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https://www.readbyqxmd.com/read/28320179/multimodal-and-simultaneous-assessments-of-brain-and-spinal-fluid-abnormalities-in-chronic-fatigue-syndrome-and-the-effects-of-psychiatric-comorbidity
#1
Benjamin H Natelson, Xiangling Mao, Aaron J Stegner, Gudrun Lange, Diana Vu, Michelle Blate, Guoxin Kang, Eli Soto, Tolga Kapusuz, Dikoma C Shungu
The purpose of this study was to investigate whether CFS patients without comorbid psychiatric diagnoses differ from CFS patients with comorbid psychiatric diagnoses and healthy control subjects in neuropsychological performance, the proportion with elevated spinal fluid protein or white cell counts, cerebral blood flow (CBF), brain ventricular lactate and cortical glutathione (GSH). The results of the study did not show any differences in any of the outcome measures between CFS patients with and without psychiatric comorbidity, thus indicating that psychiatric status may not be an exacerbating factor in CFS...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28320141/functional-magnetic-resonance-imaging-responses-in-cadasil
#2
Ikreet Cheema, Aaron R Switzer, Cheryl R McCreary, Michael D Hill, Richard Frayne, Bradley G Goodyear, Eric E Smith
OBJECTIVES: The magnitude of the blood oxygen dependent level (BOLD) functional MRI (fMRI) response to visual stimulation is reduced in the small vessel disease cerebral amyloid angiopathy (CAA), reflecting impaired vascular reactivity. We determined whether BOLD responses were reduced in another small vessel disease, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). METHODS: BOLD fMRI data were collected using a visual stimulus (contrast-reversing checkerboard) and motor task (finger-tapping)...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28320134/post-hemorrhagic-hydrocephalus-recent-advances-and-new-therapeutic-insights
#3
REVIEW
Qianwei Chen, Zhou Feng, Qiang Tan, Jing Guo, Jun Tang, Liang Tan, Hua Feng, Zhi Chen
Post-hemorrhagic hydrocephalus (PHH), also referred to as progressive ventricular dilatation, is caused by disturbances in cerebrospinal fluid (CSF) flow or absorption following hemorrhage in the brain. As one of the most serious complications of neonatal/adult intraventricular hemorrhage (IVH), subarachnoid hemorrhage (SAH), and traumatic brain injury (TBI), PHH is associated with increased morbidity and disability of these events. Common sequelae of PHH include neurocognitive impairment, motor dysfunction, and growth impairment...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28320094/lncrna-meg3-had-anti-cancer-effects-to-suppress-pancreatic-cancer-activity
#4
Lei Gu, Jiaqiang Zhang, Minmin Shi, Qian Zhan, Baiyong Shen, Chenghong Peng
AIM: The aim of this study was to explain the mechanism of lncRNA MEG 3 in pancreatic cancer. METHODS: We were collecting 30 pancreatic cancer patients, taking the sample from these patients. We measured the PI3K protein expressions from 30 patients by IHC and WB methods and MEG 3 expression by RT-PCR, and analyzed the relationship between PI3K protein expression and pancreatic cancer patients' clinical pathology and the correlation between lncRNA MEG 3 and PI3K...
March 16, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28320092/inhibition-of-pi3k-akt-mtor-signaling-pathway-promotes-autophagy-of-articular-chondrocytes-and-attenuates-inflammatory-response-in-rats-with-osteoarthritis
#5
Jian-Feng Xue, Zhong-Min Shi, Jian Zou, Xiao-Lin Li
OBJECTIVE: This study aims to explore the relationship between PI3K/AKT/mTOR signaling pathway and autophagy of articular chondrocytes in rats with osteoarthritis (OA). METHODS: Rat articular chondrocytes were isolated and cultured, and then induced by protein inhibitors of PI3K/AKT/mTOR signaling pathway. Chondrocytes were assigned into blank group, IL-1β induction group (IL-1β group), PI3K inhibitor+IL-1β induction group (PI3Ki+IL-1β group), AKT inhibitor+IL-1β induction group (AKTi+IL-1β group) and mTOR inhibitor+IL-1β induction group (mTORi+IL-1β group)...
