keyword
MENU ▼
Read by QxMD icon Read
search

Abuse

keyword
https://www.readbyqxmd.com/read/29458056/alcohol-and-cv-health-jekyll-and-hyde-j-curves
#1
REVIEW
Evan L O'Keefe, James J Di Nicolantonio, James H O'Keefe, Carl J Lavie
A routine of light or moderate alcohol consumption (≤1 drink/day for women and 1 to 2 drinks/day for men) were associated with a lower risk for all-cause mortality, coronary artery disease (CAD), type 2 diabetes mellitus (T2D), heart failure (HF), and stroke. Conversely, heavy drinking, (>4 drinks/day) is associated with an increased risk for death and cardiovascular (CV) disease (CVD). Excessive alcohol intake trails behind only smoking and obesity among the 3 leading causes of premature deaths in the United States (US)...
February 16, 2018: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29457668/the-relationships-between-depression-neuroticism-and-attitudes-nda-model-in-heroin-abusers-in-taiwan
#2
Kun-Hua Lee, Cheng-Fang Yen
BACKGROUND AND OBJECTIVES: Heroin use is a severe problem worldwide. To develop more effective treatments for heroin abusers, a comprehensive psychosocial model of heroin use should be established and examined. We created and assessed a neuroticism, depression, attitudes, and heroin addiction (NDA) model. METHODS: In this cross-sectional study, 234 patients undergoing methadone replacement treatment were recruited from psychiatric clinics. We used Structural Equation Modeling (SEM) to assess all for neuroticism, depression, and a positive outcome expectancy (POE) (attitudes)...
February 19, 2018: American Journal on Addictions
https://www.readbyqxmd.com/read/29457656/fatty-acid-binding-protein-deletion-prevents-stress-induced-preference-for-cocaine-and-dampens-stress-induced-corticosterone-levels
#3
John Hamilton, Matthew Marion, Antonio Figueiredo, Brendan H Clavin, Dale Deutsch, Martin Kaczocha, Samir Haj-Dahmane, Panayotis K Thanos
Genetic and pharmacological manipulation of endocannabinoid (eCB) signaling has previously been shown to have an important role on the rewarding properties of drugs of abuse, including cocaine. Recently, fatty acid binding proteins (FABPs) have been proposed as intracellular transporters of the endocannabinoid anandamide (AEA) as well as other bioactive lipids to their catabolic enzyme, fatty acid amide hydrolase (FAAH). The role of these transporters in modulating the brains reward system has yet to be investigated...
February 19, 2018: Synapse
https://www.readbyqxmd.com/read/29457219/smokin-hot-adolescent-smoking-and-the-risk-of-psychosis
#4
A Mustonen, T Ahokas, T Nordström, G K Murray, P Mäki, E Jääskeläinen, A Heiskala, J J Mcgrath, J G Scott, J Miettunen, S Niemelä
OBJECTIVE: Daily smoking has been associated with a greater risk of psychosis. However, we are still lacking studies to adjust for baseline psychotic experiences and other substance use. We examined associations between daily smoking and psychosis risk in a 15-year follow-up while accounting for these covariates in a prospective sample (N = 6081) from the Northern Finland Birth Cohort 1986. METHODS: Self-report questionnaires on psychotic experiences (PROD-screen), tobacco smoking and other substance use were completed when the cohort members were 15-16 years old...
February 18, 2018: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29456938/deep-neck-space-infections-a-study-in-diabetic-population-in-a-tertiary-care-centre
#5
Kalpana Sharma, Devjani Das, Manish Joshi, Dipjyoti Barman, A J Sarma
This study is intended to analyze the clinical profile and outcomes of deep neck space infection in diabetic patients in our tertiary care centre. A prospective study of 1 year duration from 30th September 2015 to 30th September 2016 at department of Otorhinolaryngology, Gauhati Medical College and Hospital, Guwahati. A total of 45 diabetic patients who presented with DNSI are included in this study. Their demographic profile, etiology, bacteriology, treatment, duration of hospital stay, complications and outcomes have been analyzed...
