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https://www.readbyqxmd.com/read/28830124/postmortem-fluid-and-tissue-concentrations-of-thc-11-oh-thc-and-thc-cooh
#1
Sunday R Saenz, Russell J Lewis, Mike K Angier, Jarrad R Wagner
Marijuana is the most commonly abused illicit drug worldwide. Marijuana is used for its euphoric and relaxing properties. However, marijuana use has been shown to result in impaired memory, cognitive skills and psychomotor function. The Federal Aviation Administration's Civil Aerospace Medical Institute conducts toxicological analysis on aviation fatalities. Due to severe trauma associated with aviation accidents, blood is not always available; therefore, the laboratory must rely on specimens other than blood for toxicological analysis in ~30-40% of cases...
July 1, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28830123/application-of-a-urine-and-hair-validated-lc-ms-ms-method-to-determine-the-effect-of-hair-color-on-the-incorporation-of-25b-nbome-25c-nbome-and-25i-nbome-into-hair-in-the-rat
#2
Lorna A Nisbet, Rafael Venson, Fiona M Wylie, Karen S Scott
NBOMes are a group of new psychoactive substances derived from phenethylamines. Recreational abuse is thought to have begun in 2010 and they are commonly associated with the "club drug" scene. They are administered in liquid form or as blotters due to their high potency. An LC-MS-MS method was validated using Scientific Working Group for Forensic Toxicology parameters for the detection of 25B-, 25C- and 4-iodo-2,5-dimethoxy-N-[(2-methoxyphenyl)methyl]-benzeneethanamine (25I-NBOMe) using 4-bromo-2,5-dimethoxy-N-[(2-methoxyphenyl)methyl]-benzeneethanamine (25B-NBOMe)-D3 as internal standard for urine and hair...
July 1, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28830119/confirmation-of-carfentanil-u-47700-and-other-synthetic-opioids-in-a-human-performance-case-by-lc-ms-ms
#3
Joshua Seither, Lisa Reidy
Recently, it has been documented that there has been a rise in synthetic opioid abuse. Synthetic opioids are compounds that were created to act as agonists for the opioid receptors. Like synthetic cannabinoids, most of these compounds were created by research groups or pharmaceutical companies in an attempt to find compounds that have medicinal use. Synthetic opioids have severe health implications when abused that can include hospitalization and death. Due to the high potency and the low dose required to produce the desired effects for these compounds, it was hypothesized that they may not be detectable in human performance case samples...
July 1, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28830118/two-fatal-intoxications-involving-3-methoxyphencyclidine
#4
Christie Mitchell-Mata, Brittany Thomas, Brianna Peterson, Fiona Couper
3- and 4-methoxyphencyclidine (3-MeO-PCP, 4-MeO-PCP), structural analogs of phencyclidine (PCP), were among the first legal PCP alternatives to show up on the novel psychoactive substances (NPS) market in Europe in the 2000s. Their structural similarities to PCP and ketamine likely contribute to their demonstrated dissociative anesthetic effects. Limited information exists in the literature about toxic and lethal concentrations of these drugs in biological samples. This case report presents the first two death cases in Washington State in which 3-MeO-PCP was identified...
July 1, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28829652/pediatric-prehospital-refusal-of-medical-assistance-association-with-suspected-abuse-or-neglect
#5
Felicia Mix, Lucas A Myers, Anuradha Luke, Matthew D Sztajnkrycer
INTRODUCTION: Unlike adult refusal of medical assistance (RMA), pediatric refusal is not initiated by the patient. This lack of autonomy may permit neglect by the guardian through denial of necessary treatment. The purpose of the current study was to determine whether pediatric RMA was associated with suspected abuse or neglect (SAN). METHODS: This was a retrospective single EMS agency cross-sectional analysis of calls between January 1, 2011 and December 31, 2015 for patients <18 years of age resulting in RMA...
