keyword
MENU ▼
Read by QxMD icon Read
search

Berberine

keyword
https://www.readbyqxmd.com/read/28208101/berberine-as-a-chemical-and-pharmacokinetic-marker-of-the-butanol-extracted-food-allergy-herbal-formula-2
#1
Nan Yang, Kamal Srivastava, Ying Song, Changda Liu, Sool Cho, Yujuan Chen, Xiu-Min Li
RATIONALE: Food Allergy Herbal Formula 2 (FAHF-2) provided protection against peanut anaphylaxis in a murine model and induced beneficial immune-modulation in humans. Butanol-refined FAHF-2, B-FAHF-2, retained safety and efficacy in the peanut allergic murine model at only 1/5 of FAHF-2 dosage. One compound, berberine, was isolated and identified in vitro as a bioactive component present in FAHF-2 and B-FAHF-2. The aim of this study was to investigate berberine as a chemical and pharmacokinetic marker of B-FAHF-2...
February 13, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28207824/evaluation-of-surgical-anti-adhesion-products-to-reduce-postsurgical-intra-abdominal-adhesion-formation-in-a-rat-model
#2
Long-Xiang Lin, Fang Yuan, Hui-Hui Zhang, Ni-Na Liao, Jing-Wan Luo, Yu-Long Sun
BACKGROUND: Adhesions frequently occur after abdominal surgery. Many anti-adhesion products have been used in clinic. However, the evidences are short for surgeons to reasonably choose the suitable anti-adhesion produces in clinical practice. This study provided such evidence by comparing the efficiency of five products to prevent abdominal adhesion formation in a rat model. METHODS: Fifty-six Sprague-Dawley rats were randomly divided into seven groups: sham-operation group, adhesion group, and five product groups (n = 8)...
2017: PloS One
https://www.readbyqxmd.com/read/28190470/berberine-inhibits-the-proliferation-and-migration-of-breast-cancer-zr-75-30-cells-by-targeting-ephrin-b2
#3
Weina Ma, Man Zhu, Dongdong Zhang, Liu Yang, Tianfeng Yang, Xin Li, Yanmin Zhang
BACKGROUND: Berberine, a plant-derived compound isolated from Coptis chinensis used in traditional Chinese medicine, has been shown to possess anti-cancer properties. However, no study has shown that berberine could target ephrin-B2, which plays a critical role in cell proliferation and migration. PURPOSE: The aim of this study is to investigate the effect of berberine on cancer cell growth and migration, through the regulation of ephrin-B2 and downstream signaling molecules...
February 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28181523/mitochondria-play-an-important-role-in-the-cell-proliferation-suppressing-activity-of-berberine
#4
Xiao-Jin Yan, Xuan Yu, Xin-Pei Wang, Jing-Fei Jiang, Zhi-Yi Yuan, Xi Lu, Fan Lei, Dong-Ming Xing
After being studied for approximately a century, berberine (BBR) has been found to act on various targets and pathways. A great challenge in the pharmacological analysis of BBR at present is to identify which target(s) plays a decisive role. In the study described herein, a rescue experiment was designed to show the important role of mitochondria in BBR activity. A toxic dose of BBR was applied to inhibit cell proliferation and mitochondrial activity, then α-ketobutyrate (AKB), an analogue of pyruvate that serves only as an electron receptor of NADH, was proven to partially restore cell proliferation...
February 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28178753/chemical-composition-differentiation-of-shen-shuai-ning-granule-between-combined-decoction-and-separated-decoction-using-hplc-dad-esi-qtof-ms
#5
Jianli Liu, Yu Zhang, Yimeng Hao, Ying Zhao, Yanjiao Li, Rulan Qin, Chongning Lv, Jincai Lu
Shen-Shuai-Ning (SSN) granule, a traditional Chinese medicine formula is widely used in clinical practice for treating chronic renal failure. However, detailed chemical profile about it was unknown. Here, HPLC-ESI-QTOF-MS was employed for the systematic chemical analysis of SSN. A total of 52 compounds were identified and the characteristic ions of compounds were described. Furthermore, chemical consistency between combined decoction and separated decoction of SSN was evaluated using HPLC-DAD. The chemical comparison between two preparations of SSN granule (combined decoction and separated decoction of Coptides Rhizoma) indicated a significant difference in content of many compounds including Salvianolic acid A, Salvianolic acid B, Berberine, Palmatine and Epiberberine...
