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https://www.readbyqxmd.com/read/29908516/analysis-of-volatiles-in-fire-debris-by-combination-of-activated-charcoal-strips-acs-and-automated-thermal-desorption-gas-chromatography-mass-spectrometry-atd-gc-ms
#1
Marie Martin Fabritius, Alain Broillet, Stefan König, Wolfgang Weinmann
Adsorption of volatiles in gaseous phase to activated charcoal strip (ACS) is one possibility for the extraction and concentration of ignitable liquid residues (ILRs) from fire debris in arson investigations. Besides liquid extraction using carbon dioxide or hexane, automated thermo-desorption can be used to transfer adsorbed residues to direct analysis by gas chromatography-mass spectrometry (GC-MS). We present a fire debris analysis work-flow with headspace adsorption of volatiles onto ACS and subsequent automated thermo-desorption (ATD) GC-MS analysis...
June 4, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29908501/review-of-modelling-air-pollution-from-traffic-at-street-level-the-state-of-the-science
#2
REVIEW
H Forehead, N Huynh
Traffic emissions are a complex and variable cocktail of toxic chemicals. They are the major source of atmospheric pollution in the parts of cities where people live, commute and work. Reducing exposure requires information about the distribution and nature of emissions. Spatially and temporally detailed data are required, because both the rate of production and the composition of emissions vary significantly with time of day and with local changes in wind, traffic composition and flow. Increasing computer processing power means that models can accept highly detailed inputs of fleet, fuels and road networks...
June 13, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29908492/treatment-of-guillain-barr%C3%A3-syndrome-with-bifidobacterium-infantis-through-regulation-of-t-helper-cells-subsets
#3
Peng Shi, Hongdang Qu, Di Nian, Yuhua Chen, Xiaolin Liu, Qiang Li, Qianqian Li, Chun Wang, Ming Ye, Bo Ma
BACKGROUND: Guillain-Barré syndrome (GBS) is a rare, autoimmune-mediated disease. The use of Bifidobacterium is reportedly effective in alleviating GBS since they act by regulating T helper (Th) cells. OBJECTIVES: In this study, we explored the differentiation of T helper cell subsets in patients with GBS. We also evaluated the effect of GBS on Bifidobacterium levels in patients and the likely protective influence of this bacterium in alleviating the disease in an animal model...
June 13, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29908491/go-with-the-flow-or-solitary-confinement-a-look-inside-the-single-cell-toolbox-for-isolation-of-rare-and-uncultured-microbes
#4
REVIEW
Geert Rb Huys, Jeroen Raes
With the vast majority of the microbial world still considered unculturable or undiscovered, microbiologists not only require more fundamental insights concerning microbial growth requirements but also need to implement miniaturized, versatile and high-throughput technologies to upscale current microbial isolation strategies. In this respect, single-cell-based approaches are increasingly finding their way to the microbiology lab. A number of recent studies have demonstrated that analysis and separation of free microbial cells by flow-based sorting as well as physical stochastic confinement of individual cells in microenvironment compartments can facilitate the isolation of previously uncultured species and the discovery of novel microbial taxa...
June 13, 2018: Current Opinion in Microbiology
https://www.readbyqxmd.com/read/29908488/effect-of-dissolution-of-magnesium-alloy-az31-on-the-rheological-properties-of-phosphate-buffer-saline
#5
Usman Riaz, Leela Rakesh, Ishraq Shabib, Waseem Haider
The issue of long-term incompatible interactions associated with the permanent implants can be eliminated by using various biodegradable metal implants. The recent research is focusing on the use of degradable stents to restore most of the hindrances of capillaries, and coronary arteries by supplying instant blood flow with constant mechanical and structural support. However, internal endothelialization and infection due to the corrosion of implanted stents are not easy to diagnose in the long run. In the recent past, magnesium (Mg) has been widely investigated for the cardiovascular stent applications...
