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Ocular pathology

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https://www.readbyqxmd.com/read/28731378/experimental-infection-of-cattle-with-a-novel-prion-derived-from-atypical-h-type-bovine-spongiform-encephalopathy
#1
Hiroyuki Okada, Kentaro Masujin, Kohtaro Miyazawa, Yoshihumi Iwamaru, Morikazu Imamura, Yuichi Matsuura, Shozo Arai, Shigeo Fukuda, Yuichi Murayama, Takashi Yokoyama
H-type bovine spongiform encephalopathy (H-BSE) is an atypical form of BSE in cattle. During passaging of H-BSE in transgenic bovinized (TgBoPrP) mice, a novel phenotype of BSE, termed BSE-SW emerged and was characterized by a short incubation time and host weight loss. To investigate the biological and biochemical properties of the BSE-SW prion, a transmission study was conducted in cattle, which were inoculated intracerebrally with brain homogenate from BSE-SW-infected TgBoPrP mice. The disease incubation period was approximately 15 months...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28727859/space-flight-associated-neuro-ocular-syndrome
#2
Andrew G Lee, Thomas H Mader, C Robert Gibson, William Tarver
New and unique physiologic and pathologic systemic and neuro-ocular responses have been documented in astronauts during and after long-duration space flight. Although the precise cause remains unknown, space flight-associated neuro-ocular syndrome (SANS) has been adopted as an appropriate descriptive term. The Space Medicine Operations Division of the US National Aeronautics and Space Administration (NASA) has documented the variable occurrence of SANS in astronauts returning from long-duration space flight on the International Space Station...
July 20, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28721008/effect-of-age-sex-and-refractive-errors-on-central-corneal-thickness-measured-by-oculus-pentacam-%C3%A2
#3
Nauman Hashmani, Sharif Hashmani, Azfar N Hanfi, Misbah Ayub, Choudhry M Saad, Hina Rajani, Marium G Muhammad, Misbahul Aziz
BACKGROUND: Central corneal thickness (CCT) can be used to assess the corneal physiological condition as well as the pathological changes associated with ocular diseases. It has an influence on the measurement of intraocular pressure and is being used as a screening tool for refractive surgery candidates. The aim of this study was to determine the median CCT among normal Pakistani population and to correlate CCT with age, sex, and refractive errors. METHODS: We conducted a retrospective analysis of 5,171 healthy eyes in 2,598 patients who came to Hashmanis Hospital, Karachi, Pakistan...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28715845/apatinib-an-inhibitor-of-vascular-endothelial-growth-factor-receptor-2-suppresses-pathologic-ocular-neovascularization-in-mice
#4
Koung Li Kim, Wonhee Suh
Purpose: Vascular endothelial growth factor (VEGF) signaling via VEGF receptor 2 (VEGFR2) plays a crucial role in pathologic ocular neovascularization. In this study, we investigated the antiangiogenic effect of apatinib, a pharmacologic inhibitor of VEGFR2 tyrosine kinase, against oxygen-induced retinopathy (OIR) and laser-induced choroidal neovascularization (CNV) in mice. Methods: Western blotting and in vitro angiogenesis assays were performed using human retinal microvascular endothelial cells (HRMECs)...
July 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28714087/clinical-and-pathological-classification-of-canine-intraocular-lymphoma
#5
Matthew R Lanza, Ayla R Musciano, Richard D Dubielzig, Amy C Durham
The objectives of this retrospective study of 100 dogs with intraocular lymphoma were to describe the histomorphologic and immunohistochemical features of canine intraocular lymphoma, determine the proportion of cases with presumed solitary ocular lymphoma (PSOL) compared to multicentric disease, and assess the clinical outcomes of these patients. Selected cases from Penn Vet Diagnostic Laboratory and Comparative Ocular Pathology Lab of Wisconsin (2004-2015) were evaluated and subtyped using the WHO classification system...
