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https://www.readbyqxmd.com/read/28098958/perilesional-hyperintensity-on-t1-weighted-images-in-intra-axial-brain-masses-other-than-cavernous-malformations
#1
S Ali Nabavizadeh, Dasha Pechersky, J Eric Schmitt, MacLean Nasrallah, Ronald Wolf, Laurie Loevner, Alexander C Mamourian
BACKGROUND AND PURPOSE: Hyperintensity on T1-weighted imaging in perilesional vasogenic edema has been reported as a useful sign for differentiating cavernous malformation from other hemorrhagic intra-axial masses. In this study, we investigated the frequency of perilesional hyperintensity on T1-weighted imaging in patients with intra-axial hemorrhagic and nonhemorrhagic brain masses. METHODS: The study was performed with the approval of the institutional review board...
January 18, 2017: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/28058711/hyperglycemia-is-associated-with-poor-survival-in-primary-central-nervous-system-lymphoma-patients
#2
Ayumi Debata, Koichi Yoshida, Kenta Ujifuku, Haruna Yasui, Kensaku Kamada, Daisuke Niino, Takayuki Matsuo
PURPOSE: Primary central nervous system lymphoma (PCNSL) is a type of non-Hodgkin lymphoma (NHL), and it has been postulated that metabolic disorder may contribute to NHL etiology. We retrospectively investigated the prognostic significance of hyperglycemia in patients with PCNSL. We evaluated glucose transporter type 1 (GLUT1) expression by immunohistochemistry and analyzed its association with hyperglycemia and survival. METHODS: The medical and neuroradiologic records of 50 patients with PCNSL at our institution over the past 15 years were analyzed...
December 29, 2016: Tumori
https://www.readbyqxmd.com/read/28035316/primary-pediatric-mid-brain-lymphoma-report-of-a-rare-pediatric-tumor-in-a-rare-location
#3
Rony Benson, Supriya Mallick, Suvendu Purkait, Vaishali Suri, K P Haresh, Subhash Gupta, Dayanand Sharma, Pramod Kumar Julka, Goura Kishore Rath
Primary central nervous system lymphoma (PCNSL) is a rare disease in pediatric age group. A thirteen-year-old male child presented with complaints of headache for six months, vomiting and diplopia for three days. Magnetic resonance imaging of the brain showed a single lesion of 1.7 cm × 1.6 cm × 1.6 cm in the mid brain and tectum. He underwent a gross total resection of the tumor. The histopathological evaluation revealed B cell high grade non Hodgkin lymphoma. The patient was treated with High dose methotrexate and cranio spinal radiation...
December 16, 2016: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/28024493/-clinicopathological-features-of-primary-central-nervous-system-lymphoma-and-their-influence-on-prognosis-of-desease
#4
Chao-Yang DU, Ru-Yu Yang, Chao Li, Li-Juan Duan
OBJECTIVE: To study the clinical features of of patients with primary central nervous system lymphoma(PCNSL) and their influence on prognosis. METHODS: Forty-two cases of PCNSL hospitallized in our hospital from January 2012 to December 2015 were selected, and the laboratory analysis, imaging examination, bone marrow analysis and pathological examination all were performed, 26 cases were treated by lumbar puncture combined with intrathecal injection of drugs (Ara C, dexamethason and methotrexate), 8 cases were treated by methotrexate combined with rituximab, 8 cases voluntanly abandon treatment after being diagnosed as PCNSL...
December 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/28012348/utility-of-post-therapy-brain-surveillance-imaging-in-the-detection-of-primary-central-nervous-system-lymphoma-relapse
#5
Gaëlle Fossard, Céline Ferlay, Emmanuelle Nicolas-Virelizier, Philippe Rey, François Ducray, Emmanuel Jouanneau, Pierre Faurie, Amine Belhabri, Marie-Pierre Sunyack, Catherine Chassagne-Clément, Philippe Thiesse, Catherine Sebban, Pierre Biron, Jean-Yves Blay, Hervé Ghesquières
BACKGROUND: The optimal follow-up strategy for primary central nervous system lymphoma (PCNSL) patients after first-line therapy is unclear. The goal of this study is to determine the utility of planned brain surveillance imaging in the detection of relapse in a retrospective cohort of PCNSL patients. METHODS: Patients were consecutive PCNSL cases treated in Leon Berard Cancer Centre, Lyon, France, from 1985 to 2011. Histology was diffuse large B-cell lymphoma in 94%...
