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Omentum, ovarian cancer

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https://www.readbyqxmd.com/read/27857266/my-personal-journey-with-ovarian-cancer-treatment-caring-and-chemotherapy-tips
#1
Kim A Decker
Six years ago, I was diagnosed with stage IIIA ovarian low malignant cell potential cancer. It was the most shocking situation I have ever experienced. I didn't realize I had any symptoms, except occasional back pain, which I attributed to starting a new workout program. I had scheduled an abdominal computerized tomography (CT) scan for recurrent microscopic hematuria, which my internist wanted to check. I was told I would hear the results in two days. Two hours after my CT scan, while I was eating ice cream and watching television, an on-call genitourinary doctor (who I did not personally know) called to tell me the good news-that I had kidney stones, thus the microscopic hematuria...
December 1, 2016: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/27819640/mature-teratoma-associated-with-bilateral-ovarian-carcinosarcoma-accidental-association-or-etiopathogenetic-determinism-case-report
#2
Rodica Birla, Elena-Roxana Catanescu, Andrei Caragui, Silviu Constantinoiu
Carcinosarcoma is a rare form of ovarian cancer with mixed origin, and its association with mature teratoma is extremely rare. We present the case of patient T. M. aged 67, admitted into our clinic on the 15/05/2016, F.O. 4877 for the increase of the abdominal volume. On admission, the patient was afebrile, conscious, cooperative, cardio-respiratory balanced, having the abdomen distended in volume, sharp dullness in the flanks, positive wave sign bioumoral within normal limits except: uric acid = 6.64 mg / dL, serum glucose = 113...
2016: Chirurgia
https://www.readbyqxmd.com/read/27807064/mechanisms-and-targets-involved-in-dissemination-of-ovarian-cancer
#3
REVIEW
Ulrich H Weidle, Fabian Birzele, Gwendlyn Kollmorgen, Rüdiger Rueger
Ovarian carcinoma is associated with the highest death rate of all gynecological tumors. On one hand, its aggressiveness is based on the rapid dissemination of ovarian cancer cells to the peritoneum, the omentum, and organs located in the peritoneal cavity, and on the other hand, on the rapid development of resistance to chemotherapeutic agents. In this review, we focus on the metastatic process of ovarian cancer, which involves dissemination of, homing to and growth of tumor cells in distant organs, and describe promising molecular targets for possible therapeutic intervention...
November 2016: Cancer Genomics & Proteomics
https://www.readbyqxmd.com/read/27784340/il-12-expressing-oncolytic-herpes-simplex-virus-promotes-anti-tumor-activity-and-immunologic-control-of-metastatic-ovarian-cancer-in-mice
#4
Eric D Thomas, Selene Meza-Perez, Kerri S Bevis, Troy D Randall, G Yancey Gillespie, Catherine Langford, Ronald D Alvarez
BACKGROUND: Despite advances in surgical aggressiveness and conventional chemotherapy, ovarian cancer remains the most lethal cause of gynecologic cancer mortality; consequently there is a need for new therapeutic agents and innovative treatment paradigms for the treatment of ovarian cancer. Several studies have demonstrated that ovarian cancer is an immunogenic disease and immunotherapy represents a promising and novel approach that has not been completely evaluated in ovarian cancer...
October 27, 2016: Journal of Ovarian Research
https://www.readbyqxmd.com/read/27741368/intra-individual-genomic-heterogeneity-of-high-grade-serous-carcinoma-of-ovary-and-clinical-utility-of-ascitic-cancer-cells-for-mutation-profiling
#5
Youn Jin Choi, Je-Keun Rhee, Soo Young Hur, Min Sung Kim, Sung Hak Lee, Yeun-Jun Chung, Tae-Min Kim, Sug Hyung Lee
Intra-individual tumoural heterogeneity (ITH) is a hallmark of solid tumours and impedes accurate genomic diagnosis and selection of proper therapy. The purpose of this study was to identify ITH of ovarian high-grade serous carcinomas (OSCs) and to determine the utility of ascitic cancer cells as a resource for mutation profiling in spite of ITH. We performed whole-exome sequencing, copy number profiling, and DNA methylation profiling of four OSC genomes using multiregional biopsy from 13 intra-ovarian lesions, 12 extra-ovarian tumour lesions (omentum/peritoneum), and ascitic cells...
