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Jeffrey Carlson

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https://www.readbyqxmd.com/read/29772801/ogt-o-glcnac-transferase-selectively-modifies-multiple-residues-unique-to-lamin-a
#1
Dan N Simon, Amanda Wriston, Qiong Fan, Jeffrey Shabanowitz, Alyssa Florwick, Tejas Dharmaraj, Sherket B Peterson, Yosef Gruenbaum, Cathrine R Carlson, Line M Grønning-Wang, Donald F Hunt, Katherine L Wilson
The LMNA gene encodes lamins A and C with key roles in nuclear structure, signaling, gene regulation, and genome integrity. Mutations in LMNA cause over 12 diseases ('laminopathies'). Lamins A and C are identical for their first 566 residues. However, they form separate filaments in vivo, with apparently distinct roles. We report that lamin A is β- O -linked N -acetylglucosamine- (O -GlcNAc)-modified in human hepatoma (Huh7) cells and in mouse liver. In vitro assays with purified O -GlcNAc transferase (OGT) enzyme showed robust O -GlcNAcylation of recombinant mature lamin A tails (residues 385⁻646), with no detectable modification of lamin B1, lamin C, or 'progerin' (Δ50) tails...
May 17, 2018: Cells
https://www.readbyqxmd.com/read/29606504/a-chimeric-antibody-against-ackr3-cxcr7-in-combination-with-tmz-activates-immune-responses-and-extends-survival-in-mouse-gbm-models
#2
Nicole Salazar, Jeffrey C Carlson, Kexin Huang, Yayue Zheng, Cecilia Oderup, Julia Gross, Andrew D Jang, Thomas M Burke, Susanna Lewén, Alexander Scholz, Serina Huang, Leona Nease, Jon Kosek, Michel Mittelbronn, Eugene C Butcher, Hua Tu, Brian A Zabel
Glioblastoma (GBM) is the least treatable type of brain tumor, afflicting over 15,000 people per year in the United States. Patients have a median survival of 16 months, and over 95% die within 5 years. The chemokine receptor ACKR3 is selectively expressed on both GBM cells and tumor-associated blood vessels. High tumor expression of ACKR3 correlates with poor prognosis and potential treatment resistance, making it an attractive therapeutic target. We engineered a single chain FV-human FC-immunoglobulin G1 (IgG1 ) antibody, X7Ab, to target ACKR3 in human and mouse GBM cells...
March 6, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29601021/deuterated-silicon-nitride-photonic-devices-for-broadband-optical-frequency-comb-generation
#3
Jeff Chiles, Nima Nader, Daniel D Hickstein, Su Peng Yu, Travis Crain Briles, David Carlson, Hojoong Jung, Jeffrey M Shainline, Scott Diddams, Scott B Papp, Sae Woo Nam, Richard P Mirin
We report and characterize low-temperature, plasma-deposited deuterated silicon nitride films for nonlinear integrated photonics. With a peak processing temperature less than 300°C, it is back-end compatible with complementary metal-oxide semiconductor substrates. We achieve microresonators with a quality factor of up to 1.6×106 at 1552 nm and >1.2×106 throughout λ=1510-1600  nm, without annealing or stress management (film thickness of 920 nm). We then demonstrate the immediate utility of this platform in nonlinear photonics by generating a 1 THz free-spectral-range, 900 nm bandwidth modulation-instability microresonator Kerr comb and octave-spanning, supercontinuum-broadened spectra...
April 1, 2018: Optics Letters
https://www.readbyqxmd.com/read/29589272/embedding-autism-spectrum-disorder-diagnosis-within-the-medical-home-decreasing-wait-times-through-streamlined-assessment
#4
Jeffrey F Hine, Catherine G Herrington, Alice M Rothman, Rachel L Mace, Barron L Patterson, Kathryn L Carlson, Zachary E Warren
Long waits for diagnostic assessment prevent early identification of children suspected of having autism spectrum disorder. We evaluated the benefit of embedded diagnostic consultation within primary care clinics. Using a streamlined diagnostic model, 119 children with concerns for autism spectrum disorder were seen over 14 months. Diagnostic clarity was determined through streamlined assessment for 59% of the children, while others required follow-up. Latency from first concern to diagnosis was 55 days and median age at diagnosis was 32 months: considerably lower than national averages or comparable tertiary clinics...
