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https://www.readbyqxmd.com/read/29342089/chitosan-gel-to-treat-pressure-ulcers-a-clinical-pilot-study
#1
Virginia Campani, Eliana Pagnozzi, Ilaria Mataro, Laura Mayol, Alessandra Perna, Floriana D'Urso, Antonietta Carillo, Maria Cammarota, Maria Chiara Maiuri, Giuseppe De Rosa
Chitosan is biopolymer with promising properties in wound healing. Chronic wounds represent a significant burden to both the patient and the medical system. Among chronic wounds, pressure ulcers are one of the most common types of complex wound. The efficacy and the tolerability of chitosan gel formulation, prepared into the hospital pharmacy, in the treatment of pressure ulcers of moderate severity were evaluated. The endpoint of this phase II study was the reduction of the area of the lesion by at least 20% after four weeks of treatment...
January 17, 2018: Pharmaceutics
https://www.readbyqxmd.com/read/29341658/floquet-symmetry-protected-topological-phases-in-cold-atom-systems
#2
I-D Potirniche, A C Potter, M Schleier-Smith, A Vishwanath, N Y Yao
We propose and analyze two distinct routes toward realizing interacting symmetry-protected topological (SPT) phases via periodic driving. First, we demonstrate that a driven transverse-field Ising model can be used to engineer complex interactions which enable the emulation of an equilibrium SPT phase. This phase remains stable only within a parametric time scale controlled by the driving frequency, beyond which its topological features break down. To overcome this issue, we consider an alternate route based upon realizing an intrinsically Floquet SPT phase that does not have any equilibrium analog...
September 22, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29340455/central-venous-catheter-related-infections-in-patients-receiving-short-term-hemodialysis-therapy-incidence-associated-factors-and-microbiological-aspects
#3
Mayra Gonçalves Menegueti, Natália Cristina Betoni, Fernando Bellissimo-Rodrigues, Elen Almeida Romão
INTRODUCTION: Bloodstream infections are the second most common cause of death among patients on hemodialysis. This study aimed to evaluate the incidence of and risk factors associated with central venous catheter-related infections in patients undergoing hemodialysis, and to identify and characterize the type and antimicrobial susceptibility profiles of the primary microorganisms isolated during one year of follow-up. METHODS: A prospective cohort study was conducted in 2014 in a hemodialysis referral center...
November 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29339405/health-care-professionals-neckties-as-a-source-of-transmission-of-bacteria-to-patients-a-systematic-review
#4
Pia Pace-Asciak, Sanjiv K Bhimrao, Frederick K Kozak, Brian D Westerberg
BACKGROUND: There is growing concern that neckties worn by health care professionals may contribute to infections contracted in health care settings. We evaluated the evidence for health-care-associated infections resulting from neckties and whether the evidence is sufficient to warrant a tieless policy in Canada. METHODS: We performed a systematic review to determine whether neckties worn by health care professionals colonize harmful pathogenic bacteria and whether they contribute to the spread of infection to patients in the inpatient or outpatient setting...
January 12, 2018: CMAJ Open
https://www.readbyqxmd.com/read/29339349/jeremy-hunt-s-new-department-major-overhaul-or-window-dressing
#5
Gareth Iacobucci
No abstract text is available yet for this article.
January 16, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29339283/hydroxyethyl-cellulose-hydrogel-for-wound-dressing-fabrication-characterization-and-in-vitro-evaluation
#6
Gomaa F El Fawal, Marwa M Abu-Serie, Mohamed A Hassan, Mohamed S Elnouby
In this study, new hydrogel membranes were developed based on hydroxyethyl cellulose (HEC) supplemented with tungsten oxide for further implementing in wound treatment. HEC hydrogel membranes were fabricated and crosslinked using citric acid (CA). Various tests were carried out including FTIR, XRD, porosity measurements, swelling, mechanical properties, gel fraction, and thermal gravimetric analysis to evaluate the efficiency of the prepared membranes as wound dressing material. In addition, wound healing activity of the examined membranes for human dermal fibroblast cell line was investigated employing in vitro scratching model...
