keyword
MENU ▼
Read by QxMD icon Read
search

Primary central nervous system lymphoma

keyword
https://www.readbyqxmd.com/read/29769456/machine-learning-based-texture-analysis-of-contrast-enhanced-mr-imaging-to-differentiate-between-glioblastoma-and-primary-central-nervous-system-lymphoma
#1
Akira Kunimatsu, Natsuko Kunimatsu, Koichiro Yasaka, Hiroyuki Akai, Kouhei Kamiya, Takeyuki Watadani, Harushi Mori, Osamu Abe
PURPOSE: Although advanced MRI techniques are increasingly available, imaging differentiation between glioblastoma and primary central nervous system lymphoma (PCNSL) is sometimes confusing. We aimed to evaluate the performance of image classification by support vector machine, a method of traditional machine learning, using texture features computed from contrast-enhanced T1 -weighted images. METHODS: This retrospective study on preoperative brain tumor MRI included 76 consecutives, initially treated patients with glioblastoma (n = 55) or PCNSL (n = 21) from one institution, consisting of independent training group (n = 60: 44 glioblastomas and 16 PCNSLs) and test group (n = 16: 11 glioblastomas and 5 PCNSLs) sequentially separated by time periods...
May 16, 2018: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/29760948/the-diagnosis-and-treatment-of-primary-vitreoretinal-lymphoma-a-review
#2
REVIEW
Jose S Pulido, Patrick B Johnston, Grzegorz S Nowakowski, Allessia Castellino, Harish Raja
Background: To describe the recent diagnostic and treatment options for the most predominant form of primary vitreoretinal lymphoma (PVRL), namely diffuse large B cell lymphoma. This is mainly based on the experience at the Mayo Clinic as well as a partial review of the literature. MYD88 L265P mutation is seen in about 80% of cases; therefore, a polymerase chain reaction for this mutation helps in making the diagnosis that has been notoriously difficult to make. Local therapy using intravitreal methotrexate and rituximab has been very helpful in the treatment of the local disease...
2018: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/29744624/a-rare-case-of-paediatric-primary-central-nervous-system-lymphoma-treated-with-high-dose-methotrexate-and-rituximab-based-chemoimmunotherapy-and-whole-brain-radiotherapy-followed-by-tumour-bed-boost-with-three-dimensional-conformal-radiation-technique
#3
Narayan Adhikari, Ahitagni Biswas, Sameer Bakhshi, Gaurav Khanna, Vaishali Suri
BACKGROUND: Primary central nervous system lymphomas (PCNSL) are rare in the paediatric population. CLINICAL CASE: A 12-year-old boy presented to our clinic with complaints of multiple episodes of generalised tonic-clonic seizures for 1 year and gradual loss of vision in both eyes for 3 months. Baseline magnetic resonance imaging (MRI) of the brain showed a large (7.2 × 7 cm) enhancing soft tissue lesion in the right frontal lobe causing mass effect and midline shift...
May 9, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29741421/treatment-of-newly-diagnosed-primary-central-nervous-system-lymphoma-current-and-emerging-therapies
#4
Tarsheen K Sethi, Nishitha M Reddy
Primary central nervous lymphoma (PCNSL) is a rare extra-nodal subtype of non-Hodgkin lymphoma and most cases are of diffuse large B-cell lymphoma histology with an aggressive presentation. The treatment of PCNSL has evolved over the years from radiation alone to multi-agent chemotherapy with the goal of minimizing long-term toxicity. Recent studies have evaluated autologous stem cell transplant as consolidation in eligible patients with success. The prognosis of relapsed disease remains poor and hence the emphasis is on effective and less toxic frontline strategies...
May 9, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29741279/testing-physical-function-in-children-undergoing-intense-cancer-treatment-a-respect-feasibility-study
#5
Martin K F Nielsen, Jesper F Christensen, Thomas L Frandsen, Troels Thorsteinsson, Lars B Andersen, Karl B Christensen, Jacob Nersting, Marianne Faber, Kjeld Schmiegelow, Hanne B Larsen
BACKGROUND: The physical function of children with cancer is reduced during treatment, which can compromise the quality of life and increase the risk of chronic medical conditions. The study, "REhabilitation, including Social and Physical activity and Education in Children and Teenagers with cancer" (Clinicaltrials.gov: NCT01772862) examines the efficacy of multimodal rehabilitation strategies introduced at cancer diagnosis. This article addresses the feasibility of and obstacles to testing physical function in children with cancer...
