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Omentum, ovarian cancer

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https://www.readbyqxmd.com/read/28520571/is-omentectomy-mandatory-among-early-stage-i-ii-malignant-ovarian-germ-cell-tumor-patients-a-retrospective-study-of-223-cases
#1
Wenyan Xu, Yanfang Li
OBJECTIVE: The aim of the study was to investigate whether omentectomy (OMT) is necessary in the operation for apparently early stage malignant ovarian germ cell tumors (MOGCTs). METHODS AND MATERIALS: Searching medical records database of Sun Yat-sen University Cancer Center from January 1, 1966, to November 30, 2015, patients with MOGCTs were identified and their age, year of diagnosis, tumor grade, histologic subtype, International Federation of Gynecology and Obstetrics stage, nodal findings, gross observation of omentum, and performance of OMT were assessed...
May 18, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28495239/prognostic-value-of-miliary-versus-non-miliary-sub-staging-in-advanced-ovarian-cancer
#2
Kevin H Eng, Kayla Morrell, Kristen Starbuck, Chandra Spring-Robinson, Aalia Khan, Dana Cleason, Levent Akman, Emese Zsiros, Kunle Odunsi, J Brian Szender
OBJECTIVE: The presence of miliary disease during initial ovarian cancer debulking may reflect a distinct mode of peritoneal spread independent from size-based tumor staging and may explain variation in response to treatment and survival outcomes. To infer the prevalence, presentation and clinical implications of miliary disease we reviewed existing surgical records. METHODS: Reports were available for 1008 primary debulking surgeries for ovarian, primary peritoneal or fallopian tube cancer between 2001 and 2015 (685 reports from 2005 to 2015)...
May 8, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28490413/risk-factors-for-appendiceal-involvement-in-women-with-epithelial-ovarian-cancer
#3
Mustafa Erkan Sarı, Elmas Korkmaz, Murat Öz, Tayfun Güngör, Mehmet Mutlu Meydanlı
OBJECTIVE: In this study we aimed to evaluate the risk factors for appendiceal involvement in women with epithelial ovarian cancer (EOC) who underwent appendectomy at the time of initial surgery. MATERIAL AND METHODS: Patients with a final diagnosis of EOC who underwent appendectomy at the time of initial surgery were evaluated retrospectively. Risk factors related to the presence of appendiceal involvement were analyzed. RESULTS: A total of 210 patients underwent appendectomy during staging surgery...
May 11, 2017: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/28456593/the-role-of-mir-372-in-ovarian-carcinoma-cell-proliferation
#4
Xue Guan, Zhi-Hong Zong, Shuo Chen, Xiu-Bo Sang, Dan-Dan Wu, Li-Li Wang, Yao Liu, Yang Zhao
OBJECTIVES: MicroRNA-372 has been shown to be associated with multiple tumors' development and progression, by regulating the expression of proteins involved in cell cycle and apoptosis. However, the specific mechanism and function of miR-372 in ovarian carcinoma are not clear. Our study explored the role of miR-372 in ovarian carcinoma cell cycle and proliferation. MATERIALS AND METHODS: MiR-372 expression was quantified in normal ovarian tissue, benign tumors, primary ovarian carcinomas and metastatic omentum by qRT-PCR...
April 26, 2017: Gene
https://www.readbyqxmd.com/read/28346091/a-high-throughput-screening-model-of-the-tumor-microenvironment-for-ovarian-cancer-cell-growth
#5
Madhu Lal-Nag, Lauren McGee, Rajarshi Guha, Ernst Lengyel, Hilary A Kenny, Marc Ferrer
The tumor microenvironment plays an important role in the processes of tumor growth, metastasis, and drug resistance. We have used a multilayered 3D primary cell culture model that reproduces the human ovarian cancer metastatic microenvironment to study the effect of the microenvironment on the pharmacological responses of different classes of drugs on cancer cell proliferation. A collection of oncology drugs was screened to identify compounds that inhibited the proliferation of ovarian cancer cells growing as monolayers or forming spheroids, on plastic and on a 3D microenvironment culture model of the omentum metastatic site, and also cells already in preformed spheroids...
