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https://www.readbyqxmd.com/read/29677619/associations-of-early-childhood-adversities-with-mental-disorders-psychological-functioning-and-suitability-for-psychotherapy-in-adulthood
#1
Erkki Heinonen, Paul Knekt, Tommi Härkänen, Esa Virtala, Olavi Lindfors
Childhood adversities frequently precede adulthood depression and anxiety. Yet, how they impact needed treatment duration, type or focus in these common disorders, is unclear. For developing more individualized and precise interventions, we investigated whether specific early adversities associate with patients' distinct psychiatric problems, psychological vulnerabilities, and suitability for psychotherapy. A total of 221 depressed and anxious adult outpatients (excluding psychotic, severe personality, bipolar, and substance abuse disorders) referred from community, student, occupational, and private healthcare services filled the Childhood Family Atmosphere Questionnaire (CFAQ)...
April 4, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29677607/association-between-childhood-maltreatment-and-non-medical-prescription-opioid-use-among-chinese-senior-high-school-students-the-moderating-role-of-gender
#2
Yiling Lei, Chuhao Xi, Pengsheng Li, Min Luo, Wanxin Wang, Siyuan Pan, Xue Gao, Yan Xu, Guoliang Huang, Xueqing Deng, Lan Guo, Ciyong Lu
BACKGROUND: Non-medical prescription opioid use (NMPOU) and childhood maltreatment are currently serious problems among adolescents worldwide, and childhood maltreatment may be associated with the increased rates of NMPOU. This study examined the specific associations between particular types of childhood maltreatment and lifetime NMPOU and assessed whether gender has a moderating effect on these associations. METHODS: A 3-stage, stratified cluster, randomized sampling method was used to collect data from 11,194 high school students in Chongqing...
April 10, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29677591/lifestyle-factors-and-multiple-sclerosis-a-population-based-incident-case-control-study
#3
Ibrahim Abdollahpour, Saharnaz Nedjat, Mohammad Ali Mansournia, Mohammad Ali Sahraian, Ingrid van der Mei
OBJECTIVE: Although low sun exposure, low vitamin D, and smoking are established risk factor of multiple sclerosis (MS), there is less evidence on the role of the other lifestyle factors. We examined the association of sun exposure, physical activity, drug abuse, and alcohol intake with MS. MATERIALS AND METHODS: This was population-based incident case-control study in Iran with 547 incident cases and 1057 general population controls (7/8/2013-17/2/2015). Logistic regression was used to analyse the data...
March 31, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29677572/temperament-and-character-profiles-are-associated-with-depression-outcome-in-psychiatric-secondary-care-patients-with-harmful-drinking
#4
Vesa Paavonen, Kaisa Luoto, Antero Lassila, Esa Leinonen, Olli Kampman
BACKGROUND: Temperament and character profiles have been associated with depression outcome and alcohol abuse comorbidity in depressed patients. How harmful alcohol use modifies the effects of temperament and character on depression outcome is not well known. Knowledge of these associations could provide a method for enhancing more individualized treatment strategies for these patients. METHODS: We screened 242 depressed patients with at least moderate level of depressive symptoms...
April 7, 2018: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29677442/synthesis-and-pharmacological-evaluation-of-novel-c-8-substituted-tetrahydroquinolines-as-balanced-affinity-mu-delta-opioid-ligands-for-the-treatment-of-pain
#5
Anthony F Nastase, Nicholas W Griggs, Jessica P Anand, Thomas J Fernandez, Aubrie A Harland, Tyler J Trask, Emily M Jutkiewicz, John R Traynor, Henry I Mosberg
The use of opioids for the treatment of pain, while largely effective, is limited by detrimental side effects including analgesic tolerance, physical dependence, and euphoria, which may lead to opioid abuse. Studies have shown that compounds with a -opioid receptor (MOR) agonist/-opioid receptor (DOR) antagonist profile reduce or eliminate some of these side effects including development of tolerance and dependence. Herein we report the synthesis and pharmacological evaluation of a series of tetrahydroquinoline-based peptidomimetics with substitutions at the C-8 position...
