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https://www.readbyqxmd.com/read/28318669/-impact-of-onsite-or-dispatched-automated-external-defibrillator-use-on-early-survival-after-sudden-cardiac-arrest-occurring-in-international-airports
#1
Elena Linda Garcia, Sherry Caffrey-Villari, Diomeda Ramirez, Jean-Luc Caron, Patrice Mannhart, Paul-Georges Reuter, Frederic Lapostolle, Frederic Adnet
INTRODUCTION: Out-of-hospital cardiac arrest (OHCA) is a major public health challenge. Use of automated external defibrillators (AED) by laypersons improves survival of patient's victim of OHCA. The aim of our study was to compare onsite AED vs. dispatched AED management of cardiac arrest occurring in international airports. METHODS: We conducted a retrospective, observational, comparative, study on data collected from three international airports: Paris-Charles-de-Gaulle (CDG), Chicago and Madrid-Barajas...
March 15, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/28287981/perpas-topology-based-single-sample-pathway-analysis-method
#2
Chengyu Liu, Rainer Lehtonen, Sampsa Hautaniemi
Identification of intracellular pathways that play key roles in cancer progression and drug resistance is a prerequisite for developing targeted cancer treatments. The era of personalized medicine calls for computational methods that can function with one sample or very small set of samples. Developing such methods is challenging because standard statistical approaches pose several limiting assumptions, such as number of samples, that prevent their application when n approaches to one. We have developed a novel pathway analysis method called Per- PAS to estimate pathway activity at a single sample level by integrating pathway topology and transcriptomics data...
March 8, 2017: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/28276857/safety-considerations-of-anesthetic-drugs-in-children
#3
Raeford E Brown
Great strides have been made in the last twenty years in providing safe anesthesia care for infants and children. Despite a historical record of safety, recent findings have called to question the toxicities of many anesthetic agents. Observations concerning the inherent safety of these agents, their appropriate management in infants, and new findings which suggest overlooked toxicities will be discussed. Areas covered: A literature search using Pub Med identified journal articles relating to the safety of anesthetic agents in infants and children...
March 1, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28276439/structure-guided-mutagenesis-reveals-a-hierarchical-mechanism-of-parkin-activation
#4
Matthew Y Tang, Marta Vranas, Andrea I Krahn, Shayal Pundlik, Jean-François Trempe, Edward A Fon
Parkin and PINK1 function in a common pathway to clear damaged mitochondria. Parkin exists in an auto-inhibited conformation stabilized by multiple interdomain interactions. The binding of PINK1-generated phospho-ubiquitin and the phosphorylation of the ubiquitin-like (Ubl) domain of Parkin at Ser65 release its auto-inhibition, but how and when these events take place in cells remain to be defined. Here we show that mutations that we designed to activate Parkin by releasing the Repressor Element of Parkin (REP) domain, or by disrupting the interface between the RING0:RING2 domains, can completely rescue mutations in the Parkin Ubl that are defective in mitochondrial autophagy...
March 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/28270800/adaptation-to-blue-light-in-marine-synechococcus-requires-mpeu-an-enzyme-with-similarity-to-phycoerythrobilin-lyase-isomerases
#5
Rania M Mahmoud, Joseph E Sanfilippo, Adam A Nguyen, Johann A Strnat, Frédéric Partensky, Laurence Garczarek, Nabil Abo El Kassem, David M Kehoe, Wendy M Schluchter
Marine Synechococcus has successfully adapted to environments with different light colors, which likely contributes to this genus being the second most abundant group of microorganisms worldwide. Populations of Synechococcus that grow in deep, blue ocean waters contain large amounts of the blue-light absorbing chromophore phycourobilin (PUB) in their light harvesting complexes (phycobilisomes). Here, we show that all Synechococcus strains adapted to blue light possess a gene called mpeU. MpeU is structurally similar to phycobilin lyases, enzymes that ligate chromophores to phycobiliproteins...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28268221/cross-cultural-validity-in-self-reported-alcohol-use
#6
Sharon R Sznitman, Shiran Bord, Wafa Elias, Anat Gesser-Edelsburg, Yoram Shiftan, Orna Baron-Epel
BACKGROUND AND AIM: Little evidence is available on whether respondents from divergent sociocultural populations report alcohol consumption in systematically similar ways. Therefore, this study examined whether the validity of self-reported alcohol use differed between Arab and Jewish Israeli pub patrons. METHODS: The analytical sample consisted of 227 Arab and 900 Jewish Israeli pub patrons who were approached as they left pubs and asked to record their Breath Alcohol Content (BrAC) value and complete a questionnaire that probed into their alcohol use...
