Masamichi Komatsu, Hiroshi Yamamoto, Takeshi Uehara, Yukihiro Kobayashi, Hironao Hozumi, Tomoyuki Fujisawa, Atsushi Miyamoto, Tomoo Kishaba, Fumihito Kunishima, Masaki Okamoto, Hideya Kitamura, Tae Iwasawa, Shoichiro Matsushita, Yasuhiro Terasaki, Shinobu Kunugi, Atsuhito Ushiki, Masanori Yasuo, Takafumi Suda, Masayuki Hanaoka
Immunoglobulin (Ig) G4-positive cells are rarely observed in the lungs of patients with idiopathic interstitial pneumonias (IIPs). IgG1 may be more pathogenic than IgG4, with IgG4 having both pathogenic and protective roles in IgG4-related disease (IgG4-RD). However, the role of both IgG1 and IgG4 in IIPs remains unclear. We hypothesized that patients with IgG4-positive interstitial pneumonia manifest different clinical characteristics than patients with IgG4-RD. Herein, we identified the correlation of the degree of infiltration of IgG1- and IgG4-positive cells with IIP prognosis, using a Japanese nationwide cloud-based database...
June 3, 2022: Scientific Reports