April 20, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29677414/a-multistep-approach-to-address-clinican-knowledge-attitudes-and-behavior-around-opioid-prescribing
#6
Sara Kohlbeck, Brenna Akert, Caroline Pace, Amy Zosel
INTRODUCTION: The Wisconsin Prescription Drug Monitoring Program (PDMP) was implemented in 2013 to reduce the misuse, abuse, and diversion of controlled substance prescriptions. OBJECTIVE: To evaluate provider knowledge, attitudes, and behaviors regarding the Wisconsin PDMP before and after study interventions. METHODS: An initial survey of clinicians, a focus group, pre- and posttests for an educational session, and a 3-month follow-up survey were utilized...
March 2018: WMJ: Official Publication of the State Medical Society of Wisconsin
https://www.readbyqxmd.com/read/29677412/gunderkids-design-of-a-clinical-care-management-program-for-parents-with-substance-abuse-and-their-newborn-children-with-a-focus-on-preventing-child-abuse
#7
Ann E Budzak-Garza, Allison L Allmon Dixson, Renee A Holzer, Kaitlin E Lillard-Pierce, Carolynn J Devine
BACKGROUND: In response to an increased need to care for babies born to mothers with substance abuse issues, we developed GunderKids, a care management program that provides integrated medical care beyond standard-of-care, well-child appointments for these socially complex families. METHODS: The program incorporates frequent visits to the pediatrician and the care team, which includes pediatric nurses, a pediatric social worker, and a child psychologist. Enrollment is voluntary...
March 2018: WMJ: Official Publication of the State Medical Society of Wisconsin
https://www.readbyqxmd.com/read/29677410/mapping-drug-overdose-demographic-and-socioeconomic-characteristics-in-the-community
#8
Brenda L Rooney, Mitchell T Voter, Christopher M Eberlein, Andrea J Schossow, Cathy L Fischer
INTRODUCTION: Drug use and drug overdose have increased at an alarming rate. OBJECTIVE: To identify demographic and neighborhood social and economic factors associated with higher risk of overdose. These findings can be used to inform development of community programs and appropriately devote resources to prevent and treat drug abuse. METHODS: The electronic health records of all patients seen in the emergency department or admitted to the hospital for a drug overdose in 2016 at Gundersen Health System in La Crosse, Wisconsin, were reviewed retrospectively...
March 2018: WMJ: Official Publication of the State Medical Society of Wisconsin
https://www.readbyqxmd.com/read/29676839/analgesic-consumption-trajectories-in-8-975-patients-1-year-after-fast-track-total-hip-or-knee-arthroplasty
#9
C C Jørgensen, M Petersen, H Kehlet, E K Aasvang
BACKGROUND: Persistent or increased long-term opioid consumption has previously been described following total hip- (THA) and knee arthroplasty (TKA). However, detailed information on postoperative analgesic consumption trajectories and risk factors associated with continued need of analgesics in fast-track THA and TKA is sparse. METHODS: Descriptive multicenter study in primary unilateral fast-track THA or TKA with prospective data on patient characteristics and information on reimbursement entitled dispensed prescriptions of paracetamol, non-steroidal anti-inflammatory drugs, opioids, anticonvulsants, and antidepressants one month preoperatively and one year postoperatively...
April 20, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29676676/abusive-supervision-leader-member-exchange-and-moral-disengagement-a-moderated-mediation-model-of-organizational-deviance
#10
Matthew Valle, K Michele Kacmar, Suzanne Zivnuska, Troy Harting
This paper draws from social exchange theory and social cognitive theory to explore moral disengagement as a potential mediator of the relationship between abusive supervision and organizational deviance. We also explore the moderating effect of leader-member exchange (LMX) on this mediated relationship. Results indicate that employees with abusive supervisors engaged in moral disengagement strategies and subsequently in organizational deviance behaviors. Additionally, this relationship was stronger for those higher in LMX...