June 2017: SLAS Discovery
https://www.readbyqxmd.com/read/28275576/the-unique-molecular-and-cellular-microenvironment-of-ovarian-cancer
#6
REVIEW
Thomas Worzfeld, Elke Pogge von Strandmann, Magdalena Huber, Till Adhikary, Uwe Wagner, Silke Reinartz, Rolf Müller
The reciprocal interplay of cancer cells and host cells is an indispensable prerequisite for tumor growth and progression. Cells of both the innate and adaptive immune system, in particular tumor-associated macrophages (TAMs) and T cells, as well as cancer-associated fibroblasts enter into a malicious liaison with tumor cells to create a tumor-promoting and immunosuppressive tumor microenvironment (TME). Ovarian cancer, the most lethal of all gynecological malignancies, is characterized by a unique TME that enables specific and efficient metastatic routes, impairs immune surveillance, and mediates therapy resistance...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28263384/mesothelium-expression-of-vascular-cell-adhesion-molecule-1-vcam-1-is-associated-with-an-unfavorable-prognosis-in-epithelial-ovarian-cancer-eoc
#7
Jennifer M Scalici, Sanja Arapovic, Erin J Saks, Kristen A Atkins, Gina Petroni, Linda R Duska, Jill K Slack-Davis
BACKGROUND: Mesothelium vascular cell adhesion molecule-1 (VCAM-1) expression in the metastatic epithelial ovarian cancer (EOC) microenvironment is induced by tumor and mediates tumor cell invasion. VCAM-1 imaging suggests expression during treatment is an indicator of platinum resistance. Here, we assess the potential prognostic significance of mesothelium VCAM-1 expression and prospectively evaluate whether soluble VCAM-1 (sVCAM-1) is a surrogate for mesothelium expression. METHODS: A retrospective review of EOC patients was performed to evaluate outcomes with mesothelium VCAM-1 expression determined by immunohistochemistry of peritoneum or omentum specimens...
May 15, 2017: Cancer
https://www.readbyqxmd.com/read/28114233/total-infragastric-omentectomy-including-the-vascular-perigastric-arcade-in-patients-with-advanced-serous-ovarian-tumors
#8
Gloria Cordeiro Vidal, Sabrina Croce, Frédéric Guyon, Guillaume Babin, Denis Querleu
OBJECTIVE: The aim of this study was to document the need of including the perigastric area when performing omentectomy in patients with stage III to IV serous epithelial ovarian tumors. PATIENTS AND METHODS: Patients undergoing omentectomy in the setting of surgery for advanced epithelial serous ovarian cancer between February and September 2015 were included. Patients with macroscopic involvement of the perigastric area, nonepithelial serous tumors, and recurrences of ovarian cancer were excluded...
February 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27857266/my-personal-journey-with-ovarian-cancer-treatment-caring-and-chemotherapy-tips
#9
Kim A Decker
Six years ago, I was diagnosed with stage IIIA ovarian low malignant cell potential cancer. It was the most shocking situation I have ever experienced. I didn't realize I had any symptoms, except occasional back pain, which I attributed to starting a new workout program. I had scheduled an abdominal computerized tomography (CT) scan for recurrent microscopic hematuria, which my internist wanted to check. I was told I would hear the results in two days. Two hours after my CT scan, while I was eating ice cream and watching television, an on-call genitourinary doctor (who I did not personally know) called to tell me the good news-that I had kidney stones, thus the microscopic hematuria...
December 1, 2016: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/27819640/mature-teratoma-associated-with-bilateral-ovarian-carcinosarcoma-accidental-association-or-etiopathogenetic-determinism-case-report
#10
Rodica Birla, Elena-Roxana Catanescu, Andrei Caragui, Silviu Constantinoiu
Carcinosarcoma is a rare form of ovarian cancer with mixed origin, and its association with mature teratoma is extremely rare. We present the case of patient T. M. aged 67, admitted into our clinic on the 15/05/2016, F.O. 4877 for the increase of the abdominal volume. On admission, the patient was afebrile, conscious, cooperative, cardio-respiratory balanced, having the abdomen distended in volume, sharp dullness in the flanks, positive wave sign bioumoral within normal limits except: uric acid = 6.64 mg / dL, serum glucose = 113...