March 2018: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/29456493/administration-of-ketamine-causes-autophagy-and-apoptosis-in-the-rat-fetal-hippocampus-and-in-pc12-cells
#6
Xinran Li, Yanan Li, Jinghua Zhao, Lina Li, Yuxin Wang, Yiming Zhang, Yue Li, Yu Chen, Wenhan Liu, Li Gao
Drug abuse during pregnancy is a serious problem. Like alcohol, anticonvulsants, sedatives, and anesthetics, such as ketamine, can pass through the placental barrier and affect the growing fetus. However, the mechanism by which ketamine causes damage to fetal rats is not well understood. Therefore, in this study, we anesthetized pregnant rats with ketamine and evaluated the Total Antioxidant Capacity (T-AOC), Reactive Oxygen Species (ROS), and Malondialdehyde (MDA). Moreover, we determined changes in the levels of Cleaved-Caspase-3 (C-Caspase-3), Beclin-1, B-cell lymphoma-2 (Bcl-2), Bcl-2 Associated X Protein (Bax), Autophagy-related gene 4 (Atg4), Atg5, p62 (SQSTM1), and marker of autophagy Light Chain 3 (LC3)...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29456463/income-and-child-maltreatment-in-unmarried-families-evidence-from-the-earned-income-tax-credit
#7
Lawrence M Berger, Sarah A Font, Kristen S Slack, Jane Waldfogel
This study estimates the associations of income with both (self-reported) child protective services (CPS) involvement and parenting behaviors that proxy for child abuse and neglect risk among unmarried families. Our primary strategy follows the instrumental variables (IV) approach employed by Dahl and Lochner (2012), which leverages variation between states and over time in the generosity of the total state and federal Earned Income Tax Credit for which a family is eligible to identify exogenous variation in family income...
December 2017: Review of Economics of the Household
https://www.readbyqxmd.com/read/29455628/ng%C3%A4-whak%C3%A4-whitinga-standing-at-the-crossroads-how-m%C3%A4-ori-understand-what-western-psychiatry-calls-schizophrenia
#8
Melissa Taitimu, John Read, Tracey McIntosh
This project explored how Māori understand experiences commonly labelled "schizophrenic" or "psychotic". Semi-structured interviews were conducted with 57 Māori participants who had either personal experiences labelled as "psychosis" or "schizophrenia", or who work with people with such experiences; including tangata whaiora (users of mental health services), tohunga (traditional healers), kaumatua/kuia (elders), Māori clinicians, cultural support workers and students...
January 1, 2018: Transcultural Psychiatry
https://www.readbyqxmd.com/read/29455270/ventricular-tachycardia-triggered-by-loperamide-and-famotidine-abuse
#9
Timothy R Larsen, Jedediah McMunn, Hala Ahmad, Soufian T AlMahameed
A 32-year-old male developed recurrent ventricular tachycardia after taking mega doses of loperamide and famotidine in order to experience an opiate-like euphoric effect. He was taking up to 200 mg of loperamide and multiple doses of famotidine each day. He developed palpitations and syncope. Electrocardiography demonstrated ventricular tachycardia and QT interval prolongation (corrected QT interval was 597 ms). He was diagnosed with loperamide-induced QT prolongation resulting in incessant ventricular tachycardia...
February 17, 2018: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/29455170/comparison-and-validation-of-screening-tools-for-substance-use-in-pregnancy-a-cross-sectional-study-conducted-in-maryland-prenatal-clinics
#10
Victoria H Coleman-Cowger, Emmanuel A Oga, Erica N Peters, Kathleen Trocin, Bartosz Koszowski, Katrina Mark
INTRODUCTION: Prescription-drug use in the USA has increased by more than 60% in the last three decades. Prevalence of prescription-drug use among pregnant women is currently estimated around 50%. Prevalence of illicit drug use in the USA is 14.6% among pregnant adolescents, 8.6% among pregnant young adults and 3.2% among pregnant adults. The first step in identifying problematic drug use during pregnancy is screening; however, no specific substance-use screener has been universally recommended for use with pregnant women to identify illicit or prescription-drug use...
