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https://www.readbyqxmd.com/read/28346773/noninterventional-naturalistic-retrospective-study-to-describe-prescription-patterns-of-long-acting-injectable-antipsychotics-and-the-impact-of-introducing-a-new-atypical-antipsychotic-in-the-spanish-province-of-tarragona-catchment-area
#1
Ana M Gaviria, José Franco, Guillem Rico, Gerard Muntané, Cristina Sáez, Vanessa Sánchez-Gistau, Joan de Pablo, Elisabet Vilella
Background: We studied the patterns and predictors of long-acting injectable (LAI) antipsychotic (AP) use in the treatment of schizophrenia and the effect of introducing a new LAI (paliperidone palmitate [paliperidone-LAI]) in the Spanish province of Tarragona. Methods: This noninterventional, naturalistic, retrospective study included electronic medical record data from a large population-based database of 1,646 patients who were diagnosed with schizophrenia according to ICD-10 criteria and treated between January 2011 and December 2013...
March 23, 2017: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/28346310/the-potential-for-gabapentinoid-abuse-in-pain-management
#2
Tze Chao Wee
No abstract text is available yet for this article.
March 24, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28346282/screening-tools-to-assess-risk-of-opioid-abuse-in-the-canadian-primary-healthcare-setting
#3
Hollie Muir, Fran Seymour
Opioid therapy for patients with chronic pain is increasing in frequency along with rates of opioid abuse. Many screening tools are available to assess for the risk of opioid abuse. NPs should use screening tools that are cross-validated for use in chronic pain patients in the Canadian primary healthcare setting.
March 24, 2017: Nurse Practitioner
https://www.readbyqxmd.com/read/28346050/perception-of-canine-welfare-concerns-among-veterinary-students-practitioners-and-behavior-specialists-in-spain
#4
Isabel Luño, Jorge Palacio, Sylvia García-Belenguer, Ángela González-Martínez, Belén Rosado
Veterinarians are well placed to supervise and ensure canine welfare. However, the perception of animal welfare among veterinarians may vary depending on the level of training and professional practice, including the specialization in animal behavior and welfare. The aim of this study was to survey the perception of canine welfare among veterinarians, including students, practitioners, and behavior specialists. A scale-based questionnaire including 12 issues affecting canine welfare was adapted from Yeates and Main and distributed to first-year (n=50) and fifth-year veterinary students (n=50), as well as veterinary practitioners (n=260) and specialists in behavioral medicine (n=50)...
March 27, 2017: Journal of Veterinary Medical Education
https://www.readbyqxmd.com/read/28345745/in-vitro-and-in-vivo-assessment-of-the-abuse-potential-of-pf614-a-novel-bio-md%C3%A2-prodrug-of-oxycodone
#5
D Lynn Kirkpatrick, William K Schmidt, Ricardo Morales, John Cremin, Julie Seroogy, Craig Husfeld, Thomas Jenkins
OBJECTIVE: The need for pain medication which will not lead to abuse is well recognized. Ensysce has designed prodrug analogs of the commonly used pain medications including hydromorphone, oxycodone (OC), hydrocodone, and morphine that limit their use to oral delivery, two of which are in clinical development. This study was undertaken to demonstrate that PF614, an extended-release prodrug of OC, allows the release of OC as designed when delivered orally, yet it resists ex vivo extraction with household chemicals and is pharmacologically inactive when administered by nonoral routes (nasal and parenteral), thereby substantially reducing its intravenous (IV) and intranasal abuse potential...
January 2017: Journal of Opioid Management
https://www.readbyqxmd.com/read/28345608/maoa-rs1137070-and-heroin-addiction-interactively-alter-gray-matter-volume-of-the-salience-network
#6
Yan Sun, Linwen Liu, Jiajia Feng, Weihua Yue, Lin Lu, Yong Fan, Jie Shi
The rs1137070 polymorphism of monoamine oxidase A (MAOA) is associated with alcoholism and smoking behavior. However, the association between rs1137070 and heroin addiction remains unclear. In this study, we examined the allelic distribution of rs1137070 in 1,035 heroin abusers and 2,553 healthy controls and investigated the interactive effects of rs1137070 and heroin addiction on gray matter volume (GMV) based on 78 heroin abusers and 79 healthy controls. The C allele frequency of rs1137070 was significantly higher in heroin abusers...
