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https://www.readbyqxmd.com/read/28651007/urban-chikungunya-in-the-middle-east-and-north-africa-a-systematic-review
#1
John M Humphrey, Natalie B Cleton, Chantal B E M Reusken, Marshall J Glesby, Marion P G Koopmans, Laith J Abu-Raddad
BACKGROUND: The epidemiology of Chikungunya virus (CHIKV) in the Middle East and North Africa (MENA) is not well characterized despite increasing recognition of its expanding infection and disease burden in recent years. METHODOLOGY / PRINCIPAL FINDINGS: Following Cochrane Collaboration guidelines and reporting our findings following PRISMA guidelines, we systematically reviewed records describing the human prevalence and incidence, CHIKV prevalence/infection rates in vectors, outbreaks, and reported cases for CHIKV across the MENA region...
June 26, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28650987/accuracy-of-zika-virus-disease-case-definition-during-simultaneous-dengue-and-chikungunya-epidemics
#2
José Ueleres Braga, Clarisse Bressan, Ana Paula Razal Dalvi, Guilherme Amaral Calvet, Regina Paiva Daumas, Nadia Rodrigues, Mayumi Wakimoto, Rita Maria Ribeiro Nogueira, Karin Nielsen-Saines, Carlos Brito, Ana Maria Bispo de Filippis, Patrícia Brasil
BACKGROUND: Zika is a new disease in the American continent and its surveillance is of utmost importance, especially because of its ability to cause neurological manifestations as Guillain-Barré syndrome and serious congenital malformations through vertical transmission. The detection of suspected cases by the surveillance system depends on the case definition adopted. As the laboratory diagnosis of Zika infection still relies on the use of expensive and complex molecular techniques with low sensitivity due to a narrow window of detection, most suspected cases are not confirmed by laboratory tests, mainly reserved for pregnant women and newborns...
2017: PloS One
https://www.readbyqxmd.com/read/28650959/peridomestic-aedes-malayensis-and-aedes-albopictus-are-capable-vectors-of-arboviruses-in-cities
#3
Ian H Mendenhall, Menchie Manuel, Mahesh Moorthy, Theodore T M Lee, Dolyce H W Low, Dorothée Missé, Duane J Gubler, Brett R Ellis, Eng Eong Ooi, Julien Pompon
BACKGROUND: Dengue and chikungunya are global re-emerging mosquito-borne diseases. In Singapore, sustained vector control coupled with household improvements reduced domestic mosquito populations for the past 45 years, particularly the primary vector Aedes aegypti. However, while disease incidence was low for the first 30 years following vector control implementation, outbreaks have re-emerged in the past 15 years. Epidemiological observations point to the importance of peridomestic infection in areas not targeted by control programs...
June 26, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28650420/first-detection-of-chikungunya-virus-in-breast-milk
#4
Gubio Soares Campos, Antonio Carlos Albuquerque Bandeira, Verônica França Diniz Rocha, Juarez Pereira Dias, Rejane Hughes Carvalho, Silvia Ines Sardi
Chikungunya virus (CHIKV) has never been detected in human breast milk. This is a brief report of CHIKV infection in a breastfeeding woman of a 3 month old baby. The mother´s CHIKV-RT PCR was positive in serum, urine and milk. The baby´s CHIKV serology and RT-PCR were negative. The detection of CHIKV in milk raises clinical and epidemiologic questions.
June 22, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28648861/preparing-clinicians-for-re-emerging-arbovirus-infectious-diseases-in-europe
#5
REVIEW
Louise Sigfrid, Chantal Reusken, Isabella Eckerle, Veronique Nussenblatt, Sam Lipworth, Janey Messina, Moritz Kraemer, Onder Ergonul, Anna Papa, Marion Koopmans, Peter Horby
BACKGROUND: Arthropod-borne virus (Arbovirus) infections are considered an emerging threat for Europe, with an increase in cases in recent decades. The increase in global travel and trade has contributed to the introduction of vectors and viruses into new geographical areas. Tropical arboviruses such as dengue and chikungunya have re-emerged causing local, sporadic outbreaks ignited by travel-imported cases. The recent Zika virus outbreak in the Americas highlighted a need to strengthen preparedness to (re-)emerging arbovirus infections globally...
