keyword
MENU ▼
Read by QxMD icon Read
search

DM2

keyword
https://www.readbyqxmd.com/read/28106565/neuromyelitis-optica-in-a-patient-from-family-with-both-myotonic-dystrophy-type%C3%A2-1-and-2
#1
V Rakocevic-Stojanovic, S Peric, I Dujmovic, J Drulovic, J Pesovic, D Savic-Pavicevic
INTRODUCTION: The aim of this study was to present a family co-segregating myotonic dystrophy type 1 (DM1) and 2 (DM2), and one member affected with neuromyelitis optica (NMO). CASE REPORT: Index case underwent cataract surgery at age 39. Although she had no muscle symptoms, genetic testing revealed a DM2 mutation and a DM1 protomutation. The patient noticed difficulties in climbing stairs at age 47. Clinical examination showed mild muscle weakness, calf hypertrophy, mild myotonia and several multisystem signs...
January 20, 2017: Journal of Neuromuscular Diseases
https://www.readbyqxmd.com/read/28102898/a-composite-autonomic-index-as-unitary-metric-for-heart-rate-variability-a-proof-of-concept
#2
Roberto Sala, Mara Malacarne, Nadia Solaro, Massimo Pagani, Daniela Lucini
BACKGROUND: This study addresses whether a unitary cardiac autonomic nervous system index (ANSI), obtained combining multiple metrics from Heart Rate Variability (HRV) into a radar plot could provide an easy appreciation of autonomic performance in a clinical setting. MATERIALS AND METHODS: Data are standardized using percentile ranking of autonomic proxies from a relatively large reference population (n= 1593, age 39±13 years). Autonomic indices are obtained from autoregressive spectral analysis of (ECG derived) HRV at rest and during standing up...
January 19, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28078562/myotonic-dystrophy-type-2-and-modifier-genes-an-update-on-clinical-and-pathomolecular-aspects
#3
REVIEW
Giovanni Meola, Rosanna Cardani
Myotonic dystrophy (DM) is the most common adult muscular dystrophy, characterized by autosomal dominant progressive myopathy, myotonia, and multiorgan involvement. To date, two distinct forms caused by similar mutations in two different genes have been identified: myotonic dystrophy type 1 (DM1) and myotonic dystrophy type 2 (DM2). Aberrant transcription and mRNA processing of multiple genes due to RNA-mediated toxic gain-of function has been suggested to cause the complex phenotype in DM1 and DM2. However, despite clinical and genetic similarities, DM1 and DM2 may be considered as distinct disorders...
January 11, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28074982/-healthcare-mistreatment-attributed-to-discrimination-among-mapuche-patients-and-discontinuation-of-diabetes-care
#4
Manuel S Ortiz, María José Baeza-Rivera, Natalia Salinas-Oñate, Patricia Flynn, Héctor Betancourt
BACKGROUND: The negative impact of perceived discrimination on health outcomes is well established. However, less attention has been directed towards understanding the effect of perceived discrimination on health behaviors relevant for the treatment of diabetes in ethnic minorities. AIM: To examine the effects of healthcare mistreatment attributed to discrimination on the continuity of Type 2 Diabetes (DM2) care among mapuche patients in a southern region of Chile...
October 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/28074978/-effect-of-meal-frequency-and-carbohydrate-intake-on-the-metabolic-control-of-patients-with-type-2-diabetes-mellitus
#5
Tamara Leiva, Karen Basfi-Fer, Pamela Rojas, Fernando Carrasco, Manuel Ruz O
BACKGROUND: Increasing meal frequency is commonly used in the clinical practice as part of the nutritional treatment of patients with type 2 Diabetes Mellitus (DM2), although its effect on metabolic control parameters is controversial. AIM: To evaluate the association of energy intake, meal frequency, and amount of carbohydrates with fasting plasma glucose and glycosylated hemoglobin in a group of patients with DM2 without insulin therapy. MATERIAL AND METHODS: Dietary intake was evaluated in 60 subjects with DM2 through three-day food records...