May 9, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29740389/a-rare-case-of-composite-dural-extranodal-marginal-zone-lymphoma-and-chronic-lymphocytic-leukemia-small-lymphocytic-lymphoma
#6
REVIEW
Mark Bustoros, Benjamin Liechty, David Zagzag, Cynthia Liu, Timothy Shepherd, Deborah Gruber, Bruce Raphael, Dimitris G Placantonakis
Background: Primary extranodal marginal zone lymphoma (MZL) of the dura is a rare neoplastic entity in the central nervous system (CNS). Methods: We used literature searches to identify previously reported cases of primary dural MZL. We also reviewed clinical, pathologic, and radiographic data of an adult patient with concurrent dural MZL and chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). Results: We identified 104 cases of dural MZL in the literature...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29732319/epstein-barr-virus-in-gliomas-cause-association-or-artifact
#7
REVIEW
Saghir Akhtar, Semir Vranic, Farhan Sachal Cyprian, Ala-Eddin Al Moustafa
Gliomas are the most common malignant brain tumors and account for around 60% of all primary central nervous system cancers. Glioblastoma multiforme (GBM) is a grade IV glioma associated with a poor outcome despite recent advances in chemotherapy. The etiology of gliomas is unknown, but neurotropic viruses including the Epstein-Barr virus (EBV) that is transmitted via salivary and genital fluids have been implicated recently. EBV is a member of the gamma herpes simplex family of DNA viruses that is known to cause infectious mononucleosis (glandular fever) and is strongly linked with the oncogenesis of several cancers, including B-cell lymphomas, nasopharyngeal, and gastric carcinomas...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29724302/-value-of-minimum-apparent-diffusion-coefficient-in-peritumoral-edema-in-the-differential-diagnosis-between-primary-central-nervous-system-lymphoma-and-glioblastoma
#8
Ming Ge Li, Zhi Ye Chen, Gang Liu, Hua Feng Xiao, Xin Jing Chen, Xin Lou, Lin Ma
Objective To evaluate the role of minimum apparent diffusion coefficient(MinADC) values in peritumoral edema based on magnetic resonance diffusion weighted imaging in the differential diagnosis between primary central nervous system lymphoma(PCNSL) and glioblastoma(GBM).Methods ADC values in peritumoral edema were measured in 16 patients with PCNSL(diffuse large B cell lymphoma) and 31 patients with GBM(WHO grade 4) confirmed by pathology.Regions of interests were manually drawn on ADC maps on peritumoral edema regions to obtain the MinADC value...
April 28, 2018: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/29697005/primary-breast-diffuse-large-b-cell-lymphoma-treatment-strategies-and-patterns-of-failure
#9
Ethan B Ludmir, Sarah A Milgrom, Chelsea C Pinnix, Jillian R Gunther, Jason Westin, Yasuhiro Oki, Luis E Fayad, L Jeffrey Medeiros, Bouthaina S Dabaja, Loretta J Nastoupil
Treatment strategies and outcomes were assessed in 25 patients with primary breast diffuse large B-cell lymphoma (PB-DLBCL) treated between 1995 and 2016. We specifically investigated the timing of recurrence, and the roles of radiotherapy (RT) and central nervous system prophylaxis (CNS PPX). Fifty-two percent of patients received RT, and 28% received CNS PPX. Fourteen patients (56%) experienced recurrence, with 76% of relapses occurring ≥24 months after diagnosis, in contrast to reports supporting the use of 24-month event-free survival as a surrogate endpoint in the general DLBCL population...
