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https://www.readbyqxmd.com/read/29232471/cytoreductive-surgery-for-ovarian-cancer-quality-assessment
#1
A H Brand, P A DiSilvestro, J Sehouli, J S Berek
Surgery is the cornerstone of treatment of ovarian cancer. Given the importance of achieving no or minimal macroscopic residual disease at primary surgery, performing an assessment of the quality of ovarian cancer surgery is crucial. Assessing the quality of care and surgical outcome allows us to establish baseline information, set standards of care and clear priorities, enable benchmarking against peers, and sustain quality improvement. We know that suboptimal care exists and variation in outcomes results...
November 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29212614/clinical-trials-in-gynecologic-oncology-past-present-and-future
#2
REVIEW
Christina M Annunziata, Elise C Kohn
The Gynecologic Oncology Group has historically performed ground-breaking, practice-changing clinical trials in women's cancers. The current standard of care for initial treatment of ovarian, endometrial, cervical, and trophoblastic cancers was determined by clinical trials completed within this cooperative group structure. For example, trial GOG-0111 set the standard for combining platinum and taxane chemotherapy in ovarian cancer, and more recently GOG-0240 provided evidence for adding bevacizumab to chemotherapy for women with advanced cervical cancer...
December 3, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29211304/risk-of-recurrence-prognosis-and-follow-up-for-danish-women-with-cervical-cancer-in-2005-2013-a-national-cohort-study
#3
Gry Assam Taarnhøj, Ib Jarle Christensen, Henrik Lajer, Katrine Fuglsang, Mette Moustgaard Jeppesen, Henriette Strøm Kahr, Claus Høgdall
BACKGROUND: In developed countries, women attend follow-up after treatment for cervical cancer to detect recurrence. The aim of this study was to describe the Danish population of women with early-stage cervical cancer at risk for recurrence and death due to recurrence. METHODS: Data were extracted from 3 nationwide databases to find women diagnosed with stage 1A1 to 1B1 cervical cancer in 2005-2013. Recurrences were determined from data on oncological or surgical treatment more than 3 months after the initial diagnosis and were cross-checked with patient journals...
December 6, 2017: Cancer
https://www.readbyqxmd.com/read/29200010/role-of-systematic-lymphadenectomy-to-tailor-adjuvant-therapy-in-early-endometrial-cancer
#4
Vivek Nama, Amit Patel, Lisa Kirk, John Murdoch, Joanne Bailey
OBJECTIVE: The long-standing protocol at our center for apparent stage I and II endometrial cancers comprises hysterectomy and bilateral salpingo-oophorectomy without lymphad-enectomy. Adjuvant treatment is based in line with Postoperative Radiation Therapy in Endometrial Carcinoma 1 protocol. Our aim was to quantify the number of patients who would avoid external beam radiation therapy (EBRT) in our institution if we adopted a protocol of lymphadenectomy to tailor adjuvant EBRT and its impact on cost and quality of life...
December 1, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29195926/clinicopathologic-characteristics-associated-with-long-term-survival-in-advanced-epithelial-ovarian-cancer-an-nrg-oncology-gynecologic-oncology-group-ancillary-data-study
#5
C A Hamilton, A Miller, Y Casablanca, N S Horowitz, B Rungruang, T C Krivak, S D Richard, N Rodriguez, M J Birrer, F J Backes, M A Geller, M Quinn, M J Goodheart, D G Mutch, J J Kavanagh, G L Maxwell, M A Bookman
OBJECTIVE: To identify clinicopathologic factors associated with 10-year overall survival in epithelial ovarian cancer (EOC) and primary peritoneal cancer (PPC), and to develop a predictive model identifying long-term survivors. METHODS: Demographic, surgical, and clinicopathologic data were abstracted from GOG 182 records. The association between clinical variables and long-term survival (LTS) (>10years) was assessed using multivariable regression analysis. Bootstrap methods were used to develop predictive models from known prognostic clinical factors and predictive accuracy was quantified using optimism-adjusted area under the receiver operating characteristic curve (AUC)...
