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Firouzeh Gholampour, Samaneh Keikha
Objectives: Iron is an essential element for living organisms. Iron overload can have detrimental effects on health. This study pertains to the protective role of berberine against ferrous sulfate-induced hepatic and renal functional disorders and histological damages in rats. Materials and Methods: The rats were divided into four groups (n=7): Sham, Ber (10 mg/kg/day for 14 days, by gavage), FS (ferrous sulfate, 30 mg/kg/day for 14 days, intraperitoneally), FS + Ber (ferrous sulfate, 30 mg/kg/day for 14 days; berberine, 10 mg/kg/day for 11 days from fourth day of ferrous sulfate injection)...
May 2018: Iranian Journal of Basic Medical Sciences
Si-Mei He, Yan-Li Liang, Kun Cong, Geng Chen, Xiu Zhao, Qi-Ming Zhao, Jia-Jin Zhang, Xiao Wang, Yang Dong, Jian-Li Yang, Guang-Hui Zhang, Zhi-Long Qian, Wei Fan, Sheng-Chao Yang
The dried rhizomes of Coptis chinensis have been extensively used in heat clearing, dampness drying, fire draining, and detoxification by virtue of their major bioactive components, benzylisoquinoline alkaloids (BIAs). However, C. teeta and C. chinensis are occasionally interchanged, and current understanding of the molecular basis of BIA biosynthesis in these two species is limited. Here, berberine, coptisine, jatrorrhizine, and palmatine were detected in two species, and showed the highest contents in the roots, while epiberberine were found only in C...
2018: Frontiers in Plant Science
Huantian Cui, Yuzi Cai, Li Wang, Beitian Jia, Junchen Li, Shuwu Zhao, Xiaoqian Chu, Jin Lin, Xiaoyu Zhang, Yuhong Bian, Pengwei Zhuang
Berberine (BBR), an alkaloid isolated from Rhizoma Coptidis, Cortex Phellode , and Berberis , has been widely used in the treatment of ulcerative colitis (UC). However, the mechanism of BBR on UC is unknown. In this study, we investigated the activities of T regulatory cell (Treg) and T helper 17 cell (Th17) in a dextran sulfate sodium (DSS)-induced UC mouse model after BBR administration. We also investigated the changes of gut microbiota composition using 16S rRNA analysis. We also examined whether BBR could regulate the Treg/Th17 balance by modifying gut microbiota...
2018: Frontiers in Pharmacology
Yu Chen, Zengming Zheng, Jianle Wang, Chengxuan Tang, Sinan Khor, Jian Chen, Xibang Chen, Zengjie Zhang, Qian Tang, Chenggui Wang, Yiting Lou, Zhouguang Wang, Jian Xiao, Xiangyang Wang
Intervertebral disc degeneration (IVDD) is a chronic disease with complicated pathology involving nucleus pulposus (NP) cell apoptosis and extracellular matrix (ECM) degradation. Previous studies have shown that moderate autophagy has a protective effect against apoptosis in NP cells. Berberine (BBR) is an alkaloid compound with many beneficial properties including antimicrobial, anti-inflammatory, antioxidative, and anti-apoptotic activity. Recently, it was found to induce autophagy in various tissues as well...
2018: International Journal of Biological Sciences
Yonghong Wang, Baofang Wen, Hongli Yu, Dejun Ding, JingJing Zhang, Yunxiang Zhang, Limin Zhao, Weifen Zhang
Nasopharyngeal carcinoma (NPC) is a common epithelial malignancy that occurs in the nasopharynx and it is one of the high incidences of malignant tumors in China. As previous reports, berberine hydrochloride (BH) possesses a repressive effect on the proliferation of various cancer types. But the application of BH was hampered for a long time due to its hydrophobic properties, along with poor stability and bioavailability. In this study, folate acid modified chitosan nanoparticles loaded berberine hydrochloride (BH/FA-CTS NPs) were prepared by the ionic cross-linking technique, the physicochemical properties and the influence of BH/FA-CTS NPs on proliferation, migration and apoptosis in human nasopharyngeal carcinoma CNE-1 cells were studied in vitro and in vivo...