February 8, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28167234/epiberberine-a-natural-protoberberine-alkaloid-inhibits-urease-of-helicobacter-pylori-and-jack-bean-susceptibility-and-mechanism
#6
Lihua Tan, Cailan Li, Hanbin Chen, Zhizhun Mo, Jiangtao Zhou, Yuhong Liu, Zhilin Ma, Yuyao Xu, Xiaobo Yang, Jianhui Xie, Ziren Su
In our previous study, Rhizoma Coptidis extract was found to exert more potent inhibitory effect than its major component berberine towards urease from Helicobacter pylori (HPU) and jack bean (JBU). In continuation of our work, the present study was designed to further comparatively investigate the urease inhibitory activities of five major protoberberine alkaloids in Rhizoma Coptidis, namely berberine, palmatine, coptisine, epiberberine, jateorhizine to identify the bioactive constituent, and illuminate the potential mechanism of action...
February 3, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28157699/berberine-induced-autophagic-cell-death-by-elevating-grp78-levels-in-cancer-cells
#7
Xiaoqin La, Lichao Zhang, Zhuoyu Li, Peng Yang, Yingying Wang
Berberine, an isoquinoline alkaloid extracted from Coptidis Rhizoma, has been shown to induce cancer cell autophagic death. Glucose regulated protein 78 (GRP78) is associated with stress-induced autophagy. However, the related mechanisms between berberine-induced cancer cell autophagy and GRP78 remain to be elucidated. Here, we report that berberine can induce autophagic cancer cell death by elevating levels of GRP78. These results further demonstrated that berberine enhanced GRP78 by suppression of ubiquitination / proteasomal degradation of GRP78 and activation of ATF6...
February 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28154180/berberine-induced-inactivation-of-signal-transducer-and-activator-of-transcription-5-signaling-promotes-male-specific-expression-of-a-bile-acid-uptake-transporter
#8
Pengli Bu, Yuan Le, Yue Zhang, Youcai Zhang, Xingguo Cheng
Sodium-taurocholate co-transporting polypeptide (Ntcp/NTCP) is the major uptake transporter of bile salts in mouse and human livers. In certain diseases, including endotoxemia, cholestasis, diabetes, and hepatocarcinoma, Ntcp/NTCP expression is markedly reduced, which interferes with enterohepatic circulation of bile salts, impairing the absorption of lipophilic compounds. Therefore, normal Ntcp/NTCP expression in the liver is physiologically important. Berberine is an herbal medicine used historically to improve liver function and has recently been shown to repress signal transducer and activator of transcription (Stat) signaling...
February 1, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28146096/pharmacokinetics-studies-of-12-alkaloids-in-rat-plasma-after-oral-administration-of-zuojin-and-fan-zuojin-formulas
#9
Ping Qian, You-Bo Zhang, Yan-Fang Yang, Wei Xu, Xiu-Wei Yang
Zuojin formula (ZJ) is a traditional Chinese medicine (TCM) prescription consisted of Coptidis Rhizoma (CR) and Euodiae Fructus (EF), and has been used to treat gastrointestinal (GI) disease for more than 700 years. Fan-Zuojin formula (FZJ) is a related TCM prescription also consisted of CR and EF with the opposite proportion. In recent years, ZJ was getting more attention for its antitumor potential, but the indeterminate pharmacokinetic (PK) behavior restricted its clinical applications, and the PK differences between ZJ and FZJ were also largely unknown...
January 30, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28144822/in-vitro-activity-of-berberine-alone-and-in-combination-with-antifungal-drugs-against-planktonic-forms-and-biofilms-of-trichosporon-asahii
#10
Lin Cong, Yong Liao, Suteng Yang, Rongya Yang
Trichosporon asahii (T. asahii) is an opportunistic pathogen that can cause life-threatening infections in immunocompromised patients, with high mortality rates up to 80% despite treated with antifungal drugs. The biofilms-forming ability of T. asahii on indwelling medical devices may account for the resistance to antifungal drugs. Berberine (BBR) has been demonstrated to have antifungal activity and synergistic effects in combination with antifungal drugs against pathogenic fungi. In the present study, the in vitro activities of BBR alone or combined with fluconazole (FLC), itraconazole (ITC), voriconazole (VRC), caspofungin (CAS) and amphotericin B (AMB) against planktonic forms and biofilms of 21 clinical T...