March 27, 2018: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29561717/implementation-of-a-standardized-data-collection-system-for-comprehensive-appraisal-of-cleft-care
#5
Peter G Bittar, Anna R Carlson, Ann Mabie-DeRuyter, Jeffrey R Marcus, Alexander C Allori
OBJECTIVE: Our objective is to describe the process of adapting a conceptual framework into a practical toolkit for one cleft team. DESIGN: This is a single-arm implementation study in a single institution. SETTING: Implementation took place at a mid-sized multidisciplinary clinic for patients with cleft lip and/or palate (CL/P) from urban/suburban and rural areas across North Carolina and neighboring states. PARTICIPANTS: Eligible participants were patients with CL/P from English-speaking families...
January 1, 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29533339/facial-nerve-trauma-a-call-for-minimum-reporting-guidelines
#6
Prasanth Pattisapu, Malia Gresham, Tyler McElwee, Jeffrey T Vrabec, Matthew L Carlson, Alex D Sweeney
No abstract text is available yet for this article.
April 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29518432/perioperative-immunonutrition-modulates-inflammatory-response-after-radical-cystectomy-results-of-a-pilot-randomized-controlled-clinical-trial
#7
Jill M Hamilton-Reeves, Abigail Stanley, Misty D Bechtel, Thomas M Yankee, Prabhakar Chalise, Lauren K Hand, Eugene K Lee, Woodson Smelser, Moben Mirza, Hadley Wyre, Holly Hull, Susan E Carlson, Jeffrey M Holzbeierlein
PURPOSE: Poor preoperative nutritional status is associated with a higher complication rate after radical cystectomy in patients with bladder cancer. Given the short interval between diagnosis and radical cystectomy, we compared the effect of short-term specialized immunonutrition to that of a standard oral nutritional supplement on the acute inflammatory response and arginine status in patients treated with radical cystectomy. MATERIALS AND METHODS: In this prospective, randomized study in 29 men 14 received specialized immunonutrition and 15 received oral nutritional supplement...
March 6, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29486497/physiological-approach-to-sodium-supplementation-in-preterm-infants
#8
David E Segar, Elizabeth K Segar, Lyndsay A Harshman, John M Dagle, Susan J Carlson, Jeffrey L Segar
OBJECTIVE:  To implement and evaluate a clinical practice algorithm to identify preterm infants with sodium deficiency and guide sodium supplementation based on urine sodium concentrations. STUDY DESIGN:  Urine sodium concentration was measured in infants born at 260/7 to 296/7 weeks' gestation at 2-week intervals. Sodium supplementation was based on the urine sodium algorithm. Growth and respiratory outcomes in this cohort were compared with a matched cohort cared for in our neonatal intensive care unit prior to algorithm implementation (2014-2015 cohort)...
February 27, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29472366/competitive-resource-allocation-to-metabolic-pathways-contributes-to-overflow-metabolisms-and-emergent-properties-in-cross-feeding-microbial-consortia
#9
REVIEW
Ross P Carlson, Ashley E Beck, Poonam Phalak, Matthew W Fields, Tomas Gedeon, Luke Hanley, William R Harcombe, Michael A Henson, Jeffrey J Heys
Resource scarcity is a common stress in nature and has a major impact on microbial physiology. This review highlights microbial acclimations to resource scarcity, focusing on resource investment strategies for chemoheterotrophs from the molecular level to the pathway level. Competitive resource allocation strategies often lead to a phenotype known as overflow metabolism; the resulting overflow byproducts can stabilize cooperative interactions in microbial communities and can lead to cross-feeding consortia...