June 22, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28647172/infection-related-microcephaly-after-the-2015-and-2016-zika-virus-outbreaks-in-brazil-a-surveillance-based-analysis
#6
Wanderson Kleber de Oliveira, Giovanny Vinícius Araújo de França, Eduardo Hage Carmo, Bruce Bartholow Duncan, Ricardo de Souza Kuchenbecker, Maria Inês Schmidt
BACKGROUND: On Nov 11, 2015, the Brazilian Ministry of Health declared a Public Health Emergency of National Concern in response to an increased number of microcephaly cases, possibly related to previous Zika virus outbreaks. We describe the course of the dual epidemics of the Zika virus infection during pregnancy and microcephaly in Brazil up to Nov 12, 2016, the first anniversary of this declaration. METHODS: We used secondary data for Zika virus and microcephaly cases obtained through the Brazilian Ministry of Health's surveillance systems from Jan 1, 2015, to Nov 12, 2016...
June 21, 2017: Lancet
https://www.readbyqxmd.com/read/28646879/discovery-of-a-single-male-aedes-aegypti-l-in-merseyside-england
#7
Thom Dallimore, Tony Hunter, Jolyon M Medlock, Alexander G C Vaux, Ralph E Harbach, Clare Strode
BACKGROUND: The mosquito Aedes aegypti (L.) is found in tropical and sub-tropical regions where it is the major vector of dengue fever, yellow fever, chikungunya and more recently Zika virus. Given its importance as a vector of arboviruses and its propensity to be transported to new regions, the European Centre for Disease Prevention and Control (ECDC) has placed Ae. aegypti on a list of potentially invasive mosquito species. It was previously reported in the United Kingdom (UK) in 1865 and 1919 but did not establish on either occasion...
June 24, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28644900/suppression-of-chikungunya-virus-replication-and-differential-innate-responses-of-human-peripheral-blood-mononuclear-cells-during-co-infection-with-dengue-virus
#8
Mariana Ruiz Silva, José A Aguilar Briseño, Vinit Upasani, Heidi van der Ende-Metselaar, Jolanda M Smit, Izabela A Rodenhuis-Zybert
Dengue and chikungunya are viral diseases transmitted to humans by infected Aedes spp. mosquitoes. With an estimated 390 million infected people per year dengue virus (DENV) currently causes the most prevalent arboviral disease. During the last decade chikungunya virus (CHIKV) has caused large outbreaks and has expanded its territory causing millions of cases in Asia, Africa and America. The viruses share a common mosquito vector and during the acute phase cause similar flu-like symptoms that can proceed to more severe or debilitating symptoms...
June 23, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28638845/detection-of-the-northeastern-african-rift-valley-fever-virus-lineage-during-the-2015-outbreak-in-mauritania
#9
Ndeye Sakha Bob, Hampâté Bâ, Gamou Fall, Elkhalil Ishagh, Mamadou Y Diallo, Abdourahmane Sow, Pape Mbacké Sembene, Ousmane Faye, Brahim El Kouri, Mohamed Lemine Sidi, Amadou Alpha Sall
BACKGROUND: Rift Valley fever (RVF) is an acute viral anthropozoonosis that causes epizootics and epidemics among livestock population and humans. Multiple emergences and reemergences of the virus have occurred in Mauritania over the last decade. This article describes the outbreak that occurred in 2015 in Mauritania and reports the results of serological and molecular investigations of blood samples collected from suspected RVF patients. METHODS: An RVF outbreak was reported from 14 September to 26 November 2015 in Mauritania...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28637387/immunopathology-of-chikungunya-virus-infection-lessons-learned-from-patients-and-animal-models
#10
Lisa F P Ng
Chikungunya virus (CHIKV) is an arthropod-borne alphavirus that causes acute and chronic arthritis. The virus reemerged in the Indian Ocean islands in 2005-2006 and is responsible for outbreaks in the Caribbean islands and the Americas since late 2013. Despite the wealth of research over the past 10 years, there are no commercially available antiviral drugs or vaccines. Treatment usually involves analgesics, anti-inflammatory drugs, and supportive care. Most studies have been focused on understanding the pathogenesis of CHIKV infection through clinical observation and with animal models...