August 22, 2017: Prehospital Emergency Care
https://www.readbyqxmd.com/read/28829649/paramedic-students-knowledge-attitudes-and-preparedness-to-manage-intimate-partner-violence-patients
#6
Simon Sawyer, Jan Coles, Angela Williams, Peter Lucas, Brett Williams
BACKGROUND: Intimate partner violence (IPV) refers to abuse transpiring between people in an intimate relationship. Intimate partner violence is a leading cause of morbidity and mortality for women that paramedics frequently report encountering and yet paramedics rarely receive formal education or training to manage. The response of paramedics to IPV is likely to be directed by their individual knowledge, attitudes, and preparedness; all of which are currently unknown. This study aimed to measure paramedic students' knowledge, attitudes, and preparedness to manage IPV patients, and provides baseline data to inform the development of contemporary curricula...
August 22, 2017: Prehospital Emergency Care
https://www.readbyqxmd.com/read/28829630/associated-factors-of-readiness-to-change-in-young-adult-risky-drinkers
#7
Ebon S Alley, Mary M Velasquez, Kirk Von Sternberg
BACKGROUND: Readiness to change alcohol use has been associated with a number of predictors including emotional distress, drinking severity, and consequence severity, as well as with static demographic factors such as gender and race/ethnicity. OBJECTIVE: To examine the relationships among these variables and readiness to change alcohol use in young adults. METHODS: Structural equation modeling was used to test pathways of readiness to change in 1,256 young adult patients (78% male/22% female) ages 18-29 who were provided screening, brief intervention and referral to treatment (SBIRT) as part of a Substance Abuse and Mental Health Services Administration (SAMHSA) Treatment Capacity Expansion Project...
August 22, 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/28829526/clinical-relevance-of-the-pharmacokinetic-characteristics-of-an-abuse-deterrent-extended-release-injection-molded-morphine-tablet
#8
Jeffrey M Dayno, Gwendolyn Niebler, John Lawler, Torben Elhauge, Karsten Lindhardt
OBJECTIVE: To characterize the pharmacokinetics (PK) and in vitro alcohol dissolution characteristics of extended-release (ER), injection-molded (IM) morphine tablets with abuse-deterrent (AD) features (morphine-ADER-IMT). DESIGN: In vivo, in vitro, and in silico studies were conducted. A randomized, two-cohort study evaluated the bioequivalence of morphine-ADER-IMT (60 mg) to morphine ER (60 mg; MS Contin®; Purdue Pharma LP, Stamford, CT) and characterized the effect of food on the PK profile of morphine-ADER-IMT...
March 2017: Journal of Opioid Management
https://www.readbyqxmd.com/read/28829522/opioid-pain-medication-prescriptions-obtained-through-emergency-medical-visits-in-the-veterans-health-administration
#9
Michael A Grasso, Zachary D W Dezman, Clare T Grasso, David A Jerrard
OBJECTIVE: This study sought to characterize national patterns for opioid pain medication (OPM) prescriptions received during emergency medical encounters in the Veterans Health Administration (VA). DESIGN: The authors conducted a retrospective study of all emergency department (ED) visits by adults in the VA between January 2009 and June 2015. We examined demographics, comorbidities, utilization measures, diagnoses, and prescriptions. MAIN OUTCOME MEASURES: The percentage of ED visits that culminated in the receipt of a prescription for an OPM...
March 2017: Journal of Opioid Management
https://www.readbyqxmd.com/read/28828867/guidelines-for-support-to-mothers-of-sexually-abused-children-in-north-west-province
#10
Gaboipolelwe M Masilo, Mashudu Davhana-Maselesele
BACKGROUND: South Africa is reported to have the highest rate of sexual assault in the world with over 40% of cases occurring among children. Children who are sexually abused have support programmes and policies to assist them in coping, but there are no support programmes for mothers or caretakers. Caretakers need support for themselves and assisting them will incrementally benefit children under their care. Often mothers of these children experience shock, anger, disbelief and suffer secondary trauma such as depression and post-traumatic stress disorder (PTSD) following their children's sexual abuse disclosure and yet there are no guidelines for support to these mothers within North-West province (NWP)Objectives: The study seeks to develop guidelines for support to mothers of sexually abused children in NWP...
