Read by QxMD icon Read


Donal Bisanzio, Felipe Dzul-Manzanilla, Hector Gomez-Dantés, Norma Pavia-Ruz, Thomas J Hladish, Audrey Lenhart, Jorge Palacio-Vargas, Jesus F González Roldan, Fabian Correa-Morales, Gustavo Sánchez-Tejeda, Pablo Kuri Morales, Pablo Manrique-Saide, Ira M Longini, M Elizabeth Halloran, Gonzalo M Vazquez-Prokopec
Response to Zika virus (ZIKV) invasion in Brazil lagged a year from its estimated February 2014 introduction, and was triggered by the occurrence of severe congenital malformations. Dengue (DENV) and chikungunya (CHIKV) invasions tend to show similar response lags. We analyzed geo-coded symptomatic case reports from the city of Merida, Mexico, with the goal of assessing the utility of historical DENV data to infer CHIKV and ZIKV introduction and propagation. About 42% of the 40,028 DENV cases reported during 2008-2015 clustered in 27% of the city, and these clustering areas were where the first CHIKV and ZIKV cases were reported in 2015 and 2016, respectively...
March 15, 2018: PLoS Neglected Tropical Diseases
Azael Che-Mendoza, Anuar Medina-Barreiro, Edgar Koyoc-Cardeña, Valentín Uc-Puc, Yamili Contreras-Perera, Josué Herrera-Bojórquez, Felipe Dzul-Manzanilla, Fabian Correa-Morales, Hilary Ranson, Audrey Lenhart, Philip J McCall, Axel Kroeger, Gonzalo Vazquez-Prokopec, Pablo Manrique-Saide
BACKGROUND: There is a need for effective methods to control Aedes aegypti and prevent the transmission of dengue, chikungunya, yellow fever and Zika viruses. Insecticide treated screening (ITS) is a promising approach, particularly as it targets adult mosquitoes to reduce human-mosquito contact. METHODOLOGY/PRINCIPAL FINDINGS: A cluster-randomised controlled trial evaluated the entomological efficacy of ITS based intervention, which consisted of the installation of pyrethroid-impregnated long-lasting insecticide-treated netting material fixed as framed screens on external doors and windows...
March 15, 2018: PLoS Neglected Tropical Diseases
José Sánchez-Carbonel, Derek Tantaléan-Yépez, Miguel Angel Aguilar-Luis, Wilmer Silva-Caso, Pablo Weilg, Fernando Vásquez-Achaya, Luis Costa, Johanna Martins-Luna, Isabel Sandoval, Juana Del Valle-Mendoza
OBJECTIVE: To assess the presence of Dengue, Chikungunya, and Zika in serum samples of patients with acute febrile illness in Piura, Peru and describe the most common clinical features. RESULTS: Dengue was the most common arbovirus detected in 170/496 (34.3%), followed by Zika in 39/496 (7.9%) and Chikungunya in 23/496 (4.6%). Among the 170 samples positive for Dengue, serotype 2 was the most predominant type present in 97/170 (57.1%) of samples, followed by the serotype 3 in 9/170 (5...
March 14, 2018: BMC Research Notes
Imelda Menchaca-Armenta, Moisés Ocampo-Torres, Arnulfo Hernández-Gómez, Karen Zamora-Cerritos
Diseases caused by viruses such as dengue, chikungunya and zika are mosquito-borne diseases transmitted by Aedes aegypti. We performed a cross-sectional study of healthcare personnel and the general population using questionnaires to identify the level of knowledge, attitudes and practices, and risk perception for dengue, chikungunya and zika. A total of 248 questionnaires were applied, 63.3% to healthcare personnel and 36.7% to the general population. Of the healthcare personnel, 53% were men, and in the general population 74% were women...
March 8, 2018: Revista do Instituto de Medicina Tropical de São Paulo
Yanouk Epelboin, Sarah C Chaney, Amandine Guidez, Nausicaa Habchi-Hanriot, Stanislas Talaga, Lanjiao Wang, Isabelle Dusfour
Since the 1940s, French Guiana has implemented vector control to contain or eliminate malaria, yellow fever, and, recently, dengue, chikungunya, and Zika. Over time, strategies have evolved depending on the location, efficacy of the methods, development of insecticide resistance, and advances in vector control techniques. This review summarises the history of vector control in French Guiana by reporting the records found in the private archives of the Institute Pasteur in French Guiana and those accessible in libraries worldwide...
March 12, 2018: Memórias do Instituto Oswaldo Cruz
C Talero-Gutiérrez, A Rivera-Molina, C Pérez-Pavajeau, I Ossa-Ospina, C Santos-García, M C Rojas-Anaya, A de-la-Torre
Zika virus (ZIKV) infection is an emergent worldwide public health problem. Historically, 84 countries have reported vector-borne ZIKV transmission, 61 of which report on-going transmission. It is a Flavivirus transmitted through arthropods belonging to the Aedes genus. Since 2015, ZIKV infections have increased dramatically; with 1.3 million people infected during 2015 in Brazil alone. This paper's objective is to highlight the conjectural epidemiological points of the virus' dissemination. The digital archives Pubmed, MEDLINE, EMBASE and Cochrane were searched for papers that assessed aspects of ZIKV transmission and epidemiology...
