinical tests were administered to assess the level of motor impairment, and EEG was recorded during rehabilitation task execution...
November 2015: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/25783001/comparative-evaluation-of-infection-methods-and-environmental-factors-on-challenge-success-aeromonas-salmonicida-infection-in-vaccinated-rainbow-trout
#13
COMPARATIVE STUDY
Jiwan Kumar Chettri, Jakob Skov, Rzgar M Jaafar, Bjørn Krossøy, Per W Kania, Inger Dalsgaard, Kurt Buchmann
When testing vaccine-induced protection an effective and reliable challenge method is a basic requirement and we here present a comparative study on different challenge methods used for infection of rainbow trout Oncorhynchus mykiss with Aeromonas salmonicida, a bacterial pathogen eliciting furunculosis. Fish were vaccinated with three different adjuvanted trivalent vaccines containing formalin killed A. salmonicida, Vibrio anguillarum O1 and O2a. These were 1) the commercial vaccine Alpha Ject 3000, 2) an experimental vaccine with water in paraffin oil adjuvant, 3) an experimental vaccine with water in paraffin oil in water adjuvant...
June 2015: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/25781621/chronic-inflammatory-disease-and-osteopathy-a-systematic-review
#14
REVIEW
Luca Cicchitti, Marta Martelli, Francesco Cerritelli
BACKGROUND: Chronic inflammatory diseases (CID) are globally highly prevalent and characterized by severe pathological medical conditions. Several trials were conducted aiming at measuring the effects of manipulative therapies on patients affected by CID. The purpose of this review was to explore the extent to which osteopathic manipulative treatment (OMT) can be benefi-cial in medical conditions also classified as CID. METHODS: This review included any type of experimental study which enrolled sub-jects with CID comparing OMT with any type of control procedure...
2015: PloS One
https://www.readbyqxmd.com/read/25693613/-poet2-registry-comparison-of-annual-direct-medical-costs-of-treating-type-2-diabetes-after-addition-of-insulin-nph-or-insulin-glargine-to-oral-antidiabetic-therapy-in-the-czech-republic
#15
COMPARATIVE STUDY
Milan Kvapil, Denisa Janíčková Žďarská, Josef Suchopár, Michal Prokeš, Jan Brož
INTRODUCTION: Poor glycemic control and the resulting development of complications of type 2 diabetes (DM2T) increase treatment costs. If adequate glycemic control cannot be achieved by lifestyle modifications and oral antidiabetic (OAD) therapy, initiation of insulin therapy is recommended. Cost effectiveness of basal insulins of the type NPH or glargine in combination with OAD for the treatment of DM2T was examined in a number of pharmacoeconomic studies. However, none of these studies were conducted in the Czech Republic...
January 2015: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/25276689/down-syndrome-screening-methods-in-iranian-pregnant-women
#16
Azizeh Farshbaf Khalili, Mahnaz Shahnazi, Khadijeh Hajizadeh, Mahmoud Shekari Khaniani
INTRODUCTION: Down syndrome is one of the most prevalent genetic diseases. Screening methods for this syndrome are easy and safe and are recommended to all pregnant women particularly mothers over 35 years of age. This study aimed to review the status of Down syndrome screening and related factors in Iranian pregnant women. METHODS: This descriptive analytical study was carried out in 2011. It included 400 women who were randomly selected from those referring to Alzahra Hospital (Tabriz, Iran) during their third trimester of pregnancy...
September 2012: Journal of Caring Sciences
https://www.readbyqxmd.com/read/25206564/treadmill-step-training-promotes-spinal-cord-neural-plasticity-after-incomplete-spinal-cord-injury
#17
Tiansheng Sun, Chaoqun Ye, Jun Wu, Zhicheng Zhang, Yanhua Cai, Feng Yue
A large body of evidence shows that spinal circuits are significantly affected by training, and that intrinsic circuits that drive locomotor tasks are located in lumbosacral spinal segments in rats with complete spinal cord transection. However, after incomplete lesions, the effect of treadmill training has been debated, which is likely because of the difficulty of separating spontaneous stepping from specific training-induced effects. In this study, rats with moderate spinal cord contusion were jected to either step training on a treadmill or used in the model (control) group...
September 25, 2013: Neural Regeneration Research
https://www.readbyqxmd.com/read/24149687/the-acute-effects-of-back-squats-on-vertical-jump-performance-in-men-and-women
#18
Chad A Witmer, Shala E Davis, Gavin L Moir
The aim of the present study was to investigate the acute effects of performing back squats on subsequent performance during a series of vertical jumps in men and women. Twelve men and 12 women were tested on three separate occasions, the first of which was used to determine their 1-repetition maximum (1-RM) parallel back squat. Following this, subjects performed a potentiation and a control treatment in a counterbalanced order. The potentiation treatment culminated with subjects performing parallel back squats with a load equivalent to 70% 1- RM for three repetitions, following which they performed one countermovement vertical jump (CMJ) for maximal height every three minutes for a total of 10 jumps...
2010: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/23711820/protein-transfection-of-mouse-lung
#19
Patrick Geraghty, Robert Foronjy
Increasing protein expression enables researchers to better understand the functional role of that protein in regulating key biological processes(1). In the lung, this has been achieved typically through genetic approaches that utilize transgenic mice(2,3) or viral or non-viral vectors that elevate protein levels via increased gene expression(4). Transgenic mice are costly and time-consuming to generate and the random insertion of a transgene or chronic gene expression can alter normal lung development and thus limit the utility of the model(5)...
2013: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/23678435/free-radical-scavenging-potential-and-essential-oil-composition-of-the-dorema-glabrum-fisch-c-a-mey-roots-from-iran
#20
Solmaz Asnaashari, Elmira Dadizadeh, Amir Hossein Talebpour, Morteza Eskandani, Hossein Nazemiyeh
INTRODUCTION: Dorema glabrum is an endangered species that grow in Transcaucasia and North West of Iran. The plant has extensive uses e.g. as an herbal remedy or food additive in these regions. The chemical composition of hydrodistilled oil of D. glabrum growing in Iran was analyzed by GC-MS for the first time. METHODS: The essential oil of air-dried roots was obtained by hydrodistillation using a Clevenger type apparatus. The oil was sub-jected to GC-MS analysis and its free radical scavenging properties were determined by DPPH method...
2011: BioImpacts: BI
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