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https://www.readbyqxmd.com/read/28525510/zika-virus-obstetric-and-pediatric-anesthesia-considerations
#1
Jacqueline L Tutiven, Benjamin T Pruden, James S Banks, Mario Stevenson, David J Birnbach
As of November 2016, the Florida Department of Health (FDH) and the Centers for Disease Control and Prevention have confirmed more than 4000 travel-related Zika virus (ZIKV) infections in the United States with >700 of those in Florida. There have been 139 cases of locally acquired infection, all occurring in Miami, Florida. Within the US territories (eg, Puerto Rico, US Virgin Islands), >30,000 cases of ZIKV infection have been reported. The projected number of individuals at risk for ZIKV infection in the Caribbean and Latin America approximates 5 million...
June 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28524874/impact-of-simultaneous-exposure-to-arboviruses-on-infection-and-transmission-by-aedes-aegypti-mosquitoes
#2
Claudia Rückert, James Weger-Lucarelli, Selene M Garcia-Luna, Michael C Young, Alex D Byas, Reyes A Murrieta, Joseph R Fauver, Gregory D Ebel
The recent emergence of both chikungunya and Zika viruses in the Americas has significantly expanded their distribution and has thus increased the possibility that individuals may become infected by more than one Aedes aegypti-borne virus at a time. Recent clinical data support an increase in the frequency of coinfection in human patients, raising the likelihood that mosquitoes could be exposed to multiple arboviruses during one feeding episode. The impact of coinfection on the ability of relevant vector species to transmit any of these viruses (that is, their vector competence) has not been determined...
May 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/28518022/high-frequency-of-mayaro-virus-igm-among-febrile-patients-central-brazil
#3
Sandra Brunini, Divânia Dias Silva França, Juliana Brasiel Silva, Leandro Nascimento Silva, Flúvia Pereira Amorim Silva, Mariana Spadoni, Giovanni Rezza
Mayaro virus (MAYV), an Aedes mosquito-borne alphavirus, is endemic to Brazil and other South America countries. We investigated dengue- and chikungunya-negative febrile patients visiting rural areas near Goiânia, Goiás, and found a high proportion (55%) of MAYV IgM. Our findings suggest the presence of highly endemic foci of MAYV in central Brazil.
June 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28517033/high-throughput-sequencing-of-transposable-element-insertions-suggests-adaptive-evolution-of-the-invasive-asian-tiger-mosquito-towards-temperate-environments
#4
Clément Goubert, Hélène Henri, Guillaume Minard, Claire Valiente Moro, Patrick Mavingui, Cristina Vieira, Matthieu Boulesteix
Invasive species represent unique opportunities to evaluate the role of local adaptation during colonization of new environments. Among these species, the Asian tiger mosquito, Aedes albopictus, is a threatening vector of several human viral diseases, including dengue and chikungunya, and raises concerns about the Zika fever. Its broad presence in both temperate and tropical environments has been considered the reflection of great "ecological plasticity". However, no study has been conducted to assess the role of adaptive evolution in the ecological success of Ae...
May 18, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28515133/development-of-a-novel-virus-like-particle-vaccine-platform-that-mimics-immature-form-of-alphavirus
#5
Akane Urakami, Atsuko Sakurai, Momoko Ishikawa, Moh Lan Yap, Yevel Flores-Garcia, Yasunari Haseda, Taiki Aoshi, Fidel P Zavala, Michael G Rossmann, Sachiko Kuno, Ryuji Ueno, Wataru Akahata
Virus-like particles (VLPs) are non-infectious multiprotein structures that are engineered to self-assemble from viral structural proteins. Here, we developed a novel VLP-based vaccine platform utilizing VLPs from the Chikungunya virus. We identified two regions within the envelope protein, a structural component of Chikungunya, where foreign antigens can be inserted without compromising VLP structure. Our VLP displays 480 copious copies of an inserted antigen on the VLP surface in a highly symmetric manner, thus capable of inducing strong immune responses against any inserted antigen...