December 21, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/28002793/next-generation-sequencing-of-vitreoretinal-lymphomas-from-small-volume-intraocular-liquid-biopsies-new-routes-to-targeted-therapies
#6
Andi K Cani, Daniel H Hovelson, Hakan Demirci, Mark W Johnson, Scott A Tomlins, Rajesh C Rao
BACKGROUND: Vitreoretinal lymphoma (VRL), the most common lymphoma of the eye, is a rare form of primary CNS lymphoma (PCNSL). Most frequently a high-grade diffuse large B cell lymphoma, VRL can cause vision loss and its prognosis remains dismal: the overall survival time is 3 years after diagnosis. Radiotherapy and chemotherapy are used but remain frequently ineffective, and no standardized treatment regimen exists. Furthermore, no biologically targeted treatments, based on the genetic profile of the tumor, are available, as VRL has hitherto not comprehensively been profiled...
December 17, 2016: Oncotarget
https://www.readbyqxmd.com/read/27994065/patterns-of-response-and-relapse-in-primary-cns-lymphomas-after-first-line-chemotherapy-imaging-analysis-of-the-anocef-goelams-prospective-randomized-trial
#7
E Tabouret, C Houillier, N Martin-Duverneuil, M Blonski, C Soussain, H Ghesquières, R Houot, D Larrieu, P Soubeyran, R Gressin, E Gyan, O Chinot, L Taillandier, S Choquet, A Alentorn, D Leclercq, A Omuro, M L Tanguy, K Hoang-Xuan
BACKGROUND: Our aim was to review MRI characteristics of patients with primary CNS lymphoma (PCNSL) enrolled in a randomized phase II trial and to evaluate their potential prognostic value and patterns of relapse, including T2 fluid attenuated inversion recovery (FLAIR) MRI abnormalities. METHODS: Neuroimaging findings in 85 patients with PCNSL enrolled in a prospective trial were reviewed blinded to outcomes. MRI characteristics and responses according to International PCNSL Collaborative Group (IPCG) criteria were correlated with progression-free survival (PFS) and overall survival (OS)...
December 18, 2016: Neuro-oncology
https://www.readbyqxmd.com/read/27959415/promoter-methylation-attenuates-shp1-expression-and-function-in-patients-with-primary-central-nervous-system-lymphoma
#8
Jing Liu, Yaming Wang, Xuefei Sun, Nan Ji, Shengjun Sun, Yajie Wang, Fusheng Liu, Qu Cui, Chen Wang, Yuanbo Liu
The Src homology region 2 domain-containing phosphatase-1 (SHP1) is a critical negative regulator involved in the JAK/STAT signaling pathway. The SHP1 gene has been proposed as a candidate tumor suppressor in solid and hematological malignancies and promoter methylation is an important biological process in controlling tumorigenesis. However, the detailed roles of SHP1 promoter methylation in the pathogenesis of primary central nervous system lymphoma (PCNSL) is largely unknown. In the present study, we evaluated the correlation between SHP1 expression and promoter methylation in patients with PCNSL...
February 2017: Oncology Reports
https://www.readbyqxmd.com/read/27924864/cerebrospinal-fluid-il-10-and-il-10-il-6-as-accurate-diagnostic-biomarkers-for-primary-central-nervous-system-large-b-cell-lymphoma
#9
Yang Song, Wei Zhang, Li Zhang, Wei Wu, Yan Zhang, Xiao Han, Chen Yang, Lu Zhang, Daobin Zhou
Early diagnosis of primary central nervous system lymphoma (PCNSL) represents a challenge, and cerebrospinal fluid (CSF) cytokines may be diagnostic biomarkers for PCNSL. We used an electrochemiluminescence immunoassay to measure interleukin (IL)-10, IL-6, IL-8 and tumor necrosis factor α (TNF-α) in the CSF of 22 B cell PCNSL patients and 80 patients with other CNS diseases. CSF IL-10 was significantly higher in PCNSL patients than in the control group (median 74.7 pg/ml vs < 5.0 pg/ml, P < 0...
