keyword
MENU ▼
Read by QxMD icon Read
search

Abuse

keyword
https://www.readbyqxmd.com/read/28441487/the-isomeric-preference-of-an-atypical-dopamine-transporter-inhibitor-contributes-to-its-selection-of-the-transporter-conformation
#1
Ara M Abramyan, Sebastian Stolzenberg, Zheng Li, Claus J Loland, Frank Noé, Lei Shi
Cocaine, a widely abused psychostimulant, inhibits the dopamine transporter (DAT) by trapping the protein in an outward-open conformation, whereas atypical DAT inhibitors such as benztropine have low abuse liability and prefer less outward-open conformations. Here, we use a spectrum of computational modeling and simulation approaches to obtain the underlying molecular mechanism in atomistic detail. Interestingly, our quantum mechanical calculations and molecular dynamics (MD) simulations suggest that a benztropine derivative JHW007 prefers a different stereoisomeric conformation of tropane in binding to DAT compared to that of a cocaine derivative, CFT...
April 25, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28441274/-meth-mouth-an-interdisciplinary-review-of-a-dental-and-psychiatric-condition
#2
Cornel N Stanciu, Magdalena Glass, Brian C Muzyka, Oliver M Glass
OBJECTIVE: Chronic methamphetamine (MA) users experience many dental problems, a condition characterized as "meth mouth." These devastating effects on dentition is the main reason why many seek professional help. Here, we discuss the effects of MA on oral health and advocate for improved collaboration between dentists and mental health providers. We also introduce a dental evaluation tool with the goal of improving the quality of care for this often-marginalized patient population. METHODS: A Medline literature search (1985-2016) was conducted with keywords "meth mouth," "methamphetamine AND oral health"; "methamphetamine AND dental"; "methamphetamine AND dentist...
April 24, 2017: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/28441203/the-pervasive-culture-of-abuse-in-medical-education-a-focus-on-developing-countries
#3
Justin Z Amarin, Saif M Borgan
No abstract text is available yet for this article.
May 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28441113/research-with-american-indian-and-alaska-native-populations-measurement-matters
#4
Melissa L Walls, Nancy Rumbaugh Whitesell, Allison Barlow, Michelle Sarche
Research is an important tool in addressing myriad American Indian and Alaska Native (AIAN) health disparities; however, tensions exist between common empirical measurement approaches that facilitate cross-cultural comparisons and measurement specificity that may be more valid locally and/or culturally appropriate. The tremendous diversity of AIAN communities, small population sizes of distinct AIAN cultural groups, and varying cultural contexts and worldviews should influence measurement decisions in health research...
April 25, 2017: Journal of Ethnicity in Substance Abuse
https://www.readbyqxmd.com/read/28441103/perceptions-of-abusive-parenting-behaviors-a-preliminary-exploration-into-the-underrecognition-of-mother-daughter-sexual-abuse
#5
Christine J Hatchard, Jamie L Goodwin, Eryn Siddall, Lauren Muniz
The current study examined the influence of the sex of the parent and the sex of the child on perceptions of sexually abusive behaviors. Vignettes illustrating different forms of sexual abuse were rated by 124 participants, with the different parent-child pairs (mother-daughter, mother-son, father-daughter, father-son) substituted into the vignettes being the only difference between groups. Two-way between subjects ANOVAs revealed that sexually abusive behaviors by mothers were perceived as less damaging to child victims (F (1, 120 = 7...
April 25, 2017: Journal of Child Sexual Abuse
https://www.readbyqxmd.com/read/28441096/judicial-decision-making-and-juvenile-offenders-effects-of-medical-evidence-and-victim-age
#6
John Michael Falligant, Rebecca L Fix, Apryl A Alexander
A growing body of evidence suggests that jurors place greater weight on DNA or other types of forensic evidence than non-forensic evidence (Cole & Dioso-Villa, 2009). For cases involving child sexual abuse, certain types of evidence, including forensic medical evidence, may be viewed as more important or indicative of abuse than other types of evidence, such as victim statements or disclosure. The present study evaluated perceptions of juvenile offenders and victim credibility across four vignettes that systematically manipulated variables related to victim age and physical indicators of abuse...
April 25, 2017: Journal of Child Sexual Abuse
https://www.readbyqxmd.com/read/28440693/maternal-history-of-child-abuse-and-obesity-risk-in-offspring-mediation-by-weight-in-pregnancy
#7
Stephanie A Leonard, Lucia C Petito, David H Rehkopf, Lorrene D Ritchie, Barbara Abrams
BACKGROUND: Women's experience of childhood adversity may contribute to their children's risk of obesity. Possible causal pathways include higher maternal weight and gestational weight gain, which have been associated with both maternal childhood adversity and obesity in offspring. METHODS: This study included 6718 mother-child pairs from the National Longitudinal Survey of Youth 1979 in the United States (1979-2012). We applied multiple log-binomial regression models to estimate associations between three markers of childhood adversity (physical abuse, household alcoholism, and household mental illness) and offspring obesity in childhood...