January 12, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29338227/entangled-photonic-nuclear-molecular-dynamics-of-lif-in-quantum-optical-cavities
#7
Johan F Triana, Daniel Pelaez Ruiz, Jose Luis Sanz-Vicario
The quantum photodynamics of a simple diatomic molecule with a permanent dipole immersed within an optical cavity containing a quantized radiation field is studied in detail. The chosen molecule under study, lithium fluoride (LiF), is characterized by the presence of an avoided crossing between the two lowest 11Σ potential energy curves (covalent-ionic diabatic crossing). Without field, after prompt excitation from the ground state 11Σ, the excited nuclear wave packet moves back and forth in the upper 21Σ state, but in the proximity of the avoided crossing, the non-adiabatic coupling transfers part of the nuclear wave packet to the lower 11Σ state, which eventually leads to dissociation...
January 16, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29337327/modulating-inflammation-in-a-cutaneous-chronic-wound-model-by-il-10-released-from-collagen-silica-nanocomposites-via-gene-delivery
#8
Xiaolin Wang, Thibaud Coradin, Christophe Hélary
Cutaneous chronic wounds remain a major clinical challenge which requires the development of novel wound dressings. Previously, we showed that collagen-silica nanocomposites consisting of polyethyleneimine (PEI)-DNA complexes associated with silica nanoparticles (SiNP), collagen hydrogel and 3T3 fibroblasts, can work as a local "cell factory". Indeed, the "in-gel" transfection leads to a sustained production and release of biomolecules. Herein, we further explored the possibility for nanocomposites to deliver interleukin-10 (IL-10), a potent anti-inflammatory cytokine, which favors tissue repair...
January 16, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29334612/tempo-oxidized-bacterial-cellulose-pellicle-with-silver-nanoparticles-for-wound-dressing
#9
Chun-Nan Wu, Shih-Chang Fuh, Shin-Ping Lin, Yen-Yi Lin, Hung-Yueh Chen, Jui-Ming Liu, Kuan-Chen Cheng
Biocompatible bacterial cellulose pellicle (BCP) is a candidate for biomedical material such as wound dressing. However, due to lack of antibacterial activity, to grant BCP with the property is crucial for its biomedical application. In the present study, BCP was modified by 2,2,6,6-tetramethylpiperidine-1-oxyl radical (TEMPO)-mediated oxidation using TEMPO/NaClO/NaBr system at pH 10 to form TEMPO-oxidized BCP (TOBCP) with anionic C6 carboxylate groups. The TOBCP was subsequently ion-exchanged in AgNO3 solution and silver nanoparticles (AgNP) with diameter of ~16...
January 15, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29334332/quantifying-lower-extremity-and-trunk-function-for-dressing-in-stroke-patients-a-retrospective-observational-study
#10
Takaaki Fujita, Atsushi Sato, Kazuaki Iokawa, Kazuhiro Yamane, Yuichi Yamamoto, Yoko Ohira, Koji Otsuki, Fusae Tozato
Background Dressing performance relates strongly with balance function, and it is mainly influenced by the motor functions of the affected and unaffected lower extremity and trunk function in stroke patients. For the remedial approach to be effective, ascertaining the degree of function needed in the affected and unaffected lower extremities and trunk to achieve balance function requisite for dressing is necessary. Objectives This study aimed to elucidate standards of lower extremity and trunk function necessary for stroke patients to gain balance requisite for dressing...
January 15, 2018: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/29334124/use-of-antiviral-medications-in-drug-reaction-with-eosinophilia-and-systemic-symptoms-dress-a-case-of-infantile-dress
#11
Maggie L Chow, David Kim, Sonia Kamath, David Peng, Minnelly Luu
A 3-month-old girl with Sturge-Weber syndrome presented with a morbilliform rash, eosinophilia, and fulminant liver failure to our tertiary pediatric hospital. She was diagnosed with drug reaction with eosinophilia and systemic symptoms complicated by viremia and evidence of viral hepatitis on liver biopsy. We discuss the role of viral reactivation in drug reaction with eosinophilia and systemic symptoms and the relevance of antiviral therapy in management.