March 8, 2017: European Addiction Research
https://www.readbyqxmd.com/read/28263049/is-there-a-role-of-single-port-laparoscopy-in-the-treatment-of-endometriosis
#7
Angelos Daniilidis, Kimon Chatzistamatiou, Efstratios Assimakopoulos
BACKGROUND: Endometriosis is among the most common benign gynecological conditions, and it affects 6-15% of women of reproductive. During recent decades, minimally invasive surgical techniques, and especially laparoscopy, have gained significant ground concerning the treatment of gynecological disorders. To date, laparoscopy is considered the gold standard for the diagnosis and treatment of endometriosis. METHODS: Available papers in Pub Med and Scopus data base, written in English language have been used for the current narrative review...
March 6, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28255765/research-development-of-a-new-gnrh-antagonist-elagolix-for-the-treatment-of-endometriosis-a-review-of-the-literature
#8
REVIEW
Pontis Alessandro, Nappi Luigi, Sorrentino Felice, Paoletti Anna Maria, Melis Gian Benedetto, Angioni Stefano
PURPOSE: Limitated studies have reported the efficacy of GnRH antagonist on endometriosis symptoms. The aim of our study was to review all available trials to investigate the medical treatment of endometriosis with only GnRH antagonists, with special attention to pharmacodynamic activity, safety, and efficacy. METHODS: Pub Med and Sciencedirect database were searched using terms of "endometriosis treatment", "GnRH antagonist", and "Elagolix". The search was limited to clinical studies published in English...
April 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28239993/maternal-betaine-supplementation-in-rats-induces-intergenerational-changes-in-hepatic-igf-1-expression-and-dna-methylation
#9
Nannan Zhao, Shu Yang, Yun Hu, Haibo Dong, Ruqian Zhao
SCOPE: Betaine is widely used in animal nutrition to promote growth. Here we aimed to investigate whether maternal betaine supplementation during pregnancy can exert multigenerational effects on growth across two generations and the possible epigenetic modifications associated to such effects. METHODS AND RESULTS: In this study, 3-month-old female Sprague-Dawley rats were fed diet supplemented with 1% betaine throughout the pregnancy and lactation. Betaine-supplemented dams produced bigger litter but smaller F1 pups at birth and weaning...
February 26, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28184330/the-prevalence-of-migraine-in-iran-a-systematic-review-and-meta-analysis
#10
REVIEW
Zeynab Farhadi, Saeideh Alidoost, Meysam Behzadifar, Roghayeh Mohammadibakhsh, Najmeh Khodadadi, Razieh Sepehrian, Rahim Sohrabi, Masood Taheri Mirghaed, Morteza Salemi, Hamid Ravaghi, Masoud Behzadifar
CONTEXT: Migraine is a major dilemma and problem which affects public health and results to reduced quality of life. This study aimed to determine the prevalence of migraine in Iran. EVIDENCE ACQUISITION: A systematic search was conducted using Pub Med, Web of Science, Embase, Scopus, Ovid, Google Scholar, as well as Iranian databases including: MagIran, IranMedex and Scientific Information Databank, from 2000 to November, 2015. The Der-Simonian/Laird's random-effects model, with a 95% confidence interval was employed to estimate the overall pooled prevalence...
