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https://www.readbyqxmd.com/read/29927982/influenza-d-virus-m2-protein-exhibits-ion-channel-activity-in-xenopus-laevis-oocytes
#1
Evan Kesinger, Jianing Liu, Aaron Jensen, Catherine P Chia, Andrew Demers, Hideaki Moriyama
BACKGROUND: A new type of influenza virus, known as type D, has recently been identified in cattle and pigs. Influenza D virus infection in cattle is typically asymptomatic; however, its infection in swine can result in clinical disease. Swine can also be infected with all other types of influenza viruses, namely A, B, and C. Consequently, swine can serve as a "mixing vessel" for highly pathogenic influenza viruses, including those with zoonotic potential. Currently, the only antiviral drug available targets influenza M2 protein ion channel is not completely effective...
2018: PloS One
https://www.readbyqxmd.com/read/29915971/metabolic-surgery-for-the-treatment-of-diabetes-mellitus-positioning-of-leading-medical-associations-in-mexico
#2
Miguel F Herrera, Eduardo García-García, Juan F Arellano-Ramos, Miguel Agustín Madero, Jorge Antonio Aldrete-Velasco, Juan Antonio López Corvalá
INTRODUCTION: Metabolic surgery (MS) can be a useful therapeutic strategy in patients with type 2 diabetes (DM2) and obesity. OBJECTIVE: To define the place of MS within DM2 treatment in Mexico. METHODS: A committee of experts consisting of internists and surgeons representing the leading Mexican associations involved in the field was created. Each one responded to a specific question regarding mechanisms involved in controlling DM2, surgical procedures, and the indications and contraindications for MS...
June 18, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29897477/predictive-risk-model-for-the-diagnosis-of-diabetes-mellitus-type-2-in-a-follow-up-study-15-years-on-prodi2-study
#3
Luisa M Moreno, Jesús Vergara, Raquel Alarcón
Background: The prevalence and mortality related to diabetes mellitus type 2 (DM2) have increased consistently for decades. Identifying adults at high risk of diabetes incidence is important for the execution of intervention. Methods: The participants in the PRODI2 study (n=273), who come from the southeast of Spain and did not have diabetes at the start of the study, were followed for 15 years (1999-2014), and their risk parameters were measured, from which a predictive model was obtained which indicates the level of influence of each factor in the development of DM2...
June 11, 2018: European Journal of Public Health
https://www.readbyqxmd.com/read/29892259/abnormalities-in-skeletal-muscle-myogenesis-growth-and-regeneration-in-myotonic-dystrophy
#4
REVIEW
Laurène M André, C Rosanne M Ausems, Derick G Wansink, Bé Wieringa
Myotonic dystrophy type 1 (DM1) and 2 (DM2) are autosomal dominant degenerative neuromuscular disorders characterized by progressive skeletal muscle weakness, atrophy, and myotonia with progeroid features. Although both DM1 and DM2 are characterized by skeletal muscle dysfunction and also share other clinical features, the diseases differ in the muscle groups that are affected. In DM1, distal muscles are mainly affected, whereas in DM2 problems are mostly found in proximal muscles. In addition, manifestation in DM1 is generally more severe, with possible congenital or childhood-onset of disease and prominent CNS involvement...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29891175/impact-of-smoking-cessation-on-estimated-cardiovascular-risk-in-spanish-type-2-diabetes-mellitus-patients-the-diabetes-study
#5
M Luque-Ramírez, V Sanz de Burgoa
AIMS: To assess the cardiovascular risk according to the UKPDS risk engine; Framingham function and score comparing clinical characteristics of diabetes mellitus type 2 (DM2) patients according to their habits status. PATIENTS AND METHODS: A descriptive analysis was performed. A total of 890 Spanish patients with DM2 (444 smokers and 446 former-smokers) were included in a cross-sectional, observational, epidemiological multicenter nationwide study. Coronary heart disease risk at 10 years was calculated using the UKPDS risk score in both patient subgroups...
