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https://www.readbyqxmd.com/read/28227867/knife-edge-scanning-microscopy-for-in-silico-study-of-cerebral-blood-flow-from-biological-imaging-data-to-flow-simulations
#1
Michael R Nowak, Alexander Lozovskiy, Dimitri Dobroskok, Yoonsuck Choe, Michael R Nowak, Alexander Lozovskiy, Dimitri Dobroskok, Yoonsuck Choe, Dimitri Dobroskok, Michael R Nowak, Alexander Lozovskiy, Yoonsuck Choe
Knife-edge scanning microscopy provides the capability to image whole-brain cerebral microvasculature of small organisms, such as mice, at sub-micron resolution, providing a feasible foundation for the reconstruction of circulatory pathways from the systemic to cellular scale. In this paper, we illustrate the feasibility of using this data to model cerebral blood flow using numerical simulations. Starting with a small vascular element in microcirculation of interest, we present its segmentation from the imaging-data volume, construction of its triangular surface mesh, assembly of its tetrahedral volumetric mesh from the surface, and then conclude with Stokes flow simulation of plasma through the microvascular vessel...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227866/modelling-nutrient-transfer-based-on-3d-imaging-of-the-human-placental-microstructure
#2
S Perazzolo, R M Lewis, B G Sengers, S Perazzolo, R M Lewis, B G Sengers, B G Sengers, R M Lewis, S Perazzolo
Impaired transfer of nutrients from mother to fetus can affect pregnancy outcomes. The placenta has a complex microstructure, including the maternal intervillous space and fetal capillaries. Previous computational models of placental transfer either assumed a simplified idealized local geometry or were based on 2D imaging. In this study, we present a novel 3D computational model to assess the placental transfer of nutrients at the microscale in interaction with the maternal flow environment. A stack of confocal microscopy images of the placental terminal villi was collected and reconstructed...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227794/a-numerical-and-experimental-study-of-acoustic-micromixing-in-3d-microchannels-for-lab-on-a-chip-devices
#3
Susana O Catarino, Vania C Pinto, Paulo J Sousa, Rui Lima, Joao M Miranda, Graca Minas, Susana O Catarino, Vania C Pinto, Paulo J Sousa, Rui Lima, Joao M Miranda, Graca Minas, Joao M Miranda, Paulo J Sousa, Susana O Catarino, Rui Lima, Vania C Pinto, Graca Minas
This paper reports a numerical and experimental study of acoustic streaming and micromixing in polydimethylsiloxane microchannels. The mixing between two fluids flowing in microchannels was evaluated through the following conditions: (1) using a 28 μm thick β-poly(vinylidene fluoride) (β-PVDF) as a piezoelectric transducer actuated with a 24 Vpp and 40 MHz sinusoidal voltage; (2) using different flow rates. The results suggest that the mixing length increases as the flow rate increases and that the acoustic streaming phenomenon leads to a reduction on the mixing length...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227692/current-distribution-in-tissues-with-conducted-electrical-weapons-operated-in-drive-stun-mode
#4
Dorin Panescu, Mark W Kroll, Michael Brave, Dorin Panescu, Mark W Kroll, Michael Brave, Dorin Panescu, Mark W Kroll, Michael Brave
INTRODUCTION: The TASER® conducted electrical weapon (CEW) is best known for delivering electrical pulses that can temporarily incapacitate subjects by overriding normal motor control. The alternative drive-stun mode is less understood and the goal of this paper is to analyze the distribution of currents in tissues when the CEW is operated in this mode. METHODS AND RESULTS: Finite element modeling (FEM) was used to approximate current density in tissues with boundary electrical sources placed 40 mm apart...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227682/development-of-ocular-viscosity-characterization-method
#5
Shu-Hao Lu, Guo-Zhen Chen, Stanley Y Y Leung, David C C Lam, Shu-Hao Lu, Guo-Zhen Chen, Stanley Y Y Leung, David C C Lam, David C C Lam, Shu-Hao Lu, Guo-Zhen Chen, Stanley Y Y Leung
Glaucoma is the second leading cause for blindness. Irreversible and progressive optic nerve damage results when the intraocular pressure (IOP) exceeds 21 mmHg. The elevated IOP is attributed to blocked fluid drainage from the eye. Methods to measure the IOP are widely available, but methods to measure the viscous response to blocked drainage has yet been developed. An indentation method to characterize the ocular flow is developed in this study. Analysis of the load-relaxation data from indentation tests on drainage-controlled porcine eyes showed that the blocked drainage is correlated with increases in ocular viscosity...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227680/a-mobile-platform-for-automated-screening-of-asthma-and-chronic-obstructive-pulmonary-disease
