keyword
https://read.qxmd.com/read/38536999/occurrence-of-arbovirus-infections-in-two-riverine-populations-in-the-municipality-of-humait%C3%A3-amazonas-brazil
#1
JOURNAL ARTICLE
Jaqueline Carvalho de Oliveira Silva, Igor Rodrigo Ferreira Siqueira, Leormando Fortunato Dornelas, Cristhian Magalhães Ribeiro, João Pedro Berno Gomes, Iagor Wingenbah Guadagnin, Antonieta Relvas Pereira, Genimar Rebouças Julião, Juliana de Souza Almeida Aranha Camargo, Sergio Almeida Basano, Luís Marcelo Aranha Camargo
BACKGROUND: The riverine communities of the Amazon comprise different social groups that inhabit the rural areas on the banks of rivers and lakes. Residents usually travel by river to rural and urban areas and are then exposed to urbanized diseases such as those caused by arbovirus infection. In Brazil, emerging diseases such as dengue, Zika, chikungunya, and those caused by infection with Oropouche and Mayaro viruses necessitate epidemiological surveillance. This study was aimed at determining the frequency of positivity for immunoglobulin (Ig)G and IgM antibodies against Zika, chikungunya, and dengue viruses and performing molecular analyses to detect viral RNA for the Zika, chikungunya, dengue virus, Oropouche, and Mayaro viruses, in the same serum samples obtained from riverside populations...
2024: Revista da Sociedade Brasileira de Medicina Tropical
https://read.qxmd.com/read/38535541/lower-limb-paralysis-associated-with-chikungunya-in-kinshasa-the-democratic-republic-of-the-congo-survey-report
#2
JOURNAL ARTICLE
Mathy Matungala-Pafubel, Junior Bulabula-Penge, Meris Matondo-Kuamfumu, Samy Esala, François Edidi-Atani, Elisabeth Pukuta-Simbu, Paul Tshiminyi-Munkamba, Yannick Tutu Tshia N'kasar, Trésor Katanga, Etienne Ndomba-Mukanya, Delphine Mbonga-Mande, Lionel Baketana-Kinzonzi, Eddy Kinganda-Lusamaki, Daniel Mukadi-Bamuleka, Fabrice Mambu-Mbika, Placide Mbala-Kingebeni, Edith Nkwembe-Ngabana, Antoine Nkuba-Ndaye, Daniel Okitundu-Luwa, Steve Ahuka-Mundeke
Polio-associated paralysis is one of the diseases under national surveillance in the Democratic Republic of the Congo (DRC). Although it has become relatively rare due to control measures, non-polio paralysis cases are still reported and constitute a real problem, especially for etiological diagnosis, which is necessary for better management and response. From September 2022 to April 2023, we investigated acute flaccid paralysis (AFP) cases in Kinshasa following an alert from the Provincial Division of Health...
February 23, 2024: Pathogens
https://read.qxmd.com/read/38535401/-wolbachia-infection-through-hybridization-to-enhance-an-incompatible-insect-technique-based-suppression-of-aedes-albopictus-in-eastern-spain
#3
JOURNAL ARTICLE
Maria Cholvi, María Trelis, Rubén Bueno-Marí, Messaoud Khoubbane, Rosario Gil, Antonio Marcilla, Riccardo Moretti
The emergence of insecticide resistance in arbovirus vectors is putting the focus on the development of new strategies for control. In this regard, the exploitation of Wolbachia endosymbionts is receiving increasing attention due to its demonstrated effectiveness in reducing the vectorial capacity of Aedes mosquitoes. Here, we describe the establishment of a naïve Wolbachia infection in a wild Aedes albopictus population of eastern Spain through a hybridization approach to obtain males capable of sterilizing wild females...
March 20, 2024: Insects
https://read.qxmd.com/read/38534750/development-of-multiplex-molecular-assays-for-simultaneous-detection-of-dengue-serotypes-and-chikungunya-virus-for-arbovirus-surveillance
#4
JOURNAL ARTICLE
Louis Robert W Belem, Sylvester Agha Ibemgbo, Michel Kiréopori Gomgnimbou, Dileep Kumar Verma, Antoinette Kaboré, Ankit Kumar, Ibrahim Sangaré, Sujatha Sunil
The major arboviruses mainly belong to the Bunyaviridae , Togaviridae , and Flaviviridae families, among which the chikungunya virus and dengue virus have emerged as global public health problems. The main objective of this study was to develop specific, sensitive, and cost-effective molecular multiplex RT-PCR and RT-qPCR assays for the rapid and simultaneous detection of CHIKV and the four serotypes of DENV for arbovirus surveillance. Specific primers for all viruses were designed, and one-step multiplex RT-PCR (mRT-PCR) and RT-qPCR (mRT-qPCR) were developed using reference strains of the CHIKV and DENV serotypes...