June 8, 2018: Revista Clínica Española
https://www.readbyqxmd.com/read/29887834/diabetes-mellitus-and-infertility-different-pathophysiological-effects-in-type-1-and-type-2-on-sperm-function
#6
Rosita A Condorelli, Sandro La Vignera, Laura M Mongioì, Angela Alamo, Aldo E Calogero
Although the prevalence of sub-infertility in diabetic patients in childbearing age is known, the mechanisms by which diabetes mellitus (DM) causes male infertility are not completely explained. This detrimental effect is achieved with a variety of mechanisms that include pre-testicular, testicular, and post-testicular pathogenetic moments and can be different in type 1 diabetes mellitus (DM1) and type 2 diabetes mellitus (DM2) patients because of type of diabetes, duration of disease, and glycemic metabolic compensation...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29885466/comparative-analysis-on-liver-transcriptome-profiles-of-different-methods-to-establish-type-2-diabetes-mellitus-models-in-guangxi-bama-mini-pig
#7
Yanjun Wu, Li Zhang, Jing Liang, Qinyang Jiang, Yafen Guo, Ganqiu Lan
AIMS/INTRODUCTION: Streptozotocin (STZ) is a permanent diabetogenic compound and often used in animal diabetes modeling. The aim of this study is to compare the liver transcriptome of type 2 diabetes models (T2DM) in Guangxi Bama Mini-pig (GBM pig) induced by STZ or Non-STZ. RESEARCH DESIGN AND METHODS: 22 female GBM pigs were divided into 4 groups. Ctr group (4 pigs): standard diets; DM1_HH group (10 pigs): high fat and high carbohydrate diets; DM2_HS group (4 pigs): high fat and high carbohydrate diets + STZ; DM3_SH group (4 pigs): STZ + high fat and high carbohydrate diets...
June 6, 2018: Gene
https://www.readbyqxmd.com/read/29880430/withdrawn-evidence-for-a-relatively-high-proportion-of-dm2-mutations-in-a-large-group-of-polish-patients
#8
Anna Sulek, Anna Lusakowska, Wioletta Krysa, Marta Rajkiewicz, Anna Kaminska, Monika Nojszewska, Anna Kostera-Pruszczyk, Elzbieta Zdzienicka, Jolanta Kubalska, Maria Rakowicz, Walentyna Szirkowiec, Hubert Kwiecinski, Jacek Zaremba
The Publisher regrets that this article is an accidental duplication of an article that has already been published, 10.1016/j.pjnns.2018.02.008. The duplicate article has therefore been withdrawn. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal.
May 17, 2018: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29859478/association-of-sleep-disordered-breathing-with-severe-chronic-vascular-disease-in-patients-with-type-2-diabetes
#9
Stefan Stadler, Shabnam Jalili, Andreas Schreib, Bettina Jung, Florian Zeman, Carsten A Böger, Iris M Heid, Michael Arzt
BACKGROUND: Severe chronic vascular disease (CVD) is a major cause of co-morbidity and mortality in patients with type 2 diabetes (DM2). Sleep-disordered breathing (SDB) has been linked to CVD in the general population due to enhanced sympathetic activation, oxidative stress, endothelial dysfunction, and hypertension; however data for DM2 patients is scarce. Therefore, the aim of the present analysis to assess whether SDB is associated with CVD in patients with DM2, independent of other known associated factors...
May 14, 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29847240/characterization-of-silver-release-from-nanoparticle-treated-baby-products
#10
Ru Ding, Pingjian Yang, Yuan Yang, Zhaoguang Yang, Li Luo, Haipu Li, Qiang Wang
We tested six kinds of commercially available baby products containing nano-silver and divided them into two categories: baby food containers and baby oral care products, according to usage. We measured the total mass of silver, particle size, particle number concentration and the mobility under different simulated conditions. The total mass of silver in baby products and migration solutions was quantified by ICP-MS analysis, and the size of the migrated particles was investigated by single particle ICP-MS and TEM-EDS...
May 30, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29846960/evaluation-of-defb1-polymorphisms-in-individuals-with-chronic-periodontitis-and-diabetes-mellitus-type-2-in-a-population-of-northeastern-brazil
#11
Rayanne Soraia Aguiar de Melo Dias, Roberto Carlos Mourão Pinho, Felipe Rodrigues de Almeida, Francisco Alfredo Farias Bandeira, Ronaldo Celerino da Silva, Sergio Crovella, Bruna de Carvalho Farias Vajgel, Renata Cimões
AIMS: The role of genetic variations in genes related to innate response, as β-defensin-1 (DEFB1), in the context of chronic periodontitis (CP) and diabetes mellitus type 2 (DM2), is still not clear. The present study evaluates the distribution of DEFB1 single nucleotide polymorphisms (SNPs) 5'-untranslated (5'UTR) region and its relation with the CP in DM2 individuals in northeastern Brazilians. METHODS: Two hundred and eighty individuals participated in the study, being 116 DM2+CP, 95 CP, and 69 healthy individuals...
