keyword
https://read.qxmd.com/read/38512243/prevalence-of-myopic-maculopathy-among-the-very-old-the-ural-very-old-study
#21
JOURNAL ARTICLE
Mukharram M Bikbov, Timur R Gilmanshin, Gyulli M Kazakbaeva, Songhomitra Panda-Jonas, Jost B Jonas
PURPOSE: To assess the prevalence of myopic macular degeneration (MMD) in very old individuals. METHODS: The population-based Ural Very Old Study (UVOS) included 1526 (81.1%) of 1882 eligible inhabitants aged ≥85 years. Assessable fundus images were available for 930 (60.9%) individuals (mean age, 88.6 ± 2.7 years). MMD was defined by macular patchy atrophies (i.e., MMD stage 3 and 4 as defined by the Pathologic Myopia Study Group). RESULTS: MMD prevalence was 21 of 930 (2...
March 5, 2024: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/38507808/bionic-blink-improves-real-time-eye-closure-in-unilateral-facial-paralysis
#22
JOURNAL ARTICLE
Mar Cervera-Negueruela, Lauren Chee, Andrea Cimolato, Giacomo Valle, Markus Tschopp, Marcel Menke, Anthia Papazoglou, Stanisa Raspopovic
Facial paralysis is the inability to move facial muscles thereby impairing the ability to blink and make facial expressions. Depending on the localization of the nerve malfunction it is subcategorised into central or peripheral and is usually unilateral. This leads to health deficits stemming from corneal dryness and social ostracization. Electrical stimulation shows promise as a method through which to restore the blink function and as a result improve eye health. However, it is unknown whether a real-time, closed-loop, neurostimulating device can be used as assistance to this pathological condition...
March 20, 2024: Journal of Neural Engineering
https://read.qxmd.com/read/38504518/socs3-regulates-pathological-retinal-angiogenesis-through-modulating-spp1-expression-in-microglia-and-macrophages
#23
JOURNAL ARTICLE
Tianxi Wang, Satoshi Kaneko, Emil Kriukov, David Alvarez, Enton Lam, Yidi Wang, Sara La Manna, Daniela Marasco, Angeles Fernandez-Gonzalez, S Alex Mitsialis, Stella Kourembanas, Andreas Stahl, Mei Chen, Heping Xu, Petr Baranov, Guoshuai Cai, Ulrich H von Andrian, Ye Sun
Pathological ocular angiogenesis has long been associated with myeloid cell activation. However, the precise cellular and molecular mechanisms governing the intricate crosstalk between the immune system and vascular changes during ocular neovascularization formation remain elusive. In this study, we demonstrated that the absence of the suppressor of cytokine signaling 3 (SOCS3) in myeloid cells led to a substantial accumulation of microglia and macrophage subsets during the neovascularization process. Our single-cell RNA sequencing data analysis revealed a remarkable increase in the expression of the secreted phosphoprotein 1 (Spp1) gene within these microglia and macrophages, identifying subsets of Spp1-expressing microglia and macrophages during neovascularization formation in angiogenesis mouse models...
March 18, 2024: Molecular Therapy
https://read.qxmd.com/read/38504301/human-adipose-tissue-derived-stem-cell-extracellular-vesicles-attenuate-ocular-hypertension-induced-retinal-ganglion-cell-damage-by-inhibiting-microglia-tlr4-mapk-nf-%C3%AE%C2%BAb-proinflammatory-cascade-signaling
#24
JOURNAL ARTICLE
Shangli Ji, Yanfang Peng, Jian Liu, Pang Xu, Shibo Tang
Microglia-mediated neuroinflammatory responses are recognized as a predominant factor during high intraocular pressure (IOP)-induced retinal and optic nerve injury along with potential therapeutic targets for the disease. Our previous research indicated that mesenchymal stem cell (MSC) treatment could reduce high IOP-induced neuroinflammatory responses through the TLR4 pathway in a rat model without apparent cell replacement and differentiation, suggesting that the anti-neuroinflammatory properties of MSCs are potentially mediated by paracrine signaling...
March 19, 2024: Acta Neuropathologica Communications
https://read.qxmd.com/read/38499288/cellular-senescence-promotes-meibomian-gland-dysfunction-in-a-chronic-graft-versus-host-disease-mouse-model
#25
JOURNAL ARTICLE
Shinri Sato, Yoko Ogawa, Eisuke Shimizu, Kazuki Asai, Takahiro Okazaki, Robert Rusch, Masatoshi Hirayama, Shigeto Shimmura, Kazuno Negishi, Kazuo Tsubota
PURPOSE: Aging is a well-established risk factor for meibomian gland dysfunction (MGD). We previously reported an accelerated cellular senescence phenomenon in the lacrimal glands of a murine model of chronic graft-versus-host disease (cGVHD). Herein, we aimed to elucidate the relationship between cellular senescence and MGD in cGVHD mice, utilizing the senolytic agent ABT-263. METHODS: A cGVHD mouse model was established through allogeneic bone marrow transplantation (BMT) from B10...