October 14, 2016: Journal of Pathology
https://www.readbyqxmd.com/read/27723802/nf-%C3%AE%C2%BAb-mediated-ccl20-reigns-dominantly-in-cxcr2-driven-ovarian-cancer-progression
#6
Rosa Mistica C Ignacio, Syeda M Kabir, Eun-Sook Lee, Samuel E Adunyah, Deok-Soo Son
Ovarian cancer is an inflammation-associated malignancy with a high mortality rate. CXCR2 expressing ovarian cancers are aggressive with poorer outcomes. We previously demonstrated that CXCR2-driven ovarian cancer progression potentiated NF-κB activation through EGFR-transactivated Akt. Here, we identified the chemokine signature involved in CXCR2-driven ovarian cancer progression using a mouse peritoneal xenograft model for ovarian cancer spreading with CXCR2-negative (SKA) and positive (SKCXCR2) cells generated previously from parental SKOV-3 cells...
2016: PloS One
https://www.readbyqxmd.com/read/27668427/characterization-of-the-expression-of-the-rna-binding-protein-eif4g1-and-its-clinicopathological-correlation-with-serous-ovarian-cancer
#7
Lanfang Li, Qingya Luo, Zhe Xie, Guiqin Li, Chengyi Mao, Yi Liu, Xin Wen, Na Yin, Jianzhong Cao, Jing Wang, Li Li, Jianhua Yu, Fang Wang, Ping Yi
BACKGROUND: Ovarian cancer is the most lethal type of malignant tumor in gynecological cancers and is associated with a high percentage of late diagnosis and chemotherapy resistance. Thus, it is urgent to identify a tumor marker or a molecular target that allows early detection and effective treatment. RNA-binding proteins (RBPs) are crucial in various cellular processes at the post-transcriptional level. The eukaryotic translation initiation factor 4 gamma, 1(eIF4G1), an RNA-binding protein, facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis...
2016: PloS One
https://www.readbyqxmd.com/read/27635270/sister-mary-joseph-nodule-as-a-first-manifestation-of-a-metastatic-ovarian-cancer
#8
Giannina Calongos, Mai Ogino, Takatoshi Kinuta, Masateru Hori, Tatsuo Mori
A 76-year-old female presented to our hospital with a 2 cm firm, nontender, protuberant umbilical nodule. She received treatment with antibiotics for suspected granuloma, with no improvement after two months. High levels of CA125 as well as an ovarian cyst and intrathoracic and intra-abdominal lesions on imaging studies made us suspect an ovarian cancer with a Sister Mary Joseph nodule (SMJN) and other metastases. A bilateral salpingo-oophorectomy and umbilical and omentum tumor resections were performed and a metastatic ovarian serous adenocarcinoma was diagnosed by histopathology...
2016: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27563880/guidance-of-signaling-activations-by-cadherins-and-integrins-in-epithelial-ovarian-cancer-cells
#9
REVIEW
Francesca Roggiani, Delia Mezzanzanica, Katia Rea, Antonella Tomassetti
Epithelial ovarian cancer (EOC) is the deadliest tumor among gynecological cancer in the industrialized countries. The EOC incidence and mortality have remained unchanged over the last 30 years, despite the progress in diagnosis and treatment. In order to develop novel and more effective therapeutic approaches, the molecular mechanisms involved in EOC progression have been thoroughly investigated in the last few decades. At the late stage, peritoneal metastases originate from the attachment of small clusters of cancer cells that shed from the primary site and carried by the ascites adhere to the abdominal peritoneum or omentum...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27500635/quantitation-of-intra-peritoneal-ovarian-cancer-metastasis
#10
Kyle A Lewellen, Matthew N Metzinger, Yueying Liu, M Sharon Stack
Epithelial ovarian cancer (EOC) is the leading cause of death from gynecologic malignancy in the United States. Mortality is due to diagnosis of 75% of women with late stage disease, when metastasis is already present. EOC is characterized by diffuse and widely disseminated intra-peritoneal metastasis. Cells shed from the primary tumor anchor in the mesothelium that lines the peritoneal cavity as well as in the omentum, resulting in multi-focal metastasis, often in the presence of peritoneal ascites. Efforts in our laboratory are directed at a more detailed understanding of factors that regulate EOC metastatic success...
