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https://www.readbyqxmd.com/read/29456725/application-of-deep-learning-to-the-classification-of-images-from-colposcopy
#1
Masakazu Sato, Koji Horie, Aki Hara, Yuichiro Miyamoto, Kazuko Kurihara, Kensuke Tomio, Harushige Yokota
The objective of the present study was to investigate whether deep learning could be applied successfully to the classification of images from colposcopy. For this purpose, a total of 158 patients who underwent conization were enrolled, and medical records and data from the gynecological oncology database were retrospectively reviewed. Deep learning was performed with the Keras neural network and TensorFlow libraries. Using preoperative images from colposcopy as the input data and deep learning technology, the patients were classified into three groups [severe dysplasia, carcinoma in situ (CIS) and invasive cancer (IC)]...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29445924/correction-to-the-use-of-pipac-pressurized-intraperitoneal-aerosol-chemotherapy-in-gynecological-oncology-a-statement-by-the-arbeitsgemeinschaft-gynaekologische-onkologie-ago-kommission-ovar-ago-study-group-north-eastern-german-society-of-gynaecologic-oncology
#2
A M Dueckelmann, D Fink, P Harter, V Heinzelmann, C Marth, M Mueller, A Reinthaller, K Tamussino, P Wimberger, J Sehouli
The title of the article has been published incorrectly. The correct title is given below.
February 14, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29411193/-paraneoplastic-cerebellar-degeneration-pcd-%C3%A2-an-interdisciplinary-challenge-in-neurology-oncology-and-palliative-care
#3
Sabine Burger, Stefan Lorenzl
Paraneoplastic neurological syndromes describe a very heterogeneous group of neurological disorders. Paraneoplastic cerebellar degeneration is frequently associated with gynecological tumors, lung cancer and Hodgkin lymphoma. The following case report shows the typical course of this disease as well as the diagnostic and therapeutic challenges. Furthermore the importance of interdisciplinary cooperation between neurology, oncology and palliative care for prognosis and symptom stabilization is highlighted.
February 6, 2018: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29363631/human-immunodeficiency-virus-seroprevalence-in-patients-with-invasive-cervical-cancer-in-zaria-north-western-nigeria
#4
Adamu Abdullahi, Muhammad Inuwa Mustapha, Dawotola Ayorinde David, Olasinde Tajudeen Ayodeji
BACKGROUND: Cervical cancer is the commonest gynecological malignancy in our environment and is an Acquired Immuno-Deficiency Syndrome (AIDS)-associated malignancy. Documented data on the Human Immune-deficiency Virus (HIV) seroprevalence among patients with cervical cancer in our environment are scarce. OBJECTIVE: The aim of this study is to determine the prevalence of HIV infection in women with cancer of the cervix. STUDY DESIGN: The work is a descriptive survey by design, concentrating in frequency of occurrences of prevalence of the dissease in either cases for a number of years retrospectively carried out at the Radiotherapy and Oncology Centre of Ahmadu Bello University Teaching Hospital (ABUTH) Zaria...
January 2018: Annals of African Medicine
https://www.readbyqxmd.com/read/29353371/a-systematic-assessment-of-google-search-queries-and-readability-of-online-gynecologic-oncology-patient-education-materials
#5
Alexandra Martin, J Ryan Stewart, Jeremy Gaskins, Erin Medlin
The Internet is a major source of health information for gynecologic cancer patients. In this study, we systematically explore common Google search terms related to gynecologic cancer and calculate readability of top resulting websites. We used Google AdWords Keyword Planner to generate a list of commonly searched keywords related to gynecologic oncology, which were sorted into five groups (cervical cancer, ovarian cancer, uterine cancer, vulvar cancer, vaginal cancer) using five patient education websites from sgo...
January 20, 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/29339300/robotic-surgery-in-elderly-and-very-elderly-gynecologic-cancer-patients
#6
Valerio Gallotta, Carmine Conte, Marco D'Indinosante, Alex Federico, Antonella Biscione, Giuseppe Vizzielli, Carolina Bottoni, Maria Vittoria Carbone, Francesco Legge, Stefano Uccella, Pierpaolo Ciocchetti, Andrea Russo, Lorenzo Polidori, Giovanni Scambia, Gabriella Ferrandina
STUDY OBJECTIVE: To investigate feasibility, safety and short-term outcomes of robotic surgery (RS) for gynecological oncologic indications (cervical, endometrial and ovarian cancer) in elderly patients, especially women aged from 65 to 74 (Elderly group - EG), compared to women ≥ 75 (Very Elderly group - VEG). DESIGN: Retrospective cohort study (Canadian Task Force classification II-2). SETTING: Catholic University of the Sacred Hearth, Rome, Italy...