April 17, 2018: Biochemical Society Transactions
https://www.readbyqxmd.com/read/29437158/dataset-of-human-medial-temporal-lobe-single-neuron-activity-during-declarative-memory-encoding-and-recognition
#10
Mailys C M Faraut, April A Carlson, Shannon Sullivan, Oana Tudusciuc, Ian Ross, Chrystal M Reed, Jeffrey M Chung, Adam N Mamelak, Ueli Rutishauser
We present a dataset of 1,576 single neurons recorded from the human amygdala and hippocampus in 65 sessions from 42 patients undergoing intracranial monitoring for localization of epileptic seizures. Subjects performed a recognition memory task with pictures as stimuli. Subjects were asked to identify whether they had seen a particular image the first time ('new') or second time ('old') on a 1-6 confidence scale. This comprehensive dataset includes the spike times of all neurons and their extracellular waveforms, behavior, electrode locations determined from post-operative MRI scans, demographics, and the stimuli shown...
February 13, 2018: Scientific Data
https://www.readbyqxmd.com/read/29406754/one-step-synthesis-of-tunable-size-gold-nanoplates-on-graphene-multilayers
#11
Wenbo Xin, Joseph Severino, Igor M De Rosa, Dian Yu, Jeffrey Mckay, Peiyi Ye, Xunqian Yin, Jenn-Ming Yang, Larry Carlson, Suneel Kodambaka
Au nanoplates (quasi-two-dimensional single crystals) are most commonly synthesized using a mixture of Au precursors via approaches involving multiple processing steps and the use of seed crystals. Here, we report the synthesis of truncated-hexagonal {111}-oriented micrometer-scale Au nanoplates on graphene multilayers using only potassium tetrabromoaurate (KAuBr4 ) as the precursor. We demonstrate that the nanoplate sizes can be controllably varied from tens of nanometers up to a few micrometers by introducing desired concentrations of chloroauric acid (HAuCl4 ) to KAuBr4 and their thicknesses from ∼13 to ∼46 nm with the synthesis time...
March 14, 2018: Nano Letters
https://www.readbyqxmd.com/read/29393267/theoretical-effect-of-dbs-on-axonal-fibers-of-passage-firing-rates-entropy-and-information-content
#12
Jeffrey E Arle, Longzhi Z Mei, Kristen W Carlson, Jay L Shils
BACKGROUND: Deep brain stimulation (DBS) has effects on axons that originate and terminate outside the DBS target area. OBJECTIVE: We hypothesized that DBS generates action potentials (APs) in both directions in "axons of passage," altering their information content and that of all downstream cells and circuits, and sought to quantify the change in fiber information content. METHODS: We incorporated DBS parameters (fiber firing frequency and refractory time, and AP initiation location along the fiber and propagation velocity) in a filtering function determining the AP frequency reaching the postsynaptic cell...
2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29345493/jon-douglas-carlson-1945-2017
#13
Matt Englar-Carlson, Jeffrey Kottler
Presents an obituary for Jon Douglas Carlson, who passed away on February 1, 2017, in Madison, Wisconsin, due to complications from a bone marrow transplant. Jon was a leading figure within counseling, psychology, and education, with a specific focus on Adlerian theory and practice. His professional work was informed by over 40 years of clinical practice. During his distinguished career, he published 64 books, 185 articles, and more than 300 training videos adopted by universities around the world. Carlson's professional legacy lives on through the many books and countless hours of professional video sessions, as well as through the healthy, engaged lives of the clients, students, and colleagues that he encouraged, mentored, and supported...