November 28, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29191972/mutations-in-homologous-recombination-genes-and-outcomes-in-ovarian-carcinoma-patients-in-gog-218-an-nrg-oncology-gynecologic-oncology-group-study
#6
Barbara M Norquist, Mark F Brady, Maria I Harrell, Tom Walsh, Ming K Lee, Suleyman Gulsuner, Sarah S Bernards, Silvia Casadei, Robert A Burger, Krishnansu S Tewari, Floor J Backes, Robert S Mannel, Gretchen Glaser, Cheryl Bailey, Stephen C Rubin, John T Soper, Heather A Lankes, Nilsa C Ramirez, Mary-Claire King, Michael J Birrer, Elizabeth M Swisher
PURPOSE: We hypothesized that mutations in homologous recombination repair (HRR) genes beyond BRCA1 and BRCA2 improve outcomes for ovarian carcinoma (OC) patients treated with platinum therapy and would impact the relative benefit of adding prolonged bevacizumab.  Experimental Design: We sequenced DNA from blood and/or neoplasm from 1,195 women enrolled in GOG-0218, a randomized phase III trial in advanced OC of bevacizumab added to carboplatin and paclitaxel. Defects in HRR were defined as damaging mutations in 16 genes...
November 30, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29185901/identification-of-distant-metastatic-disease-in-uterine-cervical-and-endometrial-cancers-with-fdg-pet-ct-analysis-from-the-acrin-6671-gog-0233-multicenter-trial
#7
Michael S Gee, Mostafa Atri, Andriy I Bandos, Robert S Mannel, Michael A Gold, Susanna I Lee
Purpose To assess the accuracy of staging positron emission tomography (PET)/computed tomography (CT) in detecting distant metastasis in patients with local-regionally advanced cervical and high-risk endometrial cancer in the clinical trial by the American College of Radiology Imaging Network (ACRIN) and the Gynecology Oncology Group (GOG) (ACRIN 6671/GOG 0233) and to compare central and institutional reader performance. Materials and Methods In this prospective multicenter trial, PET/CT and clinical data were reviewed for patients enrolled in ACRIN 6671/GOG 0233...
November 29, 2017: Radiology
https://www.readbyqxmd.com/read/29185270/impact-of-lymph-node-ratio-on-survival-in-stage-iii-ovarian-high-grade-serous-cancer-a-turkish-gynecologic-oncology-group-study
#8
Ali Ayhan, Nazlı Topfedaisi Ozkan, Mustafa Erkan Sarı, Husnu Celik, Murat Dede, Özgür Akbayır, Kemal Güngördük, Hanifi Şahin, Ali Haberal, Tayfun Güngör, Macit Arvas, Mehmet Mutlu Meydanlı
OBJECTIVE: The purpose of this study was to investigate the prognostic value of lymph node ratio (LNR) in patients with stage III ovarian high-grade serous carcinoma (HGSC). METHODS: A multicenter, retrospective department database review was performed to identify patients with ovarian HGSC at 6 gynecologic oncology centers in Turkey. A total of 229 node-positive women with stage III ovarian HGSC who had undergone maximal or optimal cytoreductive surgery plus systematic lymphadenectomy followed by paclitaxel plus carboplatin combination chemotherapy were included...
January 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29185267/baseline-risk-of-recurrence-in-stage-i-ii-endometrial-carcinoma
#9
Shinsuke Sasada, Mayu Yunokawa, Yae Takehara, Mitsuya Ishikawa, Shunichi Ikeda, Tomoyasu Kato, Kenji Tamura
OBJECTIVE: Though there are no evidences that postoperative therapy improves overall survival (OS) in stage I-II endometrial carcinoma, many women receive postoperative radiation or chemotherapy. This study aimed to investigate the baseline risk of recurrence after complete resection without any adjuvant therapies and to suppose the validity of postoperative therapy for stage I-II endometrial carcinoma. METHODS: Charts for patients with stage I-II endometrial carcinoma who underwent operation without postoperative therapy between January 2005 and December 2011 were retrospectively reviewed and the baseline risk of recurrence and prognosis were assessed...
