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https://www.readbyqxmd.com/read/28632304/are-visceral-adiposity-index-and-lipid-accumulation-product-reliable-indices-for-metabolic-disturbances-in-patients-with-type-2-diabetes-mellitus
#1
Nebojsa Kavaric, Aleksandra Klisic, Ana Ninic
BACKGROUND: Visceral adiposity index (VAI) and Lipid accumulation product (LAP) are novel visceral adiposity indexes, proposed for the evaluation of cardiometabolic risk in adult population. Considering contradictory results obtained from many studies so far, we aimed to examine the potential benefit of applicability of VAI and LAP, over simple anthropometric indices and traditional lipid parameters in individuals with type 2 diabetes mellitus (DM2). METHODS: A total of 180 DM2 (of them 50% females) and 119 controls who volunteered to participate in this cross-sectional study were enrolled...
June 20, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28627186/%C3%A3-ndice-glic%C3%A3-mico-carga-glic%C3%A3-mica-e-insulina-posprandial-a-dos-f%C3%A3-rmulas-isogluc%C3%A3-dicas-con-distintos-edulcorantes-y-fibra-en-adultos-sanos-y-diab%C3%A3-ticos-tipo-2
#2
Lissé Angarita Dávila, José López Miranda, Daniel Aparicio Camargo, Karla Parra Zuleta, Maria Uzcátegui González, Virginia Céspedes Nava, Samuel Durán Agüero, Nadia Reyna Villasmil
Objetivo: el objetivo de este estudio fue comparar el índice glicémico (IG), la carga glicémica (CG) y la insulina posprandial de dos fórmulas isoglucídicas con distintos edulcorantes y fibra en adultos sanos y diabéticos tipo 2 (DM2).Metodología: en este estudio aleatorizado, cruzado y doble ciego, once sujetos sanos y seis diabéticos consumieron dos fórmulas en cuatro ocasiones (Glucerna SR® Laboratorios Abbott C.A [FG] y Enterex Diabetic®, Victus, C.A [FE], edulcoradas con fructosa y sucralosa respectivamente, con distintas fuentes de fibra), además de solución glucosada (SG) en una ocasión...
June 5, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28623239/-ccug-n-rna-toxicity-in-a-drosophila-model-for-myotonic-dystrophy-type-2-dm2-activates-apoptosis
#3
Vildan Betul Yenigun, Mario Sirito, Alla Amcheslavky, Tomek Czernuszewicz, Jordi Colonques-Bellmunt, Irma García-Alcover, Marzena Wojciechowska, Clare Bolduc, Zhihong Chen, Arturo López Castel, Ralf Krahe, Andreas Bergmann
The myotonic dystrophies are prototypic toxic RNA gain-of-function diseases. Myotonic dystrophy type 1 (DM1) and type 2 (DM2) are caused by different unstable, noncoding microsatellite repeat expansions -- (CTG)DM1 in DMPK and (CCTG)DM2 in CNBP Although transcription of mutant repeats into (CUG)DM1 or (CCUG)DM2 appears to be necessary and sufficient to cause disease, their pathomechanisms remain incompletely understood. To study the mechanisms of (CCUG)DM2 toxicity and develop a convenient model for drug screening, we generated a transgenic DM2 model in the fruit fly Drosophila melanogaster with (CCUG)n repeats of variable length (n=16 and 106)...
June 16, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28619294/impact-of-mulberry-leaf-extract-on-type-2-diabetes-mul-dm-a-randomized-placebo-controlled-pilot-study
#4
Daniel M Riche, Krista D Riche, Honey E East, Elizabeth K Barrett, Warren L May
AIMS: Mulberry leaves have been used anecdotally in Asia to treat many disease states, including glucose abnormalities. Animal and human studies illustrate potential benefit of mulberry leaf extract (MLE) in type 2 diabetes mellitus (DM2). The purpose of this study is to evaluate the glycemic and safety effects of MLE in patients with DM2. MATERIALS & METHODS: This randomized, double-blind, placebo-controlled pilot study evaluated MLE (1000mg standardized) versus matching placebo given three times daily with meals...