March 6, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38529912/central-nervous-system-infections-in-the-tropics
#5
JOURNAL ARTICLE
Angel Miraclin T, Bhagteshwar Singh, Priscilla Rupali
PURPOSE OF REVIEW: Emerging and re-emerging central nervous system (CNS) infections are a major public health concern in the tropics. The reasons for this are myriad; climate change, rainfall, deforestation, increased vector density combined with poverty, poor sanitation and hygiene. This review focuses on pathogens, which have emerged and re-emerged, with the potential for significant morbidity and mortality. RECENT FINDINGS: In recent years, multiple acute encephalitis outbreaks have been caused Nipah, which carries a high case fatality...
March 27, 2024: Current Opinion in Infectious Diseases
https://read.qxmd.com/read/38529314/irritant-and-repellent-behaviors-of-sterile-male-aedes-aegypti-l-diptera-culicidae-mosquitoes-are-crucial-in-the-development-of-disease-control-strategies-applying-sterile-insect-technique
#6
JOURNAL ARTICLE
Wasana Boonyuan, Amonrat Panthawong, Thodsapon Thannarin, Titima Kongratarporn, Vararas Khamvarn, Theeraphap Chareonviriyaphap, Jirod Nararak
The mosquito Aedes aegypti , known to transmit important arboviral diseases, including dengue, chikungunya, Zika and yellow fever. Given the importance of this disease vector, a number of control programs have been proposed involving the use of the sterile insect technique (SIT). However, the success of this technique hinges on having a good understanding of the biology and behavior of the male mosquito. Behavioral responses of Ae. aegypti male populations developed for SIT technology were tested under laboratory conditions against chemical and natural irritants and repellents using an excito-repellency (ER) chamber...
2024: PeerJ
https://read.qxmd.com/read/38528146/phosphatidylserine-exposing-extracellular-vesicles-in-body-fluids-are-an-innate-defence-against-apoptotic-mimicry-viral-pathogens
#7
JOURNAL ARTICLE
Rüdiger Groß, Hanna Reßin, Pascal von Maltitz, Dan Albers, Laura Schneider, Hanna Bley, Markus Hoffmann, Mirko Cortese, Dhanu Gupta, Miriam Deniz, Jae-Yeon Choi, Jenny Jansen, Christian Preußer, Kai Seehafer, Stefan Pöhlmann, Dennis R Voelker, Christine Goffinet, Elke Pogge-von Strandmann, Uwe Bunz, Ralf Bartenschlager, Samir El Andaloussi, Konstantin M J Sparrer, Eva Herker, Stephan Becker, Frank Kirchhoff, Jan Münch, Janis A Müller
Some viruses are rarely transmitted orally or sexually despite their presence in saliva, breast milk, or semen. We previously identified that extracellular vesicles (EVs) in semen and saliva inhibit Zika virus infection. However, the antiviral spectrum and underlying mechanism remained unclear. Here we applied lipidomics and flow cytometry to show that these EVs expose phosphatidylserine (PS). By blocking PS receptors, targeted by Zika virus in the process of apoptotic mimicry, they interfere with viral attachment and entry...
March 25, 2024: Nature Microbiology
https://read.qxmd.com/read/38525304/cryogenic-electron-microscopy-and-tomography-reveal-imperfect-icosahedral-symmetry-in-alphaviruses
#8
JOURNAL ARTICLE
David Chmielewski, Guan-Chin Su, Jason T Kaelber, Grigore D Pintilie, Muyuan Chen, Jing Jin, Albert J Auguste, Wah Chiu
Alphaviruses are spherical, enveloped RNA viruses with two-layered icosahedral architecture. The structures of many alphaviruses have been studied using cryogenic electron microscopy (cryo-EM) reconstructions, which impose icosahedral symmetry on the viral particles. Using cryogenic electron tomography (cryo-ET), we revealed a polarized symmetry defect in the icosahedral lattice of Chikungunya virus (CHIKV) in situ, similar to the late budding particles, suggesting the inherent imperfect symmetry originates from the final pinch-off of assembled virions...
