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https://www.readbyqxmd.com/read/28440253/evaluation-of-meibomian-gland-and-tear-film-changes-in-patients-with-pterygium
#1
Fen Ye, Fen Zhou, Yuan Xia, Xiaomin Zhu, Yan Wu, Zhenping Huang
BACKGROUND: Recent studies have demonstrated that pterygium has a close relationship with dry eye disease. This study is to determine abnormalities in meibomian gland and tear function in patients with pterygium and to assess the relationship between the variables. MATERIALS AND METHODS: Forty eyes from forty patients with primary nasal pterygium and forty eyes from forty volunteers without ocular pathologies were enrolled in this study. Ocular surface disease index scores, meibomian gland expression scores, lid margin abnormality scores, meiboscore, tear film breakup time (BUT), Schirmer test (SIT) value, and the lower tear meniscus height (TMH), tear meniscus depth (TMD), and tear meniscus area (TMA) using Fourier domain optical coherence were performed...
March 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28436752/quantitative-mr-imaging-of-intra-orbital-structures-tissue-specific-measurements-and-age-dependency-compared-to-extra-orbital-structures-using-multispectral-quantitative-mr-imaging
#2
Memi Watanabe, Karen Buch, Akifumi Fujita, Hernán Jara, Muhammad Mustafa Qureshi, Osamu Sakai
The orbit can be affected by unique pathologic conditions and often requires MRI evaluation. The purpose of this study was to investigate the age-related changes in multiple intra-orbital structures using quantitative MRI (qMRI). Thirty-eight subjects (20 males, 18 females; ages 0.5-87 years) underwent MRI with a mixed turbo spin echo sequence. T1 and T2 measurements were obtained within ROI in 6 intra-orbital structures (medial and lateral rectus muscles, medial and lateral retrobulbar fat, lacrimal gland, and optic nerve), and compared with those of corresponding extra-orbital structures (masseter muscle, subcutaneous cheek fat, buccal fat, parotid gland, and frontal white matter)...
April 24, 2017: Orbit
https://www.readbyqxmd.com/read/28427063/optical-coherence-tomography-angiography-in-diabetic-maculopathy
#3
Gabriel Coscas, Marco Lupidi, Florence Coscas
Fluorescein angiography (FA) and indocyanine green angiography have provided information about the normal retinal and choroidal anatomy, nearly comparable to histological findings. These tests have been fundamental in the evaluation of all retinal and choroidal vascular diseases and have allowed clinicians to define and diagnose several pathological conditions. FA became the "gold standard" in retinal imaging due to the capacity to visualize the retinal capillary bed and its changes, both in the macular area and in the periphery...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28420956/retinal-gene-therapy-surgical-vector-delivery-in-the-translation-to-clinical-trials
#4
REVIEW
G Alex Ochakovski, K Ulrich Bartz-Schmidt, M Dominik Fischer
An exceptionally high number of monogenic disorders lead to incurable blindness, making them targets for the development of gene-therapy. In order to successfully apply therapeutic vector systems in vivo, the heterogeneity of the disease phenotype needs to be considered. This necessitates tailored approaches such as subretinal or intravitreal injections with the aim to maximize transduction of target cell populations, while minimizing off-target effects and surgical complications. Strategic decisions on parameters of the application are crucial to obtain the best treatment outcomes and patient safety...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28420327/clinical-predictors-for-the-prognosis-of-myasthenia-gravis
#5
Lili Wang, Yun Zhang, Maolin He
BACKGROUND: Clinical predictors for myasthenia gravis relapse and ocular myasthenia gravis secondary generalization during the first two years after disease onset remain incompletely identified. This study attempts to investigate the clinical predictors for the prognosis of Myasthenia Gravis. METHODS: Eighty three patients with myasthenia gravis were concluded in this study. Baseline characteristics were analyzed as predictors. RESULTS: Relapse of myasthenia gravis developed in 26 patients (34%)...
April 19, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28418947/sleep-induced-apraxia-of-eyelid-opening
#6
Sara N Reggie, John J Chen, Michael S Lee, Sophia M Chung
BACKGROUND: Apraxia of eyelid opening (AEO) primarily has been described as bilateral loss of volitional ability to open the eyes at certain times and often associated with neurodegenerative disease. Rarely, it can occur in isolation and as an idiopathic phenomenon. There are a few reports of unilateral AEO only on awakening from sleep. We report an additional 11 patients with this unusual variation of AEO. METHODS: Retrospective, observational case series of patients collected from 3 separate neuro-ophthalmology practices...
April 14, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/28416927/cataract-surgery-and-possible-complications-in-patients-with-pseudoexfoliation-syndrome
#7
Gulsum Egemen Erkayhan, Semih Dogan
OBJECTIVE: The aim of this study was to evaluate the demographic characteristics and intraoperative complications of cataract surgery in patients with pseudoexfoliation syndrome (PEX). MATERIALS AND METHODS: Cases of 225 eyes (80 eyes with pseudoexfoliation and 145 eyes without pseudoexfoliation as the control group) that underwent phacoemulsification cataract surgery and IOL implantation at the Silifke State Hospital Ophthalmology Clinic between April 2011 and April 2013 were analysed retrospectively...