October 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/28065683/cutaneous-features-of-myotonic-dystrophy-types-1-and-2-implication-of-premature-aging-and-vitamin-d-homeostasis
#6
Elena Campione, Annalisa Botta, Monia Di Prete, Emanuele Rastelli, Manuela Gibellini, Antonio Petrucci, Sergio Bernardini, Giuseppe Novelli, Luca Bianchi, Augusto Orlandi, Roberto Massa, Chiara Terracciano
Skin changes have been described in myotonic dystrophy type 1 (DM1). However, whether and in which way skin is a target of specific disease alterations in DM1 and DM2 has not been yet clarified. This study aims to explore cutaneous features of DM1 and DM2 patients. Skin examination was performed in 60 DM1, 15 DM2, and 103 control, unselected patients by means of dermoscopy. It revealed quantitative and qualitative abnormalities of nevi and typical signs of premature aging in both DM1 and DM2 patients, with a significantly higher frequency of dysplastic nevi, alopecia, xerosis and seborrheic dermatitis...
November 16, 2016: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/28062870/-metabolic-parameters-in-patients-with-steatosis-non-alcoholic-liver-and-controlled-diabetes-type-2-versus-uncontrolled-diabetes-type-2
#7
Gonzalo Miranda Manrique
: Non-alcoholic fatty liver (NASH) is widely distributed around the world and is more common in subjects with dyslipidemia, metabolic syndrome obese and DM2 (34-74%). However, the prevalence of cirrhosis by NASH in general population is unknown which is still subject of research. OBJECTIVE: To determine if there are significant differences between metabolic parameters of non-alcoholic fatty liver in controlled versus uncontrolled diabetes type 2 of recent diagnosis...
October 2016: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/28060977/-validation-of-the-borg-scale-in-participants-with-type-2-diabetes-mellitus
#8
Walter Rosales, Cristian Cofré, Cicchitti Alejandra, Celina Bertona, Alejandro Vizcaya, Joaquín González, Jorge Bajuk, Martín Rodríguez
BACKGROUND: Borg Rating of Perceived Exertion Scale (RPE) is a psychophysiological measurements that translates physical stimuli to a psychological construct, which is perceived exertion. Its use is simple and it represents the effort perception. Each number of the scale is associated with a heart rate or percentage of maximal oxygen consumption (VO2max), which estimates the intensity of exercise. AIM: To validate RPE scale in patients with type 2 diabetes mellitus (DM2)...
September 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/28060975/-prevalence-of-cardiovascular-risk-factors-in-a-rural-aymara-population-from-northern-chile
#9
Pablo Vargas M, Stephanie Saavedra P, María Virginia Araya A, Khanty Loyola A, Patricio Huerta G, Mariana Silva A, Scarlett Araya C, Willybaldo Saavedra A, Pilar Portales P, Willybaldo Saavedra P
BACKGROUND: Some rural non-Caucasian ethnic groups have genetic protective factors for the development of chronic non-communicable diseases. Studies performed in Mapuche and Aymara ethnic groups in Chile, found significantly lower prevalence rates. Aymaras are the second most common ethnic population in Chile. AIM: To determine the prevalence of cardiovascular risk factors in a native Aymara ethnic population. MATERIAL AND METHODS: We studied 276 native Aymara people with a median age of 53 years (63% women), registered in the rural clinics of Camiña and Putre...
September 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/28054923/descriptive-longitudinal-study-results-applied-to-statistical-models-to-assess-the-impact-of-early-microbiological-cultures-on-the-economic-burden-of-treatment-for-infected-diabetic-foot-ulcers-at-a-mexican-public-health-facility
#10
Luz-Ma-Adriana Balderas-Peña, Daniel Sat-Muñoz, Rosa-Emilia Ramírez-Conchas, Moisés-Roberto Alvarado-Iñiguez, Javier-Eduardo García-de-Alba-García, Eduardo Cruz-Corona, José-Luis Chávez-Hurtado, José-Martín Chagollán-Ramírez
Infection plays a critical role in health care and impacts the cost of the treatment of diabetic foot ulcers (DFU). To examine the cost reduction associated with the multidisciplinary treatment of infected DFU (IDFU) by obtaining early (ie, within 48 hours of admission) microbiological culture results, a descriptive, longitudinal study was conducted. Data were collected prospectively from patient medical charts of a cohort of 67 patients (mean age, 56.14 ± 12.3 years; mean duration of diabetes, 14.95 ± 8 years) with IDFU treated at a Mexican public health facility from January 1 to April 30, 2010...
