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https://www.readbyqxmd.com/read/29652940/functionality-of-cow-milk-naturally-enriched-with-polyunsaturated-fatty-acids-and-polyphenols-in-diets-for-diabetic-rats
#1
Emerson H Yoshimura, Nadine W Santos, Erica Machado, Bruna C Agustinho, Lucelia M Pereira, Sílvia C de Aguiar, Anacharis B Sá-Nakanishi, Cecília E Mareze-da-Costa, Lucia M Zeoula
The increasing incidence of diabetes mellitus is becoming a serious threat to human health in various parts of the world. Studies with dairy products have shown a potential beneficial effect against diabetes. This experiment evaluated the supplementation of milk naturally enriched with polyunsaturated fatty acids (PUFA) and polyphenols in rats with streptozotocin-induced diabetes. Forty male 28-day-old Wistar rats were distributed in four experimental treatments of diabetic animals (streptozotocin induction) and a normal group (non-induced)...
2018: PloS One
https://www.readbyqxmd.com/read/29649537/anti-obesity-effects-and-changes-of-colonic-transcriptome-by-sodium-alginate-on-high-fat-diet-induced-obese-mice
#2
Xiong Wang, Fang Liu, Yuan Gao, Chang-Hu Xue, R W Li, Qing-Juan Tang
Human obesity and overweight, caused by accumulated of fat, is the most commonly phenomenon from all over the world, especially in Western countries and Chinese mainland during the past three decades. Sodium Alginate, a polysaccharide extracted from brown seaweeds, has been proved its strong ability on body weight loss and anti-inflammatory response. However, no studies have been explored the effects of Sodium Alginate on colonic transcriptome, especially in obese individuals. Therefore, the current study was designed to detect whether Sodium Alginate could remit obesity and ease chronic metabolism disease through strengthening the bio-functionality of the lower intestine, particularly in colon...
April 9, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29643769/the-role-of-physical-exercise-to-improve-the-browning-of-white-adipose-tissue-via-pomc-neurons
#3
REVIEW
Kellen C da Cruz Rodrigues, Rodrigo M Pereira, Thaís D P de Campos, Rodrigo F de Moura, Adelino S R da Silva, Dennys E Cintra, Eduardo R Ropelle, José R Pauli, Michel B de Araújo, Leandro P de Moura
Obesity is a public health issue that affects more than 600 million adults worldwide. The disease is characterized by fat accumulation, mainly in the abdominal area. The human body is mainly composed of two types of adipose tissue: white adipose tissue (WAT) and brown adipose tissue (BAT); however, the browning process generates a different type of brown fat-like adipocyte in WAT, which similar to BAT has thermogenic capacity by activating UCP-1. The hypothalamic arcuate nucleus plays an important role in WAT browning via POMC neurons, which are influenced by synergistic insulin and leptin signaling...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29643685/unilateral-brown-fat-suppression-on-fdg-pet-ct-detecting-sympathetic-denervation
#4
Saurabh Arora, Nishikant Avinash Damle, K Sreenivasa Reddy, Girish Kumar Parida, Abhinav Singhal, Sreedharan Thankarajan Arunraj, Chandrasekhar Bal, Roma Singh, Shobhana Raju, Dhritiman Chakraborty
We present here a case of primitive neuroectodermal tumor (PNET) who initially presented with involvement of the right 3rd rib and underwent neoadjuvant chemotherapy, rib excision, and adjuvant chemoradiotherapy and later underwent posterolateral thoracotomy, pleural nodule excision, and the right 11th rib metastatic lesion excision. Follow-up 18 F-FDG PET/CT/computed tomography revealed unilateral brown fat suppression in the form of decreased metabolic uptake in the ipsilateral cervical, axillary, and paravertebral brown fat as compared to metabolically active contralateral brown fat, likely due to paravertebral sympathetic chain damage...
April 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29642370/global-transcriptome-analysis-of-brown-adipose-tissue-of-diet-induced-obese-mice
#5
Jingyi Cao, Qi Zhu, Lin Liu, Bradley J Glazier, Benjamin C Hinkel, Chun Liang, Haifei Shi
Consumption of a high-fat diet (HFD) promotes the development of obesity, a disease resulting from an imbalance between energy intake and energy expenditure. Brown adipose tissue (BAT) has thermogenic capacity that burns calories to produce heat, and it is a potential target for the treatment and prevention of obesity. There is limited information regarding the impact of HFD on the BAT transcriptome. We hypothesized that HFD-induced obesity would lead to transcriptional regulation of BAT genes. RNA sequencing was used to generate global transcriptome profiles from BAT of lean mice fed with a low-fat diet (LFD) and obese mice fed with a HFD...
