keyword
MENU ▼
Read by QxMD icon Read
search

DM2

keyword
https://www.readbyqxmd.com/read/29453673/optical-coherence-tomography-angiography-discerns-preclinical-diabetic-retinopathy-in-eyes-of-patients-with-type-2-diabetes-without-clinical-diabetic-retinopathy
#1
Dan Cao, Dawei Yang, Zhongning Huang, Yunkao Zeng, Jun Wang, Yunyan Hu, Liang Zhang
AIMS: To investigate changes in retinal vascular plexuses and choriocapillaris in patients with type 2 diabetes mellitus (DM2) without diabetic retinopathy (DR) and healthy controls using optical coherence tomography angiography (OCTA). METHODS: A total of 71 DM2 and 67 healthy control subjects were included. All subjects underwent OCTA examination (RTVue-XR Avanti; Optovue, Fremont, CA, USA). Average vessel density in superficial capillary plexus (SCP), deep capillary plexus (DCP) and choriocapillaris, parafoveal vessel density in SCP and DCP, FAZ area (mm 2 ) in SCP, microaneurysms and capillary nonperfusion were taken into analysis...
February 16, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29448118/calcium-channel-blockers-as-drug-repurposing-candidates-for-gestational-diabetes-mining-large-scale-genomic-and-electronic-health-records-data-to-repurpose-medications
#2
Jeffery A Goldstein, Lisa A Bastarache, Joshua C Denny, Dan M Roden, Jill M Pulley, David M Aronoff
New therapeutic approaches are needed for gestational diabetes mellitus (GDM), but must show safety and efficacy in a historically understudied population. We studied associations between electronic medical record (EMR) phenotypes and genetic variants to uncover drugs currently considered safe in pregnancy that could treat or prevent GDM. We identified 129 systemically active drugs considered safe in pregnancy targeting the proteins produced from 196 genes. We tested for associations between GDM and/or type 2 diabetes (DM2) and 306 SNPs in 130 genes represented on the Illumina Infinium Human Exome Bead Chip (DM2 was included due to shared pathophysiological features with GDM)...
February 12, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29439834/-treatment-of-type-2-diabetes-mellitus-in-elderly-patients
#3
R Gómez-Huelgas, F Gómez Peralta, L Rodríguez Mañas, F Formiga, M Puig Domingo, J J Mediavilla Bravo, C Miranda, J Ena
The prevalence of type 2 diabetes mellitus (DM2) increases markedly with age. Antidiabetic treatment and the objectives of glycaemic control in elderly patients with DM2 should be individualised according to their biopsychosocial characteristics. In elderly patients for whom the benefits of intensive antidiabetic treatment are limited, the basic objectives should be to improve the quality of life, preserve functionality and avoid adverse effects, especially hypoglycaemia. Treatment of DM2 in the elderly was the subject of a consensus document published in 2012 and endorsed by several Spanish scientific societies...
February 10, 2018: Revista Española de Geriatría y Gerontología
https://www.readbyqxmd.com/read/29432933/arterial-stiffening-and-thickening-in-patients-with-pseudoxanthoma-elasticum
#4
Guido Kranenburg, Frank L J Visseren, Gert Jan de Borst, Pim A de Jong, Wilko Spiering
BACKGROUND AND AIMS: Patients with pseudoxanthoma elasticum (PXE), a monogenetic calcification disease, are at high vascular risk. Although the precise arterial phenotype remains unestablished, it is hypothesized that PXE predominantly affects the medial arterial layer leading to arterial stiffening. We aimed to test this hypothesis by measuring arterial wall characteristics in PXE and comparisons with the general population and diabetes mellitus type 2 (DM2), a condition typically associated with mixed intimal and medial arterial disease...
February 9, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29422748/effectiveness-of-music-therapy-on-focused-attention-working-memory-and-stress-in-type-2-diabetes-an-exploratory-study
#5
Indira Tumuluri, Shantala Hegde, H R Nagendra
Cognitive deficits are reported in diabetes mellitus type 2 (DM2). Previous research has shown that music-based intervention can not only reduce hyperglycemia but also target cognitive functions as well as stress. The aim of this exploratory study was to understand the effect of active participation in music therapy (MT) on the cognitive deficits of DM2 patients. MT of twenty sessions was carried out with three participants with DM2. Serum cortisol, perceived stress, Color Trail Test (1 and 2), and verbal n-back (1 and 2) tests were used to measure the outcomes...