July 17, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28706770/open-globe-injury-with-an-interesting-intra-ocular-foreign-body
#6
Ekjyot Gill, Matthew Shulman, Sid Schechet, Lawson Grumbine
Introduction: Cases of penetrating ocular trauma due to osseous material are limited, so reported incidents are valuable in determining outcomes and proper treatment courses. Case description: We report a case of an open globe injury of the left eye with an intraocular foreign body occurring after a firework exploded in the hand of a 22-year-old man. The patient presented with light perception vision in the injured eye with a full-thickness limbal laceration and dense hyphema obscuring fundoscopy. CT scan revealed a hyperdense foreign body juxtaposed to the lens...
2017: GMS Ophthalmology Cases
https://www.readbyqxmd.com/read/28700420/comparison-of-2d-and-3d-video-displays-for-teaching-vitreoretinal-surgery
#7
Nisarg Chhaya, Omar Helmy, Niloofar Piri, Agustina Palacio, Shlomit Schaal
PURPOSE: To compare medical students' learning uptake and understanding of vitreoretinal surgeries by watching either 2D or 3D video recordings. METHODS: Three vitreoretinal procedures (tractional retinal detachment, exposed scleral buckle removal, and four-point scleral fixation of an intraocular lens [TSS]) were recorded simultaneously with a conventional recorder for two-dimensional viewing and a VERION 3D HD system using Sony HVO-1000MD for three-dimensional viewing...
July 11, 2017: Retina
https://www.readbyqxmd.com/read/28696042/reduced-vision-in-highly-myopic-eyes-without-ocular-pathology-the-zoc-bhvi-high-myopia-study
#8
Monica Jong, Padmaja Sankaridurg, Wayne Li, Serge Resnikoff, Kovin Naidoo, Mingguang He
BACKGROUND: The aim was to investigate the relationship of the magnitude of myopia with visual acuity in highly myopic eyes without ocular pathology. METHODS: Twelve hundred and ninety-two highly myopic eyes (up to -6.00 DS both eyes, no astigmatic cut-off) with no ocular pathology from the ZOC-BHVI high myopia study in China, had cycloplegic refraction, followed by subjective refraction and visual acuities and axial length measurement. Two logistic regression models were undertaken to test the association of age, gender, refractive error, axial length and parental myopia with reduced vision...
July 11, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28695379/expression-of-prostaglandin-e2-receptor-subtypes-in-human-pterygium-and-normal-conjunctiva-immunohistochemical-study
#9
Erdem Dinç, Özer Dursun, Banu Yılmaz, Mustafa Vatansever, A Ayça Sarı, Özlem Yıldırım, Ufuk Adıgüzel
PURPOSE: In the present study, we aimed to evaluate the expression of EP receptors in primary and recurrent human pterygium tissues. METHODS: Pterygium samples were collected from 65 patients with primary pterygium and 16 patients with recurrent pterygium. Normal conjunctival tissues were collected from nasal interpalpebral area from 17 patients without systemic and any other ocular pathology. Expression of EP receptors was evaluated by immunohistochemistry. The median value for each receptor staining score (RSS) was determined in normal conjunctival specimens...
July 10, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28694501/retinal-blood-flow-velocity-change-in-parafoveal-capillary-after-topical-tafluprost-treatment-in-eyes-with-primary-open-angle-glaucoma
#10
Yuto Iida, Tadamichi Akagi, Hideo Nakanishi, Hanako Ohashi Ikeda, Satoshi Morooka, Kenji Suda, Tomoko Hasegawa, Satoshi Yokota, Munemitsu Yoshikawa, Akihito Uji, Nagahisa Yoshimura
Although ocular circulation at the retina and optic disc is known to be associated with the pathology of glaucoma, direct measurement of blood flow velocity has been difficult to obtain. This prospective observational study enrolled 11 consecutive patients with treatment-naïve primary open-angle glaucoma (POAG) and 11 healthy subjects, and the effects of topical tafluprost treatment on ocular circulation were examined at baseline and at 1, 4, and 12 weeks after initiating treatment with topical tafluprost on POAG patients using multiple modalities, which include adaptive optics scanning laser ophthalmoscopy (AOSLO)...