March 16, 2024: Ocular Surface
https://read.qxmd.com/read/38497871/dry-eye-disease-pathogenesis-and-clinical-signs-searching-for-correspondence-in-the-clinical-practice
#26
JOURNAL ARTICLE
S Barabino, J M Benítez-Del-Castillo
BACKGROUND: Ocular surface alterations causing dry eye disease (DED) can be described as a vicious circle consisting of different consecutive stages. Among the factors involved, the ocular surface immune-inflammatory response has been established as a key player in the pathogenesis of the vicious circle of DED. Thus, the prompt recognition of the disruption of the immunoregulatory mechanisms is crucial for properly managing the ocular surface alterations. To increase awareness and knowledge of the identification and clinical interpretation of immunological mechanisms of dry eye in clinical practice, we present two clinical cases related to DED patients to provide a practical example of clinical examination application and interpretation of diagnostic parameters in daily practice...
March 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38497384/differential-diagnosis-of-thyroid-orbitopathy-diseases-mimicking-the-presentation-or-activity-of-thyroid-orbitopathy
#27
JOURNAL ARTICLE
Mariusz Nowak, Wojciech Nowak, Bogdan Marek, Beata Kos-Kudła, Lucyna Siemińska, Magdalena Londzin-Olesik, Dariusz Kajdaniuk
Thyroid orbitopathy (TO) is the most common cause of orbital tissue inflammation, accounting for about 60% of all orbital inflammations. The inflammatory activity and severity of TO should be diagnosed based on personal experience and according to standard diagnostic criteria. Magnetic resonance imaging (MRI) of the orbit is used not only to identify swelling and to differentiate inflammatory active from non-active TO, but also to exclude other pathologies, such as orbital tumours or vascular lesions. However, a group of diseases can mimic the clinical manifestations of TO, leading to serious diagnostic difficulties, especially when the patient has previously been diagnosed with a thyroid disorder...
2024: Endokrynologia Polska
https://read.qxmd.com/read/38489843/smart-nanocarriers-for-the-treatment-of-retinal-diseases
#28
REVIEW
Shuya Liu, Zhike Yan, Zixiang Huang, Huanghao Yang, Jingying Li
Retinal diseases, such as age-related macular degeneration, diabetic retinopathy, and retinoblastoma, stand as the leading causes of irreversible vision impairment and blindness worldwide. Effectively administering drugs for retinal diseases poses a formidable challenge due to the presence of complex ocular barriers and elimination mechanisms. Over time, various approaches have been developed to fabricate drug delivery systems for improving retinal therapy including virus vectors, lipid nanoparticles, and polymers...
March 15, 2024: ACS Applied Bio Materials
https://read.qxmd.com/read/38483836/usefulness-of-schirmer-s-tear-strips-and-borosilicate-glass-tubes-in-chemical-analysis-of-human-tear-fluid-a-practical-check-in-vegf-detection
#29
JOURNAL ARTICLE
Janusz Pieczyński, Jolanta Kiewisz
INTRODUCTION: Human tears contain a number of agents which may play an important role in diagnosing local eye disorders as well as systemic diseases. The small amount of fluid obtained during the collection and the consequent difficulty in analysing it are the main problems encountered in the diagnostic process. AIM: We decided to investigate the practical usefulness of two simple methods of collecting tear fluid for chemical analysis, i.e., glass tubes and Schirmer's strips...
March 14, 2024: European Journal of Ophthalmology
https://read.qxmd.com/read/38478431/literature-commentary
#30
JOURNAL ARTICLE
(no author information available yet)
In this issue of JNO Drs. Mark L. Moster, Marc Dinkin, and Deborah I. Friedman discuss the following six articles.Zhang L, Ouyang S, Chen L, Huang H, Ou Y, Tang X. Evaluation of subjective visual vertical and horizontal in patients with acoustic neuroma based on virtual reality. Front Neurosci. 2023;17:1264585.Westgate CSJ, Kamp-Jensen C, Israelsen IME, et al. Acetazolamide and topiramate lower intracranial pressure through differential mechanisms: The effect of acute and chronic administration. Br J Pharmacol...