2016: Chirurgia
https://www.readbyqxmd.com/read/27807064/mechanisms-and-targets-involved-in-dissemination-of-ovarian-cancer
#11
REVIEW
Ulrich H Weidle, Fabian Birzele, Gwendlyn Kollmorgen, Rüdiger Rueger
Ovarian carcinoma is associated with the highest death rate of all gynecological tumors. On one hand, its aggressiveness is based on the rapid dissemination of ovarian cancer cells to the peritoneum, the omentum, and organs located in the peritoneal cavity, and on the other hand, on the rapid development of resistance to chemotherapeutic agents. In this review, we focus on the metastatic process of ovarian cancer, which involves dissemination of, homing to and growth of tumor cells in distant organs, and describe promising molecular targets for possible therapeutic intervention...
November 2016: Cancer Genomics & Proteomics
https://www.readbyqxmd.com/read/27784340/il-12-expressing-oncolytic-herpes-simplex-virus-promotes-anti-tumor-activity-and-immunologic-control-of-metastatic-ovarian-cancer-in-mice
#12
Eric D Thomas, Selene Meza-Perez, Kerri S Bevis, Troy D Randall, G Yancey Gillespie, Catherine Langford, Ronald D Alvarez
BACKGROUND: Despite advances in surgical aggressiveness and conventional chemotherapy, ovarian cancer remains the most lethal cause of gynecologic cancer mortality; consequently there is a need for new therapeutic agents and innovative treatment paradigms for the treatment of ovarian cancer. Several studies have demonstrated that ovarian cancer is an immunogenic disease and immunotherapy represents a promising and novel approach that has not been completely evaluated in ovarian cancer...
October 27, 2016: Journal of Ovarian Research
https://www.readbyqxmd.com/read/27741368/intraindividual-genomic-heterogeneity-of-high-grade-serous-carcinoma-of-the-ovary-and-clinical-utility-of-ascitic-cancer-cells-for-mutation-profiling
#13
Youn Jin Choi, Je-Keun Rhee, Soo Young Hur, Min Sung Kim, Sung Hak Lee, Yeun-Jun Chung, Tae-Min Kim, Sug Hyung Lee
Intraindividual tumoural heterogeneity (ITH) is a hallmark of solid tumours and impedes accurate genomic diagnosis and selection of proper therapy. The aim of this study was to identify ITH of ovarian high-grade serous carcinomas (OSCs) and to determine the utility of ascitic cancer cells as a resource for mutation profiling in spite of ITH. We performed whole-exome sequencing, copy number profiling and DNA methylation profiling of four OSC genomes by using multiregional biopsies from 13 intraovarian lesions, 12 extraovarian tumour lesions (omentum/peritoneum), and ascitic cells...
January 2017: Journal of Pathology
https://www.readbyqxmd.com/read/27723802/nf-%C3%AE%C2%BAb-mediated-ccl20-reigns-dominantly-in-cxcr2-driven-ovarian-cancer-progression
#14
Rosa Mistica C Ignacio, Syeda M Kabir, Eun-Sook Lee, Samuel E Adunyah, Deok-Soo Son
Ovarian cancer is an inflammation-associated malignancy with a high mortality rate. CXCR2 expressing ovarian cancers are aggressive with poorer outcomes. We previously demonstrated that CXCR2-driven ovarian cancer progression potentiated NF-κB activation through EGFR-transactivated Akt. Here, we identified the chemokine signature involved in CXCR2-driven ovarian cancer progression using a mouse peritoneal xenograft model for ovarian cancer spreading with CXCR2-negative (SKA) and positive (SKCXCR2) cells generated previously from parental SKOV-3 cells...
2016: PloS One
https://www.readbyqxmd.com/read/27668427/characterization-of-the-expression-of-the-rna-binding-protein-eif4g1-and-its-clinicopathological-correlation-with-serous-ovarian-cancer
#15
Lanfang Li, Qingya Luo, Zhe Xie, Guiqin Li, Chengyi Mao, Yi Liu, Xin Wen, Na Yin, Jianzhong Cao, Jing Wang, Li Li, Jianhua Yu, Fang Wang, Ping Yi
BACKGROUND: Ovarian cancer is the most lethal type of malignant tumor in gynecological cancers and is associated with a high percentage of late diagnosis and chemotherapy resistance. Thus, it is urgent to identify a tumor marker or a molecular target that allows early detection and effective treatment. RNA-binding proteins (RBPs) are crucial in various cellular processes at the post-transcriptional level. The eukaryotic translation initiation factor 4 gamma, 1(eIF4G1), an RNA-binding protein, facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis...