August 1, 2018: Journal of Biomedical Nanotechnology
Xu Yin, Qian Zhang, He-Xin-Ge Zhang, Sha-Na Wuken, Jun-Jun Li, Shun-Gang Jiao, Feng-Qing Yang, Peng-Fei Tu, Xing-Yun Chai
Nine alkaloids and two phenolic glycosides were isolated from EtOH extract of the whole plants of Corydalis hendersonii by various chromatographic techniques including silica gel, ODS, Sephadex LH-20, and semi-preparative HPLC. Their structures were identified as groenlandicine (1), berberine (2), protopine (3), cryptopine (4), N-trans-feruloyloctopamine(5), 3-(4-hydroxy-3-methoxyphenyl)-N-[2-(4-hydroxyphenyl)-2-methoxyethyl] acrylamide (6), N-cis-p-coumaroyloctopamine (7), N-trans-p-coumaroylnoradrenline (8),N-cis-feruloyloctopamine (9), apocynin (10), and glucoacetosyringone (11) by the spectroscopic data analysis and comparison with those in the literature...
May 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Iris E Allijn, Rik Oldenkamp, Gert Storm, Ad M J Ragas, Raymond M Schiffelers
Low amounts of human pharmaceuticals in the aquatic environment can affect bacteria, animals and ultimately humans. Here, the environmental consequences of a shift in prescription behavior from prednisolone to berberine was modeled using an environmental decision support system based on four consecutive steps: emission, fate, exposure and effect. This model estimates the relative aquatic and human health impacts of alternative pharmaceutical prescriptions throughout Europe. Since a Defined Daily Dose (DDD) of berberine has yet to be formulated, the environmental impacts of berberine and prednisolone were compared under the assumption of equal DDDs...
2018: PloS One
Kai Quan, Sichen Li, Dongdong Wang, Yuan Shi, Zixiao Yang, Jianping Song, Yanlong Tian, Yingjun Liu, Zhiyuan Fan, Wei Zhu
Background: Inflammatory cells, such as macrophages, play key roles in the pathogenesis of intracranial aneurysms (IAs). Berberine (BBR), an active component of a Chinese herb Coptis chinensis French , has been shown to have anti-inflammatory properties through suppressing macrophage migration in various inflammation animal model. The goal of this study was to examine BBR's effect on inflammation and IAs formation in a rodent aneurysm model. Methods and Results: Human aneurysm tissues were collected by microsurgical clipping and immunostained for phospho-Focal adhesion kinase (FAK) and CD68+ macrophages...
2018: Frontiers in Pharmacology
Marco Franceschin, Lorenzo Cianni, Massimo Pitorri, Emanuela Micheli, Stefano Cacchione, Claudio Frezza, Mauro Serafini, Ming-Hao Hu, Huafi Su, Zhishu Huang, Lianquan Gu, Armandodoriano Bianco
In this paper, the selective interactions of synthetic derivatives of two natural compounds, berberine and palmatine, with DNA G-quadruplex structures were reported. In particular, the previous works on this subject concerning berberine were further presented and discussed, whereas the results concerning palmatine are presented here for the first time. In detail, these palmatine derivatives were developed by inserting seven different small peptide basic chains, giving several new compounds that have never been reported before...
June 12, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Shuai Li, Uma Gaur, Cheong-Meng Chong, Shaofen Lin, Jiankang Fang, Zhiwen Zeng, Haitao Wang, Wenhua Zheng
Age-related macular degeneration (AMD) is the leading cause of central vision loss in the elderly with less effective treatment, especially for dry AMD (90% of AMD). Although the etiology of this disease is not well elucidated, increasing evidences indicate that excessive reactive oxygen species (ROS) impairing the physiological functions of retinal pigment epithelium (RPE) cells may be one of the main causes. Therefore, it could be a great strategy to find some drugs that can effectively protect RPE cells from oxidative damage which is desired to treat and slow the process of AMD...