October 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/28177998/systematic-review-of-pelvic-exenteration-with-en-bloc-sacrectomy-for-recurrent-rectal-adenocarcinoma-r0-resection-predicts-disease-free-survival
#11
REVIEW
Amarasingam Sasikumar, Chetan Bhan, John T Jenkins, Anthony Antoniou, Jamie Murphy
BACKGROUND: The management of recurrent rectal cancer is challenging. At the present time, pelvic exenteration with en bloc sacrectomy offers the only hope of a lasting cure. OBJECTIVE: The purpose of this study was to evaluate clinical outcome measures and complication rates following sacrectomy for recurrent rectal cancer. DATA SOURCES: A search was conducted on Pub Med for English language articles relevant to sacrectomy for recurrent rectal cancer with no time limitations...
March 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28159951/the-accuracy-of-tactile-assessment-of-fever-in-children-by-caregivers-a-systematic-review-and-meta-analysis
#12
Yan-Wei Li, Le-Shan Zhou, Xing Li
CONTEXT: Fever is the most common complaint in the pediatric and emergency departments. Caregivers prefer to detect fever in their children by tactile assessment. OBJECTIVE: The purpose of this systematic review was to summarize the evidence on the accuracy of caregivers' tactile assessment for detecting fever in children. EVIDENCE-ACQUISITION: We performed a literature search of Cochrane Library, Pub Med, Web of Knowledge, EMBASE (ovid), EBSCO and Google Scholar, without restriction of publication date, to identify English articles assessing caregivers' ability of detecting fever in children by tactile assessment...
February 2, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28155227/a-new-cave-dwelling-loach-triplophysa-xichouensis-sp-nov-teleostei-nemacheilidae-from-yunnan-china
#13
S W Liu, X F Pan, J X Yang, X Y Chen
A new cave-dwelling loach of the genus Triplophysa, T. xichouensis, is described from an outlet of a subterranean river in Xisa Town, Xichou County, Yunnan Province, China. It can be distinguished from its congeners by the following characters: dorsal-fin rays iii, 8; anal-fin rays ii, 6; pectoral-fin rays i, 9 or 10; pelvic-fin rays i, 5 or 6; branched caudal-fin rays 16(8+8); eyes highly degenerated to a very tiny black dot; dorsal-fin origin closer to snout tip than to caudal-fin base and anterior to vertical line of pelvic-fin origin; pectoral fin length about two-thirds the distance between pectoral-fin origin to pelvic-fin origin; caudal peduncle slender, its length about three times its depth; caudal fin emarginate; body smooth and scaleless; lateral line complete and straight; anterior chamber of air bladder wrapped in dumbbell-shaped bony capsule and the posterior one well developed, long, oval; intestine short, bending in zigzag shape behind stomach...
February 2, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/28155051/a-review-on-animal-models-and-treatments-for-the-reconstruction-of-achilles-and-flexor-tendons
#14
Marta Bottagisio, Arianna B Lovati
Tendon is a connective tissue mainly composed of collagen fibers with peculiar mechanical properties essential to functional movements. The increasing incidence of tendon traumatic injuries and ruptures-associated or not with the loss of tissue-falls on the growing interest in the field of tissue engineering and regenerative medicine. The use of animal models is mandatory to deepen the knowledge of the tendon healing response to severe damages or acute transections. Thus, the selection of preclinical models is crucial to ensure a successful translation of effective and safe innovative treatments to the clinical practice...