June 21, 2017: Annual Review of Virology
https://www.readbyqxmd.com/read/28633900/analytical-and-clinical-performance-of-a-chikungunya-qrt-pcr-for-central-and-south-america
#11
Thomas Edwards, Leticia Del Carmen Castillo Signor, Christopher Williams, Clément Larcher, Mauricio Espinel, Jane Theaker, Evelin Donis, Luis E Cuevas, Emily R Adams
Chikungunya was introduced into the Americas in 2015 causing a pandemic across the continent. Testing during the acute phase of infection relies on qRT-PCR, but available assays have a number of limitations. A qRT-PCR assay specific to the chikungunya E1 gene was designed using sequence data from contemporary strains. A probit analysis established the 95% limit of detection as 19.6 copies per reaction. We compared the assay with a US Centers for Disease Control (CDC) chikungunya qRT-PCR as the reference standard...
June 8, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28633891/aids-avian-flu-sars-mers-ebola-zika%C3%A2-what-next
#12
REVIEW
Leslie A Reperant, Albert D M E Osterhaus
Emerging infections have threatened humanity since times immemorial. The dramatic anthropogenic, behavioral and social changes that have affected humanity and the environment in the past century have accelerated the intrusion of novel pathogens into the global human population, sometimes with devastating consequences. The AIDS and influenza pandemics have claimed and will continue to claim millions of lives. The recent SARS and Ebola epidemics have threatened populations across borders. The emergence of MERS may well be warning signals of a nascent pandemic threat, while the potential for geographical spread of vector-borne diseases, such as Zika, but also Dengue and Chikungunya is unprecedented...
June 17, 2017: Vaccine
https://www.readbyqxmd.com/read/28630444/modelling-the-effects-of-global-climate-change-on-chikungunya-transmission-in-the-21-st-century
#13
Nils B Tjaden, Jonathan E Suk, Dominik Fischer, Stephanie M Thomas, Carl Beierkuhnlein, Jan C Semenza
The arrival and rapid spread of the mosquito-borne viral disease Chikungunya across the Americas is one of the most significant public health developments of recent years, preceding and mirroring the subsequent spread of Zika. Globalization in trade and travel can lead to the importation of these viruses, but climatic conditions strongly affect the efficiency of transmission in local settings. In order to direct preparedness for future outbreaks, it is necessary to anticipate global regions that could become suitable for Chikungunya transmission...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28628616/therapeutic-administration-of-a-recombinant-human-monoclonal-antibody-reduces-the-severity-of-chikungunya-virus-disease-in-rhesus-macaques
#14
Rebecca Broeckel, Julie M Fox, Nicole Haese, Craig N Kreklywich, Soila Sukulpovi-Petty, Alfred Legasse, Patricia P Smith, Michael Denton, Carsten Corvey, Shiv Krishnan, Lois M A Colgin, Rebecca M Ducore, Anne D Lewis, Michael K Axthelm, Marie Mandron, Pierre Cortez, Jonathan Rothblatt, Ercole Rao, Ingo Focken, Kara Carter, Gopal Sapparapau, James E Crowe, Michael S Diamond, Daniel N Streblow
Chikungunya virus (CHIKV) is a mosquito-borne virus that causes a febrile syndrome in humans associated with acute and chronic debilitating joint and muscle pain. Currently no licensed vaccines or therapeutics are available to prevent or treat CHIKV infections. We recently isolated a panel of potently neutralizing human monoclonal antibodies (mAbs), one (4N12) of which exhibited prophylactic and post-exposure therapeutic activity against CHIKV in immunocompromised mice. Here, we describe the development of an engineered CHIKV mAb, designated SVIR001, that has similar antigen binding and neutralization profiles to its parent, 4N12...
June 19, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28627853/determinants-of-outbreaks-of-emerging-infectious-diseases-the-case-of-chikungunya-in-indian-ocean-2004-2007
#15
Antoine Flahault
Emerging outbreaks of arboviroses are most often tied to the convergence of a set of factors which have physical and environmental, genetic and biological, ecological, social, political and economic origins. Thirteen out of these factors are known as main determinants of emerging infectious disease outbreaks. This paper assesses the role of these factors from exploring the Chikungunya outbreak which occurred in Indian Ocean in 2004-2007, as case study. Chikungunya is an alphavirus borne and transmitted by Aedes aegypti and Aedes albopictus...