July 25, 2017: Curationis
https://www.readbyqxmd.com/read/28828640/the-performance-of-3d-abus-versus-hhus-in-the-visualisation-and-bi-rads-characterisation-of-breast-lesions-in-a-large-cohort-of-1-886-women
#11
Athina Vourtsis, Aspasia Kachulis
OBJECTIVES: This study aimed to evaluate automated breast ultrasound (ABUS) compared to hand-held traditional ultrasound (HHUS) in the visualisation and BIRADS characterisation of breast lesions. MATERIALS AND METHODS: From January 2016 to January 2017, 1,886 women with breast density category C or D (aged 48.6±10.8 years) were recruited. All participants underwent ABUS and HHUS examination; a subcohort of 1,665 women also underwent a mammography. RESULTS: The overall agreement between HHUS and ABUS was 99...
August 21, 2017: European Radiology
https://www.readbyqxmd.com/read/28828202/the-benefits-of-community-and-juvenile-justice-involvement-in-organizational-research
#12
Carl G Leukefeld, Margaret Cawood, Tisha Wiley, Angela A Robertson, Jacqueline Horan Fisher, Nancy Arrigona, Patricia Donohue, Michelle Staples-Horne, Philip W Harris, Richard Dembo, Judy Roysden, Katherine R Marks
The Juvenile Justice (JJ) system has a number of local behavioral health service community linkages for substance abuse, mental health, and HIV services. However, there have only been a few systemic studies that examine and seek to improve these community behavioral health linkages for justice-involved youth. Implementation research is a way of identifying, testing, and understanding effective strategies for translating evidence-based treatment and prevention approaches into service delivery. This article explores benefits and challenges of participatory research within the context of the National Institute on Drug Abuse (NIDA)'s Juvenile Justice Translational Research on Interventions for Adolescents in the Legal System (JJ-TRIALS) implementation behavioral health study...
2017: Journal of Juvenile Justice
https://www.readbyqxmd.com/read/28828132/central-nervous-system-fungal-infection-in-a-young-male-with-a-history-of-intravenous-drug-abuse-and-hepatitis-c
#13
Celene Hadley, Atif Wasim Haneef Mohamed, Aparna Singhal
A young male, with a known history of hepatitis C and heroin abuse, was admitted to the emergency department with altered sensorium, left-sided weakness, and no meningeal signs. Initial computed tomography imaging showed hypodensity involving right basal ganglia with mass effect but no hemorrhage. Magnetic resonance imaging revealed multiple nonenhancing small foci of restricted diffusion involving the right basal ganglia, T2 and FLAIR hyperintensity within the right basal ganglia, and internal capsule with mild surrounding edema...
September 2017: Radiology case reports
https://www.readbyqxmd.com/read/28827940/assessment-of-private-homes-as-spaces-for-the-dying-elderly
#14
Tulika Bhattacharyya, Suhita Chopra Chatterjee, Dipannita Chand, Debolina Chatterjee, Jaydeep Sengupta
AIM: This study makes an assessment of end-of-life care of the elderly in private homes in Kolkata, West Bengal, India. PARTICIPANTS AND METHODS: Primary data were collected from private homes which supported elder care through observation and semi-structured interviews with primary family caregivers of the elderly. RESULTS: The study finds that the major factors preventing private homes from providing adequate care to the elderly were architecturally inadequate housing conditions, paucity of financial support, and scarcity of skilled caregivers...
July 2017: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/28827874/our-failure-to-protect-sexually-abused-children-where-is-our-willing-suspension-of-disbelief
#15
Sheila Ramaswamy, Shekhar Seshadri
No abstract text is available yet for this article.