March 16, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28320083/xiaoaiping-combined-with-cisplatin-can-inhibit-proliferation-and-invasion-and-induce-cell-cycle-arrest-and-apoptosis-in-human-ovarian-cancer-cell-lines
#6
Ai-Wen Zheng, Ya-Qing Chen, Jing Fang, Ying-Li Zhang, Dong-Dong Jia
PURPOSE: The aim of the present study was utilizing Xiaoaiping as a single agent or combined with cisplatin to study its effect on the ovarian cancer cells (HO-8910 and HO-8910PM cells) in tumor cell proliferation, cell apoptosis, cell cycle distribution and cell invasion and migration. METHODS: Both HO-8910 and HO-8910PM cell lines were treated with Xiaoaiping injection, cisplatin or combination. Effects on the cell viability and apoptosis induction were estimated using the Cell counting Kit-8 assay and Annexin V-FITC/Propidium Iodide staining...
March 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28320030/changes-in-regulatory-t-cell-levels-in-acute-cerebral-ischemia
#7
Xuerui Pang, Weidong Qian
Background Acute stroke causes intense and significant changes in the immune system as well as in the number and the ratio of various immune cells. Material and Methods Several large-scale studies have shown that ischemic stroke leaves the human body in a state of immunodepression. The regulatory T (Treg) cells may be strongly associated with a change of immune status. In this trial, we collected venous blood from a cohort of patients who were diagnosed with acute ischemic stroke within the last 24 hours (n = 139)...
March 20, 2017: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/28319908/the-sociology-of-space-as-a-catalyst-for-innovation-in-the-health-sector
#8
Trust Saidi, Katusha de Villiers, Tania S Douglas
This paper reviews the role of space in facilitating innovation. It draws on the sociology of space in exploring the social practices, institutional forces and material complexity of how people and spaces interact. We assess how space influences the development of innovative solutions to challenges in the health sector. Our aim is to advance an understanding of the social production of space for healthcare innovation. We draw empirical examples from the Innovation Hub at Groote Schuur Hospital in Cape Town to illustrate that innovation does not take place in an institutional vacuum, but requires space that facilitates interaction of different players...
March 9, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28319888/heterogeneous-reaction-of-peroxyacetyl-nitrate-pan-on-soot
#9
Ximeng Zhao, Tianyu Gao, Jianbo Zhang
The interaction between photochemical oxidants and aerosol particles has been examined in previous atmospheric pollution studies. The heterogeneous reaction can affect the concentration of gases and free radicals, as well as the morphology and properties of particles. In this report, the interaction between the photochemical oxidant peroxyacetyl nitrate (PAN) and soot particles was investigated using a flow tube system. We used real-time online monitoring equipment to track changes in PAN concentrations. Substances on the soot surface were detected using ion chromatography (IC), x-ray photoelectron spectroscopy (XPS), and other surface analysis methods...
March 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/28319861/different-salt-concentrations-induce-alterations-both-in-photosynthetic-parameters-and-salt-gland-activity-in-leaves-of-the-mangrove-avicennia-schaueriana
#10
Janaina Dos Santos Garcia, Ândrea Carla Dalmolin, Marcel Giovanni Costa França, Pedro Antônio Oliveira Mangabeira
Mangrove sites are constantly under tidal regimes, where there is variation of dissolved oxygen and saline content in water. This study evaluated the effects of varying salinity in Avicennia schaueriana, an abundant species in the sea-mangrove-river interface. Seedlings of A. schaueriana were harvested at the riverbank and placed in different saline and nutrient solutions in a greenhouse in order to simulate a saline flow. After 7 acclimatization days, plants were exposed to the following saline concentrations: 0, 50, 170 and 250mM NaCl, for a period of 30 days...