April 26, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29682187/prognostic-value-of-early-18f-fdg-pet-scanning-evaluation-in-immunocompetent-primary-cns-lymphoma-patients
#10
Rudy Birsen, Estelle Blanc, Lise Willems, Barbara Burroni, Marielle Legoff, Emmanuelle Le Ray, Sylvain Pilorge, Sawsen Salah, Aude Quentin, Benedicte Deau, Patricia Franchi, Marguerite Vignon, Laurence Mabille, Charles Nguyen, Yioula Kirova, Pascale Varlet, Myriam Edjlali, Edouard Dezamis, Khê Hoang-Xuan, Carole Soussain, Caroline Houillier, Diane Damotte, Johan Pallud, Didier Bouscary, Jerome Tamburini
Primary central nervous system lymphoma (PCNSL) is a rare topographic variant of diffuse large B-cell lymphoma (DLBCL). While prognostic scales are useful in clinical trials, no dynamic prognostic marker is available in this disease. We report here the prognostic value of early metabolic response by 18F-FDG PET scanner (PET) in 25 newly diagnosed immunocompetent PCNSL patients. Induction treatment consisted of four cycles of Rituximab, Methotrexate and Temozolamide (RMT). Based on patient's general condition, consolidation by high-dose Etoposide and Aracytine was given to responding patients...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29678710/pediatric-type-follicular-lymphoma-in-the-dura-a-case-report-and-literature-review
#11
Junya Yamaguchi, Seiichi Kato, Eri Iwata, Kosuke Aoki, Ryusuke Kabeya, Atsushi Natsume, Toshihiko Wakabayashi
BACKGROUND: Primary central nervous system lymphoma (PCNSL) is a relatively common tumor of the central nervous system. Although PCNSLs generally arise from the parenchyma, lymphomas arising primarily from the dura are termed dural lymphomas (DL). Mucosa-associated lymphoid tissue is the most unique histological feature of DL. Due to its rarity, clinical characteristics and treatments for DL have not been fully elucidated to date. CASE DESCRIPTION: A 31-year-old man with no past medical history presented with numbness in his left upper limb...
April 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29676363/lymphomatoid-granulomatosis-a-case-series-from-south-india
#12
Elanthenral Sigamani, Jagan Chandramohan, Sheila Nair, Geeta Chacko, Meera Thomas, Leni Grace Mathew, Susanne Pulimood, Marie Therese Manipadam
Context: Lymphomatoid granulomatosis (LYG) is a rare B-lymphoproliferative disorder characterised by an angiocentric and angiodestructive pattern along with Epstein - Barr virus (EBV) association. It is one of the diagnostic challenges in lymphoma pathology. Deregulation of EBV immune surveillance is one of the narrated hypotheses in the literature. Extrapulmonary manifestations are rare with LYG. Morphological grading is done based on the number of EBV-positive B cells, which is useful to strategize treatment protocol...
April 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29668860/alectinib-versus-chemotherapy-in-crizotinib-pretreated-anaplastic-lymphoma-kinase-alk-positive-non-small-cell-lung-cancer-results-from-the-phase-iii-alur-study
#13
S Novello, J Mazières, I-J Oh, J de Castro, M R Migliorino, Å Helland, R Dziadziuszko, F Griesinger, A Kotb, A Zeaiter, A Cardona, B Balas, H K Johannsdottir, A Das-Gupta, J Wolf
Background: This is the first trial to directly compare efficacy and safety of alectinib versus standard chemotherapy in advanced/metastatic anaplastic lymphoma kinase (ALK)-positive non-small-cell lung cancer (NSCLC) patients who have progressed on, or were intolerant to, crizotinib. Patients and methods: ALUR (MO29750; NCT02604342) was a randomized, multicenter, open-label, phase III trial of alectinib versus chemotherapy in advanced/metastatic anaplastic lymphoma kinase (ALK)-positive NSCLC patients previously treated with platinum-based doublet chemotherapy and crizotinib...
April 14, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29665911/-clinical-analysis-of-refractory-primary-central-nervouse-system-lymphoma-treated-with-high-dose-mtx-based-chemotherapy-and-haploidentical-hematopoietic-stem-cell-infusion
#14
Juan Liu, Wan-Jun Sun, Xiao-Qin Xi, Xiao-Mei Huang, Xiao-Xi Li, Jiao Xia, Yuan-Yuan Qu
OBJECTIVE: To investigate the efficacy and safety of high-dose methotrexate-based chemotherapy combined with granulocyte-colony stimulating factor (G-CSF)-mobilized family related haploidentical donor peripheral blood hematopoietic stem cell (G-PBHSC) infusion for the treatment of patients with refractory primary central nervouse system lymphoma (PCNSL). METHODS: Three patients with refractory PCNSL were treated in Department of Hematology of the General Hospital of the PLA's Rocket Force from March 2014 to September 2015...
April 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/29662865/successful-rapid-drug-desensitization-to-methotrexate-in-a-patient-with-primary-central-nervous-system-lymphoma
#15
Kyung Mee Song, Junghwan Lee, Ji Hyun Park, So-Young Park, Tae-Bum Kim, Cheolwon Suh
No abstract text is available yet for this article.