April 25, 2017: Childhood Obesity
https://www.readbyqxmd.com/read/28440194/concurrent-use-of-cannabis-and-alcohol-neuropsychiatric-effects-and-consequences
#8
Anna Romaguera, Marta Torrens, Esther Papaseit, Ana Lucia Arellano, Magi Farré
Concurrent use of cannabis and alcohol is frequent. According different studies, the prevalence is among 20-34% depending on different samples studied. In contrast with the wide evidence available about neuropsychiatric effects associated to the use of cannabis or alcohol separately, there are few studies of the neuropsychiatric effects of their combination. Our aim was to review the literature regarding this topic. We performed a search in MEDLINE and from 114 potentially eligible studies, 27 were selected...
April 19, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28440191/cannabis-a-neurological-remedy-or-a-drug-of-abuse-in-india
#9
Pronit Biswas, Pooja Mishra, Devasish Bose, Abhilasha Durgbanshi
Since ancient times it is well documented the use of cannabis as a medicine due to its potential therapeutic activity while subsequently its use as drug of abuse spread increasingly. The present review sought to give an insight in the history of medical and recreational use of cannabis in India. Indian use of cannabis dates back to Vedic time, mostly for the ritualistic and religious purposed, as documented in the ancient literature. It was India that introduced the medical use of cannabis to neighboring countries...
April 23, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28440070/chiral-analysis-of-amphetamines-in-hair-by-liquid-chromatography-tandem-mass-spectrometry-compliance-monitoring-of-attention-deficit-hyperactivity-disorder-adhd-patients-under-elvanse%C3%A2-therapy-and-identification-after-controlled-low-dose-application
#10
Tina M Binz, Elena Williner, Petra Strajhar, Patrick C Dolder, Matthias E Liechti, Markus R Baumgartner, Thomas Kraemer, Andrea E Steuer
Amphetamine (AMP) is used as illicit drug but also for the treatment of attention deficit hyperactivity disorder (ADHD). Respective drugs most often contain the enantiomer (S)-AMP as active compound or (S)-AMP is formed from the prodrug lisdexamfetamine (Elvanse®) whereas the illicit drug is usually traded as racemate ((R/S)-AMP). A differentiation between the use of the medically prescribed drug and the abuse of illicit street amphetamine is of great importance e.g. in retrospective consumption monitoring by hair analysis...
April 24, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28439943/botryoid-nuclei-resulting-from-cocaine-abuse
#11
Maurizio Fumi, Ylenia Pancione, Silvia Sale, Vincenzo Rocco, Barbara J Bain
No abstract text is available yet for this article.
April 25, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28439756/psychological-distress-among-methadone-maintenance-patients-in-vietnamese-mountainous-areas
#12
Long Hoang Nguyen, Bach Xuan Tran, Huong Lan Thi Nguyen, Cuong Tat Nguyen, Canh Dinh Hoang, Hai Quan Le, Hung Van Nguyen, Huong Thi Le, Tho Dinh Tran, Carl A Latkin, Thuc Minh Thi Vu
We conducted a cross-sectional study in Tuyen Quang Province, a mountainous province in northern Vietnam, to examine rates of psychological distress among 241 patients receiving methadone maintenance treatment (MMT). Using the Kessler psychological distress Scale, we found that approximately one-fourth (26.8%) of respondents suffered from mental health pathologies. Physical health problems, current drug use, and alcohol abuse were found to be associated with mental health problems among the participants. Our findings highlight the high prevalence of psychological distress among MMT patients in northern Vietnam, and the need to integrate mental and physical health care services, as well as behavioral health counseling, into currently existing MMT clinics in this region...
April 24, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28439601/collapsing-glomerulopathy-the-saudi-arabian-scenario-a-study-of-31-cases-and-a-review-of-literature
#13
Sufia Husain
To compare the clinico-pathological features of collapsing glomerulopathy (CG) at a tertiary hospital in Saudi Arabia with the world literature. Methods: In a retrospective study, all biopsy-diagnosed cases of CG between 2004-2015 were identified and analyzed, at King Khalid University Hospital, King Saud University, Riyadh. The clinico-pathological findings along with prognosis were reviewed and compared with the reported literature.  Results: Thirty-one CG patients were identified, most were adult males...
May 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28439304/is-percutaneous-medial-hamstring-myofascial-lengthening-as-anatomically-effective-and-safe-as-the-open-procedure
#14
T Mansour, J Derienne, M Daher, D Sarraf, Y Zoghbi, I Ghanem
BACKGROUND: Medial hamstring fractional lengthening is commonly performed in children with cerebral palsy (CP) to decrease contracture and/or to improve gait. Percutaneous procedures are gaining more and more popularity, even in the paediatric population, with equivocal results. The purpose of this paper was to determine the efficacy and safety of percutaneous medial hamstring myofascial lengthening (PHL). METHODS: This is a prospective randomised controlled trial including 31 knees from 18 consecutive patients with CP scheduled for medial hamstring lengthening in the setting of multilevel tendon lengthening procedures in a university hospital...