December 2016: Ostomy/wound Management
https://www.readbyqxmd.com/read/28043667/a-sirtuin-1-mmp2-prognostic-index-for-myocardial-infarction-in-patients-with-advanced-coronary-artery-disease
#11
Ilias P Doulamis, Aspasia I Tzani, Panagiotis S Konstantopoulos, George Samanidis, Georgios Georgiopoulos, Konstantinos P Toutouzas, Despina N Perrea, Konstantinos G Perreas
BACKGROUND: Sirtuin 1 (SIRT1) appears to play a protective role against endothelial dysfunction and oxidative stress. Instead, matrix metalloproteinase 2 (MMP2) is involved in acute coronary events, by promoting tissue remodeling. This study sought to determine the clinical value of a prognostic index arising from the combination of these two biomarkers for myocardial infarction (MI) in patients with advanced coronary artery disease. METHODS: Eighty-one patients with advanced coronary artery disease planned for open heart surgery were prospectively enrolled...
December 23, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28031779/brain-derived-neurotrophic-factor-plasma-levels-and-premature-cognitive-impairment-dementia-in-type-2-diabetes
#12
Blanca Murillo Ortíz, Joel Ramírez Emiliano, Edna Ramos-Rodríguez, Sandra Martínez-Garza, Hilda Macías-Cervantes, Sergio Solorio-Meza, Texar Alfonso Pereyra-Nobara
AIM: To assess the relationship of brain-derived neurotrophic factor (BDNF) with cognitive impairment in patients with type 2 diabetes. METHODS: The study included 40 patients with diabetes mellitus type 2 (DM2), 37 patients with chronic kidney disease in hem dialysis hemodialysis therapy (HD) and 40 healthy subjects. BDNF in serum was quantified by ELISA. The Folstein Mini-Mental State Examination was used to evaluate cognitive impairment. RESULTS: The patients with DM2 and the patients in HD were categorized into two groups, with cognitive impairment and without cognitive impairment...
December 15, 2016: World Journal of Diabetes
https://www.readbyqxmd.com/read/28024454/awareness-and-perceptions-of-type-2-diabetes-risk-factors-preventability-and-complications-among-college-students-in-visakhapatnam-india
#13
Randy M Page, Elizabeth Stones, Oliver Taylor, Kendra Braudt
In India, often referred to as the "diabetes capital of the world," it is imperative to establish the level of knowledge among Asian Indians of Type 2 Diabetes (DM2) in order to plan effective public health programs aimed at prevention of DM2. Using an original survey of 983 college students in Visakhapatnam, Andhra Pradesh, we evaluated individuals' knowledge of DM2 including prevalence, risk factors, and prevention. To date, there are only a few studies that look at awareness of diabetes on the community level, and no previous studies have involved sampling college students...
January 1, 2016: International Quarterly of Community Health Education
https://www.readbyqxmd.com/read/28017255/cognitive-deficits-in-non-demented-diabetic-elderly-appear-independent-of-brain-amyloidosis
#14
Gloria C Chiang, Eileen Chang, Sneha Pandya, Amy Kuceyeski, James Hu, Richard Isaacson, Christine Ganzer, Aaron Schulman, Vivian Sobel, Shankar Vallabhajosula, Lisa Ravdin
BACKGROUND: To determine the effects of Type 2 diabetes (DM2) on levels of brain amyloidosis and cognition in a community-dwelling cohort of nondemented elderly individuals. METHODS: 33 subjects (16 DM2, 17 nondiabetic) were prospectively recruited. Subjects underwent a PET scan using the amyloid tracer, Pittsburgh Compound B, and a neuropsychological evaluation. Associations between DM2, brain amyloidosis, and cognition were assessed using multivariate regressions, adjusting for age and APOE4 status...
January 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28009489/effects-of-orchidectomy-and-testosterone-replacement-on-numbers-of-kisspeptin-neurokinin-b-and-dynorphin-a-immunoreactive-neurons-in-the-arcuate-nucleus-of-the-hypothalamus-in-obese-and-diabetic-rats
#15
M Dudek, P A Kołodziejski, E Pruszyńska-Oszmałek, K Ziarniak, J H Sliwowska
Neurons expressing kisspeptin, neurokinin B, and dynorphin A, located in the arcuate nucleus of the hypothalamus (ARC), are important regulators of reproduction. Their functions depend on metabolic and hormonal status. We hypothesized that male rats with high-fat diet-induced obesity (DIO) and/or streptozotocin-induced diabetes mellitus type 1 (DM1) and type 2 (DM2) will have: 1) alterations in numbers of immunoreactive (ir) cells: kisspeptin-ir and/or neurokinin B-ir, and dynorphin A-ir neurons in the ARC in the sham condition; 2) orchidectomy alone (ORX) and with testosterone treatment (ORX+T) will unmask possible deficits in the response of these neurons in DIO, and/or DM1 and DM2 rats...