March 2024: PNAS Nexus
https://read.qxmd.com/read/38522648/the-impact-of-symbiotic-insect-specific-viruses-on-mosquito-vector-competence-for-arboviruses
#9
REVIEW
Isaque J S de Faria, João P P de Almeida, João Trindade Marques
Mosquitoes are vectors for arboviruses such as dengue, Zika, and Chikungunya. Symbiotic interactions can affect the intrinsic ability of mosquitoes to acquire and transmit arboviruses, e.g., vector competence. Insect specific viruses (ISVs) are commonly found in symbiotic associations with mosquitoes in the wild and can affect many aspects of mosquito biology. Here, we review current knowledge on the effects of symbiotic ISV-mosquito interactions on vector competence. We discuss potential mechanisms underlying these interactions and their implications for shaping new biological control strategies...
March 22, 2024: Current Opinion in Insect Science
https://read.qxmd.com/read/38517841/genomic-and-eco-epidemiological-investigations-in-uruguay-reveal-local-chikungunya-virus-transmission-dynamics-during-its-expansion-across-the-americas-in-2023
#10
JOURNAL ARTICLE
Analía Burgueño, Marta Giovanetti, Vagner Fonseca, Noelia Morel, Mauricio Lima, Emerson Castro, Natália R Guimarães, Felipe C M Iani, Victoria Bormida, Maria Noel Cortinas, Viviana Ramas, Leticia Coppola, Ana I Bento, Leticia Franco, Jairo Mendez Rico, José Lourenço, Luiz Carlos Junior Alcantara, Hector Chiparelli
Uruguay experienced its first Chikungunya virus outbreak in 2023, resulting in a significant burden to its healthcare system. We conducted analysis based on real-time genomic surveillance (30 novel whole genomes) to offer timely insights into recent local transmission dynamics and eco-epidemiological factors behind its emergence and spread in the country.
March 22, 2024: Emerging Microbes & Infections
https://read.qxmd.com/read/38507338/cytokine-and-t-cell-responses-in-post-chikungunya-viral-arthritis-a-cross-sectional-study
#11
JOURNAL ARTICLE
Aileen Y Chang, Sarah R Tritsch, Carlos Andres Herrera Gomez, Liliana Encinales, Andres Cadena Bonfanti, Wendy Rosales, Evelyn Mendoza-Torres, Samuel Simmens, Richard L Amdur, Christopher N Mores, Paige Fierbaugh, Carlos Alberto Perez Hernandez, Geraldine Avendaño, Paula Bruges Silvera, Yerlenis Galvis Crespo, Alberto David Cabana Jimenez, Jennifer Carolina Martinez Zapata, Dennys Jimenez, Estefanie Osorio-Llanes, Jairo Castellar-Lopez, Karol Suchowiecki, Karen Martins, Melissa Gregory, Ivan Zuluaga, Abigale Proctor, Alfonso Sucerquia Hernández, Leandro Sierra-Carrero, Maria Villanueva Colpas, Juan Carlos Perez Hernandez, Andres Alberto Figueroa Quast, Joaquin Andres Calderon De Barros, José Forero Mejía, Johan Penagos Ruiz, David Boyle, Gary S Firestein, Gary L Simon
OBJECTIVE: To define the relationship between chronic chikungunya post-viral arthritis disease severity, cytokine response and T cell subsets in order to identify potential targets for therapy. METHODS: Participants with chikungunya arthritis were recruited from Colombia from 2019-2021. Arthritis disease severity was quantified using the Disease Activity Score-28 and an Arthritis-Flare Questionnaire adapted for chikungunya arthritis. Plasma cytokine concentrations (interleukin (IL)-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-13, interferon-γ and tumor necrosis factor (TNF)) were measured using a Meso Scale Diagnostics assay...
2024: PloS One
https://read.qxmd.com/read/38498846/post-chikungunya-pigmentation
#12
JOURNAL ARTICLE
Swathi Kiran, Praveen Kumar Tirlangi, Nitin Gupta, Kavitha Saravu
No abstract text is available yet for this article.
March 18, 2024: QJM: Monthly Journal of the Association of Physicians
https://read.qxmd.com/read/38497839/clinical-and-laboratory-diagnosis-of-mayaro-virus-mayv-current-status-and-opportunities-for-further-development
#13
REVIEW
Severino Jefferson Ribeiro da Silva, Larissa Krokovsky
The recent outbreaks related to Mayaro virus (MAYV) infection in the Americas have brought this neglected virus as a potential threat to global public health. Given the range of symptoms that can be associated with MAYV infection, it can be challenging to diagnose individuals based on clinical signs, especially in countries with simultaneous circulation of other mosquito-borne viruses, such as dengue virus (DENV) and chikungunya virus (CHIKV). With this challenge in mind, laboratory-based diagnosis assumes a critical role in the introduction of measures to help prevent virus dissemination and to adequately treat patients...
