keyword
MENU ▼
Read by QxMD icon Read
search

DM2

keyword
https://www.readbyqxmd.com/read/28328990/gut-microbiome-analysis-of-type-2-diabetic-patients-from-the-chinese-minority-ethnic-groups-the-uygurs-and-kazaks
#1
Ye Wang, Xin Luo, Xinmin Mao, Yicun Tao, Xinjian Ran, Haixia Zhao, Jianhui Xiong, Linlin Li
The gut microbiome may have an important influence on the development of diabetes mellitus type 2 (DM2). To better understand the DM2 pandemic in ethnic minority groups in China, we investigated and compared the composition and richness of the gut microbiota of healthy, normal glucose tolerant (NGT) individuals and DM2 patients from two ethnic minority groups in Xinjiang, northwest China, the Uygurs and Kazaks. The conserved V6 region of the 16S rRNA gene was amplified by PCR from the isolated DNA. The amplified DNA was sequenced and analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/28325497/prognostic-factors-of-weight-loss-after-sleeve-gastrectomy-multi-centre-study-in-spain-and-portugal
#2
Raquel Sanchez Santos, Ricard Corcelles, Ramón Vilallonga Puy, Salvadora Delgado Rivilla, José Vicente Ferrer, Javier Foncillas Corvinos, Carlos Masdevall Noguera, Maria Socas Macias, Pedro Gomes, Carmen Balague Ponz, Jorge de Tomas Palacios, Sergio Ortiz Sebastian, Andrés Sanchez Pernaute, José Julián Puche Pla, Fátima Sabench Pereferrer, Julen Abasolo Vega, Xavier Suñol Sala, Ana Garcia Navarro, Carlos Duran Escribano, Norberto Cassinello Fernandez, Nieves Perez, José Antonio Gracia Solanas, Francisca Garcia-Moreno Nisa, Alberto Hernández Matias, Víctor Valentí Azcarate, José Eduardo Perez Folques, Inmaculada Navarro Garcia, Eduardo Dominguez-Adame Lanuza, Sagrario Martinez Cortijo, Jesús González Fernández
INTRODUCTION: Sleeve gastrectomy (SG) has become a technique in its own right although a selective or global indication remains controversial. The weight loss data at 5 years are heterogeneous. The aim of the study is to identify possible prognostic factors of insufficient weight loss after SG. METHODS: A SG retrospective multicenter study of more than one year follow-up was performed. Failure is considered if EWL>50%. Univariate and multivariate study of Cox regression were performed to identify prognostic factors of failure of weight loss at 1, 2 and 3 years of follow up...
March 18, 2017: Cirugía Española
https://www.readbyqxmd.com/read/28321519/cardiac-autonomic-function-in-type-1-and-type-2-myotonic-dystrophy
#3
Piotr Bienias, Anna Łusakowska, Michał Ciurzyński, Zuzanna Rymarczyk, Katarzyna Irzyk, Michał Konwerski, Kamil Ciąpała, Paweł Kowalski, Anna Kamińska, Piotr Pruszczyk
OBJECTIVE: The aim of this study was to evaluate cardiac autonomic nervous system function using Holter-derived and standard electrocardiographic parameters in patients with myotonic dystrophy (dystrophia myotonica, DM) and no clinically overt heart involvement. METHODS: Eighty-four DM patients without conditions potentially influencing cardiac autonomic function were enrolled in the study: 44 with DM type 1 and 40 with DM type 2 (mean age 34.9 ± 11.5 and 47...
March 20, 2017: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/28314656/safety-and-efficacy-of-a-basal-plus-regimen-with-insulin-glargine-and-insulin-glulisine-for-elderly-patients-with-high-cardiovascular-risk-and-type-2-diabetes-mellitus
#4
R Gómez-Huelgas, J Sabán-Ruiz, F J García-Román, N Quintela-Fernández, J M Seguí-Ripoll, M V Bonilla-Hernández, G Romero-Meliá
OBJECTIVES: To assess the safety and efficacy of a basal-plus (BP) regimen with insulin glargine (as basal insulin) and insulin glulisine (as prandial insulin) with the main meal for elderly patients with type 2 diabetes mellitus (DM2) and high cardiovascular risk, following standard clinical practice. PATIENTS AND METHODS: An observational, retrospective study was conducted in 21 centres of internal medicine in Spain. The study included patients aged 65 years or older with DM2, undergoing treatment with a BP regimen for 4 to 12 months before inclusion in the study and a diagnosis of cardiovascular disease or high cardiovascular risk...