March 14, 2018: Epidemiology and Infection
José Kennedy Amaral, Robert T Schoen
INTRODUCTION: Chronic chikungunya (CHIK) arthritis, an inflammatory arthritis, often follows acute CHIK fever (CHIKF), a viral infection. The pathogenesis of chronic CHIK arthritis is poorly characterized, but may resemble other forms of inflammatory arthritis. Clinically, chronic CHIK arthritis sometimes mimics rheumatoid arthritis (RA). CASE REPORT: We report a patient with well-characterized CHIKF followed 2 months later by chronic CHIK arthritis not only resembling RA clinically, but also associated with RA biomarkers and extra-articular features, including Felty's syndrome (FS)...
March 13, 2018: Rheumatology and Therapy
Benjamin M Althouse, Mathilde Guerbois, Derek A T Cummings, Ousmane M Diop, Ousmane Faye, Abdourahmane Faye, Diawo Diallo, Bakary Djilocalisse Sadio, Abdourahmane Sow, Oumar Faye, Amadou A Sall, Mawlouth Diallo, Brenda Benefit, Evan Simons, Douglas M Watts, Scott C Weaver, Kathryn A Hanley
Arboviruses spillover into humans either as a one-step jump from a reservoir host species into humans or as a two-step jump from the reservoir to an amplification host species and thence to humans. Little is known about arbovirus transmission dynamics in reservoir and amplification hosts. Here we elucidate the role of monkeys in the sylvatic, enzootic cycle of chikungunya virus (CHIKV) in the region around Kédougou, Senegal. Over 3 years, 737 monkeys were captured, aged using anthropometry and dentition, and tested for exposure to CHIKV by detection of neutralizing antibodies...
March 13, 2018: Nature Communications
Alyssa T Pyke, Peter R Moore, Jamie McMahon
No abstract text is available yet for this article.
March 14, 2018: Emerging Microbes & Infections
Aruna Narula, Rajan Kumar Pandey, Nazia Khatoon, Amit Mishra, Vijay Kumar Prajapati
Chikungunya infection has been a cause of countless deaths worldwide. Due to lack of permanent treatment and prevention of this disease, the mortality rate remains very high. Therefore, we followed an immunoinformatics approach for the development of multi-epitope subunit vaccine which is able to elucidate humoral, cell-mediated and innate immune responses inside the host body. Both structural and non-structural proteins of chikungunya virus were utilized for prediction of B-cell and T-cell binding epitopes along with interferon-γ (IFN-γ) inducing epitopes...
March 10, 2018: Infection, Genetics and Evolution
Maria Grazia Dente, Flavia Riccardo, Gloria Nacca, Alessia Ranghiasci, Camille Escadafal, Lobna Gaayeb, Miguel Angel Jiménez-Clavero, Jean-Claude Manuguerra, Marie Picard, Jovita Fernández-Pinero, Elisa Pérez-Ramírez, Vincent Robert, Kathleen Victoir, Silvia Declich
In the context of One Health, there is presently an effort to integrate surveillance of human, animal, entomological, and environmental sectors. This aims to strengthen the prevention of, and preparedness against, arbovirus infections, also in the light of environmental and climate changes that could increase the risk of transmission. However, criteria to define integrated surveillance, and to compare different systems, still need to be identified and tested. We conducted a scoping review to identify and examine surveillance systems for West Nile virus (WNV), chikungunya virus (CHKV), dengue virus (DENV), and Rift Valley fever virus (RVFV), which involve human, animal, entomological, and environmental sectors...
March 10, 2018: International Journal of Environmental Research and Public Health
Marta Runowska, Dominik Majewski, Karolina Niklas, Mariusz Puszczewicz
Chikungunya virus (CHIKV) is an arthropod-borne alphavirus, transmitted by Aedes aegypti and Aedes albopictus mosquitoes. It is responsible for a febrile illness, typically accompanied by maculopapular rash and severe, incapacitating arthralgia. The disease, although generally self-limiting, frequently evolves into a long-lasting, debilitating rheumatic disorder, which shares many clinical features with rheumatoid arthritis (RA). The underlying mechanism by which CHIKV induces persistent arthritis remains under investigation, however, currently, attention is drawn to the fact, that chronic chikungunya (CHIK) and RA have many common cellular and cytokine pathways involved in their pathogenesis...