April 2017: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28827868/silence-of-male-child-sexual-abuse-in-india-qualitative-analysis-of-barriers-for-seeking-psychiatric-help-in-a-multidisciplinary-unit-in-a-general-hospital
#16
Vyjayanthi Kanugodu Srinivasa Subramaniyan, Praveen Reddy, Girish Chandra, Chandrika Rao, T S Sathyanarayana Rao
INTRODUCTION: In 2007, Ministry of Women and Child Welfare, supported by United Nations Children's Fund, save the children and Prayas conducted a study to understand the magnitude of child abuse in India, they found that 53.22% children faced one or more forms of sexual abuse; among them, the number of boys abused was 52.94%. AIM: The aim of this study was to explore the barriers for seeking psychiatric help by qualitative analysis of stake holders of male victims of child abuse...
April 2017: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28827863/reasons-for-referral-and-diagnostic-concordance-between-physicians-surgeons-and-the-consultation-liaison-psychiatry-team-an-exploratory-study-from-a-tertiary-care-hospital-in-india
#17
Sandeep Grover, Swapnajeet Sahoo, Shivali Aggarwal, Shallu Dhiman, Subho Chakrabarti, Ajit Avasthi
BACKGROUND: Very few studies have evaluated the reasons for referral to consultation-liaison (CL) psychiatry teams. AIM: This study aimed to evaluate the psychiatric morbidity pattern, reasons for referral and diagnostic concordance between physicians/surgeons and the CL psychiatry team. MATERIALS AND METHODS: Two hundred and nineteen psychiatric referrals made to the CL psychiatry team were assessed for reason for referral and diagnostic concordance in terms of reason of referral and psychiatric diagnosis made by the CL psychiatry team...
April 2017: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28827245/association-of-workplace-and-population-characteristics-with-prevalence-of-hypertension-among-brazilian-industry-workers-a-multilevel-analysis
#18
Daniele B Vinholes, Sérgio L Bassanesi, Hilton de Castro Chaves Junior, Carlos Alberto Machado, Ione M F Melo, Flavio Danni Fuchs, Sandra Costa Fuchs
BACKGROUND: Exposure to risk factors for hypertension may be influenced by the characteristics of the workplace, where workers spend most of their daily time. OBJECTIVES: To evaluate the association between features of the companies, particularly the presence of facilities to provide meals, and of population characteristics and the prevalence of hypertension, taking into account individual risk factors for hypertension. MATERIAL AND METHODS: This multilevel analysis was based on a cross-sectional study with individual and company data from the SESI (Serviço Social da Indústria-Social Service of Industries) study and population-based data from the national census statistics...
August 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28827047/high-drinking-in-the-dark-hdid-mice-are-sensitive-to-the-effects-of-some-clinically-relevant-drugs-to-reduce-binge-like-drinking
#19
John C Crabbe, Angela R Ozburn, Pamela Metten, Amanda Barkley-Levenson, Jason P Schlumbohm, Stephanie E Spence, Wyatt R Hack, Lawrence C Huang
BACKGROUND: There is a serious public health need for better understanding of alcohol use disorder disease mechanisms and for improved treatments. At this writing, only three drugs are approved by the Food and Drug Administration as medications to treat alcohol use disorders - disulfiram, naltrexone, and acamprosate. Binge drinking is a form of abusive alcohol drinking defined by the NIAAA as a drinking to blood alcohol levels (BALs)>0.08% during a period of approximately 2h. To model genetic risk for binge-like drinking, we have used selective breeding to create a unique animal model, High Drinking in the Dark (HDID) mice...
August 4, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28826811/adverse-childhood-experiences-and-adult-abuse-are-predictors-of-hysterectomy-and-oophorectomy
#20
EDITORIAL
Liliana Gazzuola Rocca, Carin Y Smith, Elizabeth A Stewart, Walter A Rocca
No abstract text is available yet for this article.
August 3, 2017: Maturitas
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