January 15, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29333932/a-comparison-between-dacc-with-chlorhexidine-acetate-soaked-paraffin-gauze-and-foam-dressing-for-skin-graft-donor-sites
#12
Jun Won Lee, Seong Hoon Park, In Suck Suh, Hii Sun Jeong
OBJECTIVE: Retrograde infections often occur with excessive or incomplete drainage of exudate, or as a result of adherence of dressings to wounds. Dialkylcarbamoyl chloride (DACC) irreversibly binds to bacterial surfaces and physically removes bacteria when dressings are changed. Chlorhexidine acetate-soaked paraffin gauze provides a moist wound-healing environment. We hypothesise that when DACC is combined with chlorhexidine acetate-soaked paraffin gauze, wound healing times decrease...
January 2, 2018: Journal of Wound Care
https://www.readbyqxmd.com/read/29333931/hyperspectral-imaging-of-tissue-perfusion-and-oxygenation-in-wounds-assessing-the-impact-of-a-micro-capillary-dressing
#13
Thomas Wild, Markus Becker, Jochen Winter, Nicole Schuhschenk, Georg Daeschlein, Frank Siemers
OBJECTIVE: Experimental tests of non-invasive multi- or hyperspectral imaging (HSI) systems reveal the high potential of support for medical diagnostic purposes and scientific biomedical analysis. Until now the use of HSI technologies for medical applications was limited by complex and overly sophisticated systems. We present a new and compact HSI-camera that could be used in normal clinical practice. METHOD: We assessed the use of the HSI system on the hands of 10 healthy volunteers, looking at control parameters, and those following venous occlusion, arterial occlusion and reperfusion, including tissue oxygenation, tissue haemoglobin index, perfusion in 4-6mm depth=near infrared spectroscopy (NIR), and tissue water index...
January 2, 2018: Journal of Wound Care
https://www.readbyqxmd.com/read/29333930/a-histological-analysis-of-artificial-skin-in-an-extensively-burned-child-14-years-after-application-a-case-report
#14
Robert Zajicek, Eva Sticova, Radana Königova
INTRODUCTION: Artificial skin has become the treatment of choice in extensive, full-thickness thermal injuries. The longest follow-up of the healing process in burn sites covered with the Integra Bilayer Matrix Wound Dressing onto the wound published to date was at around five years after application. In our case report, we describe the clinical and histological analysis of an extensive, full-thickness thermal injury 14 years on from treatment with the bilayer matrix wound dressing. CASE STUDY: A nine-year-old boy suffered a full-thickness skin loss over 85% of his body surface area following a fire accident...
January 2, 2018: Journal of Wound Care
https://www.readbyqxmd.com/read/29333929/efficacy-of-an-imaging-device-at-identifying-the-presence-of-bacteria-in-wounds-at-a-plastic-surgery-outpatients-clinic
#15
Ellen L Blackshaw, Steven L A Jeffery
OBJECTIVE: Current standard diagnostic practice of bacterial infections by visual inspection under white light is subjective, and microbiological sampling is suboptimal due to high false negative rates and the lengthy time needed for culture results to arrive. The MolecuLight i:X Imaging Device attempts to combat the issues faced in standard practice by providing a non-contact, real-time method of visualising bacteria within wounds. Our aim was to test this imaging device in a series of patients...