February 2017: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/28416107/characteristics-of-the-peritumoral-pseudocapsule-vary-predictably-with-histologic-subtype-of-t1-renal-neoplasms-jacob-jm-williamson-sr-gondim-dd-leese-ja-terry-c-grignon-dj-boris-rs-urology-november-2015-86-5-956-961
#8
Oleksandr N Kryvenko
OBJECTIVE: To determine characteristics of the peritumoral pseudocapsule (PC) between renal tumor subtypes. METHODS: The peritumoral PCs of 160 pT1 renal tumors were examined, including 60 clear cell renal cell carcinomas (RCCs), 50 papillary RCCs, 25 chromophobe RCCs, and 25 oncocytoma. Pathologic features (presence or absence of PC, mean thickness, continuity, and invasion by tumor) were analyzed. PC thickness was measured using an ocular micrometer to the nearest 1/10mm...
April 13, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28414592/understanding-the-presence-and-roles-of-ap4a-diadenosine-tetraphosphate-in-the-eye
#9
Almudena Crooke, Ana Guzman-Aranguez, Gonzalo Carracedo, Maria J Perez de Lara, Jesus Pintor
Diadenosine tetraphosphate abbreviated Ap4A is a naturally occurring dinucleotide, which is present in most of the ocular fluids. Due to its intrinsic resistance to enzyme degradation compared to mononucleotides, this molecule can exhibit profound actions on ocular tissues, including the ocular surface, ciliary body, trabecular meshwork, and probably the retina. The actions of Ap4A are mostly carried out by P2Y2 receptors, but the participation of P2X2 and P2Y6 in processes such as the regulation of intraocular pressure (IOP), together with the P2Y2, is pivotal...
April 17, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28413548/an-interesting-case-of-wrongly-diagnosed-optic-neuritis
#10
Vivek Tandon, Kanwaljeet Garg, Ashok K Mahapatra
Optic neuritis (ON) may rarely mimic optic nerve tumor, index of suspicion should be kept high. A 34-year-old woman presented to a major academic institute with a history of right-sided ocular pain and progressive visual loss in the same eye. Her magnetic resonance imaging showed markedly thickened optic nerve; her workup for inflammatory pathology was negative; she was diagnosed as a case of optic nerve tumor and was planned for surgery. Patient for second opinion came to a tertiary care institute where on proper history taking and evaluation she was diagnosed and treated on the lines of ON and she improved...
January 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28405486/rare-clinical-sign-of-hodgkin-s-lymphoma-ocular-involvement
#11
Ziya Ayhan, Revan Yıldırım Karabağ, İnci Alacacıoğlu, Süleyman Kaynak, Nilüfer Koçak
Bilateral non-granulomatous anterior uveitis with left vitritis and macular edema were detected in a 19-year-old woman presenting with blurred vision in her left eye. Light microscopic study of the pathologic mediastinal lymph node that was detected via contrast computed tomography imaging during etiologic study revealed nodular sclerosing and mixed cellularity Hodgkin's lymphoma (HL). Ocular findings completely resolved with adriablastin, bleomycin, vinblastine, dacarbazine chemotherapy treatment. Herein, it is emphasized that HL should be remembered as one of the differential diagnoses in patients with ocular inflammatory pathologies such as uveitis and vasculitis...
April 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28400276/optic-disc-hemorrhage-in-health-and-disease
#12
REVIEW
M Reza Razeghinejad, M Hossein Nowroozzadeh
Optic disc hemorrhage occurs in all age groups from neonates to the elderly . Optic disc hemorrhage is best known for its association with visual field loss and progression in patients with glaucoma; however, it may occur in conjunction with other ocular or systemic conditions as well as in otherwise healthy individuals. It may also be the first sign of a sight-threatening condition. Variations in the shape, location, and size of the optic disc hemorrhage, as well as associated ocular and systemic signs or symptoms, may help determine the underlying pathology...
April 8, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28389675/deformation-of-the-lamina-cribrosa-and-optic-nerve-due-to-changes-in-cerebrospinal-fluid-pressure
#13
Andrew J Feola, Baptiste Coudrillier, John Mulvihill, Diogo M Geraldes, Nghia T Vo, Julie Albon, Richard L Abel, Brian C Samuels, C Ross Ethier
Purpose: Cerebrospinal fluid pressure (CSFp) changes are involved or implicated in various ocular conditions including glaucoma, idiopathic intracranial hypertension, and visual impairment and intracranial pressure syndrome. However, little is known about the effects of CSFp on lamina cribrosa and retrolaminar neural tissue (RLNT) biomechanics, potentially important in these conditions. Our goal was to use an experimental approach to visualize and quantify the deformation of these tissues as CSFp increased...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28385277/ocular-pathology-in-the-nobleman-with-his-hand-on-his-chest-dom%C3%A3-nikos-theotok%C3%A3-poulos-el-greco
#14
E Santos-Bueso, A Arteaga-Sánchez, J Porta-Etessam, J M Vinuesa-Silva, J García-Sánchez
No abstract text is available yet for this article.