March 14, 2017: Revista Clínica Española
https://www.readbyqxmd.com/read/28290890/-factors-associated-with-immediate-results-of-coronary-artery-bypass-grafting-in-patients-with-ischemic-heart-disease-in-the-presence-of-type-2-diabetes
#5
A N Sumin, N A Bezdenezhnyh, A V Bezdenezhnyh, S V Ivanov, O L Barbarash
OBJECTIVE: to elucidate factors associated with cardiovascular events (CVE) after coronary artery bypass grafting (CABG) depending on the presence of type 2 diabetes mellitus (DM2). MATERIAL AND METHODS: Medical records of 667 patients who underwent CABG during the period from 2006 to 2009 (317 patients with and 350 patients without DM2 and other disorders of glucose metabolism with comparable by sex, age and CABG characteristics) were analyzed retrospectively. The relationship of registered possible predictors with incidence of CVE was evaluated in a logistic regression model...
October 2016: Kardiologiia
https://www.readbyqxmd.com/read/28268961/a-novel-method-for-splice-sites-prediction-using-sequence-component-and-hidden-markov-model
#6
Elham Pashaei, Alper Yilmaz, Mustafa Ozen, Nizamettin Aydin
With increasing growth of DNA sequence data, it has become an urgent demand to develop new methods to accurately predict the genes. The performance of gene detection methods mainly depend on the efficiency of splice site prediction methods. In this paper, a novel method for detecting splice sites is proposed by using a new effective DNA encoding method and AdaBoost.M1 classifier. Our proposed DNA encoding method is based on multi-scale component (MSC) and first order Markov model (MM1). It has been applied to the HS3D dataset with repeated 10 fold cross validation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227168/a-novel-method-for-splice-sites-prediction-using-sequence-component-and-hidden-markov-model
#7
Elham Pashaei, Alper Yilmaz, Mustafa Ozen, Nizamettin Aydin, Elham Pashaei, Alper Yilmaz, Mustafa Ozen, Nizamettin Aydin, Nizamettin Aydin, Alper Yilmaz, Elham Pashaei, Mustafa Ozen
With increasing growth of DNA sequence data, it has become an urgent demand to develop new methods to accurately predict the genes. The performance of gene detection methods mainly depend on the efficiency of splice site prediction methods. In this paper, a novel method for detecting splice sites is proposed by using a new effective DNA encoding method and AdaBoost.M1 classifier. Our proposed DNA encoding method is based on multi-scale component (MSC) and first order Markov model (MM1). It has been applied to the HS3D dataset with repeated 10 fold cross validation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28210870/diabetes-related-burden-and-distress-in-people-with-diabetes-mellitus-at-primary-care-level-in-germany
#8
N Kuniss, T Rechtacek, C Kloos, U A Müller, J Roth, K Burghardt, G Kramer
AIMS: The importance of diabetes-related distress for the treatment of diabetes is emphasised in national and international guidelines recommending routinely screening for psychosocial problems. Data of investigations regarding diabetes-related distress on primary care are rare in Germany though most people with diabetes are treated without insulin therapy at primary care level. METHODS: Three hundred and forty-five people with diabetes mellitus type 2 (DM2, n = 336, 229 without and 107 with insulin therapy) and type 1 (DM1, n = 9) were interviewed with the PAID questionnaire in the period from 1 October 2015 to 31 December 2015 in a general practice...
February 16, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28202347/in-silico-design-chemical-synthesis-and-toxicological-evaluation-of-1-3-thiazolidine-2-4-dione-derivatives-as-ppar%C3%AE-agonists
#9
Diana Alemán-González-Duhart, Feliciano Tamay-Cach, José Correa-Basurto, Itzia Irene Padilla-Martínez, Samuel Álvarez-Almazán, Jessica Elena Mendieta-Wejebe
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors involved in the metabolism of lipids and carbohydrates. The exogenous ligands of these receptors are thiazolidinediones (TZDs), which are used to treat type 2 diabetes mellitus (DM2). However, drugs from this group produce adverse effects such as hepatic steatosis. Hence, the aim of this work was to design a set of small molecules that can activate the γ isoform of PPARs while minimizing the adverse effects. The derivatives were designed containing the polar head of TZD and an aromatic body, serving simultaneously as the body and tail...