May 17, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28514227/real-time-evolution-of-zika-virus-disease-outbreak-roat%C3%A3-n-honduras
#6
Trevor Brooks, Arup Roy-Burman, Cascade Tuholske, Michael P Busch, Sonia Bakkour, Mars Stone, Jeffrey M Linnen, Kui Gao, Jayleen Coleman, Evan M Bloch
A Zika virus disease outbreak occurred in Roatán, Honduras, during September 2015-July 2016. Blood samples and clinical information were obtained from 183 patients given a clinical diagnosis of suspected dengue virus infection. A total of 79 patients were positive for Zika virus, 13 for chikungunya virus, and 6 for dengue virus.
August 17, 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28509947/-arboviruses-also-have-an-american-dream
#7
F Rodhain
Some arboviruses that originated in the Old World have been introduced by humans into the American continent. The first of them was the yellow fever virus, coming from the West African coast with slaves in the 17th-19th centuries, followed by dengue viruses, which were always prevalent within the Americas. Next was theWest Nile virus, introduced in New York in 1999, that spread in only a few years over the whole continent. Then, Chikungunya virus arrived on Saint Martin Island in 2013 after its outbreak in Polynesia; it is now widespread in the Caribbean Islands and on the American continent from the United States to Brazil...
May 16, 2017: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/28506207/the-midgut-transcriptome-of-aedes-aegypti-fed-with-saline-or-protein-meals-containing-chikungunya-virus-reveals-genes-potentially-involved-in-viral-midgut-escape
#8
Shengzhang Dong, Susanta K Behura, Alexander W E Franz
BACKGROUND: The mosquito Aedes aegypti is the primary vector for medically important arthropod-borne viruses, including chikungunya virus (CHIKV). Following oral acquisition, an arbovirus has to persistently infect several organs in the mosquito before becoming transmissible to another vertebrate host. A major obstacle an arbovirus has to overcome during its infection cycle inside the mosquito is the midgut escape barrier, representing the exit mechanism arboviruses utilize when disseminating from the midgut...
May 15, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28504449/a-decade-of-colonization-the-spread-of-the-asian-tiger-mosquito-in-pennsylvania-and-implications-for-disease-risk
#9
Eric D Taber, Michael L Hutchinson, Erica A H Smithwick, Justine I Blanford
In recent decades, the Asian tiger mosquito expanded its geographic range throughout the northeastern United States, including Pennsylvania. The establishment of Aedes albopictus in novel areas raises significant public health concerns, since this species is a highly competent vector of several arboviruses, including chikungunya, West Nile, and dengue. In this study, we used geographic information systems (GIS) to examine a decade of colonization by Ae. albopictus throughout Pennsylvania between 2001 and 2010...
June 2017: Journal of Vector Ecology: Journal of the Society for Vector Ecology
https://www.readbyqxmd.com/read/28503297/cardiovascular-involvement-and-manifestations-of-systemic-chikungunya-virus-infection-a-systematic-review
#10
María Fernanda Alvarez, Adrián Bolívar-Mejía, Alfonso J Rodriguez-Morales, Eduardo Ramirez-Vallejo
BACKGROUND: In the last three years, chikungunya virus disease has been spreading, affecting particularly the Americas, producing more than two million cases. In this setting, not only new disease-related epidemiological patterns have been found, but also new clinical findings have been reported by different research groups. These include findings on the cardiovascular system, including clinical, electrocardiographic and echocardiographic alterations. No previous systemic reviews have been found in major databases about it...
2017: F1000Research
https://www.readbyqxmd.com/read/28499011/fatal-case-of-chikungunya-and-concomitant-thrombotic-thrombocytopenic-purpura-in-french-guiana-during-air-flight-medical-evacuation
#11
Loïc Epelboin, Bastien Bidaud, Emilie Mosnier, Paul Le Turnier, Guillaume Vesin, Gaëlle Walter, Philippe Abboud, Stéphanie Houcke, Maïa Forgues, Gérald Egmann, Alain Stepanian, Félix Djossou
Thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy associated to severe ADAMTS13 deficiency. It has been linked to various viral infections. Among arboviruses, only Crimean-Congo haemorrhagic fever and dengue fever have been linked to this severe disease. We report the first documented case of TTP concomitant to Chikungunya virus infection.