#6
Daniel B Chamberlain, Rahul Kodgule, Richard Ribon Fletcher, Daniel B Chamberlain, Rahul Kodgule, Richard Ribon Fletcher, Daniel B Chamberlain, Richard Ribon Fletcher, Rahul Kodgule
Chronic Obstructive Pulmonary Disease (COPD) and asthma each represent a large proportion of the global disease burden; COPD is the third leading cause of death worldwide and asthma is one of the most prevalent chronic diseases, afflicting over 300 million people. Much of this burden is concentrated in the developing world, where patients lack access to physicians trained in the diagnosis of pulmonary disease. As a result, these patients experience high rates of underdiagnosis and misdiagnosis. To address this need, we present a mobile platform capable of screening for Asthma and COPD...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227671/imquant-an-image-based-fluorescence-reader-for-quantitative-lateral-flow-immunoassays
#7
Kaushik Basak Chowdhury, Jayaraj Joseph, Jayaraman Kiruthi Vasan, Mohanasankar Sivaprakasam, Kaushik Basak Chowdhury, Jayaraj Joseph, Jayaraman Kiruthi Vasan, Mohanasankar Sivaprakasam, Jayaraman Kiruthi Vasan, Mohanasankar Sivaprakasam, Jayaraj Joseph, Kaushik Basak Chowdhury
Fluorescence immunoassays (FIA) have strong potential in enabling rapid quantitative immunological testing at point of care. Existing state of the art instruments employ laser scanning of FIA test kits, which require the use of electromechanical systems, making the instrument bulky, heavy and less reliable in the long term. There is a growing need for an extremely compact and reliable, motion-free, automated reader for accurate quantification of immunoassays. Here, we present ImQuant, an image based FIA reader with integrated monochromatic excitation source, optical filtering and real time image capture, assisted with an intuitive graphical user interface...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227638/simulation-of-fluid-environment-using-a-robotic-orthosis-on-human-lower-extremity-for-therapeutic-purposes
#8
Tayfun Efe Ertop, Tolga Yuksel, Erhan Ilhan Konukseven, Tayfun Efe Ertop, Tolga Yuksel, Erhan Ilhan Konukseven, Tolga Yuksel, Erhan Ilhan Konukseven, Tayfun Efe Ertop
Rehabilitation under water is a viable physical rehabilitation option, but it has some limitations in terms of adapting to needs of each patient. In addition, its facility requirements are relatively high. Simulating the fluid environment using a robotic system would enable therapists adjust various parameters so that the therapy is tailored to the patient's unique state. Also, using a robotic system instead might be less costly and easily reachable. In this study, human lower extremity movement in fluids is modeled...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227509/development-of-a-brain-monitoring-system-for-multimodality-investigation-in-awake-rats
#9
Kanokwan Limnuson, Raj K Narayan, Amrit Chiluwal, Chad Bouton, Ping Wang, Chunyan Li, Kanokwan Limnuson, Raj K Narayan, Amrit Chiluwal, Chad Bouton, Ping Wang, Chunyan Li, Chunyan Li, Ping Wang, Kanokwan Limnuson, Amrit Chiluwal, Raj K Narayan, Chad Bouton
Multimodal brain monitoring is an important approach to gain insight into brain function, modulation, and pathology. We have developed a unique micromachined neural probe capable of real-time continuous monitoring of multiple physiological, biochemical and electrophysiological variables. However, to date, it has only been used in anesthetized animals due to a lack of an appropriate interface for awake animals. We have developed a versatile headstage for recording the small neural signal and bridging the sensors to the remote sensing units for multimodal brain monitoring in awake rats...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227467/a-simplified-state-space-model-of-biventricular-assist-device-cardiovascular-system-interaction
#10
Vivian C A Koh, Einly Lim, Boon Chiang Ng, Yong Kuen Ho, Nigel H Lovell, Vivian C A Koh, Einly Lim, Boon Chiang Ng, Yong Kuen Ho, Nigel H Lovell, Boon Chiang Ng, Einly Lim, Vivian C A Koh, Nigel H Lovell, Yong Kuen Ho
A simplified state-space model of biventricular assist device (BiVAD)-cardiovascular system (CVS) interaction is presented. The state-space equations includes a six-compartments CVS model incorporating the ventricles, the pulmonary and systemic circulations as well as the non-linear behavior of the valve flow, together with a left ventricular assist device (LVAD) and a right ventricular assist device (RVAD) component. The left and right pump speeds serve as the input variables for the state-space model. The model is simulated with three operational modes, i...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227465/reaction-mechanism-of-blood-coagulation-factors-in-shear-flow-field
#11