January 12, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29324533/multicenter-clinicopathological-study-of-high-grade-serous-carcinoma-presenting-as-primary-peritoneal-carcinoma
#7
Shinichi Komiyama, Yoshihiro Nishijima, Haruhiro Kondo, Hiroyuki Nomura, Satoshi Yamaguchi, Masayuki Futagami, Hiroharu Arai, Yoshihito Yokoyama, Nao Suzuki, Mikio Mikami, Kaneyuki Kubushiro, Daisuke Aoki, Yasuhiro Udagawa, Ryuichiro Nishimura
OBJECTIVE: We conducted a multicenter clinicopathological study to characterize patients with high-grade serous carcinoma presenting as primary peritoneal carcinoma (clinical PPC). METHODS: At 9 sites in Japan, patients with clinical PPC diagnosed according to Gynecologic Oncology Group criteria were enrolled retrospectively. The Gynecologic Oncology Group criteria allow for minor ovarian involvement by high-grade serous carcinoma. There was no systematic detailed histopathological review of the fallopian tubes to determine whether they were involved by serous carcinoma...
January 12, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29285310/role-of-preoperative-magnetic-resonance-imaging-and-histological-assessment-in-identifying-patients-with-a-low-risk-of-endometrial-cancer-a-korean-gynecologic-oncology-group-ancillary-study
#8
Jung-Yun Lee, Yun Hwan Kim, Jong-Min Lee, Kidong Kim, Sokbom Kang, Myong Cheol Lim, Beob-Jong Kim, Bang Hyun Lee, Jae Weon Kim
Preoperative identification of individuals at low risk of lymph node metastasis is key to the proper management of endometrial cancer. This study evaluated the role of preoperative assessment based on magnetic resonance imaging (MRI) and histological analysis in identifying a group having a low risk of lymph node metastasis. Data of 529 patients with endometrial cancer were obtained from a prospective multicenter database, between January 2012 and December 2014. Clinical staging, based on MRI and histological analysis, was compared with final pathology results after the surgical staging procedure...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29280313/efficacy-and-safety-of-oxycodone-naloxone-as-add-on-therapy-to-gabapentin-or-pregabalin-for-the-management-of-chemotherapy-induced-peripheral-neuropathy-in-korea
#9
Bong-Seog Kim, Jong-Youl Jin, Jung Hye Kwon, In Sook Woo, Yoon Ho Ko, Suk-Young Park, Hye-Jeong Park, Jin Hyung Kang
AIMS: To investigate the efficacy and safety of oxycodone/naloxone in patients with chemotherapy-induced peripheral neuropathy (CIPN) inadequately controlled with pregabalin or gabapentin. METHODS: This 4-week, multicenter, interventional, single-arm phase IV study included 72 Korean patients with CIPN inadequately controlled with pregabalin or gabapentin (Numeric Rating Scale 0-10; NRS ≥4 at baseline). In addition to pregabalin or gabapentin at existing doses, patients received 20/10 mg/day oxycodone/naloxone (up-titrated to 80/40 mg/day as needed)...
December 27, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29279661/setting-benchmarks-for-the-new-user-training-on-the-robotic-simulator
#10
Shayan M Dioun, Nicole D Fleming, Mark F Munsell, Joseph Lee, Pedro T Ramirez, Pamela T Soliman
Background and Objectives: Data showing the impact of the robotic simulator on fellowship training are limited. This study was conducted to determine whether simulator scores reflect the experience of the robotic gynecologic surgeon and to develop a simulator curriculum for trainees in gynecologic oncology. Methods: All faculty and fellows in the Department of Gynecologic Oncology and Reproductive Medicine were asked to participate. For phase 1, all participants were divided into 2 groups based on robotic surgical experience: beginner (0-50 cases) and experienced (>50 cases)...