September 1, 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28497119/aedes-aegypti-piwi4-is-a-noncanonical-piwi-protein-involved-in-antiviral-responses
#12
Margus Varjak, Kevin Maringer, Mick Watson, Vattipally B Sreenu, Anthony C Fredericks, Emilie Pondeville, Claire L Donald, Jelle Sterk, Joy Kean, Marie Vazeille, Anna-Bella Failloux, Alain Kohl, Esther Schnettler
The small interfering RNA (siRNA) pathway is a major antiviral response in mosquitoes; however, another RNA interference pathway, the PIWI-interacting RNA (piRNA) pathway, has been suggested to be antiviral in mosquitoes. Piwi4 has been reported to be a key mediator of this response in mosquitoes, but it is not involved in the production of virus-specific piRNAs. Here, we show that Piwi4 associates with members of the antiviral exogenous siRNA pathway (Ago2 and Dcr2), as well as with proteins of the piRNA pathway (Ago3, Piwi5, and Piwi6) in an Aedes aegypti-derived cell line, Aag2...
May 2017: MSphere
https://www.readbyqxmd.com/read/28495775/complete-coding-sequence-of-a-case-of-chikungunya-virus-imported-into-australia
#13
Bixing Huang, Alyssa T Pyke, Jamie McMahon, David Warrilow
A case of chikungunya virus infection was imported from India into Australia in late 2016. Infection was diagnosed by real-time reverse transcription-PCR and confirmed by culture isolation and genome sequencing. Phylogenetic analysis of the genome sequence indicated that the virus grouped with the east/central/south African genotype.
May 11, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28495485/mosquito-biting-modulates-skin-response-to-virus-infection
#14
REVIEW
Marieke Pingen, Michael A Schmid, Eva Harris, Clive S McKimmie
Mosquito-borne infections are increasing in number and are spreading to new regions at an unprecedented rate. In particular, mosquito-transmitted viruses, such as those that cause Zika, dengue, West Nile encephalitis, and chikungunya, have become endemic or have caused dramatic epidemics in many parts of the world. Aedes and Culex mosquitoes are the main culprits, spreading infection when they bite. Importantly, mosquitoes do not act as simple conduits that passively transfer virus from one individual to another...
May 8, 2017: Trends in Parasitology
https://www.readbyqxmd.com/read/28494087/investigation-of-twenty-selected-medicinal-plants-from-malaysia-for-anti-chikungunya-virus-activity
#15
Yik Sin Chan, Kong Soo Khoo, Nam Weng Weng Sit
Chikungunya virus is a reemerging arbovirus transmitted mainly by Aedes mosquitoes. As there are no specific treatments available, Chikungunya virus infection is a significant public health problem. This study investigated 120 extracts from selected medicinal plants for anti-Chikungunya virus activity. The plant materials were subjected to sequential solvent extraction to obtain six different extracts for each plant. The cytotoxicity and antiviral activity of each extract were examined using African monkey kidney epithelial (Vero) cells...
September 2016: International Microbiology: the Official Journal of the Spanish Society for Microbiology
https://www.readbyqxmd.com/read/28488960/towards-pathogen-inactivation-of-red-blood-cells-and-whole-blood-targeting-viral-dna-rna-design-technologies-and-future-prospects-for-developing-countries
#16
REVIEW
Victor J Drew, Lassina Barro, Jerard Seghatchian, Thierry Burnouf
Over 110 million units of blood are collected yearly. The need for blood products is greater in developing countries, but so is the risk of contracting a transfusion-transmitted infection. Without efficient donor screening/viral testing and validated pathogen inactivation technology, the risk of transfusion-transmitted infections correlates with the infection rate of the donor population. The World Health Organization has published guidelines on good manufacturing practices in an effort to ensure a strong global standard of transfusion and blood product safety...
