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Opioid induced alterations in mu,delta,kappa receptors and immune functions

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https://www.readbyqxmd.com/read/23164507/interleukin-1-beta-induced-up-regulation-of-opioid-receptors-in-the-untreated-and-morphine-desensitized-u87-mg-human-astrocytoma-cells
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Linda Staikos Byrne, Jinsong Peng, Sraboni Sarkar, Sulie L Chang
BACKGROUND: Interleukin-1beta (IL-1β) is a pro-inflammatory cytokine that can be produced in the central nervous system during inflammatory conditions. We have previously shown that IL-1β expression is altered in the rat brain during a morphine tolerant state, indicating that this cytokine may serve as a convergent point between the immune challenge and opiate mediated biological pathways. We hypothesized that IL-1β up-regulates opioid receptors in human astrocytes in both untreated and morphine-desensitized states...
November 20, 2012: Journal of Neuroinflammation
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