February 12, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28198081/latent-autoimmune-diabetes-in-adults-lada-in-asian-and-european-populations
#10
REVIEW
Alok Kumar, Alberto de Leiva
Diabetes Mellitus (DM) is a chronic disorder caused by relative or absolute insulin deficiency and characterized by chronic hyperglycaemia. It is expected that by year 2025, 80% of all Type 2 Diabetic patients will be living in developing or low and middle income countries. Among Asians, there has been an overall increase in abdominal obesity however, the risk of diabetes in these populations starts at much lower body mass index (BMI) as compared to Caucasians. A significant proportion of diabetic patients with adult-onset, initially non-requiring insulin treatment, depicts diabetes-associated autoantibodies in their sera...
February 14, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28188264/immortalized-human-myotonic-dystrophy-muscle-cell-lines-to-assess-therapeutic-compounds
#11
Arandel Ludovic, Polay-Espinosa Micaela, Matloka Magdalena, Bazinet Audrey, De Dea Diniz Damily, Naouar Naïra, Rau Frédérique, Jollet Arnaud, Edom-Vovard Frédérique, Mamchaoui Kamel, Tarnopolsky Mark, Puymirat Jack, Battail Christophe, Boland Anne, Deleuze Jean-Francois, Mouly Vincent, Klein F Arnaud, Furling Denis
Myotonic dystrophy type 1 (DM1) and type 2 (DM2) are autosomal dominant neuromuscular diseases caused by microsatellite expansions and belong to the family of RNA dominant disorders. Availability of cellular models in which the DM mutation is expressed within its natural context is essential to facilitate efforts to identify new therapeutic compounds. Here we generated immortalized DM1 and DM2 human muscle cell lines that display nuclear RNA-aggregates of expanded repeats, a hallmark of myotonic dystrophy. Selected clones of DM1 and DM2 immortalized myoblasts behave as parental primary myoblasts with a reduced fusion capacity of immortalized DM1 myoblasts when compared to control and DM2 cells...
February 10, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28174362/most-frequent-oral-lesions-in-patients-with-type-2-diabetes-mellitus
#12
Micheline S Trentin, Georgia Verardi, Michele De C Ferreira, João P de Carli, Soluete O da Silva, Igor Fp Lima, Luiz R Paranhos
AIM: Type 2 diabetes mellitus (DM2) is a chronic disease caused by the underproduction of insulin in the organism and it is considered a risk factor to periodontal disease. MATERIALS AND METHODS: This study performed a cross-sectional research on the main oral changes in patients with DM2 and nondiabetics, in Passo Fundo, Rio Grande do Sul, Brazil. The sample included 116 patients examined at the Diabetes Outpatient Clinic of the School of Medicine of the University of Passo Fundo (UPF) and 134 nondiabetic patients examined at the Examinations, Triage, and Emergency Sector of the School of Dentistry of UPF...
February 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28150817/association-of-genomic-instability-with-hba1c-levels-and-medication-in-diabetic-patients
#13
Annemarie Grindel, Helmut Brath, Armen Nersesyan, Siegfried Knasmueller, Karl-Heinz Wagner
Diabetes Mellitus type 2 (DM2) is associated with increased cancer risk. Instability of the genetic material plays a key role in the aetiology of human cancer. This study aimed to analyse genomic instability with the micronucleus cytome assay in exfoliated buccal cells depending on glycated haemoglobin (HbA1c) levels and medication in 146 female DM2 patients. The occurrence of micronuclei was significantly increased in DM2 patients compared to healthy controls. Furthermore, it was doubled in DM2 patients with HbA1c > 7...
February 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28138861/zinc-s-role-in-the-glycemic-control-of-patients-with-type-2-diabetes-a-systematic-review
#14
REVIEW
Gabrielli Barbosa de Carvalho, Paula Nascimento Brandão-Lima, Carla Soraya Costa Maia, Kiriaque Barra Ferreira Barbosa, Liliane Viana Pires
Past research has shown the importance of zinc in several metabolic processes, such as the glucidic metabolism. The present systematic review aims to discuss zinc's participation in the glycemic control of type 2 diabetes mellitus (DM2) patients. In order to accomplish that, a systematic search was performed in the Pubmed database using the following indexed and theme-related descriptors: "zinc" AND "type 2 diabetes mellitus", AND MeSH terms related to glycemic control combined with the boolean operator OR...