June 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28588248/expanded-ccug-repeat-rna-expression-in-drosophila-heart-and-muscle-trigger-myotonic-dystrophy-type-1-like-phenotypes-and-activate-autophagocytosis-genes
#5
Estefania Cerro-Herreros, Mouli Chakraborty, Manuel Pérez-Alonso, Rubén Artero, Beatriz Llamusí
Myotonic dystrophies (DM1-2) are neuromuscular genetic disorders caused by the pathological expansion of untranslated microsatellites. DM1 and DM2, are caused by expanded CTG repeats in the 3'UTR of the DMPK gene and CCTG repeats in the first intron of the CNBP gene, respectively. Mutant RNAs containing expanded repeats are retained in the cell nucleus, where they sequester nuclear factors and cause alterations in RNA metabolism. However, for unknown reasons, DM1 is more severe than DM2. To study the differences and similarities in the pathogenesis of DM1 and DM2, we generated model flies by expressing pure expanded CUG ([250]×) or CCUG ([1100]×) repeats, respectively, and compared them with control flies expressing either 20 repeat units or GFP...
June 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28586059/identification-of-critical-genes-in-nucleus-pulposus-cells-isolated-from-degenerated-intervertebral-discs-using-bioinformatics-analysis
#6
Zhuangchen Zhu, Guang Chen, Wei Jiao, Defeng Wang, Yan Cao, Qingfu Zhang, Junqin Wang
Intervertebral disc (IVD) degeneration is a pathological process, which may lead to lower back pain. The present study aimed to investigate the pathogenesis of IVD degeneration. GSE42611 was downloaded from Gene Expression Omnibus, including 4 nucleus pulposus samples isolated from degenerated IVDs and 4 nucleus pulposus samples separated from normal IVDs. The differentially expressed genes (DEGs) between the degenerated and normal samples were screened using the limma package in R. Functional and pathway enrichment analyses were conducted separately for the upregulated and downregulated genes, using Database for Annotation, Visualization and Integrated Discovery software...
July 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28583071/volume-time-curve-of-cardiac-magnetic-resonance-assessed-left-ventricular-dysfunction-in-coronary-artery-disease-patients-with-type-2-diabetes-mellitus
#7
Hua-Yan Xu, Zhi-Gang Yang, Ying-Kun Guo, Ke Shi, Xi Liu, Qin Zhang, Li Jiang, Lin-Jun Xie
BACKGROUND: Type 2 diabetes mellitus (DM2) may induce epicardial coronary artery diseases and left ventricular myocardial damaging as well. Left ventricular dysfunction was found in DM2. In this research, we compared the left ventricular dysfunction of coronary artery disease (CAD) patients with and without type 2 diabetes mellitus as well as normal controls using the volume-time curve of cardiac magnetic resonance (CMR). METHODS: Sixty-one CAD patients (28 with DM2 and 33 without DM2) and 18 normal individuals were enrolled in this study...
June 5, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28566162/brain-positron-emission-tomography-in-patients-with-myotonic-dystrophy-type-1-and-type-2
#8
Stojan Peric, Leposava Brajkovic, Bozidar Belanovic, Vera Ilic, Biljana Salak-Djokic, Ivana Basta, Vidosava Rakocevic Stojanovic
AIM: To determine regions of reduced brain metabolism in patients with myotonic dystrophy type 1 (DM1) and type 2 (DM2) using 18F-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET), and to analyse their potential association with cognitive deficit. METHOD: Study included 29 patients (16 DM1 and 13 DM2). FDG-PET and detailed neuropsychological testing were performed in both groups. RESULTS: The most common cognitive findings were executive, visuospatial, and naming dysfunction in DM1, and executive and naming dysfunction in DM2...
July 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28550479/biomolecular-diagnosis-of-myotonic-dystrophy-type-2-a-challenging-approach
#9
REVIEW
Giovanni Meola, Fiammetta Biasini, Rea Valaperta, Elena Costa, Rosanna Cardani
Myotonic dystrophy type 1 (DM1) and type 2 (DM2) are the most common adult form of muscular dystrophy, characterized by autosomal dominant progressive myopathy, myotonia, and multiorgan involvement. The onset and symptoms of the myotonic dystrophies are diverse, complicating their diagnoses and limiting a comprehensive approach to their clinical care. Diagnostic delay in DM2 is due not only to the heterogeneous phenotype and the aspecific onset but also to the unfamiliarity with the disorder by most clinicians...
May 26, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28548885/metformin-inhibits-p-gingivalis-lipopolysaccharide-lps-influenced-inflammatory-response-in-human-gingival-fibroblasts-via-regulating-activating-transcription-factor-3-atf3-expression
#10
Wenyan Kang, Ting Wang, Zhekai Hu, Feng Liu, Yundong Sun, Shaohua Ge
BACKGROUND: Chronic periodontitis is one of the most prevalent oral diseases, which is associated with Porphyromonas gingivalis (P. gingivalis) Lipopolysaccharide (LPS) infection, and has profound effects on type 2 diabetes mellitus (DM2). Metformin, a well-known antidiabetic agent, has been reported to exert anti-inflammatory effects on various cells. This study aimed to investigate the role of metformin on LPS-influenced inflammatory response in human gingival fibroblasts (HGFs). METHODS: Dose-dependent additive effects of metformin on LPS-influenced HGFs were detected...
