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Ocular pathology

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https://www.readbyqxmd.com/read/28323487/pathological-eye-movements-influence-on-the-recordings-of-ocular-vestibular-evoked-myogenic-potential
#1
Ting-Hua Yang, Hsin-Lin Chen, Yi-Ho Young
OBJECTIVE: This study investigated the influence of pathological eye movements on the recordings of ocular vestibulo-evoked myogenic potential (oVEMP). METHODS: Ten patients with pathological eye movements of non-vestibular origin (nine congenital nystagmus and one opsoclonus) who had negative MRI result were assigned to Group A. Another 20 vestibular neuritis (VN) patients with spontaneous nystagmus were assigned to Group B. Both groups underwent audiometry, and caloric, oVEMP and cervical VEMP (cVEMP) tests...
March 21, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28318718/-treatment-of-macular-edema-comparison-of-efficacy-and-tolerability-of-subconjunctival-triamcinolone-injections-sub-tenon-s-triamcinolone-injections-and-intravitreal-dexamethasone-implant
#2
C Carbonnière, C Couret, A Blériot, O Lebreton, H Massé, G Le Meur, P Lebranchu, M Weber
The area of uveitis is related to numerous pathological entities. One of the main causes of decreased visual acuity in these patients is macular edema. One aspect of the treatment includes cortosteroids used peri- and intra-ocularly. MATERIALS AND METHODS: The goal of our work was to estimate the criteria of efficacy (on improvement in visual acuity and macular edema, as well as time to recurrence) and safety (on intraocular pressure and cataract) of these various routes of administration of corticosteroid after a single injection...
March 16, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28316191/-in-vivo-confocal-microscopic-observation-of-corneal-changes-in-patients-with-chronic-stevens-johnson-syndrome-or-toxic-epidermal-necrolysis
#3
T T Gao, Y Li, J Liu, Q Long
Objective: To describe corneal alterations visible on in vivo confocal microscopy in patients with debilitating ocular sequelae caused by Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN). Methods: Twenty-two eyes of 11 consecutive patients suffering from chronic SJS or TEN were studied using slit lamp and in vivo confocal microscopy in the Ophthalmology Outpatient Department of Peking Union Medical College Hospital from March 2014 to April 2015. Results: Dry eye with meibomian gland dysfunction (19 eyes of 10 patients, 86...
March 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28302681/ultrasound-biomicroscopic-imaging-in-paediatric-ocular-toxocariasis
#4
Jinghua Liu, Songfeng Li, Guangda Deng, Wenli Yang, Wei Chen, Hai Lu
PURPOSE: To determine the potential and usefulness of ultrasound biomicroscopy (UBM) as a diagnostic procedure on a larger cohort of paediatric patients with ocular toxocariasis. METHODS: UBM was performed on 41 eyes of 41 patients with ocular toxocariasis in order to determine configuration of peripheral retina, pars plana and vitreous. Location and range of peripheral pathology using ophthalmoscopy with scleral indentation, UBM and intraoperative confirmation were recorded and compared...
March 16, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28298856/applications-of-polymers-in-intraocular-drug-delivery-systems
#5
REVIEW
Ali Mohammed Alhalafi
We are entering a new era of ophthalmic pharmacology where new drugs are rapidly being developed for the treatment of anterior and posterior segment of the eye disease. The pharmacokinetics of drug delivery to the eye remains a very active area of ophthalmic research. Intraocular drug delivery systems allow the release of the drug, bypassing the blood-ocular barrier. The main advantage of these preparations is that they can release the drug over a long time with one single administration. These pharmaceutical systems are of great important in the treatment of the posterior segment diseases, and they can be prepared from biodegradable or nonbiodegradable polymers...
