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https://www.readbyqxmd.com/read/28434376/pre-clinical-and-clinical-development-of-the-first-placental-malaria-vaccine
#1
Caroline Pehrson, Ali Salanti, Thor G Theander, Morten A Nielsen
Malaria during pregnancy is a massive health problem in endemic areas. Placental malaria infections caused by Plasmodium falciparum are responsible for up to one million babies being born with a low birth weight every year. Significant efforts have been invested into preventing the condition. Areas covered: Pub Med was searched using the broad terms "malaria parasite placenta" to identify studies of interactions between parasite and host, "prevention of placental malaria" to identify current strategies to prevent placental malaria, and "placental malaria vaccine" to identify pre-clinical vaccine development...
April 24, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28434201/how-much-alcohol-is-consumed-outside-of-the-lifetime-risk-guidelines-in-australia
#2
Sarah Callinan, Michael Livingston, Robin Room, Paul M Dietze
INTRODUCTION AND AIMS: This study aims to estimate the prevalence of long-term risky drinking within the Australian population and the proportion of standard drinks that is consumed outside of the long-term risk (LTR) guidelines of two Australian standard drinks (ASD) per day. DESIGN AND METHODS: Recruited by phone, 2020 Australian adults with an oversampling of risky drinkers were asked detailed questions about how much alcohol they consumed at a range of locations in 2013...
April 23, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/28411101/-surgical-management-of-primary-spindle-cell-sarcoma-of-prostate
#3
Keval N Patel, Rohit K Jha, Shashank J Pandya
Primary spindle cell sarcoma of prostate is an extremely rare malignancy and very few cases of it have been reported [1, 2]. We searched literature through Med-Line database using Pub-Med and Scopus for the articles published between January 1988 and September 2016. Our search was limited to the following keywords: "spindle cell sarcoma", "prostate" and "surgical management". Most of the papers focused on histopathology of the tumour; very few were found discussing the surgical management. We here present a case of localized primary spindle cell sarcoma of prostate operated at our institute with the difficulties we faced and their management...
April 11, 2017: Urology
https://www.readbyqxmd.com/read/28401948/development-and-validation-of-a-method-for-precise-dating-of-female-puberty-in-laboratory-rodents-the-puberty-ovarian-maturation-score-pub-score
#4
Francisco Gaytan, Concepción Morales, Silvia Leon, Violeta Heras, Alexia Barroso, Maria S Avendaño, Maria J Vazquez, Juan M Castellano, Juan Roa, Manuel Tena-Sempere
Puberty is a key developmental event whose primary regulatory mechanisms remain poorly understood. Precise dating of puberty is crucial for experimental (preclinical) studies on its complex neuroendocrine controlling networks. In female laboratory rodents, external signs of puberty, such as vaginal opening (VO) and epithelial cell cornification (i.e., first vaginal estrus, FE), are indirectly related to the maturational state of the ovary and first ovulation, which is the unequivocal marker of puberty. Whereas in rats, VO and FE are almost simultaneous with the first ovulation, these events are not so closely associated in mice...
April 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28392338/cannabis-exercise-performance-and-sport-a-systematic-review
#5
REVIEW
Michael C Kennedy
OBJECTIVES: To review the evidence relating to the effect of cannabis on exercise performance. DESIGN: A systematic review of published literature METHODS: Tetrahydrocannabinol (THC) is the principal psychoactive component of cannabis. A search was conducted using PUB med, Medline and Embase searching for cannabis, marijuana, cannabinoids and THC, in sport and exercise; the contents of sports medicine journals for the last 10 years; as well as cross references from journals and a personal collection of reprints...
March 21, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28386190/establishment-of-apoptotic-regulatory-network-for-genetic-markers-of-colorectal-cancer-and-optimal-selection-of-traditional-chinese-medicine-target
#6
Tongde Tian, Chuanliang Chen, Feng Yang, Jingwen Tang, Junwen Pei, Bian Shi, Ning Zhang, Jianhua Zhang
The paper aimed to screen out genetic markers applicable to early diagnosis for colorectal cancer and establish apoptotic regulatory network model for colorectal cancer, and to analyze the current situation of traditional Chinese medicine (TCM) target, thereby providing theoretical evidence for early diagnosis and targeted therapy of colorectal cancer. Taking databases including CNKI, VIP, Wanfang data, Pub Med, and MEDLINE as main sources of literature retrieval, literatures associated with genetic markers that are applied to early diagnosis of colorectal cancer were searched and performed comprehensive and quantitative analysis by Meta analysis, hence screening genetic markers used in early diagnosis of colorectal cancer...
March 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28386169/establishment-of-apoptotic-regulatory-network-for-genetic-markers-of-colorectal-cancer
#7
Yibin Hao, Guoyong Shan, Kejun Nan
Our purpose is to screen out genetic markers applicable to early diagnosis for colorectal cancer and to establish apoptotic regulatory network model for colorectal cancer, thereby providing theoretical evidence and targeted therapy for early diagnosis of colorectal cancer. Taking databases including CNKI, VIP, Wanfang data, Pub Med, and MEDLINE as main sources of literature retrieval, literatures associated with genetic markers applied to early diagnosis of colorectal cancer were searched to perform comprehensive and quantitative analysis by Meta analysis, hence screening genetic markers used in early diagnosis of colorectal cancer...