June 5, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29908468/first-report-on-the-pharmacokinetic-profile-of-nimbolide-a-novel-anticancer-agent-in-oral-and-intravenous-administrated-rats-by-lc-ms-method
#6
Shandilya Mahamuni Baira, Amit Khurana, Jaganmohan Somagoni, R Srinivas, Chandraiah Godugu, M V N Kumar Talluri
Nimbolide is a novel, natural compound with promising potential as a drug candidate for anticancer activity. It is isolated from the Indian traditional medicinal plant Azadirachta indica popularly known as neem. The present study was undertaken to explore the oral bioavailability and pharmacokinetic characteristics of nimbolide in rats using the LC/QTOF/MS method. A simple protein precipitation method using acetonitrile was employed for extracting nimbolide from rat plasma. The chromatographic separation of nimbolide and the internal standard (regorafenib) was attained on an Aquity BEH C18 column (100 × 2...
June 2, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29908465/anoxic-nitrogen-cycling-in-a-hydrocarbon-and-ammonium-contaminated-aquifer
#7
Naomi S Wells, Uwe Kappelmeyer, Kay Knöller
Nitrogen fate and transport through contaminated groundwater systems, where N is both ubiquitous and commonly limits pollutant attenuation, must be re-evaluated given evidence for new potential microbial N pathways. We addressed this by measuring the isotopic composition of dissolved inorganic N (DIN = NH4 + , NO2 - , and NO3 - ) and N functional gene abundances (amoA, nirK, nirS, hszA) from 20 to 38 wells across an NH4 + , hydrocarbon, and SO4 2- contaminated aquifer. In-situ N attenuation was confirmed on three sampling dates (0, +6, +12 months) by the decreased [DIN] (4300 - 40 μM) and increased δ15 N-DIN (5‰-33‰) over the flow path...
June 13, 2018: Water Research
https://www.readbyqxmd.com/read/29908462/study-of-the-influence-of-the-supersaturation-coefficient-on-scaling-rate-using-the-pre-calcified-surface-of-a-quartz-crystal-microbalance
#8
Hélène Cheap-Charpentier, Olivier Horner, Jean Lédion, Hubert Perrot
Scale deposition is a common issue in industrial plants, which creates technical problems, i.e. reduction of heat transfer, decrease of flow rate due to an obstruction of pipes. Therefore, the development of some appropriate methods based on well suitable in situ sensors to evaluate and predict the scaling propensity of water is a major concern in current research. This would be a good strategy for the optimization of anti-scaling treatments. In this study, scaling tests were carried out using a sensitive sensor, which has been developed using a quartz crystal microbalance with a pre-calcified electrode surface (SQCM)...
May 29, 2018: Water Research
https://www.readbyqxmd.com/read/29908441/synthesis-and-biological-evaluation-of-new-coumarins-bearing-2-4-diaminothiazole-5-carbonyl-moiety
#9
Adileh Ayati, Tayebeh Oghabi Bakhshaiesh, Setareh Moghimi, Rezvan Esmaeili, Keivan Majidzadeh-A, Maliheh Safavi, Loghman Firoozpour, Saeed Emami, Alireza Foroumadi
A series of new coumarin-containing compounds 3a-l and 4a-c was designed and synthesized based on the chalcone-type 4-amino-5-cinnamoylthiazole scaffold 2, and screened for their in vitro anticancer and antioxidant activities. Representatively, the 2-thiomorpholinothiazole derivative 3k with IC50 values of 7.5-16.9 μg/ml demonstrated good cytotoxic effects against tested cell lines MCF-7, HepG2 and SW480. Further investigation by flow cytometric analysis confirmed that this compound induces apoptotic cell death in MCF-7 cells and cause G1-phase arrest in the cell cycle...
June 7, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29908395/a-novel-compliance-pressure-loop-approach-to-quantify-arterial-compliance-in-systole-and-in-diastole
#10
Mehmet Kaya, Vignesh Balasubramanian, Amit Patel, Yueya Ge, John K-J Li
Arterial compliance has been recognized as a critical parameter in governing pulsatile flow dynamics. It has traditionally been assumed constant throughout the cardiac cycle and its computation has been based either on the classic Windkessel model (C) in diastole or the stroke volume over pulse pressure (Cv ) method in systole. Other methods using area (Cam ) or two-area (Ctam ) and exponential (C(P)exp1 ) methods were used for the cardiac cycle. We proposed a novel compliance-pressure loop (CPP loop) approach for the quantification of arterial compliance and compared it to existing linear and nonlinear methods...