April 20, 2018: Journal of Social Psychology
https://www.readbyqxmd.com/read/29676586/data-sharing-platforms-for-de-identified-data-from-human-clinical-trials
#11
Vojtech Huser, Dikla Shmueli-Blumberg
Data sharing of de-identified individual participant data is being adopted by an increasing number of sponsors of human clinical trials. In addition to standardizing data syntax for shared trial data, semantic integration of various data elements is the focus of several initiatives that define research common data elements. This perspective article, in the first part, compares several data sharing platforms for de-identified clinical research data in terms of their size, policies and supported features. In the second part, we use a case study approach to describe in greater detail one data sharing platform (Data Share from National Institute of Drug Abuse)...
April 1, 2018: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/29676501/the-canary-in-the-coal-mine-continence-care-for-people-with-dementia-in-acute-hospital-wards-as-a-crisis-of-dehumanization
#12
Paula Boddington, Katie Featherstone
Continence is a key moment of care that can tell us about the wider care of people living with dementia within acute hospital wards. The spotlight is currently on the quality of hospital care of older people across the UK, yet concerns persist about their poor treatment, neglect, abuse, and discrimination within this setting. Thus, within hospitals, the care of people living with dementia is both a welfare issue and a human rights issue. The challenge of continence care for people living with dementia can be seen as the 'canary in the coal mine' for the unravelling of dignity within the acute setting...
May 2018: Bioethics
https://www.readbyqxmd.com/read/29676050/part-2-current-prescribing-trends-of-dental-non-antibacterial-medicines-in-australia-from-2013-to-2016
#13
L Teoh, K Stewart, R J Marino, M J McCullough
BACKGROUND: There is limited literature regarding dental prescribing preferences for medicines other than antibiotics. This study aimed to describe the prescribing trends of dispensed prescription medicines by dentists in Australia from 2013 and 2016 and assess adherence to current guidelines. METHODS: Data was accessed from the Department of Health of all dental prescriptions dispensed under the Pharmaceutical Benefits Scheme (PBS) from 2013 to 2016 and prescribing patterns were analysed...
April 19, 2018: Australian Dental Journal
https://www.readbyqxmd.com/read/29675707/a-rapid-solution-based-method-for-determining-the-affinity-of-heroin-hapten-induced-antibodies-to-heroin-its-metabolites-and-other-opioids
#14
Oscar B Torres, Alexander J Duval, Agnieszka Sulima, Joshua F G Antoline, Arthur E Jacobson, Kenner C Rice, Carl R Alving, Gary R Matyas
We describe for the first time a method that utilizes microscale thermophoresis (MST) technology to determine polyclonal antibody affinities to small molecules. Using a novel type of heterologous MST, we have accurately measured a solution-based binding affinity of serum antibodies to heroin which was previously impossible with other currently available methods. Moreover, this mismatch approach (i.e., using a cross-reactive hapten tracer) has never been reported in the literature. When compared with equilibrium dialysis combined with ultra-performance liquid chromatography/tandem mass spectrometry (ED-UPLC/MS/MS), this novel MST method yields similar binding affinity values for polyclonal antibodies to the major heroin metabolites 6-AM and morphine...
April 19, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29675071/pediatric-head-injury-a-study-of-403-cases-in-a-tertiary-care-hospital-in-a-developing-country
#15
Abrar Ahad Wani, Arif Hussain Sarmast, Muzaffar Ahangar, Nayil Khursheed Malik, Sarabjit Singh Chhibber, Sajad Hussain Arif, Altaf Umar Ramzan, Bashir Ahmed Dar, Zulfiqar Ali
Introduction: Traumatic brain injury (TBI) in children is a significant cause of morbidity and mortality worldwide. Falls are the most common type of injury, followed by motor vehicle-related accidents and child abuse. Aims and Objectives: The aim and objective of this study was to elucidate the various modes of injury, prognostic factors, complications, incidence of various modes of injury, and outcome in TBI in pediatric population. Materials and Methods: Patients with TBI, 18 years or less in age, managed in our Department of Neurosurgery, over a period of 2 years, were studied prospectively...