March 13, 2024: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://read.qxmd.com/read/38475818/transient-but-not-chronic-hyperglycemia-accelerates-ocular-glymphatic-transport
#31
JOURNAL ARTICLE
Christine Delle, Xiaowei Wang, Michael Giannetto, Evan Newbold, Weiguo Peng, Ryszard Stefan Gomolka, Antonio Ladrón-de-Guevara, Neža Cankar, Elise Schiøler Nielsen, Celia Kjaerby, Pia Weikop, Yuki Mori, Maiken Nedergaard
Glymphatic transport is vital for the physiological homeostasis of the retina and optic nerve. Pathological alterations of ocular glymphatic fluid transport and enlarged perivascular spaces have been described in glaucomatous mice. It remains to be established how diabetic retinopathy, which impairs vision in about 50% of diabetes patients, impacts ocular glymphatic fluid transport. Here, we examined ocular glymphatic transport in chronic hyperglycemic diabetic mice as well as in healthy mice experiencing a daily transient increase in blood glucose...
March 12, 2024: Fluids and Barriers of the CNS
https://read.qxmd.com/read/38472987/cardiac-surgery-patients-have-reduced-vascularity-and-structural-defects-of-the-retina-similar-to-persons-with-open-angle-glaucoma
#32
JOURNAL ARTICLE
Gabija Vičaitė, Liveta Barišauskaitė, Viktorija Bakstytė, Brent Siesky, Alice Verticchio Vercellin, Ingrida Janulevičienė
(1) Background: Growing evidence suggests impairment of ocular blood flow in open-angle glaucoma (OAG) pathology, but little is known about the effect of an impaired cardiovascular supply on the structural and vascular parameters of the retina. This study aims to investigate the variations of these parameters in OAG patients compared to patients undergoing cardiac surgery (CS) with cardiopulmonary bypass. (2) Methods: Prospective observational study with 82 subjects (30 controls, 33 OAG patients, and 19 CS patients) who underwent ophthalmological assessment by swept-source OCT and CDI in one randomly selected eye...
February 29, 2024: Diagnostics
https://read.qxmd.com/read/38465143/referral-of-a-patient-with-ocular-symptoms-to-the-stroke-clinic-not-always-the-usual-suspect
#33
Kayteck Ling, Saugata Das, Sanjay Vydianath
A 77-year-old male attended the stroke clinic as a delayed presentation of a stroke and was initially managed as an occipital stroke. He presented with a gradual decline in visual acuity with an initial suspicion of field deficit over a period of three to four months. He underwent extensive tests including imaging for a confirmatory diagnosis. He had a rapid deterioration of his vision, function, and cognition over a few weeks resulting eventually in death. The case highlights a rare variant of sporadic Creutzfeld-Jakob disease (sCJD), the Heidenhain Variant (HV-CJD)...
February 2024: Curēus
https://read.qxmd.com/read/38461261/familial-primary-calcific-band-shaped-keratopathy-with-late-onset-systemic-disease-a-case-series-and-review-of-the-literature
#34
REVIEW
Parisa Abdi, Hassan Asadigandomani, Arman Amirkhani, Sara Taghizadeh, Zohreh Nozarian
BACKGROUND: Familial calcific band-shaped keratopathy (BSK) is a very rare disease, with no underlying cause. There is no underlying disease in this form of the disease. This article introduces a family with seven children, three of whom were diagnosed with familial primary calcific BSK. One of them developed a systemic disease 38 years after ocular manifestation. CASE PRESENTATION: In this case report, three Iranian siblings from a family with familial calcific band-shaped keratopathy (BSK) are introduced...
March 10, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38460758/how-gut-microbiota-may-impact-ocular-surface-homeostasis-and-related-disorders
#35
REVIEW
Marc Labetoulle, Christophe Baudouin, Jose M Benitez Del Castillo, Maurizio Rolando, Maria Rescigno, Elisabeth M Messmer, Pasquale Aragona
Changes in the bacterial flora in the gut, also described as gut microbiota, are readily acknowledged to be associated with several systemic diseases, especially those with an inflammatory, neuronal, psychological or hormonal factor involved in the pathogenesis and/or the perception of the disease. Maintaining ocular surface homeostasis is also based on all these four factors, and there is accumulating evidence in the literature on the relationship between gut microbiota and ocular surface diseases. The mechanisms involved are mostly interconnected due to the interaction of central and peripheral neuronal networks, inflammatory effectors and the hormonal system...