June 12, 2018: International Journal of Molecular Sciences
Corinne E Rouquette-Loughlin, Vijaya Dhulipala, Jennifer L Reimche, Erica Raterman, Afrin A Begum, Ann E Jerse, William M Shafer
The gonococcal NorM efflux pump exports substrates with a cationic moiety including quaternary ammonium compounds such as berberine (BE) and ethidium bromide (EB) as well as antibiotics such as ciprofloxacin and solithromycin. The norM gene is part of a four gene operon that is transcribed from a promoter containing a polynucleotide tract of 6 or 7 thymidines (Ts) between the -10 and -35 hexamers; the majority of gonococcal strains analyzed herein contained a T-6 sequence. Primer extension analysis showed that regardless of the length of the poly-T tract, the same transcriptional start site (TSS) was used for expression of norM Interestingly, the T-6 tract correlated with a higher level of both norM expression and gonococcal resistance to NorM substrates BE and EB...
June 11, 2018: Antimicrobial Agents and Chemotherapy
Wanghui Jing, Yasaman Safarpour, Ting Zhang, Pengqi Guo, Guoning Chen, Xiaoming Wu, Qiang Fu, Yitao Wang
Downregulation of P-glycoprotein (P-gp) is implicated in the pathophysiology of inflammatory bowel disease (IBD). Berberine, a principal isoquinoline alkaloid extracted from Berberis species, has been reported to exhibit therapeutic potential in IBD. In this study, we used a dextran sulfate sodium (DSS)-induced colitis rat model to evaluate the effect of berberine on P-gp and explore its mechanism of action. Berberine treatment improved DSS-induced colitis symptoms, attenuated inflammatory markers (myeloperoxidase, tumor necrosis factor-α, and interleukin-1β and -6), and enhanced P-gp expression in a dose-dependent manner...
June 11, 2018: Journal of Pharmacology and Experimental Therapeutics
Zhen Shi, Xiao-Bing Li, Zhi-Cheng Peng, Shou-Peng Fu, Chen-Xu Zhao, Xi-Liang Du, Zhi-Yuan Fang, Zhe Wang, Guo-Wen Liu, Xin-Wei Li
Fatty liver is a major lipid metabolic disease in perinatal dairy cows and is characterized by high blood levels of non-esterified fatty acid (NEFA) and insulin resistance. Berberine (BBR) has been reported to improve insulin sensitivity in mice with hepatic steatosis. Mitochondrial dysfunction is considered a causal factor that induces insulin resistance. This study investigates the underlying mechanism and the beneficial effects of BBR on mitochondrial and insulin signaling in bovine hepatocytes. Revised quantitative insulin sensitivity check index (RQUICKI) of cows with fatty liver was significantly lower than that of healthy cows...
June 6, 2018: International Journal of Molecular Sciences
Che-Yi Lin, Pei-Ling Hsieh, Yi-Wen Liao, Chih-Yu Peng, Ming-Yi Lu, Ching-Hsuan Yang, Cheng-Chia Yu, Chia-Ming Liu
[This corrects the article DOI: 10.18632/oncotarget.20723.].
May 15, 2018: Oncotarget
Long Ma, Zhaoqun Li, Wanna Zhang, Xiaoming Cai, Zongxiu Luo, Yongjun Zhang, Zongmao Chen
The monophagous tea geometrid Ectropis obliqua selectively feed on tea plants, requiring the specialized chemosensory system to forage for certain host. A deep insight into the molecular basis would accelerate the design of insect-behavior-modifying stimuli. In the present study, we focused on the odorant-binding protein 6 (EoblOBP6) with the high abundance in legs transcriptome of E. obliqua moths. qRT-PCR coupled with western blot analyses revealed the dual expression pattern of EoblOBP6 in antennae and legs...