2016: PloS One
https://www.readbyqxmd.com/read/27635270/sister-mary-joseph-nodule-as-a-first-manifestation-of-a-metastatic-ovarian-cancer
#16
Giannina Calongos, Mai Ogino, Takatoshi Kinuta, Masateru Hori, Tatsuo Mori
A 76-year-old female presented to our hospital with a 2 cm firm, nontender, protuberant umbilical nodule. She received treatment with antibiotics for suspected granuloma, with no improvement after two months. High levels of CA125 as well as an ovarian cyst and intrathoracic and intra-abdominal lesions on imaging studies made us suspect an ovarian cancer with a Sister Mary Joseph nodule (SMJN) and other metastases. A bilateral salpingo-oophorectomy and umbilical and omentum tumor resections were performed and a metastatic ovarian serous adenocarcinoma was diagnosed by histopathology...
2016: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27563880/guidance-of-signaling-activations-by-cadherins-and-integrins-in-epithelial-ovarian-cancer-cells
#17
REVIEW
Francesca Roggiani, Delia Mezzanzanica, Katia Rea, Antonella Tomassetti
Epithelial ovarian cancer (EOC) is the deadliest tumor among gynecological cancer in the industrialized countries. The EOC incidence and mortality have remained unchanged over the last 30 years, despite the progress in diagnosis and treatment. In order to develop novel and more effective therapeutic approaches, the molecular mechanisms involved in EOC progression have been thoroughly investigated in the last few decades. At the late stage, peritoneal metastases originate from the attachment of small clusters of cancer cells that shed from the primary site and carried by the ascites adhere to the abdominal peritoneum or omentum...
August 23, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27500635/quantitation-of-intra-peritoneal-ovarian-cancer-metastasis
#18
Kyle A Lewellen, Matthew N Metzinger, Yueying Liu, M Sharon Stack
Epithelial ovarian cancer (EOC) is the leading cause of death from gynecologic malignancy in the United States. Mortality is due to diagnosis of 75% of women with late stage disease, when metastasis is already present. EOC is characterized by diffuse and widely disseminated intra-peritoneal metastasis. Cells shed from the primary tumor anchor in the mesothelium that lines the peritoneal cavity as well as in the omentum, resulting in multi-focal metastasis, often in the presence of peritoneal ascites. Efforts in our laboratory are directed at a more detailed understanding of factors that regulate EOC metastatic success...
2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27444787/ovarian-cancer-derived-ascitic-fluids-induce-a-senescence-dependent-pro-cancerogenic-phenotype-in-normal-peritoneal-mesothelial-cells
#19
Justyna Mikuła-Pietrasik, Paweł Uruski, Kinga Matuszkiewicz, Sebastian Szubert, Rafał Moszyński, Dariusz Szpurek, Stefan Sajdak, Andrzej Tykarski, Krzysztof Książek
PURPOSE: After the seeding ovarian cancer cells into the peritoneal cavity, ascitic fluid creates a microenvironment in which these cells can survive and disseminate. The exact nature of the interactions between malignant ascitic fluids and peritoneal mesothelial cells (HPMCs) in ovarian cancer progression has so far remained elusive. Here we assessed whether malignant ascitic fluids may promote the senescence of HPMCs and, by doing so, enhance the acquisition of their pro-cancerogenic phenotype...
October 2016: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/27313741/primary-peritoneal-serous-carcinoma-an-extremely-rare-malignancy-a-case-report-and-review-of-the-literature
#20
Woo-Sung Yun, Jung-Min Bae
Primary peritoneal serous carcinoma (PPSC) is an extremely rare malignancy that was first described in 1959. This type of cancer arises from the peritoneal epithelium and is similar to serous ovarian carcinoma. A diagnosis of PPSC is typically made based on the Gynecology Oncology Group criteria; however, a correct differential diagnosis of PPSC is difficult preoperatively. The current study describes the case of a 66 year-old female patient presenting with abdomen distension. A computed tomography (CT) scan revealed abundant ascites in the abdominal cavity and omental infiltration...
June 2016: Oncology Letters
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