2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27444787/ovarian-cancer-derived-ascitic-fluids-induce-a-senescence-dependent-pro-cancerogenic-phenotype-in-normal-peritoneal-mesothelial-cells
#11
Justyna Mikuła-Pietrasik, Paweł Uruski, Kinga Matuszkiewicz, Sebastian Szubert, Rafał Moszyński, Dariusz Szpurek, Stefan Sajdak, Andrzej Tykarski, Krzysztof Książek
PURPOSE: After the seeding ovarian cancer cells into the peritoneal cavity, ascitic fluid creates a microenvironment in which these cells can survive and disseminate. The exact nature of the interactions between malignant ascitic fluids and peritoneal mesothelial cells (HPMCs) in ovarian cancer progression has so far remained elusive. Here we assessed whether malignant ascitic fluids may promote the senescence of HPMCs and, by doing so, enhance the acquisition of their pro-cancerogenic phenotype...
October 2016: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/27313741/primary-peritoneal-serous-carcinoma-an-extremely-rare-malignancy-a-case-report-and-review-of-the-literature
#12
Woo-Sung Yun, Jung-Min Bae
Primary peritoneal serous carcinoma (PPSC) is an extremely rare malignancy that was first described in 1959. This type of cancer arises from the peritoneal epithelium and is similar to serous ovarian carcinoma. A diagnosis of PPSC is typically made based on the Gynecology Oncology Group criteria; however, a correct differential diagnosis of PPSC is difficult preoperatively. The current study describes the case of a 66 year-old female patient presenting with abdomen distension. A computed tomography (CT) scan revealed abundant ascites in the abdominal cavity and omental infiltration...
June 2016: Oncology Letters
https://www.readbyqxmd.com/read/27168004/diaphragmatic-resection-preserving-and-repairing-pericardium-splenectomy-and-distal-pancreatectomy-for-%C3%A4-nterval-debulk%C3%A4-ng-surgery-of-ovar%C3%A4-an-cancer
#13
Dogan Vatansever, Ali Emre Atici, Hamdullah Sozen, Onder Sakin
OBJECTIVE: The majority of ovarian cancer patients are initially diagnosed at an advanced-stage [1]. Upper abdominal bulky metastasis cephalad to the greater omentum reported to be present in 42% of patients [2]. Many complex surgical procedures such as splenectomy, pancreatectomy, mobilization and partial resection of liver, porta hepatis dissection, diaphragmatic peritonectomy and resection are frequently performed to achieve complete resection of metastatic disease [3]. Our aim in this surgical film is to show the resection of a left sided diaphragmatic implant located beneath the heart, with dissection from the pericardium after entrance to the pericardial cavity...
July 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27134480/bilateral-primary-fallopian-tube-papillary-serous-carcinoma-in-postmenopausal-woman-report-of-two-cases
#14
Dipanwita Nag, Parna Bhaumik, Ayandip Nandi, Aparajita Samaddar
Primary carcinoma of the fallopian tube is rare and accounts for about 0.14-1.8% of all gynecological malignancies. Correct diagnosis is rarely made preoperatively as clinically tubal carcinoma closely resembles ovarian carcinoma. Here, we report two cases of bilateral primary fallopian tube carcinomas. Case 1: A 54-year-old female presented with postmenopausal bleeding, abdominal pain, and pervaginal watery discharge for 10 days. Ultrasonography (USG) of pelvis showed endometrial thickening and multiple tiny echogenic foci in omentum suggestive of omental cake...
January 2016: Journal of Mid-life Health
https://www.readbyqxmd.com/read/27104939/ovarian-yolk-sac-tumor-the-experience-of-a-regional-cancer-center
#15
Xiaojing Wang, Zebiao Ma, Yanfang Li
OBJECTIVE: The aim of this study was to evaluate the clinicopathologic characteristics of patients with ovarian yolk sac tumor and the benefit of omentectomy in patients with clinical early-stage disease. METHODS: The medical records of 66 patients with ovarian yolk sac tumor were reviewed retrospectively. RESULTS: There were 37, 8, 14, and 7 patients with stages I, II, III, and IV disease, respectively. Sixty-five patients received surgery and adjuvant chemotherapy, and 1 had chemotherapy only...