December 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27913504/primary-central-nervous-system-lymphoma
#10
Tracy T Batchelor
Primary central nervous system lymphoma (PCNSL) is an extranodal non-Hodgkin lymphoma (NHL) confined to the brain, leptomeninges, eyes, or spinal cord. The majority of PCNSL cases occur in the immunocompetent host, the focus of this review. The prognosis of PCNSL is inferior to that of other NHL subtypes including other organ-specific subtypes of extranodal NHL. The 5- and 10-year survival proportions for PCNSL are 29.3% and 21.6%, respectively. The diagnosis and management of PCNSL differs from that of other primary brain cancers and NHL in other parts of the body...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27894359/can-morphological-mri-differentiate-between-primary-central-nervous-system-lymphoma-and-glioblastoma
#11
H Malikova, E Koubska, J Weichet, J Klener, A Rulseh, R Liscak, Z Vojtech
BACKGROUND: Primary central nervous system lymphoma (PCNSL) is a rare, aggressive brain neoplasm that accounts for roughly 2-6% of primary brain tumors. In contrast, glioblastoma (GBM) is the most frequent and severe glioma subtype, accounting for approximately 50% of diffuse gliomas. The aim of the present study was to evaluate morphological MRI characteristics in histologically-proven PCNSL and GBM at the time of their initial presentation. METHODS: We retrospectively evaluated standard diagnostic MRI examinations in 54 immunocompetent patients (26 female, 28 male; age 62...
November 29, 2016: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/27884882/lymphomatosis-cerebri-diagnostic-challenges-and-review-of-the-literature
#12
Paul J Lee, Idanis Berrios, Carolina Ionete, Thomas Smith
Lymphomatosis cerebri (LC) is a rare variant of a primary central nervous system non-Hodgkin's lymphoma (PCNSL) characterised by diffuse infiltration of tumour cells throughout the brain parenchyma. We present a 68-year-old immunocompetent woman with headaches, dizziness, blurred vision, localised right leg weakness and rapidly progressive dementia. A brain MRI demonstrated diffuse T2 hyperintense white matter lesions that did not enhance with contrast. The clinical differential diagnosis of these lesions included metastatic disease, infectious or inflammatory process such as sarcoidosis, lymphoma, demyelinating disease and less likely vascular aetiology, such as vasculitis or ischaemic stroke...
November 24, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27867930/a-case-of-primary-central-nervous-system-lymphoma-located-at-brain-stem-in-a-child
#13
Jinho Kim, Young Zoon Kim
Primary central nervous system lymphoma (PCNSL) is an extranodal Non-Hodgkin's lymphoma that is confined to the brain, eyes, and/or leptomeninges without evidence of a systemic primary tumor. Although the tumor can affect all age groups, it is rare in childhood; thus, its incidence and prognosis in children have not been well defined and the best treatment strategy remains unclear. A nine-year old presented at our department with complaints of diplopia, dizziness, dysarthria, and right side hemiparesis. Magnetic resonance image suggested a diffuse brain stem glioma with infiltration into the right cerebellar peduncle...
October 2016: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/27857050/central-nervous-system-lymphoma-a-morphological-mri-study
#14
Eva Koubska, Jiri Weichet, Hana Malikova
OBJECTIVES: The aim of the present study was to evaluate morphological MRI findings in histologically-proven central nervous system lymphoma (CNSL) at time of their first appearance, and to describe dynamic changes on repeat MRI before the diagnosis was histologically proven. METHODS: We retrospectively evaluated the MRI examinations of 74 patients with histologically-proven CNSL (10 secondary CNSL, 64 primary PCNSL; 10 immunocompromised, 54 immunocompetent). In 43 patients, we evaluated the evolution of CNSL on MRI before the diagnosis was proven...
September 2016: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/27843136/high-dose-methotrexate-based-immuno-chemotherapy-for-elderly-primary-cns-lymphoma-patients-primain-study
#15
K Fritsch, B Kasenda, E Schorb, P Hau, J Bloehdorn, R Möhle, S Löw, M Binder, J Atta, U Keller, H-H Wolf, S W Krause, G Heß, R Naumann, S Sasse, C Hirt, M Lamprecht, U Martens, A Morgner, J Panse, N Frickhofen, A Röth, C Hader, M Deckert, H Fricker, G Ihorst, J Finke, G Illerhaus
To investigate immuno-chemotherapy for elderly immuno-competent patients (⩾65 years) with newly diagnosed primary central nervous system lymphoma, we conducted a multicentre single-arm trial. One cycle consisted of rituximab (375 mg/m(2), days 1, 15, 29), high-dose methotrexate (3 g/m(2) days 2, 16, 30), procarbazine (60 mg/m(2) days 2-11) and lomustine (110 mg/m(2), day 2)-R-MPL protocol. Owing to infectious complications, we omitted lomustine during the study and consecutive patients were treated with the R-MP protocol...