June 5, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29908332/enhanced-nanoparticle-uptake-into-virus-infected-cells-could-nanoparticles-be-useful-in-antiviral-therapy
#11
Yasmin Abo-Zeid, Richard A Urbanowicz, Brian J Thomson, William L Irving, Alexander W Tarr, Martin C Garnett
Virus infections cause diseases of different severity ranged from mild infection e.g. common cold into life threating diseases e.g. Human Immunodeficiency virus (HIV), Hepatitis B. Virus infections represent 44% of newly emerging infections. Although there are many efficient antiviral agents, they still have drawbacks due to accumulation at off target organs and developing of virus resistance due to virus mutation. Therefore, developing a delivery system that can selectively target drug into affected organs and avoid off target accumulation would be a highly advantageous strategy to improve antiviral therapy...
June 13, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29908253/a-microbiological-assessment-of-sterile-surgical-helmet-systems-using-particle-counts-and-culture-plates-recommendations-for-safe-use-whilst-scrubbing
#12
T S Moores, S A Khan, B D Chatterton, G Harvey, S C Lewthwaite
BACKGROUND: Infection occurs in 2-4% of arthroplasty cases, identifying potential sources of infection can help to reduce infection rates. The aim of this study was to identify the impact and potential for contamination of our hands and gowns whilst scrubbing using sterile surgical helmet systems (SSHS). METHOD: A colony-forming unit (CFU) is a pathogenic particle of 0.5 to 5 micrometres. A standard arthroplasty hood and a SSHS with and without the fan on for a 3-minute exposure to represent scrubbing time, were tested on 3 subjects and a mannequin with concurrent particle counts and culture plates...
June 13, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29908250/immunochromatographic-test-for-rapid-serological-diagnosis-of-human-angiostrongyliasis
#13
Praphathip Eamsobhana, Anchalee Tungtrongchitr, Darawan Wanachiwanawin, Hoi-Sen Yong
OBJECTIVES: The serological diagnosis of human infection with Angiostrongylus cantonensis remains problematic because there are no commercially available validated tests. Most laboratories use domestically prepared tests such as the enzyme-linked immunosorbent assay (ELISA) or immunoblotting. Since laboratory facilities are not always available in endemic areas, we developed and assessed a rapid lateral flow immunochromatographic assay (AcQuickDx Test) to detect anti-A. cantonensis antibodies in human serum...
June 13, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29908229/mir-1297-suppresses-pancreatic-cancer-cell-proliferation-and-metastasis-by-targeting-mtdh
#14
Zili Chen, Yifei Ma, Yaozhen Pan, Haitao Zhu, Chao Yu, Chengyi Sun
Dysregulation of miR-1297 has been detected in various human cancers, and miR-1297 can function as either an oncogene or tumor suppressor. However, the role of miR-1297 in pancreatic adenocarcinoma has not been previously reported. Here, we investigated miR-1297 expression in pancreatic cancer and the role it plays in the development and metastasis of pancreatic adenocarcinoma. In the present study, MiR-1297 and metadherin (MTDH) expression in pancreatic cancer tissue was detected using quantitative real-time PCR (qRT-PCR) and western blot methods...
June 13, 2018: Molecular and Cellular Probes
https://www.readbyqxmd.com/read/29908086/innate-immune-response-reflects-disease-activity-in-eosinophilic-granulomatosis-with-polyangiitis
#15
Naomi Tsurikisawa, Chiyako Oshikata, Maiko Watanabe, Takahiro Tsuburai, Takeshi Kaneko, Hiroshi Saito
BACKGROUND: Eosinophilic granulomatosis with polyangiitis (EGPA) is a disease characterized by allergic granulomatosis, necrotizing vasculitis, and peripheral blood eosinophilia. Interleukin (IL)-33, thymic stromal lymphopoietin (TSLP), and type-2 innate lymphoid cells (ILC2) are involved in the innate and type-2 immune responses in EGPA. However, the relationships among these molecules and the mechanisms underlying the development of EGPA remain unknown. OBJECTIVE: We investigated the relationships among peripheral blood eosinophil count, serum IL-33 and TSLP concentration, and peripheral blood ILC2 count in patients with EGPA, chronic eosinophilic pneumonia (CEP), or bronchial asthma (BA)...