March 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28345440/the-economic-burden-of-opioid-abuse-updated-findings
#7
Noam Y Kirson, Lauren M Scarpati, Caroline J Enloe, Aliya P Dincer, Howard G Birnbaum, Tracy J Mayne
BACKGROUND: Opioid pain relievers can be highly effective in providing relief for patients suffering from pain. At the same time, prescription opioid abuse, dependence, overdose, and poisoning (hereinafter "abuse") have become a national public health concern. Opioid abuse is also costly: previous estimates of the annual excess costs of opioid abuse to payers range from approximately $10,000 to $20,000 per patient. OBJECTIVES: To (a) provide a comprehensive, current estimate of the economic burden of opioid abuse to commercial payers and (b) explore the drivers of these excess costs of abuse...
April 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28345210/geographic-disparities-in-availability-of-opioid-use-disorder-treatment-for-medicaid-enrollees
#8
Amanda J Abraham, Christina M Andrews, Marissa E Yingling, Jerry Shannon
OBJECTIVE: To examine county-level geographic variation in treatment admissions among opioid treatment programs (OTPs) that accept Medicaid in the continental United States. DATA SOURCES/STUDY SETTING: Data come from the 2012 National Survey of Substance Abuse Treatment Services. STUDY DESIGN/DATA COLLECTION: We used local measures of spatial autocorrelation (LISA) analysis to identify (1) clusters of counties with higher and lower than average rates of opioid use disorders and (2) clusters of counties with higher and lower than average treatment admissions among OTPs that accept Medicaid, adjusting for county population size...
March 27, 2017: Health Services Research
https://www.readbyqxmd.com/read/28345016/-by-slapping-their-laps-the-patient-will-know-that-you-truly-care-for-her-a-qualitative-study-on-social-norms-and-acceptability-of-the-mistreatment-of-women-during-childbirth-in-abuja-nigeria
#9
Meghan A Bohren, Joshua P Vogel, Özge Tunçalp, Bukola Fawole, Musibau A Titiloye, Akinpelu Olanrewaju Olutayo, Agnes A Oyeniran, Modupe Ogunlade, Loveth Metiboba, Olubunmi R Osunsan, Hadiza A Idris, Francis E Alu, Olufemi T Oladapo, A Metin Gülmezoglu, Michelle J Hindin
BACKGROUND: Many women experience mistreatment during childbirth in health facilities across the world. However, limited evidence exists on how social norms and attitudes of both women and providers influence mistreatment during childbirth. Contextually-specific evidence is needed to understand how normative factors affect how women are treated. This paper explores the acceptability of four scenarios of mistreatment during childbirth. METHODS: Two facilities were identified in Abuja, Nigeria...
December 2016: SSM—Population Health
https://www.readbyqxmd.com/read/28344568/time-is-money-the-decision-making-of-smartphone-high-users-in-gain-and-loss-intertemporal-choice
#10
Zixuan Tang, Huijun Zhang, An Yan, Chen Qu
Nowadays the smartphone plays an important role in our lives. While it brings us convenience and efficiency, its overuse can cause problems. Although a great number of studies have demonstrated that people affected by substance abuse, pathological gambling, and internet addiction disorder have lower self-control than average, scarcely any study has investigated the decision making of smartphone high users by using a behavioral paradigm. The present study employed an intertemporal task, the Smartphone Addiction Inventory (SPAI) and the Barratt Impulsiveness Scale 11th version (BIS-11) to explore the decision control of smartphone high users in a sample of 125 college students...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28343774/immunogenicity-and-safety-of-a-high-dose-hepatitis-b-vaccine-among-patients-receiving-methadone-maintenance-treatment-a-randomized-double-blinded-parallel-controlled-trial
#11
Jing Shi, Yongliang Feng, Linying Gao, Dan Feng, Tian Yao, Shan Shi, Yawei Zhang, Xiaofeng Liang, Suping Wang
BACKGROUND AND AIMS: To explore whether the immunization with high-dose (60μg) hepatitis B vaccines in patients receiving methadone maintenance treatment (MMT) could yield a superior protection against hepatitis B infection than did the standard dose (20μg). METHODS: We conducted a randomized, double-blinded, parallel-controlled trial in MMT patients. Patients with serologically negative hepatitis B surface antigen (HBsAg) and hepatitis B surface antibody (anti-HBs) were randomized in a ratio of 1:1 to receive three intramuscular injections of 20μg or 60μg recombinant hepatitis B vaccine at months 0, 1, and 6...