January 31, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28133369/functional-foods-and-dietary-supplements-for-the-management-of-dyslipidaemia
#11
REVIEW
Paola M Hunter, Robert A Hegele
Dyslipidaemia is characterized by increased blood levels of total or LDL cholesterol and triglycerides, or decreased HDL cholesterol levels, and is a risk factor for cardiovascular disease. Dyslipidaemia has a high worldwide prevalence, and many patients are turning to alternatives to pharmacotherapy to manage their lipid levels. Lifestyle modification should be emphasized in all patients to reduce cardiovascular risk and can be initiated before pharmacotherapy in primary prevention of cardiovascular disease...
January 30, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28123715/antiproliferative-effect-of-berberine-on-canine-mammary-gland-cancer-cell-culture
#12
Reyhaneh Sefidabi, Pejman Mortazavi, Saeed Hosseini
Canine mammary gland tumors are the most frequent cause of cancer in female dogs. Numerous studies using cancer cell lines and clinical trials have indicated that various natural products and antioxidants reduce or possibly prevent the development of cancer. Berberine (BBR), the most important alkaloid in the Berberidaceae, which exerts a wide range of pharmacological and biochemical effects, has drawn much attention due to its particularly high antitumor activity in vitro and in animal studies. The aim of the present study was to investigate the antiproliferative effect of BBR against a canine mammary gland carcinoma cell line (CF41...
January 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28106326/new-oil-in-salt-liquid-phase-microextraction-on-permutite-for-the-extraction-and-concentration-of-alkaloids-in-coptis-chinensis
#13
Ping Gao, Xuan Chen, Shuang Hu, Xiaohong Bai, Miaomiao Luo
A novel oil-in-salt liquid-phase microextraction was developed and introduced for the extraction and concentration of the trace levels of active alkaloids in Coptis chinensis prior to being analyzed by high-performance liquid chromatography with ultraviolet detection. Also, the oil-in-salt extraction mechanism was analyzed, the enrichment factor and extraction recovery were redefined, and the proposed method was compared with other methods. In the approach, the mixed solvent of pentanol/octanol (6:4, v/v) and NaCl (20% w/v) are immobilized on the permutite surface in turn to form oil-in-salt double membranes, through which the target analytes can be molecularized though salting-out effect and be extracted by organic solvent...
January 20, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28102849/berberine-sonodynamic-therapy-induces-autophagy-and-lipid-unloading-in-macrophage
#14
Jiayuan Y Kou, Ying Li, Zhaoyu Y Zhong, Yueqing Q Jiang, Xuesong S Li, Xiaobo B Han, Zhongni N Liu, Ye Tian, Liming M Yang
Impaired autophagy in macrophages accompanies the progression of atherosclerosis and contributes to lipid loading in plaques and ineffective lipid degradation. Therefore, evoking autophagy and its associated cholesterol efflux may provide a therapeutic treatment for atherosclerosis. In the present study, berberine-mediated sonodynamic therapy (BBR-SDT) was used to induce autophagy and cholesterol efflux in THP-1 macrophages and derived foam cells. Following BBR-SDT, autophagy was increased in the macrophages, autophagy resistance in the foam cells was prevented, and cholesterol efflux was induced...