March 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28382413/neurodevelopmental-consequences-in-offspring-of-mothers-with-preeclampsia-during-pregnancy-underlying-biological-mechanism-via-imprinting-genes
#8
REVIEW
Yoko Nomura, Rosalind M John, Anna Bugge Janssen, Charles Davey, Jackie Finik, Jessica Buthmann, Vivette Glover, Luca Lambertini
PURPOSE: Preeclampsia is known to be a leading cause of mortality and morbidity among mothers and their infants. Approximately 3-8% of all pregnancies in the US are complicated by preeclampsia and another 5-7% by hypertensive symptoms. However, less is known about its long-term influence on infant neurobehavioral development. The current review attempts to demonstrate new evidence for imprinting gene dysregulation caused by hypertension, which may explain the link between maternal preeclampsia and neurocognitive dysregulation in offspring...
April 5, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28370857/gastrointestinal-toxicity-among-patients-taking-selective-cox-2-inhibitors-or-conventional-nsaids-alone-or-combined-with-proton-pump-inhibitors-a-case-control-study
#9
Mohammad Bakhriansyah, Patrick C Souverein, Anthonius de Boer, Olaf H Klungel
PURPOSE: To assess the risk of gastrointestinal perforation, ulcers, or bleeding (PUB) associated with the use of conventional nonsteroidal anti-inflammatory drugs (NSAIDs) with proton pump inhibitors (PPIs) and selective COX-2 inhibitors, with or without PPIs compared with conventional NSAIDs. METHODS: A case-control study was performed within conventional NSAIDs and/or selective COX-2 inhibitors users identified from the Dutch PHARMO Record Linkage System in the period 1998-2012...
March 31, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28361651/interrelationships-among-jumping-power-sprinting-power-and-pubertal-status-after-controlling-for-size-in-young-male-soccer-players
#10
Giovani S Cunha, Sean P Cumming, João Valente-Dos-Santos, João P Duarte, Gustavo Silva, Antonio C Dourado, Gabriela T Leites, Adroaldo C Gaya, Álvaro Reischak-Oliveira, Manuel Coelho-E-Silva
This study examined power output on jumping and sprinting tests in young soccer players of differing pubertal status, while controlling for body size with allometric scaling exponents. A total of 46 males aged 12-18 years (14.17 years) were divided into three groups: pre-pubescent ( n = 12), pubescent ( n = 22), and post-pubescent ( n = 12). Participants performed a series of tests, including the squat jump (SJ), countermovement jump (CMJ), and 10-meter and 30-meter sprint test protocols. The Post-PUB group was older ( F = 112...
April 2017: Perceptual and Motor Skills
https://www.readbyqxmd.com/read/28361258/effects-of-neonatal-excitotoxic-lesions-in-ventral-thalamus-on-social-interaction-in-the-rat
#11
Rainer Wolf, Henrik Dobrowolny, Sven Nullmeier, Bernhard Bogerts, Herbert Schwegler
The role of the thalamus in schizophrenia has increasingly been studied in recent years. Deficits in the ventral thalamus have been described in only few postmortem and neuroimaging studies. We utilised our previously introduced neurodevelopmental animal model, the neonatal excitotoxic lesion of the ventral thalamus of Sprague-Dawley rats (Wolf et al., Pharmacopsychiatry 43:99-109, 22). At postnatal day (PD7), male pubs received bilateral thalamic infusions with ibotenic acid (IBA) or artificial cerebrospinal fluid (control)...
March 30, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28338954/meta-analysis-of-cerebrospinal-fluid-cytokine-and-tryptophan-catabolite-alterations-in-psychiatric-patients-comparisons-between-schizophrenia-bipolar-disorder-and-depression
#12
Alexandre K Wang, Brian J Miller
INTRODUCTION: Schizophrenia, bipolar disorder, and major depressive disorder (MDD) have all been associated with immune system dysfunction, including aberrant cerebrospinal fluid (CSF) levels of cytokines and tryptophan catabolites; however, the pattern of alterations has not been compared across disorders. We performed a meta-analysis of CSF cytokine and tryptophan catabolites in patients with these major psychiatric disorders. METHODS: Articles were identified by searching Pub Med, PsycInfo, and Web of Science, and the reference lists of these studies...
March 17, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28334262/discriminating-the-reaction-types-of-plant-type-iii-polyketide-synthases
#13
Yugo Shimizu, Hiroyuki Ogata, Susumu Goto
Motivation: Functional prediction of paralogs is challenging in bioinformatics because of rapid functional diversification after gene duplication events combined with parallel acquisitions of similar functions by different paralogs. Plant type III polyketide synthases (PKSs), producing various secondary metabolites, represent a paralogous family that has undergone gene duplication and functional alteration. Currently, there is no computational method available for the functional prediction of type III PKSs...