Koki Kawakami, Daisuke Sakota, Ryo Kosaka, Masahiro Nishida, Yasuo Kawaguchi, Osamu Maruyama, Koki Kawakami, Daisuke Sakota, Ryo Kosaka, Masahiro Nishida, Yasuo Kawaguchi, Osamu Maruyama, Masahiro Nishida, Koki Kawakami, Ryo Kosaka, Yasuo Kawaguchi, Osamu Maruyama, Daisuke Sakota
Thrombus formation in blood pumps is a major problem. It has been reported that the shear rate is closely related to thrombus formation in blood pumps; however, the mechanism of blood coagulation in a shear flow field is not yet fully understood. The purpose of this study is to evaluate the effect of shear loading on the reaction of blood coagulation factors quantitatively. Human blood and porcine blood were used as test blood and sheared at 2,880 s(-1) for 3 h using a rheometer. After shear loading to the test blood, the activated partial thromboplastin time (APTT) and prothrombin time (PT) of sample plasma were measured using an automated coagulation analyzer...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227463/hemodynamic-effects-of-synchronizing-an-intra-aortic-vad-in-reverse-rotation-control-with-left-ventricle-a-mock-loop-study
#12
Yaxin Wang, P Alex Smith, Daniel L Timms, Po-Lin Hsu, Richard A McMahon, Yaxin Wang, P Alex Smith, Daniel L Timms, Po-Lin Hsu, Richard A McMahon, Richard A McMahon, Daniel L Timms, Po-Lin Hsu, Yaxin Wang, P Alex Smith
The IntraVAD is an intra-aortic left ventricular assist device (LVAD) to be located in the ascending aorta. In order to enhance unloading and promote coronary flow for the left ventricle (LV), an operating mechanism, reverse-rotation control (RRc) mode, has been developed for the IntraVAD and tested in vitro in a mock circulation loop (MCL). The RRc mode consists of forward rotation (FR) and reverse rotation (RR). The synchronization between the IntraVAD and the LV was studied to offload the ventricle more effectively and to improve myocardial perfusion...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227461/dynamic-modeling-of-apnea-induced-concurrent-variations-in-arterial-blood-pressure-and-cerebral-blood-flow-velocity
#13
Raichel Alex, Rong Zhang, Donald E Watenpaugh, Khosrow Behbehani, Raichel Alex, Rong Zhang, Donald E Watenpaugh, Khosrow Behbehani, Raichel Alex, Rong Zhang, Khosrow Behbehani, Donald E Watenpaugh
Obstructive Sleep Apnea (OSA) is characterized by partial (hypopnea) or complete cessation (apnea) of airflow to the lungs during sleep. It has been previously reported that apnea episodes lead to significant rise in instantaneous blood pressure concomitant with a rise in cerebral blood flow velocity, indicating loss of cerebral autoregulation during the episodes. In this study, we have used Auto Regressive Moving Average model (ARMA (na, nb, nk)) to quantify OSA induced dynamic changes in cerebral blood flow velocity (CBFV) with beat to beat blood pressure (BP) as an input...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227460/a-study-of-apnea-induced-covariations-of-cerebral-blood-flow-and-exhaled-co2
#14
Varun Kanal, Raichel Alex, Nazaneen Mousavi, Kevin Jepsen, Donald E Watenpaugh, Rong Zhang, Khosrow Behbehani, Varun Kanal, Raichel Alex, Nazaneen Mousavi, Kevin Jepsen, Donald E Watenpaugh, Rong Zhang, Khosrow Behbehani, Raichel Alex, Rong Zhang, Khosrow Behbehani, Donald E Watenpaugh, Kevin Jepsen, Varun Kanal, Nazaneen Mousavi
Sleep apnea is identified by repetitive reduction or complete cessation of breathing during sleep. Sleep apnea affects cerebral hemodynamics and it is important to study this effect. Measuring cerebral blood flow during sleep is challenging due to the need to maintain a contact between the flow probe and the skull. It is hypothesized that there exists a relationship between the variations in the exhaled CO2 and Cerebral Blood Flow during sleep apnea. To test this hypothesis, the present study was conducted in two parts: simulated and nocturnal sleep study...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227459/leg-fluid-accumulation-during-prolonged-sitting
#15
Daniel Vena, Jonathan Rubianto, Milos Popovic, Azadeh Yadollahi, Daniel Vena, Jonathan Rubianto, Milos Popovic, Azadeh Yadollahi, Daniel Vena, Azadeh Yadollahi, Jonathan Rubianto, Milos Popovic
The accumulation of fluid in the legs due to sedentariness can be a health risk in extreme cases. Negative health impacts associated with leg fluid accumulation include leg edema and risk of blood clots. Furthermore, fluid accumulating in the legs is accompanied by fluid shift into the upper body which is also associated with health risks such as: increased blood pressure when lying down, respiratory problems in people with heart failure, and increased sleep apnea. Understanding the pattern by which fluid accumulates in the legs can aid in the development of devices for reducing leg fluid accumulation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227457/evaluation-of-periodic-breathing-in-respiratory-flow-signal-of-elderly-patients-using-svm-and-linear-discriminant-analysis