January 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/28291193/-surgical-rehabilitation-of-patients-with-thyroid-eye-disease-systematic-approach
#6
S E Avetisov, Ya O Grusha, D S Ismailova, P A Kochetkov, S S Danilov, N Yu Sviridenko
AIM: to analyze the results of surgical treatment of patients with thyroid eye disease (TED), including the type of surgery, indications, and outcomes. MATERIAL AND METHODS: Hundred thirty-nine patients with TED (112 females, 27 males) aged 45.8±13.6 years. RESULTS: Bony orbital decompression was performed in 91 patients (128 orbits). After the surgery, visual acuity increased from 0.84±0.47 up to 0.94±0.32 (р<0.05), exophthalmos got reduced by the average of 3...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28284957/proteolytic-activity-in-the-meibomian-gland-implications-to-health-and-disease
#7
REVIEW
Pablo Argüeso
The function of the meibomian gland in the upper and lower eyelids is critical to maintaining homeostasis at the ocular surface. Highly specialized meibocytes within the gland must differentiate and accumulate intracellular lipid droplets that are released into the tear film following rupture of the cell membrane. Proteases and their inhibitors have been recognized as key players in remodeling extracellular matrices and promoting the normal integrity of glandular tissue. They modulate a wide range of biological processes, such as cell proliferation and differentiation, and can contribute to disease when aberrantly expressed...
March 8, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28276715/inflammation-in-sj%C3%A3-gren-s-syndrome-cause-or-consequence
#8
Ana Raquel Rodrigues, Raquel Soares
Sjögren's syndrome (SS) is an autoimmune disease most commonly characterized by ocular and oral dryness. Despite the high prevalence of SS, generation and perpetuation of this disease is still unclear in many aspects. Inflammation, nonetheless, seems to play a central role in this pathology especially in the form of Th-1, Th-2 and Th-17 cytokines release within different aspects, concentrations and connections involved in the maintenance of the syndrome. Moreover, the chronically created pro-inflammatory environment appears to promote glandular atrophy and irreparable architectural modifications...
February 14, 2017: Autoimmunity
https://www.readbyqxmd.com/read/28275607/intracorneal-and-intraocular-invasion-of-ocular-surface-squamous-neoplasia-after-intraocular-surgery-report-of-two-cases-and-review-of-the-literature
#9
Juan C Murillo, Anat Galor, Michael C Wu, Natasha K Kye, James Wong, Ibrahim O Ahmed, Madhura Joag, Nabeel Shalabi, William Lahners, Sander Dubovy, Carol L Karp
PURPOSE: The aim of this paper was to describe 2 cases of ocular surface squamous neoplasia (OSSN) of the conjunctiva with intracorneal and intraocular extension following intraocular surgery. METHODS: We conducted a clinical pathological retrospective case series. RESULTS: Case 1 underwent cataract surgery in the setting of an unnoticed adjacent OSSN. An excisional biopsy with cryotherapy and intraoperative mitomycin C was subsequently performed, confirming OSSN...
January 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/28274286/galectins-expressed-differently-in-genetically-susceptible-c57bl-6-and-resistant-balb-c-mice-during-acute-ocular-toxoplasma-gondii-infection
#10
S-J Chen, Y-X Zhang, S-G Huang, F-L Lu
Ocular toxoplasmosis (OT) caused by Toxoplasma gondii is a major cause of infectious uveitis, however little is known about its immunopathological mechanism. Susceptible C57BL/6 (B6) and resistant BALB/c mice were intravitreally infected with 500 tachyzoites of the RH strain of T. gondii. B6 mice showed more severe ocular pathology and higher parasite loads in the eyes. The levels of galectin (Gal)-9 and its receptors (Tim-3 and CD137), interferon (IFN)-γ, IL-6 and IL-10 were significantly higher in the eyes of B6 mice than those of BALB/c mice; however, the levels of IFN-α and -β were significantly decreased in the eyes and CLNs of B6 mice but significantly increased in BALB/c mice after infection...