April 6, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29630153/successful-management-of-congenital-infantile-fibrosarcoma-presenting-as-large-non-healing-buttock-ulceration
#6
Madeleine G Sowash, Karen Itumeleng Mosojane, Alan R Anderson, Carrie L Kovari, Victoria L Williams
A two-year-old boy presented with a large, non-healing ulceration on his left buttock, which was originally noted as a brown patch present at birth. Punch skin biopsy was performed and histopathology revealed an atypical, pleomorphic, spindled proliferation in whorled fascicles replacing the dermis and trapping fat in the subcutis, consistent with a diagnosis of congenital/infantile fibrosarcoma. No evidence of metastatic spread was seen on imaging. The tumor was initially deemed unresectable owing to extent of local invasion...
February 15, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/29629919/hibernoma-mimicking-atypical-lipomatous-tumor-64-cases-of-a-morphologically-distinct-subset
#7
Youssef Al Hmada, Inga-Marie Schaefer, Christopher D M Fletcher
Hibernoma is a benign adipocytic tumor with predilection for subcutaneous tissue of the thigh, upper trunk, and neck of middle-aged adults. 11q13 rearrangement resulting in MEN1/AIP codeletion is characteristic. Hibernomas are composed, in varying proportions, of brown fat cells, mature adipocytes, and microvacuolated lipoblast-like cells. Examples containing predominantly multivacuolated lipoblast-like cells are uncommon and distinction from atypical lipomatous tumor (ALT) is important for clinical management...
April 6, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29626186/de-novo-reconstruction-of-human-adipose-transcriptome-reveals-conserved-lncrnas-as-regulators-of-brown-adipogenesis
#8
Chunming Ding, Yen Ching Lim, Sook Yoong Chia, Arcinas Camille Esther Walet, Shaohai Xu, Kinyui Alice Lo, Yanling Zhao, Dewen Zhu, Zhihui Shan, Qingfeng Chen, Melvin Khee-Shing Leow, Dan Xu, Lei Sun
Obesity has emerged as an alarming health crisis due to its association with metabolic risk factors such as diabetes, dyslipidemia, and hypertension. Recent work has demonstrated the multifaceted roles of lncRNAs in regulating mouse adipose development, but their implication in human adipocytes remains largely unknown. Here we present a catalog of 3149 adipose active lncRNAs, of which 909 are specifically detected in brown adipose tissue (BAT) by performing deep RNA-seq on adult subcutaneous, omental white adipose tissue and fetal BATs...
April 6, 2018: Nature Communications
https://www.readbyqxmd.com/read/29624417/consumption-of-green-coffee-and-the-risk-of-chronic-diseases
#9
Nevin Sanlİer, Azize Atİk, İlker Atİk
Green coffee contains macro nutrients such as carbohydrates, protein, fat, as well as minor components such as caffeine, trigonelin and chlorogenic acid. Phenolics, chlorogenic acids and brown pigments are sources of natural antixodants. High polypehonic materials found in green coffee and especially chlorogenic acid in it have an important place. It is considered that; green coffee has effects on body mass, blood glucose and lipid levels, blood pressure, prevention from cardiovascular diseases which is based on chlorogenic acid consisting antioxidant activity...
April 6, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29618935/metabolic-profiling-of-follistatin-overexpression-a-novel-therapeutic-strategy-for-metabolic-diseases
#10
Rajan Singh, Shehla Pervin, Se-Jin Lee, Alan Kuo, Victor Grijalva, John David, Laurent Vergnes, Srinivasa T Reddy
Background: Follistatin (Fst) promotes brown adipocyte characteristics in adipose tissues. Methods: Abdominal fat volume (CT scan), glucose clearance (GTT test), and metabolomics analysis (mass spectrometry) of adipose tissues from Fst transgenic (Fst-Tg) and wild type (WT) control mice were analyzed. Oxygen consumption (Seahorse Analyzer) and lipidomics (gas chromatography) was analyzed in 3T3-L1 cells. Results: Fst-Tg mice show significant decrease in abdominal fat content, increased glucose clearance, improved plasma lipid profiles and significant changes in several conventional metabolites compared to the WT mice...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/29617645/mitochondria-bound-to-lipid-droplets-have-unique-bioenergetics-composition-and-dynamics-that-support-lipid-droplet-expansion
#11
Ilan Y Benador, Michaela Veliova, Kiana Mahdaviani, Anton Petcherski, Jakob D Wikstrom, Essam A Assali, Rebeca Acín-Pérez, Michaël Shum, Marcus F Oliveira, Saverio Cinti, Carole Sztalryd, William D Barshop, James A Wohlschlegel, Barbara E Corkey, Marc Liesa, Orian S Shirihai
Mitochondria associate with lipid droplets (LDs) in fat-oxidizing tissues, but the functional role of these peridroplet mitochondria (PDM) is unknown. Microscopic observation of interscapular brown adipose tissue reveals that PDM have unique protein composition and cristae structure and remain adherent to the LD in the tissue homogenate. We developed an approach to isolate PDM based on their adherence to LDs. Comparison of purified PDM to cytoplasmic mitochondria reveals that (1) PDM have increased pyruvate oxidation, electron transport, and ATP synthesis capacities; (2) PDM have reduced β-oxidation capacity and depart from LDs upon activation of brown adipose tissue thermogenesis and β-oxidation; (3) PDM support LD expansion as Perilipin5-induced recruitment of mitochondria to LDs increases ATP synthase-dependent triacylglyceride synthesis; and (4) PDM maintain a distinct protein composition due to uniquely low fusion-fission dynamics...