January 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29184441/potential-role-of-radiation-therapy-in-augmenting-the-activity-of-immunotherapy-for-gynecologic-cancers
#10
REVIEW
Christina H Son, Gini F Fleming, John W Moroney
Immune checkpoint inhibitors have become an area of intense interest in oncology and are actively being studied in a variety of cancer types with a wide range of success. In vitro data suggest mechanisms by which radiation can activate the immune system, and ongoing studies are exploring the potential interaction of checkpoint inhibitors with radiotherapy in both preclinical and clinical settings. Gynecologic malignancies are a heterogeneous group of tumors with varying prognoses, intrinsic immunogenicity, and potential for response to immune-based therapies...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/29174555/predictive-modeling-for-determination-of-microscopic-residual-disease-at-primary-cytoreduction-an-nrg-oncology-gynecologic-oncology-group-182-study
#11
Neil S Horowitz, G Larry Maxwell, Austin Miller, Chad A Hamilton, Bunja Rungruang, Noah Rodriguez, Scott D Richard, Thomas C Krivak, Jeffrey M Fowler, David G Mutch, Linda Van Le, Roger B Lee, Peter Argenta, David Bender, Krishnansu S Tewari, David Gershenson, James J Java, Michael A Bookman
OBJECTIVE: Microscopic residual disease following complete cytoreduction (R0) is associated with a significant survival benefit for patients with advanced epithelial ovarian cancer (EOC). Our objective was to develop a prediction model for R0 to support surgeons in their clinical care decisions. METHODS: Demographic, pathologic, surgical, and CA125 data were collected from GOG 182 records. Patients enrolled prior to September 1, 2003 were used for the training model while those enrolled after constituted the validation data set...
November 22, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29173893/a-novel-in-hospital-meal-service-improves-protein-and-energy-intake
#12
Dorian N Dijxhoorn, Manon G A van den Berg, Wietske Kievit, Julia Korzilius, Joost P H Drenth, Geert J A Wanten
BACKGROUND & AIMS: Improvement of hospital meal services is a strategy to optimize protein and energy intake and prevent or treat malnutrition during hospitalization. FoodforCare (FfC) is a new concept comprising 6-protein-rich meals per day, provided directly at the bedside following proactive advice from a nutritional assistant. Our aim is to investigate whether this new concept, FfC, improves dietary intake and patient satisfaction, compared to the traditional 3-meals a day service (TMS)...
November 9, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29157146/evaluation-of-rivaroxaban-use-in-patients-with-gynecologic-malignancies-at-an-academic-medical-center-a-pilot-study
#13
Jessie R Signorelli, Arpita S Gandhi
Background Patients with gynecologic malignancies are at an increased risk for venous thromboembolism. National guidelines recommend treatment of an acute venous thromboembolism with low molecular weight heparin for 5-10 days followed by long-term secondary prophylaxis with low molecular weight heparin for at least six months. Non-vitamin K oral anticoagulants are not currently recommended to be used in cancer patients for the management of venous thromboembolism because robust data on their efficacy and safety have yet to become available in cancer patients...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29151924/the-effect-of-ca125-nadir-level-on-survival-of-advanced-stage-epithelial-ovarian-carcinoma-after-interval-debulking-surgery
#14
Jing Zeng, Huizhen Huang, Ying Shan, Yan Li, Ying Jin, Lingya Pan
Purpose. The study aims at investigating the most reliable CA125-related factors in terms of predicting survival outcomes in advanced-stage epithelial ovarian carcinoma (EOC) patients received neoadjuvant chemotherapy (NAC). Methods. The EOC patients treated with NAC at Peking Union Medical College Hospital by a single gynecological oncology team were enrolled for the retrospective study. The CA125-related variables were categorized into four groups: normalizations, nadirs, half-life and percentage reductions...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29094100/primary-prevention-of-cervical-cancer-american-society-of-clinical-oncology-resource-stratified-guideline
#15
Silvina Arrossi, Sarah Temin, Suzanne Garland, Linda O'Neal Eckert, Neerja Bhatla, Xavier Castellsagué, Sharifa Ezat Alkaff, Tamika Felder, Doudja Hammouda, Ryo Konno, Gilberto Lopes, Emmanuel Mugisha, Rául Murillo, Isabel C Scarinci, Margaret Stanley, Vivien Tsu, Cosette M Wheeler, Isaac Folorunso Adewole, Silvia de Sanjosé
Purpose: To provide resource-stratified (four tiers), evidence-based recommendations on the primary prevention of cervical cancer globally. Methods: The American Society of Clinical Oncology convened a multidisciplinary, multinational panel of oncology, obstetrics/gynecology, public health, cancer control, epidemiology/biostatistics, health economics, behavioral/implementation science, and patient advocacy experts. The Expert Panel reviewed existing guidelines and conducted a modified ADAPTE process and a formal consensus-based process with additional experts (consensus ratings group) for one round of formal ratings...