March 2024: Reviews in Medical Virology
https://read.qxmd.com/read/38494642/chikungunya-fever-with-a-positive-tourniquet-test-a-novel-description
#14
JOURNAL ARTICLE
Miguel Mansilla-Polo, Ignacio Torres-Navarro, Daniel Martín-Torregrosa, Javier López-Davia, Rafael Botella-Estrada
No abstract text is available yet for this article.
March 18, 2024: Clinical and Experimental Dermatology
https://read.qxmd.com/read/38490342/%C3%AE-d-n-4-hydroxycytidine-nhc-eidd-1931-inhibits-chikungunya-virus-replication-in-mosquito-cells-and-ex-vivo-aedes-aegypti-guts-but-not-when-ingested-during-blood-feeding
#15
JOURNAL ARTICLE
Ana Lucia Rosales-Rosas, Alina Soto, Lanjiao Wang, Raf Mols, Albin Fontaine, Aboubakar Sanon, Patrick Augustijns, Leen Delang
Chikungunya virus (CHIKV) is a mosquito-borne virus transmitted by Aedes mosquitoes. While there are no antiviral therapies currently available to treat CHIKV infections, several licensed oral drugs have shown significant anti-CHIKV activity in cells and in mouse models. However, the efficacy in mosquitoes has not yet been assessed. Such cross-species antiviral activity could be favorable, since virus inhibition in the mosquito vector might prevent further transmission to vertebrate hosts. Here, we explored the antiviral effect of β-d-N4 -hydroxycytidine (NHC, EIDD-1931), the active metabolite of molnupiravir, on CHIKV replication in Aedes aegypti mosquitoes...
March 13, 2024: Antiviral Research
https://read.qxmd.com/read/38489894/arctigenin-from-arctium-lappa-l-inhibits-chikungunya-virus-by-affecting-its-entry-and-replication
#16
JOURNAL ARTICLE
Shridhar Shukla, Mahadeo Kakade, Sarah Cherian, Kalichamy Alagarasu, Deepti Parashar
BACKGROUND: Dengue and chikungunya, caused by dengue virus (DENV) and chikungunya virus (CHIKV) respectively, are the most common arthropod-borne viral diseases worldwide, for which there are no FDA-approved antivirals or effective vaccines. Arctigenin, a phenylpropanoid lignan from the seeds of Arctium lappa L. is known for its anti-inflammatory, anti-cancer, antibacterial, and immunomodulatory properties. Arctigenin's antimicrobial and immunomodulatory capabilities make it a promising candidate for investigating its potential as an anti-DENV and anti-CHIKV agent...
February 27, 2024: Phytomedicine
https://read.qxmd.com/read/38488850/oxidative-stress-governs-mosquito-innate-immune-signalling-to-reduce-chikungunya-virus-infection-in-aedes-derived-cells
#17
JOURNAL ARTICLE
Divya Mehta, Sakshi Chaudhary, Sujatha Sunil
Arboviruses such as chikungunya, dengue and zika viruses cause debilitating diseases in humans. The principal vector species that transmits these viruses is the Aedes mosquito. Lack of substantial knowledge of the vector species hinders the advancement of strategies for controlling the spread of arboviruses. To supplement our information on mosquitoes' responses to virus infection, we utilized Aedes aegypti- derived Aag2 cells to study changes at the transcriptional level during infection with chikungunya virus (CHIKV)...