October 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29674802/dried-urine-spots-for-detection-of-benzodiazepines
#16
Raka Jain, Rizwana Quraishi, Atul Ambekar, Arpita Verma, Pratibha Gupta
BACKGROUND AND AIM: Benzodiazepines (BZD) are widely prescribed to substance users. However, the nonmedical use of prescription BZD often leads to abuse and dependence. Therefore, it is important to detect BZD among substance users seeking treatment. The aim of the present study was to develop an efficient method for testing BZD on dried urine spot (DUS) and evaluating its clinical applicability. METHODS: This involved optimization of conditions for the detection, recovery, and stability of BZD from dried urine, spotted on filter paper...
November 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29674776/-anxiety-depression-and-risk-consumption-of-alcohol-in-a-sample-of-university-students
#17
Omar Enzo Santangelo, Sandro Provenzano, Alberto Firenze
AIM: The university student is vulnerable to the adverse effects of many stress factors that can lead to depressive symptoms, anxiety and alcohol abuse, causing an increase in the burden of illness in young people. The aim of the study was to measure depressive symptoms, anxiety levels, and harmful alcohol consumption within the student population of the University of Palermo. METHODS: An online questionnaire was sent by e-mail to the 8500 students enrolled in the (ERSU) Regional Office for the Right to University Study's mailing list in Palermo...
March 2018: Rivista di Psichiatria
https://www.readbyqxmd.com/read/29674401/licorice-induced-apparent-mineralocorticoid-excess-compounded-by-excessive-use-of-terbutaline-and-high-water-intake
#18
Laust Frisenberg Buhl, Frederik Nørregaard Pedersen, Marianne Skovsager Andersen, Dorte Glintborg
This case highlights the clinical course of a 54-year-old male patient presenting with hypertension and long-term refractory hypokalaemia. He reported long-term malaise, fatigue and physical discomfort. Diarrhoea, vomiting, over-the-counter drugs, dietary supplements and any kind of medical abuse were all denied. Physical examination was normal. Suppressed plasma renin activity along with a low aldosterone level and elevated urinary cortisone/cortisol metabolite excretion ratio raised the suspicion of apparent mineralocorticoid excess (AME)...
April 19, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29673827/menopause-ageing-and-alcohol-use-disorders-in-women
#19
REVIEW
Jelena Milic, Marija Glisic, Trudy Voortman, Laura Pletsch Borba, Eralda Asllanaj, Lyda Z Rojas, Jenna Troup, Jessica C Kiefte-de Jong, Ed van Beeck, Taulant Muka, Oscar H Franco
Alcohol intake affects the female body differently than it affects the male body. This is caused by females' lower levels of dehydrogenase enzymes, the enzyme that breaks down alcohol, coupled with the higher fat/water ratio of the female body. Both these factors cause alcohol levels to rise more quickly after ingestion in women than in men. This makes females more vulnerable to alcohol's harmful effects, and consequently women tend to develop alcohol-related diseases earlier in life than do men. As women age and go through menopause, they experience changes in body composition and life changes like retirement or loss of a loved one...
May 2018: Maturitas
https://www.readbyqxmd.com/read/29673737/epidemiological-features-of-cancers-of-the-oral-cavity-oropharynx-hypopharynx-and-larynx-cancer-in-r%C3%A3-union-island
#20
A Delagranda, G Leterme, E Chirpaz, C Ferdynus, C Fernandez, F Rubin
INTRODUCTION: This study had two objectives: firstly, to identify and compare characteristics of cancer of the oral cavity, oropharynx, hypopharynx and larynx in Réunion Island, a tropical French overseas territory in the southern hemisphere; and secondly, to discuss how incidence of these cancers is presented in the international literature. MATERIAL AND METHOD: A retrospective study included 599 patients diagnosed with cancer of the oral cavity, oropharynx, hypopharynx or larynx between 2009 and 2013 in Réunion Island...
April 16, 2018: European Annals of Otorhinolaryngology, Head and Neck Diseases
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