June 16, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29908049/imaging-sublingual-microcirculatory-perfusion-in-pediatric-patients-receiving-procedural-sedation-with-propofol-a-pilot-study
#16
M A Riedijk, D M J Milstein
OBJECTIVE: Procedural sedation with propofol is widely used in the pediatric population. A well-known side effect of propofol is a decrease of peripheral vascular resistance resulting in hypotension, but little is known about the effects on the microcirculation in humans. We aimed to evaluate the effects of propofol on the sublingual microcirculatory perfusion by continuous video imaging in pediatric patients undergoing procedural sedation. METHODS: Patients admitted to the Pediatric Intensive Care Unit for procedural sedation were recruited...
June 16, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29908041/automated-quantification-of-microvascular-perfusion
#17
P Mason McClatchey, Nicholas A Mignemi, Zhengang Xu, Ian M Williams, Jane E B Reusch, Owen P McGuinness, David H Wasserman
OBJECTIVE: Changes in microvascular perfusion have been reported in many diseases, yet the functional significance of altered perfusion is often difficult to determine. This is partly because commonly used techniques for perfusion measurement often rely on either indirect or by-hand approaches. METHODS: We developed and validated a fully automated software technique to measure microvascular perfusion in videos acquired by fluorescence microscopy in the mouse gastrocnemius...
June 16, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29908029/fc%C3%AE-ri-fc%C3%AE-rii-and-il-10-as-predictive-biomarkers-for-post-therapeutic-cicatrization-time-in-monocytes-from-cutaneous-leishmaniasis-patients
#18
Marina L Rodrigues-Alves, Otoni A O Melo-Júnior, Jordana G Coelho-Dos-Reis, Marcelo A Pascoal-Xavier, Heloisa Alves-Costa, Clovis A Reis, Walderez O Dutra, Rosiana E Silva, Maria C R Senna, Andreia C Faria, Nayara I Medeiros, Juliana A S Gomes, Denise Silveira-Lemos, Olindo A Martins-Filho, Andréa Teixeira-Carvalho, Matheus F Costa-Silva, Rodolfo C Giunchetti, Vanessa Peruhype-Magalhães
Cutaneous Leishmaniasis (CL) treatment is based on therapy with Glucantime® , yet there are few laboratory methods to monitor its success. In this study, ex vivo and in vitro evaluations of peripheral blood monocytes were performed in a longitudinal study to characterize the impact of Glucantime® on overall phenotypic/functional features of these cells from CL patients to identify predictive biomarkers for post-therapeutic monitoring by flow cytometry. The ex vivo evaluation from CL patients demonstrated a modulatory profile before treatment, with a decrease in TLR-2, FcγRII, HLA-DR, CD86, IFN-γR, TNF, IL-12, NO, and an increase in FcγRIII and IL-10R...
June 16, 2018: Parasite Immunology
https://www.readbyqxmd.com/read/29907889/gis-assessment-of-the-risk-of-gene-flow-from-brassica-napus-to-its-wild-relatives-in-china
#19
Jing-Jing Dong, Ming-Gang Zhang, Wei Wei, Ke-Ping Ma, Ying-Hao Wang
Risk of gene flow from canola (Brassica napus) to species of wild relatives was used as an example to evaluate the risk of gene flow of transgenic crops. B. juncea and B. rapa were the most common weedy Brassica species in China, which were both sexually compatible with canola. Data on canola cultivation in China were collected and analyzed using geographic information system (GIS), and the distribution of its wild relatives was predicted by MaxEnt species distribution model. Based on biological and phenological evidence, our results showed that gene flow risk exists in most parts of the country, especially in places with higher richness of wild Brassica species...
June 16, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29907849/does-prolonged-severe-hypercapnia-interfere-with-normal-cerebrovascular-function-in-piglets
#20
Massroor Pourcyrous, Sandeep Chilakala, Mohamad T Elabiad, Helena Parfenova, Charles W Leffler
BACKGROUND: Hypercapnia causes cerebral vasodilation and increased cerebral blood flow (CBF). During prolonged hypercapnia it is unknown whether cerebral vasodilation persists and whether cerebrovascular function is preserved. We investigated the effects of prolonged severe hypercapnia on pial arteriolar diameters (PAD) and cerebrovascular reactivity to vasodilators and vasoconstrictors. METHODS: Piglets were anesthetized, intubated and ventilated. Closed cranial windows were implanted to measure PAD...
May 28, 2018: Pediatric Research
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