March 2024: Journal of General Virology
https://read.qxmd.com/read/38484041/successful-introgression-of-wmel-wolbachia-into-aedes-aegypti-populations-in-fiji-vanuatu-and-kiribati
#18
JOURNAL ARTICLE
Cameron P Simmons, Wesley Donald, Lekon Tagavi, Len Tarivonda, Timothy Quai, Raynelyn Tavoa, Tebikau Noran, Erirau Manikaoti, Lavinia Kareaua, Tabomoa Tinte Abwai, Dip Chand, Vineshwaran Rama, Vimal Deo, Kharishma Karti Deo, Aminiasi Tavuii, Wame Valentine, Ravi Prasad, Eremasi Seru, Leikitah Naituku, Anaseini Ratu, Mark Hesketh, Nichola Kenny, Sarah C Beebe, Anjali A Goundar, Andrew McCaw, Molly Buntine, Ben Green, Tibor Frossard, Jeremie R L Gilles, D Albert Joubert, Geoff Wilson, Le Quyen Duong, Jean B Bouvier, Darren Stanford, Carolyn Forder, Johanna M Duyvestyn, Etiene C Pacidônio, Heather A Flores, Natalie Wittmeier, Kate Retzki, Peter A Ryan, Jai A Denton, Ruth Smithyman, Stephanie K Tanamas, Peter Kyrylos, Yi Dong, Anam Khalid, Lauren Hodgson, Katherine L Anders, Scott L O'Neill
Pacific Island countries have experienced periodic dengue, chikungunya and Zika outbreaks for decades. The prevention and control of these mosquito-borne diseases rely heavily on control of Aedes aegypti mosquitoes, which in most settings are the primary vector. Introgression of the intracellular bacterium Wolbachia pipientis (wMel strain) into Ae. aegypti populations reduces their vector competence and consequently lowers dengue incidence in the human population. Here we describe successful area-wide deployments of wMel-infected Ae...
March 14, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38484018/cryptic-circulation-of-chikungunya-virus-in-s%C3%A3-o-jose-do-rio-preto-brazil-2015-2019
#19
JOURNAL ARTICLE
Nathalia Zini, Matheus Henrique Tavares Ávila, Natalia Morbi Cezarotti, Maisa Carla Pereira Parra, Cecília Artico Banho, Livia Sacchetto, Andreia Francesli Negri, Emerson Araújo, Cintia Bittar, Bruno Henrique Gonçalves de Aguiar Milhin, Victor Miranda Hernandes, Karina Rocha Dutra, Leonardo Agopian Trigo, Leonardo Cecílio da Rocha, Rafael Alves da Silva, Gislaine Celestino Dutra da Silva, Tamires Fernanda Pereira Dos Santos, Beatriz de Carvalho Marques, Andresa Lopes Dos Santos, Marcos Tayar Augusto, Natalia Franco Bueno Mistrão, Milene Rocha Ribeiro, Tauyne Menegaldo Pinheiro, Thayza Maria Izabel Lopes Dos Santos, Clarita Maria Secco Avilla, Victoria Bernardi, Caroline Freitas, Flora de Andrade Gandolfi, Hélio Correa Ferraz Júnior, Gabriela Camilotti Perim, Mirella Cezare Gomes, Pedro Henrique Carrilho Garcia, Rodrigo Sborghi Rocha, Tayna Manfrin Galvão, Eliane Aparecida Fávaro, Samuel Noah Scamardi, Karen Sanmartin Rogovski, Renan Luiz Peixoto, Luiza Benfatti, Leonardo Teixeira Cruz, Paula Patricia de Freitas Chama, Mânlio Tasso Oliveira, Aripuanã Sakurada Aranha Watanabe, Ana Carolina Bernardes Terzian, Alice de Freitas Versiani, Margareth Regina Dibo, Francisco Chiaravalotti-Neto, Scott Cameron Weaver, Cassia Fernanda Estofolete, Nikos Vasilakis, Mauricio Lacerda Nogueira
BACKGROUND: Chikungunya virus (CHIKV) has spread across Brazil with varying incidence rates depending on the affected areas. Due to cocirculation of arboviruses and overlapping disease symptoms, CHIKV infection may be underdiagnosed. To understand the lack of CHIKV epidemics in São José do Rio Preto (SJdRP), São Paulo (SP), Brazil, we evaluated viral circulation by investigating anti-CHIKV IgG seroconversion in a prospective study of asymptomatic individuals and detecting anti-CHIKV IgM in individuals suspected of dengue infection, as well as CHIKV presence in Aedes mosquitoes...
March 14, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38483968/chikungunya-virus-infection-disrupts-mhc-i-antigen-presentation-via-nonstructural-protein-2
#20
JOURNAL ARTICLE
Brian C Ware, M Guston Parks, Mariana O L da Silva, Thomas E Morrison
Infection by chikungunya virus (CHIKV), a mosquito-borne alphavirus, causes severe polyarthralgia and polymyalgia, which can last in some people for months to years. Chronic CHIKV disease signs and symptoms are associated with the persistence of viral nucleic acid and antigen in tissues. Like humans and nonhuman primates, CHIKV infection in mice results in the development of robust adaptive antiviral immune responses. Despite this, joint tissue fibroblasts survive CHIKV infection and can support persistent viral replication, suggesting that they escape immune surveillance...
March 14, 2024: PLoS Pathogens
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