January 2018: American Psychologist
https://www.readbyqxmd.com/read/29306730/role-of-metabolic-syndrome-on-perioperative-and-oncological-outcomes-at-radical-prostatectomy-in-a-low-risk-prostate-cancer-cohort-potentially-eligible-for-active-surveillance
#14
Michele Colicchia, Alessandro Morlacco, Laureano J Rangel, Rachel E Carlson, Fabrizio Dal Moro, R Jeffrey Karnes
BACKGROUND: Metabolic syndrome (MetS) is considered a potential risk factor for adverse outcomes after radical prostatectomy (RP). Furthermore, studies about the effect of MetS on low-risk prostate cancer (PCa) and its implications in active surveillance (AS) are limited. OBJECTIVE: To investigate the role of MetS (using International Diabetes Federation-American Heart Association/National Heart, Lung, and Blood Institute criteria) on perioperative and oncological outcomes after RP in low-risk PCa and in a subgroup potentially eligible for AS...
January 3, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29302013/elevated-hla-a-expression-impairs-hiv-control-through-inhibition-of-nkg2a-expressing-cells
#15
Veron Ramsuran, Vivek Naranbhai, Amir Horowitz, Ying Qi, Maureen P Martin, Yuko Yuki, Xiaojiang Gao, Victoria Walker-Sperling, Gregory Q Del Prete, Douglas K Schneider, Jeffrey D Lifson, Jacques Fellay, Steven G Deeks, Jeffrey N Martin, James J Goedert, Steven M Wolinsky, Nelson L Michael, Gregory D Kirk, Susan Buchbinder, David Haas, Thumbi Ndung'u, Philip Goulder, Peter Parham, Bruce D Walker, Jonathan M Carlson, Mary Carrington
The highly polymorphic human leukocyte antigen ( HLA ) locus encodes cell surface proteins that are critical for immunity. HLA-A expression levels vary in an allele-dependent manner, diversifying allele-specific effects beyond peptide-binding preference. Analysis of 9763 HIV-infected individuals from 21 cohorts shows that higher HLA-A levels confer poorer control of HIV. Elevated HLA-A expression provides enhanced levels of an HLA-A-derived signal peptide that specifically binds and determines expression levels of HLA-E, the ligand for the inhibitory NKG2A natural killer (NK) cell receptor...
January 5, 2018: Science
https://www.readbyqxmd.com/read/29229396/albeit-nocturnal-rats-subjected-to-traumatic-brain-injury-do-not-differ-in-neurobehavioral-performance-whether-tested-during-the-day-or-night
#16
Peter J Niesman, Jiahui Wei, Megan J LaPorte, Lauren J Carlson, Kileigh L Nassau, Gina C Bao, Jeffrey P Cheng, Patricia de la Tremblaye, Naima Lajud, Corina O Bondi, Anthony E Kline
Behavioral assessments in rats are overwhelmingly conducted during the day, albeit that is when they are least active. This incongruity may preclude optimal performance. Hence, the goal of this study was to determine if differences in neurobehavior exist in traumatic brain injured (TBI) rats when assessed during the day vs. night. The hypothesis was that the night group would perform better than the day group on all behavioral tasks. Anesthetized adult male rats received either a cortical impact or sham injury and then were randomly assigned to either Day (1:00-3:00p...
February 5, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29167877/utility-of-imaging-based-biomarkers-for-glutamate-targeted-drug-development-in-psychotic-disorders-a-randomized-clinical-trial
#17
Daniel C Javitt, Cameron S Carter, John H Krystal, Joshua T Kantrowitz, Ragy R Girgis, Lawrence S Kegeles, John D Ragland, Richard J Maddock, Tyler A Lesh, Costin Tanase, Philip R Corlett, Douglas L Rothman, Graeme Mason, Maolin Qiu, James Robinson, William Z Potter, Marlene Carlson, Melanie M Wall, Tse-Hwei Choo, Jack Grinband, Jeffrey A Lieberman
Importance: Despite strong theoretical rationale and preclinical evidence, several glutamate-targeted treatments for schizophrenia have failed in recent pivotal trials, prompting questions as to target validity, compound inadequacy, or lack of target engagement. A key limitation for glutamate-based treatment development is the lack of functional target-engagement biomarkers for translation between preclinical and early-stage clinical studies. We evaluated the utility of 3 potential biomarkers-ketamine-evoked changes in the functional magnetic imaging (fMRI) blood oxygen level-dependent response (pharmacoBOLD), glutamate proton magnetic resonance spectroscopy (1H MRS), and task-based fMRI-for detecting ketamine-related alterations in brain glutamate...