#16
Sara Argerich, Sergio Herrera, Salvador Benito, Beatriz F Giraldo, Sara Argerich, Sergio Herrera, Salvador Benito, Beatriz F Giraldo, Beatriz F Giraldo, Salvador Benito, Sara Argerich, Sergio Herrera
Aging population is a major concern that is reflected in the increase of chronic diseases. Heart Failure (HF) is one of the most common chronic diseases of elderly people that is punctuated with acute episodes, which result in hospitalization. The periodic modulation of the amplitude of the breathing pattern is proved to be one of the multiple symptoms of an acute episode, and thus, the features extracted from its characterization contribute in the improvement of the first diagnosis of the clinical practice...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227452/single-source-photoplethysmograph-transducer-for-local-pulse-wave-velocity-measurement
#17
P M Nabeel, Jayaraj Joseph, Vartika Awasthi, Mohanasankar Sivaprakasam, P M Nabeel, Jayaraj Joseph, Vartika Awasthi, Mohanasankar Sivaprakasam, P M Nabeel, Mohanasankar Sivaprakasam, Vartika Awasthi, Jayaraj Joseph
Cuffless evaluation of arterial blood pressure (BP) using pulse wave velocity (PWV) has received attraction over the years. Local PWV based techniques for cuffless BP measurement has more potential in accurate estimation of BP parameters. In this work, we present the design and experimental validation of a novel single-source Photoplethysmograph (PPG) transducer for arterial blood pulse detection and cycle-to-cycle local PWV measurement. The ability of the transducer to continuously measure local PWV was verified using arterial flow phantom as well as by conducting an in-vivo study on 17 volunteers...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227444/novel-3d-coaxial-flow-focusing-nozzle-device-for-the-production-of-monodispersed-collagen-microspheres
#18
Sravani Jaligama, Po-Jung Huang, Jun Kameoka, Sravani Jaligama, Po-Jung Huang, Jun Kameoka, Jun Kameoka, Sravani Jaligama, Po-Jung Huang
We have developed a 3D coaxial flow-focusing nozzle device for the mass production of monodispersed collagen microspheres and chemically crosslinked them using EDC (1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide) and N-hydroxysuccinimide (NHS). The size of the microspheres was varied between 200 μm and 600 μm by adjusting the ratio of the flow rates of the dispersed and continuous phases. MDA231-GFP cells were attached to the surface of these particles and their viability was investigated. Because they are comprised of a natural biomaterial, these collagen microspheres will have numerous applications, including bone regeneration scaffolds for tissue engineering and analyses of cancer cell interactions in a 3D environment...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227415/ultrasound-transducer-positioning-aid-for-fetal-heart-rate-monitoring
#19
Paul Hamelmann, Alex Kolen, Lars Schmitt, Rik Vullings, Hans van Assen, Massimo Mischi, Libertario Demi, Judith van Laar, Jan Bergmans, Paul Hamelmann, Alex Kolen, Lars Schmitt, Rik Vullings, Hans van Assen, Massimo Mischi, Libertario Demi, Judith van Laar, Jan Bergmans, Alex Kolen, Judith Van Laar, Paul Hamelmann, Libertario Demi, Lars Schmitt, Rik Vullings, Hans Van Assen, Massimo Mischi, Jan Bergmans
Fetal heart rate (fHR) monitoring is usually performed by Doppler ultrasound (US) techniques. For reliable fHR measurements it is required that the fetal heart is located within the US beam. In clinical practice, clinicians palpate the maternal abdomen to identify the fetal presentation and then the US transducer is fixated on the maternal abdomen where the best fHR signal can be obtained. Finding the optimal transducer position is done by listening to the strength of the Doppler audio output and relying on a signal quality indicator of the cardiotocographic (CTG) measurement system...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227411/source-imaging-of-simple-finger-movements-captured-during-auditory-response-tasks-using-space-time-frequency-based-sparsity-constraints
#20
Aritra Chaudhuri, Aurobinda Routray, Aritra Chaudhuri, Aurobinda Routray, Aurobinda Routray, Aritra Chaudhuri
Neural Information Flow during simple cognitive or motor actions is a significant research topic; one of which is a simple finger movement. In this paper, Electro-encephalograph (EEG) Source Imaging has been used to model the Neural Information flow, during performance of a simple Auditory Response Task (ART), specifically by employment of a space-time-frequency sparsity constrained based algorithm, namely, Spatio-temporal Unifying Tomography (STOUT). The estimated sources are then studied according to location defined based on Destrieux atlas...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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