April 3, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28380076/strength-of-baseline-inter-trial-correlations-forecasts-adaptive-capacity-in-the-vestibulo-ocular-reflex
#15
Kara H Beaton, Aaron L Wong, Steven B Lowen, Mark Shelhamer
Individual differences in sensorimotor adaptability may permit customized training protocols for optimum learning. Here, we sought to forecast individual adaptive capabilities in the vestibulo-ocular reflex (VOR). Subjects performed 400 head-rotation steps (400 trials) during a baseline test, followed by 20 min of VOR gain adaptation. All subjects exhibited mean baseline VOR gain of approximately 1.0, variable from trial to trial, and showed desired reductions in gain following adaptation with variation in extent across individuals...
2017: PloS One
https://www.readbyqxmd.com/read/28378910/innovative-methods-and-applications-in-mucoadhesion-research
#16
REVIEW
Alan R Mackie, Francisco M Goycoolea, Bianca Menchicchi, Carla Marcella Caramella, Francesca Saporito, Seunghwan Lee, Karen Stephansen, Ioannis S Chronakis, Marianne Hiorth, Malgorzata Adamczak, Max Waldner, Hanne Mørck Nielsen, Luciano Marcelloni
The present review is aimed at elucidating relatively new aspects of mucoadhesion/mucus interaction and related phenomena that emerged from a Mucoadhesion workshop held in Munster on 2-3 September 2015 as a satellite event of the ICCC 13th-EUCHIS 12th. After a brief outline of the new issues, the focus is on mucus description, purification, and mucus/mucin characterization, all steps that are pivotal to the understanding of mucus related phenomena and the choice of the correct mucosal model for in vitro and ex vivo experiments, alternative bio/mucomimetic materials are also presented...
April 5, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28374616/treatment-of-barrow-type-b-carotid-cavernous-fistulas-with-flow-diverter-stent-pipeline
#17
Carlos Castaño, Sebastián Remollo, Rosa García-Sort, Carlos Domínguez, Mikel Terceño
Background Carotid cavernous fistulas (CCFs) Barrow type 'B' are dural shunts between the meningeal branches of the internal carotid artery and the cavernous sinus. The symptoms include vision deterioration, ophthalmoplegia with diplopia, exophthalmos, conjunctival injection, chemosis, ocular bruit, seizures, or neurological deficit. Endovascular treatment remains the gold standard for treatment through the transvenous or transarterial routes. The transvenous approaches have been proved to be the first option...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28371493/efficacy-of-nutritional-supplementation-with-omega-3-and-omega-6-fatty-acids-in-dry-eye-syndrome-a-systematic-review-of-randomized-clinical-trials
#18
Ignacio Molina-Leyva, Alejandro Molina-Leyva, Aurora Bueno-Cavanillas
PURPOSE: To critically appraise scientific evidence regarding the efficacy of nutritional supplementation with omega-3 and omega-6 fatty acids for the treatment of dry eye syndrome (DES). METHODS: A systematic review of randomized clinical trials was performed. Two independent reviewers selected and analysed the scientific papers that met inclusion and exclusion criteria. Objective and subjective efficacy outcomes were assessed. RESULTS: The trials involved a total of 2591 patients in fifteen independent studies...
March 30, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28368307/trpv4-stimulation-induced-melatonin-secretion-by-increasing-arylalkymine-n-acetyltransferase-aanat-protein-level
#19
Hanan Awad Alkozi, Maria J Perez de Lara, Juan Sánchez-Naves, Jesús Pintor
Melatonin is a molecule which has gained a great deal of interest in many areas of science; its synthesis was classically known to be in the pineal gland. However, many organs synthesize melatonin, such as several ocular structures. Melatonin is known to participate in many functions apart from its main action regulating the circadian rhythm. It is synthesized from serotonin in two steps, with a rate-limiting step carried out by arylalkymine N-acetyltransferase (AANAT). In this report, the role of TRPV4 channel present in human ciliary body epithelial cells in AANAT production was studied...
April 1, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28366874/impaired-vitreous-composition-and-retinal-pigment-epithelium-function-in-the-foxg1-lrp2-myopic-mice
#20
Olivier Cases, Antoine Obry, Sirine Ben-Yacoub, Sébastien Augustin, Antoine Joseph, Géraldine Toutirais, Manuel Simonutti, Annabel Christ, Pascal Cosette, Renata Kozyraki
High myopia (HM) is one of the main causes of visual impairment and blindness all over the world and an unsolved medical problem. Persons with HM are predisposed to other eye pathologies such as retinal detachment, myopic retinopathy or glaucomatous optic neuropathy, complications that may at least partly result from the extensive liquefaction of the myopic vitreous gel. To identify the involvement of the liquid vitreous in the pathogenesis of HM we here analyzed the vitreous of the recently described highly myopic low density lipoprotein receptor-related protein 2 (Lrp2)-deficient eyes...
March 30, 2017: Biochimica et Biophysica Acta
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