March 9, 2017: Parasitology
https://www.readbyqxmd.com/read/28273971/clinico-pathological-spectrum-of-ophthalmic-lesions-an-experience-in-tertiary-care-hospital-of-central-india
#11
Yashita Gupta, Renuka Gahine, Nighat Hussain, Mohd Jafar Memon
INTRODUCTION: Ophthalmic lesions show varied distribution on the basis of geographical location. Eye being a unique sensory organ needs to be studied both clinically and pathologically. AIM: This study was aimed to evaluate the histomorphological and clinico-pathlological spectrum of ophthalmic lesions at a tertiary care hospital of Central India. MATERIALS AND METHODS: We reviewed all the ophthalmic biopsies performed in the Department of Pathology of our institute between January 2008 and November 2014...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28273097/characterization-of-the-human-aqueous-humour-proteome-a-comparison-of-the-genders
#12
Natarajan Perumal, Caroline Manicam, Matthias Steinicke, Sebastian Funke, Norbert Pfeiffer, Franz H Grus
Aqueous humour (AH) is an important biologic fluid that maintains normal intraocular pressure and contains proteins that regulate the homeostasis of ocular tissues. Any alterations in the protein compositions are correlated to the pathogenesis of various ocular disorders. In recent years, gender-based medicine has emerged as an important research focus considering the prevalence of certain diseases, which are higher in a particular sex. Nevertheless, the inter-gender variations in the AH proteome are unknown...
2017: PloS One
https://www.readbyqxmd.com/read/28272212/ophthalmic-manifestations-in-igg4-related-disease-clinical-presentation-and-response-to-treatment-in-a-french-case-series
#13
Mikael Ebbo, Matthieu Patient, Aurelie Grados, Matthieu Groh, Julien Desblaches, Eric Hachulla, David Saadoun, Sylvain Audia, Aude Rigolet, Benjamin Terrier, Antoinette Perlat, Constance Guillaud, Frederic Renou, Emmanuelle Bernit, Nathalie Costedoat-Chalumeau, Jean-Robert Harlé, Nicolas Schleinitz
IgG4-related disease (IgG4-RD) is characterized by variable tissue or organ involvements sharing common pathological findings. Orbital or orbital adnexa involvement of the disease has been reported in a few case series. The aim of our study was to characterize and analyze ophthalmic manifestations from a nationwide French case-series.Patients with IgG4-RD and orbital or orbital adnexa involvement included in the French multicentric IgG4-RD case-registry were identified. Only patients fulfilling "modified" comprehensive diagnostic criteria with pathological documentation were retained for the study...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28272191/spontaneous-suprachoroidal-hemorrhage-associated-with-iatrogenic-coagulopathy
#14
Fatma Sema Akkan Aydoğmuş, Kurtulus Serdar, Defne Kalayci, Ayşenur Çelik
PURPOSE: To present a case of spontaneous suprachoroidal hemorrhage in a patient on anticoagulation. METHODS: Single case report. RESULTS: A 68-year-old woman with a history of hypertension, atherosclerosis, and heart failure presented with massive spontaneous suprachoroidal hemorrhage in the left eye. She had no known ophthalmic pathology. She was taking warfarin and she had a high international normalization ratio. Despite medical and surgical therapy, there was no improvement and vision deteriorated to no light perception...
March 7, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28270999/fully-automated-diagnosis-of-papilledema-through-robust-extraction-of-vascular-patterns-and-ocular-pathology-from-fundus-photographs
#15
Khush Naseeb Fatima, Taimur Hassan, M Usman Akram, Mahmood Akhtar, Wasi Haider Butt
Rapid development in the field of ophthalmology has increased the demand of computer aided diagnosis of various eye diseases. Papilledema is an eye disease in which the optic disc of the eye is swelled due to an increase in intracranial pressure. This increased pressure can cause severe encephalic complications like abscess, tumors, meningitis or encephalitis, which may lead to a patient's death. Although there have been several papilledema case studies reported from a medical point of view, only a few researchers have presented automated algorithms for this problem...