March 2018: Blood Research
https://www.readbyqxmd.com/read/29662531/cystic-brain-metastases-in-alk-rearranged-non-small-cell-lung-cancer
#16
REVIEW
Guilherme Nader Marta, Renata Rodrigues da Cunha Colombo Bonadio, Renata Eiras Martins, Henrique Bortot Zuppani, Gilberto de Castro
The central nervous system (CNS) is a common site of disease progression in patients with non-small-cell lung cancer (NSCLC) with anaplastic lymphoma kinase (ALK)-rearrangement treated with crizotinib. Cystic brain metastases (CBM) have been recently identified as one possible variant of this disease. An illustrative case report is presented along with a literature review performed in order to track relevant papers about CBM in ALK-rearranged NSCLC, including possible pathophysiology, differential diagnosis and treatment options for this condition...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29660011/craniotomy-and-survival-for-primary-central-nervous-system-lymphoma
#17
Ali I Rae, Amol Mehta, Michael Cloney, Connor J Kinslow, Tony J C Wang, Govind Bhagat, Peter D Canoll, George J Zanazzi, Michael B Sisti, Sameer A Sheth, E Sander Connolly, Guy M McKhann, Jeffrey N Bruce, Fabio M Iwamoto, Adam M Sonabend
BACKGROUND: Cytoreductive surgery is considered controversial for primary central nervous system lymphoma (PCNSL). OBJECTIVE: To investigate survival following craniotomy or biopsy for PCNSL. METHODS: The National Cancer Database-Participant User File (NCDB, n = 8936), Surveillance, Epidemiology, and End Results Program (SEER, n = 4636), and an institutional series (IS, n = 132) were used. We retrospectively investigated the relationship between craniotomy, prognostic factors, and survival for PCNSL using case-control design...
April 4, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29656000/primary-central-nervous-system-lymphoma-at-the-cerebellopontine-angle-mimicking-a-trigeminal-schwannoma-a-unique-case-report-and-literature-review
#18
Vijay Seevaratnam, Yingda Li, Sun Loong Keegan Lee, Gemma Olsson
Primary central nervous system lymphoma (PCNSL) is an uncommon extranodal manifestation of non-Hodgkin's lymphoma with those presenting at the cerebellopontine angle (CPA) being rare presentations with limited reported cases in the literature. We report a 60-year old female presenting with PCNSL of the left CPA radiologically mimicking a trigeminal schwannoma with corresponding clinical signs. Imaging showed a left CPA lesion that was biopsied and confirmed as diffuse large B-cell lymphoma. Given its rarity, PCNSL should be considered in the differential diagnosis for all CPA tumours...
April 11, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29629945/clonal-evolution-in-primary-diffuse-large-b-cell-lymphoma-of-the-central-nervous-system
#19
Julia Garcia-Reyero, Nerea Martinez Magunacelaya, Ainara Gonzalez Pereña, Sara Marcos Gonzalez, Nuria Teran-Villagra, Ainara Azueta, Ana Batlle, Sonia Gonzalez de Villambrosia, Jose Revert Arce, Santiago Montes-Moreno
Primary diffuse large B-cell lymphoma (DLBCL) of the central nervous system (CNS) is an aggressive subtype of DLBCL with characteristic clinicopathologic features. Relapse outside the CNS involving extranodal locations has been found in a fraction of cases (16%). Here we describe a case of DLBCL arising in the CNS that relapsed 18 months after the initial diagnosis in the testis and bilateral adrenal glands. Both tumors showed equivalent morphology, phenotype, cytogenetic features, and clonal relationship. Somatic mutation analysis by next generation sequencing demonstrated MYD88L265P mutation in both tumors and de novo CD79B Y196S mutation exclusive to the relapse...
April 7, 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29626238/primary-central-nervous-system-lymphoma-and-atypical-glioblastoma-differentiation-using-radiomics-approach
#20
Hie Bum Suh, Yoon Seong Choi, Sohi Bae, Sung Soo Ahn, Jong Hee Chang, Seok-Gu Kang, Eui Hyun Kim, Se Hoon Kim, Seung-Koo Lee
OBJECTIVES: To evaluate the diagnostic performance of magnetic resonance (MR) radiomics-based machine-learning algorithms in differentiating primary central nervous system lymphoma (PCNSL) from non-necrotic atypical glioblastoma (GBM). METHODS: Seventy-seven patients (54 individuals with PCNSL and 23 with non-necrotic atypical GBM), diagnosed from January 2009 to April 2017, were enrolled in this retrospective study. A total of 6,366 radiomics features, including shape, volume, first-order, texture, and wavelet-transformed features, were extracted from multi-parametric (post-contrast T1- and T2-weighted, and fluid attenuation inversion recovery images) and multiregional (enhanced and non-enhanced) tumour volumes...
April 6, 2018: European Radiology
keyword
keyword
59502
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"