September 2017: International Journal of Yoga
https://www.readbyqxmd.com/read/29412387/relationships-between-adiponectin-levels-the-metabolic-syndrome-and-type-2-diabetes-a-literature-review
#6
Anize Delfino von Frankenberg, André F Reis, Fernando Gerchman
Elevated hepatic glucose production, impaired insulin secretion, and insulin resistance - abnormalities of glucose metabolism typically found in subjects with obesity - are major factors underlying the pathogenesis of type 2 diabetes (DM2) and the metabolic syndrome (MS). Adiponectin is a major regulator of glucose and lipid homeostasis via its insulin-sensitizing properties, and lower levels seems to be associated with the development of DM2 and MS. The purpose of this review is to clarify the mechanisms whereby adiponectin relates to the development of DM2 and MS and the association between polymorphisms of the adiponectin gene, circulating levels of the hormone, and its relationships with DM2...
December 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29407525/numerical-modeling-of-fluid-and-oxygen-exchanges-through-microcirculation-for-the-assessment-of-microcirculation-alterations-caused-by-type-2-diabetes
#7
Yuanliang Tang, Ying He
Type 2 diabetes mellitus (DM2) is frequently accompanied by microcirculation complications, including structural and functional alterations, which may have serious effects on substance exchanges between blood and interstitial tissue and the health of organs. In this paper, we aim to study the influence of microcirculation alterations in DM2 patients on fluid and oxygen exchanges through a model analysis. A fluid flow and oxygen transport model were developed by considering the interplay between blood in capillary network and interstitial tissue...
February 2, 2018: Microvascular Research
https://www.readbyqxmd.com/read/29398232/identification-of-new-candidate-genes-for-retinopathy-in-type-2-diabetics-valencia-study-on-diabetic-retinopathy-vsdr-report-number-3
#8
M D Pinazo-Durán, K Shoaie-Nia, S M Sanz-González, J Raga-Cervera, J J García-Medina, M I López-Gálvez, D Galarreta-Mira, L Duarte, C Campos-Borges, V Zanón-Moreno
OBJECTIVE: To identify genes involved in the pathogenic mechanisms of non-proliferative diabetic retinopathy (NPDR), among which include oxidative stress, extracellular matrix changes, and/or apoptosis, in order to evaluate the risk of developing this retinal disease in a type2 diabetic (DM2) population. MATERIAL AND METHODS: A case-control study was carried out on 81 participants from the Valencia Study on Diabetic Retinopathy (VSDR) of both genders, with ages 25-85years...
February 1, 2018: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/29384876/predictors-of-completing-a-primary-health-care-diabetes-prevention-intervention-programme-in-people-at-high-risk-of-type-2-diabetes-experiences-of-the-de-plan-project
#9
Aleksandra Gilis-Januszewska, Jaana Lindström, Noël C Barengo, Jaakko Tuomilehto, Peter Eh Schwarz, Ewa Wójtowicz, Beata Piwońska-Solska, Zbigniew Szybiński, Adam Windak, Alicja Hubalewska-Dydejczyk
It has been shown that real-life implementation studies for the prevention of type 2 diabetes (DM2) performed in different settings and populations can be effective. However, not enough information is available on factors influencing the reach of DM2 prevention programmes. This study examines the predictors of completing an intervention programme targeted at people at high risk of DM2 in Krakow, Poland as part of the DE-PLAN project.A total of 262 middle-aged people, everyday patients of 9 general practitioners' (GP) practices, at high risk of DM2 (Finnish Diabetes Risk Score (FINDRISK) >14) agreed to participate in the lifestyle intervention to prevent DM2...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29369516/prevalence-of-optical-coherence-tomography-detected-vitreomacular-interface-disorders-the-maastricht-study
#10
Ilona Liesenborghs, Eline E B De Clerck, Tos T J M Berendschot, Fleur Goezinne, Miranda T Schram, Ronald M A Henry, Coen D A Stehouwer, Carroll A B Webers, Jan S A G Schouten
PURPOSE: To calculate the prevalence of all vitreomacular interface (VMI) disorders and stratify according to age, sex and (pre)diabetes status. METHODS: The presence of VMI disorders was assessed in 2660 participants aged between 40 and 75 years from The Maastricht Study who had a gradable macular spectral-domain optical coherence tomography (SD-OCT) volume scan in at least one eye [mean 59.7 ± 8.2 years, 50.2% men, 1531 normal glucose metabolism (NGM), 401 prediabetes, 728 type 2 diabetes (DM2, oversampled)]...