2018: Frontiers in Physiology
Lvhuan Wang, Yumei Zhao, Yanyan Zhang, Tingting Zhang, Jeroen Kool, Govert W Somsen, Qiqin Wang, Zhengjin Jiang
In order to develop a direct and reliable method for discovering lead compounds from traditional Chinese medicines (TCMs), a comparative online ligand fishing platform was developed using immobilized capillary enzyme reactors (ICERs) in combination with liquid chromatography-mass spectrometry (LC-MS). Methacrylate-based monolithic capillaries (400 μm I.D. × 10 cm) containing epoxy reactive groups were used as support to immobilize the target enzyme acetylcholinesterase (AChE). The activity and kinetic parameters of the AChE-ICER were investigated using micro-LC-UV...
May 30, 2018: Journal of Chromatography. A
Zheng Zhao, Qingyan Wei, Weiwei Hua, Yunxin Liu, Xiang Liu, Yubing Zhu
Acetaminophen (APAP) hepatotoxicity remains the leading cause of drug-induced liver injury due to the lack of safe and effective therapeutic agents. Berberine (BBR) is a natural alkaloid derived from traditional medicine Rhizoma Coptidis and possesses various pharmacological properties. The aim of this study was to explore the hepatoprotective effects and underlying mechanisms of BBR on APAP-induced hepatotoxicity. Our results indicated that BBR pretreatment significantly ameliorated APAP-induced hepatic pathological abnormalities and attenuated the elevations of serum aminotransferases and liver/body weight ratio...
July 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Yu Wang, Shulan Zhang
Berberin (BBR), an alkaloid mainly found in Huang Lian (Rhizoma coptidis) and other medicinal herbs, has been reported to exhibit anti-tumor activities against several types of tumor. The biological function of BBR in endometrial cancer (EC) and the underlying molecular mechanisms, however, remain unknown. In this study, BBR was found to inhibit growth, migration, invasion and metastasis of EC cells, both in vitro and in vivo. BBR was also able to suppress tumor through cyclooxygenase-2 (COX-2)/ prostaglandin E2 (PGE2) signaling pathways...
July 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Andrea Poli, Carlo M Barbagallo, Arrigo Cicero, Alberto Corsini, Enzo Manzato, Bruno Trimarco, Franco Bernini, Francesco Visioli, Alfio Bianchi, Giuseppe Canzone, Claudio Crescini, Saula de Kreutzenberg, Nicola Ferrara, Marco Gambacciani, Andrea Ghiselli, Carla Lubrano, Giuseppe Marelli, Walter Marrocco, Vincenzo Montemurro, Damiano Parretti, Roberto Pedretti, Francesco Perticone, Roberto Stella, Franca Marangoni
Current evidence shows that cholesterol management either reduces the likelihood of cardiovascular disease (CVD) or slows down its progression. Hence, it is important that all health professionals make appropriate use of all the available intervention strategies to control risk factors: from dietary improvement and positive lifestyle changes to the use of functional foods, food supplements, and drugs. This review examines the effect of the most frequently occurring cholesterol-lowering substances in functional foods or in supplements across Europe, namely plant sterols and stanols, monacolin K found in red yeast rice, berberine and beta-glucans...
May 30, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Lijun Wang, Xiao Ye, Yanyin Hua, Yingxiang Song
Adipose tissue fibrosis is a novel mechanism for the development of obesity related insulin resistance. Berberine (BBR) has been shown to relieve several metabolic disorders, including obesity and type 2 diabetes. However, the effects of BBR on obesity related adipose fibrosis remain poorly understood. The objective of this study was to assess the effects of BBR on adipose tissue fibrosis in high fat diet (HFD)-induced obese mice. The results showed that BBR reduced animal body weight and significantly improved glucose tolerance in HFD mice...
May 28, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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