April 3, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/29615315/the-use-of-buccal-fat-pad-in-surgical-treatment-of-krokodil-drug-related-osteonecrosis-of-maxilla
#12
Koryun Hakobyan, Yuri Poghosyan, Aram Kasyan
'Krokodil' is the street name of a new synthetic drug mixture. It is a light brown liquid that is used intravenously without previous purification. Osteonecrosis of the jaw (ONJ) is a common complication among Krokodil users. Krokodil drug-related ONJ presents as alveolar process exposure in the oral cavity. Surgery is the main method for treatment of Krokodil drug-related ONJ patients. In a study by Poghosyan et al., no cases of recurrence were seen after surgery on the maxilla, but 38% of cases (8/21) developed an oroantral communication after surgical treatment for maxillary osteonecrosis (Poghosyan et al...
March 20, 2018: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29614883/bergamottin-inhibits-adipogenesis-in-3t3-l1-cells-and-weight-regulation-in-diet-induced-obese-mice
#13
Jeong-Hyeon Ko, Dongwoo Nam, Jae-Young Um, Sang Hoon Jung, Kwang Seok Ahn
Obesity is a serious and increasing health problem worldwide, and the inhibition of adipogenesis is considered to be a potential therapeutic target for it. Bergamottin (BGM), a component of grapefruit juice, has been reported to regulate lipolysis. However, the physiological role of BGM in obesity has not been evaluated so far. In the present study, we investigated the effects of BGM on obesity in 3T3-L1 cells and in mice fed a high-fat diet (HFD). BGM inhibited adipogenic differentiation of 3T3-L1 cells along with a significant decrease in the lipid content by downregulating the expression of two critical adipogenic factors, CCAAT enhancer-binding protein-alpha (C/EBP[Formula: see text]) and peroxisome proliferator activated receptor-gamma (PPAR[Formula: see text])...
April 4, 2018: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29611149/effect-of-ambient-temperature-on-the-proliferation-of-brown-adipocyte-progenitors-and-endothelial-cells-during-postnatal-bat-development-in-syrian-hamsters
#14
Kazuki Nagaya, Yuko Okamatsu-Ogura, Junko Nio-Kobayashi, Shohei Nakagiri, Ayumi Tsubota, Kazuhiro Kimura
In Syrian hamsters, brown adipose tissue (BAT) develops postnatally through the proliferation and differentiation of brown adipocyte progenitors. In the study reported here, we investigated how ambient temperature influenced BAT formation in neonatal hamsters. In both hamsters raised at 23 or 30 °C, the interscapular fat changed from white to brown coloration in an age-dependent manner and acquired the typical morphological features of BAT by day 16. However, the expression of uncoupling protein 1, a brown adipocyte marker, and of vascular endothelial growth factor α were lower in the group raised at 30 °C than in that raised at 23 °C...
April 2, 2018: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/29609280/-advances-in-the-research-of-relationship-between-brown-or-beige-fat-and-hypermetabolism-after-severe-burn
#15
M Zhang, Y Liu, X Zhang
Hypermetabolism is one of the remarkable characteristics of burn injury. Prolonged hypermetabolism causes insufficient energy supply, which leads to delayed wound healing, immune system dysfunction, increased infection rate, and multi-organ failure. In recent years, it is concerned that the activation of brown or beige adipose tissue may be related to hypermetabolism in severe burn patients. Brown or beige adipose tissue could be regulated by stress hormones and some cytokines which increase and persist in high level for several months after severe burn...