January 25, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29366502/treatment-of-type-2-diabetes-mellitus-in-elderly-patients
#11
R Gómez-Huelgas, F Gómez Peralta, L Rodríguez Mañas, F Formiga, M Puig Domingo, J J Mediavilla Bravo, C Miranda, J Ena
The prevalence of type 2 diabetes mellitus (DM2) increases markedly with age. Antidiabetic treatment and the objectives of glycaemic control in elderly patients with DM2 should be individualised according to their biopsychosocial characteristics. In elderly patients for whom the benefits of intensive antidiabetic treatment are limited, the basic objectives should be to improve the quality of life, preserve functionality and avoid adverse effects, especially hypoglycaemia. Treatment of DM2 in the elderly was the subject of a consensus document published in 2012 and endorsed by several Spanish scientific societies...
January 21, 2018: Revista Clínica Española
https://www.readbyqxmd.com/read/29363480/development-and-validation-of-a-questionnaire-for-assessing-the-characteristics-of-diet-and-physical-activity-in-patients-with-type-2-diabetes
#12
Rubén Martín Payo, Xana González Méndez, Cristina Papín Cano, Javier Suárez Álvarez
BACKGROUND: The aim ofthis study was to explore the psychometric properties of the Motiva.Diaf-DM2 questionnaire, which assesses adherence to a healthy diet and physical activity in patients with Type 2 Diabetes (T2D). METHOD: Participants were 206 patients who attended primary care services, with a mean age of 69.63 years (SD = 11.05), with 39.3% of the participants being women. To assess the test-retest reliability of the measure, a random subsample (n = 40) of patients who had another appointment scheduled was selected to fill in the questionnaire once again two weeks after the initial administration...
February 2018: Psicothema
https://www.readbyqxmd.com/read/29343467/hearing-impairment-in-patients-with-myotonic-dystrophy-type-2
#13
Judith van Vliet, Alide A Tieleman, Baziel G M van Engelen, Guillaume Bassez, Laurent Servais, Anthony Béhin, Tanya Stojkovic, Jan Meulstee, Joost A M Engel, George Lamas, Bruno Eymard, Wim I M Verhagen, Elisabeth Mamelle
OBJECTIVE: To systematically assess auditory characteristics of a large cohort of patients with genetically confirmed myotonic dystrophy type 2 (DM2). METHODS: Patients with DM2 were included prospectively in an international cross-sectional study. A structured interview about hearing symptoms was held. Thereafter, standardized otologic examination, pure tone audiometry (PTA; 0.25, 0.5, 1, 2, 4, and 8 kHz), speech audiometry, tympanometry, acoustic middle ear muscle reflexes, and brainstem auditory evoked potentials (BAEP) were performed...
January 17, 2018: Neurology
https://www.readbyqxmd.com/read/29340447/-why-don-t-doctors-use-early-insulinization-therapy-in-patients-with-diabetes-mellitus-type-2-a-qualitative-approach-in-a-mexican-city
#14
Roberto Lagunes-Córdoba, Isaac Galindo-Guevara, Atalia Castillo Reyes, Citlalli Romero-Aparicio, Francisco Javier Rosas-Santiago
Early insulinization therapy is regarded as an efficient aid to improve long term control and quality of life in patients with diabetes mellitus type 2 (DM2). Nevertheless, both patients and medical staff confront barriers in using this therapeutic tool. This study employs a qualitative approach to explore the barriers to early insulinization among medical staff from the public sector in the city of Xalapa, Veracruz, México. Between 2015 and 2016, in-depth interviews were conducted with general and specialist physicians offering primary health care to patients with DM2...
October 2017: Salud Colectiva
https://www.readbyqxmd.com/read/29332034/microhemodynamic-indices-to-evaluate-the-effectiveness-of-herbal-medicine-in-diabetes-a-comparison-between-alpha-mangostin-and-curcumin-in-the-retina-of-type-2-diabetic-rats
#15
Amporn Jariyapongskul, Chonticha Areebambud, Niimi Hideyuki
OBJECTIVE: This study was aimed to develop microhemodynamic indices to evaluate the effectiveness of herbal medicine in diabetic tissues. METHODS: Male Sprague-Dawley rats were divided into four groups: normal control rats (Control), type 2 diabetic rats without (DM2) and with supplementation of alpha mangostin (DM2-MG) or curcumin (DM2-CUR). Alpha-mangostin or curcumin (200 mg/kg BW) were fed followed by i.p. injection of streptozotocin (STZ). Mean arterial pressure (MAP) and retinal blood flow (RBF) were measured and retinal flow resistance (RFR) was calculated...