April 13, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28487212/mapping-the-ecoepidemiology-of-zika-virus-infection-in-urban-and-rural-areas-of-pereira-risaralda-colombia-2015-2016-implications-for-public-health-and-travel-medicine
#17
Alfonso J Rodriguez-Morales, Pablo Ruiz, Javier Tabares, Carlos Augusto Ossa, Maria Camila Yepes-Echeverry, Valeria Ramirez-Jaramillo, Maria Leonor Galindo-Marquez, Carlos Julian García-Loaiza, Juan Alejandro Sabogal-Roman, Esteban Parra-Valencia, Guillermo J Lagos-Grisales, Carlos O Lozada-Riascos, Cornelis A de Pijper, Martin P Grobusch
OBJECTIVE: Geographical information systems (GIS) have been demonstrated earlier to be of great use to inform public health action against vector-borne infectious diseases. METHODS: Using surveillance data on the ongoing ZIKV outbreak from Pereira, Colombia (2015-2016), we estimated incidence rates (cases/100,000 population), and developed maps correlating with the ecoepidemiology of the area. RESULTS: Up to October 8, 2016, 439 cases of ZIKV were reported in Pereira (93 cases/100,000 pop...
May 6, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/28483796/imaging-of-viral-neuroinvasion-in-the-zebrafish-reveals-that-sindbis-and-chikungunya-viruses-favour-different-entry-routes
#18
Gabriella Passoni, Christelle Langevin, Nuno Palha, Bryan C Mounce, Valérie Briolat, Pierre Affaticati, Elodie De Job, Jean-Stéphane Joly, Marco Vignuzzi, Maria-Carla Saleh, Philippe Herbomel, Pierre Boudinot, Jean-Pierre Levraud
Alphaviruses, such as chikungunya (CHIKV) and Sindbis virus (SINV), are vector‑borne pathogens that cause acute illnesses in humans and are sometimes associated with neuropathies, especially in infants and elderly patients. Little is known about their entry mechanism in the central nervous system (CNS), even for SINV, which has been used extensively as a model for viral encephalopathies. We previously established a CHIKV infection model in the optically transparent zebrafish larva; here we describe a new SINV infection model in this host...
May 8, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28480053/understanding-the-evolution-and-spread-of-chikungunya-virus-in-the-americas-using-complete-genome-sequences
#19
N S D Sahadeo, O M Allicock, P M De Salazar, A J Auguste, S Widen, B Olowokure, C Gutierrez, A M Valadere, K Polson-Edwards, S C Weaver, C V F Carrington
Local transmission of chikungunya virus (CHIKV) was first detected in the Americas in December 2013, after which it spread rapidly throughout the Caribbean islands and American mainland, causing a major chikungunya fever epidemic. Previous phylogenetic analysis of CHIKV from a limited number of countries in the Americas suggests that an Asian genotype strain was responsible, except in Brazil where both Asian and East/Central/South African (ECSA) lineage strains were detected. In this study, we sequenced thirty-three complete CHIKV genomes from viruses isolated in 2014 from fourteen Caribbean islands, the Bahamas and two mainland countries in the Americas...
January 2017: Virus Evolution
https://www.readbyqxmd.com/read/28469032/rapid-and-specific-detection-of-asian-and-african-lineage-zika-viruses
#20
Nunya Chotiwan, Connie D Brewster, Tereza Magalhaes, James Weger-Lucarelli, Nisha K Duggal, Claudia Rückert, Chilinh Nguyen, Selene M Garcia Luna, Joseph R Fauver, Barb Andre, Meg Gray, William C Black, Rebekah C Kading, Gregory D Ebel, Guillermina Kuan, Angel Balmaseda, Thomas Jaenisch, Ernesto T A Marques, Aaron C Brault, Eva Harris, Brian D Foy, Sandra L Quackenbush, Rushika Perera, Joel Rovnak
Understanding the dynamics of Zika virus transmission and formulating rational strategies for its control require precise diagnostic tools that are also appropriate for resource-poor environments. We have developed a rapid and sensitive loop-mediated isothermal amplification (LAMP) assay that distinguishes Zika viruses of Asian and African lineages. The assay does not detect chikungunya virus or flaviviruses such as dengue, yellow fever, or West Nile viruses. The assay conditions allowed direct detection of Zika virus RNA in cultured infected cells; in mosquitoes; in virus-spiked samples of human blood, plasma, saliva, urine, and semen; and in infected patient serum, plasma, and semen samples without the need for RNA isolation or reverse transcription...
May 3, 2017: Science Translational Medicine
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