March 2, 2018: Clinical and Experimental Rheumatology
Lusiele Guaraldo, Mayumi Duarte Wakimoto, Heloisa Ferreira, Clarisse Bressan, Guilherme Amaral Calvet, Geraldo Castelar Pinheiro, Andre Machado Siqueira, Patrícia Brasil
Chikungunya virus is amongst the fastest expanding vector transmissible diseases in recent years and has been causing massive epidemics in Africa, Asia, Latin America and the Caribbean. Despite human infection by this virus being first described in the 1950s, there is a lack of adequate therapeutic evaluations to guide evidence-based recommendations. The current guidelines rely heavily in specialists' opinion and experience instead of using higher rated evidence. Areas covered: A systematic review of the literature was performed- not restricted to clinical trials - reporting the therapeutic response against this infection with the intent to gather the best evidence of the treatment options against musculoskeletal disorders following chikungunya fever...
March 13, 2018: Expert Review of Anti-infective Therapy
Han Xia, Yujuan Wang, Evans Atoni, Bo Zhang, Zhiming Yuan
Mosquitoes are classified into approximately 3500 species and further grouped into 41 genera. Epidemiologically, they are considered to be among the most important disease vectors in the world and they can harbor a wide variety of viruses. Several mosquito viruses are considered to be of significant medical importance and can cause serious public health issues throughout the world. Such viruses are Japanese encephalitis virus (JEV), dengue virus (DENV), chikungunya virus (CHIKV), and Zika virus (ZIKV). Others are the newly recognized mosquito viruses such as Banna virus (BAV) and Yunnan orbivirus (YNOV) with unclear medical significance...
March 12, 2018: Virologica Sinica
Robin B McFee
No abstract text is available yet for this article.
March 9, 2018: Disease-a-month: DM
Angelina Kakooza-Mwesige, Abdul H Mohammed, Krister Kristensson, Sharon L Juliano, Julius J Lutwama
The global public health concern is heightened over the increasing number of emerging viruses, i.e., newly discovered or previously known that have expanded into new geographical zones. These viruses challenge the health-care systems in sub-Saharan Africa (SSA) countries from which several of them have originated and been transmitted by insects worldwide. Some of these viruses are neuroinvasive, but have been relatively neglected by neuroscientists. They may provide experiments by nature to give a time window for exposure to a new virus within sizeable, previously non-infected human populations, which, for instance, enables studies on potential long-term or late-onset effects on the developing nervous system...
2018: Frontiers in Neurology
Apamas Sukkaew, Montri Thanagith, Tipparat Thongsakulprasert, Margit Mutso, Suresh Mahalingam, Duncan R Smith, Sukathida Ubol
Low-passage clinical isolates of chikungunya virus (CHIKV) were found to be a mixture of large- and small-plaque viruses, with small-plaque viruses being the predominant species. To investigate the contribution of plaque variants to the pathology of the joint, primary human fibroblast-like synoviocytes (HFLS) were used. Large- and small-plaque viruses were purified from two clinical isolates, CHIKV-031C and CHIKV-033C, and were designated CHIKV-031L and CHIKV-031S and CHIKV-033L and CHIKV-033S, respectively...
March 8, 2018: Journal of General Virology
Aileen Y Chang, Liliana Encinales, Jeffrey M Bethony, Gary L Simon
Supported by the Rheumatology Research Foundation and the NIH (National Center for Advancing Translational Sciences grants UL1-TR-001876 and KL2-TR-001877). We would like to thank Mogami et. al., for sharing their experience with chikungunya virus in the Brazilian context, especially highlighting the possible utility of ultrasound during the sub-acute phase to identify severe or evolving cases of arthritis. Indeed, Doppler ultrasound may be an effective approach to identify patients that might benefit from treatment with disease modifying agents such as methotrexate during the sub-acute phase...
March 7, 2018: Arthritis & Rheumatology
Luciano Pamplona de Góes Cavalcanti, Sara Mendes D'angelo, Daniele Rocha Queiroz Lemos, Francisca Kalline de Almeida Barreto, André Machado Siqueira, Fabio Miyajima
INTRODUCTION: Chikungunya virus (CHIKV) can negatively influence outcomes in patients with pre-existing conditions. We investigated the association between the recent CHIKV outbreak and increased type 2 diabetes (T2D)-attributable deaths. METHODS: Monthly averages of T2D-attributable deaths between 2001 and 2016 were determined and compared to the equivalent data for 2017 and the recent CHIKV outbreak. RESULTS: CHKV outbreak peaked in April 2017 with 4,394...
January 2018: Revista da Sociedade Brasileira de Medicina Tropical
Josef Zapletal, Madhav Erraguntla, Zach N Adelman, Kevin M Myles, Mark A Lawley
The increasing range of Aedes aegypti, vector for Zika, dengue, chikungunya, and other viruses, has brought attention to the need to understand the population and transmission dynamics of this mosquito. It is well understood that environmental factors and breeding site characteristics play a role in organismal development and the potential to transmit pathogens. In this study, we observe the impact of larval density in combination with diurnal temperature on the time to pupation, emergence, and mortality of Aedes aegypti...
2018: PloS One
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"