May 26, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28544772/ganglioside-gm3-content-in-skeletal-muscles-is-increased-in-type-2-but-decreased-in-type-1-diabetes-rat-models-implications-of-glycosphingolipid-metabolism-in-pathophysiology-of-diabetes
#11
Josko Bozic, Anita Markotic, Vedrana Cikes-Culic, Anela Novak, Josip Andelo Borovac, Hrvoje Vucemilovic, Gorana Trgo, Tina Ticinovic Kurir
BACKGROUND: Ganglioside GM3 is an abundant constituent of the plasma membrane where its accumulation attenuates insulin receptor signaling. Considering the role of skeletal muscles for insulin-stimulated glucose uptake, the aim of this study was to determine the expression of GM3 and its precursors in skeletal muscle of diabetes mellitus type 1 (DM1) and type 2 (DM2) rat models. METHODS: Diabetes was induced by streptozotocin (55 mg/kg for DM1 and 35 mg/kg for DM2) injection to male Sprague-Dawley rats which were fed with normal pellet diet (DM1 type) or high-fat diet (DM2 type)...
May 22, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28535564/the-different-dynamic-changes-of-nerve-growth-factor-in-the-dorsal-horn-and-dorsal-root-ganglion-leads-to-hyperalgesia-and-allodynia-in-diabetic-neuropathic-pain
#12
Zhifeng Gao, Yi Feng, Hui Ju
BACKGROUND: Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes and more than half of the patients with DPN have self-reported symptoms referring to painful diabetic neuropathy (PDN). Nerve growth factor (NGF) is a key factor for the nervous system, but the role of it in the neuropathic pain of diabetic patients is unclear. OBJECTIVE: This study aimed to investigate the relationship between the dynamic expression of NGF in dorsal horn and dorsal root ganglion (DRG) of diabetic rats and hyperalgesia and allodynia in diabetic neuropathic pain...
May 2017: Pain Physician
https://www.readbyqxmd.com/read/28514910/value-based-healthcare-measurement-as-a-context-for-organizational-learning
#13
Patrik Nordin, Anna-Aurora Kork, Inka Koskela
Purpose The purpose of this paper is to shed light on the potential of organizational learning for developing effectiveness of care. Value-based healthcare measurement recognizes patient value as a driver for improving health outcomes at the societal and individual levels. By using the action learning method, this paper examines the phases of organizational learning in a private healthcare organization that has developed a novel Big Data screening tool for the treatment of patients with type 2 diabetes mellitus (DM2)...
May 2, 2017: Leadership in Health Services
https://www.readbyqxmd.com/read/28495321/increased-salivary-oxidative-stress-parameters-in-patients-with-type-2-diabetes-relation-with-periodontal-disease
#14
Carlos Arana, Ana María Moreno-Fernández, Gerardo Gómez-Moreno, Cristóbal Morales-Portillo, Isabel Serrano-Olmedo, M Carmen de la Cuesta Mayor, Tomás Martín Hernández
OBJECTIVE: The aim of this study was to determine whether there are differences in salivary oxidative stress between patients with diabetes mellitus type 2 (DM2) and healthy non-diabetic patients, and whether this oxidative stress is associated with the presence of periodontal disease in diabetic patients. MATERIAL AND METHODS: This observational study included 70 patients divided into three groups according to metabolic control levels: 19 non-diabetic patients (control group); 24 patients with good metabolic control (HbA1c<7%), and 27 patients DM2 with poor metabolic control (HbA1c>7%)...