March 16, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28319844/a-comparative-study-of-casson-fluid-with-homogeneous-heterogeneous-reactions
#11
Muhammad Ijaz Khan, Muhammad Waqas, Tasawar Hayat, Ahmed Alsaedi
Magnetohydrodynamic (MHD) stagnation point flow of Casson fluid towards a stretching sheet is addressed. Homogeneous-heterogeneous reactions together with homogeneous heat effect subject to a resistive force of electromagnetic origin is discussed. It is assumed that the homogeneous process in the ambient fluid is governed by first order kinetics and the heterogeneous process on the wall surface is given by isothermal cubic autocatalator kinetics. Ordinary differential systems have been considered. Solutions of the problems are presented via a numerical technique namely built in shooting method...
March 9, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28319830/anti-proliferative-effect-of-metformin-on-a-feline-injection-site-sarcoma-cell-line-independent-of-mtor-inhibition
#12
J Pierro, C Saba, K McLean, R Williams, E Karpuzoglu, R Prater, K Hoover, R Gogal
Metformin is an oral hypoglycemic drug that has been shown to inhibit cancer cell proliferation via up-regulation of AMPK (AMP-activated protein kinase), and possibly inhibition of mTOR (mammalian target of rapamycin). The purpose of this study was to evaluate the effects of metformin on a feline injection site sarcoma cell line. Cells from a feline injection site sarcoma cell line were treated with metformin at varied concentrations. A dose-dependent decrease in cell viability following metformin treatment was observed, with an IC50 of 8...
March 6, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28319827/immunophenotypical-characterization-of-canine-mesenchymal-stem-cells-from-perivisceral-and-subcutaneous-adipose-tissue-by-a-species-specific-panel-of-antibodies
#13
Ana Ivanovska, Stefano Grolli, Paolo Borghetti, Francesca Ravanetti, Virna Conti, Elena De Angelis, Francesca Macchi, Roberto Ramoni, Paolo Martelli, Ferdinando Gazza, Antonio Cacchioli
Immunophenotypical characterization of mesenchymal stem cells is fundamental for the design and execution of sound experimental and clinical studies. The scarce availability of species-specific antibodies for canine antigens has hampered the immunophenotypical characterization of canine mesenchymal stem cells (MSC). The aim of this study was to select a panel of species-specific direct antibodies readily useful for canine mesenchymal stem cells characterization. They were isolated from perivisceral and subcutaneous adipose tissue samples collected during regular surgeries from 8 dogs...
February 27, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28319767/potential-for-thermochemical-conversion-of-biomass-residues-from-the-integrated-sugar-ethanol-process-fate-of-ash-and-ash-forming-elements
#14
Meheretu Jaleta Dirbeba, Anders Brink, Nikolai DeMartini, Maria Zevenhoven, Mikko Hupa
In this work, potential for thermochemical conversion of biomass residues from an integrated sugar-ethanol process and the fate of ash and ash-forming elements in the process are presented. Ash, ash-forming elements, and energy flows in the process were determined using mass balances and analyses of eight different biomass samples for ash contents, elemental compositions, and heating values. The results show that the ash content increases from the sugarcane to the final residue, vinasse. The cane straw, which is left in the field, contains one-third of the energy and 25% of the K and Cl while the vinasse contains 2% of the energy and 40% of the K and Cl in the cane...
March 6, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28319750/unfavorable-effect-of-levetiracetam-on-cultured-hippocampal-neurons-after-hyperthermic-injury
#15
Krzysztof Sendrowski, Piotr Sobaniec, Elżbieta Poskrobko, Małgorzata Rusak, Wojciech Sobaniec
BACKGROUND: The aim of this study was to examine the viability of neurons and the putative neuroprotective effects of second-generation antiepileptic drug, levetiracetam (LEV), on cultured hippocampal neurons injured by hyperthermia. METHODS: Primary cultures of rat's hippocampal neurons at 7day in vitro (DIV) were incubated in the presence or absence of LEV in varied concentrations under hyperthermic conditions. Cultures were heated in a temperature of 40°C for 24h or in a temperature of 41°C for 6h...