October 2017: JSLS: Journal of the Society of Laparoendoscopic Surgeons
https://www.readbyqxmd.com/read/29244993/cervical-cancer-in-the-greater-accra-and-ashanti-regions-of-ghana
#11
Yvonne Nartey, Philip C Hill, Kwabena Amo-Antwi, Kofi M Nyarko, Joel Yarney, Brian Cox
Purpose Cervical cancer is a common cancer among women worldwide. An estimated 528,000 new cases and 266,000 deaths occurred in 2012. More than 85% of invasive cervical cancer cases occur in low- and middle-income countries. Cervical cancer ranks as the most common cancer among women in Ghana. We conducted a retrospective study to assess the descriptive epidemiology of cervical cancer in Ghana. We describe cervical cancer incidence and mortality rates for the regions served by two large hospitals in Ghana. Patients and Methods Information for women diagnosed with invasive cervical cancer between 2010 and 2013 was collected from the Komfo Anokye and Korle Bu Teaching Hospitals through review of medical, computer, and pathology records at the oncology units and the obstetrics and gynecology departments...
December 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/29232471/cytoreductive-surgery-for-ovarian-cancer-quality-assessment
#12
A H Brand, P A DiSilvestro, J Sehouli, J S Berek
Surgery is the cornerstone of treatment of ovarian cancer. Given the importance of achieving no or minimal macroscopic residual disease at primary surgery, performing an assessment of the quality of ovarian cancer surgery is crucial. Assessing the quality of care and surgical outcome allows us to establish baseline information, set standards of care and clear priorities, enable benchmarking against peers, and sustain quality improvement. We know that suboptimal care exists and variation in outcomes results...
November 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29212614/clinical-trials-in-gynecologic-oncology-past-present-and-future
#13
REVIEW
Christina M Annunziata, Elise C Kohn
The Gynecologic Oncology Group has historically performed ground-breaking, practice-changing clinical trials in women's cancers. The current standard of care for initial treatment of ovarian, endometrial, cervical, and trophoblastic cancers was determined by clinical trials completed within this cooperative group structure. For example, trial GOG-0111 set the standard for combining platinum and taxane chemotherapy in ovarian cancer, and more recently GOG-0240 provided evidence for adding bevacizumab to chemotherapy for women with advanced cervical cancer...
December 3, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29211304/risk-of-recurrence-prognosis-and-follow-up-for-danish-women-with-cervical-cancer-in-2005-2013-a-national-cohort-study
#14
Gry Assam Taarnhøj, Ib Jarle Christensen, Henrik Lajer, Katrine Fuglsang, Mette Moustgaard Jeppesen, Henriette Strøm Kahr, Claus Høgdall
BACKGROUND: In developed countries, women attend follow-up after treatment for cervical cancer to detect recurrence. The aim of this study was to describe the Danish population of women with early-stage cervical cancer at risk for recurrence and death due to recurrence. METHODS: Data were extracted from 3 nationwide databases to find women diagnosed with stage 1A1 to 1B1 cervical cancer in 2005-2013. Recurrences were determined from data on oncological or surgical treatment more than 3 months after the initial diagnosis and were cross-checked with patient journals...
December 6, 2017: Cancer
https://www.readbyqxmd.com/read/29200010/role-of-systematic-lymphadenectomy-to-tailor-adjuvant-therapy-in-early-endometrial-cancer
#15
Vivek Nama, Amit Patel, Lisa Kirk, John Murdoch, Joanne Bailey
OBJECTIVE: The long-standing protocol at our center for apparent stage I and II endometrial cancers comprises hysterectomy and bilateral salpingo-oophorectomy without lymphadenectomy. Adjuvant treatment is based in line with Postoperative Radiation Therapy in Endometrial Carcinoma 1 protocol. Our aim was to quantify the number of patients who would avoid external beam radiation therapy (EBRT) in our institution if we adopted a protocol of lymphadenectomy to tailor adjuvant EBRT and its impact on cost and quality of life...
January 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29195926/clinicopathologic-characteristics-associated-with-long-term-survival-in-advanced-epithelial-ovarian-cancer-an-nrg-oncology-gynecologic-oncology-group-ancillary-data-study
#16
C A Hamilton, A Miller, Y Casablanca, N S Horowitz, B Rungruang, T C Krivak, S D Richard, N Rodriguez, M J Birrer, F J Backes, M A Geller, M Quinn, M J Goodheart, D G Mutch, J J Kavanagh, G L Maxwell, M A Bookman
OBJECTIVE: To identify clinicopathologic factors associated with 10-year overall survival in epithelial ovarian cancer (EOC) and primary peritoneal cancer (PPC), and to develop a predictive model identifying long-term survivors. METHODS: Demographic, surgical, and clinicopathologic data were abstracted from GOG 182 records. The association between clinical variables and long-term survival (LTS) (>10years) was assessed using multivariable regression analysis. Bootstrap methods were used to develop predictive models from known prognostic clinical factors and predictive accuracy was quantified using optimism-adjusted area under the receiver operating characteristic curve (AUC)...