March 23, 2017: Vaccine
https://www.readbyqxmd.com/read/28343650/-surveillance-system-on-drug-abuse-interest-of-the-french-national-oppidum-program-of-french-addictovigilance-network
#12
Elisabeth Frauger, Liselotte Pochard, Quentin Boucherie, Adeline Giocanti, Cécile Chevallier, Amélie Daveluy, Valérie Gibaja, Anne-Sylvie Caous, Céline Eiden, Nicolas Authier, Reynald Le Boisselier, Marylène Guerlais, Émilie Jouanjus, Marion Lepelley, Véronique Pizzoglio, Stéphanie Pain, Nathalie Richard, Joëlle Micallef
It is important to assess drug abuse liability in 'real life' using different surveillance systems. OPPIDUM ('Observation of illegal drugs and misuse of psychotropic medications') surveillance system anonymously collects information on drug abuse and dependence observed in patients recruited in specialized care centers dedicated to drug dependence. The aim of this article is to demonstrate the utility of OPPIDUM system using 2015 data. OPPIDUM is a cross-sectional survey repeated each year since 1995. In 2015, 5003 patients described the modality of use of 10,159 psychoactive drugs...
February 22, 2017: Thérapie
https://www.readbyqxmd.com/read/28343423/management-of-precipitated-opiate-withdrawal-syndrome-induced-by-nalmefene-mistakenly-prescribed-in-opiate-dependent-patients-a-review-for-clinicians
#13
Nicolas Franchitto, Benedicte Jullian, Juliette Salles, Fanny Pelissier, Benjamin Rolland
Nalmefene, a long-acting µ-opioid antagonist approved to treat alcohol use disorder, is occasionally mistakenly prescribed to opiate-dependent or opioid-treated patients. We review recent literature on drug-drug interactions between nalmefene and opioids that lead to precipitated opioid withdrawal, and focus on its management and planning for care at discharge. Areas covered: This article provides a brief and comprehensive review of management of precipitated opioid withdrawal syndrome when nalmefene is associated with an opioid, whether misused or legally prescribed...
March 27, 2017: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/28343112/the-impact-of-australian-legislative-changes-on-synthetic-cannabinoid-exposures-reported-to-the-new-south-wales-poisons-information-centre
#14
Rose Cairns, Jared A Brown, Naren Gunja, Nicholas A Buckley
BACKGROUND: The emergence of new psychoactive substances (NPS), including synthetic cannabinoid receptor agonists (SCRAs) poses novel challenges for drug regulation and public health. Misconceptions of safety and legality, coupled with the fact that NPS are undetectable on routine drugs screens contributes to their popularity. Concerns over the unpredictable toxicity and abuse potential of NPS has led to a variety of legislative responses worldwide. We wish to describe Australian trends in SCRA use, examining the effects of legislative changes on calls to Australia's largest poisons centre...
March 23, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28342989/patient-engagement-and-study-design-of-prop-up-a-multi-site-patient-centered-prospective-observational-study-of-patients-undergoing-hepatitis-c-treatment
#15
Donna M Evon, Carol E Golin, Paul Stewart, Michael W Fried, Shani Alston, Bryce Reeve, Anna S Lok, Richard K Sterling, Joseph K Lim, Nancy Reau, Souvik Sarkar, David R Nelson, K Rajender Reddy, Adrian M Di Bisceglie
BACKGROUND: New highly efficacious direct-acting antiviral (DAA) therapies are available to treat chronic hepatitis C viral (HCV) infection. Real-world, patient-centered data on harms and benefits associated with these therapies are needed. METHODS: PROP UP is a multi-center prospective observational study that plans to enroll 1600 patients starting treatment with recently-approved DAA regimens. Informed by extensive input from a HCV patient engagement group who prioritized outcomes most important to them, patient-reported outcomes will be characterized using surveys at five time points: Baseline (T1), treatment week 4 (T2), end of treatment (T3), 12weeks post-treatment (T4), 12months post-treatment (T5)...