May 30, 2018: Special Care in Dentistry
https://www.readbyqxmd.com/read/29804263/reabsorption-in-the-proximal-tubuli-ultrastructural-evidence-for-a-novel-aspect-of-renal-vegf-trafficking
#12
Marija Vitlov Uljević, Ivana Bočina, Ivana Restović, Nenad Kunac, Tomislav Mašek, Genia Kretzschmar, Maximilian Grobe, Mia Šarić, Katarina Vukojević, Mirna Saraga-Babić, Natalija Filipović
Many clinical and experimental studies have revealed VEGF as an important factor in the pathophysiology of renal damage during diabetes mellitus (DM). Anti-VEGF therapy is in clinical use for treatment of DM and other diabetes-related (and unrelated) diseases. Nevertheless, little is known about the metabolism of VEGF in the kidneys. In order to determine the ultrastructural localization of VEGF in the kidney, we study the distribution of VEGF in the kidney of rats by using immunogold immunohistochemistry. Our light-microscopic data showed remarkable re-distribution of VEGF in proximal tubular cells (PTCs) during prolonged hyperglycemia, a DM type 2 model (DM2), which was confirmed by transmission electron microscopy (TEM) findings...
May 26, 2018: Cell and Tissue Research
https://www.readbyqxmd.com/read/29789616/rbfox1-mbnl1-competition-for-ccug-rna-repeats-binding-contributes-to-myotonic-dystrophy-type-1-type-2-differences
#13
Chantal Sellier, Estefanía Cerro-Herreros, Markus Blatter, Fernande Freyermuth, Angeline Gaucherot, Frank Ruffenach, Partha Sarkar, Jack Puymirat, Bjarne Udd, John W Day, Giovanni Meola, Guillaume Bassez, Harutoshi Fujimura, Masanori P Takahashi, Benedikt Schoser, Denis Furling, Ruben Artero, Frédéric H T Allain, Beatriz Llamusi, Nicolas Charlet-Berguerand
Myotonic dystrophy type 1 and type 2 (DM1, DM2) are caused by expansions of CTG and CCTG repeats, respectively. RNAs containing expanded CUG or CCUG repeats interfere with the metabolism of other RNAs through titration of the Muscleblind-like (MBNL) RNA binding proteins. DM2 follows a more favorable clinical course than DM1, suggesting that specific modifiers may modulate DM severity. Here, we report that the rbFOX1 RNA binding protein binds to expanded CCUG RNA repeats, but not to expanded CUG RNA repeats...
May 22, 2018: Nature Communications
https://www.readbyqxmd.com/read/29770119/core-clinical-phenotypes-in-myotonic-dystrophies
#14
REVIEW
Stephan Wenninger, Federica Montagnese, Benedikt Schoser
Myotonic dystrophy type 1 (DM1) and type 2 (DM2) represent the most frequent multisystemic muscular dystrophies in adulthood. They are progressive, autosomal dominant diseases caused by an abnormal expansion of an unstable nucleotide repeat located in the non-coding region of their respective genes DMPK for DM1 and CNBP in DM2. Clinically, these multisystemic disorders are characterized by a high variability of muscular and extramuscular symptoms, often causing a delay in diagnosis. For both subtypes, many symptoms overlap, but some differences allow their clinical distinction...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29764429/health-and-quality-of-life-outcomes-impairment-of-quality-of-life-in-type-2-diabetes-mellitus-a-cross-sectional-study
#15
Jessie N Zurita-Cruz, Leticia Manuel-Apolinar, María Luisa Arellano-Flores, Alejandro Gutierrez-Gonzalez, Alma Gloria Najera-Ahumada, Nelly Cisneros-González
BACKGROUND: Type 2 diabetes mellitus (DM2) is a chronic disease, and for treatment to succeed, it is necessary to harmonize the mental health of the patient with the environment, which impacts quality of life and adherence to medical regimens. The objetive of this study is describe the quality of life of patients with DM2 and the factors relates to its modification. METHODS: This investigation was a cross-sectional study. Patients over 18 years of age with DM2 were selected...