November 28, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29191972/mutations-in-homologous-recombination-genes-and-outcomes-in-ovarian-carcinoma-patients-in-gog-218-an-nrg-oncology-gynecologic-oncology-group-study
#17
Barbara M Norquist, Mark F Brady, Maria I Harrell, Tom Walsh, Ming K Lee, Suleyman Gulsuner, Sarah S Bernards, Silvia Casadei, Robert A Burger, Krishnansu S Tewari, Floor J Backes, Robert S Mannel, Gretchen Glaser, Cheryl Bailey, Stephen C Rubin, John T Soper, Heather A Lankes, Nilsa C Ramirez, Mary-Claire King, Michael J Birrer, Elizabeth M Swisher
PURPOSE: We hypothesized that mutations in homologous recombination repair (HRR) genes beyond BRCA1 and BRCA2 improve outcomes for ovarian carcinoma (OC) patients treated with platinum therapy and would impact the relative benefit of adding prolonged bevacizumab.  Experimental Design: We sequenced DNA from blood and/or neoplasm from 1,195 women enrolled in GOG-0218, a randomized phase III trial in advanced OC of bevacizumab added to carboplatin and paclitaxel. Defects in HRR were defined as damaging mutations in 16 genes...
November 30, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29185901/identification-of-distant-metastatic-disease-in-uterine-cervical-and-endometrial-cancers-with-fdg-pet-ct-analysis-from-the-acrin-6671-gog-0233-multicenter-trial
#18
Michael S Gee, Mostafa Atri, Andriy I Bandos, Robert S Mannel, Michael A Gold, Susanna I Lee
Purpose To assess the accuracy of staging positron emission tomography (PET)/computed tomography (CT) in detecting distant metastasis in patients with local-regionally advanced cervical and high-risk endometrial cancer in the clinical trial by the American College of Radiology Imaging Network (ACRIN) and the Gynecology Oncology Group (GOG) (ACRIN 6671/GOG 0233) and to compare central and institutional reader performance. Materials and Methods In this prospective multicenter trial, PET/CT and clinical data were reviewed for patients enrolled in ACRIN 6671/GOG 0233...
November 29, 2017: Radiology
https://www.readbyqxmd.com/read/29185270/impact-of-lymph-node-ratio-on-survival-in-stage-iii-ovarian-high-grade-serous-cancer-a-turkish-gynecologic-oncology-group-study
#19
Ali Ayhan, Nazlı Topfedaisi Ozkan, Mustafa Erkan Sarı, Husnu Celik, Murat Dede, Özgür Akbayır, Kemal Güngördük, Hanifi Şahin, Ali Haberal, Tayfun Güngör, Macit Arvas, Mehmet Mutlu Meydanlı
OBJECTIVE: The purpose of this study was to investigate the prognostic value of lymph node ratio (LNR) in patients with stage III ovarian high-grade serous carcinoma (HGSC). METHODS: A multicenter, retrospective department database review was performed to identify patients with ovarian HGSC at 6 gynecologic oncology centers in Turkey. A total of 229 node-positive women with stage III ovarian HGSC who had undergone maximal or optimal cytoreductive surgery plus systematic lymphadenectomy followed by paclitaxel plus carboplatin combination chemotherapy were included...
January 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29185267/baseline-risk-of-recurrence-in-stage-i-ii-endometrial-carcinoma
#20
Shinsuke Sasada, Mayu Yunokawa, Yae Takehara, Mitsuya Ishikawa, Shunichi Ikeda, Tomoyasu Kato, Kenji Tamura
OBJECTIVE: Though there are no evidences that postoperative therapy improves overall survival (OS) in stage I-II endometrial carcinoma, many women receive postoperative radiation or chemotherapy. This study aimed to investigate the baseline risk of recurrence after complete resection without any adjuvant therapies and to suppose the validity of postoperative therapy for stage I-II endometrial carcinoma. METHODS: Charts for patients with stage I-II endometrial carcinoma who underwent operation without postoperative therapy between January 2005 and December 2011 were retrospectively reviewed and the baseline risk of recurrence and prognosis were assessed...
January 2018: Journal of Gynecologic Oncology
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