January 10, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29331264/altered-levels-of-the-splicing-factor-muscleblind-modifies-cerebral-cortical-function-in-mouse-models-of-myotonic-dystrophy
#16
Gang Chen, Russell E Carter, John D Cleary, Tammy S Reid, Laura P Ranum, Maurice S Swanson, Timothy J Ebner
Myotonic dystrophy (DM) is a progressive, multisystem disorder affecting skeletal muscle, heart, and central nervous system. In both DM1 and DM2, microsatellite expansions of CUG and CCUG RNA repeats, respectively, accumulate and disrupt functions of alternative splicing factors, including muscleblind (MBNL) proteins. Grey matter loss and white matter changes, including the corpus callosum, likely underlie cognitive and executive function deficits in DM patients. However, little is known how cerebral cortical circuitry changes in DM...
January 10, 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/29325606/repeat-expansion-diseases
#17
Henry Paulson
More than 40 diseases, most of which primarily affect the nervous system, are caused by expansions of simple sequence repeats dispersed throughout the human genome. Expanded trinucleotide repeat diseases were discovered first and remain the most frequent. More recently tetra-, penta-, hexa-, and even dodeca-nucleotide repeat expansions have been identified as the cause of human disease, including some of the most common genetic disorders seen by neurologists. Repeat expansion diseases include both causes of myotonic dystrophy (DM1 and DM2), the most common genetic cause of amyotrophic lateral sclerosis/frontotemporal dementia (C9ORF72), Huntington disease, and eight other polyglutamine disorders, including the most common forms of dominantly inherited ataxia, the most common recessive ataxia (Friedreich ataxia), and the most common heritable mental retardation (fragile X syndrome)...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29314079/the-high-frequency-of-monoclonal-gammopathy-in-patients-with-diabetic-sensorimotor-polyneuropathy
#18
Alon Abraham, Carolina Barnett, Hans D Katzberg, Leif E Lovblom, A Perkins Bruce, Vera Bril
INTRODUCTION: Monoclonal gammopathy has been reported in several polyneuropathies. In this study, we aimed to explore the frequency and characteristics of monoclonal gammopathy in patients with diabetic sensorimotor polyneuropathy (DSP). METHODS: Patients with type 1 and 2 diabetes mellitus (DM 1, DM 2), and controls without diabetes, were evaluated between November 2008 and December 2013. RESULTS: 50 controls, 66 patients with DM 1, and 106 patients with DM 2, were included, with an average age of 43 ± 18, 45 ± 17, and 65 ± 10 years respectively...
January 4, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29303519/teaching-an-old-scaffold-new-recognition-tricks-oligopyrrolamide-antagonists-of-iapp-aggregation
#19
Sunil Kumar, Maria C Vogel, Andrew D Hamilton
A library of N-substituted oligopyrrolamides was designed to modulate the aggregation kinetics of islet amyloid polypeptide (IAPP). IAPP is a hormonal peptide, co-secreted with insulin in the pancreatic β-cells. IAPP samples a variety of conformations, starting from a native random coil to membrane-associated α-helical intermediates and eventually terminates in the amyloid plaques rich in β-sheet structures. A growing body of evidence suggests that membrane bound α-helical intermediates are the key cytotoxic species that impair the functionality and viability of β-cells and contribute to the onset of type 2 diabetes mellitus (DM2)...
January 5, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29295869/macrophage-activation-marker-scd163-correlates-with-accelerated-lipolysis-following-lps-exposure-a-human-randomised-clinical-trial
#20
Nikolaj Rittig, Mads Svart, Niels Jessen, Niels Møller, Holger J Møller, Henning Grønbæk
BACKGROUND: Macrophage activation determined by levels of soluble sCD163 is associated with obesity, insulin resistance, diabetes mellitus type 2 (DM2) and non-alcoholic fatty liver disease (NAFLD). This suggests that macrophage activation is involved in the pathogenesis of conditions is characterised by adaptions in the lipid metabolism. Since sCD163 is shed to serum by inflammatory signals including lipopolysaccharides (LPS, endotoxin), we investigated sCD163 and correlations with lipid metabolism following LPS exposure...
January 2018: Endocrine Connections
keyword
keyword
59498
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"