May 3, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28626536/school-based-health-education-in-yucatan-mexico-about-the-chikungunya-virus-and-mosquito-illness-prevention
#16
Monica Seungah Choo, R Alexander Blackwood
The Chikungunya virus (CHIKV) has been rapidly spreading throughout Latin America, utilizing pre-existing vectors to infiltrate the immunologically naïve populations. With the current rise of the Zika Virus, there is an urgent need for more rigorous vector control efforts to prevent further Zika breakout. We designed a school-based education module on CHIKV and mosquito prevention and presented it to the local students of ages of 6-18 in a rural town called Sudzal in Yucatan, Mexico. We distributed questionnaires before and after education to test the students' knowledge of CHIKV and mosquito prevention...
May 31, 2017: Infectious Disease Reports
https://www.readbyqxmd.com/read/28619679/antiviral-activity-of-1-2-3-triazolo-4-5-d-pyrimidin-7-6h-ones-against-chikungunya-virus-targeting-the-viral-capping-nsp1
#17
Alba Gigante, Asier Gómez-SanJuan, Leen Delang, C Li, Oskía Bueno, Ana María Gamo, Eva-María Priego, María-José Camarasa, Dirk Jochmans, Pieter Leyssen, Etienne Decroly, Bruno Coutard, Gilles Querat, Johan Neyts, María-Jesús Pérez-Pérez
Chikungunya virus (CHIKV) is a re-emerging alphavirus transmitted to humans by Aedes mosquitoes. Since 2005, CHIKV has been spreading worldwide resulting in epidemics in Africa, the Indian Ocean islands, Asia and more recently in the Americas. CHIKV is thus considered as a global health concern. There is no specific vaccine or drug available for the treatment of this incapacitating viral infection. We previously identified 3-aryl-[1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones as selective inhibitors of CHIKV replication and proposed the viral capping enzyme nsP1 as a target...
June 12, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28617853/co-occurrence-of-viruses-and-mosquitoes-at-the-vectors-optimal-climate-range-an-underestimated-risk-to-temperate-regions
#18
Marcus S C Blagrove, Cyril Caminade, Elisabeth Waldmann, Elizabeth R Sutton, Maya Wardeh, Matthew Baylis
Mosquito-borne viruses have been estimated to cause over 100 million cases of human disease annually. Many methodologies have been developed to help identify areas most at risk from transmission of these viruses. However, generally, these methodologies focus predominantly on the effects of climate on either the vectors or the pathogens they spread, and do not consider the dynamic interaction between the optimal conditions for both vector and virus. Here, we use a new approach that considers the complex interplay between the optimal temperature for virus transmission, and the optimal climate for the mosquito vectors...
June 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28614481/persistent-arthralgia-and-related-risks-factors-in-laboratory-confirmed-cases-of-chikungunya-virus-infection-in-mexico
#19
Efrén Murillo-Zamora, Oliver Mendoza-Cano, Benjamín Trujillo-Hernández, Ramón Alberto Sánchez-Piña, José Guzmán-Esquivel
Objective: To estimate the cumulative incidence of persistent arthralgia at 6 months from acute Chikungunya virus (CHIKV) infection and to evaluate the association of clinical markers with the risk of long-term arthralgia. Methods: This multicenter retrospective cohort study was conducted in the Mexican state of Colima. A total of 136 individuals aged 15 years and older with serologically confirmed CHIKV infection were enrolled. Participants were interviewed at 6 months from the onset of symptoms, and self-reported persistent arthralgia (PA) was the main binary outcome...
June 8, 2017: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28614394/first-report-of-naturally-infected-aedes-aegypti-with-chikungunya-virus-genotype-ecsa-in-the-americas
#20
André Luis Costa-da-Silva, Rafaella Sayuri Ioshino, Vivian Petersen, Antonio Fernando Lima, Marielton Dos Passos Cunha, Michael R Wiley, Jason T Ladner, Karla Prieto, Gustavo Palacios, Danuza Duarte Costa, Lincoln Suesdek, Paolo Marinho de Andrade Zanotto, Margareth Lara Capurro
BACKGROUND: The worldwide expansion of new emergent arboviruses such as Chikungunya and Zika reinforces the importance in understanding the role of mosquito species in spreading these pathogens in affected regions. This knowledge is essential for developing effective programs based on species specificity to avoid the establishment of endemic transmission cycles sustained by the identified local vectors. Although the first autochthonous transmission of Chikungunya virus was described in 2014 in the north of Brazil, the main outbreaks were reported in 2015 and 2016 in the northeast of Brazil...
June 2017: PLoS Neglected Tropical Diseases
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