January 1, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29136340/nomenclature-of-cutaneous-vasculitis-dermatologic-addendum-to-the-2012-revised-international-chapel-hill-consensus-conference-nomenclature-of-vasculitides
#18
Cord H Sunderkötter, Bernhard Zelger, Ko-Ron Chen, Luis Requena, Warren Piette, J Andrew Carlson, Jan Dutz, Peter Lamprecht, Alfred Mahr, Elisabeth Aberer, Victoria P Werth, David A Wetter, Seiji Kawana, Raashid Luqmani, Camille Frances, Joseph Jorizzo, J Richard Watts, Dieter Metze, Marzia Caproni, Erkan Alpsoy, Jeffrey P Callen, David Fiorentino, Peter A Merkel, Ronald J Falk, J Charles Jennette
OBJECTIVE: To prepare a dermatologic addendum to the 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides (CHCC2012) to address vasculitides affecting the skin (D-CHCC). The goal was to standardize the names and definitions for cutaneous vasculitis. METHODS: A nominal group technique with a facilitator was used to reach consensus on the D-CHCC nomenclature, using multiple face-to-face meetings, e-mail discussions, and teleconferences...
February 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29124805/identification-of-16q21-as-a-modifier-of-nonsyndromic-orofacial-cleft-phenotypes
#19
Jenna C Carlson, Jennifer Standley, Aline Petrin, John R Shaffer, Azeez Butali, Carmen J Buxó, Eduardo Castilla, Kaare Christensen, Frederic W-D Deleyiannis, Jacqueline T Hecht, L Leigh Field, Ariuntuul Garidkhuu, Lina M Moreno Uribe, Natsume Nagato, Ieda M Orioli, Carmencita Padilla, Fernando Poletta, Satoshi Suzuki, Alexandre R Vieira, George L Wehby, Seth M Weinberg, Terri H Beaty, Eleanor Feingold, Jeffrey C Murray, Mary L Marazita, Elizabeth J Leslie
Orofacial clefts (OFCs) are common, complex birth defects with extremely heterogeneous phenotypic presentations. Two common subtypes-cleft lip alone (CL) and CL plus cleft palate (CLP)-are typically grouped into a single phenotype for genetic analysis (i.e., CL with or without cleft palate, CL/P). However, mounting evidence suggests there may be unique underlying pathophysiology and/or genetic modifiers influencing expression of these two phenotypes. To this end, we performed a genome-wide scan for genetic modifiers by directly comparing 450 CL cases with 1,692 CLP cases from 18 recruitment sites across 13 countries from North America, Central or South America, Asia, Europe, and Africa...
December 2017: Genetic Epidemiology
https://www.readbyqxmd.com/read/29079709/hif2%C3%AE-targeted-rnai-therapeutic-inhibits-clear-cell-renal-cell-carcinoma
#20
So C Wong, Weijun Cheng, Holly Hamilton, Anthony L Nicholas, Darren H Wakefield, Aaron Almeida, Andrei V Blokhin, Jeffrey Carlson, Zane C Neal, Vladimir Subbotin, Guofeng Zhang, Julia Hegge, Stephanie Bertin, Vladimir S Trubetskoy, David B Rozema, David L Lewis, Steven B Kanner
Targeted therapy against VEGF and mTOR pathways has been established as the standard-of-care for metastatic clear cell renal cell carcinoma (ccRCC); however, these treatments frequently fail and most patients become refractory requiring subsequent alternative therapeutic options. Therefore, development of innovative and effective treatments is imperative. About 80%-90% of ccRCC tumors express an inactive mutant form of the von Hippel-Lindau protein (pVHL), an E3 ubiquitin ligase that promotes target protein degradation...
January 2018: Molecular Cancer Therapeutics
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