March 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28133477/early-diagnosis-of-helicobacter-pylori-infection-in-vietnamese-patients-with-acute-peptic-ulcer-bleeding-a-prospective-study
#15
Duc Trong Quach, Mai Ngoc Luu, Toru Hiyama, Thuy-HuongThi To, Quy Nhuan Bui, Tuan Anh Tran, Binh Duy Tran, Minh-Cong Hong Vo, Shinji Tanaka, Naomi Uemura
Aims. To investigate H. pylori infection rate and evaluate a combined set of tests for H. pylori diagnosis in Vietnamese patients with acute peptic ulcer bleeding (PUD). Methods. Consecutive patients with acute PUB were enrolled prospectively. Rapid urease test (RUT) with 3 biopsies was carried out randomly. Patients without RUT or with negative RUT received urea breath test (UBT) and serological and urinary H. pylori antibody tests. H. pylori was considered positive if RUT or any noninvasive test was positive...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28127354/dna-amplification-techniques-for-the-detection-of-toxoplasma-gondii-tissue-cysts-in-meat-producing-animals-a-narrative-review-article
#16
REVIEW
Farooq Riaz, Imran Rashid, Haroon Akbar, Wasim Shehzad, Saher Islam, Amna Arshad Bajwa, Khalid Saeed, Kamran Ashraf
BACKGROUND: Toxoplasma gondii is an intracellular parasite, which infects one-third population of world. Humans and animals acquire infection by ingesting oocytes from feces of cats or by meat of other animals having cysts that may lead to congenital, ocular or cephalic toxoplasmosis. Either it is important to detect T. gondii from meat of food animals from retail shops or directly at slaughterhouses, which is meant for export. METHODS: The current research was done without time limitation using such terms as follows: "Toxoplasma gondii", "Meat", "Tissue cyst", "PCR", "LAMP", "Screening" and "Immunological assay" alone or in combination, in English language...
October 2016: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28126365/prenatal-acetaminophen-use%C3%A2-and-outcomes%C3%A2-in%C3%A2-children
#17
(no author information available yet)
No abstract text is available yet for this article.
March 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28126097/spaces-of-encounter-and-attitudes-towards-difference-a-comparative-study-of-two-european-cities
#18
Aneta Piekut, Gill Valentine
Scholars have been increasingly interested in how everyday interactions in various places with people from different ethnic/religious background impact inter-group relations. Drawing on representative surveys in Leeds and Warsaw (2012), we examine whether encounters with ethnic and religious minorities in different type of space are associated with more tolerance towards them. We find that in Leeds, more favourable affective attitudes are associated with contact in institutional spaces (workplace and study places) and socialisation spaces (social clubs, voluntary groups, religious meeting places); however, in case of behavioural intentions - operationalised as willingness to be friendly to minority neighbours - only encounters in socialisation spaces play a significant role in prejudice reduction...
February 2017: Social Science Research
https://www.readbyqxmd.com/read/28120652/drinking-at-local-pub-linked-to-improved-well-being
#19
(no author information available yet)
Moderate alcohol consumption with friends at a local pub could be linked to improved well-being, say researchers at the University of Oxford.
January 25, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28108156/the-role-of-ultrasound-in-women-who-undergo-cell-free-dna-screening
#20
Mary E Norton, Joseph R Biggio, Jeffrey A Kuller, Sean C Blackwell
The introduction of cell-free DNA screening for aneuploidy into obstetric practice in 2011 revolutionized the strategies utilized for prenatal testing. The purpose of this document is to review the current data on the role of ultrasound in women who have undergone or are considering cell-free DNA screening. The following are Society for Maternal-Fetal Medicine recommendations: (1) in women who have already received a negative cell-free DNA screening screen, ultrasound at 11-14 weeks of gestation solely for the purpose of nuchal translucency measurement (Current Procedural Terminology code 76813) is not recommended (grade 1B); (2) we recommend that diagnostic testing should not be recommended to patients solely for the indication of an isolated soft marker in the setting of a negative cell-free DNA screen (grade 2B); (3) in women with an isolated soft marker without other clinical implications (ie, choroid plexus cyst or echogenic intracardiac focus) and a negative cell-free DNA screen, we recommend describing the finding as not clinically significant or as a normal variant (grade 2B); (4) in women with an isolated soft marker that has no other clinical implication (ie, choroid plexus cyst or echogenic intracardiac focus) and a negative first- or second-trimester screening result, we recommend describing the finding as not clinically significant or as a normal variant (grade 2B); (5) we recommend that all women in whom a structural abnormality is identified by ultrasound should be offered diagnostic testing with chromosomal microarray (grade 1A); and (6) we recommend against routine screening for microdeletions with cell-free DNA screening (grade 1B)...
January 17, 2017: American Journal of Obstetrics and Gynecology
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