June 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27091633/ultrasound-in-preoperative-assessment-of-pelvis-and-abdominal-spread-in-patients-with-ovarian-cancer-a-prospective-study
#16
D Fischerova, M Zikan, I Semeradova, J Slama, R Kocian, P Dundr, K Nemejcova, A Burgetova, L Dusek, D Cibula
OBJECTIVE: To analyze the accuracy of ultrasound in assessing pelvic and intra-abdominal disease in patients with ovarian cancer. METHODS: This prospective study enrolled all consecutive patients referred to a single gynecologic oncology center for suspected ovarian cancer. Only data with histologically confirmed primary ovarian cancer in patients who were evaluated under predefined preoperative ultrasound, intraoperative and pathologic protocols were analyzed. The rectosigmoid wall infiltration depth, peritoneal involvement in different compartments and metastatic lymph node presence were correlated with histopathology...
April 19, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27021436/exosomal-transfer-of-stroma-derived-mir21-confers-paclitaxel-resistance-in-ovarian-cancer-cells-through-targeting-apaf1
#17
Chi Lam Au Yeung, Ngai-Na Co, Tetsushi Tsuruga, Tsz-Lun Yeung, Suet-Ying Kwan, Cecilia S Leung, Yong Li, Edward S Lu, Kenny Kwan, Kwong-Kwok Wong, Rosemarie Schmandt, Karen H Lu, Samuel C Mok
Advanced ovarian cancer usually spreads to the visceral adipose tissue of the omentum. However, the omental stromal cell-derived molecular determinants that modulate ovarian cancer growth have not been characterized. Here, using next-generation sequencing technology, we identify significantly higher levels of microRNA-21 (miR21) isomiRNAs in exosomes and tissue lysates isolated from cancer-associated adipocytes (CAAs) and fibroblasts (CAFs) than in those from ovarian cancer cells. Functional studies reveal that miR21 is transferred from CAAs or CAFs to the cancer cells, where it suppresses ovarian cancer apoptosis and confers chemoresistance by binding to its direct novel target, APAF1...
March 29, 2016: Nature Communications
https://www.readbyqxmd.com/read/26958336/a-case-report-of-peritoneal-tuberculosis-with-multiple-miliary-peritoneal-deposits-mimicking-advanced-ovarian-carcinoma
#18
Shahla Yazdani, Mahmod Sadeghi, Abolhasan Alijanpour, Mojgan Naeimi-Rad
BACKGROUND: Peritoneal tuberculosis accounts 1-2% of all forms of tuberculosis. Peritoneal tuberculosis is an important differential diagnosis for ovarian cancer in women with ascites, adnexal mass and elevated cancer antigen 125 (CA125) levels. We report a case of a 32- year -old woman with multiple miliary peritoneal deposits mimicking advanced ovarian carcinoma. CASE PRESENTATION: A 32-year-old drug addicted woman presented with menometrorrhagia, fever and shivering, ascites and pelvis mass...
2016: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/26898799/smifh2-mediated-mdia-formin-functional-inhibition-potentiates-chemotherapeutic-targeting-of-human-ovarian-cancer-spheroids
#19
Megan A Ziske, Krista M Pettee, MaNada Khaing, Kaitlin Rubinic, Kathryn M Eisenmann
Due to a lack of effective screening or prevention protocol for epithelial ovarian cancer (EOC), there is a critical unmet need to develop therapeutic interventions for EOC treatment. EOC metastasis is unique. Initial dissemination is not primarily hematogenous, yet is facilitated through shedding of primary tumor cells into the peritoneal fluid and accumulating ascites. Increasingly, isolated patient spheroids point to a clinical role for spheroids in EOC metastasis. EOC spheroids are highly invasive structures that disseminate upon peritoneal mesothelium, and visceral tissues including liver and omentum...
March 25, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/26738030/a-method-for-voltage-measurements-of-cancerous-vs-non-cancerous-omentum
#20
W Wu, K Vitharana, T Gorgy, A Paterson, P Cunnea, H Gabra, C Fotopoulou, M G Boutelle, E M Drakakis
This paper presents and elaborates upon the practicalities of a method which enables the recording of voltage measurements from omental tissue in patients with advanced ovarian cancer. The key components of the proposed low-cost experimental setup are a tungsten electrode, a Ag/AgCl reference electrode and an instrumentation amplifier. Intriguingly, potential difference recordings between cancerous omentum and tissue culture media and between non-cancerous omentum and media, differ for tissue samples coming from the same patient...
2015: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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