July 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28688809/use-of-the-spot-vision-screener-for-patients-with-developmental-disability
#11
Amanda L Marzolf, M Millicent Peterseim, Blake D Forcina, Carrie Papa, M Edward Wilson, Edward W Cheeseman, Rupal H Trivedi
PURPOSE: To determine whether the Spot Vision Screener effectively detects amblyopia risk factors (ARF) in patients with developmental disability using the 2013 guidelines of the American Association for Pediatric Ophthalmology and Strabismus (AAPOS). METHODS: Children with developmental disability presenting for complete pediatric ophthalmologic examination were prospectively enrolled between June 2012 and March 2016. The following data were analyzed: presence of ARF according to the AAPOS guidelines, refraction, eye alignment, and other ocular pathology...
July 5, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28685998/iridociliary-cysts-masquerading-as-neoplasia-in-cats-a-morphologic-review-of-14-cases
#12
Jessica A Fragola, Richard R Dubielzig, Ellison Bentley, Leandro B C Teixeira
OBJECTIVE: To report 14 neoplasia-free feline eyes enucleated for suspected intraocular neoplasia containing only iridociliary cysts. To analyze clinical findings that may have led veterinarians to suspect neoplasia in these globes. PROCEDURES: The archives at the Comparative Ocular Pathology Laboratory of Wisconsin (COPLOW) were searched to identify neoplasia-free feline globes enucleated for suspected neoplasia. Clinical data were obtained from medical records, veterinarian surveys, and COPLOW submission forms...
July 6, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28683731/nephron-development-and-extrarenal-features-in-a-child-with-congenital-nephrotic-syndrome-caused-by-null-lamb2-mutations
#13
Jiro Kino, Hiroyasu Tsukaguchi, Takahisa Kimata, Huan Thanh Nguyen, Yorika Nakano, Noriko Miyake, Naomichi Matsumoto, Kazunari Kaneko
BACKGROUND: Congenital nephrotic syndrome (CNS) is a rare disorder caused by various structural and developmental defects of glomeruli. It occurs typically as an isolated kidney disorder but associates sometimes with other systemic, extrarenal manifestations. CASE PRESENTATIONS: An infant presented with severe CNS, which progressed rapidly to renal failure at age of 3 months and death at 27 months. The clinical phenotypes and genetic causes were studied, including the renal pathology at autopsy...
July 6, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28682947/interocular-asymmetry-in-choroidal-thickness-and-retinal-sensitivity-in-high-myopia
#14
Zeyad Alzaben, Genís Cardona, Miguel A Zapata, Ahmad Zaben
PURPOSE: To investigate the normal range of interocular asymmetry in choroidal thickness and retinal sensitivity in high myopia without ocular fundus manifestations and to determine the relationship between interocular asymmetry and refractive error. METHODS: Forty-three patients (35.07 ± 13.31 years) with high myopia and 45 healthy participants (39.9 ± 14.1 years) were administered an ocular coherence tomography and a microperimetry examination to determine choroidal thickness and retinal sensitivity at the foveal region and at 1, 2, and 3 mm, nasally, temporally, superiorly, and inferiorly...
July 6, 2017: Retina
https://www.readbyqxmd.com/read/28681278/are-we-overlooking-masked-bilateral-congenital-superior-oblique-palsy-in-children-is-it-possible-to-diagnose-before-surgery
#15
Kadriye Erkan Turan, Hande Taylan Sekeroglu, Ali Sefik Sanac
PURPOSE: To describe the characteristics of children who had subsequent contralateral superior oblique underaction (SOUA) and inferior oblique overaction (IOOA) after unilateral inferior oblique weakening surgery and to identify suggestive clinical features for masked bilateral fourth nerve palsy. METHODS: The medical records of children who underwent unilateral inferior oblique tenotomy as a single procedure for unilateral superior oblique palsy were all reviewed...