January 2, 2018: Journal of Wound Care
https://www.readbyqxmd.com/read/29333738/antibacterial-and-antifungal-activity-of-poly-lactic-acid-bovine-lactoferrin-nanofiber-membranes
#16
Raul Machado, André da Costa, Dina M Silva, Andreia C Gomes, Margarida Casal, Vitor Sencadas
Antimicrobial materials have become relevant for local therapies preventing microbial resistance induced by systemic antibiotic treatments. This work reports the development of electrospun poly(lactic acid) (PLLA) nanofiber membranes loaded with bovine lactoferrin (bLF) up to 20 wt%. The membranes present smooth and nondefective fibers with mean diameters between 717 ± 197 and 495 ± 127 nm, and an overall porosity of ≈80%. The hydrophobicity of the PLLA membranes is reduced by the presence of bLF. The release profile of bLF correlates with an anomalous transport model, with 17...
January 15, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29333419/evaluation-of-a-polyurethane-foam-dressing-impregnated-with-3-povidone-iodine-betafoam-in-a-rat-wound-model
#17
Jin Won Lee, Kyo Young Song
Purpose: The purpose of this study was to evaluate the efficacy of Betafoam in terms of wound healing and safety. Methods: Fifty-four male adult Sprague-Dawley rats (weight, 200-250 g) were used in the study. Full-thickness skin defects were created on the back of each rats. The rats were assigned to 6 groups according to the type of wound dressing used (n = 9 for each group): Betafoam, Allevyn-Ag, Mepilex-Ag, Medifoam silver, Polymem-Ag, and gauze. The wound size, histological findings, and amount of DNA on the changed dressings for each group were analyzed and compared...
January 2018: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/29331783/comparative-study-of-novel-in-situ-decorated-porous-chitosan-selenium-scaffolds-and-porous-chitosan-silver-scaffolds-towards-antimicrobial-wound-dressing-application
#18
Dhee P Biswas, Neil M O'Brien-Simpson, Eric C Reynolds, Andrea J O'Connor, Phong A Tran
Dermal defects caused by trauma or disease are challenging to treat due to difficult-to-treat infections that impair wound healing. Due to the widespread emergence of drug-resistant bacteria and dwindling discoveries of new antibiotics, there is currently an urgent need to introduce novel antimicrobials effective against antibiotic-resistant bacteria without causing damage to host tissues. As selenium (Se) and silver (Ag) are known for their antimicrobial properties, we investigated the separate loading of these materials into porous chitosan/PVA (CS) scaffolds through a simple in situ deposition method to create two distinct wound dressing materials (CS-Se and CS-Ag)...
January 5, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29330848/cultured-allogeneic-fibroblast-injection-versus-fibroblasts-cultured-on-amniotic-membrane-scaffold-for-dystrophic-epidermolysis-bullosa-treatment
#19
H Moravvej, F Abdollahimajd, M-H Naseh, Z Piravar, E Abolhasani, N Mozafari, H Niknejad
BACKGROUND: Different methods of fibroblast application have been examined to treat recessive dystrophic epidermolysis bullosa (RDEB). OBJECTIVE: To compare the effects of intradermal injection of cultured allogeneic fibroblasts in healing RDEB wounds with that of fibroblasts seeded on amniotic membrane scaffolds (FAMS) or standard wound care (SWC) with Vaseline gauze as controls. MATERIALS &METHODS: Seven patients were recruited, and seven wounds were assessed in each patient: three wounds were treated with injection of intradermal fibroblasts, three were treated with FAMS, and one was dressed with SWC...
January 12, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29329542/relative-validity-of-a-web-based-food-frequency-questionnaire-for-danish-adolescents
#20
Anne A Bjerregaard, Thorhallur I Halldorsson, Freja B Kampmann, Sjurdur F Olsen, Inge Tetens
BACKGROUND: With increased focus on dietary intake among youth and risk of diseases later in life, it is of importance, prior to assessing diet-disease relationships, to examine the validity of the dietary assessment tool. This study's objective was to evaluate the relative validity of a self-administered web-based FFQ among Danish children aged 12 to 15 years. METHODS: From a nested sub-cohort within the Danish National Birth Cohort, 124 adolescents participated...
January 12, 2018: Nutrition Journal
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