February 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29455144/evaluation-of-childhood-trauma-with-respect-to-criminal-behavior-dissociative-experiences-adverse-family-experiences-and-psychiatric-backgrounds-among-prison-inmates
#11
Merih Altintas, Mustafa Bilici
OBJECTIVE: To evaluate childhood trauma in relation to criminal behavior, dissociative experiences, adverse family experiences during childhood and psychiatric backgrounds among prison inmates. METHODS: In total, 200 prison inmates were included in this questionnaire-based study. Data on demographic characteristics, adverse family experiences during childhood and psychiatric backgrounds were collected via face-to-face interviews, and a psychometric evaluation was conducted using the Childhood Trauma Questionnaire (CTQ-28) and Dissociative Experiences Scale (DES)...
January 2, 2018: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29454841/hypocretin-orexin-deficiency-decreases-cocaine-abuse-liability
#12
Nadia Steiner, Clara Rossetti, Takeshi Sakurai, Masashi Yanagisawa, Luis de Lecea, Pierre J Magistretti, Olivier Halfon, Benjamin Boutrel
Compelling evidence indicates that hypocretin/orexin signaling regulates arousal, stress and reward-seeking behaviors. However, most studies on drug reward-related processes have so far described the effects of pharmacological blockers disrupting hypocretin/orexin transmission. We report here an extensive study on cocaine-related behaviors in hypocretin/orexin-deficient mice (KO) and their heterozygous (HET) and wildtype (WT) littermates. We evaluated behavioral sensitization following repeated administrations and preference for an environment repeatedly paired with cocaine injections (15 mg/kg)...
February 15, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29454475/does-childhood-neglect-contribute-to-violent-behavior-in-adulthood-a-review-of-possible-links
#13
REVIEW
Vikki J Bland, Ian Lambie, Charlotte Best
Child neglect, whether intentional or unintentional on the part of caregivers, has serious and far-reaching negative consequences for children. Neglect is the most prevalent form of child maltreatment and has been associated with impaired cognitive development, changes in brain structure and nervous systems, behavioral and personality disorders and poor academic performance. However, the role of child neglect, and subtypes of neglect, in the development of adult violent behavior is not well understood. The "cycle of violence" hypothesis, which predicts that individuals exposed to child physical abuse are more likely to be physically violent in adulthood, is well supported by the literature...
February 9, 2018: Clinical Psychology Review
https://www.readbyqxmd.com/read/29454258/the-role-of-dissociation-in-revictimization-across-the-lifespan-a-32-year-prospective-study
#14
Osnat Zamir, Ohad Szepsenwol, Michelle M Englund, Jeffry A Simpson
Exposure to childhood abuse puts women at risk for revictimization in adult intimate relationships, but knowledge about the mechanism by which it occurs is limited. The present study investigated whether dissociation mediates the effect of exposure to physical or sexual child abuse on intimate partner violence in adulthood. We tested this using prospective data collected from birth to age 32 from 80 female participants in the Minnesota Longitudinal Study of Risk and Adaptation. We found that women who experienced sexual or physical abuse during the first 17...
February 14, 2018: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29454241/frailty-and-life-course-violence-the-international-mobility-in-aging-study
#15
Cristiano Dos Santos Gomes, Catherine McLean Pirkle, Maria Vitoria Zunzunegui, Dimitri Taurino Guedes, Juliana Fernandes De Souza Barbosa, Phoebe Hwang, Ricardo Oliveira Guerra
OBJECTIVE: To estimate the prevalence of frailty in older adults in the IMIAS population, to examine associations between lifelong domestic violence and frailty and possible pathways to explain these associations. METHODS: A cross-sectional study with 2002 men and women in the International Mobility in Aging Study, aged between 65 and 74 years old living in five cities of Tirana (Albania), Natal (Brazil), Kingston and Saint-Hyacinthe (Canada), and Manizales (Colombia)...