March 22, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28342623/mother-newborn-health-indicators-in-possible-victims-of-gender-based-violence-during-pregnancy
#16
Juan Miguel Martínez-Galiano
BACKGROUND: Pregnancy increases the risk of gender-based violence, considered an underdiagnosed public health problem. OBJECTIVE: To determine the association between the situation of possible gender-based violence in the pregnant woman and variables related to pregnancy, labor, puerperium, and newborn health. DESIGN: An observational multicenter study. SETTINGS: Three Spanish hospitals during 2015. PARTICIPANTS: 141 pregnant women in which information is collected sociodemographic variables and data related to pregnancy, labor, and puerperium were gathered by interview and from clinical records...
April 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/28342504/retraction-notice-to-long-term-trends-1986-2003-in-the-use-of-coronary-reperfusion-strategies-in-patients-hospitalized-with-acute-myocardial-infarction-in-central-massachusetts-int-j-cardiol-131-2008-83-89
#17
Robert J Goldberg, Frederick A Spencer, Joseph Okolo, Darleen Lessard, Jorge Yarzebski, Joel M Gore
This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor-in-Chief and Author. This article is a duplicate of a paper that has already been published in the Journal of Thrombosis and Thrombolysis, 23 (2007) 163-71. http://dx.doi.org/10.1007/s11239-006-9029-0. One of the conditions of submission of a paper for publication is that authors declare explicitly that the paper is not under consideration for publication elsewhere...
May 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28342226/psychopathology-and-personality-traits-associated-with-driving-while-intoxicated-in-beijing-china-implications-for-interventions
#18
Rong-Jiang Zhao, Wei Sun, Li-Li Zhang, Yan-Ping Bao, Liang Huang, Ping Dong, Shuang-Jiang Zhou, Zhi-Qing Wang, Thomas R Kosten, Hong-Qiang Sun
BACKGROUND AND OBJECTIVES: Driving while intoxicated (DWI) represents an area of grave concern in China, yet little research has focused on it or on the personality traits and psychiatric disorders among these drivers. METHODS: We enrolled 325 of 382 residents charged with DWI in a compulsory detention center in Beijing, China. And 351 male drivers who had never had any alcohol arrests as control participants. All were screened for Axis I disorders using the Chinese version of the Structured Clinical Interview for the Diagnostic Statistical Manual of Mental Disorders IV-TR (SCID), the Minnesota Multiphasic Personality Inventory (MMPI-2), and the Sixteen Personality Factor Questionnaire (16PF)...
March 24, 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/28342144/transformational-analysis-and-religious-experience
#19
Christian Gostečnik, Tanja Repič Slavič, Tanja Pate, Robert Cvetek
The therapeutic process, which taps into the individual's most vulnerable inner experience, can always reach a radical reversal of one's perception of religion and God, which may be askew due to deep trauma. This transformation caused by the therapeutic relationship can reciprocally help to resolve one's deep and complicated issues, while at the same time radically altering their relationship to religion. This is especially apparent among those who were cruelly and traumatically abused in their earliest stages of development...
March 24, 2017: Journal of Religion and Health
https://www.readbyqxmd.com/read/28342008/alterations-of-the-oxidative-status-in-rat-hippocampus-and-prodepressant-effect-of-chronic-testosterone-enanthate-administration
#20
Jovana Joksimović, Dragica Selaković, Vladimir Jakovljević, Vladimir Mihailović, Jelena Katanić, Tatjana Boroja, Gvozden Rosić
In a last few decades, anabolic-androgenic steroids (AASs) abuse has become serious health concern especially among adolescents. AASs abuse has been reported to be involved in pathogenesis of various mood disorders, including depression. In order to evaluate the effects of chronic (6 weeks) testosterone enanthate (TE) treatment in supraphysiological dose and exercise on depression-like behavior in rats, 32 male rats were divided into four groups: control (C), testosterone enanthate (T, 20 mg/kg/w, s.c.), exercise (E, swimming for 1 h/day), and combined group-testosterone enanthate plus exercise (T + E)...
March 24, 2017: Molecular and Cellular Biochemistry
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