January 19, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28101183/protective-effect-of-berberine-against-oxidative-stress-induced-apoptosis-in-rat-bone-marrow-derived-mesenchymal-stem-cells
#15
Wangyang Li, Yamei Liu, Bin Wang, Yiwen Luo, Nianhong Hu, Dongfeng Chen, Xunchao Zhang, Yunpu Xiong
Bone marrow-derived mesenchymal stem cells (BMSCs) have the potential to be used for the treatment of delayed union, nonunion or persistent bone defects in MSC-based cell therapy. However, implantation of BMSCs into the fracture site is confronted with apoptosis on account of harsh conditions and oxidative stress. In the present study, the anti-apoptotic effects of berberine (BBR) on BMSCs subjected to hydrogen peroxide (H2O2) are investigated, and the potential underlying mechanisms are explored. Oxidative injury was induced by exposure to H2O2, and cell viability was assessed using a cell counting kit-8 assay...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28098901/effect-of-evodiamine-and-berberine-on-the-interaction-between-dnmts-and-target-micrornas-during-malignant-transformation-of-the-colon-by-tgf-%C3%AE-1
#16
Chao Huang, Hong Liu, Xiu-Li Gong, Li-Yun Wu, Bin Wen
The tissue microenvironment functions as a crucial player in carcinogenesis, and transforming growth factor-β1 (TGF-β1) within the microenvironment stimulates the formation of neoplasms. Using an in vitro model of malignancy induced by TGF-β1, we assessed the effect of evodiamine and berberine on the interaction between DNA methyltransferases (DNMTs) and target microRNAs (miRNAs) in the model. Colon tissues from neonatal rats 7 days of age were cultured and malignancy was induced by TGF-β1 in vitro for 48 h, and then the tissues were respectively treated with evodiamine and berberine for 24 h...
January 17, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28096426/correction-to-berberine-reverses-epithelial-to-mesenchymal-transition-and-inhibits-metastasis-and-tumor-induced-angiogenesis-in-human-cervical-cancer-cells
#17
(no author information available yet)
No abstract text is available yet for this article.
February 2017: Molecular Pharmacology
https://www.readbyqxmd.com/read/28092858/the-synthesis-and-antistaphylococcal-activity-of-9-13-disubstituted-berberine-derivatives
#18
Jing Wang, Teng Yang, Huang Chen, Yun-Nan Xu, Li-Fang Yu, Ting Liu, Jie Tang, Zhengfang Yi, Cai-Guang Yang, Wei Xue, Fan Yang
A series of novel 9, 13-disubstituted berberine derivatives have been synthesized and evaluated for the antibacterial activities against Staphylococcus aureus, including Newman strain and multidrug-resistant strains (NRS-1, NRS-70, NRS-100, NRS-108, and NRS-271). Compound 20 shows the most potent activity against the growth of Newman strain, with a MIC value of 0.78 μg/mL, which is comparable with the positive control vancomycin. In addition, compound 20, 21, and 33 are highly antistaphylococcal active against five strains of multidrug-resistant S...
January 9, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28090273/the-effects-of-berberine-and-palmatine-on-efflux-pumps-inhibition-with-different-gene-patterns-in-pseudomonas-aeruginosa-isolated-from-burn-infections
#19
Seyed Sajjad Aghayan, Hamidreza Kalalian Mogadam, Mozhgan Fazli, Davood Darban-Sarokhalil, Seyed Sajjad Khoramrooz, Fereshteh Jabalameli, Somayeh Yaslianifard, Mehdi Mirzaii
BACKGROUND: Related Multidrug Resistance (MDR) to efflux pumps is a significant problem in treating infections caused by Pseudomonas aeruginosa (P. aeruginosa). Plant compounds have been identified as Pump Inhibitors (EPIs). In the current study, the potential effect of Berberine and Palmatine as EPIs were investigated on efflux pump inhibition through focusing on different gene patterns in P. aeruginosa isolated from burn infections. METHODS: All isolates were collected and identified using the standard biochemical tests...
January 2017: Avicenna Journal of Medical Biotechnology
https://www.readbyqxmd.com/read/28088519/phytochemicals-as-multi-target-inhibitors-of-the-inflammatory-pathway-a-modeling-and-experimental-study
#20
Nisha S Devi, Meera Ramanan, Padmapriya Paragi-Vedanthi, Mukesh Doble
The arachidonic acid pathway consists of several enzymes and targeting them is favored for developing anti-inflammatory drugs. However, till date the current drugs are generally active against a single target, leading to undesirable side-effects. Phytochemicals are known to inhibit multiple targets simultaneously and hence, an attempt is made here to investigate their suitability. A pharmacophore based study is performed with three sets of reported phytochemicals namely, dual 5-LOX/mPGES1, alkaloids and FLAP inhibitors...
January 11, 2017: Biochemical and Biophysical Research Communications
keyword
keyword
5949
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"