May 2017: Endocrinología, diabetes y nutrición
https://www.readbyqxmd.com/read/28490181/annals-express-designing-and-evaluating-autoverification-rules-for-thyroid-function-profiles-and-sex-hormone-tests
#15
Jiancheng Li, Bizhen Cheng, Huizhen Ouyang, Tongtong Xiao, Jing Hu, Yingmu Cai
PURPOSE: Following the analytical phase, the current practice of many hospital laboratories involves the manual verification of all test results followed by the production of the report. However, manual verification is a time-consuming and tedious process. In this paper, we provide a detailed description of how to design autoverification rules for thyroid function test profiles and sex hormones. MaterialsandMethods: We used DM2 (Data manager 2) to construct the algorithm and build the database for autoverification of thyroid function test profiles and sex hormones, with reference to Boolean logic, Auto-10A and CLSI'88...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28435814/gender-dependent-differences-in-the-relationship-between-diabetes-mellitus-and-ambient-air-pollution-among-adults-in-south-korean-cities
#16
Dongwook Sohn, Hyunjin Oh
BACKGROUND: Air pollution has been a serious public health threat worldwide. It has been linked to pulmonary and cardiovascular diseases but is also believed to contribute to air-pollution-mediated cardiometabolic disease such as diabetes. We investigated the relationship between type 2 diabetes mellitus (DM2) and air pollution in densely developed urban settings in South Korea, using national epidemiologic data. METHODS: The analysis focused on examining gender-related differences in the relationship between DM 2 and air pollutants, specifically particulate matter ≤ 10μm (PM10) and sulfur dioxide (SO2)...
March 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28416121/silent-coronary-heart-disease-in-patients-with-type-2-diabetes-application-of-a-screening-approach-in-a-follow-up-study
#17
Saula Vigili de Kreutzenberg, Anna Solini, Edoardo Vitolo, Alessandra Boi, Simonetta Bacci, Sara Cocozza, Rossella Nappo, Angela Rivellese, Angelo Avogaro, Marco Giorgio Baroni
AIMS: The cost-effectiveness of screening for silent coronary heart disease (CHD) in type 2 diabetes (DM2) is still debated. METHODS: We applied a diagnostic algorithm for silent CHD detection, in a cohort of 102 asymptomatic DM2 subjects (57±7years), attending 5 Italian outpatient clinics, to verify its predictive value. The risk of silent CHD was calculated considering classical risk factors, and presence of microangiopathy/macroangiopathy. Patients were divided in 3 groups, i...
June 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28416116/activation-of-a-plant-nlr-complex-through-heteromeric-association-with-an-autoimmune-risk-variant-of-another-nlr
#18
Diep T N Tran, Eui-Hwan Chung, Anette Habring-Müller, Monika Demar, Rebecca Schwab, Jeffery L Dangl, Detlef Weigel, Eunyoung Chae
When independently evolved immune receptor variants meet in hybrid plants, they can activate immune signaling in the absence of non-self recognition. Such autoimmune risk alleles have recurrently evolved at the DANGEROUS MIX2 (DM2) nucleotide-binding domain and leucine-rich repeat (NLR)-encoding locus in A. thaliana. One of these activates signaling in the presence of a particular variant encoded at another NLR locus, DM1. We show that the risk variants of DM1 and DM2d NLRs signal through the same pathway that is activated when plant NLRs recognize non-self elicitors...
April 24, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28410617/treatment-with-high-dose-n-3-pufas-has-no-effect-on-platelet-function-coagulation-metabolic-status-or-inflammation-in-patients-with-atherosclerosis-and-type-2-diabetes
#19
Malgorzata Poreba, Magdalena Mostowik, Aleksander Siniarski, Renata Golebiowska-Wiatrak, Krzysztof Piotr Malinowski, Maciej Haberka, Ewa Konduracka, Jadwiga Nessler, Anetta Undas, Grzegorz Gajos
BACKGROUND: Despite numerous studies on cardioprotective effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs), there is limited evidence for n-3 PUFA-mediated effects, especially at its higher dose, on cardiovascular risk in patients with type 2 diabetes (DM2) and established atherosclerosis. PURPOSE: To investigate the effect of daily treatment with a higher dose (2 g) of n-3 PUFAs on platelet function, coagulation parameters, fibrin clot properties, markers of systemic inflammation and metabolic status, in patients with atherosclerotic vascular disease and DM2 who receive optimal medical therapy...
April 14, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28379159/delphinidin-reduces-glucose-uptake-in-mice-jejunal-tissue-and-human-intestinal-cells-lines-through-ffa1-gpr40
#20
Jorge Hidalgo, Stefanie Teuber, Francisco J Morera, Camila Ojeda, Carlos A Flores, María A Hidalgo, Lucía Núñez, Carlos Villalobos, Rafael A Burgos
Anthocyanins are pigments with antihyperglycemic properties, and they are potential candidates for developing functional foods for the therapy or prevention of Diabetes mellitus type 2 (DM2). The mechanism of these beneficial effects of anthocyanins are, however, hard to explain, given their very low bioavailability due to poor intestinal absorption. We propose that free fatty acid receptor 1 (FFA1, also named GPR40), is involved in an inhibitory effect of the anthocyanidin delphinidin over intestinal glucose absorption...
April 5, 2017: International Journal of Molecular Sciences
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