October 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/29093344/a-retrospective-study-of-the-effects-of-oncology-pharmacist-participation-in-treatment-on-therapeutic-outcomes-and-medical-costs
#16
Makio Imamura, Daisuke Ogawa, Toshikazu Takatori, Maiko Yamaguchi, Tomoyuki Takata, Tomonori Hada, Yoshiaki Ota, Takashi Uehara
Specialist oncology pharmacists are being trained in Japan to assist cancer treatment teams. These specialized pharmacists address patients' physical and mental problems in pharmacist-managed cancer care clinics, actively participate in formulating treatment policies, and are beneficial in offering qualitative improvements to patient services and team medical care. However, the effect of outpatient treatment by oncology pharmacists on therapeutic outcomes and medical costs is still unknown. A retroactive comparative analysis of the treatment details and clinical course was conducted among three groups of patients: patients who underwent adjuvant chemotherapy managed by a gynecologic oncologist only (S arm), patients managed by a non-oncologist (general practice gynecologist) only (NS arm), and patients managed by both a non-oncologist and a specialist oncology pharmacist (NS+Ph arm)...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29083333/comparison-of-robotic-and-laparoscopic-radical-type-b-and-c-hysterectomy-for-cervical-cancer-long-term-outcomes
#17
Antonio Pellegrino, Gianluca Raffaello Damiani, Matteo Loverro, Cecilia Pirovano, Giorgio Fachechi, Silvia Corso, Giuseppe Trojano
STUDY OBJECTIVE: To compare the clinical and oncologic outcomes of Robotic radical hysterectomy (RRH) vs Laparoscopic radical hysterectomy (TLRH) in patients with cervical carcinoma. DESIGN: Long term follow-up in a prospective study between March 2010 to March 2016. SETTING: Oncological referral center, department of gynecology and obstetrics of Alessandro Manzoni Hospital, department of gynecology, University of San Gerardo Monza, Milan...
October 23, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29063589/endometrial-carcinoma-recurrence-according-to-race-and-ethnicity-an-nrg-oncology-gynecologic-oncology-group-210-study
#18
A S Felix, T M Brasky, D E Cohn, D G Mutch, W T Creasman, P H Thaker, J L Walker, R G Moore, S B Lele, S R Guntupalli, L S Downs, C I Nagel, J F Boggess, M L Pearl, O B Ioffe, W Deng, D S Miller, L A Brinton
Non-Hispanic black (NHB) women are more likely to experience an endometrial carcinoma (EC) recurrence compared with Non-Hispanic white (NHW) women. The extent to which tumor characteristics, socioeconomic status (SES), and treatment contribute to this observation is not well defined. In the NRG Oncology/Gynecology Oncology Group (GOG) 210 Study we evaluated associations between race and ethnicity with EC recurrence according to tumor characteristics with adjustment for potential confounders. Our analysis included 3,199 non-Hispanic white, 532 non-Hispanic black and 232 Hispanic women with EC...
October 24, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29059426/tumor-microvessel-density-as-a-potential-predictive-marker-for-bevacizumab-benefit-gog-0218-biomarker-analyses
#19
RANDOMIZED CONTROLLED TRIAL
Carlos Bais, Barbara Mueller, Mark F Brady, Robert S Mannel, Robert A Burger, Wei Wei, Koen M Marien, Mark M Kockx, Amreen Husain, Michael J Birrer
Background: Combining bevacizumab with frontline chemotherapy statistically significantly improved progression-free survival (PFS) but not overall survival (OS) in the phase III GOG-0218 trial. Evaluation of candidate biomarkers was an exploratory objective. Methods: Patients with stage III (incompletely resected) or IV ovarian cancer were randomly assigned to receive six chemotherapy cycles with placebo or bevacizumab followed by single-agent placebo or bevacizumab...
November 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29037481/surgical-outcomes-among-elderly-women-with-endometrial-cancer%C3%A2-treated-by-laparoscopic-hysterectomy-a-nrg-gynecologic-oncology-group-study
#20
Erin A Bishop, James J Java, Kathleen N Moore, Nick M Spirtos, Michael L Pearl, Oliver Zivanovic, David M Kushner, Floor Backes, Chad A Hamilton, Melissa A Geller, Jean Hurteau, Cara Mathews, Robert M Wenham, Pedro T Ramirez, Susan Zweizig, Joan L Walker
OBJECTIVE: Tolerance of and complications caused by minimally invasive hysterectomy and staging in the older endometrial cancer population is largely unknown despite the fact that this is the most rapidly growing age group in the United States. The objective of this retrospective review was to compare operative morbidity by age in patients on the Gynecologic Oncology Group Laparoscopic Surgery or Standard Surgery in Treating Patients With Endometrial Cancer or Cancer of the Uterus (LAP2) trial...
October 14, 2017: American Journal of Obstetrics and Gynecology
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