February 8, 2018: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29454220/early-life-sexual-abuse-is-associated-with-increased-suicide-attempts-an-update-meta-analysis
#16
REVIEW
Qin Xiang Ng, Bob Zheng Jie Yong, Collin Yin Xian Ho, Donovan Yutong Lim, Wee-Song Yeo
Suicide is an emerging, yet preventable global health issue associated with significant mortality. Identification of underlying risk factors and antecedents may inform preventive strategies and interventions. This study serves to provide an updated meta-analysis examining the extent of association of early life sexual abuse with suicide attempts. Using the keywords [early abuse OR childhood abuse OR sexual OR rape OR molest* OR violence OR trauma OR PTSD] AND [suicid* OR premature OR unnatural OR deceased OR died OR mortality], a preliminary search on the PubMed, Ovid, PsychINFO, Web of Science and Google Scholar databases yielded 12,874 papers published in English between 1-Jan-1988 and 1-June-2017...
February 6, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29453941/increased-morbidity-and-mortality-associated-with-falls-among-patients-with-cirrhosis
#17
Ghideon Ezaz, Susan L Murphy, Jessica Mellinger, Elliot B Tapper
BACKGROUND: Injuries are more morbid and complicated to manage in patients with cirrhosis. However, data are limited regarding the relative risk of injury and severity of injury from falls in patients with cirrhosis compared to those without cirrhosis. METHODS: We examined the nationally representative National Emergency Department Sample, an all-payer database including all patients presenting with falls 2009-2012. We determined the relative risks for and clinical associations with severe injuries...
February 14, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29453868/coexistent-solid-malignancies-in-pemphigus-a-population-based-study
#18
Khalaf Kridin, Shira Zelber-Sagi, Doron Comaneshter, Arnon D Cohen
Importance: The association of pemphigus vulgaris and pemphigus foliaceus with comorbid malignancies is yet to be firmly established. Objective: To estimate the association between pemphigus and a wide range of nonhematologic malignancies using one of the largest cohorts of patients with pemphigus to date. Design, Setting, and Participants: For this cross-sectional study, we used the computerized database of Clalit Health Services, the largest public health care provider organization in Israel insuring 4...
February 16, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29453031/spaces-of-hope-youth-perspectives-on-health-and-wellness-in-indigenous-communities
#19
Lydia Wood, David Kamper, Kate Swanson
This article addresses an apparent paradox between academic and policy depictions of American Indian reservations as "broken" and "unhealthy" places, and Indigenous youth perceptions of reservations as spaces of "health" and "wellness." Public health literature often frames reservations as damaged, health-denying places, chronicling the extraordinarily high rates of suicide, substance abuse, as well as vast health disparities. Despite these dire statistics, our research with Native youth in San Diego County found that young people chose to primarily emphasize their positive experiences with, and attachments to, their reservations...
February 13, 2018: Health & Place
https://www.readbyqxmd.com/read/29453024/simultaneous-determination-of-ibuprofen-and-its-metabolites-in-complex-equine-urine-matrices-by-gc-ei-ms-in-excretion-study-in-view-of-doping-control
#20
Emilia Waraksa, Marzena Wójtowicz-Zawadka, Dorota Kwiatkowska, Anna Jarek, Anna Małkowska, Robert Wrzesień, Jacek Namieśnik
A novel assay for the simultaneous determination of ibuprofen (IBU) and its four probable metabolites, 1-hydroxyibuprofen (1-OH IBU), 2-hydroxyibuprofen (2-OH IBU), 3-hydroxyibuprofen (3-OH IBU) and carboxyibuprofen (CBX IBU) in equine urine samples with the application of Gas Chromatography-Electron Ionization-Mass Spectrometry (GC-EI-MS) has been developed and elaborated. The new approach for sample preparation including minimizing matrix effects by the application of weak cation exchange solid-phase extraction together with strong cation exchange solid-phase extraction has been applied...
February 5, 2018: Journal of Pharmaceutical and Biomedical Analysis
keyword
keyword
5952
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"