December 9, 2016: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/27784367/-manifestations-of-pet-ct-imaging-in-primary-central-nervous-system-lymphoma
#16
Liang Yin, Zhi-Chun Lin, Jian-Lan Yue, Shi-Ming Huang, Wei Chen
OBJECTIVE: To investigate the PET/CT features of primary central nervous system lymphoma(PCNSL). METHODS: A retrospective analysis of PET/CT imaging manifestations and clinical data was performed in 4 PCNSL cases which were confirmed by surgery or stereotactic pathologic biopsy. RESULTS: The pathologic biopsy in 4 patients all showed diffuse large B cell lymphoma with a total of 8 lesions. All cases were performed with (18)F-FDG PET/CT imaging except 1 patient simultaneously with (18)F-FLT PET/CT imaging in the brain...
October 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/27752883/promising-treatment-results-with-blood-brain-barrier-disruption-bbbd-based-immunochemotherapy-combined-with-autologous-stem-cell-transplantation-asct-in-patients-with-primary-central-nervous-system-lymphoma-pcnsl
#17
Hanne Kuitunen, Susanna Tokola, Topi Siniluoto, Matti Isokangas, Eila Sonkajärvi, Seppo Alahuhta, Taina Turpeenniemi-Hujanen, Esa Jantunen, Tapio Nousiainen, Kaija Vasala, Outi Kuittinen
Primary central nervous system lymphoma (PCNSL) is a rare brain tumour with a dismal prognosis. Several phase II studies with high-dose methotrexate-based regimens have shown promising early results, but in all hospital-based data published so far, the disease outcome has been poor. Patients with relapsed or refractory disease have a dismal prognosis. We performed retrospective analysis to evaluate results and tolerabilities of BBBD therapy in combination with high-dose therapy supported by autologous stem cell transplantation...
October 17, 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27713090/a-comprehensive-assessment-of-toxicities-in-patients-with-central-nervous-system-lymphoma-undergoing-autologous-stem-cell-transplantation-using-thiotepa-busulfan-and-cyclophosphamide-conditioning
#18
Michael Scordo, Valkal Bhatt, Meier Hsu, Antonio M Omuro, Matthew J Matasar, Lisa M DeAngelis, Parastoo B Dahi, Craig H Moskowitz, Sergio A Giralt, Craig S Sauter
High-dose therapy and autologous stem cell transplantation (ASCT) with thiotepa, busulfan, and cyclophosphamide (TBC) conditioning has emerged as an effective postinduction treatment strategy for patients with primary central nervous system lymphoma (PCNSL) or secondary central nervous system lymphoma (SCNSL), but it is associated with considerable toxicity and transplantation-related mortality (TRM) in the modern era. Forty-three adult patients with chemosensitive PCNSL or SCNSL underwent TBC-conditioned ASCT between 2006 and 2015...
January 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/27709813/expression-of-tim-1-in-primary-cns-lymphoma
#19
Wataru Kishimoto, Momoko Nishikori, Hiroshi Arima, Hiroaki Miyoshi, Yuya Sasaki, Toshio Kitawaki, Kotaro Shirakawa, Takeharu Kato, Yoshitaka Imaizumi, Takayuki Ishikawa, Hitoshi Ohno, Hironori Haga, Koichi Ohshima, Akifumi Takaori-Kondo
Primary central nervous system lymphoma (PCNSL) is a distinct subtype of extranodal lymphoma with aggressive clinical course and poor outcome. As increased IL-10/IL-6 ratio is recognized in the cerebrospinal fluid (CSF) of PCNSL patients, we hypothesized that PCNSL might originate from a population of B cells with high IL-10-producing capacity, an equivalent of "regulatory B cells" in mice. We intended in this study to clarify whether Tim-1, a molecule known as a marker for regulatory B cells in mice, is expressed in PCNSL...
November 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27703297/primary-central-nervous-system-anaplastic-large-t-cell-lymphoma
#20
Bruno Splavski, Dario Muzevic, Tatjana Ladenhauser-Palijan, Brano Splavski
INTRODUCTION: Primary central nervous system lymphoma (PCNSL) of T-cell origin is an exceptionally rare, highly malignant intracranial neoplasm. Although such a tumor typically presents with a focal mass lesion. CASE REPORT: Past medical history of a 26-year-old male patient with a PCNS lymphoma of T-cell origin was not suggestive of intracranial pathology or any disorder of other organs and organic systems. To achieve a gross total tumor resection, surgery was performed via osteoplastic craniotomy using the left frontal transcortical transventricular approach...
July 27, 2016: Medical Archives
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