2017: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/28439100/ventral-striatal-regulation-of-crem-mediates-impulsive-action-and-drug-addiction-vulnerability
#15
M L Miller, Y Ren, H Szutorisz, N A Warren, C Tessereau, G Egervari, A Mlodnicka, M Kapoor, B Chaarani, C V Morris, G Schumann, H Garavan, A M Goate, M J Bannon, J M Halperin, Y L Hurd
Impulsivity, a multifaceted behavioral hallmark of attention-deficit/hyperactivity disorder (ADHD), strongly influences addiction vulnerability and other psychiatric disorders that incur enormous medical and societal burdens yet the neurobiological underpinnings linking impulsivity to disease remain poorly understood. Here we report the critical role of ventral striatal cAMP-response element modulator (CREM) in mediating impulsivity relevant to drug abuse vulnerability. Using an ADHD rat model, we demonstrate that impulsive animals are neurochemically and behaviorally more sensitive to heroin and exhibit reduced Crem expression in the nucleus accumbens core...
April 25, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28438987/major-trauma-from-suspected-child-abuse-a-profile-of-the-patient-pathway
#16
Ffion C Davies, Fiona E Lecky, Ross Fisher, Marisol Fragoso-Iiguez, Tim J Coats
BACKGROUND: Networked organised systems of care for patients with major trauma now exist in many countries, designed around the needs of the majority of patients (90% adults). Non-accidental injury is a significant cause of paediatric major trauma and has a different injury and age profile from accidental injury (AI). This paper compares the prehospital and inhospital phases of the patient pathway for children with suspected abuse, with those accidentally injured. METHODS: The paediatric database of the national trauma registry of England and Wales, Trauma Audit and Research Network, was interrogated from April 2012 (the launch of the major trauma networks) to June 2015, comparing the patient pathway for cases of suspected child abuse (SCA) with AI...
April 24, 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28438777/preference-for-an-opioid-benzodiazepine-mixture-over-an-opioid-alone-using-a-concurrent-choice-procedure-in-rhesus-monkeys
#17
Peter F Weed, Charles P France, Lisa R Gerak
Increased opioid abuse is contributing to a dramatic rise in overdose deaths. Benzodiazepines are frequently coabused with opioids, possibly because they increase the potency and/or effectiveness of opioids. This study used a concurrent choice procedure to determine whether monkeys would choose to self-administer a mixture of the opioid remifentanil and the benzodiazepine midazolam over remifentanil alone. Initially, three monkeys could respond on one lever for saline and on a second lever for either remifentanil alone or midazolam alone...
April 24, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28438100/an-epidemiology-of-sexual-assault-among-elderly-women-in-the-mthatha-area-of-south-africa
#18
Banwari L Meel
Background South Africa has one of the highest rates of rape in the world, but this barely seems to surprise anyone. It is extremely disturbing, especially when children and elderly women are raped. Women and children are usually the weakest group in society physically, as well as the most exposed to abuse and neglect. It should be the responsibility of a civil society to protect these vulnerable groups from harm. Objective This study investigated the trend of rapes among elderly women in the Mthatha area of South Africa...
April 2017: Medicine, Science, and the Law
https://www.readbyqxmd.com/read/28437722/effective-active-vaccination-against-methamphetamine-in-female-rats
#19
J D Nguyen, P T Bremer, C S Hwang, S A Vandewater, K C Collins, K M Creehan, K D Janda, M A Taffe
BACKGROUND: Immunotherapies directed against methamphetamine (MA) abuse have shown success in rodent models, however only a limited number of studies have investigated active vaccination in female mice and none in female rats. It is critical to determine if potential immunotherapeutic strategies generalize across sex, particularly for drugs that may produce significant sex-differences on behavioral or physiological endpoints. METHODS: Female Wistar rats were initially vaccinated with keyhole-limpet hemocyanin (KLH) or an anti-methamphetamine-KLH conjugate (MH6-KLH) three times over five weeks and implanted with radiotelemetry devices to assess locomotor activity and body temperature responses to MA...
April 14, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28437023/authors-overarching-reply-to-all-the-responses-received-to-the-systematic-literature-review-on-shaken-baby-syndrome
#20
Niels Lynøe, Göran Elinder, Boubou Hallberg, Måns Rosén, Pia Sundgren, Anders Eriksson
There have been a lot of views expressed about our paper on shaken baby syndrome, which was published in Acta Paediatrica (1). We acknowledge the concerns expressed by all of the authors who responded with regard to child welfare and the possibility that the diagnoses may be delayed in individual cases of child abuse. However, we are very troubled by the disregard displayed by those authors to the significant methodological problems inherent in published research on shaken baby syndrome. This article is protected by copyright...
April 24, 2017: Acta Paediatrica
keyword
keyword
5952
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"