December 23, 2016: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28001454/metabolic-health-and-long-term-safety-of-growth-hormone-treatment-in-silver-russell-syndrome
#16
C C J Smeets, J S Renes, M van der Steen, A C S Hokken-Koelega
CONTEXT: Children with Silver-Russell syndrome (SRS) are born small for gestational age (SGA) and remain short. Growth hormone (GH)-treatment improves height in short SGA children, including those with SRS. Data on metabolic health and long-term safety of GH-treatment in SRS are lacking. OBJECTIVE: To investigate metabolic health in SRS patients during and until two years after discontinuation of GH-treatment. DESIGN: Metabolic health was assessed longitudinally at GH-start, GH-stop, and six months and two years thereafter...
December 21, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27992942/cardiac-abnormalities-in-congenital-and-childhood-myotonic-muscular-dystrophy-type-1
#17
Anjali Sharma, Sandeep Singh, Shri K Mishra
Myotonic dystrophy often presents with cardiac abnormalities, particularly conduction defects, that factor into an increased risk of sudden cardiac death. Myotonic dystrophy has two forms, myotonic dystrophy type 1 (DM1) and DM2, and is a multisystemic disorder that presents in a wide, clinical spectrum and age range. A distinguishing feature of DM1 is the existence of a congenital form. Though research on cardiac involvement has been conducted on patients with the adult form of myotonic dystrophy, there have been few studies focused on cardiac involvement in pediatric patients with congenital myotonic dystrophy type 1 (CDM1)...
December 19, 2016: Neuropediatrics
https://www.readbyqxmd.com/read/27992506/menstrual-cycle-irregularity-and-metabolic-disorders-a-population-based-prospective-study
#18
Marzieh Rostami Dovom, Fahimeh Ramezani Tehrani, Shirin Djalalinia, Leila Cheraghi, Samira Behboudi Gandavani, Fereidoun Azizi
The regularity of menstrual cycles is considered an indicator of women's reproductive health. Previous studies with a cross-sectional design have documented the relationship between menstrual cycle irregularities, insulin-resistance and the future risks for metabolic disorders. Limited data documented by prospective studies can lead to premature conclusions regarding the relationship between menstrual cycle irregularities and other conditions influencing women's health. The present study therefore, using a prospective design aimed to assess the risk of metabolic disorders in women with a history of irregular menstrual cycles, was based on the data gathered from the Tehran Lipid and Glucose study (TLGS) an ongoing prospective cohort study initiated in 1999...
2016: PloS One
https://www.readbyqxmd.com/read/27975100/hyperglycemia-suppresses-microrna-expression-in-platelets-to-increase-p2ry12-and-selp-levels-in-type-2-diabetes-mellitus
#19
Zsolt Fejes, Szilárd Póliska, Zsolt Czimmerer, Miklós Káplár, András Penyige, Gabriella Gál Szabó, Ildikó Beke Debreceni, Satya P Kunapuli, János Kappelmayer, Béla Nagy
Megakaryocyte (MK)-derived miRNAs have been detected in platelets. Here, we analysed the expression of platelet and circulating miR-223, miR-26b, miR-126 and miR-140 that might be altered with their target mRNAs in type 2 diabetes mellitus (DM2). MiRNAs were isolated from leukocyte-depleted platelets and plasma samples obtained from 28 obese DM2, 19 non-DM obese and 23 healthy individuals. The effect of hyperglycaemia on miRNAs was also evaluated in MKs using MEG-01 and K562 cells under hyperglycaemic conditions after 8 hours up to four weeks...
December 15, 2016: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/27972219/quality-of-life-qol-and-health-utility-ut-in-patients-with-type-2-diabetes-mellitus-dm2-receiving-different-oral-hypoglycemic-therapy-in-a-real-world-setting
#20
T Ionova, T Nikitina, A Rodionova, K Kurbatova
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
keyword
keyword
59498
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"