V André, D Longoni, S Bresolin, C Cappuzzello, E Dander, M Galbiati, C Bugarin, A Di Meglio, E Nicolis, E Maserati, M Serafini, A J Warren, G Te Kronnie, G Cazzaniga, L Sainati, M Cipolli, A Biondi, G D'Amico
Shwachman-Diamond syndrome (SDS) is a rare inherited disorder characterized by bone marrow (BM) dysfunction and exocrine pancreatic insufficiency. SDS patients have an increased risk for myelodisplastic syndrome and acute myeloid leukemia. Mesenchymal stem cells (MSCs) are the key component of the hematopoietic microenvironment and are relevant in inducing genetic mutations leading to leukemia. However, their role in SDS is still unexplored. We demonstrated that morphology, growth kinetics and expression of surface markers of MSCs from SDS patients (SDS-MSCs) were similar to normal MSCs...
October 12, 2012: Blood Cancer Journal