February 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28265260/role-of-the-patient-s-history-of-vestibular-symptoms-in-the-clinical-evaluation-of-the-bedside-head-impulse-test
#16
Christoph Helmchen, Julia Knauss, Peter Trillenberg, Anita Frendl, Andreas Sprenger
OBJECTIVE: Our aim was to identify the role of the investigators' knowledge of the patient's history of vestibular symptoms (PVH) in the clinical evaluation of the bedside head-impulse test (bHIT). We hypothesized that this knowledge will reduce uncertainty and improve bHIT accuracy when compared to quantitative analysis of the vestibulo-ocular reflex by video head-impulse test (vHIT). METHODS: We looked for changes in the clinical assessment of the bHIT in 594 consecutive patients before and after taking PVH...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28258620/changes-in-lipidomic-profile-of-aqueous-humour-in-fuchs-endothelial-dystrophy
#17
Javier Cabrerizo, Javier Aritz Urcola, Elena Vecino, Gerrit Melles
PURPOSE: To identify and determine differences in lipid profile of aqueous humour (AH) in patients with Fuchs endothelial corneal dystrophy (FECD). METHODS: Lipidomic profile of eight AH samples of FECD patients and 10 control samples was analysed. Patients with previous history of anterior segment surgery, anterior segment pathology or intraocular injections were excluded. Topical ocular medications within the last 6 months were reported. Aqueous humour (AH) was obtained during the first step of Descemet membrane endothelial keratoplasty in FECD patients and during refractive lensectomy in the control group...
March 4, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28258307/nutrition-for-diabetic-retinopathy-plummeting-the-inevitable-threat-of-diabetic-vision-loss
#18
REVIEW
Yashodhara Sharma, Sandeep Saxena, Arvind Mishra, Anita Saxena, Shankar Madhav Natu
Diabetic retinopathy (DR) is among the leading causes of preventable blindness. Hyperglycemia, hypertension, hyperlipidemia and anemia majorly predispose its pathogenesis. The current treatment modalities of DR include laser photocoagulation therapy, intravitreal corticosteroids, intravitreal anti-vascular endothelial growth factor (VEGF) agents and vitreo-retinal surgery which are costly, highly invasive, unproven for prolonged use and opted in advanced stages of DR. By then retina already encounters a vast damage...
March 3, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28255299/selenium-and-thyroid-disease-from-pathophysiology-to-treatment
#19
REVIEW
Mara Ventura, Miguel Melo, Francisco Carrilho
Introduction. Selenium is a micronutrient embedded in several proteins. In adults, the thyroid is the organ with the highest amount of selenium per gram of tissue. Selenium levels in the body depend on the characteristics of the population and its diet, geographic area, and soil composition. In the thyroid, selenium is required for the antioxidant function and for the metabolism of thyroid hormones. Methods. We performed a review of the literature on selenium's role in thyroid function using PubMed/MEDLINE...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28253913/retinal-vascular-and-structural-changes-are-associated-with-amyloid-burden-in-the-elderly-ophthalmic-biomarkers-of-preclinical-alzheimer-s-disease
#20
S Mojtaba Golzan, Kathryn Goozee, Dana Georgevsky, Alberto Avolio, Pratishtha Chatterjee, Kaikai Shen, Vivek Gupta, Roger Chung, Greg Savage, Carolyn F Orr, Ralph N Martins, Stuart L Graham
BACKGROUND: Retinal imaging may serve as an alternative approach to monitor brain pathology in Alzheimer's disease (AD). In this study, we investigated the association between retinal vascular and structural changes and cerebral amyloid-β (Aβ) plaque load in an elderly cohort. METHODS: We studied a total of 101 participants, including 73 elderly subjects (79 ± 5 years, 22 male) with no clinical diagnosis of AD but reporting some subjective memory change and an additional 28 subjects (70 ± 9 years, 16 male) with clinically established AD...
March 1, 2017: Alzheimer's Research & Therapy
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