January 30, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/28138246/association-of-peripheral-neuropathy-with-sleep-related-breathing-disorders-in-myotonic-dystrophies
#15
Marta Banach, Jakub Antczak, Rafał Rola
BACKGROUND: Myotonic dystrophy (DM) type 1 and type 2 are inherited diseases characterized by myotonia and myopathy. Additional symptoms include, among others, peripheral neuropathy and sleep-related breathing disorders (SRBDs). There is growing evidence for a complex association between DM1 and DM2, which was described in patients with diabetes mellitus and in the general population. In this study, we investigated whether there is an association between peripheral neuropathy and SRBDs also in the population of patients with DM...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28118051/the-relationship-between-brown-adipose-tissue-content-in-supraclavicular-fat-depots-and-insulin-sensitivity-in-patients-with-type-2-diabetes-mellitus-and-prediabetes
#16
Ekaterina Koksharova, Dmitry Ustyuzhanin, Yury Philippov, Alexander Mayorov, Marina Shestakova, Merab Shariya, Sergey Ternovoy, Ivan Dedov
BACKGROUND: The evaluation of brown adipose tissue (BAT) and its role in metabolism and obesity remains an important topic in the recent literature. This study evaluated the influence of the BAT triglyceride content measured by proton magnetic resonance (MR) spectroscopy in patients with type 2 diabetes mellitus (DM2) and prediabetes on insulin sensitivity. METHODS: A total of 25 patients with DM2 and prediabetes (45.9 ± 10.1 years old, body mass index [BMI] of 31...
February 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28106565/neuromyelitis-optica-in-a-patient-from-family-with-both-myotonic-dystrophy-type%C3%A2-1-and-2
#17
V Rakocevic-Stojanovic, S Peric, I Dujmovic, J Drulovic, J Pesovic, D Savic-Pavicevic
INTRODUCTION: The aim of this study was to present a family co-segregating myotonic dystrophy type 1 (DM1) and 2 (DM2), and one member affected with neuromyelitis optica (NMO). CASE REPORT: Index case underwent cataract surgery at age 39. Although she had no muscle symptoms, genetic testing revealed a DM2 mutation and a DM1 protomutation. The patient noticed difficulties in climbing stairs at age 47. Clinical examination showed mild muscle weakness, calf hypertrophy, mild myotonia and several multisystem signs...
2017: Journal of Neuromuscular Diseases
https://www.readbyqxmd.com/read/28102898/a-composite-autonomic-index-as-unitary-metric-for-heart-rate-variability-a-proof-of-concept
#18
Roberto Sala, Mara Malacarne, Nadia Solaro, Massimo Pagani, Daniela Lucini
BACKGROUND: This study addresses whether a unitary cardiac autonomic nervous system index (ANSI), obtained combining multiple metrics from heart rate variability (HRV) into a radar plot could provide an easy appreciation of autonomic performance in a clinical setting. MATERIALS AND METHODS: Data are standardized using percentile ranking of autonomic proxies from a relatively large reference population (n = 1593, age 39 ± 13 years). Autonomic indices are obtained from autoregressive spectral analysis of (ECG derived) HRV at rest and during standing up...
January 19, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28078562/myotonic-dystrophy-type-2-and-modifier-genes-an-update-on-clinical-and-pathomolecular-aspects
#19
REVIEW
Giovanni Meola, Rosanna Cardani
Myotonic dystrophy (DM) is the most common adult muscular dystrophy, characterized by autosomal dominant progressive myopathy, myotonia, and multiorgan involvement. To date, two distinct forms caused by similar mutations in two different genes have been identified: myotonic dystrophy type 1 (DM1) and myotonic dystrophy type 2 (DM2). Aberrant transcription and mRNA processing of multiple genes due to RNA-mediated toxic gain-of function has been suggested to cause the complex phenotype in DM1 and DM2. However, despite clinical and genetic similarities, DM1 and DM2 may be considered as distinct disorders...
January 11, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28074982/-healthcare-mistreatment-attributed-to-discrimination-among-mapuche-patients-and-discontinuation-of-diabetes-care
#20
Manuel S Ortiz, María José Baeza-Rivera, Natalia Salinas-Oñate, Patricia Flynn, Héctor Betancourt
BACKGROUND: The negative impact of perceived discrimination on health outcomes is well established. However, less attention has been directed towards understanding the effect of perceived discrimination on health behaviors relevant for the treatment of diabetes in ethnic minorities. AIM: To examine the effects of healthcare mistreatment attributed to discrimination on the continuity of Type 2 Diabetes (DM2) care among mapuche patients in a southern region of Chile...
October 2016: Revista Médica de Chile
keyword
keyword
59498
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"