March 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29606738/effect-of-formulation-and-baking-conditions-on-the-structure-and-development-of-non-enzymatic-browning-in-biscuit-models-using-images
#16
Gabriel A Leiva-Valenzuela, Marcela Quilaqueo, Daniela Lagos, Danilo Estay, Franco Pedreschi
The aim of this research was to determine the effect of composition (dietary fiber = DF, fat = F, and gluten = G) and baking time on the target microstructural parameters that were observed using images of potato and wheat starch biscuits. Microstructures were studied Scanning Electron Microscope (SEM). Non-enzymatic browning (NEB) was assessed using color image analysis. Texture and moisture analysis was performed to have a better understanding of the baking process. Analysis of images revealed that the starch granules retained their native form at the end of baking, suggesting their in complete gelatinization...
April 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29605715/a-computational-biology-approach-of-a-genome-wide-screen-connected-mirnas-to-obesity-and-type-2-diabetes
#17
Pascal Gottmann, Meriem Ouni, Sophie Sausenthaler, Julian Roos, Laura Stirm, Markus Jähnert, Anne Kamitz, Nicole Hallahan, Wenke Jonas, Andreas Fritsche, Hans-Ulrich Häring, Harald Staiger, Matthias Blüher, Pamela Fischer-Posovszky, Heike Vogel, Annette Schürmann
OBJECTIVE: Obesity and type 2 diabetes (T2D) arise from the interplay between genetic, epigenetic, and environmental factors. The aim of this study was to combine bioinformatics and functional studies to identify miRNAs that contribute to obesity and T2D. METHODS: A computational framework (miR-QTL-Scan) was applied by combining QTL, miRNA prediction, and transcriptomics in order to enhance the power for the discovery of miRNAs as regulative elements. Expression of several miRNAs was analyzed in human adipose tissue and blood cells and miR-31 was manipulated in a human fat cell line...
March 15, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29599711/administration-of-the-antioxidant-n-acetyl-cysteine-in-pregnant-mice-has-long-term-positive-effects-on-metabolic-and-behavioral-endpoints-of-male-and-female-offspring-prenatally-exposed-to-a-high-fat-diet
#18
Alessandra Berry, Veronica Bellisario, Pamela Panetta, Carla Raggi, Maria C Magnifico, Marzia Arese, Francesca Cirulli
A growing body of evidence suggests the consumption of high-fat diet (HFD) during pregnancy to model maternal obesity and the associated increase in oxidative stress (OS), might act as powerful prenatal stressors, leading to adult stress-related metabolic or behavioral disorders. We hypothesized that administration of antioxidants throughout gestation might counteract the negative effects of prenatal exposure to metabolic challenges (maternal HFD feeding during pregnancy) on the developing fetus. In this study, female C57BL/6J mice were fed HFD for 13 weeks (from 5-weeks of age until delivery) and were exposed to the N-acetyl-cysteine (NAC) antioxidant from 10-weeks of age until right before delivery...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29597239/mammary-hibernoma-a-case-report-of-a-rare-disease
#19
Eduardo Henrique Cunha Neves Filho, Geórgia de Aguiar Feitosa Lima, Ângelo Roncalli Melo Alves, Valdenrique Macêdo de Sousa, Maria do Perpétuo Socorro Saldanha da Cunha
Mammary hibernomas are extremely rare benign tumors composed of brown fat cells, with only five cases previously reported in the literature. We report the case of a 42-year-old female patient with a painless growing mass in her right breast. A partial mastectomy was performed, and the diagnosis of hibernoma was confirmed by the histological features and the immunohistochemical profile. Although hibernoma is a benign tumor, its main differential diagnoses include aggressive lesions, making the accurate diagnosis essential to provide adequate care to the patient...
March 29, 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29596616/vegf-and-vegfb-play-balancing-roles-in-adipose-differentiation-gene-expression-and-function
#20
Honghong Jin, Dan Li, Xutong Wang, Jia Jia, Yang Chen, Yapeng Yao, Chunlan Zhao, Xiaodan Lu, Shujie Zhang, Jacques Togo, Yan Ji, Luqing Zhang, Xuechao Feng, Yaowu Zheng
Obesity is the results of abnormal adipose development and energy metabolism. Using VEGFB knockout and inducible VEGF down regulation mouse models, we have shown that VEGFB inactivation caused expansion of white adipose, whitening of brown adipose, increase of fat accumulation and reduction of energy consumption. At the same time, expression of the white adipose-associated genes was increased and brown adipose-associated genes decreased. VEGF repression, in contrary, induced brown adipose expansion and brown adipocytes development in white adipose, increased energy expenditure, up regulated brown adipose-associated genes and down regulated white adipose-associated genes...
March 27, 2018: Endocrinology
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