May 15, 2018: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29756129/deep-multi-task-multi-channel-learning-for-joint-classification-and-regression-of-brain-status
#16
Mingxia Liu, Jun Zhang, Ehsan Adeli, Dinggang Shen
Jointly identifying brain diseases and predicting clinical scores have attracted increasing attention in the domain of computer-aided diagnosis using magnetic resonance imaging (MRI) data, since these two tasks are highly correlated. Although several joint learning models have been developed, most existing methods focus on using human-engineered features extracted from MRI data. Due to the possible heterogeneous property between human-engineered features and subsequent classification/regression models, those methods may lead to sub-optimal learning performance...
September 2017: Medical Image Computing and Computer-assisted Intervention: MICCAI ..
https://www.readbyqxmd.com/read/29748149/infant-juvenile-type-2-diabetes
#17
M L Calero Bernal, J M Varela Aguilar
In recent years, we have witnessed an increase in the number of cases of type 2 diabetes mellitus (DM2) in children and adolescents, which has paralleled the increase in the worldwide prevalence of obesity. Although screening the general population does not appear to be cost-effective, special attention should be paid to children with excess weight, obesity or other factors that predispose them to a state of insulin resistance. When faced with the diagnosis of childhood DM2, the presence of comorbidities (such as hypertension, dyslipidemia and microalbuminuria) should be assessed, and appropriate treatment and follow-up should be administered to prevent the onset of complications, given that the DM2 in this population group will last longer than that started in adulthood...
May 7, 2018: Revista Clínica Española
https://www.readbyqxmd.com/read/29735719/reduction-of-cellular-nucleic-acid-binding-protein-encoded-by-a-myotonic-dystrophy-type-2-gene-causes-muscle-atrophy
#18
Christina Wei, Lauren Stock, Christiane Schneider-Gold, Claudia Sommer, Nikolai A Timchenko, Lubov Timchenko
Myotonic Dystrophy type 2 (DM2) is a neuromuscular disease caused by an expansion of intronic CCTG repeats in the CNBP gene which encodes a protein regulating translation and transcription. To better understand the role of CNBP in DM2 pathology, we examined skeletal muscle in a new model of Cnbp knock out (KO) mice. This study showed that a loss of Cnbp disturbs myofibrillar sarcomeric organization at birth. Surviving homozygous Cnbp KO mice develop muscle atrophy at young age. Skeletal muscle phenotype in heterozygous Cnbp KO mice was milder, but they develop severe muscle wasting at advanced age...
May 7, 2018: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/29731703/metabolic-syndrome-and-neuroprotection
#19
REVIEW
Melisa Etchegoyen, Mariana H Nobile, Francisco Baez, Barbara Posesorski, Julian González, Néstor Lago, José Milei, Matilde Otero-Losada
Introduction: Over the years the prevalence of metabolic syndrome (MetS) has drastically increased in developing countries as a major byproduct of industrialization. Many factors, such as the consumption of high-calorie diets and a sedentary lifestyle, bolster the spread of this disorder. Undoubtedly, the massive and still increasing incidence of MetS places this epidemic as an important public health issue. Hereon we revisit another outlook of MetS beyond its classical association with cardiovascular disease (CVD) and Diabetes Mellitus Type 2 (DM2), for MetS also poses a risk factor for the nervous tissue and threatens neuronal function...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29726577/insulin-degrading-enzyme-is-up-regulated-in-pancreatic-_cells-by-insulin-treatment
#20
Cristina M Fernández-Díaz, Luis Escobar-Curbelo, J F López-Acosta, Carmen D Lobatón, Alfredo Moreno, Julián Sanz-Ortega, Germán Perdomo, Irene Cózar-Castellano
Insulin Degrading Enzyme (IDE) is an endopeptidase that degrades insulin and glucagon. Ide gene has been associated with type-2 diabetes mellitus (DM2). However, the physiological role(s) of IDE in glucose homeostasis and its potential therapeutic benefit remain not completely known. To contribute in the understanding of IDE's role in glucose metabolism, we analyzed IDE protein level in pancreatic islets from two hyperinsulinemic mouse models, db/db and high-fat diet (HFD) mice, as well as in human islets from DM2 patients treated with oral hypoglycemic agents (OHAs) or insulin...
May 4, 2018: Histology and Histopathology
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