March 6, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28333644/random-forest-classifier-for-zero-shot-learning-based-on-relative-attribute
#14
Yuhu Cheng, Xue Qiao, Xuesong Wang, Qiang Yu
For the zero-shot image classification with relative attributes (RAs), the traditional method requires that not only all seen and unseen images obey Gaussian distribution, but also the classifications on testing samples are made by maximum likelihood estimation. We therefore propose a novel zero-shot image classifier called random forest based on relative attribute. First, based on the ordered and unordered pairs of images from the seen classes, the idea of ranking support vector machine is used to learn ranking functions for attributes...
March 21, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28321939/examining-the-sociocultural-sensitivity-of-subjective-drunkenness-comparing-arab-and-jewish-israeli-pub-patrons
#15
Sharon R Sznitman, Shiran Bord, Wafa Elias, Anat Gesser-Edelsburg, Yoram Shiftan, Orna Baron-Epel
INTRODUCTION AND AIMS: Subjective drunkenness measures may be useful screening tools for alcohol-related problems. However, if self-reported drunkenness is influenced by social and cultural understandings, the measure may not predict drinking patterns equally across different sociocultural groups. The current study aims to determine whether the two main sociocultural groups in Israel (Arabs and Jews) are equally likely to report drunkenness at comparable levels of breath alcohol content (BrAC)...
March 20, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/28318669/-impact-of-onsite-or-dispatched-automated-external-defibrillator-use-on-early-survival-after-sudden-cardiac-arrest-occurring-in-international-airports
#16
Elena Linda Garcia, Sherry Caffrey-Villari, Diomeda Ramirez, Jean-Luc Caron, Patrice Mannhart, Paul-Georges Reuter, Frederic Lapostolle, Frederic Adnet
INTRODUCTION: Out-of-hospital cardiac arrest (OHCA) is a major public health challenge. Use of automated external defibrillators (AED) by laypersons improves survival of patient's victim of OHCA. The aim of our study was to compare onsite AED vs. dispatched AED management of cardiac arrest occurring in international airports. METHODS: We conducted a retrospective, observational, comparative, study on data collected from three international airports: Paris-Charles-de-Gaulle (CDG), Chicago and Madrid-Barajas...
March 15, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/28287981/perpas-topology-based-single-sample-pathway-analysis-method
#17
Chengyu Liu, Rainer Lehtonen, Sampsa Hautaniemi
Identification of intracellular pathways that play key roles in cancer progression and drug resistance is a prerequisite for developing targeted cancer treatments. The era of personalized medicine calls for computational methods that can function with one sample or very small set of samples. Developing such methods is challenging because standard statistical approaches pose several limiting assumptions, such as number of samples, that prevent their application when n approaches to one. We have developed a novel pathway analysis method called Per- PAS to estimate pathway activity at a single sample level by integrating pathway topology and transcriptomics data...
March 8, 2017: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/28276857/safety-considerations-of-anesthetic-drugs-in-children
#18
REVIEW
Raeford E Brown
Great strides have been made in the last twenty years in providing safe anesthesia care for infants and children. Despite a historical record of safety, recent findings have called to question the toxicities of many anesthetic agents. Observations concerning the inherent safety of these agents, their appropriate management in infants, and new findings which suggest overlooked toxicities will be discussed. Areas covered: A literature search using Pub Med identified journal articles relating to the safety of anesthetic agents in infants and children...
April 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28276439/structure-guided-mutagenesis-reveals-a-hierarchical-mechanism-of-parkin-activation
#19
Matthew Y Tang, Marta Vranas, Andrea I Krahn, Shayal Pundlik, Jean-François Trempe, Edward A Fon
Parkin and PINK1 function in a common pathway to clear damaged mitochondria. Parkin exists in an auto-inhibited conformation stabilized by multiple interdomain interactions. The binding of PINK1-generated phospho-ubiquitin and the phosphorylation of the ubiquitin-like (Ubl) domain of Parkin at Ser65 release its auto-inhibition, but how and when these events take place in cells remain to be defined. Here we show that mutations that we designed to activate Parkin by releasing the Repressor Element of Parkin (REP) domain, or by disrupting the interface between the RING0:RING2 domains, can completely rescue mutations in the Parkin Ubl that are defective in mitochondrial autophagy...
March 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/28270800/adaptation-to-blue-light-in-marine-synechococcus-requires-mpeu-an-enzyme-with-similarity-to-phycoerythrobilin-lyase-isomerases
#20
Rania M Mahmoud, Joseph E Sanfilippo, Adam A Nguyen, Johann A Strnat, Frédéric Partensky, Laurence Garczarek, Nabil Abo El Kassem, David M Kehoe, Wendy M Schluchter
Marine Synechococcus has successfully adapted to environments with different light colors, which likely contributes to this genus being the second most abundant group of microorganisms worldwide. Populations of Synechococcus that grow in deep, blue ocean waters contain large amounts of the blue-light absorbing chromophore phycourobilin (PUB) in their light harvesting complexes (phycobilisomes). Here, we show that all Synechococcus strains adapted to blue light possess a gene called mpeU. MpeU is structurally similar to phycobilin lyases, enzymes that ligate chromophores to phycobiliproteins...
2017: Frontiers in Microbiology
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