July 5, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28680052/hyperosmolarity-induced-aqp5-upregulation-promotes-inflammation-and-cell-death-via-jnk1-2-activation-in-human-corneal-epithelial-cells
#16
Yueping Ren, Huihui Lu, Peter S Reinach, Qinxiang Zheng, Jinyang Li, Qiufan Tan, Hanlei Zhu, Wei Chen
Tear film hyperosmolarity and anterior ocular inflammation are two clinical signs that may be indicative of dry eye disease (DED). This condition can cause pathological and functional changes to the anterior ocular surface tissues. A contributing factor may be dysfunctional aquaporin 5 (AQP5) water channels as they are the AQP subtype that expressed in the corneal epithelium and contribute to fluid efflux needed for corneal function. We determined if described hyperosmolarity-induced increases in proinflammatory cytokine expression and cell death are mediated through AQP5 upregulation and JNK1/2 MAPK signaling activation in both primary human corneal epithelial cells (HCECs), and in a HCEC line...
July 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28679330/altered-brain-network-centrality-in-patients-with-adult-comitant-exotropia-strabismus-a-resting-state-fmri-study
#17
Gang Tan, Zeng-Renqing Dan, Ying Zhang, Xin Huang, Yu-Lin Zhong, Lin-Hong Ye, Rong Rong, Lei Ye, Qiong Zhou, Yi Shao
Objective To investigate the underlying functional network brain-activity changes in patients with adult comitant exotropia strabismus (CES) and the relationship with clinical features using the voxel-wise degree centrality (DC) method. Methods A total of 30 patients with CES (17 men, 13 women), and 30 healthy controls (HCs; 17 men, 13 women) matched in age, sex, and education level participated in the study. DC was used to evaluate spontaneous brain activity. Receiver operating characteristic (ROC) curve analysis was conducted to distinguish CESs from HCs...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28678871/the-effect-of-infectious-dose-on-humoral-and-cellular-immune-responses-in-chlamydophila-caviae-primary-ocular-infection
#18
Ana Filipovic, Ehsan Ghasemian, Aleksandra Inic-Kanada, Ivana Lukic, Elisabeth Stein, Emilija Marinkovic, Radmila Djokic, Dejana Kosanovic, Nadine Schuerer, Hadeel Chalabi, Sandra Belij-Rammerstorfer, Marijana Stojanovic, Talin Barisani-Asenbauer
Following infection, the balance between protective immunity and immunopathology often depends on the initial infectious load. Several studies have investigated the effect of infectious dose; however, the mechanism by which infectious dose affects disease outcomes and the development of a protective immune response is not known. The aim of this study was to investigate how the infectious dose modulates the local and systemic humoral and the cellular immune responses during primary ocular chlamydial infection in the guinea pig animal model...
2017: PloS One
https://www.readbyqxmd.com/read/28677912/analysis-of-kera-in-four-families-with-cornea-plana-identifies-two-novel-mutations
#19
Lubica Dudakova, Jang Hee J Vercruyssen, Irina Balikova, Lavina Postolache, Bart P Leroy, Pavlina Skalicka, Petra Liskova
PURPOSE: To identify the molecular genetic cause in four families of various ethnic backgrounds with cornea plana. METHODS: Detailed ophthalmological examination and direct sequencing of the KERA coding region in five patients of Czech and Turkish origin and their available family members. RESULTS: Compound heterozygosity for a novel missense mutation c.209C>T; p.(Pro70Leu) and a novel splice site mutation c.887-1G>A in KERA were detected in two affected siblings of Czech origin...
July 5, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28676340/molecular-and-morphological-characterization-of-acanthamoeba-isolated-from-corneal-scrapes-and-contact-lens-wearers-in-argentina
#20
Rodolfo D Casero, Florencia Mongi, Laura Laconte, Fernando Rivero, Dario Sastre, Aníbal Teherán, Giovanny Herrera, Juan David Ramírez
In this study, we describe the frequency of Acanthamoeba keratitis (AK) in patients that assisted in the Ophthalmology Department and determine the species/genotypes of free living amoebas (FLA) isolates. FLA from Corneal scrapes (CS) and contact lens (CL) wearers were studied by morphological and molecular characterization. A database was constructed with sociodemographic, clinical findings and history of use of CL variables. During January 2000 and September 2016 patients with corneal pathology admitted to the Ophthalmology Service of the University Hospital in Córdoba city, Argentina were included in the study...
July 1, 2017: Infection, Genetics and Evolution
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