March 7, 2024: Progress in Retinal and Eye Research
https://read.qxmd.com/read/38457929/trpv4-antagonist-suppresses-retinal-ganglion-cell-apoptosis-by-regulating-the-activation-of-camkii-and-tnf-%C3%AE-expression-in-a-chronic-ocular-hypertension-rat-model
#36
JOURNAL ARTICLE
Wenhui Liu, Wenzhe Zhang, Chen Wang, Jiarun Song, Kaiyue Li, Xia Zhang, Xinyi Wu, Hui Guo
Glaucoma is characterized by a progressive loss of retinal ganglion cells (RGCs), leading to irreversible visual function impairment. Sustained increase in intraocular pressure represents a major risk factor for glaucoma, yet the underlying mechanisms of RGC apoptosis induced by intraocular pressure remains unclear. This study aims to investigate the role of TRPV4 in RGC apoptosis in a rat model of chronic ocular hypertension (COH) and the underlying molecular mechanism. In the COH rat models, we evaluated the visual function, retinal pathological changes and RGC apoptosis...
March 7, 2024: International Immunopharmacology
https://read.qxmd.com/read/38457332/ocular-surface-information-seen-from-the-somatosensory-thalamus-and-cortex
#37
JOURNAL ARTICLE
Enrique Velasco, Marta Zaforas, M Carmen Acosta, Juana Gallar, Juan Aguilar
Ocular Surface (OS) somatosensory innervation detects external stimuli producing perceptions, such as pain or dryness, the most relevant symptoms in many OS pathologies. Nevertheless, little is known about the central nervous system circuits involved in these perceptions, and how they integrate multimodal inputs in general. Here, we aim to describe the thalamic and cortical activity in response to OS stimulation of different modalities. Electrophysiological extracellular recordings in anaesthetized rats were used to record neural activity, while saline drops at different temperatures were applied to stimulate the OS...
March 8, 2024: Journal of Physiology
https://read.qxmd.com/read/38455056/a-case-of-igg4-related-ophthalmic-disease-after-sars-cov-2-vaccination-case-report-and-literature-review
#38
REVIEW
Peixuan Zhang, Qian Wu, Xiao Xu, Minliang Chen
Coronavirus disease 19 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is affecting the world with a surge in cases. A variety of autoimmune diseases occur after SARS-CoV-2 infection or vaccination, of which IgG4-related disease (IgG4-RD) is an important type. IgG4-RD can involve multiple organs of the body. The ocular manifestation of IgG4-RD is called IgG4-related ophthalmic disease (IgG4-ROD). We herein report a patient diagnosed with IgG4-ROD. The patient developed ptosis and vision loss after SARS-CoV-2 vaccination, and the symptoms worsened after SARS-CoV-2 infection...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38454499/relationship-between-automated-choroidal-thickness-measurements-and-retinal-sensitivity-using-microperimetry-in-patients-with-myopia-and-different-stages-of-myopic-maculopathy
#39
JOURNAL ARTICLE
Fillipe de Biaggi Borges da Silva, Luis Claudio Pimentel Silva, Leonardo Provetti Cunha, Leandro Cabral Zacharias, Eduardo V Navajas, Mario L R Monteiro, Rony C Preti
PURPOSE: To assess the relationship between macular choroidal thickness (CT) measurements and retinal sensitivity (RS) in eyes with myopia and different stages of myopic maculopathy. METHODS: A masked, cross-sectional, and consecutive study involving patients with emmetropia/myopia (control group) and high myopia (HM) eyes. Automated choroidal thickness (CT) and manual outer retinal layer (ORL) thickness were acquired using swept-source optical coherence tomography, while retinal sensitivity (RS) assessed by microperimetry (MP3) in all regions of the macular Early Treatment Diabetic Retinopathy Study (ETDRS) grid...
March 8, 2024: International Journal of Retina and Vitreous
https://read.qxmd.com/read/38453262/astigmatism-and-maternal-myopia-as-important-factors-affecting-success-rate-of-dims-lens-treatment
#40
JOURNAL ARTICLE
Patricia Domsa, Éva M Bankó, Judit Körtvélyes, Christof Meigen, Rita Széchey, Krisztina Lantos, Zoltán Zsolt Nagy, Adrienne Csutak
OBJECTIVE: To assess the efficacy of myopia control spectacle lenses (defocus incorporated multiple segments/DIMS) in slowing myopia progression among a diverse Central European paediatric population and investigate the contribution of baseline parameters on treatment outcomes. METHODS AND ANALYSIS: This retrospective observational study included 62 individuals aged 4-17 years (mean±SD: 10.21±2.70) with progressing myopia but without ocular pathology with a range of -0...
March 7, 2024: BMJ Open Ophthalmology
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