January 24, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28319745/characteristics-and-proteomic-analysis-of-pyrene-degradation-by-brevibacillus-brevis-in-liquid-medium
#16
Kun Wei, Hua Yin, Hui Peng, Zehua Liu, Guining Lu, Zhi Dang
Polycyclic aromatic hydrocarbons (PAHs) are widely spread in various ecosystems and are of great concern due to their potential toxicity, mutagenicity and carcinogenicity. Bioremediation has been proposed as an effective approach to remove PAHs. In this study, the physiological responses and proteome of Brevibacillus brevis under exposure to pyrene, a four-ring compound from PAHs family, were investigated. The changes of cell viability of B. brevis were observed during the degradation of pyrene by means of flow cytometry...
March 14, 2017: Chemosphere
https://www.readbyqxmd.com/read/28319744/kinetics-and-mechanism-of-17%C3%AE-estradiol-chlorination-in-a-pilot-scale-water-distribution-systems
#17
Cong Li, Feilong Dong, John C Crittenden, Feng Luo, Xinbo Chen, Taotao Zhao
The kinetics and mechanisms of 17β-estradiol (E2) chlorination in water distribution systems (WDS) were studied. We examined the impacts of different factors, including pH, temperature, humic acid concentration and type, and flow velocity. The experimental results showed that the rate constants in beaker tests and WDS were described by a pseudo-first-order model. pH had the greatest impact on E2 chlorination in the beaker tests. However, temperature had the greatest impact on E2 chlorination in WDS. Mechanistic analysis of E2 chlorination showed that chlorine attacked E2 in three stages: 1) halogenation of the aromatic ring, 2) cleavage of the benzene moiety and chlorine or bromine substitution formation, and 3) formation of trihalomethanes (THMs) and halogenated acetic acids (HAAs) from phenolic intermediates through benzene ring opening with chlorine and/or bromine substitution of hydrogen on the carbon atoms...
March 14, 2017: Chemosphere
https://www.readbyqxmd.com/read/28319707/treatment-of-anaerobic-digested-effluent-in-biochar-packed-vertical-flow-constructed-wetland-columns-role-of-media-and-tidal-operation
#18
Simon Kizito, Tao Lv, Shubiao Wu, Zeeshan Ajmal, Hongzhen Luo, Renjie Dong
Three types of vertical flow constructed wetland columns (VFCWs), packed with corn cob biochar (CB-CW), wood biochar (WB-CW) and gravel (G-CW) under tidal flow operations, were comparatively evaluated to investigate anaerobic digested effluent treatment performance and mechanisms. It was demonstrated that CB-CW and WB-CW provide significantly higher removal efficiencies for organic matter (>59%), NH4(+)-N (>76%), TN (>37%) and phosphorus (>71%), compared with G-CW (22%-49%). The higher pollutants removal ability of biochar-packed VFCWs was mainly attribute to the higher adsorption ability and microbial cultivation in the porous biochar media...
March 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28319701/tracking-effluent-discharges-in-undisturbed-stony-soil-and-alluvial-gravel-aquifer-using-synthetic-dna-tracers
#19
Liping Pang, Beth Robson, Kata Farkas, Erin McGill, Arvind Varsani, Lea Gillot, Jinhua Li, Phillip Abraham
With the intensification of human activities, fresh water resources are increasingly being exposed to contamination from effluent disposal to land. Thus, there is a greater need to identify the sources and pathways of water contamination to enable the development of better mitigation strategies. To track discharges of domestic effluent into soil and groundwater, 10 synthetic double-stranded DNA (dsDNA)(3) tracers were developed in this study. Laboratory column experiment and field groundwater and soil lysimeter studies were carried out spiking DNA with oxidation-pond domestic effluent...
March 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28319684/what-do-we-do-with-what-we-learn-statistical-learning-of-orthographic-regularities-impacts-written-word-processing
#20
Fabienne Chetail
Individuals rapidly become sensitive to recurrent patterns present in the environment and this occurs in many situations. However, evidence of a role for statistical learning of orthographic regularities in reading is mixed, and its role has peripheral status in current theories of visual word recognition. Additionally, exactly which regularities readers learn to be sensitive to is still unclear. To address these two issues, three experiments were conducted with artificial scripts. In Experiments 1a and 1b, participants were exposed to a flow of artificial words (five characters) for a few minutes, with either two or four bigrams occurring very frequently...
March 16, 2017: Cognition
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